NV2t000003001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	InterPro
NV2t000005001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	InterPro
NV2t000005001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t000006001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	InterPro
NV2t000007001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	OMA
NV2t000007001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t000007001.1	molecular_function	GO:0035252	UDP-xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [PMID:30127001]	OMA
NV2t000007001.1	molecular_function	GO:0120053	ribitol beta-1,4-xylosyltransferase activity	"Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R." [PMID:27733679]	PANTHER
NV2t000008001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t000008001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t000008002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000008002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t000008002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t000008002.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t000008002.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t000008002.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000008002.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t000008003.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t000008003.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t000008004.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t000008004.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t000009001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t000009001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t000009001.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	OMA
NV2t000009001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t000009001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t000009001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t000009001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t000009001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t000009001.1	molecular_function	GO:0048027	mRNA 5'-UTR binding	"Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]	OMA
NV2t000009001.1	molecular_function	GO:0070181	small ribosomal subunit rRNA binding	"Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh]	PANTHER
NV2t000010001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000010001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000011001.1	biological_process	GO:0006520	amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]	OMA
NV2t000011001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t000011001.1	biological_process	GO:0010155	regulation of proton transport	"Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm]	OMA
NV2t000011001.1	biological_process	GO:0022898	regulation of transmembrane transporter activity	"Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]	OMA
NV2t000011001.1	biological_process	GO:0043604	amide biosynthetic process	"The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]	OMA
NV2t000011001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t000011001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	PANTHER
NV2t000011001.1	biological_process	GO:0097009	energy homeostasis	"Any process involved in the balance between food intake (energy input) and energy expenditure." [GOC:yaf, PMID:15919751]	OMA
NV2t000011001.1	biological_process	GO:1901215	obsolete negative regulation of neuron death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t000011001.1	biological_process	GO:1990845	adaptive thermogenesis	"The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363]	OMA
NV2t000011001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000011001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t000011001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t000011001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t000011002.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	PANTHER
NV2t000011002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t000011003.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	PANTHER
NV2t000012001.1	biological_process	GO:1905244	regulation of modification of synaptic structure	"Any process that modulates the frequency, rate or extent of modification of synaptic structure." [GO_REF:0000058, GOC:TermGenie, PMID:25164660]	PANTHER
NV2t000013001.1	biological_process	GO:0035194	regulatory ncRNA-mediated post-transcriptional gene silencing	"A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation." [GOC:ems, PMID:11201747, PMID:11713190, PMID:15020054, PMID:15066275, PMID:18771919, PMID:32885814, PMID:33184244]	OMA
NV2t000013001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t000013001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t000013001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t000013001.1	molecular_function	GO:0032574	5'-3' RNA helicase activity	"Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [GOC:jp]	InterPro
NV2t000013001.1	molecular_function	GO:0032574	5'-3' RNA helicase activity	"Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [GOC:jp]	OMA
NV2t000015001.1	biological_process	GO:0015803	branched-chain amino acid transport	"The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf]	OMA
NV2t000015001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t000015001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t000015001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t000015001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t000015001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	OMA
NV2t000015001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t000015001.1	molecular_function	GO:0015174	basic amino acid transmembrane transporter activity	"Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000015001.1	molecular_function	GO:0015175	neutral L-amino acid transmembrane transporter activity	"Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000015001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000015001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t000015001.1	molecular_function	GO:0015485	cholesterol binding	"Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]	OMA
NV2t000015001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t000015001.1	molecular_function	GO:0042887	amide transmembrane transporter activity	"Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]	OMA
NV2t000015001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t000015001.1	molecular_function	GO:0072349	modified amino acid transmembrane transporter activity	"Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah]	OMA
NV2t000015001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t000016001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000016001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t000017001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t000017001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	OMA
NV2t000017001.1	biological_process	GO:0043039	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	InterPro
NV2t000017001.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	OMA
NV2t000017001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000017001.1	cellular_component	GO:0009328	phenylalanine-tRNA ligase complex	"An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [PMID:20223217]	PANTHER
NV2t000017001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t000017001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t000017001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t000017001.1	molecular_function	GO:0004826	phenylalanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]	OMA
NV2t000017001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000017002.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t000017002.1	biological_process	GO:0043039	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	InterPro
NV2t000017002.1	cellular_component	GO:0009328	phenylalanine-tRNA ligase complex	"An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [PMID:20223217]	PANTHER
NV2t000018001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000018001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t000018001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t000018001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t000019001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000019001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t000020001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t000020001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t000020001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	OMA
NV2t000020001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	PANTHER
NV2t000020001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000020001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t000020001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t000020001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t000020001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t000021001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000021001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000021002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000021003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000022001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t000022001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t000022001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000022001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000022001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000023001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	InterPro
NV2t000023001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	OMA
NV2t000023001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t000023001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t000023001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t000024001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	OMA
NV2t000024001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t000024001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000024001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000024001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000024001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t000027001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000031001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t000031001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t000031001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	PANTHER
NV2t000031001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000031002.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t000031002.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t000031002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t000031002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t000031002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	PANTHER
NV2t000031002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000031003.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t000031003.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t000031003.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	PANTHER
NV2t000031003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000032001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000032001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000032002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000032002.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000035001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t000035001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t000035002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t000035002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t000036001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t000036001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t000036001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t000036001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t000036001.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	OMA
NV2t000036001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t000036001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000036001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000036001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000036001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000036001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t000036002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000036002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000039001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t000041001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	PANTHER
NV2t000042001.1	biological_process	GO:0016114	terpenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]	OMA
NV2t000042001.1	biological_process	GO:0016116	carotenoid metabolic process	"The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684]	OMA
NV2t000042001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t000042001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	InterPro
NV2t000042001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t000042001.1	molecular_function	GO:0016859	cis-trans isomerase activity	"Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732]	OMA
NV2t000047001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t000047001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000047001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t000047001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000047001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000047001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t000047001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000047001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000048001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t000048001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t000048001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t000048001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t000048001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000048001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000048001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t000048001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t000048001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t000051001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t000051001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t000051001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t000051001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	PANTHER
NV2t000051001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t000052001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000052001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000053001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	InterPro
NV2t000054001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000054001.1	biological_process	GO:0006885	regulation of pH	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t000054001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000054001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000054001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t000054001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	OMA
NV2t000054001.1	molecular_function	GO:0015385	sodium:proton antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]	OMA
NV2t000055001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t000057001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000057001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000057002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000057002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000057002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000057003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000057003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000060001.1	biological_process	GO:0006621	protein retention in ER lumen	"The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]	OMA
NV2t000060001.1	biological_process	GO:0006621	protein retention in ER lumen	"The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]	PANTHER
NV2t000060001.1	biological_process	GO:0010469	regulation of signaling receptor activity	"Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb]	OMA
NV2t000060001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t000060001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000060001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t000060001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t000063001.1	biological_process	GO:0010951	negative regulation of endopeptidase activity	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t000063001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t000063001.1	biological_process	GO:1904683	regulation of metalloendopeptidase activity	"Any process that modulates the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]	OMA
NV2t000063001.1	biological_process	GO:1904684	negative regulation of metalloendopeptidase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]	InterPro
NV2t000063001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000063001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000063001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	OMA
NV2t000063002.1	biological_process	GO:1904684	negative regulation of metalloendopeptidase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]	InterPro
NV2t000063002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000063003.1	biological_process	GO:1904684	negative regulation of metalloendopeptidase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]	InterPro
NV2t000063003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000063004.1	biological_process	GO:1904684	negative regulation of metalloendopeptidase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]	InterPro
NV2t000063004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000064001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t000064001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t000066001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000066001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000066002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000066002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000066002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000066003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000066003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000066004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000072001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000074001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t000074001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t000074001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	PANTHER
NV2t000075001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t000075001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000075001.1	biological_process	GO:0016525	negative regulation of angiogenesis	"Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]	InterPro
NV2t000075001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000075001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000075001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000077001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t000077001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000077001.1	biological_process	GO:0016525	negative regulation of angiogenesis	"Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]	InterPro
NV2t000077001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000077001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000077001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000079001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t000079001.1	biological_process	GO:0031167	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	PANTHER
NV2t000079001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t000079001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t000079001.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	InterPro
NV2t000079001.1	molecular_function	GO:0016433	rRNA (adenine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators]	OMA
NV2t000080001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000081001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t000081001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	OMA
NV2t000081001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000081001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t000081001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t000082001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t000082001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t000082001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t000082001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t000085001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000085001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000086001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t000086001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000086001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000087001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t000087001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000088001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t000088001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000088001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t000088001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t000088001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t000088001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t000088001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t000088001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t000088001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t000088001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t000088001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t000088001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t000088001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000097001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t000098001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000098001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000099001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t000099001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t000099001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t000099001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t000099001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000102001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000103001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000103001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000107001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000107002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000109001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t000109001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t000112001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t000112001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000112002.1	biological_process	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t000112002.1	biological_process	GO:0009167	purine ribonucleoside monophosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t000112002.1	biological_process	GO:0009179	purine ribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t000112002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000112002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t000112002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000112002.1	molecular_function	GO:0050145	nucleoside monophosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732]	OMA
NV2t000113001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000118001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000118001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t000118001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000118001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000118001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000118001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t000119001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	OMA
NV2t000119001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	PANTHER
NV2t000120001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t000120001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000120001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000120002.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t000120002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000120002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000122001.1	molecular_function	GO:0048018	receptor ligand activity	"The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]	PANTHER
NV2t000123001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000123001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t000123001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000124001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t000125001.1	biological_process	GO:0006405	RNA export from nucleus	"The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t000125001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t000125001.1	biological_process	GO:0071528	tRNA re-export from nucleus	"The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305]	InterPro
NV2t000125001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t000125001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000125001.1	cellular_component	GO:0016363	nuclear matrix	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]	OMA
NV2t000125001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t000125001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t000125002.1	biological_process	GO:0071528	tRNA re-export from nucleus	"The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305]	InterPro
NV2t000125003.1	biological_process	GO:0071528	tRNA re-export from nucleus	"The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305]	InterPro
NV2t000126001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t000126001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t000126001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t000126001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t000126001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t000126001.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	OMA
NV2t000126001.1	biological_process	GO:0050771	negative regulation of axonogenesis	"Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai]	OMA
NV2t000126001.1	biological_process	GO:0090317	negative regulation of intracellular protein transport	"Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t000126001.1	biological_process	GO:1905475	regulation of protein localization to membrane	"Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	OMA
NV2t000126001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000126001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t000126001.1	molecular_function	GO:0005092	GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]	OMA
NV2t000126001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000128001.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	InterPro
NV2t000128001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t000128001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t000128001.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t000128002.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	InterPro
NV2t000128002.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t000128002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t000128002.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t000128003.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	InterPro
NV2t000128003.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t000128003.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t000128003.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t000128004.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	InterPro
NV2t000128004.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t000128004.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t000128004.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t000129001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t000129001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t000129002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t000130001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t000130001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t000131001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t000131001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t000131001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000131001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000132001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t000132001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t000132001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t000132001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t000132001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t000133001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t000133001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000133001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000134001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t000134001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t000134001.1	molecular_function	GO:0070736	protein-glycine ligase activity, initiating	"Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein." [GOC:mah, PMID:19524510]	PANTHER
NV2t000137001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t000137002.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t000137002.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t000137002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t000137002.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t000137002.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t000137002.1	biological_process	GO:1903861	positive regulation of dendrite extension	"Any process that activates or increases the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855]	OMA
NV2t000137002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000137002.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t000137003.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t000138001.1	biological_process	GO:0006672	ceramide metabolic process	"The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]	OMA
NV2t000138001.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t000138001.1	molecular_function	GO:0001729	ceramide kinase activity	"Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138]	OMA
NV2t000138001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000138002.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t000138002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000139001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000139001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t000139002.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t000139002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000139002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000140001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000140001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t000140001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t000140001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t000140001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t000140001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t000141001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t000141001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	OMA
NV2t000141001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t000141001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000141001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000141001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t000141001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t000142001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t000142001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t000142002.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t000142002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t000142002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t000142003.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t000142003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t000144001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000144001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t000144001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t000145001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t000145001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	OMA
NV2t000145001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t000145001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000145001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000145001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t000145001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t000146001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000146001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t000146001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t000148001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000148001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t000148001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	OMA
NV2t000148001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t000148001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000148001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000148001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t000148001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t000150001.1	biological_process	GO:0000301	retrograde transport, vesicle recycling within Golgi	"The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363]	OMA
NV2t000150001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t000150001.1	biological_process	GO:0048219	inter-Golgi cisterna vesicle-mediated transport	"The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]	OMA
NV2t000150001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	OMA
NV2t000150001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	OMA
NV2t000150001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t000151001.1	biological_process	GO:0030322	stabilization of membrane potential	"The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t000151001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t000151001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000151001.1	molecular_function	GO:0015271	outward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]	OMA
NV2t000151001.1	molecular_function	GO:0022841	potassium ion leak channel activity	"Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000152001.1	biological_process	GO:0019184	nonribosomal peptide biosynthetic process	"The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732]	OMA
NV2t000152001.1	biological_process	GO:0044550	secondary metabolite biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]	OMA
NV2t000152001.1	biological_process	GO:0055072	obsolete iron ion homeostasis	"OBSOLETE. Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	OMA
NV2t000152001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000152001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000152001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t000152001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t000153001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000153001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t000153001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000153001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t000153001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000153001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000161001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000163001.1	biological_process	GO:0072348	sulfur compound transport	"The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t000163001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t000163001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	PANTHER
NV2t000163001.1	molecular_function	GO:0015101	organic cation transmembrane transporter activity	"Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000163001.1	molecular_function	GO:1901682	sulfur compound transmembrane transporter activity	"Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t000171001.1	biological_process	GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	"The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]	InterPro
NV2t000171001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t000171001.1	molecular_function	GO:0005459	UDP-galactose transmembrane transporter activity	"Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000173001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000173001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t000175001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t000175001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000176001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t000178001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000178001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t000178001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t000178001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t000178001.1	biological_process	GO:0038066	p38MAPK cascade	"A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:20811974, PMID:23125017, PMID:32794416]	OMA
NV2t000178001.1	biological_process	GO:0090068	positive regulation of cell cycle process	"Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t000178001.1	biological_process	GO:1901978	positive regulation of cell cycle checkpoint	"Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116]	OMA
NV2t000178001.1	biological_process	GO:2000001	regulation of DNA damage checkpoint	"Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]	OMA
NV2t000178001.1	biological_process	GO:2001022	obsolete positive regulation of response to DNA damage stimulus	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]	OMA
NV2t000178001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000178001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t000178001.1	molecular_function	GO:0004706	JUN kinase kinase kinase activity	"Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf]	OMA
NV2t000178001.1	molecular_function	GO:0004708	MAP kinase kinase activity	"Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684]	OMA
NV2t000178001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000179001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t000179001.1	cellular_component	GO:0097060	synaptic membrane	"A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]	PANTHER
NV2t000179001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000181001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000181001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000181001.1	cellular_component	GO:1902636	kinociliary basal body	"A ciliary basal body that is part of a kinocilium." [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574]	PANTHER
NV2t000183001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t000183001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t000185001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t000185001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t000189001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t000189001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000189001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t000189001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t000189001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000189002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t000189002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000189002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t000189002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t000189002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000192001.1	biological_process	GO:0007586	digestion	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]	OMA
NV2t000192001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t000192001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t000192001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t000192001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t000193001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000193001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000193001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t000193002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000193002.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t000195001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t000195001.1	cellular_component	GO:0030123	AP-3 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]	InterPro
NV2t000195002.1	biological_process	GO:0006623	protein targeting to vacuole	"The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t000195002.1	biological_process	GO:0006896	Golgi to vacuole transport	"The directed movement of substances from the Golgi to the vacuole." [GOC:ai]	OMA
NV2t000195002.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t000195002.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t000195002.1	biological_process	GO:0021700	developmental maturation	"A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t000195002.1	biological_process	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t000195002.1	biological_process	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t000195002.1	biological_process	GO:0033059	cellular pigmentation	"The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07]	OMA
NV2t000195002.1	biological_process	GO:0036466	synaptic vesicle recycling via endosome	"Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate." [GOC:aruk, GOC:bc, GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342]	OMA
NV2t000195002.1	biological_process	GO:0048490	anterograde synaptic vesicle transport	"The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg]	OMA
NV2t000195002.1	biological_process	GO:0048499	synaptic vesicle membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]	OMA
NV2t000195002.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t000195002.1	biological_process	GO:0050931	pigment cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh]	OMA
NV2t000195002.1	biological_process	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	OMA
NV2t000195002.1	biological_process	GO:0061462	protein localization to lysosome	"A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]	OMA
NV2t000195002.1	biological_process	GO:0070142	synaptic vesicle budding	"Evagination of a membrane to form a synaptic vesicle." [GOC:mah]	OMA
NV2t000195002.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	OMA
NV2t000195002.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t000195002.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t000195002.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	OMA
NV2t000195002.1	cellular_component	GO:0030123	AP-3 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]	InterPro
NV2t000195002.1	cellular_component	GO:0043195	terminal bouton	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]	OMA
NV2t000195002.1	cellular_component	GO:0098830	presynaptic endosome	"An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles." [PMID:20200227, PMID:25939282]	OMA
NV2t000195002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000195003.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t000195003.1	cellular_component	GO:0030123	AP-3 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]	InterPro
NV2t000196001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t000196001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t000196001.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t000196001.1	biological_process	GO:1901798	positive regulation of signal transduction by p53 class mediator	"Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	OMA
NV2t000196001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t000196001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t000196001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t000196001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t000196001.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	OMA
NV2t000196001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000196002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t000196002.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t000197001.1	biological_process	GO:0000350	generation of catalytic spliceosome for second transesterification step	"Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]	InterPro
NV2t000197002.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t000197002.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	InterPro
NV2t000197002.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t000197002.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t000197002.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t000197002.1	biological_process	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	OMA
NV2t000197002.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t000197002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000197002.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t000197002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t000197002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t000197002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000197002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000197002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t000197002.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t000197003.1	biological_process	GO:0000350	generation of catalytic spliceosome for second transesterification step	"Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]	InterPro
NV2t000197004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000197004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000197005.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	InterPro
NV2t000197005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000197005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000198001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t000198001.1	molecular_function	GO:0051750	delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity	"Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA." [PMID:11278886, PMID:16040662, RHEA:45240]	PANTHER
NV2t000199001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t000200001.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t000200002.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t000200002.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t000200002.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t000200002.1	molecular_function	GO:0032027	myosin light chain binding	"Binding to a light chain of a myosin complex." [GOC:mah]	OMA
NV2t000201001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t000201001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t000205001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000206001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t000206001.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t000206001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000206001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t000206002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t000206002.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t000206002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000206002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t000206003.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t000206003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t000206003.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t000206003.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t000206003.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	InterPro
NV2t000206003.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t000206003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000206003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000206003.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t000206004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t000206004.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t000206004.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	InterPro
NV2t000206004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000206004.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t000206005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t000206005.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t000206005.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	InterPro
NV2t000206005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000206005.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t000206006.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t000206006.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t000206006.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	InterPro
NV2t000206006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000206006.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t000208001.1	biological_process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]	PANTHER
NV2t000208001.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	InterPro
NV2t000208002.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t000208002.1	biological_process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]	OMA
NV2t000208002.1	biological_process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]	PANTHER
NV2t000208002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000208002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t000208002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000208002.1	cellular_component	GO:0043197	dendritic spine	"A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]	OMA
NV2t000208002.1	cellular_component	GO:0043198	dendritic shaft	"Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln]	OMA
NV2t000208002.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t000208002.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t000208002.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	InterPro
NV2t000208002.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	OMA
NV2t000208002.1	molecular_function	GO:0030291	protein serine/threonine kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah]	OMA
NV2t000208002.1	molecular_function	GO:0030551	cyclic nucleotide binding	"Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai]	OMA
NV2t000208002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t000208002.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t000208002.1	molecular_function	GO:0034236	protein kinase A catalytic subunit binding	"Binding to one or both of the catalytic subunits of protein kinase A." [GOC:mah]	OMA
NV2t000208002.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t000208003.1	biological_process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]	PANTHER
NV2t000208003.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	InterPro
NV2t000211001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000211001.1	molecular_function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t000211001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t000211002.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	InterPro
NV2t000211002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000211002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t000211003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000211003.1	molecular_function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t000211003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t000211004.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t000211004.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000211004.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000211004.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	InterPro
NV2t000211004.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	OMA
NV2t000211004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000211004.1	molecular_function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t000211004.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t000211004.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t000215001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000215001.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	OMA
NV2t000215001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t000215001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t000215001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t000215001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000215001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	InterPro
NV2t000215001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t000215001.1	molecular_function	GO:0004614	phosphoglucomutase activity	"Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2]	OMA
NV2t000215001.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	InterPro
NV2t000217001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t000217001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t000217001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000217001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000217001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000217001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000217002.1	biological_process	GO:0035196	miRNA processing	"A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604]	PANTHER
NV2t000217002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000219001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000219001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t000219001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t000219001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t000220001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t000220001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t000220001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000220002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t000220002.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t000220002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000220002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000222001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000222001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t000222001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t000222001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t000225001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t000225002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t000225002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t000225002.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t000225003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t000227001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000227001.1	biological_process	GO:0042157	lipoprotein metabolic process	"The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732]	InterPro
NV2t000227001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	PANTHER
NV2t000227001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000228001.1	biological_process	GO:0019878	lysine biosynthetic process via aminoadipic acid	"The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators]	PANTHER
NV2t000229001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000229001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000229001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t000229001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000231001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	PANTHER
NV2t000231002.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	PANTHER
NV2t000231003.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	PANTHER
NV2t000232001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t000232001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t000234001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000234001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t000234002.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000234002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t000234003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000234003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234004.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t000234004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234005.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t000234005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234006.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234007.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234008.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234009.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000234010.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000235001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t000235001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000235001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t000235001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000235001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t000236001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000237001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000237001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t000237001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000238001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t000238001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000238001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t000238001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000238001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t000239001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000239001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t000240001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t000240001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000240001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000240001.1	cellular_component	GO:1990391	DNA repair complex	"A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]	OMA
NV2t000240001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000240001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000240001.1	molecular_function	GO:0003693	P-element binding	"Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262]	OMA
NV2t000240001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000241001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	PANTHER
NV2t000241001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000241001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t000241001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t000242001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000242001.1	biological_process	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	PANTHER
NV2t000242002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000242002.1	biological_process	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	PANTHER
NV2t000242003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000242003.1	biological_process	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	PANTHER
NV2t000244001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t000244001.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t000244002.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t000244002.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t000245001.1	biological_process	GO:0018242	protein O-linked glycosylation via serine	"The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154]	OMA
NV2t000245001.1	biological_process	GO:0045747	positive regulation of Notch signaling pathway	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t000245001.1	biological_process	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	OMA
NV2t000245001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t000245001.1	molecular_function	GO:0046527	glucosyltransferase activity	"Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	PANTHER
NV2t000245001.1	molecular_function	GO:0140561	EGF-domain serine glucosyltransferase activity	"Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine." [RHEA:58116]	OMA
NV2t000245001.1	molecular_function	GO:0140562	EGF-domain serine xylosyltransferase activity	"Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine." [RHEA:62016]	OMA
NV2t000245002.1	molecular_function	GO:0046527	glucosyltransferase activity	"Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	PANTHER
NV2t000246001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000246001.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t000246002.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t000246002.1	biological_process	GO:0006882	intracellular zinc ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t000246002.1	biological_process	GO:0010312	detoxification of zinc ion	"Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators]	OMA
NV2t000246002.1	biological_process	GO:0042742	defense response to bacterium	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]	OMA
NV2t000246002.1	biological_process	GO:0046929	negative regulation of neurotransmitter secretion	"Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai]	OMA
NV2t000246002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000246002.1	biological_process	GO:0071585	detoxification of cadmium ion	"Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion." [GOC:BHF, GOC:kmv, PMID:16741752]	OMA
NV2t000246002.1	biological_process	GO:0090281	negative regulation of calcium ion import	"Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]	OMA
NV2t000246002.1	biological_process	GO:0140115	export across plasma membrane	"The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg]	OMA
NV2t000246002.1	biological_process	GO:1904063	negative regulation of cation transmembrane transport	"Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]	OMA
NV2t000246002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000246002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t000246002.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t000246002.1	cellular_component	GO:0030315	T-tubule	"Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194]	OMA
NV2t000246002.1	cellular_component	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	OMA
NV2t000246002.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t000246002.1	molecular_function	GO:0005246	calcium channel regulator activity	"Modulates the activity of a calcium channel." [GOC:mah]	OMA
NV2t000246002.1	molecular_function	GO:0005385	zinc ion transmembrane transporter activity	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t000246002.1	molecular_function	GO:0051139	metal cation:proton antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg]	OMA
NV2t000246002.1	molecular_function	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t000246003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000246003.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t000246004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000246004.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t000246005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000248001.1	biological_process	GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	"The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]	InterPro
NV2t000248001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t000248001.1	molecular_function	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	"Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000249001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t000249001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t000249001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t000249001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t000249001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t000249001.1	biological_process	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	OMA
NV2t000249001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t000249001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t000249001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t000249001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	OMA
NV2t000250001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000250002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t000250002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000250003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000250003.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000250004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000250005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000250006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000251001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t000251001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t000251001.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000251001.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000251001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t000251001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t000251001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t000251001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t000252001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t000252001.1	biological_process	GO:0007610	behavior	"The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]	OMA
NV2t000252001.1	biological_process	GO:0048667	cell morphogenesis involved in neuron differentiation	"The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]	OMA
NV2t000252001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t000252001.1	biological_process	GO:0070935	3'-UTR-mediated mRNA stabilization	"An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303]	OMA
NV2t000252001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000252001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t000252001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t000252001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t000252001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t000252001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000252001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t000252001.1	molecular_function	GO:0008143	poly(A) binding	"Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]	OMA
NV2t000252001.1	molecular_function	GO:0035925	mRNA 3'-UTR AU-rich region binding	"Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]	OMA
NV2t000252001.1	molecular_function	GO:0097158	pre-mRNA intronic pyrimidine-rich binding	"Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624, PMID:16777844]	OMA
NV2t000254001.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t000254001.1	biological_process	GO:0019509	L-methionine salvage from methylthioadenosine	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]	PANTHER
NV2t000254001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000254001.1	molecular_function	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	"Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]	InterPro
NV2t000254002.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t000254002.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t000254002.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	OMA
NV2t000254002.1	biological_process	GO:0019509	L-methionine salvage from methylthioadenosine	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]	PANTHER
NV2t000254002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000254002.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t000254002.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000254002.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t000254002.1	molecular_function	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	"Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]	InterPro
NV2t000254003.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t000254003.1	biological_process	GO:0019509	L-methionine salvage from methylthioadenosine	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]	PANTHER
NV2t000254003.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000254003.1	molecular_function	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	"Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]	InterPro
NV2t000254004.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t000254004.1	biological_process	GO:0019509	L-methionine salvage from methylthioadenosine	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]	PANTHER
NV2t000254004.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000254004.1	molecular_function	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	"Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]	InterPro
NV2t000254005.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t000254005.1	biological_process	GO:0019509	L-methionine salvage from methylthioadenosine	"The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]	PANTHER
NV2t000254005.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000254005.1	molecular_function	GO:0017061	S-methyl-5-thioadenosine phosphorylase activity	"Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]	InterPro
NV2t000255001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t000255001.1	biological_process	GO:0006029	proteoglycan metabolic process	"The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]	OMA
NV2t000255001.1	biological_process	GO:0006516	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t000255001.1	biological_process	GO:0030200	heparan sulfate proteoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t000255001.1	biological_process	GO:0044273	sulfur compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]	OMA
NV2t000255001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t000255001.1	molecular_function	GO:0005539	glycosaminoglycan binding	"Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t000255001.1	molecular_function	GO:0008449	N-acetylglucosamine-6-sulfatase activity	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]	OMA
NV2t000255002.1	biological_process	GO:0030200	heparan sulfate proteoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t000255003.1	biological_process	GO:0030200	heparan sulfate proteoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t000256001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t000256001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000256001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t000256001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t000256001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000257001.1	biological_process	GO:0000266	mitochondrial fission	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]	OMA
NV2t000257001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000257001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t000257001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000257001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000257001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t000257001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000257001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t000257001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t000257002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000257002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000258001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	InterPro
NV2t000258001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	OMA
NV2t000259001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t000259001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t000259001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000259002.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t000259002.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t000259002.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	OMA
NV2t000259002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t000259002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000259003.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t000259003.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t000259003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000259004.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t000259004.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t000259004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000259005.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t000259005.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t000259005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000260001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t000260001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t000261001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t000261001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000261001.1	biological_process	GO:0032922	circadian regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]	OMA
NV2t000261001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t000261001.1	biological_process	GO:0051090	regulation of DNA-binding transcription factor activity	"Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t000261001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000261001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t000261001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t000261001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000261001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t000261001.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	OMA
NV2t000261001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000261001.1	molecular_function	GO:0034647	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	"Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17550896, PMID:22473470]	OMA
NV2t000261001.1	molecular_function	GO:0034647	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	"Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17550896, PMID:22473470]	PANTHER
NV2t000261001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t000262001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t000262001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000262001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t000262001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t000264001.1	cellular_component	GO:0061617	MICOS complex	"Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]	PANTHER
NV2t000265001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000265002.1	biological_process	GO:0000712	resolution of meiotic recombination intermediates	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]	OMA
NV2t000265002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000265002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000265002.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t000265002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000265002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000265003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000266001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t000268001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t000270001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000270001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000270001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000270001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000270002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000270002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000270003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000270004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000270005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000272001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	OMA
NV2t000272001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	PANTHER
NV2t000273001.1	biological_process	GO:0071763	nuclear membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah]	PANTHER
NV2t000274001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	PANTHER
NV2t000274001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000276001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t000276001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000279001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t000281001.1	biological_process	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	InterPro
NV2t000281001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t000281002.1	biological_process	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	InterPro
NV2t000281002.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t000281003.1	biological_process	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	InterPro
NV2t000281003.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t000281004.1	biological_process	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	InterPro
NV2t000281004.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t000281005.1	biological_process	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	InterPro
NV2t000281005.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t000281006.1	biological_process	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	InterPro
NV2t000281006.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t000281007.1	biological_process	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	InterPro
NV2t000281007.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t000281008.1	biological_process	GO:0006006	glucose metabolic process	"The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732]	InterPro
NV2t000281008.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t000284001.1	biological_process	GO:0033353	S-adenosylmethionine cycle	"A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]	PANTHER
NV2t000284002.1	biological_process	GO:0033353	S-adenosylmethionine cycle	"A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]	PANTHER
NV2t000284003.1	biological_process	GO:0033353	S-adenosylmethionine cycle	"A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]	PANTHER
NV2t000284004.1	biological_process	GO:0033353	S-adenosylmethionine cycle	"A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]	PANTHER
NV2t000287001.1	biological_process	GO:0033353	S-adenosylmethionine cycle	"A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]	PANTHER
NV2t000289001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000289001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000289001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t000290001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t000290001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000290002.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t000290002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000290003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t000290003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000290004.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t000290004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000290005.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t000290005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000290006.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t000290006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000291001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	PANTHER
NV2t000292001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	PANTHER
NV2t000292001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000293001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t000293001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000295001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000295001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t000295001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	PANTHER
NV2t000295001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t000295001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000295001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000295001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000296001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	InterPro
NV2t000296001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	InterPro
NV2t000296001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000296001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t000296002.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	InterPro
NV2t000296002.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t000296002.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t000296002.1	biological_process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t000296002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	InterPro
NV2t000296002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t000296002.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t000296002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000296002.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t000296002.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t000296002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000296002.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t000296002.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t000296002.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	OMA
NV2t000296002.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t000296002.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t000298001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000301001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000302001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	OMA
NV2t000302001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t000302001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000302001.1	molecular_function	GO:0001640	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	"Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph]	OMA
NV2t000302002.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t000302003.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t000307001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000307001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000307001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000309001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000309001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000309001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000312001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000312001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000312001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000315001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000315001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t000315002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000317001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000317001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000317001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000320001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000320001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t000322001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t000324001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t000324001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t000324001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000324001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t000324001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000325001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t000326001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000327001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000328001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000329001.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t000329001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000329001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000329001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000331001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000331001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000331001.1	molecular_function	GO:0015095	magnesium ion transmembrane transporter activity	"Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t000332001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t000332001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t000332001.1	molecular_function	GO:0004806	triglyceride lipase activity	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]	OMA
NV2t000332001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000332001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000332001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t000333001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	PANTHER
NV2t000335001.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t000336001.1	biological_process	GO:0006549	isoleucine metabolic process	"The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	OMA
NV2t000336001.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t000336001.1	biological_process	GO:0009068	aspartate family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t000336001.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t000336001.1	biological_process	GO:1901607	alpha-amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t000336001.1	molecular_function	GO:0016840	carbon-nitrogen lyase activity	"Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]	OMA
NV2t000337001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t000337001.1	biological_process	GO:0030206	chondroitin sulfate biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]	OMA
NV2t000337001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t000337001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t000337001.1	molecular_function	GO:0005461	UDP-glucuronic acid transmembrane transporter activity	"Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000337001.1	molecular_function	GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity	"Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000337001.1	molecular_function	GO:0005463	UDP-N-acetylgalactosamine transmembrane transporter activity	"Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000337001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t000337001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t000343001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t000343001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t000343001.1	biological_process	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	OMA
NV2t000343001.1	biological_process	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	OMA
NV2t000343001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t000343001.1	biological_process	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	OMA
NV2t000343001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000343001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t000343001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t000343001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t000343002.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t000343002.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t000346001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t000346001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000347001.1	biological_process	GO:0001654	eye development	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]	OMA
NV2t000347001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t000347001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t000347001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	OMA
NV2t000347001.1	biological_process	GO:0031324	negative regulation of cellular metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t000347001.1	biological_process	GO:0051445	regulation of meiotic cell cycle	"Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t000347001.1	biological_process	GO:0051783	regulation of nuclear division	"Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]	OMA
NV2t000347001.1	biological_process	GO:1904668	positive regulation of ubiquitin protein ligase activity	"Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882]	OMA
NV2t000347001.1	biological_process	GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	"Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876]	OMA
NV2t000347001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t000347001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000347001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000347001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t000347001.1	molecular_function	GO:0010997	anaphase-promoting complex binding	"Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t000347001.1	molecular_function	GO:1990757	ubiquitin ligase activator activity	"Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242]	PANTHER
NV2t000348001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t000348001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	InterPro
NV2t000350001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t000350001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000350001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t000351001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t000351001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000351001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t000351001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000351001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t000351001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t000351002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000351002.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t000353001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t000353001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t000353001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t000353001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	OMA
NV2t000353001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t000353001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	OMA
NV2t000353001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t000353001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t000353001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t000356001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t000356001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	InterPro
NV2t000356001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	OMA
NV2t000356001.1	biological_process	GO:0033962	P-body assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]	OMA
NV2t000356001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t000356001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t000356001.1	cellular_component	GO:0097526	spliceosomal tri-snRNP complex	"A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]	PANTHER
NV2t000356001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t000356001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000356001.1	molecular_function	GO:0017070	U6 snRNA binding	"Binding to a U6 small nuclear RNA (U6 snRNA)." [GOC:mah]	OMA
NV2t000357001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t000357001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t000357001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	OMA
NV2t000357001.1	biological_process	GO:0043244	regulation of protein-containing complex disassembly	"Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]	OMA
NV2t000357001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t000357001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t000357001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t000357001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t000357001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t000357001.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t000357001.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	PANTHER
NV2t000357001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t000357001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t000357001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t000360001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000361001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t000361001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000361002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t000361002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000361003.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t000361003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000361004.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t000361004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000361005.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t000361005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000361006.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t000361006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000362001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t000362001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t000362001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000362001.1	cellular_component	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	OMA
NV2t000362001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000362001.1	molecular_function	GO:0004535	poly(A)-specific ribonuclease activity	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]	OMA
NV2t000362001.1	molecular_function	GO:0017069	snRNA binding	"Binding to a small nuclear RNA (snRNA)." [GOC:mah]	OMA
NV2t000362001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000362001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t000362002.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t000362002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000362002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000363002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t000365001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t000365001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000365001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000368001.1	biological_process	GO:0010961	intracellular magnesium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of magnesium ions within a cell." [GOC:dph, GOC:tb]	OMA
NV2t000368001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t000368001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t000368001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t000368001.1	molecular_function	GO:0008324	monoatomic cation transmembrane transporter activity	"Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000368001.1	molecular_function	GO:0015081	sodium ion transmembrane transporter activity	"Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF, RHEA:34963]	OMA
NV2t000368001.1	molecular_function	GO:0015095	magnesium ion transmembrane transporter activity	"Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t000368001.1	molecular_function	GO:0140828	metal cation:monoatomic cation antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out)." [GOC:pg]	OMA
NV2t000368002.1	molecular_function	GO:0008324	monoatomic cation transmembrane transporter activity	"Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000369001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t000369001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t000369001.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t000369001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000369001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000369001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000369001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t000369001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	InterPro
NV2t000369001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t000369001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t000371001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t000371001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000371001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t000373001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000373001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t000373001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t000373001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t000373001.1	biological_process	GO:0043968	obsolete histone H2A acetylation	"OBSOLETE. The modification of histone H2A by the addition of an acetyl group." [GOC:jl]	InterPro
NV2t000373001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000373001.1	cellular_component	GO:0000118	histone deacetylase complex	"A protein complex that possesses histone deacetylase activity." [GOC:mah]	OMA
NV2t000373001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t000373001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t000373001.1	cellular_component	GO:0097346	INO80-type complex	"A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820]	OMA
NV2t000373001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t000374001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t000375001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t000376002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t000376002.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t000376002.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	OMA
NV2t000376002.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	PANTHER
NV2t000376004.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	PANTHER
NV2t000377001.1	biological_process	GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	"Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]	PANTHER
NV2t000377001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	InterPro
NV2t000377001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000377002.1	biological_process	GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	"Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]	PANTHER
NV2t000377002.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	InterPro
NV2t000377002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000377003.1	biological_process	GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	"Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]	PANTHER
NV2t000377003.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	InterPro
NV2t000377003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000377003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000378001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t000378001.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	OMA
NV2t000378001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t000378001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t000378001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t000378001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t000378001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000378001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000378002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000379001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t000379001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t000379001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t000379001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t000379001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t000379001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t000379001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t000379001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t000379001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t000380001.1	biological_process	GO:0006448	regulation of translational elongation	"Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]	OMA
NV2t000380001.1	biological_process	GO:0017183	protein histidyl modification to diphthamide	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380]	InterPro
NV2t000380001.1	biological_process	GO:0018202	peptidyl-histidine modification	"The modification of peptidyl-histidine." [GOC:ma]	OMA
NV2t000380001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t000380001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t000380001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t000382001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000382001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t000384001.1	biological_process	GO:0006882	intracellular zinc ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t000384001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000384001.1	biological_process	GO:0140820	cytosol to Golgi apparatus transport	"The directed movement of substances from the cytosol into the Golgi apparatus of a cell." [PMID:28373556]	OMA
NV2t000384001.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t000384001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t000384001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t000384001.1	molecular_function	GO:0005385	zinc ion transmembrane transporter activity	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t000384002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000384002.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t000384003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000384003.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t000384005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000384005.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t000384006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000384006.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t000385001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	OMA
NV2t000385001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000385001.1	molecular_function	GO:0008482	sulfite oxidase activity	"Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate." [EC:1.8.3.1, RHEA:24600]	OMA
NV2t000385001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000385001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t000385001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t000385001.1	molecular_function	GO:0030151	molybdenum ion binding	"Binding to a molybdenum ion (Mo)." [GOC:ai]	InterPro
NV2t000385001.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	InterPro
NV2t000385001.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t000385001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t000385002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000385002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t000385002.1	molecular_function	GO:0030151	molybdenum ion binding	"Binding to a molybdenum ion (Mo)." [GOC:ai]	InterPro
NV2t000385002.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	InterPro
NV2t000385002.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t000385003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000385003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t000385003.1	molecular_function	GO:0030151	molybdenum ion binding	"Binding to a molybdenum ion (Mo)." [GOC:ai]	InterPro
NV2t000385003.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	InterPro
NV2t000385003.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t000388001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t000388001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t000388001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t000388002.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t000388002.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t000388002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t000392004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000393001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000393001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000393002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000395001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000396001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000396001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000396001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000396001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t000399001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000399001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t000399001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t000403001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t000403001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t000403001.1	molecular_function	GO:0016274	protein-arginine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [GOC:mah, PMID:12351636, PMID:31284549]	OMA
NV2t000405001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t000405001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000405001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t000405001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t000405001.1	cellular_component	GO:0005854	nascent polypeptide-associated complex	"A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149]	OMA
NV2t000405001.1	cellular_component	GO:0042788	obsolete polysomal ribosome	"OBSOLETE. A ribosome bound to mRNA that forms part of a polysome." [GOC:jl]	PANTHER
NV2t000405001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000406001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000406001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t000406001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t000407001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t000407003.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t000407004.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t000408001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t000408001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t000408001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t000408001.1	cellular_component	GO:0030121	AP-1 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]	OMA
NV2t000408001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t000408001.1	molecular_function	GO:0035615	clathrin adaptor activity	"Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]	OMA
NV2t000408001.1	molecular_function	GO:0035615	clathrin adaptor activity	"Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]	PANTHER
NV2t000409001.1	biological_process	GO:0006301	postreplication repair	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh]	OMA
NV2t000409001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t000409001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t000409001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t000409001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t000411001.1	biological_process	GO:0046185	aldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t000411001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000411001.1	molecular_function	GO:0008106	alcohol dehydrogenase (NADP+) activity	"Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2]	OMA
NV2t000411001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000412001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	PANTHER
NV2t000412002.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	PANTHER
NV2t000412003.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	OMA
NV2t000412003.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	PANTHER
NV2t000412003.1	biological_process	GO:0046601	positive regulation of centriole replication	"Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai]	OMA
NV2t000412003.1	biological_process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t000412003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000412003.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t000412003.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t000412003.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t000413001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t000413001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t000413001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t000413001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000413001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t000413001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t000414001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t000414001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t000414001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t000414002.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t000415001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000415001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000415001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000415001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t000415002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000416001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t000416001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t000416001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t000416002.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t000419001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000420001.1	biological_process	GO:0010508	positive regulation of autophagy	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t000420001.1	biological_process	GO:0033673	negative regulation of kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t000420001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t000420001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t000420001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t000420001.1	cellular_component	GO:0035859	Seh1-associated complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112]	OMA
NV2t000420001.1	cellular_component	GO:1990130	GATOR1 complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]	PANTHER
NV2t000420001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t000420001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t000422001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t000422001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t000422001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t000423001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t000423001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000423001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000423001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t000423001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t000423001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t000423001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t000423001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t000424001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000424001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t000424002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000424002.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t000424003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000424003.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t000424004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000424004.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t000424005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000424005.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t000425001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000425001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000425001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t000426001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t000426001.1	molecular_function	GO:0008430	selenium binding	"Binding to a selenium (Se) ion." [GOC:ai]	PANTHER
NV2t000429001.1	cellular_component	GO:0030686	90S preribosome	"A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]	PANTHER
NV2t000430001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t000430001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t000430001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t000430001.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	InterPro
NV2t000431001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t000431001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t000431001.1	biological_process	GO:0030111	regulation of Wnt signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t000431001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	OMA
NV2t000431001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t000431001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000431001.1	molecular_function	GO:0008195	phosphatidate phosphatase activity	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [GOC:pr, PMID:25814022, RHEA:27429]	OMA
NV2t000431001.1	molecular_function	GO:0042577	lipid phosphatase activity	"Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]	OMA
NV2t000432001.1	biological_process	GO:0045048	protein insertion into ER membrane	"The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]	InterPro
NV2t000432001.1	biological_process	GO:0045048	protein insertion into ER membrane	"The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]	OMA
NV2t000432001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t000435001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000435002.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000435003.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000437001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t000437001.1	biological_process	GO:0048477	oogenesis	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]	OMA
NV2t000437001.1	biological_process	GO:0048477	oogenesis	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]	PANTHER
NV2t000437001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t000437001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t000437001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000439001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000439002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000441001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t000441001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000445001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000445001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t000447001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t000447001.1	biological_process	GO:0035212	cell competition in a multicellular organism	"Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]	OMA
NV2t000447001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000447001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t000447001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t000447001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000447001.1	molecular_function	GO:0016922	nuclear receptor binding	"Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974]	OMA
NV2t000447001.1	molecular_function	GO:0035184	obsolete histone threonine kinase activity	"OBSOLETE. Catalysis of the transfer of a phosphate group to a threonine residue of a histone." [GOC:bf]	OMA
NV2t000449001.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	OMA
NV2t000449001.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	PANTHER
NV2t000453001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000453001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t000453001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000453001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t000454001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t000454001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000454001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t000454001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t000454001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000457001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000459001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000460001.1	biological_process	GO:0017004	cytochrome complex assembly	"The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah]	OMA
NV2t000460001.1	biological_process	GO:0018063	cytochrome c-heme linkage	"The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135]	PANTHER
NV2t000460001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t000460001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t000460001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000460001.1	molecular_function	GO:0016846	carbon-sulfur lyase activity	"Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]	OMA
NV2t000460001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t000464001.1	biological_process	GO:0032224	positive regulation of synaptic transmission, cholinergic	"Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]	OMA
NV2t000464001.1	biological_process	GO:0032228	regulation of synaptic transmission, GABAergic	"Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]	OMA
NV2t000464001.1	biological_process	GO:0032230	positive regulation of synaptic transmission, GABAergic	"Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]	PANTHER
NV2t000464001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000464001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000464001.1	molecular_function	GO:0005261	monoatomic cation channel activity	"Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t000465001.1	cellular_component	GO:1990316	Atg1/ULK1 kinase complex	"A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]	PANTHER
NV2t000468001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t000468001.1	biological_process	GO:0070973	protein localization to endoplasmic reticulum exit site	"A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah]	PANTHER
NV2t000468001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000469001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000470001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t000471001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t000471002.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t000472001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000476001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000481001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t000481001.1	biological_process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]	OMA
NV2t000481001.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	OMA
NV2t000481001.1	biological_process	GO:0018205	peptidyl-lysine modification	"The modification of peptidyl-lysine." [GOC:go_curators]	OMA
NV2t000481001.1	biological_process	GO:0034247	snoRNA splicing	"The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." [GOC:mah]	PANTHER
NV2t000481001.1	biological_process	GO:0043144	sno(s)RNA processing	"Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea)." [GOC:go_curators, GOC:krc, PMID:12773397]	OMA
NV2t000481001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t000481001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t000481001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000481001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t000481001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t000482001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t000482001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t000483001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t000483001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t000483001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000483001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000483001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000486001.1	biological_process	GO:2000301	negative regulation of synaptic vesicle exocytosis	"Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]	PANTHER
NV2t000486001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000487001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000488001.1	biological_process	GO:0071216	cellular response to biotic stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]	PANTHER
NV2t000488002.1	biological_process	GO:0071216	cellular response to biotic stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]	PANTHER
NV2t000488003.1	biological_process	GO:0071216	cellular response to biotic stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]	PANTHER
NV2t000490001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t000490001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000490002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t000490002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t000490002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000492001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000492002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000492002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t000492003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000495001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t000495001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000495001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000495001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t000497001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t000497001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000497001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000497001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t000500001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t000500001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000500001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000500001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t000502001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t000502001.1	biological_process	GO:0008045	motor neuron axon guidance	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]	PANTHER
NV2t000502001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000503001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000504001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000506001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000506001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000507001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t000507001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t000507001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000507001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000507001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	OMA
NV2t000507001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t000507001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t000509001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t000509001.1	biological_process	GO:0006892	post-Golgi vesicle-mediated transport	"The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]	OMA
NV2t000509001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t000509001.1	biological_process	GO:0016050	vesicle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]	OMA
NV2t000509001.1	biological_process	GO:0016050	vesicle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]	PANTHER
NV2t000509001.1	biological_process	GO:0016482	cytosolic transport	"The directed movement of substances or organelles within the cytosol." [GOC:ai]	OMA
NV2t000509001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t000509001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000509001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000509001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000509001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	OMA
NV2t000510001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t000510001.1	biological_process	GO:0007020	microtubule nucleation	"The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]	OMA
NV2t000510001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t000510001.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	OMA
NV2t000510001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	OMA
NV2t000510001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t000510001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t000510001.1	cellular_component	GO:0000931	gamma-tubulin ring complex	"A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075, PMID:17021256]	OMA
NV2t000510001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t000510001.1	cellular_component	GO:0008275	gamma-tubulin small complex	"A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075]	OMA
NV2t000510001.1	cellular_component	GO:0032153	cell division site	"The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]	OMA
NV2t000510001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	InterPro
NV2t000510001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	OMA
NV2t000510001.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	OMA
NV2t000511001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000511001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000511001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000512001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000512001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000512001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000512001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000513001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000513001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000513001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000513002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000513002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000515001.1	cellular_component	GO:0097344	obsolete Rix1 complex	"OBSOLETE. A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes." [GOC:vw, PMID:14759368, PMID:15260980, PMID:21385875]	PANTHER
NV2t000515001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000516001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t000516001.1	biological_process	GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair	"Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477]	PANTHER
NV2t000516001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t000519001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000519001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000519001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000519001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t000519003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000519003.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000521001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000521001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000521001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000521001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t000521002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000521002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000521003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000521003.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000521004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000521004.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000522001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t000522001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t000522001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t000523001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t000523001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t000524001.1	biological_process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw]	PANTHER
NV2t000526001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t000526001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t000526001.1	molecular_function	GO:0004806	triglyceride lipase activity	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]	OMA
NV2t000526001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000526001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000526001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t000527001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000528001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t000528001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t000530001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t000530001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000530001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t000532001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000532001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	InterPro
NV2t000532001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000532002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000532002.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	InterPro
NV2t000532002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000532003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000532003.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	InterPro
NV2t000532003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000532004.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000532004.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	InterPro
NV2t000532004.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t000532004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000532005.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000532005.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	InterPro
NV2t000532005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000535001.1	biological_process	GO:0006497	protein lipidation	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]	OMA
NV2t000535001.1	biological_process	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	OMA
NV2t000535001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	OMA
NV2t000535001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t000535001.1	molecular_function	GO:0019787	ubiquitin-like protein transferase activity	"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]	InterPro
NV2t000535001.1	molecular_function	GO:0019787	ubiquitin-like protein transferase activity	"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]	OMA
NV2t000538001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t000538001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t000538001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t000539001.1	biological_process	GO:0010888	negative regulation of lipid storage	"Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t000539001.1	biological_process	GO:0019218	regulation of steroid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]	OMA
NV2t000539001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t000539001.1	biological_process	GO:0042632	cholesterol homeostasis	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]	OMA
NV2t000539001.1	biological_process	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t000539001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000540001.1	molecular_function	GO:0032454	histone H3K9 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein." [PMID:16362057]	PANTHER
NV2t000544001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t000544001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t000544001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t000544001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t000544001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t000544002.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t000545001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000545002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000547001.1	molecular_function	GO:0032454	histone H3K9 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein." [PMID:16362057]	PANTHER
NV2t000547002.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t000547002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000547002.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t000547002.1	molecular_function	GO:0032454	histone H3K9 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein." [PMID:16362057]	OMA
NV2t000547002.1	molecular_function	GO:0032454	histone H3K9 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein." [PMID:16362057]	PANTHER
NV2t000547003.1	molecular_function	GO:0032454	histone H3K9 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein." [PMID:16362057]	PANTHER
NV2t000547004.1	molecular_function	GO:0032454	histone H3K9 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein." [PMID:16362057]	PANTHER
NV2t000552001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t000552001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000552001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000552001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t000553001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000553001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t000553001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000553001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t000553001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000553002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000553002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000553002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000554001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000554001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000554001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000555001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t000555001.1	biological_process	GO:0006268	DNA unwinding involved in DNA replication	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]	OMA
NV2t000555001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t000555001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t000555001.1	biological_process	GO:0007423	sensory organ development	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]	OMA
NV2t000555001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t000555001.1	biological_process	GO:0032780	negative regulation of ATP-dependent activity	"Any process that stops or reduces the rate of an ATP-dependent activity." [GOC:mah]	OMA
NV2t000555001.1	biological_process	GO:0043086	negative regulation of catalytic activity	"Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t000555001.1	biological_process	GO:0065004	protein-DNA complex assembly	"The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl]	OMA
NV2t000555001.1	biological_process	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	OMA
NV2t000555001.1	biological_process	GO:1902975	mitotic DNA replication initiation	"Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]	PANTHER
NV2t000555001.1	biological_process	GO:1905775	negative regulation of DNA helicase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539]	InterPro
NV2t000555001.1	biological_process	GO:2001251	negative regulation of chromosome organization	"Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t000555001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t000555001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000555001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	OMA
NV2t000555001.1	cellular_component	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	OMA
NV2t000555001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t000555001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000555001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000555001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t000555001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	OMA
NV2t000555001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t000556001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t000556001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	PANTHER
NV2t000556001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	OMA
NV2t000556001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t000556002.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	PANTHER
NV2t000557001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000557001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000557001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000557001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t000557001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t000558001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000558001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000558001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t000561001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t000561001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t000561001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	PANTHER
NV2t000564001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000564001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t000564001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t000564001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t000564002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t000564002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t000565001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000566001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000566001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t000566001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t000570001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t000570001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000570001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000570001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000570001.1	molecular_function	GO:0015276	ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000571001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t000571001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000571001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t000571001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t000571001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000571001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t000571001.1	molecular_function	GO:0008331	high voltage-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]	OMA
NV2t000571002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000571002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t000571002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000571003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000571003.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t000571003.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000571004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000571004.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t000571004.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t000572001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000572001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t000572001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	OMA
NV2t000572001.1	biological_process	GO:0006605	protein targeting	"The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	OMA
NV2t000572001.1	biological_process	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t000572001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t000572001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t000572001.1	biological_process	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	"An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component." [GOC:al, GOC:bf, PMID:16079177]	OMA
NV2t000572001.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t000572001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000572001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000572001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000572001.1	molecular_function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655]	OMA
NV2t000572001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000572001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000572002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000572002.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t000572002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000574001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t000574001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t000574001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000574001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000574002.1	biological_process	GO:0007276	gamete generation	"The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]	OMA
NV2t000574002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t000574002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000574002.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t000574002.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t000574002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t000574002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t000574002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t000574002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000574002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000574002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000574002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000576001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000576001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000576001.1	biological_process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	"Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]	PANTHER
NV2t000576001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000578001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000578001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t000578001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000578001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000579001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000579001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t000579001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000581001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000581002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000581003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000581003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t000581003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t000581003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000581003.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t000584001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000584001.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	PANTHER
NV2t000585001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000585001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t000585001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000588001.1	biological_process	GO:1901987	regulation of cell cycle phase transition	"Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]	PANTHER
NV2t000592001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000593001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000594001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000594001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t000594001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000595001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000595001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t000595001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t000595001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000595001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t000595002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000595002.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	PANTHER
NV2t000598001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000598001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t000598001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t000598001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t000599001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000599002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000600001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000600001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000601001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000601001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000605001.1	biological_process	GO:0006552	L-leucine catabolic process	"The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]	OMA
NV2t000605001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000605001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t000605001.1	cellular_component	GO:1905202	methylcrotonoyl-CoA carboxylase complex	"A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity." [GO_REF:0000088, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22158123]	PANTHER
NV2t000605001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	InterPro
NV2t000605001.1	molecular_function	GO:0016885	ligase activity, forming carbon-carbon bonds	"Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-, GOC:jl, GOC:mah]	OMA
NV2t000607001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t000607001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000607001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000607001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t000607002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000609001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000609001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000610001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t000610001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t000610001.1	biological_process	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t000610001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t000610001.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t000610001.1	biological_process	GO:1904294	positive regulation of ERAD pathway	"Any process that activates or increases the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]	PANTHER
NV2t000610001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000610002.1	biological_process	GO:1904294	positive regulation of ERAD pathway	"Any process that activates or increases the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]	PANTHER
NV2t000610003.1	biological_process	GO:1904294	positive regulation of ERAD pathway	"Any process that activates or increases the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]	PANTHER
NV2t000612001.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t000612001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000612001.1	molecular_function	GO:0005337	nucleoside transmembrane transporter activity	"Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]	OMA
NV2t000614001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t000614001.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t000614001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t000614001.1	biological_process	GO:0046950	cellular ketone body metabolic process	"The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732]	OMA
NV2t000614001.1	biological_process	GO:0046950	cellular ketone body metabolic process	"The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732]	PANTHER
NV2t000614001.1	biological_process	GO:0046952	ketone body catabolic process	"The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732]	InterPro
NV2t000614001.1	biological_process	GO:1902224	ketone body metabolic process	"The chemical reactions and pathways involving ketone body." [GOC:pr, GOC:TermGenie]	OMA
NV2t000614001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000614001.1	molecular_function	GO:0008260	succinyl-CoA:3-oxo-acid CoA-transferase activity	"Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [GOC:vw, PMID:10964512, PMID:8844009, RHEA:24564]	OMA
NV2t000614001.1	molecular_function	GO:0008410	CoA-transferase activity	"Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t000618001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t000620001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000620001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000620001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000622001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000622001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000622001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	PANTHER
NV2t000622001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000622001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000622002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000622002.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	PANTHER
NV2t000622002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000622003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000622003.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	PANTHER
NV2t000622003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000623002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000623002.1	cellular_component	GO:0030176	obsolete integral component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t000623002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000623003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000623003.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t000623003.1	cellular_component	GO:0030176	obsolete integral component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t000623003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t000623003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000628001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000632001.1	biological_process	GO:0046487	glyoxylate metabolic process	"The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]	OMA
NV2t000632001.1	molecular_function	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]	OMA
NV2t000633001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	OMA
NV2t000633001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	OMA
NV2t000633001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	PANTHER
NV2t000633001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000633001.1	molecular_function	GO:0032977	membrane insertase activity	"Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]	OMA
NV2t000634001.1	cellular_component	GO:0070762	nuclear pore transmembrane ring	"A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t000636001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t000636001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t000636001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t000636001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t000636001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t000636001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t000636001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t000637001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t000637001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t000637001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t000637001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t000637001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000637001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t000637001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t000637001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t000638001.1	biological_process	GO:0098968	neurotransmitter receptor transport postsynaptic membrane to endosome	"Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome." [GOC:dos]	PANTHER
NV2t000638001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000638002.1	biological_process	GO:0098968	neurotransmitter receptor transport postsynaptic membrane to endosome	"Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome." [GOC:dos]	PANTHER
NV2t000638002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000642001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000642001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000642003.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	PANTHER
NV2t000642003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000643001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000643001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000644001.1	biological_process	GO:0085020	protein K6-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]	PANTHER
NV2t000644001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000645001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000645001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t000645002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000646001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t000646001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t000646001.1	biological_process	GO:0042278	purine nucleoside metabolic process	"The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]	OMA
NV2t000646001.1	biological_process	GO:0140291	peptidyl-glutamate ADP-deribosylation	"The removal of ADP-ribose from ADP-ribosylglutamate." [PMID:23481255]	PANTHER
NV2t000646001.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	OMA
NV2t000646001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	OMA
NV2t000646001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	OMA
NV2t000646001.1	molecular_function	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	OMA
NV2t000646001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t000646001.1	molecular_function	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	OMA
NV2t000646001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t000649001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000649001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000649003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000649004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649006.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000649006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649007.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649008.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649009.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000649010.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000650001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t000650001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t000650001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t000650001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000650001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000651001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000651001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000653001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000653001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000653001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000653001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t000655001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t000655001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t000655001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t000655001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	PANTHER
NV2t000655001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t000655001.1	biological_process	GO:2000786	positive regulation of autophagosome assembly	"Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t000655001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t000655001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t000655001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t000655001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t000656001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000656001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t000656001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000656001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t000657001.1	biological_process	GO:0015804	neutral amino acid transport	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t000657001.1	biological_process	GO:0015811	L-cystine transport	"The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t000657001.1	biological_process	GO:0072348	sulfur compound transport	"The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t000657001.1	cellular_component	GO:0005774	vacuolar membrane	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]	OMA
NV2t000657001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t000657001.1	molecular_function	GO:0072349	modified amino acid transmembrane transporter activity	"Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah]	OMA
NV2t000657001.1	molecular_function	GO:1901682	sulfur compound transmembrane transporter activity	"Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t000658001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	PANTHER
NV2t000658001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t000658001.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	InterPro
NV2t000658001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t000658001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t000658001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t000658002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	PANTHER
NV2t000658002.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	InterPro
NV2t000659001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000659001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000659002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t000659002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000659002.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t000659002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000660001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000662001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000664001.1	biological_process	GO:0000492	box C/D snoRNP assembly	"The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]	InterPro
NV2t000664001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t000664001.1	molecular_function	GO:0062064	box C/D methylation guide snoRNP complex binding	"Binding to a box C/D methylation guide snoRNP complex." [PMID:10679015]	PANTHER
NV2t000664002.1	biological_process	GO:0000492	box C/D snoRNP assembly	"The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]	InterPro
NV2t000664002.1	molecular_function	GO:0062064	box C/D methylation guide snoRNP complex binding	"Binding to a box C/D methylation guide snoRNP complex." [PMID:10679015]	PANTHER
NV2t000665001.1	biological_process	GO:0022409	positive regulation of cell-cell adhesion	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t000665001.1	biological_process	GO:2000047	regulation of cell-cell adhesion mediated by cadherin	"Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]	OMA
NV2t000665001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t000665001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t000665001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t000665002.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t000667001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000668001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000668001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000668001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000668002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000668002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000668002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000668003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000668003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t000668003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000668003.1	biological_process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	"Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]	PANTHER
NV2t000668003.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t000668003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000668004.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000668004.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000668004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000668005.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000668005.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000668005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000668006.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000668006.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000668006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000668007.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000668007.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000668007.1	biological_process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	"Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]	PANTHER
NV2t000668007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000670001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000672003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000674001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t000674001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t000674001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000674001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000674001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000674001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000675001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t000675001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000675002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t000675002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000676001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t000676001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000678001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000678002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000679001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t000679001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000679001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t000679001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t000680001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000680001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t000680001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000680001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t000680001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000680001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000681001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t000681001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000681002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t000681002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000681003.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t000681003.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t000681003.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t000681003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000681003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t000681004.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t000681005.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t000681005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000683002.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t000683002.1	biological_process	GO:0000729	DNA double-strand break processing	"The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855]	OMA
NV2t000683002.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t000683002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000683002.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t000683002.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	OMA
NV2t000683002.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t000683002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t000683002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000683002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000683002.1	molecular_function	GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]	OMA
NV2t000683002.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t000683002.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t000683002.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t000683002.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t000684001.1	biological_process	GO:0002682	regulation of immune system process	"Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t000684001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000684001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000684001.1	biological_process	GO:0009617	response to bacterium	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]	OMA
NV2t000684001.1	biological_process	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	OMA
NV2t000684001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t000684001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t000684001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t000684001.1	biological_process	GO:0031325	positive regulation of cellular metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t000684001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t000684001.1	biological_process	GO:0035331	negative regulation of hippo signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]	OMA
NV2t000684001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t000684001.1	biological_process	GO:0038066	p38MAPK cascade	"A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:20811974, PMID:23125017, PMID:32794416]	OMA
NV2t000684001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t000684001.1	biological_process	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t000684001.1	biological_process	GO:0051155	positive regulation of striated muscle cell differentiation	"Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]	OMA
NV2t000684001.1	biological_process	GO:0051173	obsolete positive regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t000684001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t000684001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t000684001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t000684001.1	biological_process	GO:1901739	regulation of myoblast fusion	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]	OMA
NV2t000684001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000684001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000684001.1	molecular_function	GO:0004707	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	OMA
NV2t000684001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000684001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000684001.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	OMA
NV2t000685001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t000685001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t000685001.1	molecular_function	GO:0017150	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H." [PMID:11983710, PMID:22123979]	PANTHER
NV2t000685001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t000685001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t000685001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t000686001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t000686001.1	cellular_component	GO:1990726	Lsm1-7-Pat1 complex	"A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]	PANTHER
NV2t000686001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t000686001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t000687001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000687001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t000690001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000690001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t000692001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000692001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t000692001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t000692001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t000693001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000694001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000694002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000694003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000694004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000694005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000694006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000696001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000699001.1	biological_process	GO:0000904	obsolete cell morphogenesis involved in differentiation	"OBSOLETE. The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators]	OMA
NV2t000699001.1	biological_process	GO:0002064	epithelial cell development	"The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]	OMA
NV2t000699001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t000699001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t000699001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t000699001.1	biological_process	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	OMA
NV2t000699001.1	biological_process	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	OMA
NV2t000699001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000699001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000699001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t000699001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000699001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t000699001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t000702001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000702001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000702002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000702002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000702003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000702003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000702004.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000702004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000702005.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000702005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000702006.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000702006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000704001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000704001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t000704001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t000704001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t000704002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t000704002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t000705001.1	biological_process	GO:0019321	pentose metabolic process	"The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t000705001.1	biological_process	GO:0046835	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	PANTHER
NV2t000705001.1	biological_process	GO:0070050	neuron cellular homeostasis	"The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]	OMA
NV2t000705001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000705001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000705001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t000705001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t000705001.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t000706001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t000706001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t000707001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000707001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000708002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000708002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t000711001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t000711001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t000711001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000711001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000712001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t000712001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000714001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t000714001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t000714001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000714001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000715001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t000715001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000715001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000720001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t000720001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	PANTHER
NV2t000720002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t000720002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t000720002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	PANTHER
NV2t000722001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t000722001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t000722001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t000722001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t000722001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t000722001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t000722001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t000722001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000722001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t000722001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t000722001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t000722002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t000722002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t000728001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t000728001.1	biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]	OMA
NV2t000728001.1	biological_process	GO:0033233	regulation of protein sumoylation	"Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]	OMA
NV2t000728001.1	biological_process	GO:1902073	positive regulation of hypoxia-inducible factor-1alpha signaling pathway	"Any process that activates or increases the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie, PMID:21685248]	InterPro
NV2t000728001.1	biological_process	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t000728001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000728002.1	biological_process	GO:1902073	positive regulation of hypoxia-inducible factor-1alpha signaling pathway	"Any process that activates or increases the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie, PMID:21685248]	InterPro
NV2t000728002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000729001.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	OMA
NV2t000729001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t000729001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t000729001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t000729001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t000729001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t000729001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	OMA
NV2t000729001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t000730001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000730001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t000730001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t000730001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t000730001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t000730001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t000730001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000730001.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t000731001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t000731001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000731001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t000731001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000731001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t000731001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t000731001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000731001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000732001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t000732001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000732001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t000732001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t000733001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t000733001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000735001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000735001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000737001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000742001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t000742001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t000742001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t000742001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t000742001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	OMA
NV2t000742001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t000742001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000742001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000742001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000742001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t000742001.1	cellular_component	GO:0071818	BAT3 complex	"A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303]	PANTHER
NV2t000742001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000742001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t000743001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000744001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t000744001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t000744001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	PANTHER
NV2t000744001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000744002.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	PANTHER
NV2t000744002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000746001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t000746001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t000746001.1	cellular_component	GO:0045259	proton-transporting ATP synthase complex	"A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663]	OMA
NV2t000746001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t000746001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t000746001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	InterPro
NV2t000746001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	PANTHER
NV2t000748001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t000750001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t000750001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t000750001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t000750001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t000750001.1	cellular_component	GO:0034399	nuclear periphery	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]	OMA
NV2t000750001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t000753001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t000753001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000753001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t000753001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t000753001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t000753001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t000753001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t000754001.1	biological_process	GO:0006548	histidine catabolic process	"The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]	InterPro
NV2t000754001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t000754001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000754001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t000754001.1	molecular_function	GO:0016840	carbon-nitrogen lyase activity	"Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]	OMA
NV2t000754001.1	molecular_function	GO:0016841	ammonia-lyase activity	"Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc]	InterPro
NV2t000754001.1	molecular_function	GO:0016841	ammonia-lyase activity	"Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc]	PANTHER
NV2t000755001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t000755001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t000755001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t000755001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t000756001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t000756001.1	molecular_function	GO:0016153	urocanate hydratase activity	"Catalysis of the reaction: 4-imidazolone-5-propanoate + H+ = trans-urocanate + H2O." [EC:4.2.1.49, RHEA:13101]	InterPro
NV2t000756001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t000757001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000757001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t000757001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000757001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t000757001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000757001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000758001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000758001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t000758001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t000758001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000758001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000761001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000761001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t000761001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t000761001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t000761001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000761001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t000761001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000761001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000771001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t000771001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t000771001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000773001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000773002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000773003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000773004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000778001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000778001.1	biological_process	GO:1902807	negative regulation of cell cycle G1/S phase transition	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]	OMA
NV2t000778001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000778001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000778001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t000779001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000779001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t000779001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t000780001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t000780001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t000780001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000780001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t000780001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t000780001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	PANTHER
NV2t000782001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t000782001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000782001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000782002.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t000782002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000782002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000782003.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t000782003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000782003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000782004.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t000782004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000782004.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	InterPro
NV2t000782005.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t000782005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000782005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000785001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000786001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t000786001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t000786001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t000786001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t000786001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000786001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000786001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000786001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t000788001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t000789001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000789001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000789001.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	PANTHER
NV2t000789002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000789002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000789002.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	PANTHER
NV2t000792001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t000792001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000792002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t000792002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t000792002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t000792002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000792002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t000792002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t000792002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t000792002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t000793001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000793001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t000793001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t000793001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t000793001.1	molecular_function	GO:0030247	polysaccharide binding	"Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]	InterPro
NV2t000795001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000795002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000795002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t000795002.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t000795003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000795004.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000795005.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000795006.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000798002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000798002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t000798002.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t000799001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000799001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t000799001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t000800001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000800001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t000800001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t000800002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000800003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t000801001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000801001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000801002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000801002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000801003.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000801003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000801004.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000801004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000801005.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000801005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000801006.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000801006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000805001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000806001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000806001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t000807001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000807001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t000807001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t000807001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t000807001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t000807001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t000807001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000807001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000808001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t000808001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t000808001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t000808001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000808002.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t000808002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t000808002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t000808002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000809001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000809001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000809001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000810004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t000810004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t000814001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t000814002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t000814002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000814002.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t000817001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t000817001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000817001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t000817001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t000818001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000818001.1	biological_process	GO:0043271	negative regulation of monoatomic ion transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]	PANTHER
NV2t000818001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t000819001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t000819001.1	molecular_function	GO:0004022	alcohol dehydrogenase (NAD+) activity	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]	InterPro
NV2t000819001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000822001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	OMA
NV2t000822001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000822001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000822001.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	InterPro
NV2t000822001.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	PANTHER
NV2t000822001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t000822001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t000822001.1	molecular_function	GO:0008452	RNA ligase activity	"Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the phosphate group at the end of another." [GOC:mah]	InterPro
NV2t000822001.1	molecular_function	GO:0016886	ligase activity, forming phosphoric ester bonds	"Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5.-.-, GOC:mah]	OMA
NV2t000822001.1	molecular_function	GO:0140098	catalytic activity, acting on RNA	"Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t000823001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t000823001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t000823001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000824001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t000824001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t000824001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000824001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000824001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000824002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t000824002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t000824002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t000824002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000824002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000824003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t000824003.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t000824003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000825001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000825002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000826001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t000826001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t000826001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	InterPro
NV2t000826001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t000826001.1	molecular_function	GO:0047499	calcium-independent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+." [EC:3.1.1.4]	PANTHER
NV2t000826002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t000826002.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	InterPro
NV2t000826002.1	molecular_function	GO:0047499	calcium-independent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+." [EC:3.1.1.4]	PANTHER
NV2t000829001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000829001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t000829001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000829003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000829003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t000829003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000829004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t000829004.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t000829004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000830001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t000830001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t000830001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t000830001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t000833001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t000833001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t000833002.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t000835001.1	biological_process	GO:0018022	peptidyl-lysine methylation	"The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]	OMA
NV2t000835001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000835001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000835001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t000835001.1	molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]	OMA
NV2t000835001.1	molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]	PANTHER
NV2t000836001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t000836001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000840001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t000840001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000840001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000841001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t000841001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000841001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000842001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t000842001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000842001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000842001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t000842001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t000843001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000843001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000844001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t000844001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000845001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000847001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t000847001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000849001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t000863001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000863001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000863001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000864001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000866001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t000866001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000866001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000866001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000869001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t000869001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000871001.1	biological_process	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	"The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]	PANTHER
NV2t000874001.1	biological_process	GO:0001881	receptor recycling	"The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph]	OMA
NV2t000874001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t000874001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t000874001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t000874001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t000874001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t000875001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t000875001.1	biological_process	GO:0046949	fatty-acyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]	OMA
NV2t000875001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t000875001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t000875001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	OMA
NV2t000875001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t000875001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t000875001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t000875001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t000875001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t000875001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t000875001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t000875001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t000876001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t000876001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t000876001.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t000876001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t000876001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t000876001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000876001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t000878001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000878002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000880001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t000880001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t000880001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000880001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t000882001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t000882001.1	biological_process	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	PANTHER
NV2t000882001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t000882002.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t000886001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t000886001.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	OMA
NV2t000886001.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t000886001.1	biological_process	GO:0048753	pigment granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]	OMA
NV2t000886001.1	biological_process	GO:0050848	regulation of calcium-mediated signaling	"Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai]	OMA
NV2t000886001.1	biological_process	GO:0051650	establishment of vesicle localization	"The directed movement of a vesicle to a specific location." [GOC:ai]	OMA
NV2t000886001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t000886001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t000886001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t000886001.1	cellular_component	GO:0090741	pigment granule membrane	"Any membrane that is part of a pigment granule." [PMID:11294610]	OMA
NV2t000886001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t000886001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t000886001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t000886001.1	molecular_function	GO:0072341	modified amino acid binding	"Binding to a modified amino acid." [GOC:mah]	OMA
NV2t000886001.1	molecular_function	GO:0072545	L-tyrosine binding	"Binding to L-tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:mah]	InterPro
NV2t000886001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t000889001.1	biological_process	GO:0031591	wybutosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]	PANTHER
NV2t000890001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000890002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t000890002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000890002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t000890002.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t000890002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000891001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t000891002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t000891002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t000891002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000891002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t000891002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t000891003.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t000891003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t000892001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000892001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t000892001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000892001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t000892001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t000892001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000892001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000895001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t000895001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t000898001.1	biological_process	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t000898001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	InterPro
NV2t000898001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t000903001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000903002.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000903003.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000904001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000904002.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000906001.1	biological_process	GO:0071542	dopaminergic neuron differentiation	"The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph]	PANTHER
NV2t000907001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000907002.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000907003.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000907004.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000907005.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t000910001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t000910001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000910001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000910001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t000910001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t000910001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t000910001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t000910001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t000910001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t000913001.1	molecular_function	GO:0004721	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]	OMA
NV2t000913001.1	molecular_function	GO:0004721	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]	PANTHER
NV2t000913001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t000913002.1	molecular_function	GO:0004721	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]	PANTHER
NV2t000913002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t000914001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t000914001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	InterPro
NV2t000914001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	PANTHER
NV2t000916001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t000916001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000919001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t000919001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000919002.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t000919002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000919003.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t000919003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000919004.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t000919004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000922001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	OMA
NV2t000922001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000922001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t000922002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000923001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	OMA
NV2t000923001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000923001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t000924001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t000925001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t000925001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000925001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t000925001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t000926001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t000926001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t000926001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000926001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000926001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t000926001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t000926001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t000926001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t000926001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t000926001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t000926001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t000928001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t000928001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t000928001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000928001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000928001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t000928001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t000928001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t000928001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t000928001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t000928001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t000928001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t000930001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t000930001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000930001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000931001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t000931001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000931001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t000932001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t000932001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t000932001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000932001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000932001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t000932001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t000932001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t000932001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t000932001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t000932001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t000932001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t000933001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000933001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000934001.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	InterPro
NV2t000934001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t000934002.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	OMA
NV2t000934002.1	cellular_component	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	OMA
NV2t000934002.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	InterPro
NV2t000934002.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t000935002.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t000935002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000935002.1	molecular_function	GO:0051920	peroxiredoxin activity	"Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]	InterPro
NV2t000935003.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t000935003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000935004.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t000935004.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t000935004.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t000935004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000935004.1	molecular_function	GO:0051920	peroxiredoxin activity	"Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]	InterPro
NV2t000935004.1	molecular_function	GO:0051920	peroxiredoxin activity	"Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]	OMA
NV2t000936002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000937001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t000937001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t000937002.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t000942001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000942001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t000942001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000942002.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t000942002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000942002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t000942002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t000942002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t000942002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t000942002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000942002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t000942002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t000942002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000943001.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t000943001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000943001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t000943002.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t000943002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000943003.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t000943003.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000943004.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t000943004.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000943005.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t000943005.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000943006.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t000943006.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t000944001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t000944001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t000944001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t000944001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000944001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000945001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t000945001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t000945001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t000945001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000945001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000946001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t000946001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t000946001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000946001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t000946001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t000946001.1	cellular_component	GO:0070603	SWI/SNF superfamily-type complex	"A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]	OMA
NV2t000946001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t000946001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000946001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000946001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t000946001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	InterPro
NV2t000946001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t000946001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t000946001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t000949001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t000949001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t000949001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000949001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t000952001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t000952001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t000952001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t000952001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t000952001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t000952001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t000952001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t000954001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t000954001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t000954001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000954001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t000954001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000954001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t000954001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t000954002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000954002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000954002.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t000954003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t000954003.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t000955001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t000955001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t000955001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t000955001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000955002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t000955002.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t000955002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000957001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000958001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t000959001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t000959001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000959001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t000959001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t000959001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t000959001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t000959001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t000959001.1	molecular_function	GO:0070008	serine-type exopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]	InterPro
NV2t000961001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t000961001.1	biological_process	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah, PMID:16959963]	OMA
NV2t000961001.1	biological_process	GO:0036159	inner dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t000961001.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t000961001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t000961001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t000961001.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t000961001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000961001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t000961001.1	molecular_function	GO:0045503	dynein light chain binding	"Binding to a light chain of the dynein complex." [GOC:bf]	OMA
NV2t000961001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	OMA
NV2t000962001.1	biological_process	GO:0000245	spliceosomal complex assembly	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]	OMA
NV2t000962001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t000962001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t000962001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t000962001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t000962001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t000962001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t000962001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000962001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t000962001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t000962002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t000962002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000962002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t000963001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t000963001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t000963001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t000963001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000963001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t000963001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t000963001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t000963001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t000963001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t000967001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t000968001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t000968001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t000970001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	InterPro
NV2t000970001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	OMA
NV2t000970001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t000970001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t000973001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t000973001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t000973001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t000976001.1	biological_process	GO:0000132	establishment of mitotic spindle orientation	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]	OMA
NV2t000976001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t000976001.1	molecular_function	GO:0001965	G-protein alpha-subunit binding	"Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]	OMA
NV2t000976001.1	molecular_function	GO:0005092	GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]	OMA
NV2t000976001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000977001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000977001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t000983001.1	biological_process	GO:0007019	microtubule depolymerization	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]	OMA
NV2t000983001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t000983001.1	cellular_component	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	OMA
NV2t000983001.1	cellular_component	GO:0008352	katanin complex	"A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]	PANTHER
NV2t000984001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t000984001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t000984001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t000984001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t000984001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t000984001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000984001.1	molecular_function	GO:0031624	ubiquitin conjugating enzyme binding	"Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]	OMA
NV2t000984001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000984001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t000984001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t000984002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t000984002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t000984002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t000985001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	PANTHER
NV2t000985002.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	PANTHER
NV2t000986001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t000986001.1	biological_process	GO:0000578	embryonic axis specification	"The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]	OMA
NV2t000986001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t000986001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t000986001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t000986001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t000986001.1	biological_process	GO:0007507	heart development	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]	OMA
NV2t000986001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t000986001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t000986001.1	biological_process	GO:0009953	dorsal/ventral pattern formation	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t000986001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t000986001.1	biological_process	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	OMA
NV2t000986001.1	biological_process	GO:0032370	positive regulation of lipid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t000986001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t000986001.1	biological_process	GO:0035107	appendage morphogenesis	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]	OMA
NV2t000986001.1	biological_process	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	OMA
NV2t000986001.1	biological_process	GO:0036315	cellular response to sterol	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [GOC:bf]	OMA
NV2t000986001.1	biological_process	GO:0040015	negative regulation of multicellular organism growth	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]	OMA
NV2t000986001.1	biological_process	GO:0043433	negative regulation of DNA-binding transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]	OMA
NV2t000986001.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t000986001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t000986001.1	biological_process	GO:0045879	negative regulation of smoothened signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t000986001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t000986001.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t000986001.1	biological_process	GO:0048878	chemical homeostasis	"Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete]	OMA
NV2t000986001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t000986001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t000986001.1	biological_process	GO:0097306	cellular response to alcohol	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr]	OMA
NV2t000986001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t000986001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t000986001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000986001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t000986001.1	cellular_component	GO:0045177	apical part of cell	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]	OMA
NV2t000986001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t000986001.1	cellular_component	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	OMA
NV2t000986001.1	molecular_function	GO:0005119	smoothened binding	"Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473]	OMA
NV2t000986001.1	molecular_function	GO:0008158	hedgehog receptor activity	"Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137]	OMA
NV2t000986001.1	molecular_function	GO:0015485	cholesterol binding	"Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]	OMA
NV2t000986001.1	molecular_function	GO:0030332	cyclin binding	"Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]	OMA
NV2t000986001.1	molecular_function	GO:0097108	hedgehog family protein binding	"Binding to a member of the hedgehog protein family, signaling proteins involved in development." [GOC:BHF, GOC:pr, PMID:10050855]	OMA
NV2t000986001.1	molecular_function	GO:0097108	hedgehog family protein binding	"Binding to a member of the hedgehog protein family, signaling proteins involved in development." [GOC:BHF, GOC:pr, PMID:10050855]	PANTHER
NV2t000988003.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t000988003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t000988003.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t000988003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t000989001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t000989001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t000989001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t000989001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t000989001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t000989001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t000991001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t000993001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t000993001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000993001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000993001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000993001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t000993001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t000993001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t000995001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t000995001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t000995001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t000995001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t000995001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t000995001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t001014001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t001014001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	InterPro
NV2t001014001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t001014001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001014001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001015001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t001015001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001015001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001015001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001015001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t001015001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t001015002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001015002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001017001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t001017001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t001017001.1	biological_process	GO:0048753	pigment granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]	OMA
NV2t001017001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t001017001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t001017001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	InterPro
NV2t001017001.1	cellular_component	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	OMA
NV2t001017001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t001017001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001017001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001020001.1	biological_process	GO:0000338	protein deneddylation	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]	OMA
NV2t001020001.1	biological_process	GO:0016926	protein desumoylation	"The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250]	OMA
NV2t001020001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001020001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001020001.1	molecular_function	GO:0016929	deSUMOylase activity	"An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250, PMID:23746258]	OMA
NV2t001020001.1	molecular_function	GO:0019784	deNEDDylase activity	"An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated." [GOC:mah, PMID:25628956]	InterPro
NV2t001020001.1	molecular_function	GO:0019784	deNEDDylase activity	"An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated." [GOC:mah, PMID:25628956]	OMA
NV2t001021001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t001021001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t001021001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t001021001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001023001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001023001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001023001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001023001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t001024001.1	biological_process	GO:2001256	regulation of store-operated calcium entry	"Any process that modulates the frequency, rate or extent of store-operated calcium entry." [GOC:BHF]	InterPro
NV2t001025001.1	biological_process	GO:0006898	receptor-mediated endocytosis	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]	OMA
NV2t001025001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t001025001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t001025001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t001025001.1	biological_process	GO:0042632	cholesterol homeostasis	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]	OMA
NV2t001025001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t001025001.1	biological_process	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	OMA
NV2t001025001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t001025001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001025001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001025001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001025001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001025001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001025001.1	molecular_function	GO:0030228	lipoprotein particle receptor activity	"Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:bf, GOC:mah, PMID:12827279]	OMA
NV2t001025001.1	molecular_function	GO:0071813	lipoprotein particle binding	"Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:BHF, GOC:mah]	OMA
NV2t001025003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001025003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001025003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001026001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001026001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001026001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t001026001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	PANTHER
NV2t001026001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t001026001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001026001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t001026001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001026002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001026002.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	PANTHER
NV2t001026002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001029001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t001029001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	InterPro
NV2t001029001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t001029001.1	biological_process	GO:0006335	DNA replication-dependent chromatin assembly	"The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation." [GOC:mah, PMID:28053344]	OMA
NV2t001029001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001029001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t001029001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t001029001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t001029001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t001031001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001031001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t001031001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001031001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001031001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001031001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t001031001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001031001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001032001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001032001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001032001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001032001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001032001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001033001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001033001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001033001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t001033001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001034001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001034001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t001034001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001034001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001034001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t001034001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001034001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001035001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001035001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001035001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001035001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001035001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001035002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001035002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001035002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001035002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001035002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001037001.1	biological_process	GO:0046599	regulation of centriole replication	"Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]	OMA
NV2t001037001.1	biological_process	GO:0051310	metaphase chromosome alignment	"A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [GOC:vw]	OMA
NV2t001037001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	InterPro
NV2t001037001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	OMA
NV2t001037001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t001037001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t001037001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t001038001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t001038001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t001038001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t001038001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t001038001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001038001.1	cellular_component	GO:0048500	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	InterPro
NV2t001038001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t001038001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001038002.1	cellular_component	GO:0048500	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	InterPro
NV2t001038003.1	cellular_component	GO:0048500	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	InterPro
NV2t001039001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	OMA
NV2t001039001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t001039001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t001039001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t001039001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001040001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001040001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t001040001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001040001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001040001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001040001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t001040001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001040001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001041001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001041001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001046001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001046002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001046003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001049001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	PANTHER
NV2t001051001.1	biological_process	GO:0010942	obsolete positive regulation of cell death	"OBSOLETE. Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]	OMA
NV2t001051001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t001051001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001051001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t001051001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001051001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t001051001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t001051001.1	molecular_function	GO:0051059	NF-kappaB binding	"Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]	OMA
NV2t001053001.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t001053001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001053002.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t001053003.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t001053003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001053004.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t001053004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001053005.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t001053005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001053006.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t001054001.1	molecular_function	GO:0004519	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t001054001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001054002.1	biological_process	GO:0006935	chemotaxis	"The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]	OMA
NV2t001054002.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t001054002.1	biological_process	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	OMA
NV2t001054002.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t001054002.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t001054002.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t001054002.1	biological_process	GO:0046503	glycerolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t001054002.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t001054002.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t001054002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t001054002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t001054002.1	molecular_function	GO:0004527	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	OMA
NV2t001054002.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	OMA
NV2t001054002.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t001054002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001054002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t001054002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001054002.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t001054002.1	molecular_function	GO:0030247	polysaccharide binding	"Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]	OMA
NV2t001054002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001054003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001055001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001056001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001057001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001057001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001057001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001057001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001057002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001057002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001057002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001069001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001069001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001069001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001069002.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001069002.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001069002.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t001069002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001069002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001069002.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t001069003.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001069003.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001069003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001069004.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001069004.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001069004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001069005.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001069005.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001069005.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001069006.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001069006.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001069006.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001069007.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001069007.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001069007.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001069008.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001069008.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001069008.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001071001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001073001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001078001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t001078001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t001078001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t001078001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001078001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t001080001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001086001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t001086001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001086001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t001087001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001088001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	PANTHER
NV2t001090001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t001090001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t001090001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t001090001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t001090001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001090001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001090001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001090001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t001091001.1	biological_process	GO:0001933	negative regulation of protein phosphorylation	"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t001091001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t001091001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t001091001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	PANTHER
NV2t001091001.1	biological_process	GO:0016239	positive regulation of macroautophagy	"Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]	OMA
NV2t001091001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	OMA
NV2t001091001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t001091001.1	biological_process	GO:0048675	axon extension	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]	OMA
NV2t001091001.1	biological_process	GO:0110053	regulation of actin filament organization	"Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv]	OMA
NV2t001091001.1	biological_process	GO:1902774	late endosome to lysosome transport	"The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442]	OMA
NV2t001091001.1	biological_process	GO:1903432	regulation of TORC1 signaling	"Any process that modulates the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie]	OMA
NV2t001091001.1	biological_process	GO:2000785	regulation of autophagosome assembly	"Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t001091001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t001091001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t001091001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001091001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t001091001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t001091001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t001091001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t001091001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t001091001.1	cellular_component	GO:0032045	guanyl-nucleotide exchange factor complex	"A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah]	OMA
NV2t001091001.1	cellular_component	GO:0043204	perikaryon	"The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl]	OMA
NV2t001091001.1	cellular_component	GO:0044295	axonal growth cone	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]	OMA
NV2t001091001.1	cellular_component	GO:0044304	main axon	"The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites." [NIF_Subcellular:sao1596975044]	OMA
NV2t001091001.1	cellular_component	GO:1990316	Atg1/ULK1 kinase complex	"A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]	OMA
NV2t001091001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t001091001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t001091001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t001091002.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	PANTHER
NV2t001091002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t001092001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t001092001.1	biological_process	GO:0010212	response to ionizing radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]	OMA
NV2t001092001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t001092001.1	biological_process	GO:0045003	double-strand break repair via synthesis-dependent strand annealing	"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]	OMA
NV2t001092001.1	biological_process	GO:0045003	double-strand break repair via synthesis-dependent strand annealing	"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]	PANTHER
NV2t001092001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001092001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t001092001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001092001.1	molecular_function	GO:0015616	DNA translocase activity	"Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis." [GOC:mah, PMID:16428451, PMID:17631491]	OMA
NV2t001092001.1	molecular_function	GO:0016817	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	OMA
NV2t001092001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t001092001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t001092002.1	biological_process	GO:0045003	double-strand break repair via synthesis-dependent strand annealing	"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]	PANTHER
NV2t001092002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t001094001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t001094001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001094001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001095001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t001095001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t001095001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001095001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001095001.1	molecular_function	GO:0009975	cyclase activity	"Catalysis of a ring closure reaction." [ISBN:0198547684]	OMA
NV2t001095001.1	molecular_function	GO:0016886	ligase activity, forming phosphoric ester bonds	"Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5.-.-, GOC:mah]	OMA
NV2t001095001.1	molecular_function	GO:0140098	catalytic activity, acting on RNA	"Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t001095002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t001095002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001096001.1	biological_process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	OMA
NV2t001096001.1	biological_process	GO:0000291	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]	OMA
NV2t001096001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t001096001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t001096001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t001096001.1	biological_process	GO:0006304	DNA modification	"The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]	OMA
NV2t001096001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t001096001.1	biological_process	GO:0016078	tRNA decay	"The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai]	OMA
NV2t001096001.1	biological_process	GO:0016444	somatic cell DNA recombination	"Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]	OMA
NV2t001096001.1	biological_process	GO:0031125	rRNA 3'-end processing	"Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah]	OMA
NV2t001096001.1	biological_process	GO:0031126	sno(s)RNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea." [GOC:krc, GOC:mah, PMID:17284456]	OMA
NV2t001096001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t001096001.1	biological_process	GO:0043634	polyadenylation-dependent ncRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc]	OMA
NV2t001096001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t001096001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t001096001.1	biological_process	GO:0071027	nuclear RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]	OMA
NV2t001096001.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t001096001.1	biological_process	GO:0090503	obsolete RNA phosphodiester bond hydrolysis, exonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	OMA
NV2t001096001.1	cellular_component	GO:0000176	nuclear exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t001096001.1	cellular_component	GO:0000791	euchromatin	"A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]	OMA
NV2t001096001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001096001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001096001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001096001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001098001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t001098001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	PANTHER
NV2t001099001.1	biological_process	GO:0034312	diol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah]	OMA
NV2t001099001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t001099001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t001099001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	PANTHER
NV2t001099001.1	biological_process	GO:1904504	positive regulation of lipophagy	"Any process that activates or increases the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539]	OMA
NV2t001099001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t001099001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t001099001.1	molecular_function	GO:0004758	serine C-palmitoyltransferase activity	"Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA." [EC:2.3.1.50, RHEA:14761]	OMA
NV2t001099001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t001099001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t001100001.1	biological_process	GO:0006779	porphyrin-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]	InterPro
NV2t001100001.1	biological_process	GO:0006783	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]	PANTHER
NV2t001100001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t001100001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t001100001.1	biological_process	GO:0019439	obsolete aromatic compound catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t001100001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t001100001.1	biological_process	GO:0044270	obsolete cellular nitrogen compound catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t001100001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t001100001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t001100001.1	biological_process	GO:0046700	obsolete heterocycle catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]	OMA
NV2t001100001.1	biological_process	GO:1901361	organic cyclic compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t001100001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t001100001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t001100001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t001100001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001100001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t001100001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t001103001.1	biological_process	GO:0006084	acetyl-CoA metabolic process	"The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]	OMA
NV2t001103001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t001103001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t001103001.1	biological_process	GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	"The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922]	InterPro
NV2t001103001.1	biological_process	GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	"The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922]	PANTHER
NV2t001103001.1	biological_process	GO:0016114	terpenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]	OMA
NV2t001103001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001103001.1	molecular_function	GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	OMA
NV2t001104001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t001104001.1	cellular_component	GO:0005575	cellular_component	"A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt]	OMA
NV2t001104001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	OMA
NV2t001104001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	PANTHER
NV2t001105001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001105002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001105003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001108001.1	biological_process	GO:0006491	N-glycan processing	"The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]	OMA
NV2t001108001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t001108001.1	biological_process	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	OMA
NV2t001108001.1	cellular_component	GO:0017177	glucosidase II complex	"A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]	PANTHER
NV2t001108001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t001108001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t001108001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001108001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001108002.1	cellular_component	GO:0017177	glucosidase II complex	"A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]	PANTHER
NV2t001108002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001108003.1	cellular_component	GO:0017177	glucosidase II complex	"A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]	PANTHER
NV2t001108003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001109001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t001109001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t001109001.1	biological_process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	"Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]	PANTHER
NV2t001109001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001113001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001114001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001116001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t001116001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001117001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t001117001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t001117001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t001117001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t001117001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001117001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001119001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t001120001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001120001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001120001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t001120001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t001120001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t001120001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t001120001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001120001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001120001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001122001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t001122002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t001122003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t001123002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001123002.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t001123002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t001123002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001123003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001123003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001123004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001123004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001123004.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t001123004.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t001123004.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t001123004.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t001123004.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001123004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001123005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001123005.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t001123005.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t001123005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001124001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001124001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001124001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t001124001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t001124001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t001124001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001124001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001125001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t001125001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001125001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	OMA
NV2t001125001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t001125001.1	biological_process	GO:1902603	carnitine transmembrane transport	"The directed movement of carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t001125001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001125001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001126001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t001126001.1	biological_process	GO:0043044	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	PANTHER
NV2t001126001.1	cellular_component	GO:0070603	SWI/SNF superfamily-type complex	"A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]	OMA
NV2t001126001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	InterPro
NV2t001126001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t001126001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001126002.1	biological_process	GO:0043044	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	PANTHER
NV2t001126002.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	InterPro
NV2t001129001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t001130001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001130001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001130001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001130001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001131001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t001131001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t001133001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001133001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001133001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001133001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001136001.1	biological_process	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	InterPro
NV2t001136001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	InterPro
NV2t001136001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t001136001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001136001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t001136001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t001137001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t001137001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t001137001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t001137001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001139001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t001139001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t001139001.1	biological_process	GO:0051298	centrosome duplication	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]	OMA
NV2t001139001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	OMA
NV2t001139001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	PANTHER
NV2t001139001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t001139001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t001140001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t001140001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t001144001.1	biological_process	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t001144001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001144001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t001144001.1	biological_process	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t001144001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001144001.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	InterPro
NV2t001144001.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	OMA
NV2t001144001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t001144001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001144001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001144001.1	molecular_function	GO:0030295	protein kinase activator activity	"Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t001144002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001144002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001144002.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	InterPro
NV2t001144002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001144003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001144003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001144003.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	InterPro
NV2t001144003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001145001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t001145001.1	cellular_component	GO:0070876	SOSS complex	"A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501]	InterPro
NV2t001145001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t001146001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t001146001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t001146001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t001146002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t001151001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001153001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t001153001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001153001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001153001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001153001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001155001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t001155001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t001155001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001155001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001156001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t001156001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t001156001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t001156001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t001156001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t001156001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001157001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t001157001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001157001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001157001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	InterPro
NV2t001157001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t001158001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t001158002.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t001162001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t001162001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t001162001.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	OMA
NV2t001162001.1	biological_process	GO:0043407	negative regulation of MAP kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t001162001.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t001162001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001162001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t001162001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t001162001.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t001162001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t001162001.1	molecular_function	GO:0033549	MAP kinase phosphatase activity	"Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316]	OMA
NV2t001163001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t001163001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t001167001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t001167001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t001167001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t001167001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001167001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t001167001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t001167001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001167001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001167002.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t001167002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001168001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t001168001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001169001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t001169001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t001169002.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t001169003.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t001169003.1	biological_process	GO:0014074	response to purine-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:ef]	OMA
NV2t001169003.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t001169003.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	OMA
NV2t001169003.1	biological_process	GO:0046683	response to organophosphorus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]	OMA
NV2t001169003.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	OMA
NV2t001169003.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t001169003.1	biological_process	GO:0071417	cellular response to organonitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah]	OMA
NV2t001169003.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t001169003.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t001169003.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t001169003.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t001169003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001169003.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t001169003.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t001169003.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t001169003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001169003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001169003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t001169003.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t001169003.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t001169003.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t001169003.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t001169003.1	molecular_function	GO:0070325	lipoprotein particle receptor binding	"Binding to a lipoprotein particle receptor." [GOC:BHF, GOC:rl]	OMA
NV2t001169003.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t001170001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001171001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t001171001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001173001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t001173001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t001173001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001173001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t001173001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t001175001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001177001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t001177001.1	molecular_function	GO:0042134	rRNA primary transcript binding	"Binding to an unprocessed ribosomal RNA transcript." [GOC:jl]	InterPro
NV2t001179001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t001179001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t001179001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t001179001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t001179001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t001180001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t001180001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t001180001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t001180001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t001180001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001180001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001180001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t001181001.1	cellular_component	GO:0070210	Rpd3L-Expanded complex	"A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]	PANTHER
NV2t001181001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001181002.1	cellular_component	GO:0070210	Rpd3L-Expanded complex	"A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]	PANTHER
NV2t001181002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001181003.1	cellular_component	GO:0070210	Rpd3L-Expanded complex	"A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]	PANTHER
NV2t001181003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001181004.1	cellular_component	GO:0070210	Rpd3L-Expanded complex	"A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]	PANTHER
NV2t001181005.1	cellular_component	GO:0070210	Rpd3L-Expanded complex	"A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]	PANTHER
NV2t001181005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001181006.1	cellular_component	GO:0070210	Rpd3L-Expanded complex	"A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]	PANTHER
NV2t001181006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001181007.1	cellular_component	GO:0070210	Rpd3L-Expanded complex	"A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]	PANTHER
NV2t001181007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001183001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001183001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	InterPro
NV2t001183001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	OMA
NV2t001183001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	PANTHER
NV2t001184001.1	biological_process	GO:0016079	synaptic vesicle exocytosis	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]	OMA
NV2t001184001.1	biological_process	GO:1990504	dense core granule exocytosis	"The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208]	InterPro
NV2t001184001.1	biological_process	GO:1990504	dense core granule exocytosis	"The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208]	OMA
NV2t001184002.1	biological_process	GO:1990504	dense core granule exocytosis	"The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208]	InterPro
NV2t001186001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001186001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001186001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t001186001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t001186001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	PANTHER
NV2t001186001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t001186001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t001186001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t001186001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t001186001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t001186001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t001188001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001188001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001188001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t001188001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t001189001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	InterPro
NV2t001189001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t001189001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t001190001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001190001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001191001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	InterPro
NV2t001191001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	PANTHER
NV2t001191001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001191001.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	InterPro
NV2t001191001.1	molecular_function	GO:0016423	tRNA (guanine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [GOC:go-curators]	OMA
NV2t001192001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001193001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t001193001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t001196001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001196001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001196001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001196001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001196001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t001196001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t001196001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t001197001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001197001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001197001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001197001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001197001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t001197001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t001197001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t001200001.1	biological_process	GO:0009314	response to radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]	OMA
NV2t001200001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t001200001.1	biological_process	GO:0043388	positive regulation of DNA binding	"Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]	OMA
NV2t001200001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t001200001.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t001200001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001200001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001200001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001200001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	InterPro
NV2t001200001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t001200001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	PANTHER
NV2t001209001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t001209001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001210001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t001210001.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t001210001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t001210001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t001210001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t001210001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	OMA
NV2t001210001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t001212001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t001212001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t001212001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t001212001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t001212001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t001212001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t001212002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t001214001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t001214001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001214001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t001214001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t001214001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t001214001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t001215001.1	biological_process	GO:0045041	protein import into mitochondrial intermembrane space	"The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363]	PANTHER
NV2t001216001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t001216001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t001216001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t001216001.1	biological_process	GO:0008089	anterograde axonal transport	"The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]	OMA
NV2t001216001.1	biological_process	GO:0008089	anterograde axonal transport	"The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]	PANTHER
NV2t001216001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t001216001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t001216001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t001216001.1	biological_process	GO:0016482	cytosolic transport	"The directed movement of substances or organelles within the cytosol." [GOC:ai]	OMA
NV2t001216001.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	OMA
NV2t001216001.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t001216001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t001216001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	OMA
NV2t001216001.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t001216001.1	biological_process	GO:0044000	obsolete movement in host	"OBSOLETE. The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]	OMA
NV2t001216001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t001216001.1	biological_process	GO:0061909	autophagosome-lysosome fusion	"The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [PMID:28077293]	OMA
NV2t001216001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	OMA
NV2t001216001.1	biological_process	GO:1902774	late endosome to lysosome transport	"The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442]	OMA
NV2t001216001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t001216001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t001216001.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	OMA
NV2t001216001.1	molecular_function	GO:0003925	G protein activity	"A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]	OMA
NV2t001216001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001216001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001216001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	OMA
NV2t001217001.1	biological_process	GO:0034067	protein localization to Golgi apparatus	"A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]	OMA
NV2t001217001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t001217001.1	biological_process	GO:0051642	centrosome localization	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t001217001.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t001217001.1	biological_process	GO:0072384	organelle transport along microtubule	"The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]	OMA
NV2t001217001.1	biological_process	GO:0072393	microtubule anchoring at microtubule organizing center	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938]	OMA
NV2t001217001.1	cellular_component	GO:0005642	annulate lamellae	"Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728]	OMA
NV2t001217001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t001217001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t001217001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t001217001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001217001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t001217001.1	molecular_function	GO:0008093	cytoskeletal anchor activity	"The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238]	OMA
NV2t001217001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t001217001.1	molecular_function	GO:0034452	dynactin binding	"Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah]	OMA
NV2t001217001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t001217001.1	molecular_function	GO:0070840	dynein complex binding	"Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]	InterPro
NV2t001217001.1	molecular_function	GO:0070840	dynein complex binding	"Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]	OMA
NV2t001220001.1	biological_process	GO:0006623	protein targeting to vacuole	"The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t001220001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t001220001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t001220001.1	biological_process	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	OMA
NV2t001220001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t001220001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t001220001.1	biological_process	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t001220001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t001220001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t001220001.1	biological_process	GO:0051050	positive regulation of transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t001220001.1	biological_process	GO:0051650	establishment of vesicle localization	"The directed movement of a vesicle to a specific location." [GOC:ai]	OMA
NV2t001220001.1	biological_process	GO:0060627	regulation of vesicle-mediated transport	"Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]	OMA
NV2t001220001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	OMA
NV2t001220001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t001220001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t001220001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t001220001.1	cellular_component	GO:0045335	phagocytic vesicle	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t001220001.1	cellular_component	GO:0098852	lytic vacuole membrane	"The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]	OMA
NV2t001220001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t001220001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001220001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001220001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001220001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t001222001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t001222001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t001222001.1	biological_process	GO:0009448	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	OMA
NV2t001222001.1	biological_process	GO:0009450	gamma-aminobutyric acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]	InterPro
NV2t001222001.1	biological_process	GO:0009450	gamma-aminobutyric acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]	PANTHER
NV2t001222001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001222001.1	molecular_function	GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [RHEA:13217]	OMA
NV2t001222001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t001222001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t001226001.1	biological_process	GO:0010592	positive regulation of lamellipodium assembly	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]	OMA
NV2t001226001.1	biological_process	GO:0010976	positive regulation of neuron projection development	"Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t001226001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t001226001.1	biological_process	GO:0032507	maintenance of protein location in cell	"Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]	OMA
NV2t001226001.1	biological_process	GO:0045773	positive regulation of axon extension	"Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators]	OMA
NV2t001226001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	OMA
NV2t001226001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t001226001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	OMA
NV2t001226001.1	biological_process	GO:0071396	cellular response to lipid	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]	OMA
NV2t001226001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t001226001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t001226001.1	cellular_component	GO:0030016	myofibril	"The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]	OMA
NV2t001226001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t001226001.1	cellular_component	GO:0030175	filopodium	"Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]	OMA
NV2t001226001.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t001226001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t001226001.1	cellular_component	GO:0098862	cluster of actin-based cell projections	"A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos]	OMA
NV2t001226001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t001226001.1	molecular_function	GO:0003785	actin monomer binding	"Binding to monomeric actin, also known as G-actin." [GOC:ai]	OMA
NV2t001226001.1	molecular_function	GO:0005080	protein kinase C binding	"Binding to protein kinase C." [GOC:jl]	OMA
NV2t001226001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001226001.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t001226001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t001227001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t001227001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t001227001.1	biological_process	GO:0009226	nucleotide-sugar biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]	OMA
NV2t001227001.1	biological_process	GO:0009298	GDP-mannose biosynthetic process	"The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	InterPro
NV2t001227001.1	biological_process	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	OMA
NV2t001227001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001227001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001227001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	PANTHER
NV2t001227001.1	molecular_function	GO:0070568	guanylyltransferase activity	"Catalysis of the transfer of a guanylyl group to an acceptor." [GOC:mah]	OMA
NV2t001228001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001228001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001228001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001228001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001229001.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	PANTHER
NV2t001231001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t001231001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	InterPro
NV2t001231001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t001231001.1	biological_process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]	OMA
NV2t001231001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t001232001.1	biological_process	GO:0000350	generation of catalytic spliceosome for second transesterification step	"Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]	InterPro
NV2t001232001.1	cellular_component	GO:0071020	post-spliceosomal complex	"A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]	PANTHER
NV2t001232002.1	biological_process	GO:0000350	generation of catalytic spliceosome for second transesterification step	"Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]	InterPro
NV2t001232002.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	OMA
NV2t001232002.1	cellular_component	GO:0000974	Prp19 complex	"A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]	OMA
NV2t001232002.1	cellular_component	GO:0071020	post-spliceosomal complex	"A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]	PANTHER
NV2t001232002.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t001232002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t001232002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t001233001.1	biological_process	GO:2000677	regulation of transcription regulatory region DNA binding	"Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]	PANTHER
NV2t001233001.1	molecular_function	GO:0031151	histone H3K79 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351]	InterPro
NV2t001235001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t001235001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001235001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001235001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001235002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001235002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001235003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001235003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001236001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	InterPro
NV2t001236001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001236002.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	InterPro
NV2t001236002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001236003.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	InterPro
NV2t001236003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001237001.1	biological_process	GO:0006693	prostaglandin metabolic process	"The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]	OMA
NV2t001237001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t001237001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t001237001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t001237001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t001237001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001237001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t001242001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001242001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001242002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001242002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001243001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001243001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001243002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001243002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001244001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t001245001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001245001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001246001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001246001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001248001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001248001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t001248001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t001248001.1	molecular_function	GO:0005462	UDP-N-acetylglucosamine transmembrane transporter activity	"Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001248001.1	molecular_function	GO:0005464	UDP-xylose transmembrane transporter activity	"Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai]	OMA
NV2t001253001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001253001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t001253001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t001253001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001253001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001255001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t001255001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t001255001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t001257001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t001257001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t001260001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t001260001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t001262001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	PANTHER
NV2t001265001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t001265001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001265001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001265001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t001265001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t001265001.1	molecular_function	GO:0004890	GABA-A receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]	OMA
NV2t001265001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t001265001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t001265001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t001268001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001269001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001269001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t001269001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t001269001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001269001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001269001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001269001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001269002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001269002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001270001.1	biological_process	GO:0008361	regulation of cell size	"Any process that modulates the size of a cell." [GOC:go_curators]	OMA
NV2t001270001.1	biological_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t001270001.1	biological_process	GO:0061462	protein localization to lysosome	"A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]	OMA
NV2t001270001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t001270001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t001270001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t001270001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t001270001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	InterPro
NV2t001270001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	OMA
NV2t001270001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t001270001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t001271001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001273002.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t001275001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t001275001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t001275001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t001275001.1	molecular_function	GO:0140575	transmembrane monodehydroascorbate reductase activity	"Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction." [PMID:1623014, RHEA:66524]	InterPro
NV2t001276001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t001276001.1	biological_process	GO:0035551	obsolete protein initiator methionine removal involved in protein maturation	"OBSOLETE. Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein." [GOC:bf, GOC:hjd, GOC:vw]	PANTHER
NV2t001276001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t001276001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001276001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t001276001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t001276002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001276003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001276004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001276005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001276006.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001277001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t001277001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t001277001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t001277001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t001277002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t001277002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t001278001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t001278001.1	biological_process	GO:0021782	glial cell development	"The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t001278001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t001278001.1	biological_process	GO:0050890	cognition	"The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908]	OMA
NV2t001278001.1	biological_process	GO:0051960	regulation of nervous system development	"Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	OMA
NV2t001278001.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	PANTHER
NV2t001278001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001278001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t001278001.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	InterPro
NV2t001278001.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	OMA
NV2t001279001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001279001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001279001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001279001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t001279001.1	molecular_function	GO:0015294	solute:monoatomic cation symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai]	OMA
NV2t001280001.1	molecular_function	GO:0019786	protein-phosphatidylethanolamide deconjugating activity	"Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328]	InterPro
NV2t001284001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t001284002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t001287001.1	biological_process	GO:0018126	protein hydroxylation	"The addition of a hydroxy group to a protein amino acid." [GOC:ai]	OMA
NV2t001287001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001287001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001287001.1	molecular_function	GO:0004175	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	OMA
NV2t001287001.1	molecular_function	GO:0004177	aminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]	OMA
NV2t001287001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t001287001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t001287001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t001287001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t001291001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t001293001.1	biological_process	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	"The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783]	OMA
NV2t001293001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t001293001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	OMA
NV2t001293001.1	biological_process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	"Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators]	OMA
NV2t001293001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	OMA
NV2t001293001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	PANTHER
NV2t001293001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t001293001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001293001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001294001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001295001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t001295001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t001295001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001295001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t001295001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t001295001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t001296001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t001296001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t001296002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t001296002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t001296002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001296002.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t001296002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t001296002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t001298001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t001298001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t001298002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t001298002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t001299001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t001299001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001300001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001300001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001300001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t001302001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t001302001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001304001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001304001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001304001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t001304001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t001304002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001304002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001304002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t001304003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001304003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001304003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t001306001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t001306001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t001306001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t001307001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001307001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001311001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001311001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001311002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001311002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001312001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t001312001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001312002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t001312002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001313001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001324001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t001324001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001324001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001324001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t001325001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001325001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001325001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001325001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001329001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001329001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001331001.1	biological_process	GO:0006687	glycosphingolipid metabolic process	"The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]	OMA
NV2t001331001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t001331001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t001331001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	PANTHER
NV2t001331001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t001332001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001332001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001332001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001332001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001335001.1	biological_process	GO:0006687	glycosphingolipid metabolic process	"The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]	OMA
NV2t001335001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t001335001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t001335001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	PANTHER
NV2t001335001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t001337001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001337001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001337001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001337001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001339001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t001339001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001340001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t001340001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t001340001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001340001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t001340001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t001340001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t001341001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t001341001.1	biological_process	GO:0010756	positive regulation of plasminogen activation	"Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t001341001.1	biological_process	GO:0045862	positive regulation of proteolysis	"Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	OMA
NV2t001341001.1	biological_process	GO:0070613	regulation of protein processing	"Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah]	OMA
NV2t001342001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001342001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t001342001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t001342001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001342001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001342001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t001345001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001345001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001345001.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	PANTHER
NV2t001349001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	InterPro
NV2t001349001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	PANTHER
NV2t001350001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t001350001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001351001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001351001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001351001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t001351001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001352001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001352001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001355001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355002.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355002.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355003.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355003.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355004.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t001355004.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355004.1	biological_process	GO:0033119	negative regulation of RNA splicing	"Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah]	OMA
NV2t001355004.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001355004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355004.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t001355005.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355005.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355006.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355006.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355007.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355008.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355008.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355008.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355009.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355009.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355009.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355009.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355010.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355010.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355010.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355010.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355011.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355011.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355011.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355011.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355012.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355012.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355012.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355012.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001355013.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001355013.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t001355013.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001355013.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001356001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t001358001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t001358001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t001358001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t001358001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t001358001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t001358001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t001364001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001364001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t001364001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t001364001.1	biological_process	GO:2000369	regulation of clathrin-dependent endocytosis	"Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:mah]	PANTHER
NV2t001364001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t001364001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001365001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t001365001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t001365001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t001365001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t001365002.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t001365002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t001365003.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t001365003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t001366001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001366001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001366001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001366001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001366002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001366002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001366002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001366002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001368001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t001368001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t001368001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001368001.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	OMA
NV2t001368001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t001368001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t001369001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001369002.1	biological_process	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	OMA
NV2t001369002.1	biological_process	GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t001369002.1	biological_process	GO:0036503	ERAD pathway	"The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]	OMA
NV2t001369002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001369002.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t001369002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001369002.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t001369002.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t001369002.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t001369002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t001369002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001369003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001369003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001369004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001369004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001370001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001370001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t001371001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t001371001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t001371001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t001371001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001371001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t001371001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t001371002.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t001371002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001372001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001372001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001372001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001372001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t001372001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t001372001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t001373001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001373001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001373001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001373001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t001373001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t001373001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t001376001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	OMA
NV2t001376001.1	biological_process	GO:0051455	spindle attachment to meiosis I kinetochore	"The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb]	PANTHER
NV2t001376001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t001376001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t001377001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t001377001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t001377001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t001377001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t001383001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	OMA
NV2t001383001.1	biological_process	GO:1902603	carnitine transmembrane transport	"The directed movement of carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t001383001.1	cellular_component	GO:0005740	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	OMA
NV2t001383001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001387001.1	molecular_function	GO:0004784	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]	OMA
NV2t001387001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t001387001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t001387001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001389001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t001389001.1	molecular_function	GO:0005338	nucleotide-sugar transmembrane transporter activity	"Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]	OMA
NV2t001389001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t001389001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t001390001.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	PANTHER
NV2t001390002.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t001390002.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t001390002.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t001390002.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	OMA
NV2t001390002.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	PANTHER
NV2t001390003.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	PANTHER
NV2t001393001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001393001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t001393001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t001393001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001393001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001393001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t001396001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t001396001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t001397001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001397001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001400001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400002.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t001400002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001400004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400005.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400007.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400007.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400008.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400008.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400009.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400009.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400010.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400010.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400011.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400011.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400012.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400012.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400013.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400013.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400014.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001400014.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001400014.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t001400014.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t001401001.1	biological_process	GO:0016260	selenocysteine biosynthetic process	"The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t001401001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001401001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001403001.1	cellular_component	GO:1990072	TRAPPIII protein complex	"A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257]	PANTHER
NV2t001404001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t001404001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001404001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001407001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t001407001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t001407001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t001407001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001407001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t001407001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t001407001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t001407001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001407001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001407002.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t001407002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001408001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	InterPro
NV2t001408001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t001408001.1	molecular_function	GO:0004175	endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]	OMA
NV2t001410001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t001410001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t001411001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001411001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t001411001.1	molecular_function	GO:0045134	UDP phosphatase activity	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]	PANTHER
NV2t001413001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t001413001.1	molecular_function	GO:0042134	rRNA primary transcript binding	"Binding to an unprocessed ribosomal RNA transcript." [GOC:jl]	InterPro
NV2t001413002.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t001413002.1	molecular_function	GO:0042134	rRNA primary transcript binding	"Binding to an unprocessed ribosomal RNA transcript." [GOC:jl]	InterPro
NV2t001413003.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t001413003.1	molecular_function	GO:0042134	rRNA primary transcript binding	"Binding to an unprocessed ribosomal RNA transcript." [GOC:jl]	InterPro
NV2t001413004.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t001413004.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t001413004.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001413004.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t001413004.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t001413004.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t001413004.1	molecular_function	GO:0042134	rRNA primary transcript binding	"Binding to an unprocessed ribosomal RNA transcript." [GOC:jl]	InterPro
NV2t001414001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t001414001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	InterPro
NV2t001414001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	PANTHER
NV2t001414001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t001414001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t001414001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t001414001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t001414001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t001414001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t001414001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001414001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t001414001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001414001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001414002.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	PANTHER
NV2t001415001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t001415002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001415002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t001415002.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t001415002.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t001415002.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t001415002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t001415002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t001417001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001419001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t001419001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001419001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001419001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001424001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t001424001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t001424001.1	biological_process	GO:0044057	regulation of system process	"Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl]	OMA
NV2t001424001.1	biological_process	GO:0070129	regulation of mitochondrial translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]	OMA
NV2t001424001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t001424001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t001424001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t001424001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t001424001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001424001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001425001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	InterPro
NV2t001425001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t001426001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t001426001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001426001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001426001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001426002.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t001426002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001426002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001426002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001426003.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t001426003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001426004.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t001426004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001426005.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t001426005.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001426005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001426005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001426006.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t001426006.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001426006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001426007.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t001426007.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001426008.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t001426008.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001426008.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001426008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001428001.1	biological_process	GO:0071076	RNA 3' uridylation	"The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule." [GOC:vw, PMID:19430462]	PANTHER
NV2t001428001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001428001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t001430001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001430001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001431001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t001431001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t001431001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	PANTHER
NV2t001431001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t001431001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001431001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001431001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001432001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t001432001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t001439001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t001439001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001439001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001442001.1	biological_process	GO:0006308	DNA catabolic process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t001442001.1	biological_process	GO:0006308	DNA catabolic process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t001442001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001443001.1	biological_process	GO:0019805	quinolinate biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]	InterPro
NV2t001443001.1	biological_process	GO:0070189	kynurenine metabolic process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]	PANTHER
NV2t001443001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t001444001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001445001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001445001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001445001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001445001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t001445001.1	molecular_function	GO:0015294	solute:monoatomic cation symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai]	OMA
NV2t001449001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001449002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001450001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t001450001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t001450001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t001450001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t001450001.1	biological_process	GO:0051701	biological process involved in interaction with host	"An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]	OMA
NV2t001450001.1	cellular_component	GO:0000347	THO complex	"The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]	OMA
NV2t001450001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t001450001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001451001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001451002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001451003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001451004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001451005.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001453001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	InterPro
NV2t001453001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t001453001.1	biological_process	GO:0006104	succinyl-CoA metabolic process	"The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai]	InterPro
NV2t001453001.1	biological_process	GO:0006637	acyl-CoA metabolic process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]	OMA
NV2t001453001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001453001.1	cellular_component	GO:0042709	succinate-CoA ligase complex	"A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [GOC:jl, PMID:10671455]	PANTHER
NV2t001453001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t001453001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001453001.1	molecular_function	GO:0004774	succinate-CoA ligase activity	"Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [GOC:ai]	OMA
NV2t001453001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001453001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001453001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001454001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t001454001.1	biological_process	GO:0015672	inorganic cation transmembrane transport	"A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t001454001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t001454001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t001456001.1	biological_process	GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	"The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]	InterPro
NV2t001456001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t001456001.1	molecular_function	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	"Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001457001.1	biological_process	GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	"The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]	InterPro
NV2t001457001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t001457001.1	molecular_function	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	"Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001460001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t001461001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t001461001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t001461001.1	biological_process	GO:0019556	histidine catabolic process to glutamate and formamide	"The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators]	InterPro
NV2t001461001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001461001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001461001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t001461001.1	molecular_function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	OMA
NV2t001461001.1	molecular_function	GO:0050480	imidazolonepropionase activity	"Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H2O = N-formimidoyl-L-glutamate + H+." [EC:3.5.2.7, RHEA:23660]	PANTHER
NV2t001464001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t001464001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001464001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001464001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t001466001.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t001466001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001468001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	InterPro
NV2t001468001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	OMA
NV2t001468001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001469001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t001469001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t001469001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001469001.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t001469001.1	cellular_component	GO:0034719	SMN-Sm protein complex	"A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408]	OMA
NV2t001469001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t001469001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t001469001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001469001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001469001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001470001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t001470001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t001470001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t001470001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001470001.1	cellular_component	GO:0019897	extrinsic component of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]	OMA
NV2t001470001.1	molecular_function	GO:0030742	GTP-dependent protein binding	"Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state." [GOC:go_curators, GOC:krc]	OMA
NV2t001470001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t001470001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t001470001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001471001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	PANTHER
NV2t001471001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001471001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001472001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t001472001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t001472001.1	biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t001472001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t001472001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t001472001.1	molecular_function	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]	OMA
NV2t001473001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	InterPro
NV2t001473001.1	cellular_component	GO:0071021	U2-type post-spliceosomal complex	"A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]	PANTHER
NV2t001474001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001474001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t001474001.1	molecular_function	GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	"Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA." [PMID:16751265]	PANTHER
NV2t001477001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t001477001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t001477001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t001477001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t001477001.1	molecular_function	GO:0004879	nuclear receptor activity	"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]	OMA
NV2t001477001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001477001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001477001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t001481001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t001498001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001503001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t001505001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t001509001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t001514001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001515001.1	biological_process	GO:0006544	glycine metabolic process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]	InterPro
NV2t001515001.1	biological_process	GO:0006544	glycine metabolic process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]	OMA
NV2t001515001.1	biological_process	GO:0006546	glycine catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]	InterPro
NV2t001515001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t001515001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t001515001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t001515001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001515001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t001515001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001515001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t001515001.1	molecular_function	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t001515001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	OMA
NV2t001515001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t001515001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t001515001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t001523001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	InterPro
NV2t001523001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	OMA
NV2t001523001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t001523001.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	OMA
NV2t001523001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001523001.1	cellular_component	GO:0042720	mitochondrial inner membrane peptidase complex	"Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]	PANTHER
NV2t001523001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t001523001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t001523001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t001530001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001530001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001530001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t001543001.1	cellular_component	GO:0042720	mitochondrial inner membrane peptidase complex	"Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]	PANTHER
NV2t001543002.1	cellular_component	GO:0042720	mitochondrial inner membrane peptidase complex	"Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]	PANTHER
NV2t001543003.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	InterPro
NV2t001543003.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	OMA
NV2t001543003.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t001543003.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	OMA
NV2t001543003.1	cellular_component	GO:0042720	mitochondrial inner membrane peptidase complex	"Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]	PANTHER
NV2t001543003.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t001543003.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t001543003.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t001544001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t001544001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t001544001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t001544002.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t001544002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t001544002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t001547001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t001548001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t001549001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001549001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001549001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001549001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001549001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001565001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t001565001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001565001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001565001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t001565002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001565002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001572001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001572001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001574001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t001574001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001574001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001574001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t001574001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001574001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001587001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001588001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t001588001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t001588001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t001588001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t001588001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t001588001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t001588001.1	molecular_function	GO:0003727	single-stranded RNA binding	"Binding to single-stranded RNA." [GOC:jl]	OMA
NV2t001588001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t001588001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t001588001.1	molecular_function	GO:0034458	3'-5' RNA helicase activity	"Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis." [GOC:jp]	OMA
NV2t001588002.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t001588002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t001588002.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t001588003.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t001588003.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t001588003.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t001589001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	InterPro
NV2t001589001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t001589001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t001589001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t001589001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t001589001.1	cellular_component	GO:0072487	MSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]	PANTHER
NV2t001589001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t001589001.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	OMA
NV2t001589001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t001590001.1	biological_process	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t001590001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001590001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t001590001.1	molecular_function	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t001590001.1	molecular_function	GO:0047545	2-hydroxyglutarate dehydrogenase activity	"Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]	PANTHER
NV2t001591001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t001591001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t001591001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001591001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001592001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t001594001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t001594001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t001594001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t001594001.1	biological_process	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	OMA
NV2t001594001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t001594001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t001594001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	PANTHER
NV2t001594001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t001594001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001594001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001595001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001597001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t001597001.1	biological_process	GO:0061780	mitotic cohesin loading	"The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle." [GOC:dph, GOC:vw]	OMA
NV2t001597001.1	biological_process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	"The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]	PANTHER
NV2t001597001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t001597002.1	biological_process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	"The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]	PANTHER
NV2t001597003.1	biological_process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	"The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]	PANTHER
NV2t001597004.1	biological_process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	"The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]	PANTHER
NV2t001600001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001600001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001600001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001600002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001600002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t001600002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t001600002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001600002.1	molecular_function	GO:0004697	diacylglycerol-dependent serine/threonine kinase activity	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]	OMA
NV2t001600002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001600002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001600003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001600003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001600003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001604001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001605001.1	molecular_function	GO:0009374	biotin binding	"Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001605001.1	molecular_function	GO:0009374	biotin binding	"Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t001605002.1	molecular_function	GO:0009374	biotin binding	"Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001605002.1	molecular_function	GO:0009374	biotin binding	"Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t001607001.1	molecular_function	GO:0009374	biotin binding	"Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001607001.1	molecular_function	GO:0009374	biotin binding	"Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t001607001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t001607001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t001607001.1	molecular_function	GO:0033293	monocarboxylic acid binding	"Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah]	OMA
NV2t001607001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t001607001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t001607001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t001608001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t001608001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t001608001.1	biological_process	GO:0097428	protein maturation by iron-sulfur cluster transfer	"The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]	PANTHER
NV2t001608001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001608001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t001608001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t001610001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t001610002.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t001610002.1	biological_process	GO:0007608	sensory perception of smell	"The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai]	OMA
NV2t001610002.1	biological_process	GO:0045494	photoreceptor cell maintenance	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]	InterPro
NV2t001610002.1	biological_process	GO:0045494	photoreceptor cell maintenance	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]	OMA
NV2t001610003.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t001612001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001612001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t001613001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001613001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001613001.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t001613002.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t001613002.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t001613002.1	cellular_component	GO:0030132	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	OMA
NV2t001613002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001613002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001613002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001613002.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t001613003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001613003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001613003.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t001614001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	InterPro
NV2t001614001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t001615001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t001615001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t001615001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	OMA
NV2t001615001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t001615001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001615001.1	molecular_function	GO:0008195	phosphatidate phosphatase activity	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [GOC:pr, PMID:25814022, RHEA:27429]	OMA
NV2t001615001.1	molecular_function	GO:0042577	lipid phosphatase activity	"Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]	OMA
NV2t001617001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t001617001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001617001.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	OMA
NV2t001617001.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	PANTHER
NV2t001618001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001618001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001618001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001621001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t001621001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001621001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t001626001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t001628001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001629001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001629001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t001629001.1	molecular_function	GO:0008172	S-methyltransferase activity	"Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai]	OMA
NV2t001629001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001629001.1	molecular_function	GO:0047150	betaine-homocysteine S-methyltransferase activity	"Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22336]	PANTHER
NV2t001629002.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001629002.1	molecular_function	GO:0047150	betaine-homocysteine S-methyltransferase activity	"Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22336]	PANTHER
NV2t001632002.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001632002.1	molecular_function	GO:0047150	betaine-homocysteine S-methyltransferase activity	"Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22336]	PANTHER
NV2t001632003.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001632003.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t001632003.1	molecular_function	GO:0008172	S-methyltransferase activity	"Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai]	OMA
NV2t001632003.1	molecular_function	GO:0047150	betaine-homocysteine S-methyltransferase activity	"Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22336]	PANTHER
NV2t001634001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001639001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t001639001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t001639001.1	biological_process	GO:2000786	positive regulation of autophagosome assembly	"Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t001639001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t001639001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t001639001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t001639001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001639001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001639002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001639003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001639004.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001639005.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001639006.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001640001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001640001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001640001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001640002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001640002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001644001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001644001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001644001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001644001.1	molecular_function	GO:0015276	ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001645001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001645001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001645001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001645002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001645002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001645002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001645003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001645003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001645003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001645004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001645004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001645004.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001645005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001645005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001645005.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001645006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001645006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001645006.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001647001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001647001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t001647001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t001647001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t001647001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t001647001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t001647001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001647001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001647001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001647001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001648001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t001648001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	InterPro
NV2t001648001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t001648001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t001648001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001648001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001648001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001649001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001649001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t001649001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t001653001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t001653001.1	biological_process	GO:0038203	TORC2 signaling	"A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]	OMA
NV2t001653001.1	biological_process	GO:0038203	TORC2 signaling	"A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]	PANTHER
NV2t001653001.1	biological_process	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t001653001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001653001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001653001.1	cellular_component	GO:0031932	TORC2 complex	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t001653001.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t001653001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t001654001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001654001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t001654001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t001654001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t001654001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	OMA
NV2t001654001.1	biological_process	GO:0046686	response to cadmium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai]	OMA
NV2t001654001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t001654001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t001654001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t001654001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001654001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t001654001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t001654001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t001654001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001655001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t001655001.1	biological_process	GO:0007129	homologous chromosome pairing at meiosis	"The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]	OMA
NV2t001655001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t001655001.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t001655001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001655001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t001655001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001655001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t001655001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t001655001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t001655001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t001656001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t001656001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001657001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t001657001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t001657001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t001657001.1	biological_process	GO:0032091	negative regulation of protein binding	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t001657001.1	biological_process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t001657001.1	biological_process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t001657001.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t001657001.1	cellular_component	GO:0005674	transcription factor TFIIF complex	"A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]	OMA
NV2t001657001.1	molecular_function	GO:0001096	TFIIF-class transcription factor complex binding	"Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867]	OMA
NV2t001657001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t001657001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t001657001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t001657001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	OMA
NV2t001657001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t001657001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t001657001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	OMA
NV2t001658001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001658001.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	InterPro
NV2t001658001.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	OMA
NV2t001659001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	InterPro
NV2t001659001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t001659001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t001659001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t001659001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t001659002.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	InterPro
NV2t001660001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t001660001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t001660001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t001660001.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	OMA
NV2t001660001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001661001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001661001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001661001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001661001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t001663001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001667001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t001667001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t001667001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t001667001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t001667001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t001671002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001671002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001671003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001671003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001672001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t001672001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001672001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t001676001.1	biological_process	GO:0000423	mitophagy	"The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367]	InterPro
NV2t001676001.1	biological_process	GO:0000423	mitophagy	"The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367]	OMA
NV2t001676001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001678001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t001678001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001679001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001679001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001679001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001679001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001680001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t001680001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t001680001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t001680001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001680001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001680001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t001683001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t001683001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	OMA
NV2t001683001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t001683001.1	cellular_component	GO:0034518	RNA cap binding complex	"A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation." [GOC:mah]	OMA
NV2t001683001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t001683001.1	molecular_function	GO:0000340	RNA 7-methylguanosine cap binding	"Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]	OMA
NV2t001683001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t001684001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001684001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001685001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t001685001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t001685001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t001685001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t001685001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t001685001.1	biological_process	GO:0090322	regulation of superoxide metabolic process	"Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:tb]	OMA
NV2t001685001.1	biological_process	GO:2000378	negative regulation of reactive oxygen species metabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]	OMA
NV2t001685001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t001685001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001685001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t001685001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001685001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t001686001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t001686001.1	molecular_function	GO:0003968	RNA-dependent RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]	InterPro
NV2t001686001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001689001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t001689001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t001689001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t001689001.1	molecular_function	GO:0046527	glucosyltransferase activity	"Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	OMA
NV2t001689001.1	molecular_function	GO:0106073	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	"Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol." [GOC:ha, PMID:9597543]	InterPro
NV2t001689001.1	molecular_function	GO:0106073	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	"Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol." [GOC:ha, PMID:9597543]	PANTHER
NV2t001692001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t001692002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t001692003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t001693001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t001693001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t001694001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t001694001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t001694001.1	biological_process	GO:0019985	translesion synthesis	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]	OMA
NV2t001694001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t001694001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t001694001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001694001.1	cellular_component	GO:0097505	Rad6-Rad18 complex	"A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity." [GOC:jd, PMID:9287349]	PANTHER
NV2t001694001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t001694001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001694001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001694001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t001694001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t001694001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t001695001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001695001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t001695001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t001696001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t001696001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001696001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001696001.1	molecular_function	GO:0005539	glycosaminoglycan binding	"Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t001696001.1	molecular_function	GO:0030228	lipoprotein particle receptor activity	"Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:bf, GOC:mah, PMID:12827279]	OMA
NV2t001696001.1	molecular_function	GO:0071813	lipoprotein particle binding	"Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:BHF, GOC:mah]	OMA
NV2t001698001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t001698001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t001698001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t001698001.1	biological_process	GO:0008064	regulation of actin polymerization or depolymerization	"Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t001698001.1	biological_process	GO:0010592	positive regulation of lamellipodium assembly	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]	OMA
NV2t001698001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t001698001.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	OMA
NV2t001698001.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	PANTHER
NV2t001698001.1	biological_process	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	"Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476]	OMA
NV2t001698001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t001698001.1	cellular_component	GO:0031209	SCAR complex	"A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101]	OMA
NV2t001698001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t001698001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t001698001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t001703001.1	biological_process	GO:0070292	N-acylphosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group." [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693]	PANTHER
NV2t001703001.1	molecular_function	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	"Catalysis of the reaction: H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine (NAE) + H+." [PMID:14634025, PMID:15878693, RHEA:33159]	InterPro
NV2t001706001.1	biological_process	GO:0070292	N-acylphosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group." [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693]	PANTHER
NV2t001706002.1	biological_process	GO:0070292	N-acylphosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group." [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693]	PANTHER
NV2t001707001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	InterPro
NV2t001707001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t001707001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t001707001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001707001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001707001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t001707001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	InterPro
NV2t001707001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	PANTHER
NV2t001707001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001708001.1	biological_process	GO:0006627	protein processing involved in protein targeting to mitochondrion	"The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]	PANTHER
NV2t001708001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001708002.1	biological_process	GO:0006627	protein processing involved in protein targeting to mitochondrion	"The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]	PANTHER
NV2t001708002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001708003.1	biological_process	GO:0006627	protein processing involved in protein targeting to mitochondrion	"The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]	PANTHER
NV2t001708003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001708004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001708004.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t001708004.1	biological_process	GO:0006627	protein processing involved in protein targeting to mitochondrion	"The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]	PANTHER
NV2t001708004.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	OMA
NV2t001708004.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t001708004.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t001708004.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t001708004.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001708004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001708004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001709001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t001709001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t001709001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t001709001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t001709001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	PANTHER
NV2t001711001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t001711001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t001711001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t001711001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001711001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001711001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001712001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t001712001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t001712001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001717001.1	molecular_function	GO:0032452	histone demethylase activity	"Catalysis of the removal of a methyl group from a histone." [GOC:mah]	PANTHER
NV2t001719001.1	biological_process	GO:0070831	basement membrane assembly	"The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah]	PANTHER
NV2t001719001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001721002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001722001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t001722001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t001724001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t001724001.1	biological_process	GO:0032042	mitochondrial DNA metabolic process	"The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah]	OMA
NV2t001724001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001724001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001724001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t001724001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001724001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t001724001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t001724001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t001724001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t001725001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t001725001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	OMA
NV2t001725001.1	biological_process	GO:0009303	rRNA transcription	"The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732]	OMA
NV2t001725001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001725001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t001725001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t001725001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t001725001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t001725001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001725001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001727002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001727002.1	molecular_function	GO:1990247	N6-methyladenosine-containing RNA reader activity	"A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]	PANTHER
NV2t001727003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001727003.1	molecular_function	GO:1990247	N6-methyladenosine-containing RNA reader activity	"A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]	PANTHER
NV2t001728001.1	biological_process	GO:0015813	L-glutamate transmembrane transport	"The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	PANTHER
NV2t001728001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001728002.1	biological_process	GO:0015813	L-glutamate transmembrane transport	"The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	PANTHER
NV2t001728002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001728002.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t001729001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t001729001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t001729001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t001729001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t001729001.1	biological_process	GO:0051668	localization within membrane	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai]	OMA
NV2t001729001.1	biological_process	GO:0090114	COPII-coated vesicle budding	"The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t001729001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t001729001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t001729001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t001729001.1	cellular_component	GO:0030120	vesicle coat	"A membrane coat found on a coated vesicle." [GOC:mah]	OMA
NV2t001729001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t001729001.1	cellular_component	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	OMA
NV2t001729001.1	cellular_component	GO:0061700	GATOR2 complex	"A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins." [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700]	OMA
NV2t001729001.1	cellular_component	GO:0098687	chromosomal region	"Any subdivision of a chromosome along its length." [GOC:dos]	OMA
NV2t001729001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t001729001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001729001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001729002.1	biological_process	GO:0090114	COPII-coated vesicle budding	"The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t001729002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001731001.1	cellular_component	GO:0032426	stereocilium tip	"A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation." [GOC:ecd, GOC:krc, PMID:17021180, PMID:27565685]	PANTHER
NV2t001731001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001732001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t001732001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t001736001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001736001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001736001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001737001.1	biological_process	GO:0042791	5S class rRNA transcription by RNA polymerase III	"The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter." [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659]	PANTHER
NV2t001738001.1	biological_process	GO:0001837	epithelial to mesenchymal transition	"A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]	OMA
NV2t001738001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t001738001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t001738001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t001738001.1	biological_process	GO:0006903	vesicle targeting	"The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]	OMA
NV2t001738001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t001738001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t001738001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t001738001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t001738001.1	biological_process	GO:0048863	stem cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]	OMA
NV2t001738001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t001738001.1	cellular_component	GO:0030120	vesicle coat	"A membrane coat found on a coated vesicle." [GOC:mah]	OMA
NV2t001738001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t001738001.1	cellular_component	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	OMA
NV2t001738001.1	cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]	OMA
NV2t001738001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001739001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t001739001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	OMA
NV2t001739001.1	biological_process	GO:0045046	protein import into peroxisome membrane	"The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502]	InterPro
NV2t001739001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t001739001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t001739001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t001739001.1	molecular_function	GO:0051117	ATPase binding	"Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai]	PANTHER
NV2t001740001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001740001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t001740001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001740001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t001740001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t001740001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	InterPro
NV2t001740001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t001741001.1	biological_process	GO:2000767	positive regulation of cytoplasmic translation	"Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	OMA
NV2t001741001.1	biological_process	GO:2000767	positive regulation of cytoplasmic translation	"Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	PANTHER
NV2t001741001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001741001.1	molecular_function	GO:0003727	single-stranded RNA binding	"Binding to single-stranded RNA." [GOC:jl]	OMA
NV2t001741001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t001741001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001741001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001741001.1	molecular_function	GO:0045182	translation regulator activity	"Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]	OMA
NV2t001743001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t001743001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001743001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t001743001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t001743001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t001743001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t001743001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t001743002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t001743002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001743002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t001744001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001747001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t001747001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t001747001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001747001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001747001.1	molecular_function	GO:0004300	enoyl-CoA hydratase activity	"Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17]	OMA
NV2t001748001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001748001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001748001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t001748001.1	biological_process	GO:0043171	peptide catabolic process	"The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl]	PANTHER
NV2t001748001.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t001748001.1	biological_process	GO:0046456	icosanoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732]	OMA
NV2t001748001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t001748001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001748001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001748001.1	molecular_function	GO:0004301	epoxide hydrolase activity	"Catalysis of the reaction: an epoxide + H2O = an ethanediol." [EC:3.3.2.10]	OMA
NV2t001748001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001748001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001748001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t001750001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	InterPro
NV2t001750001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t001751001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t001751001.1	biological_process	GO:0030111	regulation of Wnt signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t001751001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	OMA
NV2t001751001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t001751001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t001751001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001751001.1	molecular_function	GO:0008195	phosphatidate phosphatase activity	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [GOC:pr, PMID:25814022, RHEA:27429]	OMA
NV2t001751001.1	molecular_function	GO:0042577	lipid phosphatase activity	"Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]	OMA
NV2t001752001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t001752001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t001752001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	OMA
NV2t001752001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t001752001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001752001.1	molecular_function	GO:0008195	phosphatidate phosphatase activity	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [GOC:pr, PMID:25814022, RHEA:27429]	OMA
NV2t001752001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t001752001.1	molecular_function	GO:0042577	lipid phosphatase activity	"Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]	OMA
NV2t001753001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t001753001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t001753001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	OMA
NV2t001753001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t001753001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001753001.1	molecular_function	GO:0008195	phosphatidate phosphatase activity	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [GOC:pr, PMID:25814022, RHEA:27429]	OMA
NV2t001753001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t001753001.1	molecular_function	GO:0042577	lipid phosphatase activity	"Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]	OMA
NV2t001754001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t001754002.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t001754003.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t001754004.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t001755001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t001755002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t001755002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t001755003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t001756001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001756001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001757001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001758001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	OMA
NV2t001758001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001758001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t001758001.1	biological_process	GO:1990547	mitochondrial phosphate ion transmembrane transport	"The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9099701]	InterPro
NV2t001758001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t001758001.1	molecular_function	GO:0005315	phosphate transmembrane transporter activity	"Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]	OMA
NV2t001759001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t001759001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t001759001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t001759001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t001759001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t001759001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t001759001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t001759002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t001759002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t001761001.1	biological_process	GO:0000380	alternative mRNA splicing, via spliceosome	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]	OMA
NV2t001761001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001761001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t001761001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001761001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t001761001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	PANTHER
NV2t001762001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t001762001.1	biological_process	GO:0006812	monoatomic cation transport	"The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t001762001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t001762001.1	biological_process	GO:0032732	positive regulation of interleukin-1 production	"Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah]	InterPro
NV2t001762001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t001762001.1	molecular_function	GO:0015267	channel activity	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001764001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001764001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t001765001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t001766001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001766001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001766001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001766001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001766001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001767001.1	biological_process	GO:0070935	3'-UTR-mediated mRNA stabilization	"An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303]	PANTHER
NV2t001767001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001767001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001767002.1	biological_process	GO:0070935	3'-UTR-mediated mRNA stabilization	"An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303]	PANTHER
NV2t001767002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001767002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001768001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001768001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001768002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001768002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t001768002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001768002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001768002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001768002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t001768002.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t001768002.1	cellular_component	GO:0043197	dendritic spine	"A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]	OMA
NV2t001768002.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t001768002.1	molecular_function	GO:0005250	A-type (transient outward) potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340]	OMA
NV2t001768002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001769001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t001770001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t001770001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t001770001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001770002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t001770002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t001770002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001770003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t001770003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t001770003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001770004.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t001770004.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t001770004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001771001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001771001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001771001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t001771002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t001777001.1	cellular_component	GO:0071942	XPC complex	"A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2." [PMID:11279143, PMID:15964821, PMID:19941824]	PANTHER
NV2t001777001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t001778001.1	biological_process	GO:0000070	mitotic sister chromatid segregation	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]	OMA
NV2t001778001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	InterPro
NV2t001778001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	OMA
NV2t001778001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001779001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001779001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001783001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001783001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001783001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001783001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001783002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001783002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001783002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001783002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001783003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001783003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001783003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001783003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001783004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001783004.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001783004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001783004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001783005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001783005.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001783005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001783005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001783006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001783006.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001783006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001783006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001785001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t001785001.1	biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t001785002.1	biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t001787001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001787001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t001787001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001787001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t001787001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t001787001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001787001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001787002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001787003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001787003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001787003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001788001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001788001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t001789001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t001789001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t001790001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001793001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001793001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t001793001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001793001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t001793001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001793001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001793001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001793001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001797001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t001797001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t001797001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001797001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t001797001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	OMA
NV2t001799001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001800001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t001800001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001802001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t001802001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t001802001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t001802001.1	molecular_function	GO:0004896	cytokine receptor activity	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]	OMA
NV2t001802001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001802001.1	molecular_function	GO:0019955	cytokine binding	"Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]	OMA
NV2t001803001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001803001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001804001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t001804001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001806001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t001806001.1	biological_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t001806001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t001806001.1	biological_process	GO:2001267	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t001806001.1	biological_process	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t001807001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001807001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t001807002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001807002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001807002.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t001807002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t001808001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t001808001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001808001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001808001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t001808001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001808001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001808002.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t001808002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t001808002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001808002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001811001.1	biological_process	GO:0006206	pyrimidine nucleobase metabolic process	"The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	OMA
NV2t001811001.1	biological_process	GO:0044270	obsolete cellular nitrogen compound catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t001811001.1	biological_process	GO:0046700	obsolete heterocycle catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]	OMA
NV2t001811001.1	biological_process	GO:1901361	organic cyclic compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t001811001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t001811001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001811001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t001811001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t001811001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	PANTHER
NV2t001812001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001812001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t001812002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001812002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t001812003.1	biological_process	GO:0006335	DNA replication-dependent chromatin assembly	"The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation." [GOC:mah, PMID:28053344]	OMA
NV2t001812003.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	OMA
NV2t001812003.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t001812003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001812003.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t001812003.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t001812004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001812004.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t001814001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001814001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t001814001.1	biological_process	GO:0010737	protein kinase A signaling	"An intracellular signaling cassette that starts with the activation of protein kinase A (PKA), and ends with the regulation of a downstream cellular process, e.g. transcription. The PKA catalytic subunit (PKA-C) is normally present in a complex with its regulatory subunit, PKA-R. The inhibitory action of PKA-R is released upon cAMP binding, which results in the activation of PKA-C." [PMID:35252178, PMID:36431013]	PANTHER
NV2t001814001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t001814001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001814001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t001814001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001816001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	PANTHER
NV2t001816001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001816001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001816002.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	PANTHER
NV2t001816002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001817001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t001817001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t001817001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t001817001.1	cellular_component	GO:0032045	guanyl-nucleotide exchange factor complex	"A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah]	OMA
NV2t001817001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001817002.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t001817002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001817003.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t001818001.1	biological_process	GO:0046705	CDP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai]	PANTHER
NV2t001818001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t001818002.1	biological_process	GO:0046705	CDP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai]	PANTHER
NV2t001818002.1	molecular_function	GO:0009041	UMP/dUMP kinase activity	"Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators]	InterPro
NV2t001818002.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t001819001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001819001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001820001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t001820001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t001820001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001820001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t001820001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t001820001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t001820001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t001820002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t001820002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t001820002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001820002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t001820002.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t001820002.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t001820002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t001820003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t001820003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t001820003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001820003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t001820003.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t001820003.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t001820003.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t001821001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t001821001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001821002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t001821002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001821002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t001821002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t001821002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001822001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001822002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001822003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001822004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001822005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001823001.1	biological_process	GO:0000132	establishment of mitotic spindle orientation	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]	OMA
NV2t001823001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t001823001.1	molecular_function	GO:0001965	G-protein alpha-subunit binding	"Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]	OMA
NV2t001823001.1	molecular_function	GO:0005092	GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]	OMA
NV2t001823001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001824001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001824001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t001824001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t001824001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001824002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001824002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001824002.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t001824003.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t001824004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001824004.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t001824004.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t001824004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001824004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001825001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t001825002.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	PANTHER
NV2t001825002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t001825003.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	PANTHER
NV2t001825003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t001828001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t001828001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001828001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t001828001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t001829001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	InterPro
NV2t001829001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001829002.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	InterPro
NV2t001829002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001830001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001830001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001830001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001830001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t001830001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001830001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001830002.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001830002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001830002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001830002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001831001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001831001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001831001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001831001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001831002.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001831002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001831002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001831002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001831003.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001831003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001831003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001831003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001831004.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001831004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001831004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001831004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001831005.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001831005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001831005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001831005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001831006.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001831006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001831006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001831006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001831007.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t001831007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001831007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001831007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001832001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001832002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001832003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001833001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t001833001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t001833001.1	biological_process	GO:0042797	tRNA transcription by RNA polymerase III	"The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t001833001.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	OMA
NV2t001833001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001833001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t001833001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t001833002.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t001833002.1	biological_process	GO:0042797	tRNA transcription by RNA polymerase III	"The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t001833003.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t001833003.1	biological_process	GO:0042797	tRNA transcription by RNA polymerase III	"The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t001834001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t001834001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t001834001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t001834001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t001834001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001834001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001834001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t001834001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001834002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t001834002.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t001834002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001834003.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t001834003.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t001834003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001835001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t001836001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t001838001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001839001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t001839001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t001839001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t001839001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t001839001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t001839001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001839001.1	molecular_function	GO:0004563	beta-N-acetylhexosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]	OMA
NV2t001840001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001840001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	OMA
NV2t001840001.1	molecular_function	GO:0047372	acylglycerol lipase activity	"Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]	PANTHER
NV2t001840001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t001841001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	InterPro
NV2t001841001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t001845001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001845001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001845001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001845001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001845001.1	molecular_function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis]	OMA
NV2t001845002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t001845002.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t001847001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t001847001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t001848001.1	biological_process	GO:0002090	regulation of receptor internalization	"Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]	OMA
NV2t001848001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t001848001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t001848001.1	biological_process	GO:0031532	obsolete actin cytoskeleton reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]	OMA
NV2t001848001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t001848001.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t001848001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001848001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001848001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t001848001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001848001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t001849001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t001849001.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	PANTHER
NV2t001849001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t001849001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t001849001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t001850001.1	biological_process	GO:0002084	protein depalmitoylation	"The removal of palymitoyl groups from a lipoprotein." [GOC:hjd]	OMA
NV2t001850001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001850001.1	molecular_function	GO:0008474	palmitoyl-(protein) hydrolase activity	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]	OMA
NV2t001850001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001850001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t001850001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	PANTHER
NV2t001854001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t001854001.1	biological_process	GO:0061355	Wnt protein secretion	"The controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]	PANTHER
NV2t001854001.1	molecular_function	GO:0017147	Wnt-protein binding	"Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]	OMA
NV2t001854002.1	biological_process	GO:0061355	Wnt protein secretion	"The controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]	PANTHER
NV2t001856001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t001857001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t001857001.1	cellular_component	GO:0071014	post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]	PANTHER
NV2t001859001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t001859001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001859001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t001859001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t001859001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t001860001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t001860001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t001860001.1	molecular_function	GO:0045134	UDP phosphatase activity	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]	PANTHER
NV2t001862001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t001862001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t001863001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001863001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001863001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t001863002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001863002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001863002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t001864001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t001864001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001864001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t001864001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t001864001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t001865001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	PANTHER
NV2t001866001.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	InterPro
NV2t001866001.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	OMA
NV2t001866001.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	OMA
NV2t001866001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001867001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t001868001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001870001.1	biological_process	GO:0000097	sulfur amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]	OMA
NV2t001870001.1	biological_process	GO:0009070	serine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t001870001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001870001.1	molecular_function	GO:0016846	carbon-sulfur lyase activity	"Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]	OMA
NV2t001870001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t001870001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t001873001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t001873001.1	molecular_function	GO:0042281	dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	"Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [GOC:al, MetaCyc:RXN-5470]	PANTHER
NV2t001878001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t001878001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	PANTHER
NV2t001878001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t001878001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t001878001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001878002.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	PANTHER
NV2t001878002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t001878002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001879001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t001879001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t001879001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t001879001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001879001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t001879001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t001880001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001881001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	OMA
NV2t001881001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	PANTHER
NV2t001881001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t001881001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	OMA
NV2t001881001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t001881001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001881001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t001881001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001881002.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	PANTHER
NV2t001881002.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t001882001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001882001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t001882001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t001882001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001882001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t001882001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001882001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001885001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001885001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	PANTHER
NV2t001885002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001885002.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	PANTHER
NV2t001885003.1	biological_process	GO:2000694	regulation of phragmoplast microtubule organization	"Any process that modulates the frequency, rate or extent of phragmoplast microtubule organization." [GOC:obol]	PANTHER
NV2t001885004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001885004.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	PANTHER
NV2t001885005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001885005.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	PANTHER
NV2t001886001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t001886001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t001886001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t001889001.1	biological_process	GO:0006865	amino acid transport	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t001889001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001889001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001889001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t001889001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001891001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001891001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001891001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001891002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t001891002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t001891002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t001893001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t001893001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	OMA
NV2t001893001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t001893001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t001893001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t001893001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t001893001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t001895001.1	biological_process	GO:0006000	fructose metabolic process	"The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732]	InterPro
NV2t001895001.1	biological_process	GO:0006003	fructose 2,6-bisphosphate metabolic process	"The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732]	InterPro
NV2t001895001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t001895001.1	biological_process	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	OMA
NV2t001895001.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t001895001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t001895001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001895001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001895001.1	molecular_function	GO:0008443	phosphofructokinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule." [GOC:jl]	OMA
NV2t001897001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t001897001.1	biological_process	GO:0034332	adherens junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t001897001.1	biological_process	GO:0035329	hippo signaling	"An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation." [PMID:17318211, PMID:18328423, PMID:36347846]	OMA
NV2t001897001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001897001.1	cellular_component	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	OMA
NV2t001897001.1	cellular_component	GO:0016327	apicolateral plasma membrane	"The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]	OMA
NV2t001897001.1	cellular_component	GO:0043195	terminal bouton	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]	OMA
NV2t001897001.1	cellular_component	GO:0097482	muscle cell postsynaptic specialization	"A postsynaptic specialization that is part of a neuromuscular junction." [GOC:pr]	OMA
NV2t001897001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001897001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t001898001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001898001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001898001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001899001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t001899001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t001899001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t001899001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t001899001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t001899001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t001899001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t001899001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t001900001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t001900001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t001900001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t001900001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t001900001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t001900002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t001901001.1	cellular_component	GO:0008622	epsilon DNA polymerase complex	"A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]	PANTHER
NV2t001901001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t001901001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t001902001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001902001.1	molecular_function	GO:0072345	NAADP-sensitive calcium-release channel activity	"Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts." [PMID:19387438, PMID:19557428]	PANTHER
NV2t001903001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001903001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t001903001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t001903002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001903002.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t001903002.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t001903003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001903003.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t001903003.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t001903004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001903004.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t001903004.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t001903005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t001903005.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t001903005.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t001903005.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001903005.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t001903005.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t001903005.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t001904001.1	molecular_function	GO:0072345	NAADP-sensitive calcium-release channel activity	"Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts." [PMID:19387438, PMID:19557428]	PANTHER
NV2t001904002.1	molecular_function	GO:0005261	monoatomic cation channel activity	"Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t001904002.1	molecular_function	GO:0072345	NAADP-sensitive calcium-release channel activity	"Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts." [PMID:19387438, PMID:19557428]	PANTHER
NV2t001905001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t001905001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	OMA
NV2t001905001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001905001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t001905001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t001905001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t001905001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t001905001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t001905001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t001905001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	InterPro
NV2t001905001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t001905001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	PANTHER
NV2t001905001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	OMA
NV2t001907001.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t001907001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001907001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001907001.1	molecular_function	GO:0004430	1-phosphatidylinositol 4-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+." [EC:2.7.1.67, RHEA:19877]	OMA
NV2t001907001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t001907001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	PANTHER
NV2t001909001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t001909001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001909001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t001911001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001912001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t001912001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001912001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001914001.1	biological_process	GO:0009142	nucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t001914001.1	biological_process	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t001914001.1	biological_process	GO:0009167	purine ribonucleoside monophosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t001914001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t001914001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t001914001.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	InterPro
NV2t001914001.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	OMA
NV2t001914001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001914001.1	molecular_function	GO:0016776	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	InterPro
NV2t001914001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t001915001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t001915001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t001915001.1	biological_process	GO:0051338	regulation of transferase activity	"Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai]	OMA
NV2t001915001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t001915001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t001915001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001915001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t001915001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t001915001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t001916001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t001916001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t001916001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t001916001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t001916001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t001916001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t001916002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t001916002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t001917001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t001917001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t001918001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t001921001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t001921001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t001921001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t001921001.1	biological_process	GO:0048280	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	PANTHER
NV2t001921001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t001921001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t001921001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001921001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001922001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t001922001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	InterPro
NV2t001922001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t001922001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	PANTHER
NV2t001922002.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t001922002.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	InterPro
NV2t001922002.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	PANTHER
NV2t001922003.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t001922003.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	InterPro
NV2t001922003.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	PANTHER
NV2t001922004.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t001922004.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	InterPro
NV2t001922004.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	PANTHER
NV2t001922005.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t001922005.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	InterPro
NV2t001922005.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	PANTHER
NV2t001922006.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t001922006.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	InterPro
NV2t001922006.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	PANTHER
NV2t001923001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001923001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t001923001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001923001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001923001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t001925001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t001925001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t001925001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t001925001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t001926001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t001926001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t001926001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t001926001.1	cellular_component	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	"A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838]	PANTHER
NV2t001926001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t001926001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t001926001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001928001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	InterPro
NV2t001929001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t001929001.1	biological_process	GO:0034329	cell junction assembly	"A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]	OMA
NV2t001929001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t001929001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	OMA
NV2t001929001.1	cellular_component	GO:0008290	F-actin capping protein complex	"A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560]	OMA
NV2t001929001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t001929001.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	OMA
NV2t001929001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t001929001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t001930001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t001930001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	InterPro
NV2t001930002.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t001930002.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	InterPro
NV2t001930002.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t001931001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t001931001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t001931001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	InterPro
NV2t001931001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t001933001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t001934001.1	biological_process	GO:0042307	positive regulation of protein import into nucleus	"Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl]	OMA
NV2t001934001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t001934001.1	biological_process	GO:1903569	positive regulation of protein localization to ciliary membrane	"Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]	PANTHER
NV2t001934001.1	biological_process	GO:1904377	positive regulation of protein localization to cell periphery	"Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290]	OMA
NV2t001934001.1	biological_process	GO:1905477	positive regulation of protein localization to membrane	"Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	OMA
NV2t001934001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t001934001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t001934001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t001934001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t001934001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t001934001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t001934001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t001935001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t001935001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t001935001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t001935001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t001935001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001935001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t001938001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t001938001.1	biological_process	GO:0005980	glycogen catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	InterPro
NV2t001940001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t001940001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001940001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t001940001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t001940001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t001940001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t001941001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001941001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001941001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t001941002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001941002.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t001941003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001941003.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t001941004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001941004.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t001941005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001941005.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t001941006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001941006.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t001942001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001942001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001942001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001943001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001943001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001943001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001943002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001943002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001945001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t001945001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001945001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t001948001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t001948001.1	biological_process	GO:0006285	base-excision repair, AP site formation	"The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194]	InterPro
NV2t001948001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t001948001.1	molecular_function	GO:0004844	uracil DNA N-glycosylase activity	"Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623]	OMA
NV2t001948001.1	molecular_function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	"Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623]	OMA
NV2t001948001.1	molecular_function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	"Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623]	PANTHER
NV2t001951001.1	biological_process	GO:0106217	tRNA C3-cytosine methylation	"The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine." [PMID:28655767]	PANTHER
NV2t001961001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t001961001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t001961001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t001961001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t001961001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001961001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t001961001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001961002.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t001961002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001961002.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001962001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001962001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001962001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t001965001.1	biological_process	GO:0080163	regulation of protein serine/threonine phosphatase activity	"Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]	OMA
NV2t001965001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t001965001.1	cellular_component	GO:0005956	protein kinase CK2 complex	"A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779]	OMA
NV2t001965001.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	InterPro
NV2t001965001.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t001965002.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	InterPro
NV2t001969001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t001969001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t001969001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t001973001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t001973001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t001973001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t001973001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t001973001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t001973001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t001974001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001974001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t001974001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t001979001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t001979001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t001979001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t001985001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t001985001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t001985001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t001986001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001986001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001986001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001986001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001987001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001987001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001987001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001987001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001988001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001988001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001988001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001988002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001988002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001988002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001988003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001988003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001988003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001988003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t001988004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t001988004.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t001988004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t001989002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001989002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001989003.1	biological_process	GO:0006820	monoatomic anion transport	"The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t001989003.1	biological_process	GO:0050801	monoatomic ion homeostasis	"Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t001989003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t001989003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001989003.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t001989003.1	molecular_function	GO:0005452	solute:inorganic anion antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)." [GOC:mah]	OMA
NV2t001990001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t001990001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t001990001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t001990001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001990002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001990003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t001991001.1	cellular_component	GO:0044611	nuclear pore inner ring	"A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t001991001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t001991002.1	cellular_component	GO:0044611	nuclear pore inner ring	"A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t001992001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t001992001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t001992001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t001992001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t001994001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t001995001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001995002.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t001995002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t001995002.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t001995002.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t001995002.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t001996001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t001996001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t001997001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	OMA
NV2t001997001.1	biological_process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	"The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t001997001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t001997001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t001997001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t001997001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t001997001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001997001.1	molecular_function	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t001997002.1	biological_process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	"The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t001997002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001998001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t001998001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t001998001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t001999001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t002003001.1	biological_process	GO:0006542	glutamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	OMA
NV2t002003001.1	biological_process	GO:0006542	glutamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	PANTHER
NV2t002003001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002003001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002003001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002003001.1	molecular_function	GO:0004356	glutamine synthetase activity	"Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate." [RHEA:16169]	OMA
NV2t002005001.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	InterPro
NV2t002005001.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	OMA
NV2t002005001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t002006001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t002006001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002006001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002006001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t002008001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t002008001.1	biological_process	GO:0016476	regulation of embryonic cell shape	"Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]	OMA
NV2t002008001.1	biological_process	GO:0032185	septin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t002008001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t002008001.1	biological_process	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	OMA
NV2t002008001.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t002008001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t002008001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t002008001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t002008001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t002008001.1	cellular_component	GO:0097541	axonemal basal plate	"Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure." [GOC:cilia, PMID:23352055, PMID:4554367]	PANTHER
NV2t002009001.1	biological_process	GO:0048168	regulation of neuronal synaptic plasticity	"A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, PMID:11891290]	PANTHER
NV2t002011001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t002011001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t002011001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t002011001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t002012001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002017001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002018001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002018001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t002020001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t002020001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002023001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002023001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t002023001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002023002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t002023003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002023003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t002023003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002023004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t002023005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002023005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t002023005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002026001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t002026001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002026001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002026001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t002026001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t002026001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t002026001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t002026001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t002026001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t002027001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t002028001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t002029001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t002029001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t002029002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t002029002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t002037001.1	cellular_component	GO:0070776	MOZ/MORF histone acetyltransferase complex	"A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]	PANTHER
NV2t002037001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002037002.1	cellular_component	GO:0070776	MOZ/MORF histone acetyltransferase complex	"A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]	PANTHER
NV2t002037002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002039001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t002039001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t002039001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t002039001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t002039001.1	biological_process	GO:0072384	organelle transport along microtubule	"The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]	OMA
NV2t002039001.1	biological_process	GO:0072384	organelle transport along microtubule	"The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]	PANTHER
NV2t002039001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t002039001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t002039001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t002039001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t002039001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	InterPro
NV2t002039001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	OMA
NV2t002039001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t002039002.1	biological_process	GO:0072384	organelle transport along microtubule	"The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]	PANTHER
NV2t002039002.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t002039002.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	InterPro
NV2t002045001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t002045001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t002045001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t002045001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t002045002.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t002045002.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t002046001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t002046001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002046001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002047001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t002047001.1	biological_process	GO:0000729	DNA double-strand break processing	"The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855]	OMA
NV2t002047001.1	biological_process	GO:0002757	immune response-activating signaling pathway	"The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add]	OMA
NV2t002047001.1	biological_process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]	OMA
NV2t002047001.1	biological_process	GO:0006301	postreplication repair	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh]	OMA
NV2t002047001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t002047001.1	biological_process	GO:0031058	obsolete positive regulation of histone modification	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]	OMA
NV2t002047001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t002047001.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	OMA
NV2t002047001.1	biological_process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	"Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb]	OMA
NV2t002047001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t002047001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t002047001.1	biological_process	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t002047001.1	biological_process	GO:2000781	positive regulation of double-strand break repair	"Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t002047001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t002047001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002047001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002047001.1	cellular_component	GO:0035370	UBC13-UEV1A complex	"A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A)." [GOC:amm, PMID:16129784]	OMA
NV2t002047001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t002047001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t002047001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t002048001.1	biological_process	GO:0006544	glycine metabolic process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]	OMA
NV2t002048001.1	biological_process	GO:0006546	glycine catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]	InterPro
NV2t002048001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t002048001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t002048001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t002048001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002048001.1	molecular_function	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2.-, GOC:mah]	OMA
NV2t002048002.1	biological_process	GO:0006546	glycine catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]	InterPro
NV2t002048002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t002048002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002049001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002049001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t002049001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t002049001.1	biological_process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	"Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]	OMA
NV2t002049001.1	cellular_component	GO:0000118	histone deacetylase complex	"A protein complex that possesses histone deacetylase activity." [GOC:mah]	OMA
NV2t002049001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t002049001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t002049001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t002049001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	PANTHER
NV2t002049001.1	cellular_component	GO:0097346	INO80-type complex	"A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820]	OMA
NV2t002049001.1	molecular_function	GO:0010485	histone H4 acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48]	OMA
NV2t002049001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t002051001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002051001.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t002051001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	OMA
NV2t002051001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t002051001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t002051001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	InterPro
NV2t002053001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t002053001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t002053001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t002053001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t002054001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t002054001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t002054002.1	biological_process	GO:0006044	N-acetylglucosamine metabolic process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]	OMA
NV2t002054002.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	OMA
NV2t002054002.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t002054002.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t002054002.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t002054003.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t002054003.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t002055001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t002055001.1	biological_process	GO:0030177	positive regulation of Wnt signaling pathway	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t002055001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002055001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t002060001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t002060001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t002060001.1	biological_process	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	OMA
NV2t002060001.1	biological_process	GO:0032370	positive regulation of lipid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t002060001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t002060001.1	biological_process	GO:0032388	positive regulation of intracellular transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t002060001.1	biological_process	GO:0042446	hormone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t002060001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t002060001.1	biological_process	GO:1901360	organic cyclic compound metabolic process	"The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]	OMA
NV2t002060001.1	biological_process	GO:1901576	organic substance biosynthetic process	"The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t002060001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t002060001.1	molecular_function	GO:0005548	phospholipid transporter activity	"Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732]	OMA
NV2t002060001.1	molecular_function	GO:0016408	C-acyltransferase activity	"Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]	OMA
NV2t002060001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002060001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t002060001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t002060001.1	molecular_function	GO:0019107	myristoyltransferase activity	"Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t002062001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002064001.1	biological_process	GO:0010324	membrane invagination	"The infolding of a membrane." [GOC:tb]	OMA
NV2t002064001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t002064001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t002064001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	OMA
NV2t002064001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	PANTHER
NV2t002064001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t002064001.1	cellular_component	GO:0005905	clathrin-coated pit	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]	OMA
NV2t002064001.1	cellular_component	GO:0030136	clathrin-coated vesicle	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]	OMA
NV2t002064001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t002064001.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t002064001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t002064002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t002067001.1	biological_process	GO:0045739	positive regulation of DNA repair	"Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators]	OMA
NV2t002067001.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	PANTHER
NV2t002067001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002068001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t002068001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	OMA
NV2t002068001.1	biological_process	GO:0006734	NADH metabolic process	"The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t002068001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t002068001.1	biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]	OMA
NV2t002068001.1	biological_process	GO:0007029	endoplasmic reticulum organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t002068001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t002068001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t002068001.1	biological_process	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t002068001.1	biological_process	GO:0010035	response to inorganic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm]	OMA
NV2t002068001.1	biological_process	GO:0010918	positive regulation of mitochondrial membrane potential	"Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb]	OMA
NV2t002068001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t002068001.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t002068001.1	biological_process	GO:0019985	translesion synthesis	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]	OMA
NV2t002068001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t002068001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t002068001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t002068001.1	biological_process	GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t002068001.1	biological_process	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	OMA
NV2t002068001.1	biological_process	GO:0035617	stress granule disassembly	"The disaggregation of a stress granule into its constituent protein and RNA parts." [GOC:BHF, PMID:19825938]	OMA
NV2t002068001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t002068001.1	biological_process	GO:0045879	negative regulation of smoothened signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t002068001.1	biological_process	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	OMA
NV2t002068001.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	OMA
NV2t002068001.1	biological_process	GO:0071243	cellular response to arsenic-containing substance	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah]	OMA
NV2t002068001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	OMA
NV2t002068001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t002068001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	PANTHER
NV2t002068001.1	biological_process	GO:0106300	protein-DNA covalent cross-linking repair	"The removal of covalent cross-link between DNA and a protein." [PMID:31921408]	OMA
NV2t002068001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t002068001.1	biological_process	GO:1903006	positive regulation of protein K63-linked deubiquitination	"Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]	OMA
NV2t002068001.1	biological_process	GO:1903862	positive regulation of oxidative phosphorylation	"Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:10225962]	OMA
NV2t002068001.1	biological_process	GO:1905634	regulation of protein localization to chromatin	"Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714]	OMA
NV2t002068001.1	biological_process	GO:2001171	positive regulation of ATP biosynthetic process	"Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process." [GOC:obol]	OMA
NV2t002068001.1	cellular_component	GO:0000502	proteasome complex	"A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome]	OMA
NV2t002068001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t002068001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002068001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t002068001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002068001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t002068001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t002068001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t002068001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t002068001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t002068001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t002068001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002068001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t002068001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002068001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t002068001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t002068001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t002068001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t002068001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t002068001.1	molecular_function	GO:0035800	deubiquitinase activator activity	"Binds to and increases the activity of a deubiquitinase." [GOC:sart, ISBN:0120793709]	OMA
NV2t002068001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t002068001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t002068001.1	molecular_function	GO:1990381	ubiquitin-specific protease binding	"Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]	OMA
NV2t002069001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t002069001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t002069001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	OMA
NV2t002069001.1	biological_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t002069001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t002069001.1	biological_process	GO:1902653	secondary alcohol biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t002069001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002069001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t002069001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002069001.1	molecular_function	GO:0003823	antigen binding	"Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell." [GOC:jl, ISBN:0198506732, ISBN:0721662544]	OMA
NV2t002069001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t002069001.1	molecular_function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	PANTHER
NV2t002069001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t002069001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t002069001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t002069001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t002069001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t002071001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t002071001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002071001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002071001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t002071001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t002071001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t002072001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t002072001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t002072001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t002075001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002075001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t002076001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t002076001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t002076001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t002076001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t002076001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t002076001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t002078001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	PANTHER
NV2t002080001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t002080001.1	biological_process	GO:0007129	homologous chromosome pairing at meiosis	"The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]	OMA
NV2t002080001.1	biological_process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]	OMA
NV2t002080001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t002080001.1	biological_process	GO:1990918	double-strand break repair involved in meiotic recombination	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination." [GOC:mah, PMID:15238514]	OMA
NV2t002080001.1	biological_process	GO:1990918	double-strand break repair involved in meiotic recombination	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination." [GOC:mah, PMID:15238514]	PANTHER
NV2t002080001.1	cellular_component	GO:0000793	condensed chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]	OMA
NV2t002080001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002080001.1	molecular_function	GO:0070182	DNA polymerase binding	"Binding to a DNA polymerase." [GOC:BHF, GOC:mah]	OMA
NV2t002084001.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t002084001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t002084001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t002084001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t002084001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	OMA
NV2t002084001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t002086001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t002086001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t002087001.1	biological_process	GO:0006892	post-Golgi vesicle-mediated transport	"The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]	OMA
NV2t002087001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t002087001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t002087001.1	cellular_component	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	OMA
NV2t002087001.1	cellular_component	GO:1990075	periciliary membrane compartment	"A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis." [GOC:cilia, GOC:dr, GOC:krc, PMID:22342749]	PANTHER
NV2t002087001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t002087001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t002088001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	PANTHER
NV2t002088001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t002088001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002088002.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	PANTHER
NV2t002088002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t002088002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002088003.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	PANTHER
NV2t002088003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002088003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002088003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002090001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t002090001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t002090001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t002090001.1	biological_process	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t002090001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t002090001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t002090001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t002090001.1	biological_process	GO:0040012	regulation of locomotion	"Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]	OMA
NV2t002090001.1	biological_process	GO:1903204	obsolete negative regulation of oxidative stress-induced neuron death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	OMA
NV2t002090001.1	biological_process	GO:1903206	obsolete negative regulation of hydrogen peroxide-induced cell death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14749723, PMID:24252804]	OMA
NV2t002090001.1	biological_process	GO:1903599	positive regulation of autophagy of mitochondrion	"Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002]	OMA
NV2t002090001.1	biological_process	GO:1903599	positive regulation of autophagy of mitochondrion	"Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002]	PANTHER
NV2t002090001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002090001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t002090001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002090001.1	cellular_component	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	OMA
NV2t002090001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t002090001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t002090001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002090001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t002090001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t002090001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t002090001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t002090001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t002090002.1	biological_process	GO:1903599	positive regulation of autophagy of mitochondrion	"Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002]	PANTHER
NV2t002090002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002091001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t002091001.1	biological_process	GO:0035494	SNARE complex disassembly	"The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877]	OMA
NV2t002091001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	OMA
NV2t002091001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t002091001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t002091001.1	cellular_component	GO:0005795	Golgi stack	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]	OMA
NV2t002091001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002091001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002091001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002091001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t002092001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t002092001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t002092001.1	molecular_function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]	OMA
NV2t002092001.1	molecular_function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]	PANTHER
NV2t002093001.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t002093001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t002093001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002093001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t002093001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t002093002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002094001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t002094001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002094001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t002095001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002095002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002096001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t002096001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t002096001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002096001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t002096001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t002109001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002109001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t002114001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002115001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002115001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t002115001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002115002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002115002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t002115002.1	biological_process	GO:0010976	positive regulation of neuron projection development	"Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t002115002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t002115002.1	biological_process	GO:0032091	negative regulation of protein binding	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t002115002.1	biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	OMA
NV2t002115002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002115002.1	biological_process	GO:0046827	positive regulation of protein export from nucleus	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]	OMA
NV2t002115002.1	biological_process	GO:0051149	positive regulation of muscle cell differentiation	"Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]	OMA
NV2t002115002.1	biological_process	GO:0051823	regulation of synapse structural plasticity	"Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123]	OMA
NV2t002115002.1	biological_process	GO:0060142	regulation of syncytium formation by plasma membrane fusion	"Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]	OMA
NV2t002115002.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t002115002.1	biological_process	GO:1901985	positive regulation of protein acetylation	"Any process that activates or increases the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195]	OMA
NV2t002115002.1	molecular_function	GO:0004683	calmodulin-dependent protein kinase activity	"Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah, PMID:11264466]	OMA
NV2t002115002.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t002115002.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t002115002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002115002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002115003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002115003.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t002115003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002115004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002115004.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t002115004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002115005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002115005.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t002115005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002117001.1	biological_process	GO:0006474	N-terminal protein amino acid acetylation	"The acetylation of the N-terminal amino acid of proteins." [GOC:ai]	OMA
NV2t002117001.1	cellular_component	GO:0031415	NatA complex	"A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471]	OMA
NV2t002117001.1	molecular_function	GO:0004596	peptide alpha-N-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [GOC:mah, PMID:30054468]	OMA
NV2t002117001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t002117001.1	molecular_function	GO:1990190	peptide-glutamate-alpha-N-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide." [GOC:al, PMID:23912279]	PANTHER
NV2t002118001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002118001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t002118001.1	molecular_function	GO:0046974	histone H3K9 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein." [GOC:ai]	PANTHER
NV2t002119001.1	biological_process	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002120001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002120001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t002120001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t002120001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002120001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t002120002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002120002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t002122001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002122001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002127001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t002127001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t002127001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t002127001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t002127001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002127001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002127001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002127001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t002128001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t002128001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002128001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t002128001.1	molecular_function	GO:0071933	Arp2/3 complex binding	"Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)." [GOC:mah]	PANTHER
NV2t002129001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002129001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t002129001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002129001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002129001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002129001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t002129002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002129002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002129002.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t002129003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002129003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002129003.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t002129004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002129004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002129004.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t002129005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002129005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002129005.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t002129006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002129006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002129006.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t002130001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002132001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t002132001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t002132001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t002137001.1	biological_process	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	PANTHER
NV2t002138001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t002138001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t002138001.1	molecular_function	GO:0004602	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]	OMA
NV2t002139001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002139001.1	molecular_function	GO:1990757	ubiquitin ligase activator activity	"Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242]	PANTHER
NV2t002140001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t002141001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t002141001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t002141001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t002144001.1	biological_process	GO:0007094	mitotic spindle assembly checkpoint signaling	"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]	OMA
NV2t002144001.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	OMA
NV2t002144001.1	cellular_component	GO:1990423	RZZ complex	"A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]	InterPro
NV2t002144001.1	cellular_component	GO:1990423	RZZ complex	"A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]	OMA
NV2t002148001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002148001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002150001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t002150001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t002150001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002151001.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t002151001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002151002.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t002151002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002151002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002151002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t002151003.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t002151003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002151003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002151003.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t002151004.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t002151004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002151004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002151004.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t002152001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002156001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002156001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002157001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002160001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002160002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002160003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002160004.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002160005.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002160006.1	biological_process	GO:0006497	protein lipidation	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]	OMA
NV2t002160006.1	biological_process	GO:0006688	glycosphingolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators]	OMA
NV2t002160006.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t002160006.1	biological_process	GO:0009913	epidermal cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]	OMA
NV2t002160006.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t002160006.1	biological_process	GO:0019221	cytokine-mediated signaling pathway	"The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]	OMA
NV2t002160006.1	biological_process	GO:0032870	cellular response to hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]	OMA
NV2t002160006.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t002160006.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t002160006.1	biological_process	GO:0048666	neuron development	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]	OMA
NV2t002160006.1	biological_process	GO:0071709	membrane assembly	"The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]	OMA
NV2t002160006.1	biological_process	GO:0098856	intestinal lipid absorption	"A process in which lipids are taken up from the contents of the intestine." [GOC:dos, GOC:sl, PMID:18768481]	OMA
NV2t002160006.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t002160006.1	molecular_function	GO:0008120	ceramide glucosyltransferase activity	"Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80]	OMA
NV2t002160006.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002161001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t002161001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	OMA
NV2t002161001.1	cellular_component	GO:0009368	endopeptidase Clp complex	"A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464]	OMA
NV2t002161001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t002161001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t002161001.1	molecular_function	GO:0051117	ATPase binding	"Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai]	PANTHER
NV2t002161001.1	molecular_function	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	OMA
NV2t002162001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002163001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002165001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002165001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002168001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002168001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002169001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	PANTHER
NV2t002169001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002186001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002186001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002189001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t002189001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002189002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t002189002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002189003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t002189003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t002189003.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t002189003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002189003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002193001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t002193001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t002193001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	OMA
NV2t002193001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	PANTHER
NV2t002193001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002193001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t002193001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t002196001.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	InterPro
NV2t002196002.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	InterPro
NV2t002196002.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	OMA
NV2t002196002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002196002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002196002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002196003.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	InterPro
NV2t002196003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002197001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t002197001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t002197001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t002197001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t002197001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002197001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t002199001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t002199001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t002199001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	OMA
NV2t002199001.1	molecular_function	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	"Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators]	InterPro
NV2t002199002.1	molecular_function	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	"Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators]	InterPro
NV2t002201001.1	biological_process	GO:0000245	spliceosomal complex assembly	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]	OMA
NV2t002201001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	InterPro
NV2t002201001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t002201001.1	biological_process	GO:0051100	negative regulation of binding	"Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]	OMA
NV2t002201001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t002201001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002201001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	OMA
NV2t002201001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	PANTHER
NV2t002201001.1	cellular_component	GO:0097504	Gemini of coiled bodies	"Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, PMID:11031238, PMID:9683623, Wikipedia:Cell_nucleus#Cajal_bodies_and_gems]	OMA
NV2t002201001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002201001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t002202001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t002202001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t002202001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002202002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t002202003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t002202003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002203001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t002203001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t002203001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t002203002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t002205001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002208001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t002208002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t002209001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002209001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002209001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002210001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t002210001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t002210001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	PANTHER
NV2t002210001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t002210001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002212001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002215001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t002216001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002216002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002216003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002216004.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t002216004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002217001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t002217001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t002217001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t002217001.1	biological_process	GO:0006425	glutaminyl-tRNA aminoacylation	"The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t002217001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t002217001.1	biological_process	GO:0043039	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	InterPro
NV2t002217001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002217001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t002217001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	PANTHER
NV2t002217001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t002217001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002225001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002225002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002226001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t002226001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002226001.1	molecular_function	GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358]	PANTHER
NV2t002226002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t002226002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t002226002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002226002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002226002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002226002.1	molecular_function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease]	OMA
NV2t002226002.1	molecular_function	GO:0004519	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t002226002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t002226002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002226002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002226002.1	molecular_function	GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358]	OMA
NV2t002226002.1	molecular_function	GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358]	PANTHER
NV2t002228001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t002228001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t002228001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002228001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002229001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t002229001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t002229001.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	InterPro
NV2t002229001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t002229001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t002229001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002229001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002229001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002230001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t002230001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t002230002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t002230002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t002230003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t002230003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t002235001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002237001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002237001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002237001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002241001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t002243001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243002.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t002243003.1	biological_process	GO:0043951	negative regulation of cAMP-mediated signaling	"Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling." [GOC:jl]	OMA
NV2t002243003.1	biological_process	GO:0055117	regulation of cardiac muscle contraction	"Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]	OMA
NV2t002243003.1	biological_process	GO:1903115	regulation of actin filament-based movement	"Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735]	OMA
NV2t002243003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002243003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002243003.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t002243003.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243003.1	molecular_function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	"Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+." [GOC:ai, RHEA:25277]	OMA
NV2t002243003.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243003.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t002243003.1	molecular_function	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	OMA
NV2t002243004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243004.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243004.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243005.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243005.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243006.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243006.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243007.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243007.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243007.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243008.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243008.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243008.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243009.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243009.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243009.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243010.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243010.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243010.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243011.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243011.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243011.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002243013.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002243013.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	PANTHER
NV2t002243013.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002244001.1	cellular_component	GO:0043529	GET complex	"An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins." [GOC:krc, GOC:vw, PMID:16269340, PMID:18724936, PMID:32910895]	PANTHER
NV2t002244001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002245001.1	biological_process	GO:0006529	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	InterPro
NV2t002245001.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t002245001.1	molecular_function	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532]	OMA
NV2t002247001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t002247001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t002247001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t002247001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002247001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002247001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t002247001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	OMA
NV2t002247002.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t002247002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002247002.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t002248001.1	biological_process	GO:0006529	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	InterPro
NV2t002248002.1	biological_process	GO:0006529	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	InterPro
NV2t002248002.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t002248002.1	molecular_function	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532]	OMA
NV2t002249001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002249001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t002249001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t002249001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t002249001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002249002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002249002.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t002252001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	PANTHER
NV2t002255001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t002255001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t002255001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t002255001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002255001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002255001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t002257001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002257001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t002258001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002258001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t002260002.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t002260002.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t002260002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t002260002.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002260002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t002260002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t002260002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t002260002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t002261001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002261001.1	molecular_function	GO:0031405	lipoic acid binding	"Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t002261002.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002261002.1	molecular_function	GO:0031405	lipoic acid binding	"Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t002262001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002262001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002262001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002265001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002265001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t002265001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t002265001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t002265001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	PANTHER
NV2t002265001.1	biological_process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t002265001.1	biological_process	GO:0045725	positive regulation of glycogen biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	OMA
NV2t002265001.1	biological_process	GO:0070884	regulation of calcineurin-NFAT signaling cascade	"Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai]	OMA
NV2t002265001.1	biological_process	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t002265001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t002265001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002265001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002265001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t002265001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t002265001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t002265001.1	molecular_function	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	InterPro
NV2t002265001.1	molecular_function	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	OMA
NV2t002265001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t002265001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002265001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002265001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t002266001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	InterPro
NV2t002266001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	InterPro
NV2t002266001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002266002.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	InterPro
NV2t002266002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t002266002.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t002266002.1	biological_process	GO:0055072	obsolete iron ion homeostasis	"OBSOLETE. Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	OMA
NV2t002266002.1	biological_process	GO:0055072	obsolete iron ion homeostasis	"OBSOLETE. Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	PANTHER
NV2t002266002.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t002266002.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t002266002.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t002266002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002268002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002268002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002268004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002269001.1	biological_process	GO:0006450	regulation of translational fidelity	"Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]	OMA
NV2t002269001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t002269001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002269001.1	biological_process	GO:0051083	'de novo' cotranslational protein folding	"The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb]	PANTHER
NV2t002269001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002269001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002269001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t002269001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t002269001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t002269001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t002269001.1	molecular_function	GO:0140036	ubiquitin-modified protein reader activity	"A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way." [PMID:26060076]	OMA
NV2t002270001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002270001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002270001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002270001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002270002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002270002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002272001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002272001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002272001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002272001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002272001.1	molecular_function	GO:0015370	solute:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai]	OMA
NV2t002273001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002273001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002289001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t002296001.1	biological_process	GO:0006783	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]	PANTHER
NV2t002296001.1	biological_process	GO:0033014	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	InterPro
NV2t002296001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002296002.1	biological_process	GO:0006783	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]	PANTHER
NV2t002296002.1	biological_process	GO:0033014	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	InterPro
NV2t002296002.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t002296002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002296003.1	biological_process	GO:0006783	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]	PANTHER
NV2t002296003.1	biological_process	GO:0033014	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	InterPro
NV2t002296003.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t002296003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002296004.1	biological_process	GO:0006783	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]	PANTHER
NV2t002296004.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t002296004.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t002296004.1	biological_process	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	OMA
NV2t002296004.1	biological_process	GO:0033014	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	InterPro
NV2t002296004.1	biological_process	GO:0034645	obsolete cellular macromolecule biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [GOC:mah]	OMA
NV2t002296004.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t002296004.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t002296004.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t002296004.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t002296004.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t002296004.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t002296004.1	molecular_function	GO:0016410	N-acyltransferase activity	"Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t002296004.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t002296004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002296004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t002296005.1	biological_process	GO:0006783	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]	PANTHER
NV2t002296005.1	biological_process	GO:0033014	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	InterPro
NV2t002296005.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t002296005.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002296006.1	biological_process	GO:0006783	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]	PANTHER
NV2t002296006.1	biological_process	GO:0033014	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	InterPro
NV2t002296006.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t002296006.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002297001.1	biological_process	GO:0015850	organic hydroxy compound transport	"The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]	OMA
NV2t002297001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002297001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002297001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002297001.1	molecular_function	GO:0008028	monocarboxylic acid transmembrane transporter activity	"Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]	OMA
NV2t002297001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t002297001.1	molecular_function	GO:1901618	organic hydroxy compound transmembrane transporter activity	"Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t002297001.1	molecular_function	GO:1901702	salt transmembrane transporter activity	"Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t002298001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t002298001.1	biological_process	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	OMA
NV2t002298001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002298001.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	InterPro
NV2t002298001.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	OMA
NV2t002298001.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	PANTHER
NV2t002301001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t002301001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t002301001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002301001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t002301001.1	molecular_function	GO:0008276	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]	InterPro
NV2t002301001.1	molecular_function	GO:0008276	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]	OMA
NV2t002302001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t002302001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002302001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002302001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002302001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002306001.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t002306001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t002306001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t002306001.1	biological_process	GO:0043649	dicarboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t002306001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002306001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002306001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	OMA
NV2t002306001.1	molecular_function	GO:0016155	formyltetrahydrofolate dehydrogenase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH." [EC:1.5.1.6, RHEA:10180]	PANTHER
NV2t002306001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t002306001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t002306001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t002306001.1	molecular_function	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2.-, GOC:mah]	OMA
NV2t002306002.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t002306002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002306002.1	molecular_function	GO:0016155	formyltetrahydrofolate dehydrogenase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH." [EC:1.5.1.6, RHEA:10180]	PANTHER
NV2t002306002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t002306003.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t002306003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002306003.1	molecular_function	GO:0016155	formyltetrahydrofolate dehydrogenase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH." [EC:1.5.1.6, RHEA:10180]	PANTHER
NV2t002306003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t002306004.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t002306004.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002306004.1	molecular_function	GO:0016155	formyltetrahydrofolate dehydrogenase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH." [EC:1.5.1.6, RHEA:10180]	PANTHER
NV2t002306004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t002306005.1	molecular_function	GO:0016155	formyltetrahydrofolate dehydrogenase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH." [EC:1.5.1.6, RHEA:10180]	PANTHER
NV2t002306005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t002306005.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t002307001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t002307001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002307001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002309001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t002309001.1	biological_process	GO:0044242	cellular lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t002309001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t002309001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t002309001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	InterPro
NV2t002309001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t002309002.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	InterPro
NV2t002309003.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	InterPro
NV2t002310001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	PANTHER
NV2t002310001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002310002.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	PANTHER
NV2t002310002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t002310002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002310003.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	PANTHER
NV2t002310003.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t002310003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002313001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002313001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t002313001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002313001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002313001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002313001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t002313001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002313001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002313002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002313002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002313002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002313002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002313002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002313003.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002313003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002313003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002313003.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002313003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002314001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002314001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002314001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002314001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002314001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002314002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002314002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002314002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002314002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002314002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002314003.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002314003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002314003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002314003.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002314003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002314004.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002314004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002314004.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002314004.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002314004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002315001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002315001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002315001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002315001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002315001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002315002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002315002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002315002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002315002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002315002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002315003.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002315003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002315003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002315003.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002315003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002315004.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t002315004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002315004.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002315004.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t002315004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002320001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t002322001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t002322001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002322001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002322001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002324001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t002324001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002324001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002324001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002325001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002325001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002327001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t002327001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002327002.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t002327002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002327003.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t002327003.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t002327003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002327003.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t002327003.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t002328001.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t002328002.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t002328003.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t002349001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t002349001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t002351001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t002351001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002351001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002351001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002351001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002356001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t002356001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t002356001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t002359001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002359001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t002361001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t002361002.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t002361003.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t002361004.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t002364001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t002366001.1	biological_process	GO:0007423	sensory organ development	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]	OMA
NV2t002366001.1	biological_process	GO:0007605	sensory perception of sound	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]	OMA
NV2t002366001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	OMA
NV2t002366001.1	biological_process	GO:0050974	detection of mechanical stimulus involved in sensory perception	"The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]	OMA
NV2t002366001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002366001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002367001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t002367001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t002368001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002371001.1	biological_process	GO:0043928	obsolete exonucleolytic catabolism of deadenylated mRNA	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo]	PANTHER
NV2t002371001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002371002.1	biological_process	GO:0043928	obsolete exonucleolytic catabolism of deadenylated mRNA	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo]	PANTHER
NV2t002371002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002371003.1	biological_process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	OMA
NV2t002371003.1	biological_process	GO:0000291	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]	OMA
NV2t002371003.1	biological_process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]	OMA
NV2t002371003.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t002371003.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t002371003.1	biological_process	GO:0031047	regulatory ncRNA-mediated gene silencing	"A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation." [PMID:15020054]	OMA
NV2t002371003.1	biological_process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	"Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]	OMA
NV2t002371003.1	biological_process	GO:0043928	obsolete exonucleolytic catabolism of deadenylated mRNA	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo]	PANTHER
NV2t002371003.1	biological_process	GO:0045069	regulation of viral genome replication	"Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai]	OMA
NV2t002371003.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t002371003.1	biological_process	GO:0048524	positive regulation of viral process	"Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]	OMA
NV2t002371003.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t002371003.1	biological_process	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]	OMA
NV2t002371003.1	biological_process	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	OMA
NV2t002371003.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t002371003.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t002371003.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	OMA
NV2t002371003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002371003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002371003.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t002371003.1	molecular_function	GO:0004535	poly(A)-specific ribonuclease activity	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]	OMA
NV2t002371003.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	OMA
NV2t002371004.1	biological_process	GO:0043928	obsolete exonucleolytic catabolism of deadenylated mRNA	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo]	PANTHER
NV2t002371004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002372001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t002372001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002372001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t002373001.1	molecular_function	GO:0016531	copper chaperone activity	"Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376]	PANTHER
NV2t002373001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002373002.1	biological_process	GO:0006825	copper ion transport	"The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t002373002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002373002.1	molecular_function	GO:0016531	copper chaperone activity	"Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376]	OMA
NV2t002373002.1	molecular_function	GO:0016531	copper chaperone activity	"Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376]	PANTHER
NV2t002373002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002373002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t002374001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t002374001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t002374001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t002374001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002374001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t002374001.1	biological_process	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	OMA
NV2t002374001.1	biological_process	GO:0090287	regulation of cellular response to growth factor stimulus	"Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]	OMA
NV2t002374001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t002374001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002374001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t002374001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002375001.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t002375001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t002375001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002375001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t002375001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t002375001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t002377001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t002377001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002378001.1	biological_process	GO:0046330	positive regulation of JNK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	InterPro
NV2t002378001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002379001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t002379001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t002379001.1	biological_process	GO:0031144	proteasome localization	"Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t002379001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t002379001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002379001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t002379001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t002379001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t002384001.1	biological_process	GO:0032785	negative regulation of DNA-templated transcription, elongation	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	OMA
NV2t002384001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t002384001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	OMA
NV2t002384001.1	biological_process	GO:0071027	nuclear RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]	OMA
NV2t002384001.1	biological_process	GO:0140747	obsolete regulation of ncRNA transcription	"OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template." [GOC:pg]	OMA
NV2t002384001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t002384001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t002384001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002384001.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t002384001.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	OMA
NV2t002384001.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	PANTHER
NV2t002384001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t002384001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002384001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002385001.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t002386001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t002386001.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t002386001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t002386002.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t002386003.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t002386004.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t002388001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t002388002.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t002388003.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t002388004.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t002388005.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t002388006.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t002388007.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t002392001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t002392002.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t002392003.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t002392004.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t002399001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t002399001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t002399001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t002402001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t002402001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t002402001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002402001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t002402002.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t002402002.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t002402003.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t002402003.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t002407001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	InterPro
NV2t002407001.1	biological_process	GO:0045161	neuronal ion channel clustering	"The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440]	OMA
NV2t002407001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t002407001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002407001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t002407001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t002407001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t002407001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t002407001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002409001.1	molecular_function	GO:0005540	hyaluronic acid binding	"Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl]	InterPro
NV2t002412001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	PANTHER
NV2t002412002.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	PANTHER
NV2t002420001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002420001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t002421001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002421001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002421001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002422001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002422001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002422001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002422001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002422001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002422001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t002424001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t002424001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	PANTHER
NV2t002425001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	PANTHER
NV2t002425001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002425002.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	PANTHER
NV2t002425002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002426001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t002426001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002426001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002426001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002428001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002428001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t002428001.1	biological_process	GO:0035331	negative regulation of hippo signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]	OMA
NV2t002428001.1	biological_process	GO:0043410	positive regulation of MAPK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]	OMA
NV2t002428001.1	biological_process	GO:0046621	negative regulation of organ growth	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]	OMA
NV2t002428001.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t002428001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002428001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002428001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t002428001.1	cellular_component	GO:0031256	leading edge membrane	"The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]	OMA
NV2t002428001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t002428001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t002428001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002428001.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	OMA
NV2t002428001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t002428001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	PANTHER
NV2t002429001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t002429001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002429001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002430001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t002430002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t002431001.1	biological_process	GO:0006221	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002431001.1	biological_process	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002431001.1	biological_process	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002431001.1	biological_process	GO:0009219	pyrimidine deoxyribonucleotide metabolic process	"The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002431001.1	biological_process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]	OMA
NV2t002431001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t002431001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t002431001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002431001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t002431001.1	molecular_function	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	OMA
NV2t002431001.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	OMA
NV2t002432001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002432001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t002432002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002432002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t002432003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t002433001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t002433001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t002433001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t002433001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002434001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002434001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002439001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t002439001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002439002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t002439002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002440001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002440001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002440001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002440002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002440002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002440002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002440003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002440003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002440003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002440004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002440004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002440004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002440005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002440005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002440005.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002440006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002440006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002440006.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002440007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002440007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002440007.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002441001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t002443001.1	biological_process	GO:0000086	G2/M transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]	OMA
NV2t002443001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t002443001.1	biological_process	GO:0043153	entrainment of circadian clock by photoperiod	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]	OMA
NV2t002443001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t002443001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002443001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002443001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t002443001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002449001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	PANTHER
NV2t002449002.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	PANTHER
NV2t002451001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	PANTHER
NV2t002452001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002452001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t002452001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t002452002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002452002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t002454001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t002454001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002459001.1	biological_process	GO:0031532	obsolete actin cytoskeleton reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]	PANTHER
NV2t002459001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002459001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t002460001.1	biological_process	GO:0051642	centrosome localization	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t002461001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t002461001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002463001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t002467001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002467001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002472001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t002472001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002474001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002475001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t002475001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	InterPro
NV2t002475001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	OMA
NV2t002477001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t002477001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t002477001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002477001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t002481001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	InterPro
NV2t002481001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t002481002.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	InterPro
NV2t002481002.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t002482001.1	biological_process	GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering	"The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:19556461, PMID:27875684]	PANTHER
NV2t002482001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002482001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t002484001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002484001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t002485001.1	biological_process	GO:0006740	NADPH regeneration	"A metabolic process that generates a pool of NADPH by the reduction of NADP+." [GOC:mah]	OMA
NV2t002485001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t002485001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	OMA
NV2t002485001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t002485001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t002485001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	PANTHER
NV2t002485002.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t002485002.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	PANTHER
NV2t002485003.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t002485003.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	PANTHER
NV2t002486001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t002486001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t002486001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t002486001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002487001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002487001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002487001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t002487002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002487002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t002488001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002488001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t002488002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002488002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t002488003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002488003.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t002489001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	PANTHER
NV2t002490001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002490001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t002490001.1	molecular_function	GO:0000987	cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018]	OMA
NV2t002490001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	PANTHER
NV2t002503001.1	biological_process	GO:0002009	morphogenesis of an epithelium	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]	OMA
NV2t002503001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t002503001.1	biological_process	GO:0021675	nerve development	"The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t002503001.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	InterPro
NV2t002503001.1	cellular_component	GO:0016011	dystroglycan complex	"A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609]	OMA
NV2t002503001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002503001.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t002503001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002503001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002503001.1	molecular_function	GO:0043236	laminin binding	"Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd]	PANTHER
NV2t002503001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	OMA
NV2t002504001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002504001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t002506001.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t002506001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t002506002.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	OMA
NV2t002506002.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t002506002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t002506002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t002506003.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t002506003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t002507001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	PANTHER
NV2t002507001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002508001.1	biological_process	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	InterPro
NV2t002508002.1	biological_process	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	InterPro
NV2t002508007.1	biological_process	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	InterPro
NV2t002508007.1	biological_process	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	OMA
NV2t002508007.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t002509001.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	InterPro
NV2t002509001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002509001.1	molecular_function	GO:0043236	laminin binding	"Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd]	PANTHER
NV2t002509002.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	InterPro
NV2t002509002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002509002.1	molecular_function	GO:0043236	laminin binding	"Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd]	PANTHER
NV2t002509003.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	InterPro
NV2t002509003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002509003.1	molecular_function	GO:0043236	laminin binding	"Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd]	PANTHER
NV2t002509004.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	InterPro
NV2t002509004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002509004.1	molecular_function	GO:0043236	laminin binding	"Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd]	PANTHER
NV2t002509005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002509005.1	molecular_function	GO:0043236	laminin binding	"Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd]	PANTHER
NV2t002510001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t002510001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002510001.1	molecular_function	GO:0008887	glycerate kinase activity	"Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+." [EC:2.7.1.31, RHEA:23516]	PANTHER
NV2t002510001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t002510001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t002511001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t002511001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t002511001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002511001.1	molecular_function	GO:0005220	inositol 1,4,5-trisphosphate-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:28416699, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor]	OMA
NV2t002511001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t002511001.1	molecular_function	GO:0043178	alcohol binding	"Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]	OMA
NV2t002511001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	InterPro
NV2t002511001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t002511002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t002511002.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	InterPro
NV2t002511002.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t002511003.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t002511003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002513001.1	molecular_function	GO:0009019	obsolete tRNA (guanine-N1-)-methyltransferase activity	"OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [GOC:curators, PMID:782564]	PANTHER
NV2t002514001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t002515001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002515001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t002515001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t002515001.1	molecular_function	GO:0004556	alpha-amylase activity	"Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [PMID:12527308]	OMA
NV2t002515001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002518001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t002518001.1	cellular_component	GO:0032783	super elongation complex	"A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae." [PMID:17150956, PMID:30102332]	PANTHER
NV2t002518002.1	cellular_component	GO:0032783	super elongation complex	"A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae." [PMID:17150956, PMID:30102332]	PANTHER
NV2t002519001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t002519001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t002519001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t002519001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t002519001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	OMA
NV2t002519001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t002519001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t002519001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002519001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t002519001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t002519001.1	cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]	OMA
NV2t002519001.1	cellular_component	GO:0031466	Cul5-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t002519001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t002519001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002519001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002519001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t002519001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t002519001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t002519001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t002519001.1	molecular_function	GO:0061663	NEDD8 ligase activity	"Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]	OMA
NV2t002519001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	OMA
NV2t002519001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t002523001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t002523001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t002523001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t002523001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t002527001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002527002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002527002.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t002527003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002527003.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t002527004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002527004.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t002528001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t002528001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t002529002.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	InterPro
NV2t002529002.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	PANTHER
NV2t002529002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002529002.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t002529002.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	OMA
NV2t002530001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t002530001.1	biological_process	GO:0110051	metabolite repair	"A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, PMID:23334546, PMID:28373563]	PANTHER
NV2t002530001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	InterPro
NV2t002530001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t002530002.1	biological_process	GO:0110051	metabolite repair	"A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, PMID:23334546, PMID:28373563]	PANTHER
NV2t002530002.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	InterPro
NV2t002530003.1	biological_process	GO:0110051	metabolite repair	"A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, PMID:23334546, PMID:28373563]	PANTHER
NV2t002530003.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	InterPro
NV2t002532001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t002532001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t002532001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002532002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t002532002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t002532002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002533001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t002533001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t002533001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t002534001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002534002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002534003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002534004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002537001.1	cellular_component	GO:0072380	TRC complex	"A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane." [GOC:mah, PMID:20850366, PMID:23142665]	PANTHER
NV2t002537001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002538001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t002538001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t002538001.1	biological_process	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	OMA
NV2t002538001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t002538001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t002538001.1	cellular_component	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	"A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838]	PANTHER
NV2t002538001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002538001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t002538001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002539001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t002539001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t002539001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t002539001.1	biological_process	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	OMA
NV2t002539001.1	biological_process	GO:0031638	zymogen activation	"The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]	OMA
NV2t002539001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t002539001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t002539001.1	biological_process	GO:0051093	negative regulation of developmental process	"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t002539001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t002539001.1	biological_process	GO:0061615	glycolytic process through fructose-6-phosphate	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479]	OMA
NV2t002539001.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	OMA
NV2t002539001.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t002539001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t002539001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002539001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t002539001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002539001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t002539001.1	molecular_function	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl]	OMA
NV2t002539001.1	molecular_function	GO:0043531	ADP binding	"Binding to ADP, adenosine 5'-diphosphate." [GOC:jl]	PANTHER
NV2t002539001.1	molecular_function	GO:0047134	protein-disulfide reductase (NAD(P)H) activity	"Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]	OMA
NV2t002540001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t002540001.1	biological_process	GO:0031324	negative regulation of cellular metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t002540001.1	biological_process	GO:0043457	regulation of cellular respiration	"Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl]	OMA
NV2t002540001.1	biological_process	GO:1903206	obsolete negative regulation of hydrogen peroxide-induced cell death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14749723, PMID:24252804]	OMA
NV2t002540001.1	biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t002540001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t002540001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t002540001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t002540001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002540001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002540001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t002540001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t002540001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t002540001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t002540001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t002542001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t002542001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002542001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t002542001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t002542001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t002542001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002542001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t002542001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t002542001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002544001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002545001.1	biological_process	GO:0003400	regulation of COPII vesicle coating	"Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t002545001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t002545001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t002545001.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t002545001.1	biological_process	GO:0016050	vesicle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]	OMA
NV2t002545001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	OMA
NV2t002545001.1	biological_process	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002545001.1	cellular_component	GO:0030120	vesicle coat	"A membrane coat found on a coated vesicle." [GOC:mah]	OMA
NV2t002545001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t002545001.1	cellular_component	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	OMA
NV2t002545001.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	OMA
NV2t002545001.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t002545001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t002545001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002545001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t002545002.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t002545002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002545003.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t002545003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002545004.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t002545004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002546001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002546001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002547001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002547001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002549001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002549001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002549001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002549001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t002549001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t002549001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002552001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	InterPro
NV2t002552001.1	molecular_function	GO:0072572	poly-ADP-D-ribose binding	"Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964]	PANTHER
NV2t002554001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	InterPro
NV2t002554001.1	molecular_function	GO:0072572	poly-ADP-D-ribose binding	"Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964]	PANTHER
NV2t002554002.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t002554002.1	biological_process	GO:0031056	obsolete regulation of histone modification	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]	OMA
NV2t002554002.1	biological_process	GO:0051338	regulation of transferase activity	"Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai]	OMA
NV2t002554002.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t002554002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002554002.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	OMA
NV2t002554002.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t002554002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	InterPro
NV2t002554002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t002554002.1	molecular_function	GO:0072572	poly-ADP-D-ribose binding	"Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964]	OMA
NV2t002554002.1	molecular_function	GO:0072572	poly-ADP-D-ribose binding	"Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964]	PANTHER
NV2t002555001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	OMA
NV2t002555001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	PANTHER
NV2t002555001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002555001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002556001.1	biological_process	GO:0030177	positive regulation of Wnt signaling pathway	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t002556001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t002556001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t002556001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002556001.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t002556001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t002556001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t002557001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t002557001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002557001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t002557001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t002558001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t002558001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002558002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t002558002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002562001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002566001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002571001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002575001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002577001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	InterPro
NV2t002577001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	PANTHER
NV2t002577001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t002577002.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	InterPro
NV2t002577002.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	PANTHER
NV2t002577002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t002577003.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t002577003.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	InterPro
NV2t002577003.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t002577003.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	PANTHER
NV2t002577003.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t002577003.1	biological_process	GO:0032886	regulation of microtubule-based process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]	OMA
NV2t002577003.1	biological_process	GO:0035372	protein localization to microtubule	"A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb]	OMA
NV2t002577003.1	biological_process	GO:0051282	regulation of sequestering of calcium ion	"Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]	OMA
NV2t002577003.1	biological_process	GO:0051493	regulation of cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	OMA
NV2t002577003.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t002577003.1	biological_process	GO:0071417	cellular response to organonitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah]	OMA
NV2t002577003.1	biological_process	GO:1903169	regulation of calcium ion transmembrane transport	"Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847]	OMA
NV2t002577003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002577003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002577003.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t002577003.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t002577003.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t002577003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t002577003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t002577003.1	molecular_function	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	OMA
NV2t002578001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t002578001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t002578001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t002578001.1	biological_process	GO:0007006	mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t002578001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t002578001.1	biological_process	GO:0010823	obsolete negative regulation of mitochondrion organization	"OBSOLETE. Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	OMA
NV2t002578001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t002578001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t002578001.1	biological_process	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t002578001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002578001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t002578001.1	biological_process	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	OMA
NV2t002578001.1	biological_process	GO:0072530	purine-containing compound transmembrane transport	"The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t002578001.1	biological_process	GO:1901526	positive regulation of mitophagy	"Any process that activates or increases the frequency, rate or extent of mitophagy." [GOC:TermGenie]	OMA
NV2t002578001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	OMA
NV2t002578001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t002578001.1	biological_process	GO:1990544	mitochondrial ATP transmembrane transport	"The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:18485069]	InterPro
NV2t002578001.1	biological_process	GO:1990845	adaptive thermogenesis	"The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363]	OMA
NV2t002578001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t002578001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t002578001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t002578001.1	cellular_component	GO:0042645	mitochondrial nucleoid	"The region of a mitochondrion to which the DNA is confined." [GOC:jl]	OMA
NV2t002578001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t002578001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t002578001.1	molecular_function	GO:0005471	ATP:ADP antiporter activity	"Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1]	OMA
NV2t002578001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t002579001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002579001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t002580001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t002580001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t002580001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t002580001.1	biological_process	GO:0009411	response to UV	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]	OMA
NV2t002580001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t002580001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t002580001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	OMA
NV2t002580001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t002580001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t002580001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t002580001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t002580001.1	cellular_component	GO:0031371	ubiquitin conjugating enzyme complex	"Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah]	OMA
NV2t002580001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t002580001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t002580001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t002584001.1	molecular_function	GO:0034237	protein kinase A regulatory subunit binding	"Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah]	PANTHER
NV2t002585001.1	molecular_function	GO:0004423	iduronate-2-sulfatase activity	"Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13]	InterPro
NV2t002585001.1	molecular_function	GO:0004423	iduronate-2-sulfatase activity	"Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13]	OMA
NV2t002585001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	PANTHER
NV2t002587001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002587001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t002589001.1	biological_process	GO:0006448	regulation of translational elongation	"Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]	OMA
NV2t002589001.1	biological_process	GO:0018202	peptidyl-histidine modification	"The modification of peptidyl-histidine." [GOC:ma]	OMA
NV2t002589001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t002589001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t002590001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t002590001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t002590001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t002590001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t002591001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	InterPro
NV2t002591001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t002591001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	OMA
NV2t002591001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t002591001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t002591001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t002595001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t002595001.1	biological_process	GO:0097035	regulation of membrane lipid distribution	"Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909]	PANTHER
NV2t002595001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t002598001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t002598001.1	biological_process	GO:0033108	mitochondrial respiratory chain complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]	OMA
NV2t002598001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t002598001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t002599001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002599002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002600001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002600001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002600001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t002600001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t002600001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002600001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t002601001.1	biological_process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw]	PANTHER
NV2t002606001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002608001.1	cellular_component	GO:0035371	microtubule plus-end	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]	PANTHER
NV2t002608003.1	cellular_component	GO:0035371	microtubule plus-end	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]	PANTHER
NV2t002608004.1	biological_process	GO:0007020	microtubule nucleation	"The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]	OMA
NV2t002608004.1	biological_process	GO:0031116	positive regulation of microtubule polymerization	"Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah]	OMA
NV2t002608004.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t002608004.1	cellular_component	GO:0035371	microtubule plus-end	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]	OMA
NV2t002608004.1	cellular_component	GO:0035371	microtubule plus-end	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]	PANTHER
NV2t002609001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002609002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002609003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002609003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t002610001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002610001.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	PANTHER
NV2t002610002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002610002.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	PANTHER
NV2t002610003.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	PANTHER
NV2t002610004.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	PANTHER
NV2t002610005.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	PANTHER
NV2t002612001.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	InterPro
NV2t002615001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t002615001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t002615001.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	InterPro
NV2t002615001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t002615001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t002615002.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t002615002.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	InterPro
NV2t002615003.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t002615003.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	InterPro
NV2t002615004.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t002615004.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	InterPro
NV2t002615005.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t002615006.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t002617001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t002617001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002617001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002617001.1	molecular_function	GO:0004984	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	OMA
NV2t002618001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t002618001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t002618001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t002618001.1	molecular_function	GO:0050699	WW domain binding	"Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730]	PANTHER
NV2t002618002.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t002618002.1	molecular_function	GO:0050699	WW domain binding	"Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730]	PANTHER
NV2t002618003.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t002618003.1	molecular_function	GO:0050699	WW domain binding	"Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730]	PANTHER
NV2t002630001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t002630001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002630002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t002630003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t002631001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t002634001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t002634001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	InterPro
NV2t002634001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t002635001.1	biological_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	InterPro
NV2t002635001.1	biological_process	GO:0019646	aerobic electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]	OMA
NV2t002635001.1	biological_process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]	OMA
NV2t002635001.1	cellular_component	GO:0005746	mitochondrial respirasome	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]	OMA
NV2t002635001.1	cellular_component	GO:0070069	cytochrome complex	"A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah]	OMA
NV2t002635001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t002635001.1	cellular_component	GO:0098803	respiratory chain complex	"Any protein complex that is part of a respiratory chain." [GOC:dos]	OMA
NV2t002635001.1	cellular_component	GO:1902495	transmembrane transporter complex	"A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586]	OMA
NV2t002635001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t002637001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002637001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	InterPro
NV2t002637001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t002637001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002637001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002637001.1	cellular_component	GO:0000123	histone acetyltransferase complex	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]	OMA
NV2t002637001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002637001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t002637001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t002637001.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	InterPro
NV2t002637001.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	OMA
NV2t002637001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002637001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002637001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t002637001.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	OMA
NV2t002640001.1	biological_process	GO:0006556	S-adenosylmethionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002640001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t002640001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t002640001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t002640001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t002640001.1	molecular_function	GO:0048270	methionine adenosyltransferase regulator activity	"Binds to and modulates the activity of methionine adenosyltransferase." [GOC:jid, PMID:10644686]	PANTHER
NV2t002641001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002642001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002642001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t002642001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t002642001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t002642001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t002642001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t002642001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t002642001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002643001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t002643001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t002643001.1	biological_process	GO:0006420	arginyl-tRNA aminoacylation	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t002643001.1	biological_process	GO:0006420	arginyl-tRNA aminoacylation	"The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t002643001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002643001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002643001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t002643001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t002643001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002644001.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t002644002.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t002644003.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t002652001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t002652001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002652001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002653001.1	biological_process	GO:0051493	regulation of cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	OMA
NV2t002653001.1	biological_process	GO:0051493	regulation of cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	PANTHER
NV2t002653001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t002653001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002653001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t002656001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002656001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t002658001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t002658001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t002658001.1	biological_process	GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	"The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474]	PANTHER
NV2t002658001.1	cellular_component	GO:0000178	exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t002658002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t002658002.1	biological_process	GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	"The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474]	PANTHER
NV2t002663001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002664001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002669001.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	PANTHER
NV2t002669002.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t002669002.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	PANTHER
NV2t002669002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002669002.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t002669002.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t002669002.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t002669002.1	molecular_function	GO:0015095	magnesium ion transmembrane transporter activity	"Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t002669003.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	PANTHER
NV2t002669004.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	PANTHER
NV2t002670001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002670001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002670001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t002670002.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	InterPro
NV2t002670002.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t002670002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t002670002.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t002670002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002670002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002670002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002670002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002670002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002670002.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	InterPro
NV2t002670002.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	OMA
NV2t002670002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t002670002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t002670002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t002670003.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	InterPro
NV2t002671001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002671002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002671002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002671002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002672001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t002672001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t002675001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t002675001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t002675001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t002678001.1	biological_process	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	"The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579]	PANTHER
NV2t002678001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002680001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002680001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002684001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t002684001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002684001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002684001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002685001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t002685002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t002685002.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t002685002.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t002686001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t002686001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t002686001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t002686001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t002686001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002686001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002686001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t002686001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t002686001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t002687001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t002687001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t002687001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002687001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t002689001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t002690001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t002690001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002690001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t002690001.1	molecular_function	GO:0097177	mitochondrial ribosome binding	"Binding to a mitochondrial ribosome." [GOC:ans, PMID:20739282]	PANTHER
NV2t002692001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t002692001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t002692001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t002694001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t002694001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t002694001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t002696001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t002696001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t002696001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t002698001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t002698002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002698002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t002699001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t002700001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t002703001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t002703001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	OMA
NV2t002703001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	PANTHER
NV2t002703001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t002703001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t002703001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002703001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002705001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t002705001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002705001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002705001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t002705002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t002705002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002705002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002705002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t002707001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t002707001.1	biological_process	GO:0009913	epidermal cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]	OMA
NV2t002707001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t002707001.1	biological_process	GO:0014068	obsolete positive regulation of phosphatidylinositol 3-kinase signaling	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]	OMA
NV2t002707001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t002707001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t002707001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t002707001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t002707001.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t002707001.1	biological_process	GO:0046330	positive regulation of JNK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	OMA
NV2t002707001.1	biological_process	GO:0050673	epithelial cell proliferation	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]	OMA
NV2t002707001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t002707001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t002707001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t002707001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t002707001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002707001.1	molecular_function	GO:0005109	frizzled binding	"Binding to a frizzled (fz) receptor." [GOC:ceb]	OMA
NV2t002707001.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t002708001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t002708001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	PANTHER
NV2t002708001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002708002.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t002708002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	PANTHER
NV2t002708003.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t002708003.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t002708003.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t002708003.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	PANTHER
NV2t002708003.1	biological_process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	"Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]	OMA
NV2t002708003.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t002708003.1	cellular_component	GO:0031391	Elg1 RFC-like complex	"A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842, PMID:23499004, PMID:27664980]	OMA
NV2t002708003.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002708003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002708003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002708003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002708003.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t002711001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002711001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002711001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t002711001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002713001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002713001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002713002.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002713002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002713003.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002713003.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t002713003.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t002713003.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t002713003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002713003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t002713004.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002713004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002714001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002714001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t002714001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t002714001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t002714001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002714001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t002716001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002716001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t002716001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t002716001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t002716001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002716001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t002717001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002717001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002717002.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002717002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002717003.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002717003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002718001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002718001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002719001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002719001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002719002.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t002719002.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t002719002.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t002719002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002719002.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t002719002.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t002719002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002719002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t002722001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t002722001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t002722001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t002722002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t002722002.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t002722003.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t002722003.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t002722004.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t002722004.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t002722005.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t002722005.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t002726001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t002726001.1	biological_process	GO:0016188	synaptic vesicle maturation	"Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709]	OMA
NV2t002726001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t002726001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t002726001.1	biological_process	GO:0022407	regulation of cell-cell adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]	OMA
NV2t002726001.1	biological_process	GO:0035418	protein localization to synapse	"Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]	OMA
NV2t002726001.1	biological_process	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	OMA
NV2t002726001.1	biological_process	GO:0048168	regulation of neuronal synaptic plasticity	"A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, PMID:11891290]	OMA
NV2t002726001.1	biological_process	GO:0050806	positive regulation of synaptic transmission	"Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]	OMA
NV2t002726001.1	biological_process	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t002726001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t002726001.1	biological_process	GO:0090316	positive regulation of intracellular protein transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t002726001.1	biological_process	GO:0106104	regulation of glutamate receptor clustering	"Any process that modulates the frequency, rate or extent of glutamate receptor clustering." [GOC:ha, PMID:28455372]	OMA
NV2t002726001.1	biological_process	GO:1903078	positive regulation of protein localization to plasma membrane	"Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]	OMA
NV2t002726001.1	biological_process	GO:2001137	positive regulation of endocytic recycling	"Any process that activates or increases the frequency, rate or extent of endocytic recycling." [GOC:obol]	OMA
NV2t002726001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002726001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t002726001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002726001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t002726001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t002726001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t002726001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t002726001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t002726001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t002726002.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t002726003.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t002726004.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t002726005.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t002727001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002727001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t002728001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t002728002.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t002728003.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t002729001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002729001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002729001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002729001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t002730001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002735001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t002735001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t002735001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t002735001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002735001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t002735001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t002737001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737003.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737004.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737005.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737006.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737007.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737008.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737009.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737010.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737011.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737012.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737013.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737014.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737015.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737016.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737017.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002737018.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002738001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002739001.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	PANTHER
NV2t002739002.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	PANTHER
NV2t002739003.1	biological_process	GO:0006658	phosphatidylserine metabolic process	"The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t002739003.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t002739003.1	biological_process	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t002739003.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	OMA
NV2t002739003.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	PANTHER
NV2t002739003.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t002739003.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002739003.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t002740001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t002740001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t002740001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t002740001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002740001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t002740001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t002741001.1	biological_process	GO:1990481	mRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]	PANTHER
NV2t002741001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t002742001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	InterPro
NV2t002742001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t002742001.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	OMA
NV2t002742001.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	PANTHER
NV2t002742001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t002742001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t002742001.1	molecular_function	GO:0004448	isocitrate dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: isocitrate + NAD(P)+ = 2-oxoglutarate + CO2 + NAD(P)H." [GOC:curators]	OMA
NV2t002742001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t002742001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t002742002.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	InterPro
NV2t002742002.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	PANTHER
NV2t002742002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t002745001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t002745001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t002745001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t002745001.1	biological_process	GO:0010632	regulation of epithelial cell migration	"Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t002745001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t002745001.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t002745001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t002745001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t002745001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t002745001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t002745001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t002745001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t002745001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t002745001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t002745001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t002745001.1	molecular_function	GO:0070008	serine-type exopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]	InterPro
NV2t002746001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t002746001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t002746002.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t002746002.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t002747001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t002747001.1	biological_process	GO:0050688	regulation of defense response to virus	"Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]	OMA
NV2t002747001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t002747001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	PANTHER
NV2t002747002.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	PANTHER
NV2t002748001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002748001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t002748002.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t002748002.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t002748002.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002748002.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t002748002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002748002.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t002748002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002748002.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t002748002.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t002748002.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t002748002.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t002748002.1	molecular_function	GO:0022884	macromolecule transmembrane transporter activity	"Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002748002.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t002748002.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t002748002.1	molecular_function	GO:0140318	protein transporter activity	"Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]	OMA
NV2t002748003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002748003.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t002749001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002751001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002751001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002751001.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	OMA
NV2t002751001.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	PANTHER
NV2t002752001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002752001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002753001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t002753002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t002753002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002753002.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	InterPro
NV2t002753002.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t002753003.1	biological_process	GO:0045332	phospholipid translocation	"The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]	OMA
NV2t002753003.1	biological_process	GO:0051050	positive regulation of transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t002753003.1	biological_process	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t002753003.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t002753003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t002753003.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t002753003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002753003.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t002753003.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t002753003.1	cellular_component	GO:1990351	transporter complex	"A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]	OMA
NV2t002753003.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t002753003.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t002753003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002753003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002753003.1	molecular_function	GO:0005548	phospholipid transporter activity	"Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732]	OMA
NV2t002753003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002753003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t002753003.1	molecular_function	GO:0140303	intramembrane lipid transporter activity	"Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084]	OMA
NV2t002753003.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	InterPro
NV2t002753003.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t002753004.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t002754001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002755001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002757001.1	biological_process	GO:0030641	regulation of cellular pH	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t002757001.1	cellular_component	GO:0033176	proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t002758002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002758003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002758004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002759001.1	biological_process	GO:0007389	pattern specification process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]	PANTHER
NV2t002759002.1	biological_process	GO:0007389	pattern specification process	"Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]	PANTHER
NV2t002760001.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	OMA
NV2t002760001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t002760001.1	cellular_component	GO:1990923	PET complex	"A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs." [PMID:26669262]	PANTHER
NV2t002760001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002760001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002760001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t002761001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002761001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t002761001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t002761001.1	molecular_function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate." [RHEA:14653]	OMA
NV2t002761001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002761001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t002769001.1	biological_process	GO:0000154	rRNA modification	"The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t002769001.1	biological_process	GO:0001522	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule." [GOC:hjd, GOC:mah]	OMA
NV2t002769001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t002769001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t002769001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002769001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t002769001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t002769001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t002769001.1	molecular_function	GO:0034513	box H/ACA snoRNA binding	"Binding to a box H/ACA small nucleolar RNA." [GOC:mah]	PANTHER
NV2t002770001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t002770001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t002770001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t002770001.1	biological_process	GO:0045089	positive regulation of innate immune response	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]	OMA
NV2t002770001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002770001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002770001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t002770001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t002770002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002771001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002777001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002777001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t002778001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	InterPro
NV2t002778001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	PANTHER
NV2t002779001.1	biological_process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	"Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai]	PANTHER
NV2t002779001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002779001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	InterPro
NV2t002780001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002784001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002784001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t002785001.1	molecular_function	GO:0004879	nuclear receptor activity	"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]	PANTHER
NV2t002785001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002785001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t002785002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t002785002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002785002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t002785003.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t002785003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002785003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t002788001.1	biological_process	GO:0017187	peptidyl-glutamic acid carboxylation	"The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]	InterPro
NV2t002788001.1	biological_process	GO:0017187	peptidyl-glutamic acid carboxylation	"The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]	OMA
NV2t002788001.1	molecular_function	GO:0008488	gamma-glutamyl carboxylase activity	"Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194]	OMA
NV2t002788001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t002788001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	PANTHER
NV2t002789001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t002789001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t002789001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	OMA
NV2t002790001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002790001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t002790001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t002790001.1	molecular_function	GO:0004568	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	OMA
NV2t002790001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002790001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t002790001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t002793001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t002793001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t002793001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t002793001.1	cellular_component	GO:0005736	RNA polymerase I complex	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t002793001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t002793001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002793001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t002793001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t002793001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t002794001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t002794001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t002794002.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t002794002.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t002794002.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t002794002.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t002794002.1	biological_process	GO:0006911	phagocytosis, engulfment	"The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149]	OMA
NV2t002794002.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t002794002.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t002794002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t002794002.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	OMA
NV2t002794002.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t002794002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002794002.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t002794002.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t002794002.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t002794002.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t002794002.1	cellular_component	GO:0045335	phagocytic vesicle	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002794002.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t002794002.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t002794003.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t002796001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t002796001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t002797001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002797001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t002799001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t002799001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002800001.1	biological_process	GO:0001894	tissue homeostasis	"A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]	OMA
NV2t002800001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	InterPro
NV2t002800001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t002800001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t002800001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t002800001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t002800001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t002800002.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	InterPro
NV2t002800002.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t002800002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t002800003.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	InterPro
NV2t002800003.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t002800003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t002801001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t002801001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002801002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002801003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002801004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002801005.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002803001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002806001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t002806001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002806001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t002806001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t002811001.1	biological_process	GO:0010948	negative regulation of cell cycle process	"Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t002811001.1	biological_process	GO:0046599	regulation of centriole replication	"Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]	OMA
NV2t002811001.1	biological_process	GO:0046600	negative regulation of centriole replication	"Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication." [GOC:ai]	InterPro
NV2t002811001.1	biological_process	GO:0051494	negative regulation of cytoskeleton organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	OMA
NV2t002811001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t002812001.1	biological_process	GO:0071526	semaphorin-plexin signaling pathway	"The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]	OMA
NV2t002812001.1	biological_process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	"Any semaphorin-plexin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]	PANTHER
NV2t002812001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t002812001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002813001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t002813001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002813001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002813002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002813002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002816001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t002816001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t002816001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t002816001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t002816001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t002817001.1	biological_process	GO:0007214	gamma-aminobutyric acid signaling pathway	"The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell." [GOC:mah]	OMA
NV2t002817001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002817001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	OMA
NV2t002817001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t002817001.1	molecular_function	GO:0004965	G protein-coupled GABA receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]	OMA
NV2t002817002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002817002.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t002818001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002818001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002818001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t002818001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t002819001.1	cellular_component	GO:0070916	inositol phosphoceramide synthase complex	"A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces)." [GOC:mah, PMID:19726565]	PANTHER
NV2t002821001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t002821001.1	biological_process	GO:0006584	catecholamine metabolic process	"The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]	OMA
NV2t002821001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t002821001.1	biological_process	GO:0042428	serotonin metabolic process	"The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]	OMA
NV2t002821001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002821001.1	molecular_function	GO:0031624	ubiquitin conjugating enzyme binding	"Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]	OMA
NV2t002821001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t002821001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t002822001.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	InterPro
NV2t002824002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002825001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002825001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002826001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t002826001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002826001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t002829001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t002829001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002829001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002830001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t002830001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002830001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002834001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t002834001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t002834001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t002834001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t002834001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	PANTHER
NV2t002834002.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t002834002.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	PANTHER
NV2t002836001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t002836001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t002836001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t002838001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t002838001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t002840001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t002841001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t002841001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002843001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t002844001.1	biological_process	GO:0090162	establishment of epithelial cell polarity	"The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t002844001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t002844001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t002844002.1	biological_process	GO:0090162	establishment of epithelial cell polarity	"The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t002844002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t002844002.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t002844003.1	biological_process	GO:0090162	establishment of epithelial cell polarity	"The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t002844003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t002844003.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t002846001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t002846001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t002854001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002855001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002864001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002865001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002865001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t002865001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t002865001.1	biological_process	GO:0006434	seryl-tRNA aminoacylation	"The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t002865001.1	biological_process	GO:0006434	seryl-tRNA aminoacylation	"The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	OMA
NV2t002865001.1	biological_process	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	OMA
NV2t002865001.1	biological_process	GO:0051093	negative regulation of developmental process	"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t002865001.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t002865001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002865001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t002865001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t002865001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t002865001.1	molecular_function	GO:0004828	serine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11]	OMA
NV2t002865001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002866001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t002866001.1	biological_process	GO:0007006	mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t002866001.1	biological_process	GO:0010823	obsolete negative regulation of mitochondrion organization	"OBSOLETE. Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	OMA
NV2t002866001.1	biological_process	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t002866001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002866001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t002866001.1	biological_process	GO:0072530	purine-containing compound transmembrane transport	"The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t002866001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t002866001.1	biological_process	GO:1990544	mitochondrial ATP transmembrane transport	"The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:18485069]	InterPro
NV2t002866001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t002866001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t002866001.1	molecular_function	GO:0005471	ATP:ADP antiporter activity	"Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1]	OMA
NV2t002867001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002867001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002867001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t002867001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002869001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002869001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t002869001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t002869001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002869001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t002869001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002869001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t002869001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002869001.1	molecular_function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis]	OMA
NV2t002870001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002870001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002870001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002872001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t002872001.1	biological_process	GO:1990575	mitochondrial L-ornithine transmembrane transport	"The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9237680]	PANTHER
NV2t002872001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t002872001.1	molecular_function	GO:0015174	basic amino acid transmembrane transporter activity	"Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002872001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002872001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t002872001.1	molecular_function	GO:0072349	modified amino acid transmembrane transporter activity	"Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah]	OMA
NV2t002872001.1	molecular_function	GO:1901702	salt transmembrane transporter activity	"Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t002873001.1	biological_process	GO:0006560	proline metabolic process	"The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t002873001.1	biological_process	GO:0006561	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	InterPro
NV2t002873001.1	biological_process	GO:0009084	glutamine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t002873001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t002873001.1	biological_process	GO:0055129	L-proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd]	PANTHER
NV2t002873001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t002873001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t002875001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t002875001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t002875001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t002875001.1	biological_process	GO:0014065	obsolete phosphatidylinositol 3-kinase signaling	"OBSOLETE. A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, PMID:22525052, Wikipedia:PI3K]	OMA
NV2t002875001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t002875001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t002875001.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	OMA
NV2t002875001.1	biological_process	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t002875001.1	biological_process	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	PANTHER
NV2t002875001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002875001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002875001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002875001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002875001.1	cellular_component	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t002875001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t002875001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t002875001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t002875001.1	molecular_function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	"Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]	OMA
NV2t002875002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t002875002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t002875002.1	biological_process	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	PANTHER
NV2t002875003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t002875003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t002875003.1	biological_process	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	PANTHER
NV2t002875003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002876001.1	biological_process	GO:0009611	response to wounding	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]	InterPro
NV2t002878001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002878001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002878001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t002878001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002879001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002879001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002880001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002880001.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	PANTHER
NV2t002880002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002880002.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	PANTHER
NV2t002880003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002880003.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	PANTHER
NV2t002880004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002880004.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	PANTHER
NV2t002880005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002880005.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	PANTHER
NV2t002880006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002880006.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	PANTHER
NV2t002880007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002880007.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	PANTHER
NV2t002882001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002882002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002884001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t002884001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t002884001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t002884001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t002884001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002884001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t002884001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t002886001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t002886001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	PANTHER
NV2t002887001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002887001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002887002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002887002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002892001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t002892001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t002892001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t002892001.1	biological_process	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	OMA
NV2t002892001.1	biological_process	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]	OMA
NV2t002892001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t002892001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t002892001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002893001.1	biological_process	GO:0071569	protein ufmylation	"Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]	InterPro
NV2t002893001.1	biological_process	GO:1990592	protein K69-linked ufmylation	"A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498]	PANTHER
NV2t002894001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	OMA
NV2t002894001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t002894001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t002894001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t002894001.1	biological_process	GO:0071569	protein ufmylation	"Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]	InterPro
NV2t002894001.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t002894001.1	biological_process	GO:1990592	protein K69-linked ufmylation	"A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498]	PANTHER
NV2t002894001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002894001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002894002.1	biological_process	GO:0071569	protein ufmylation	"Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]	InterPro
NV2t002894002.1	biological_process	GO:1990592	protein K69-linked ufmylation	"A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498]	PANTHER
NV2t002895001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t002895001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t002895001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t002895001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002895001.1	biological_process	GO:0009190	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002895001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002895001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t002895001.1	biological_process	GO:0046058	cAMP metabolic process	"The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators]	OMA
NV2t002895001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002895001.1	molecular_function	GO:0004016	adenylate cyclase activity	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]	OMA
NV2t002899001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t002899001.1	biological_process	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t002899001.1	biological_process	GO:0007080	mitotic metaphase chromosome alignment	"A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [ISBN:0815316194]	OMA
NV2t002899001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t002899001.1	biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]	OMA
NV2t002899001.1	biological_process	GO:0019217	regulation of fatty acid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]	OMA
NV2t002899001.1	biological_process	GO:0031327	negative regulation of cellular biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t002899001.1	biological_process	GO:0032147	activation of protein kinase activity	"Any process that initiates the activity of an inactive protein kinase." [GOC:mah]	OMA
NV2t002899001.1	biological_process	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	"Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]	OMA
NV2t002899001.1	biological_process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]	OMA
NV2t002899001.1	biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]	OMA
NV2t002899001.1	biological_process	GO:0051055	negative regulation of lipid biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	OMA
NV2t002899001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t002899001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002899001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	OMA
NV2t002899001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	OMA
NV2t002899001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t002899001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t002899001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002899001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t002899001.1	molecular_function	GO:0005126	cytokine receptor binding	"Binding to a cytokine receptor." [GOC:mah, GOC:vw]	OMA
NV2t002899001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	OMA
NV2t002900001.1	biological_process	GO:0001736	establishment of planar polarity	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]	OMA
NV2t002900001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t002900001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t002900001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t002900001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t002900001.1	biological_process	GO:0035107	appendage morphogenesis	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]	OMA
NV2t002900001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t002900001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002900001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002900001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t002900001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002900002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t002900002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002900002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002900003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t002900003.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002900003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002900004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t002900004.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t002900004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002902001.1	biological_process	GO:0006878	intracellular copper ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t002902001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t002902001.1	biological_process	GO:0015677	copper ion import	"The directed movement of copper ions into a cell or organelle." [GOC:ai]	OMA
NV2t002902001.1	biological_process	GO:0022404	molting cycle process	"A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete]	OMA
NV2t002902001.1	biological_process	GO:0043473	pigmentation	"The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl]	OMA
NV2t002902001.1	biological_process	GO:0046688	response to copper ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai]	OMA
NV2t002902001.1	biological_process	GO:0055070	copper ion homeostasis	"Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	PANTHER
NV2t002902001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t002902001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002902001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t002902001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t002902001.1	molecular_function	GO:0005375	copper ion transmembrane transporter activity	"Enables the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t002902001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t002902001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t002902001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002902001.1	molecular_function	GO:0015662	P-type ion transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	OMA
NV2t002902001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002902001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t002902001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t002902001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	OMA
NV2t002902001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t002902001.1	molecular_function	GO:1901682	sulfur compound transmembrane transporter activity	"Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t002902001.1	molecular_function	GO:1901702	salt transmembrane transporter activity	"Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t002903001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t002903001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t002903001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t002903001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002908001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002908001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002908001.1	biological_process	GO:0038060	nitric oxide-cGMP-mediated signaling	"An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632]	OMA
NV2t002908001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	OMA
NV2t002908001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002908001.1	biological_process	GO:0071241	cellular response to inorganic substance	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah]	OMA
NV2t002908001.1	biological_process	GO:0071731	response to nitric oxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf]	OMA
NV2t002908001.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t002908001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t002908001.1	cellular_component	GO:0008074	guanylate cyclase complex, soluble	"Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]	OMA
NV2t002908001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t002908001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t002908001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002908001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t002910001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002910001.1	biological_process	GO:0019934	cGMP-mediated signaling	"An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling]	OMA
NV2t002910001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002910001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	OMA
NV2t002910001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002910001.1	cellular_component	GO:0008074	guanylate cyclase complex, soluble	"Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]	OMA
NV2t002910001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t002910001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002910001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t002911001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002911001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002911001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002911001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002912001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002912001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002912001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002912001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002912002.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002912002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002912002.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002912002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002912003.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002912003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002912003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t002912003.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002912003.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t002912003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002912003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t002912004.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002912004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002912004.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002912004.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002912005.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002912005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002912005.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002912005.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002912006.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t002912006.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t002912006.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t002912006.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t002913001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t002913002.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t002913002.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	OMA
NV2t002913002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t002913002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002916001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002916001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t002916001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t002916001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t002916001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t002916001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002916002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002916002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t002916002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002921001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002921001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t002921001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t002921001.1	biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	"The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t002921001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	PANTHER
NV2t002921001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t002921001.1	biological_process	GO:0009719	response to endogenous stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]	OMA
NV2t002921001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t002921001.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t002921001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t002921001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t002921001.1	biological_process	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t002921001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	OMA
NV2t002921001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t002921001.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t002921001.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t002921001.1	biological_process	GO:0048534	hematopoietic or lymphoid organ development	"The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149]	OMA
NV2t002921001.1	biological_process	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	OMA
NV2t002921001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t002921001.1	biological_process	GO:0070371	ERK1 and ERK2 cascade	"A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development." [PMID:20811974, PMID:23125017, PMID:28903453]	OMA
NV2t002921001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002921001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002921001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t002921001.1	molecular_function	GO:0004709	MAP kinase kinase kinase activity	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]	OMA
NV2t002921001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002921001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002921001.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	OMA
NV2t002923001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002923001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002923001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t002923001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	PANTHER
NV2t002925001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002926001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002926001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002927001.1	biological_process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [GOC:al, GOC:vw]	OMA
NV2t002927001.1	molecular_function	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:hb, RHEA:17193]	PANTHER
NV2t002927001.1	molecular_function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]	OMA
NV2t002927001.1	molecular_function	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	"Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah]	OMA
NV2t002928001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002928001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002928001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t002928001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t002930001.1	biological_process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]	OMA
NV2t002930001.1	biological_process	GO:0003143	embryonic heart tube morphogenesis	"The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]	OMA
NV2t002930001.1	biological_process	GO:0007259	cell surface receptor signaling pathway via JAK-STAT	"A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins." [PMID:12039028]	OMA
NV2t002930001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t002930001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t002930001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t002930001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	OMA
NV2t002930001.1	biological_process	GO:0042994	cytoplasmic sequestering of transcription factor	"The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]	OMA
NV2t002930001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	OMA
NV2t002930001.1	biological_process	GO:0045429	positive regulation of nitric oxide biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]	OMA
NV2t002930001.1	biological_process	GO:0045787	positive regulation of cell cycle	"Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]	OMA
NV2t002930001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002930001.1	biological_process	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	OMA
NV2t002930001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	OMA
NV2t002930001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t002930001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t002930001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t002930001.1	biological_process	GO:0061333	renal tubule morphogenesis	"The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10]	OMA
NV2t002930001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t002930001.1	biological_process	GO:0071320	cellular response to cAMP	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah]	OMA
NV2t002930001.1	biological_process	GO:0071462	cellular response to water stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah]	OMA
NV2t002930001.1	biological_process	GO:0071470	cellular response to osmotic stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]	OMA
NV2t002930001.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t002930001.1	biological_process	GO:0090279	regulation of calcium ion import	"Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]	OMA
NV2t002930001.1	biological_process	GO:0198738	obsolete cell-cell signaling by wnt	"OBSOLETE. Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell." [GOC:dos]	OMA
NV2t002930001.1	biological_process	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	"Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]	OMA
NV2t002930001.1	biological_process	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	"Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]	OMA
NV2t002930001.1	biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t002930001.1	biological_process	GO:2001258	negative regulation of cation channel activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity." [GOC:BHF]	OMA
NV2t002930001.1	biological_process	GO:2001259	positive regulation of cation channel activity	"Any process that activates or increases the frequency, rate or extent of cation channel activity." [GOC:BHF]	OMA
NV2t002930001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002930001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t002930001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t002930001.1	cellular_component	GO:0009925	basal plasma membrane	"The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t002930001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002930001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t002930001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t002930001.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t002930001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t002930001.1	cellular_component	GO:0045180	basal cortex	"The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf]	OMA
NV2t002930001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t002930001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t002930001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t002930001.1	molecular_function	GO:0005245	voltage-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]	OMA
NV2t002930001.1	molecular_function	GO:0005248	voltage-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002930001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002930001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002930001.1	molecular_function	GO:0015271	outward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]	OMA
NV2t002930001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t002930001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t002930001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t002930001.1	molecular_function	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	OMA
NV2t002930001.1	molecular_function	GO:0048763	calcium-induced calcium release activity	"Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration." [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752]	OMA
NV2t002930001.1	molecular_function	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	OMA
NV2t002930001.1	molecular_function	GO:0051371	muscle alpha-actinin binding	"Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165]	OMA
NV2t002930002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002932001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002932001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	InterPro
NV2t002932001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t002933001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t002933001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t002933001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002933001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t002933001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002933001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t002933001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	OMA
NV2t002933002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t002933002.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002934001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002934001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	InterPro
NV2t002934001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t002934001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t002936001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t002936001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002936001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002937001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002937001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002937001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002939001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	PANTHER
NV2t002939001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002940001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	PANTHER
NV2t002940001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002941001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002941001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002941001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t002944001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002947001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t002947001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002952001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002952001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002953001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002953001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t002954001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t002954001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t002954001.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t002954001.1	molecular_function	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	"Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]." [RHEA:24052]	OMA
NV2t002954001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t002954001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t002954002.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t002955001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t002955001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002956001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t002956001.1	cellular_component	GO:0071014	post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]	PANTHER
NV2t002956001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t002956001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t002956002.1	cellular_component	GO:0071014	post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]	PANTHER
NV2t002957001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t002957001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t002957001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002957001.1	molecular_function	GO:0043047	single-stranded telomeric DNA binding	"Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]	InterPro
NV2t002957001.1	molecular_function	GO:0043047	single-stranded telomeric DNA binding	"Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]	OMA
NV2t002957001.1	molecular_function	GO:0098505	G-rich strand telomeric DNA binding	"Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150]	PANTHER
NV2t002957002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002957002.1	molecular_function	GO:0043047	single-stranded telomeric DNA binding	"Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]	InterPro
NV2t002957002.1	molecular_function	GO:0098505	G-rich strand telomeric DNA binding	"Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150]	PANTHER
NV2t002958001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002958001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002959001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002959001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t002963001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002963001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t002963001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002963001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002963001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002964001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t002964001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t002964001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t002964001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t002964001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002965001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002965001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t002966001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002966001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002966001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t002966001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002966001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t002966002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002966002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002966002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002966003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002966003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002966003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002966004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002966004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t002966004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t002971001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t002971001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t002971001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t002971001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002971001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002972001.1	biological_process	GO:0050906	detection of stimulus involved in sensory perception	"The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]	InterPro
NV2t002972001.1	biological_process	GO:0050906	detection of stimulus involved in sensory perception	"The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]	OMA
NV2t002972001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t002972001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t002972001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t002972001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002972001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t002972001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002972001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t002972001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t002972002.1	biological_process	GO:0050906	detection of stimulus involved in sensory perception	"The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]	InterPro
NV2t002972002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t002972002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002972002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t002973001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t002973001.1	molecular_function	GO:0042283	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	"Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927]	PANTHER
NV2t002973002.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	OMA
NV2t002973002.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t002973002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t002973002.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	OMA
NV2t002973002.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t002973002.1	molecular_function	GO:0042283	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	"Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927]	PANTHER
NV2t002973002.1	molecular_function	GO:0046527	glucosyltransferase activity	"Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	OMA
NV2t002974001.1	biological_process	GO:0006275	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	OMA
NV2t002974001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	InterPro
NV2t002974001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t002974001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t002974002.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	InterPro
NV2t002977001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t002977001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t002977001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t002977001.1	cellular_component	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	PANTHER
NV2t002977001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002978001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t002978001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t002978001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t002980001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t002980001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t002980001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002980001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t002983001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002983001.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	PANTHER
NV2t002983002.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	PANTHER
NV2t002983003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002983003.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	PANTHER
NV2t002985001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002985001.1	biological_process	GO:0009156	ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t002985001.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	InterPro
NV2t002985001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	InterPro
NV2t002985001.1	biological_process	GO:0046390	ribose phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	OMA
NV2t002985001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002985001.1	cellular_component	GO:0061695	transferase complex, transferring phosphorus-containing groups	"A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph]	OMA
NV2t002985001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t002985001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t002985001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t002985002.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	InterPro
NV2t002985002.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	InterPro
NV2t002986001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t002987001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002987002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002987003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002988001.1	biological_process	GO:0000706	meiotic DNA double-strand break processing	"The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324]	OMA
NV2t002988001.1	biological_process	GO:0000712	resolution of meiotic recombination intermediates	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]	OMA
NV2t002988001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t002988001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t002988001.1	cellular_component	GO:0033557	Slx1-Slx4 complex	"A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]	InterPro
NV2t002988001.1	cellular_component	GO:0033557	Slx1-Slx4 complex	"A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]	OMA
NV2t002988001.1	cellular_component	GO:0033557	Slx1-Slx4 complex	"A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]	PANTHER
NV2t002988001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t002988001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t002990001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002990001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t002990001.1	biological_process	GO:0006044	N-acetylglucosamine metabolic process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]	InterPro
NV2t002990001.1	biological_process	GO:0006044	N-acetylglucosamine metabolic process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]	OMA
NV2t002990001.1	biological_process	GO:0006091	generation of precursor metabolites and energy	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]	OMA
NV2t002990001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t002990001.1	biological_process	GO:0046395	carboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t002990001.1	biological_process	GO:1901072	glucosamine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie]	OMA
NV2t002990001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t002990001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t002990001.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	OMA
NV2t002990001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t002990001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	PANTHER
NV2t002990002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t002990002.1	biological_process	GO:0006044	N-acetylglucosamine metabolic process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]	InterPro
NV2t002990002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	PANTHER
NV2t002994001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002994001.1	biological_process	GO:0086011	membrane repolarization during action potential	"The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t002994001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002994001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002994001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002995001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002995001.1	biological_process	GO:0086011	membrane repolarization during action potential	"The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t002995001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002995001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t002995001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t002995002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002995002.1	biological_process	GO:0086011	membrane repolarization during action potential	"The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t002995002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002996001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t002996001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t002996001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t002996001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002996001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002996001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t002997001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t002997001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002997001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t002998001.1	biological_process	GO:0001508	action potential	"A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]	OMA
NV2t002998001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t002998001.1	biological_process	GO:0086011	membrane repolarization during action potential	"The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t002998001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t002998001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t002998001.1	molecular_function	GO:0005242	inward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]	OMA
NV2t003001001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003001001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003001001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t003002001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t003002001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t003002001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	PANTHER
NV2t003002001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t003002001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003002001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t003002001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003003001.1	cellular_component	GO:0071546	pi-body	"A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505]	PANTHER
NV2t003003001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003003002.1	cellular_component	GO:0071546	pi-body	"A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505]	PANTHER
NV2t003003002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003003003.1	cellular_component	GO:0071546	pi-body	"A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505]	PANTHER
NV2t003003003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003003004.1	cellular_component	GO:0071546	pi-body	"A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505]	PANTHER
NV2t003003004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003004001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t003004001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t003004001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t003004002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t003006001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	OMA
NV2t003006001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	PANTHER
NV2t003006001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003006002.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	PANTHER
NV2t003006003.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	PANTHER
NV2t003007001.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	OMA
NV2t003007001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t003007001.1	biological_process	GO:0046164	alcohol catabolic process	"The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]	OMA
NV2t003007001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t003007001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t003007001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t003007001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t003007001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t003007001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t003007001.1	molecular_function	GO:0033781	cholesterol 24-hydroxylase activity	"Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]	PANTHER
NV2t003008001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t003008002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t003008002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t003008002.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t003008002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t003009001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003009001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009003.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009004.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009005.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009006.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009007.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009008.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003009010.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003009010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003013001.1	biological_process	GO:0035442	dipeptide transmembrane transport	"The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:vw]	OMA
NV2t003013001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003013001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t003013001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003013001.1	molecular_function	GO:0035673	oligopeptide transmembrane transporter activity	"Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732]	OMA
NV2t003017001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t003017001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003018001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t003019001.1	molecular_function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341]	InterPro
NV2t003019001.1	molecular_function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341]	OMA
NV2t003019001.1	molecular_function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341]	PANTHER
NV2t003022001.1	biological_process	GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343]	PANTHER
NV2t003022001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t003023001.1	biological_process	GO:0006553	lysine metabolic process	"The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]	OMA
NV2t003023001.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t003023001.1	biological_process	GO:0019878	lysine biosynthetic process via aminoadipic acid	"The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators]	PANTHER
NV2t003023001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t003023001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003023001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t003023001.1	molecular_function	GO:0008897	holo-[acyl-carrier-protein] synthase activity	"Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]	InterPro
NV2t003023001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t003024001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t003024001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t003024001.1	biological_process	GO:0070124	mitochondrial translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah]	PANTHER
NV2t003024001.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t003024001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t003024001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t003024001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t003026001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003026001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003026001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t003026001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t003026001.1	molecular_function	GO:0033293	monocarboxylic acid binding	"Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah]	OMA
NV2t003026001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t003026001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t003026001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t003028001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003028001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003029001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003030001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003030001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003031001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t003031001.1	cellular_component	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	"A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838]	PANTHER
NV2t003031001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003034001.1	biological_process	GO:0061511	centriole elongation	"The centrosome organization process by which a centriole increases in length as part of the process of replication." [GOC:dph, PMID:21576394]	PANTHER
NV2t003035001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003035001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003035001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003036001.1	biological_process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	PANTHER
NV2t003037001.1	molecular_function	GO:0015175	neutral L-amino acid transmembrane transporter activity	"Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003037001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003037001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003039001.1	molecular_function	GO:0005416	amino acid:monoatomic cation symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]	OMA
NV2t003039001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t003039001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003039001.1	molecular_function	GO:0015187	glycine transmembrane transporter activity	"Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai]	OMA
NV2t003040001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003040001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003042001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003042002.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003042003.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003042004.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003042005.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003044001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003045001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t003045001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	OMA
NV2t003045001.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	InterPro
NV2t003045001.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	OMA
NV2t003045001.1	molecular_function	GO:0004044	amidophosphoribosyltransferase activity	"Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O." [EC:2.4.2.14, RHEA:14905]	OMA
NV2t003045002.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t003045002.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	InterPro
NV2t003045003.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t003045003.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	InterPro
NV2t003045004.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t003045004.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	InterPro
NV2t003045005.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t003045005.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	InterPro
NV2t003046001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t003046001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	InterPro
NV2t003046001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	OMA
NV2t003046001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	PANTHER
NV2t003046001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003046001.1	molecular_function	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	"Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate." [EC:6.3.2.6, RHEA:22628]	OMA
NV2t003046001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t003046001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t003047001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003047001.1	molecular_function	GO:0031177	phosphopantetheine binding	"Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw]	InterPro
NV2t003047002.1	molecular_function	GO:0031177	phosphopantetheine binding	"Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw]	InterPro
NV2t003047003.1	biological_process	GO:0030497	fatty acid elongation	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]	PANTHER
NV2t003047003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003047004.1	biological_process	GO:0030497	fatty acid elongation	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]	PANTHER
NV2t003047004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003047004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t003047005.1	biological_process	GO:0030497	fatty acid elongation	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]	PANTHER
NV2t003047005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003048001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003048001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003048001.1	molecular_function	GO:0015095	magnesium ion transmembrane transporter activity	"Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t003049001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003050002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t003050002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t003050002.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t003051001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t003051001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t003053001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003053001.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003053002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003053002.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003053003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003053003.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003053004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003053004.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003057001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t003057001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	PANTHER
NV2t003057001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003057001.1	molecular_function	GO:0015038	glutathione disulfide oxidoreductase activity	"Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah]	OMA
NV2t003057001.1	molecular_function	GO:0016209	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	OMA
NV2t003057002.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	PANTHER
NV2t003061001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t003061001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003062001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t003062001.1	biological_process	GO:0050709	negative regulation of protein secretion	"Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	OMA
NV2t003062001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003062001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003062001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t003063001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t003063001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003063001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003063001.1	molecular_function	GO:0008514	organic anion transmembrane transporter activity	"Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t003063001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003063001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t003063001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t003064001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003064001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t003064001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003064002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003064002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t003064002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003064003.1	biological_process	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	OMA
NV2t003064003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t003064003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t003064003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003064003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003064003.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t003064003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t003064003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003064003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t003064004.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t003064004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003065001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t003065001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003065001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003071001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t003073001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t003073001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003073001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t003073001.1	molecular_function	GO:0051723	protein methylesterase activity	"Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai]	InterPro
NV2t003073001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t003073001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t003074001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t003074001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t003074001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003074001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t003075001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t003075001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t003075001.1	biological_process	GO:0007000	nucleolus organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]	OMA
NV2t003075001.1	biological_process	GO:0034085	establishment of sister chromatid cohesion	"The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase." [GOC:jh, GOC:mah, PMID:14623866]	OMA
NV2t003075001.1	biological_process	GO:0034085	establishment of sister chromatid cohesion	"The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase." [GOC:jh, GOC:mah, PMID:14623866]	PANTHER
NV2t003075001.1	biological_process	GO:0045005	DNA-templated DNA replication maintenance of fidelity	"A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw]	OMA
NV2t003075001.1	biological_process	GO:1901836	regulation of transcription of nucleolar large rRNA by RNA polymerase I	"Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie]	OMA
NV2t003075001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t003075001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003075001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003075001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	InterPro
NV2t003075001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t003075001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003075001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003075001.1	molecular_function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	InterPro
NV2t003075001.1	molecular_function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	OMA
NV2t003076001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t003076001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t003078001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003078001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003078001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003080001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003081001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003081001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003081001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t003081001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t003081001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003081001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003086001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t003086001.1	biological_process	GO:0072337	modified amino acid transport	"The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t003086001.1	biological_process	GO:1902603	carnitine transmembrane transport	"The directed movement of carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t003086001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t003086001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t003086001.1	molecular_function	GO:0015651	quaternary ammonium group transmembrane transporter activity	"Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732]	OMA
NV2t003092001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t003092001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t003092001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t003092001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t003092001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t003092001.1	biological_process	GO:0022409	positive regulation of cell-cell adhesion	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t003092001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t003092001.1	biological_process	GO:0031623	receptor internalization	"A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]	OMA
NV2t003092001.1	biological_process	GO:0045088	regulation of innate immune response	"Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]	OMA
NV2t003092001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t003092001.1	biological_process	GO:0050680	negative regulation of epithelial cell proliferation	"Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai]	OMA
NV2t003092001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t003092001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t003092001.1	biological_process	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	OMA
NV2t003092001.1	biological_process	GO:0061099	negative regulation of protein tyrosine kinase activity	"Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]	OMA
NV2t003092001.1	biological_process	GO:0070836	caveola assembly	"The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane." [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858]	InterPro
NV2t003092001.1	biological_process	GO:0071709	membrane assembly	"The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]	OMA
NV2t003092001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t003092001.1	biological_process	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	OMA
NV2t003092001.1	biological_process	GO:0090287	regulation of cellular response to growth factor stimulus	"Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]	OMA
NV2t003092001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t003092001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t003092001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t003092001.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t003092001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t003092001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t003092001.1	cellular_component	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	OMA
NV2t003092001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t003092001.1	molecular_function	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	OMA
NV2t003092001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t003093001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t003094001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t003094001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t003094001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003094001.1	molecular_function	GO:0001729	ceramide kinase activity	"Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138]	OMA
NV2t003094001.1	molecular_function	GO:0004143	ATP-dependent diacylglycerol kinase activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+." [GOC:elh, RHEA:10272]	OMA
NV2t003094001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t003094001.1	molecular_function	GO:0047620	acylglycerol kinase activity	"Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN]	PANTHER
NV2t003095001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003095001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003095001.1	biological_process	GO:0007417	central nervous system development	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]	OMA
NV2t003095001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t003095001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003095001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t003095001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003095001.1	molecular_function	GO:0008240	tripeptidyl-peptidase activity	"Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]	OMA
NV2t003095001.1	molecular_function	GO:0008240	tripeptidyl-peptidase activity	"Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]	PANTHER
NV2t003096001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t003096001.1	biological_process	GO:0046015	regulation of transcription by glucose	"Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]	PANTHER
NV2t003096001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003096001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t003096001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t003096001.1	molecular_function	GO:0016433	rRNA (adenine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators]	OMA
NV2t003096002.1	biological_process	GO:0046015	regulation of transcription by glucose	"Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]	PANTHER
NV2t003096002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t003097001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t003097001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t003097001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003097001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t003097001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t003097001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t003098001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003098001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003098001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t003098001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t003098001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003100001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003100001.1	biological_process	GO:0009953	dorsal/ventral pattern formation	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t003100001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t003100001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003100001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003100001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	InterPro
NV2t003100001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t003100001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003100001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003100001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003100001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003100001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003102001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003102001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t003102001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t003103001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t003103001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t003103001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003103001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t003103001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t003104001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t003105001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003105001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t003107001.1	biological_process	GO:0001964	startle response	"An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]	OMA
NV2t003107001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t003107001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t003107001.1	biological_process	GO:0031290	retinal ganglion cell axon guidance	"The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]	OMA
NV2t003107001.1	biological_process	GO:0048592	eye morphogenesis	"The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t003107001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t003107001.1	biological_process	GO:0097202	activation of cysteine-type endopeptidase activity	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:21726810]	OMA
NV2t003107001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t003107001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t003108001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t003108001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t003108001.1	biological_process	GO:1903320	regulation of protein modification by small protein conjugation or removal	"Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t003108001.1	biological_process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	"Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]	OMA
NV2t003108001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003108001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t003108001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t003108001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003108001.1	molecular_function	GO:0035800	deubiquitinase activator activity	"Binds to and increases the activity of a deubiquitinase." [GOC:sart, ISBN:0120793709]	OMA
NV2t003108001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t003108001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t003109001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003112001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003112001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t003112002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003112002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003112002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003112002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003112002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t003112002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t003112003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003112003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003112003.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t003115001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t003115001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003115001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003115001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t003115001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t003116001.1	biological_process	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	OMA
NV2t003116001.1	biological_process	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	PANTHER
NV2t003116001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t003117001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003117001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t003118001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t003118001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t003118001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	OMA
NV2t003118001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	OMA
NV2t003118001.1	biological_process	GO:0097500	receptor localization to non-motile cilium	"A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium." [GOC:cilia, GOC:kmv, PMID:23128241]	PANTHER
NV2t003118001.1	biological_process	GO:1990778	protein localization to cell periphery	"A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]	OMA
NV2t003118001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t003118001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t003119001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t003119001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t003119001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t003119001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t003119001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003119001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003119001.1	cellular_component	GO:0098839	postsynaptic density membrane	"The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos]	OMA
NV2t003119001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t003119001.1	molecular_function	GO:0005388	P-type calcium transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)." [RHEA:18105]	InterPro
NV2t003119001.1	molecular_function	GO:0005388	P-type calcium transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)." [RHEA:18105]	OMA
NV2t003119001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003119001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003119001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003119001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t003119001.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	OMA
NV2t003120001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t003120001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t003120001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003120001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t003120001.1	molecular_function	GO:0005388	P-type calcium transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)." [RHEA:18105]	OMA
NV2t003120001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003120001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003120001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t003123001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003123001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003124001.1	biological_process	GO:0006720	isoprenoid metabolic process	"The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684]	OMA
NV2t003124001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t003124001.1	biological_process	GO:0019395	fatty acid oxidation	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t003124001.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t003124001.1	biological_process	GO:0097089	methyl-branched fatty acid metabolic process	"The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain." [GOC:rs, PMID:19933331]	OMA
NV2t003124001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t003124001.1	cellular_component	GO:0097731	9+0 non-motile cilium	"A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:22118931]	OMA
NV2t003124001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t003124001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t003124001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t003124001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t003124001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t003124001.1	molecular_function	GO:0048244	phytanoyl-CoA dioxygenase activity	"Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate." [EC:1.14.11.18, RHEA:16065]	InterPro
NV2t003124001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t003124001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t003128001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t003128001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t003128001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	OMA
NV2t003129001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t003129001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t003129001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	OMA
NV2t003130001.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t003130002.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t003130003.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t003130004.1	biological_process	GO:0006998	nuclear envelope organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]	OMA
NV2t003130004.1	biological_process	GO:0030514	negative regulation of BMP signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]	OMA
NV2t003130004.1	biological_process	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t003130004.1	cellular_component	GO:0005637	nuclear inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]	OMA
NV2t003130004.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	OMA
NV2t003130004.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t003130005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003130005.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t003130006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003130006.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t003130007.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t003131001.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t003131001.1	biological_process	GO:0042572	retinol metabolic process	"The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]	OMA
NV2t003131001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003131001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003131001.1	molecular_function	GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	"Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [RHEA:21284]	OMA
NV2t003131001.1	molecular_function	GO:0016229	steroid dehydrogenase activity	"Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]	OMA
NV2t003131001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003135001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t003135001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003135002.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t003135002.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	OMA
NV2t003135002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t003135002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t003135002.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t003135002.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t003135002.1	biological_process	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	OMA
NV2t003135002.1	biological_process	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	OMA
NV2t003135002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003135002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003135002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003135002.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t003135002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003135002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003136001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003136001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t003136002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003136002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t003136002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003136003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003136003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t003136004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003136004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t003136004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003137001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003137001.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	PANTHER
NV2t003137002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003137002.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	PANTHER
NV2t003137003.1	biological_process	GO:0007517	muscle organ development	"The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732]	OMA
NV2t003137003.1	cellular_component	GO:0016011	dystroglycan complex	"A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609]	OMA
NV2t003137003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003137003.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t003137003.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	PANTHER
NV2t003137003.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t003137004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003137004.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	PANTHER
NV2t003139001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003143001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t003143001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t003143001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003143002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t003143002.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t003143002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003143003.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t003143003.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t003143003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003144001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t003144001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003144001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003145001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t003145001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t003145001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t003145001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003145001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t003145001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t003145001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t003145001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t003146001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003146001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003146001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t003146001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t003146001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003146002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003146002.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t003146002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003147001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t003147001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003147001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t003148001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t003148001.1	biological_process	GO:0006427	histidyl-tRNA aminoacylation	"The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t003148001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t003148001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t003148001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t003148001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003148001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t003148001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003148001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t003149001.1	biological_process	GO:0001508	action potential	"A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]	OMA
NV2t003149001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003149001.1	biological_process	GO:0086011	membrane repolarization during action potential	"The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t003149001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003149001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003149001.1	molecular_function	GO:0005242	inward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]	OMA
NV2t003150001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003150001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003150001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t003150001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t003150001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003150001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003151001.1	molecular_function	GO:0043515	kinetochore binding	"Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl]	PANTHER
NV2t003155001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003155002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003157001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t003157001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003161001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t003161001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t003161001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t003163001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003165001.1	biological_process	GO:0006812	monoatomic cation transport	"The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t003165001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003165001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t003165001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003165001.1	molecular_function	GO:0005227	calcium-activated cation channel activity	"Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	OMA
NV2t003166001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t003166001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003166001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003166001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t003168001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003168001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003168002.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t003168002.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t003168002.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t003168002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003168002.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t003168002.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t003168002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003168002.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t003168002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t003168002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003168002.1	biological_process	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	OMA
NV2t003168002.1	biological_process	GO:0061351	neural precursor cell proliferation	"The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf]	OMA
NV2t003168002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003168002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003168002.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t003168002.1	cellular_component	GO:0019897	extrinsic component of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]	OMA
NV2t003168002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t003168002.1	molecular_function	GO:0005109	frizzled binding	"Binding to a frizzled (fz) receptor." [GOC:ceb]	OMA
NV2t003168002.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t003168003.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003168003.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003170001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t003170001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003170001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t003171001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t003171001.1	biological_process	GO:0048280	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	PANTHER
NV2t003171001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003173001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003173001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003174001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003175001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t003175001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t003175001.1	biological_process	GO:0090110	COPII-coated vesicle cargo loading	"The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]	PANTHER
NV2t003175001.1	cellular_component	GO:0030120	vesicle coat	"A membrane coat found on a coated vesicle." [GOC:mah]	OMA
NV2t003175001.1	cellular_component	GO:0030127	COPII vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]	InterPro
NV2t003175001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t003175001.1	cellular_component	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	OMA
NV2t003175001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003175002.1	biological_process	GO:0090110	COPII-coated vesicle cargo loading	"The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]	PANTHER
NV2t003175002.1	cellular_component	GO:0030127	COPII vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]	InterPro
NV2t003176001.1	biological_process	GO:0010948	negative regulation of cell cycle process	"Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t003176001.1	biological_process	GO:0046599	regulation of centriole replication	"Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]	OMA
NV2t003176001.1	biological_process	GO:0046600	negative regulation of centriole replication	"Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication." [GOC:ai]	InterPro
NV2t003176001.1	biological_process	GO:0051494	negative regulation of cytoskeleton organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	OMA
NV2t003176001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t003177001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	PANTHER
NV2t003177003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003177003.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	PANTHER
NV2t003180007.1	biological_process	GO:0090503	obsolete RNA phosphodiester bond hydrolysis, exonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	PANTHER
NV2t003181001.1	cellular_component	GO:0044614	nuclear pore cytoplasmic filaments	"Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t003181001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t003181002.1	cellular_component	GO:0044614	nuclear pore cytoplasmic filaments	"Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t003181002.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t003182001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t003182001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t003182001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t003182001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003184001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003185001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t003185001.1	cellular_component	GO:0034245	mitochondrial DNA-directed RNA polymerase complex	"A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382]	PANTHER
NV2t003185001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003186001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003186001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t003187001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003187002.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t003187002.1	biological_process	GO:0036158	outer dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t003187002.1	biological_process	GO:0036159	inner dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t003187002.1	biological_process	GO:0044458	motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]	OMA
NV2t003187002.1	biological_process	GO:0045724	positive regulation of cilium assembly	"Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]	OMA
NV2t003187002.1	biological_process	GO:1905503	regulation of motile cilium assembly	"Any process that modulates the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941]	OMA
NV2t003187002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003187002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003187002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t003187002.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t003187002.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t003187003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003189001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003189001.1	biological_process	GO:0032392	DNA geometric change	"The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah]	OMA
NV2t003189001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003189001.1	molecular_function	GO:0000400	four-way junction DNA binding	"Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]	OMA
NV2t003189001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t003189001.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	OMA
NV2t003189001.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	PANTHER
NV2t003189002.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	PANTHER
NV2t003190001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t003190001.1	biological_process	GO:0045930	negative regulation of mitotic cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t003190001.1	biological_process	GO:0045930	negative regulation of mitotic cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t003190001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003190001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003192001.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t003192001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003192001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003193001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	InterPro
NV2t003193001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t003194001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t003194001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t003194001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t003194001.1	biological_process	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t003194001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t003194001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t003194001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003194001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003194001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t003194001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t003194001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003194001.1	molecular_function	GO:0016018	cyclosporin A binding	"Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb]	OMA
NV2t003194001.1	molecular_function	GO:0016922	nuclear receptor binding	"Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974]	OMA
NV2t003195001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003196001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t003196001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t003196001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t003196001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t003196001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t003196001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t003196001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t003198001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t003199001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t003199001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003199001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003200001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003200002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003202001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003203001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003203001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t003203001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t003203001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t003203001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t003203001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t003203001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003203001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003206001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t003206001.1	biological_process	GO:0007221	positive regulation of transcription of Notch receptor target	"The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094]	InterPro
NV2t003206001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003206001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003206001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t003206001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t003208001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	PANTHER
NV2t003208001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t003208001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t003209001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t003209001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t003211001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003211001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003211001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t003211001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003211001.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t003211001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t003211001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003211001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t003211002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003211002.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t003211002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003212001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t003213001.1	biological_process	GO:0031062	obsolete positive regulation of histone methylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]	OMA
NV2t003213001.1	biological_process	GO:0045815	transcription initiation-coupled chromatin remodeling	"An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA." [PMID:34414474]	OMA
NV2t003213001.1	biological_process	GO:0071168	protein localization to chromatin	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]	OMA
NV2t003213001.1	biological_process	GO:0071168	protein localization to chromatin	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]	PANTHER
NV2t003213001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t003213002.1	biological_process	GO:0071168	protein localization to chromatin	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]	PANTHER
NV2t003214001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003214001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t003214001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003214001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003214001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003215001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t003215001.1	biological_process	GO:0048738	cardiac muscle tissue development	"The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]	OMA
NV2t003215001.1	biological_process	GO:0060047	heart contraction	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]	OMA
NV2t003215001.1	cellular_component	GO:0016011	dystroglycan complex	"A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609]	OMA
NV2t003215001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003215001.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t003215002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003216001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216001.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003216002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216002.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003216003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216003.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003216003.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	OMA
NV2t003216003.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t003216003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003216003.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t003216003.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t003216004.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216004.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003216005.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216005.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003216006.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216006.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003216007.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216007.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003216008.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216008.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003216009.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003216009.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t003217001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t003220001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003220001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003220001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t003220001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003220001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003221001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003221001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	PANTHER
NV2t003222001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003223001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003224001.1	biological_process	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	"Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle]	InterPro
NV2t003224001.1	biological_process	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	"Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle]	OMA
NV2t003224001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t003226001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t003226001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t003226001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t003226001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003226001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003226001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003227001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t003227001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003227001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003228001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t003228001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t003228001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t003228001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t003229001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t003229001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	InterPro
NV2t003229001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t003229001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t003229001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t003229001.1	cellular_component	GO:0000347	THO complex	"The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]	OMA
NV2t003229001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t003230001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	PANTHER
NV2t003230001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t003232001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t003232001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t003232001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t003232001.1	molecular_function	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]	OMA
NV2t003232001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t003233001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t003233001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t003233001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t003233001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t003233001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t003233001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003238001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003238001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t003238001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003240001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t003240001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t003242001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t003243001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t003243001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t003244001.1	cellular_component	GO:0042719	mitochondrial intermembrane space protein transporter complex	"Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]	PANTHER
NV2t003245001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t003245001.1	biological_process	GO:0007064	mitotic sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]	OMA
NV2t003245001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t003245001.1	biological_process	GO:0009314	response to radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]	OMA
NV2t003245001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t003245001.1	cellular_component	GO:0000779	condensed chromosome, centromeric region	"The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]	OMA
NV2t003245001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003245001.1	cellular_component	GO:0008278	cohesin complex	"A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]	OMA
NV2t003245001.1	cellular_component	GO:0008278	cohesin complex	"A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]	PANTHER
NV2t003245001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003245001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t003245001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003245001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003245001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t003245001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t003246001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t003246001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003246002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t003246002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003246003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t003246003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003247001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	InterPro
NV2t003247001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	OMA
NV2t003247001.1	molecular_function	GO:0004642	phosphoribosylformylglycinamidine synthase activity	"Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate." [EC:6.3.5.3, RHEA:17129]	OMA
NV2t003249001.1	molecular_function	GO:0017110	nucleoside diphosphate phosphatase activity	"Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate." [EC:3.6.1.6]	OMA
NV2t003249001.1	molecular_function	GO:0044715	8-oxo-dGDP phosphatase activity	"Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate." [GOC:pde, PMID:22556419, RHEA:32063]	PANTHER
NV2t003250002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t003251001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003251001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t003251002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003252001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	OMA
NV2t003252001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t003252001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003252001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t003252002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003252003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003252004.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	InterPro
NV2t003252005.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	InterPro
NV2t003253001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t003253001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t003253002.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t003254001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t003254001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003254002.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t003254002.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t003254002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003254002.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t003255001.1	biological_process	GO:0015813	L-glutamate transmembrane transport	"The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	OMA
NV2t003255001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003255001.1	molecular_function	GO:0015501	glutamate:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1]	OMA
NV2t003256001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003256002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003257001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t003257001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t003257001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t003257001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t003257001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t003257001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t003257001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t003257001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003257001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003257001.1	molecular_function	GO:0005104	fibroblast growth factor receptor binding	"Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb]	OMA
NV2t003257001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t003257001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t003258001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003258001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t003262001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003262002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003262003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003262003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003263001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	PANTHER
NV2t003265001.1	biological_process	GO:0006353	DNA-templated transcription termination	"The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template." [GOC:txnOH, PMID:15020047, PMID:18280161, PMID:30978344]	OMA
NV2t003265001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t003265001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	OMA
NV2t003265001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t003265001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t003265001.1	molecular_function	GO:0000993	RNA polymerase II complex binding	"Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH]	OMA
NV2t003265001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t003265001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t003266001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t003266001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003272001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003273001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003274001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003276001.1	biological_process	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t003276001.1	biological_process	GO:0001919	regulation of receptor recycling	"Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]	OMA
NV2t003276001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t003276001.1	biological_process	GO:0007040	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	OMA
NV2t003276001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t003276001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t003276001.1	biological_process	GO:0032008	positive regulation of TOR signaling	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t003276001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t003276001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	OMA
NV2t003276001.1	biological_process	GO:0042632	cholesterol homeostasis	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]	OMA
NV2t003276001.1	biological_process	GO:0043410	positive regulation of MAPK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]	OMA
NV2t003276001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t003276001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t003276001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t003276001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t003276001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	InterPro
NV2t003276001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	OMA
NV2t003276001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	PANTHER
NV2t003276001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t003276001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t003277001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t003279001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003279001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t003279001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003279001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003279002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t003279003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t003280001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003280002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003283001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t003283001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t003283001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003283001.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t003283001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t003283001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003284001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t003284001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t003284001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003284001.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t003284001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t003284001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003285001.1	biological_process	GO:0016358	dendrite development	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]	OMA
NV2t003285001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003285001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t003285001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t003285001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003285002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003286001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003286001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003286001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t003286001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t003286001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t003288001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003288001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t003288001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t003288001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t003288001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003288001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003291001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t003291001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t003291001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	OMA
NV2t003291001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t003291001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t003291001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t003291001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t003291001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003291001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t003291001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003294001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003294001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003294001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003294002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003294002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003294002.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t003294002.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t003294002.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t003294002.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t003294002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003295001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003295001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003295001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003295002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003295002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003295002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003295002.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t003295002.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t003295002.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t003295002.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t003295002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t003295002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003296001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003296001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003296001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003296002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003296002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003296002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003296003.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003296003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003296003.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003296004.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003296004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003296004.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003296005.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003296005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003296005.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003298001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t003298001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t003299001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003299002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003300001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003300001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003302001.1	biological_process	GO:0000086	G2/M transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]	OMA
NV2t003302001.1	biological_process	GO:0003013	circulatory system process	"A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]	OMA
NV2t003302001.1	biological_process	GO:0032414	positive regulation of ion transmembrane transporter activity	"Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb]	OMA
NV2t003302001.1	biological_process	GO:0035627	ceramide transport	"The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart]	OMA
NV2t003302001.1	biological_process	GO:0045332	phospholipid translocation	"The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]	OMA
NV2t003302001.1	biological_process	GO:0046865	terpenoid transport	"The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai]	OMA
NV2t003302001.1	biological_process	GO:0047484	regulation of response to osmotic stress	"Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai]	OMA
NV2t003302001.1	biological_process	GO:0070633	transepithelial transport	"The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363]	OMA
NV2t003302001.1	biological_process	GO:0072089	stem cell proliferation	"The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]	OMA
NV2t003302001.1	biological_process	GO:0098754	detoxification	"Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos]	OMA
NV2t003302001.1	biological_process	GO:0140115	export across plasma membrane	"The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg]	OMA
NV2t003302001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t003302001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t003302001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003302001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t003302001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003302001.1	molecular_function	GO:0008525	phosphatidylcholine transporter activity	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]	OMA
NV2t003302001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t003302001.1	molecular_function	GO:0015562	efflux transmembrane transporter activity	"Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003302001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003302001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t003302001.1	molecular_function	GO:0042626	ATPase-coupled transmembrane transporter activity	"Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003302001.1	molecular_function	GO:0046624	sphingolipid transporter activity	"Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732]	OMA
NV2t003302001.1	molecular_function	GO:0046943	carboxylic acid transmembrane transporter activity	"Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]	OMA
NV2t003302001.1	molecular_function	GO:0140303	intramembrane lipid transporter activity	"Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084]	OMA
NV2t003302001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t003304001.1	molecular_function	GO:0017110	nucleoside diphosphate phosphatase activity	"Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate." [EC:3.6.1.6]	OMA
NV2t003304001.1	molecular_function	GO:0044715	8-oxo-dGDP phosphatase activity	"Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate." [GOC:pde, PMID:22556419, RHEA:32063]	PANTHER
NV2t003305001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003305001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003307001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003309001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003309001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003309001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003311001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003311001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003314001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003314001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003314001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003314001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003314002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003314002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003314003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003314003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003314004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003314004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003321001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003322001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t003322001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t003322001.1	cellular_component	GO:0001669	acrosomal vesicle	"A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]	OMA
NV2t003322001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t003322001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003323001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003323001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t003323001.1	biological_process	GO:0006032	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t003323001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t003323001.1	molecular_function	GO:0004568	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	OMA
NV2t003323001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003323001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t003323001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t003324001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003324002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003324003.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003324004.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003324004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003324005.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t003324005.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003324005.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003324005.1	molecular_function	GO:0016229	steroid dehydrogenase activity	"Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]	OMA
NV2t003324005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003324006.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003324006.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003327001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003327001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t003327001.1	biological_process	GO:0006032	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t003327001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t003327001.1	molecular_function	GO:0004568	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	OMA
NV2t003327001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003327001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t003327001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t003328001.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003328002.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003328003.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003328004.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t003328004.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003328005.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003328006.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t003328006.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003328007.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t003328007.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003328008.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t003328008.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003329001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003332001.1	biological_process	GO:0051085	chaperone cofactor-dependent protein refolding	"The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]	PANTHER
NV2t003332001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003332001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003332001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t003333001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003334001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t003334001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t003334001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t003334001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t003334001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003334001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t003334001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t003336001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t003337001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003337001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003337001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t003337001.1	molecular_function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	OMA
NV2t003338001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003338001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003338002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003338002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003340001.1	biological_process	GO:0007064	mitotic sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]	InterPro
NV2t003341001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	PANTHER
NV2t003341001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003343001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003343001.1	molecular_function	GO:0004500	dopamine beta-monooxygenase activity	"Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]	InterPro
NV2t003343001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t003343001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t003343001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t003344001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003344002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003345001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t003345001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t003345001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003347001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003347001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003349001.1	biological_process	GO:0006892	post-Golgi vesicle-mediated transport	"The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]	OMA
NV2t003349001.1	biological_process	GO:0016482	cytosolic transport	"The directed movement of substances or organelles within the cytosol." [GOC:ai]	OMA
NV2t003349001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t003349001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t003349001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003349001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003349001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t003349001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t003350002.1	cellular_component	GO:0017053	transcription repressor complex	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]	InterPro
NV2t003350002.1	cellular_component	GO:0017053	transcription repressor complex	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]	OMA
NV2t003350002.1	cellular_component	GO:0031523	Myb complex	"A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]	PANTHER
NV2t003351001.1	biological_process	GO:0045002	double-strand break repair via single-strand annealing	"Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529]	InterPro
NV2t003351001.1	biological_process	GO:0045002	double-strand break repair via single-strand annealing	"Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529]	PANTHER
NV2t003352001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003352001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003352001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t003352001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003353001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t003353001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003353002.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t003353002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003357001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t003357001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t003357001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003357001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t003357001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003357001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t003357001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t003357001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t003357001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t003359001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t003360001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003360002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003360003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003361001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003361001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003361001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t003361001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003364001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003364001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003368001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	OMA
NV2t003368001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003368001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t003368001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t003368001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003368001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t003368001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t003369001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t003369001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003369001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003369001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t003369001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t003369001.1	biological_process	GO:0043968	obsolete histone H2A acetylation	"OBSOLETE. The modification of histone H2A by the addition of an acetyl group." [GOC:jl]	PANTHER
NV2t003369001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t003369001.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	OMA
NV2t003370001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t003370001.1	biological_process	GO:0036065	fucosylation	"The covalent attachment of a fucosyl group to an acceptor molecule." [GOC:sart, PMID:19948734]	OMA
NV2t003370001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t003370001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003370001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	OMA
NV2t003370001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t003372001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003372001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t003372002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003372002.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t003372003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003372003.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t003373001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003373001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003373002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003373002.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t003373003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003373003.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t003375001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t003375002.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t003377001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t003377001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003377001.1	molecular_function	GO:0043531	ADP binding	"Binding to ADP, adenosine 5'-diphosphate." [GOC:jl]	InterPro
NV2t003378001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003378001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	PANTHER
NV2t003378001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t003378001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t003378001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003379001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003379001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003379001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t003381001.1	biological_process	GO:0006835	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t003381001.1	biological_process	GO:0031670	cellular response to nutrient	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah]	OMA
NV2t003381001.1	biological_process	GO:0035461	vitamin transmembrane transport	"The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:bf]	OMA
NV2t003381001.1	biological_process	GO:0042886	amide transport	"The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]	OMA
NV2t003381001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t003381001.1	biological_process	GO:0071417	cellular response to organonitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah]	OMA
NV2t003381001.1	biological_process	GO:0072337	modified amino acid transport	"The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t003381001.1	biological_process	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	OMA
NV2t003381001.1	biological_process	GO:0098739	import across plasma membrane	"The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t003381001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t003381001.1	biological_process	GO:1905039	carboxylic acid transmembrane transport	"The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]	OMA
NV2t003381001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t003381001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t003381001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t003381001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t003381001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t003381001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t003381001.1	molecular_function	GO:0038024	cargo receptor activity	"Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles." [PMID:15239958, PMID:27903609]	OMA
NV2t003381001.1	molecular_function	GO:0072341	modified amino acid binding	"Binding to a modified amino acid." [GOC:mah]	OMA
NV2t003381001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t003381001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t003384001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003384001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003384001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t003384001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t003385001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t003385001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t003385001.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	OMA
NV2t003385001.1	biological_process	GO:0035695	mitophagy by internal vacuole formation	"The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes." [GOC:autophagy, GOC:bf, GOC:sp, PMID:21264228]	PANTHER
NV2t003385001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t003385002.1	biological_process	GO:0035695	mitophagy by internal vacuole formation	"The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes." [GOC:autophagy, GOC:bf, GOC:sp, PMID:21264228]	PANTHER
NV2t003387001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	PANTHER
NV2t003387001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t003387002.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	PANTHER
NV2t003387002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t003389001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003389001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003389001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t003390001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003390001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003390001.1	biological_process	GO:0006393	termination of mitochondrial transcription	"A transcription termination process that completes the production of a primary mitochondrial transcript." [PMID:29945721]	PANTHER
NV2t003390001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t003391001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003391001.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	PANTHER
NV2t003393001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t003393001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t003393001.1	biological_process	GO:0016525	negative regulation of angiogenesis	"Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]	InterPro
NV2t003393001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003394001.1	biological_process	GO:0097370	protein O-GlcNAcylation via threonine	"The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438]	OMA
NV2t003394001.1	biological_process	GO:0097370	protein O-GlcNAcylation via threonine	"The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438]	PANTHER
NV2t003394001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t003394001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t003394001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003394001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t003394002.1	biological_process	GO:0097370	protein O-GlcNAcylation via threonine	"The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438]	PANTHER
NV2t003394002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003394003.1	biological_process	GO:0097370	protein O-GlcNAcylation via threonine	"The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438]	PANTHER
NV2t003394003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003394004.1	biological_process	GO:0097370	protein O-GlcNAcylation via threonine	"The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438]	PANTHER
NV2t003394004.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003395001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003396001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003396001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003396002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003396003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003397001.1	biological_process	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	OMA
NV2t003397001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003397001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t003397001.1	biological_process	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t003397001.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t003397001.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	OMA
NV2t003397002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003397002.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t003397004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003397004.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t003397005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003397005.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t003397006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003397006.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t003397007.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003397007.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t003398001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003398001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003399001.1	cellular_component	GO:0035097	histone methyltransferase complex	"A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]	PANTHER
NV2t003399001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003400001.1	cellular_component	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	OMA
NV2t003400001.1	cellular_component	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	PANTHER
NV2t003401001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t003401001.1	biological_process	GO:0006544	glycine metabolic process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]	OMA
NV2t003401001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t003401001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t003401001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t003401001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t003401001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t003401001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t003401001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t003401001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t003401001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t003401001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003401001.1	molecular_function	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t003401001.1	molecular_function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t003401001.1	molecular_function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t003401001.1	molecular_function	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t003401001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t003401001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t003401001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t003401002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003401002.1	molecular_function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t003401002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t003401002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t003403001.1	biological_process	GO:0090646	mitochondrial tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw]	OMA
NV2t003403001.1	biological_process	GO:0097745	mitochondrial tRNA 5'-end processing	"The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:pf, PMID:21307182, PMID:26143376, PMID:27484477]	PANTHER
NV2t003403001.1	cellular_component	GO:0030678	mitochondrial ribonuclease P complex	"A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans." [GOC:mah, PMID:12045094, PMID:27187488]	OMA
NV2t003403001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003403001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t003403001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t003404001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003404002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003404003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003404003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t003405001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003405001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t003405001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003405002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003405002.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t003405002.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003405003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003405003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t003405003.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t003405003.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003405003.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t003405004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003405004.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t003405004.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003405005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003405005.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t003405005.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003405006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003405006.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t003405006.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003405007.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003405007.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t003405007.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003405008.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003405008.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t003405008.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003407001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003410001.1	biological_process	GO:0008643	carbohydrate transport	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]	OMA
NV2t003410001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003410001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003410001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t003410002.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003410003.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003410004.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003410005.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003410006.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003413001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003413001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003413002.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003415001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003415002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003417001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003417001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003418001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003419001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t003419001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t003419001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t003419001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003419001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003419001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003419001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t003419001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t003420001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003420001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t003420001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	InterPro
NV2t003420001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	OMA
NV2t003421001.1	cellular_component	GO:0110078	TTT Hsp90 cochaperone complex	"A Hsp90 cochaperone complex acting as an adapter between Hps90 and its substrates, members of the PIKK kinase family." [PMID:20810650, PMID:22505622, PMID:28827813, PMID:34233195]	InterPro
NV2t003424001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003424002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003430001.1	biological_process	GO:0000002	mitochondrial genome maintenance	"The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]	OMA
NV2t003430001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t003430001.1	biological_process	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	OMA
NV2t003430001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003430001.1	biological_process	GO:0072531	pyrimidine-containing compound transmembrane transport	"The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t003430001.1	biological_process	GO:1990519	pyrimidine nucleotide import into mitochondrion	"The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix." [PMID:16194150]	PANTHER
NV2t003430001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t003430001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t003430001.1	molecular_function	GO:0015215	nucleotide transmembrane transporter activity	"Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t003432001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t003432001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t003433001.1	biological_process	GO:1902004	positive regulation of amyloid-beta formation	"Any process that activates or increases the frequency, rate or extent of amyloid-beta formation." [GOC:dph, GOC:TermGenie, PMID:17098871]	PANTHER
NV2t003435001.1	biological_process	GO:0034250	positive regulation of amide metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]	OMA
NV2t003435001.1	biological_process	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t003435001.1	biological_process	GO:1902004	positive regulation of amyloid-beta formation	"Any process that activates or increases the frequency, rate or extent of amyloid-beta formation." [GOC:dph, GOC:TermGenie, PMID:17098871]	PANTHER
NV2t003435001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t003436001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003436001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003437001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t003437001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t003437001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003437001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t003437001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	OMA
NV2t003437001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t003438001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t003439001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t003439001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t003440001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003440001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t003440001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t003444001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003444001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003447001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t003447001.1	biological_process	GO:0006264	mitochondrial DNA replication	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]	OMA
NV2t003447001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t003447001.1	biological_process	GO:0009185	ribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003447001.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t003447001.1	biological_process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]	OMA
NV2t003447001.1	biological_process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]	OMA
NV2t003447001.1	biological_process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t003447001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003447001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t003447001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003447001.1	molecular_function	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	"Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t003447001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t003451001.1	biological_process	GO:0007528	neuromuscular junction development	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]	OMA
NV2t003451001.1	biological_process	GO:0061098	positive regulation of protein tyrosine kinase activity	"Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]	InterPro
NV2t003451001.1	biological_process	GO:0061098	positive regulation of protein tyrosine kinase activity	"Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]	OMA
NV2t003451001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t003454001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t003454001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t003454001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t003454001.1	biological_process	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	OMA
NV2t003454001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t003454001.1	biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t003454001.1	biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t003454001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t003454001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t003454001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t003454001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t003454001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t003454001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t003454001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t003454001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t003454001.1	molecular_function	GO:0032357	oxidized purine DNA binding	"Binding to a DNA region containing an oxidized purine residue." [GOC:vk]	OMA
NV2t003454001.1	molecular_function	GO:0051018	protein kinase A binding	"Binding to a protein kinase A." [GOC:ai]	OMA
NV2t003454001.1	molecular_function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate." [PMID:1698278, RHEA:66592]	OMA
NV2t003457001.1	biological_process	GO:0006537	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t003457001.1	biological_process	GO:0006537	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	PANTHER
NV2t003457001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003457001.1	molecular_function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3]	OMA
NV2t003457001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003457001.1	molecular_function	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	InterPro
NV2t003459001.1	biological_process	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	PANTHER
NV2t003459001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003459001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003459001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003459001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003459001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t003460001.1	biological_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	"The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]	InterPro
NV2t003460001.1	biological_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	"The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]	OMA
NV2t003462001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t003462001.1	molecular_function	GO:0015645	fatty acid ligase activity	"Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [GOC:cjk, GOC:mah]	OMA
NV2t003462001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t003462001.1	molecular_function	GO:0031956	medium-chain fatty acid-CoA ligase activity	"Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:48340]	PANTHER
NV2t003463001.1	cellular_component	GO:0030017	sarcomere	"The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]	OMA
NV2t003463001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003463001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003465001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003465002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003465003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003465004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003465005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003465006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003465007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003469001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	OMA
NV2t003469001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003469001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003469001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003475001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003475001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t003475001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003475001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t003480001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t003480001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003480001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003481001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003481001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t003481001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	PANTHER
NV2t003481002.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	PANTHER
NV2t003482001.1	biological_process	GO:0032237	activation of store-operated calcium channel activity	"A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah]	PANTHER
NV2t003482001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003482002.1	biological_process	GO:0032237	activation of store-operated calcium channel activity	"A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah]	PANTHER
NV2t003483001.1	biological_process	GO:0002757	immune response-activating signaling pathway	"The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add]	OMA
NV2t003483001.1	biological_process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]	OMA
NV2t003483001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003483001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t003483001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003483001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t003483001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t003483001.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t003483001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003483001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003483001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003483002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003484001.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t003484001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t003484002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t003484002.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t003484002.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t003484002.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	OMA
NV2t003484002.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t003484002.1	cellular_component	GO:0032588	trans-Golgi network membrane	"The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]	OMA
NV2t003484002.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t003484002.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t003484002.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	OMA
NV2t003484003.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t003484003.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t003485001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003485001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003485001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t003485001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t003485001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003486001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t003486001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t003486001.1	biological_process	GO:0006497	protein lipidation	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]	OMA
NV2t003486001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t003486001.1	biological_process	GO:0009791	post-embryonic development	"The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]	OMA
NV2t003486001.1	biological_process	GO:0010508	positive regulation of autophagy	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t003486001.1	biological_process	GO:0018410	C-terminal protein amino acid modification	"The alteration of the C-terminal amino acid residue in a protein." [GOC:mah]	OMA
NV2t003486001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	OMA
NV2t003486001.1	biological_process	GO:0042752	regulation of circadian rhythm	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]	OMA
NV2t003486001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t003486001.1	biological_process	GO:0044805	obsolete late nucleophagy	"OBSOLETE. A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM." [GOC:dgf, GOC:jl, PMID:22768199]	PANTHER
NV2t003486001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t003486001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t003486001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t003486001.1	molecular_function	GO:0019779	Atg8 activating enzyme activity	"Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]	OMA
NV2t003488001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003488001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003488001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003488002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003488002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003489001.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	OMA
NV2t003489001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003489001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t003489001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003489001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003489001.1	molecular_function	GO:0018024	obsolete histone lysine N-methyltransferase activity	"OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [RHEA:10024]	OMA
NV2t003489001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t003489002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003490001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003490001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003493001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t003493001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	InterPro
NV2t003493001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t003493001.1	molecular_function	GO:0005539	glycosaminoglycan binding	"Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t003493001.1	molecular_function	GO:0008449	N-acetylglucosamine-6-sulfatase activity	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]	OMA
NV2t003493001.1	molecular_function	GO:0008449	N-acetylglucosamine-6-sulfatase activity	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]	PANTHER
NV2t003494001.1	biological_process	GO:0042632	cholesterol homeostasis	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]	OMA
NV2t003494001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	OMA
NV2t003494001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t003494001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t003494001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t003494001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003494001.1	molecular_function	GO:0004301	epoxide hydrolase activity	"Catalysis of the reaction: an epoxide + H2O = an ethanediol." [EC:3.3.2.10]	OMA
NV2t003494001.1	molecular_function	GO:0042577	lipid phosphatase activity	"Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]	OMA
NV2t003494002.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t003494002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003495001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t003495001.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	InterPro
NV2t003495001.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t003495002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t003495002.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	InterPro
NV2t003495002.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t003495003.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t003495003.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	InterPro
NV2t003495003.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t003495004.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t003495004.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t003495005.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t003495005.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t003495005.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t003495005.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t003495005.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	OMA
NV2t003495005.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003495005.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003495005.1	cellular_component	GO:0005968	Rab-protein geranylgeranyltransferase complex	"An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein)." [GOC:jl, PMID:11886217]	OMA
NV2t003495005.1	molecular_function	GO:0005092	GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]	OMA
NV2t003496001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t003496001.1	biological_process	GO:1990519	pyrimidine nucleotide import into mitochondrion	"The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix." [PMID:16194150]	PANTHER
NV2t003502001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003502001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t003502001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003504001.1	biological_process	GO:0007605	sensory perception of sound	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]	OMA
NV2t003504001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003504001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003504001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003504001.1	molecular_function	GO:0015106	bicarbonate transmembrane transporter activity	"Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]	OMA
NV2t003504001.1	molecular_function	GO:0015108	chloride transmembrane transporter activity	"Enables the transfer of chloride ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t003504001.1	molecular_function	GO:0015116	sulfate transmembrane transporter activity	"Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]	OMA
NV2t003504001.1	molecular_function	GO:0015291	secondary active transmembrane transporter activity	"Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]	OMA
NV2t003504001.1	molecular_function	GO:0019531	oxalate transmembrane transporter activity	"Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]	OMA
NV2t003505001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003505001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t003505001.1	biological_process	GO:0006516	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003505001.1	biological_process	GO:0006516	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t003505001.1	molecular_function	GO:0015923	mannosidase activity	"Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai]	OMA
NV2t003506001.1	molecular_function	GO:0003721	telomerase RNA reverse transcriptase activity	"Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242]	InterPro
NV2t003506001.1	molecular_function	GO:0003964	RNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]	InterPro
NV2t003506001.1	molecular_function	GO:0070034	telomerase RNA binding	"Binding to the telomerase RNA template." [GOC:krc, PMID:16884717]	PANTHER
NV2t003506002.1	molecular_function	GO:0070034	telomerase RNA binding	"Binding to the telomerase RNA template." [GOC:krc, PMID:16884717]	PANTHER
NV2t003507001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003507001.1	biological_process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]	OMA
NV2t003507001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t003507001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	OMA
NV2t003507001.1	cellular_component	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	OMA
NV2t003507001.1	cellular_component	GO:0099738	cell cortex region	"The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos]	OMA
NV2t003507001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t003507001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t003507001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t003507001.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t003507001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t003510001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t003510001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003510001.1	biological_process	GO:0006183	GTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]	PANTHER
NV2t003510001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003510001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003510001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t003510002.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t003510002.1	biological_process	GO:0006183	GTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]	PANTHER
NV2t003510002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003510002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003512001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	PANTHER
NV2t003512001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003512001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t003512001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t003512002.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	PANTHER
NV2t003512002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003512002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t003512003.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	PANTHER
NV2t003512003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003512003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t003512004.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	PANTHER
NV2t003512004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003512004.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t003514001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003514001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003514001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t003514001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t003517001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t003517001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t003517001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t003517001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003517001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003517001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t003517001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003517001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t003517002.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003517003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003517003.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003517004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003517004.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003518001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003518001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003518001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003519001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t003519001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t003519001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t003519001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003519001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003519001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t003519001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003519001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t003520001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003521001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003521001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t003521001.1	biological_process	GO:0044344	cellular response to fibroblast growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf]	OMA
NV2t003521001.1	biological_process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t003521001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	OMA
NV2t003521001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t003521001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003523001.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t003523001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003524001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003524001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t003524001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003524002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003524002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t003524002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003527001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t003527001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003527002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t003527002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003529001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003529001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t003529001.1	molecular_function	GO:0047631	ADP-ribose diphosphatase activity	"Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]	OMA
NV2t003529001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	PANTHER
NV2t003529002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003529002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	PANTHER
NV2t003529003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003529003.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	PANTHER
NV2t003532001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t003533001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003533001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003533001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003540001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t003540001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003540001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t003540001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t003542001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003542001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003542001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t003542001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003542002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003542002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003542003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003542003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003542003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t003542003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003542004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003542004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003542004.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t003542004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003542005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003542005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003542005.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t003542005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003542006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003542006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003542006.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t003542006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003544001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003544002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003545001.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	OMA
NV2t003545001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t003545001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t003545001.1	biological_process	GO:0045921	positive regulation of exocytosis	"Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t003545001.1	biological_process	GO:0051851	modulation by host of symbiont process	"The process in which an host alters or subverts a process in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]	OMA
NV2t003545001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t003545001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t003545001.1	cellular_component	GO:0045335	phagocytic vesicle	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003545001.1	cellular_component	GO:0045335	phagocytic vesicle	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t003545001.1	cellular_component	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	OMA
NV2t003545001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t003545001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003545001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t003545001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t003547001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t003547001.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	PANTHER
NV2t003547001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t003547001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	InterPro
NV2t003547001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t003547001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	OMA
NV2t003548001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t003548001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003548001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t003548001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003548001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	InterPro
NV2t003548001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	OMA
NV2t003549001.1	molecular_function	GO:0042392	sphingosine-1-phosphate phosphatase activity	"Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:8663293]	PANTHER
NV2t003550001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	OMA
NV2t003550001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t003550001.1	cellular_component	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	"A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]	OMA
NV2t003550001.1	cellular_component	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	"A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]	PANTHER
NV2t003550001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t003551001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003551001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003551002.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003551002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003551003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003551003.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003551003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003551003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003551003.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t003551004.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003551004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003551005.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003551005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003551006.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003551006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003551007.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003551007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003552001.1	biological_process	GO:0032922	circadian regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]	OMA
NV2t003552001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t003552001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003552001.1	molecular_function	GO:0004535	poly(A)-specific ribonuclease activity	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]	OMA
NV2t003553001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t003553001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t003553001.1	cellular_component	GO:0042734	presynaptic membrane	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]	OMA
NV2t003553001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t003553001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t003553001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003555001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003560001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003560001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003561001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003561001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003562001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003562001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003562001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t003562001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003564001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003564001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003564001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003564001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003565001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t003566001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t003566001.1	biological_process	GO:0003006	developmental process involved in reproduction	"A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]	OMA
NV2t003566001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003566001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t003566001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	PANTHER
NV2t003566001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	OMA
NV2t003566001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t003566001.1	biological_process	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	OMA
NV2t003566001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t003566001.1	biological_process	GO:0046601	positive regulation of centriole replication	"Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai]	OMA
NV2t003566001.1	biological_process	GO:0048568	embryonic organ development	"Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t003566001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t003566001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t003566001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003566001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003566001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t003566001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t003566001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t003566001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t003566001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003566001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003566001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t003567001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003568001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	InterPro
NV2t003568001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003569001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t003569001.1	biological_process	GO:0030834	regulation of actin filament depolymerization	"Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t003569001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003569001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003569001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003569001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003570001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t003570001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t003570001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t003570001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003570001.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	OMA
NV2t003570001.1	molecular_function	GO:0004377	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity	"Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage." [EC:2.4.1.131]	InterPro
NV2t003570001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003573001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t003574001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t003574001.1	biological_process	GO:0101030	tRNA-guanine transglycosylation	"The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine." [GOC:PomBase, GOC:vw, PMID:24911101]	PANTHER
NV2t003575001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t003575001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t003575001.1	molecular_function	GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd]	PANTHER
NV2t003575002.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t003575002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t003575002.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t003575002.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t003575002.1	molecular_function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]	OMA
NV2t003575002.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t003575002.1	molecular_function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]	OMA
NV2t003575002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t003575002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t003575002.1	molecular_function	GO:0106018	phosphatidylinositol-3,5-bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd]	PANTHER
NV2t003576001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t003576001.1	molecular_function	GO:0008139	nuclear localization sequence binding	"Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai]	OMA
NV2t003576001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t003576001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t003577001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003578001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t003578001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t003578001.1	biological_process	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	OMA
NV2t003578001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t003578001.1	biological_process	GO:1901564	organonitrogen compound metabolic process	"The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t003578001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t003578001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003578001.1	molecular_function	GO:0017040	N-acylsphingosine amidohydrolase activity	"Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]	OMA
NV2t003578001.1	molecular_function	GO:0017040	N-acylsphingosine amidohydrolase activity	"Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]	PANTHER
NV2t003578001.1	molecular_function	GO:0017064	fatty acid amide hydrolase activity	"Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid." [PMID:15952893]	InterPro
NV2t003579001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	OMA
NV2t003579001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003579001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	OMA
NV2t003579001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	PANTHER
NV2t003579001.1	molecular_function	GO:0032977	membrane insertase activity	"Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]	OMA
NV2t003580001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003580002.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003580003.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003580004.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t003581001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t003581001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t003582001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003582001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t003582001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t003582001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t003582001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t003582001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t003582001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t003582001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003582001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003582001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003585001.1	biological_process	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]	OMA
NV2t003585001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t003585001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003585001.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	InterPro
NV2t003585001.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	PANTHER
NV2t003585001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t003585001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t003585001.1	molecular_function	GO:0043167	ion binding	"Binding to an ion, a charged atoms or groups of atoms." [GOC:jl]	OMA
NV2t003585001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t003587001.1	cellular_component	GO:0072487	MSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]	PANTHER
NV2t003590001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t003590002.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t003590002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003590003.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t003590003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003590004.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t003590004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003590005.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t003590005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003590006.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	OMA
NV2t003590006.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t003590006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003590006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003591002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003591002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003591002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t003592001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003592001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003592001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t003592001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t003592001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003593001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003593001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003593001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t003594001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003594001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t003594001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t003594001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t003594001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003595001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t003595001.1	biological_process	GO:1901796	regulation of signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	OMA
NV2t003595001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003595001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003595001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003597001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t003597001.1	biological_process	GO:0045010	actin nucleation	"The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]	OMA
NV2t003597001.1	biological_process	GO:0051014	actin filament severing	"The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]	OMA
NV2t003597001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t003597001.1	biological_process	GO:0051693	actin filament capping	"The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	OMA
NV2t003597001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003597001.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t003597001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t003597001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t003602001.1	biological_process	GO:0035751	regulation of lysosomal lumen pH	"Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:rph]	OMA
NV2t003602001.1	biological_process	GO:0051454	intracellular pH elevation	"Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]	OMA
NV2t003602001.1	biological_process	GO:0070050	neuron cellular homeostasis	"The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]	OMA
NV2t003602001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	OMA
NV2t003602001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t003602001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t003602001.1	molecular_function	GO:0005504	fatty acid binding	"Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]	OMA
NV2t003602001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	InterPro
NV2t003602001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t003602001.1	molecular_function	GO:0022841	potassium ion leak channel activity	"Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003603001.1	biological_process	GO:0001731	formation of translation preinitiation complex	"The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]	PANTHER
NV2t003603001.1	biological_process	GO:0002183	cytoplasmic translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]	OMA
NV2t003603001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t003603001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003603001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t003603001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t003603001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t003609001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003609001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t003609001.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t003609001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t003609001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003609001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003609001.1	molecular_function	GO:0005109	frizzled binding	"Binding to a frizzled (fz) receptor." [GOC:ceb]	OMA
NV2t003609001.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t003609002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003609002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003611001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003611001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003611002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003611002.1	biological_process	GO:0016331	morphogenesis of embryonic epithelium	"The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]	OMA
NV2t003611002.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t003611002.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t003611002.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t003611002.1	biological_process	GO:0048562	embryonic organ morphogenesis	"Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t003611002.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t003611002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t003611002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003611002.1	biological_process	GO:0090596	sensory organ morphogenesis	"Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]	OMA
NV2t003611002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003611002.1	molecular_function	GO:0005109	frizzled binding	"Binding to a frizzled (fz) receptor." [GOC:ceb]	OMA
NV2t003611002.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t003611003.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003611003.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003611004.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003611004.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003611005.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003611005.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003611006.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003611006.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003613001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t003613001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t003613001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003613001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t003613001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t003613001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003615001.1	biological_process	GO:0007274	neuromuscular synaptic transmission	"The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]	OMA
NV2t003615001.1	biological_process	GO:0048167	regulation of synaptic plasticity	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]	OMA
NV2t003615001.1	biological_process	GO:0048790	maintenance of presynaptic active zone structure	"A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]	OMA
NV2t003615001.1	cellular_component	GO:0048788	cytoskeleton of presynaptic active zone	"The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438]	OMA
NV2t003615001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t003615001.1	molecular_function	GO:0098882	structural constituent of presynaptic active zone	"The action of a molecule that contributes to the structural integrity of a presynaptic active zone." [GOC:dos]	PANTHER
NV2t003615002.1	molecular_function	GO:0098882	structural constituent of presynaptic active zone	"The action of a molecule that contributes to the structural integrity of a presynaptic active zone." [GOC:dos]	PANTHER
NV2t003616001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t003616001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003616001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003616002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t003616002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003617001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003617001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003617001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003618001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003618001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003618001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003618001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003621001.1	biological_process	GO:0022904	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	InterPro
NV2t003621001.1	biological_process	GO:0022904	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	OMA
NV2t003621001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t003621001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t003622001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t003622001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t003622001.1	biological_process	GO:0006428	isoleucyl-tRNA aminoacylation	"The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t003622001.1	biological_process	GO:0006428	isoleucyl-tRNA aminoacylation	"The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t003622001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003622001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t003622001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	InterPro
NV2t003622001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t003622001.1	molecular_function	GO:0002161	aminoacyl-tRNA editing activity	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]	OMA
NV2t003622001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t003622001.1	molecular_function	GO:0004822	isoleucine-tRNA ligase activity	"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+." [EC:6.1.1.5, RHEA:11060]	InterPro
NV2t003622001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003624001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	PANTHER
NV2t003624001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003627001.1	biological_process	GO:0000255	allantoin metabolic process	"The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684]	InterPro
NV2t003627001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t003627001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t003627001.1	biological_process	GO:0072523	purine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t003627001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t003627001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t003627001.1	molecular_function	GO:0051997	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	"Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2." [MetaCyc:RXN-6201]	PANTHER
NV2t003628001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003628001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t003628002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003628002.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t003628003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003628003.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t003628004.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t003628004.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t003628004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003628004.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t003628004.1	biological_process	GO:1905039	carboxylic acid transmembrane transport	"The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]	OMA
NV2t003628004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003628004.1	molecular_function	GO:0005343	organic acid:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1]	OMA
NV2t003628004.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t003631001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003631001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003631001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003632001.1	biological_process	GO:0030513	positive regulation of BMP signaling pathway	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]	PANTHER
NV2t003632001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003635001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t003636001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t003636001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003636001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003636001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003636001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t003636001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003636001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t003637001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003637001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t003637001.1	cellular_component	GO:0097060	synaptic membrane	"A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]	PANTHER
NV2t003637001.1	molecular_function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate." [RHEA:14653]	OMA
NV2t003637001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003637001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t003637002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003637002.1	cellular_component	GO:0097060	synaptic membrane	"A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]	PANTHER
NV2t003637002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003637002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t003638001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003638002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003638002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003638003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003638004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003639001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t003639001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t003639001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t003639001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t003639002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t003639002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t003639002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t003639002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t003640001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t003640001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t003640001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t003640001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t003640001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t003640001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t003640001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t003640001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003640001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003640001.1	molecular_function	GO:0004839	ubiquitin activating enzyme activity	"Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme]	OMA
NV2t003640001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t003640002.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t003640002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t003640002.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t003640003.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t003640003.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t003642001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t003642001.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t003642001.1	biological_process	GO:0035751	regulation of lysosomal lumen pH	"Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:rph]	OMA
NV2t003642001.1	biological_process	GO:0071421	manganese ion transmembrane transport	"A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t003642001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t003642001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t003642001.1	cellular_component	GO:0032588	trans-Golgi network membrane	"The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]	OMA
NV2t003642001.1	molecular_function	GO:0005384	manganese ion transmembrane transporter activity	"Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t003642001.1	molecular_function	GO:0015085	calcium ion transmembrane transporter activity	"Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf, RHEA:29671]	OMA
NV2t003643001.1	biological_process	GO:0016050	vesicle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]	OMA
NV2t003643001.1	biological_process	GO:0030003	intracellular monoatomic cation homeostasis	"A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:mah]	OMA
NV2t003643001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003643001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t003643001.1	cellular_component	GO:0000323	lytic vacuole	"A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]	OMA
NV2t003643001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t003643001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t003643001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003643001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t003643001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t003643001.1	molecular_function	GO:0005247	voltage-gated chloride channel activity	"Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003643001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003643001.1	molecular_function	GO:0015299	obsolete solute:proton antiporter activity	"OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]	PANTHER
NV2t003643002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003643002.1	molecular_function	GO:0015299	obsolete solute:proton antiporter activity	"OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]	PANTHER
NV2t003644001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t003646001.1	biological_process	GO:0030155	regulation of cell adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]	InterPro
NV2t003646001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003649001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t003649001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003649001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003649001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t003649001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003649001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t003649001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t003649001.1	molecular_function	GO:0008175	tRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah]	OMA
NV2t003649001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003649001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t003649001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t003649001.1	molecular_function	GO:0106335	tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity	"Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208]	PANTHER
NV2t003650001.1	biological_process	GO:0006144	purine nucleobase metabolic process	"The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]	OMA
NV2t003650001.1	biological_process	GO:0006144	purine nucleobase metabolic process	"The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]	PANTHER
NV2t003650001.1	molecular_function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	OMA
NV2t003650001.1	molecular_function	GO:0033971	hydroxyisourate hydrolase activity	"Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+." [EC:3.5.2.17, RHEA:23736]	InterPro
NV2t003650003.1	molecular_function	GO:0033971	hydroxyisourate hydrolase activity	"Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+." [EC:3.5.2.17, RHEA:23736]	InterPro
NV2t003651001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t003651001.1	biological_process	GO:0070836	caveola assembly	"The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane." [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858]	InterPro
NV2t003651001.1	biological_process	GO:0071709	membrane assembly	"The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]	OMA
NV2t003651001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t003651001.1	cellular_component	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	OMA
NV2t003651001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t003652002.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	OMA
NV2t003652002.1	biological_process	GO:0010457	centriole-centriole cohesion	"The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]	OMA
NV2t003652002.1	biological_process	GO:0045724	positive regulation of cilium assembly	"Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]	OMA
NV2t003652002.1	biological_process	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t003652002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t003652002.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t003652002.1	molecular_function	GO:0008022	obsolete protein C-terminus binding	"OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t003653001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003653002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003654001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003655001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003655001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t003656001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t003657001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t003657001.1	cellular_component	GO:0000974	Prp19 complex	"A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]	OMA
NV2t003657001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t003657001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t003657001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t003657001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t003657001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003658001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t003658001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003658001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003659001.1	molecular_function	GO:0047429	nucleoside triphosphate diphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]	InterPro
NV2t003659001.1	molecular_function	GO:0047429	nucleoside triphosphate diphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]	OMA
NV2t003661001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t003662001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t003662001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003662001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t003662001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t003664001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003664001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t003664001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t003664001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t003664001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t003664001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t003664001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003664002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003664002.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t003664002.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003666001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t003666001.1	biological_process	GO:0006354	DNA-templated transcription elongation	"The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]	OMA
NV2t003666001.1	biological_process	GO:0006362	transcription elongation by RNA polymerase I	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah, GOC:txnOH]	PANTHER
NV2t003666001.1	biological_process	GO:0042790	nucleolar large rRNA transcription by RNA polymerase I	"The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t003666001.1	biological_process	GO:0070897	transcription preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]	OMA
NV2t003666001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003666001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t003666001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003668001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003668001.1	biological_process	GO:0006013	mannose metabolic process	"The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]	InterPro
NV2t003668001.1	biological_process	GO:0009313	oligosaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	PANTHER
NV2t003668001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t003669001.1	biological_process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	"Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai]	PANTHER
NV2t003669001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003669001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	InterPro
NV2t003669001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	OMA
NV2t003671001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t003671001.1	biological_process	GO:0010951	negative regulation of endopeptidase activity	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t003671001.1	biological_process	GO:0031330	negative regulation of cellular catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t003671001.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	OMA
NV2t003671001.1	biological_process	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	"Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai]	PANTHER
NV2t003671001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003671001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t003671001.1	molecular_function	GO:0002020	protease binding	"Binding to a protease or a peptidase." [GOC:hjd]	OMA
NV2t003671001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003671001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	InterPro
NV2t003671001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	OMA
NV2t003673001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t003673001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t003673001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t003674001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t003674001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t003674001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t003674001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t003674002.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t003676001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t003676001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t003676001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003676001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t003676001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t003676002.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t003683001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t003683001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t003683001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t003683001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t003683001.1	biological_process	GO:0032042	mitochondrial DNA metabolic process	"The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah]	OMA
NV2t003683001.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	InterPro
NV2t003683001.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	OMA
NV2t003683001.1	biological_process	GO:0097681	double-strand break repair via alternative nonhomologous end joining	"An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining]	OMA
NV2t003683001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003683001.1	cellular_component	GO:0070421	DNA ligase III-XRCC1 complex	"A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair." [PMID:15141024, PMID:7760816]	PANTHER
NV2t003683001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t003683001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t003683001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003683001.1	molecular_function	GO:0003909	DNA ligase activity	"Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094]	InterPro
NV2t003683001.1	molecular_function	GO:0003910	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	OMA
NV2t003683001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003683001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003687001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003687001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t003687001.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t003687001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t003687001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003687001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003687001.1	molecular_function	GO:0005109	frizzled binding	"Binding to a frizzled (fz) receptor." [GOC:ceb]	OMA
NV2t003687001.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t003687002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003687002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003689001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003689001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003689002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003689002.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t003689002.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t003689002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t003689002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003689002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003689002.1	molecular_function	GO:0005109	frizzled binding	"Binding to a frizzled (fz) receptor." [GOC:ceb]	OMA
NV2t003689002.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t003689003.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003689003.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003689004.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003689004.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003689005.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003689005.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003691001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t003691001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003692001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003692001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003693001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t003695001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003695001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t003696001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003696001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003696001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t003696001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003696001.1	molecular_function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	OMA
NV2t003696002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003696002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t003697002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003704001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t003704001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t003704001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t003704001.1	biological_process	GO:0048066	developmental pigmentation	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]	OMA
NV2t003704001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003704001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003704001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t003705001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003705001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003705002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003705003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003705004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003706001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003706001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003706002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003706003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003706004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003707001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t003707001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t003707001.1	biological_process	GO:0016075	rRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]	PANTHER
NV2t003707001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t003707001.1	biological_process	GO:0071027	nuclear RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]	OMA
NV2t003707001.1	cellular_component	GO:0000176	nuclear exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t003707001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t003707001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003707001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t003707001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t003707001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t003707001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t003707001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t003707001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003707002.1	biological_process	GO:0016075	rRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]	PANTHER
NV2t003707002.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t003709001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t003709001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t003709001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t003709001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t003709001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003709001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003710001.1	biological_process	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	OMA
NV2t003710001.1	biological_process	GO:0090287	regulation of cellular response to growth factor stimulus	"Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]	OMA
NV2t003710001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t003710001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003710001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t003710001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t003710002.1	biological_process	GO:0000350	generation of catalytic spliceosome for second transesterification step	"Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]	InterPro
NV2t003710002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t003711001.1	biological_process	GO:0006165	obsolete nucleoside diphosphate phosphorylation	"OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	OMA
NV2t003711001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t003711001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	OMA
NV2t003711001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003711001.1	biological_process	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003711001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t003711001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	PANTHER
NV2t003713001.1	biological_process	GO:0006165	obsolete nucleoside diphosphate phosphorylation	"OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	OMA
NV2t003713001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t003713001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	OMA
NV2t003713001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003713001.1	biological_process	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003713001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003713001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003713001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t003713001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	PANTHER
NV2t003718001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t003718001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003718001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t003719001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t003719001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t003719001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	OMA
NV2t003720001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003720001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t003720001.1	biological_process	GO:0032793	positive regulation of CREB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]	InterPro
NV2t003720001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t003720001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t003720001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t003720001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003720001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003722001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t003722001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t003722001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	OMA
NV2t003722001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t003722001.1	cellular_component	GO:0001725	stress fiber	"A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381]	OMA
NV2t003722001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t003722001.1	cellular_component	GO:0031105	septin complex	"A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632]	OMA
NV2t003722001.1	cellular_component	GO:0032153	cell division site	"The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]	OMA
NV2t003722001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t003722001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003722001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t003722001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t003722001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t003723001.1	biological_process	GO:0036444	calcium import into the mitochondrion	"A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix." [GOC:vw]	OMA
NV2t003723001.1	biological_process	GO:0051560	mitochondrial calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]	OMA
NV2t003723001.1	cellular_component	GO:0034704	calcium channel complex	"An ion channel complex through which calcium ions pass." [GOC:mah]	OMA
NV2t003723001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t003723001.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	PANTHER
NV2t003723001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003723001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003725001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003726001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t003726002.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t003727001.1	biological_process	GO:0006336	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	PANTHER
NV2t003729001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t003729001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t003729001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t003729001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t003729001.1	biological_process	GO:0035493	SNARE complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468]	OMA
NV2t003729001.1	biological_process	GO:0090161	Golgi ribbon formation	"The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t003729001.1	biological_process	GO:0098876	vesicle-mediated transport to the plasma membrane	"The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos]	OMA
NV2t003729001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t003729001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t003729001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t003729001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t003733001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t003733001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t003733001.1	biological_process	GO:0015918	sterol transport	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]	OMA
NV2t003733001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t003733001.1	biological_process	GO:0019218	regulation of steroid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]	OMA
NV2t003733001.1	biological_process	GO:0032366	intracellular sterol transport	"The directed movement of sterols within cells." [GOC:mah]	InterPro
NV2t003733001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t003733001.1	biological_process	GO:0032386	regulation of intracellular transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t003733001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t003733001.1	biological_process	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t003733001.1	biological_process	GO:0097035	regulation of membrane lipid distribution	"Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909]	OMA
NV2t003733001.1	biological_process	GO:0097036	regulation of plasma membrane sterol distribution	"Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [GOC:mah, PMID:18441123, PMID:20823909]	PANTHER
NV2t003733001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t003733001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t003733001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t003733001.1	cellular_component	GO:0071782	endoplasmic reticulum tubular network	"A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	OMA
NV2t003733002.1	biological_process	GO:0032366	intracellular sterol transport	"The directed movement of sterols within cells." [GOC:mah]	InterPro
NV2t003733002.1	biological_process	GO:0097036	regulation of plasma membrane sterol distribution	"Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [GOC:mah, PMID:18441123, PMID:20823909]	PANTHER
NV2t003733003.1	biological_process	GO:0032366	intracellular sterol transport	"The directed movement of sterols within cells." [GOC:mah]	InterPro
NV2t003733003.1	biological_process	GO:0097036	regulation of plasma membrane sterol distribution	"Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [GOC:mah, PMID:18441123, PMID:20823909]	PANTHER
NV2t003735001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003735001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003735001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t003735001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t003735001.1	molecular_function	GO:0005006	epidermal growth factor receptor activity	"Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf]	OMA
NV2t003735001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003735001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003735001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003736001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003736002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003736003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003736003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003737001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003739001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t003739001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t003739001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003739001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003739001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t003739001.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	OMA
NV2t003739001.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	PANTHER
NV2t003739001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003739002.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t003739002.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	PANTHER
NV2t003740001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t003740001.1	biological_process	GO:0034454	microtubule anchoring at centrosome	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]	OMA
NV2t003740001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t003740001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t003740001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	OMA
NV2t003740001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	PANTHER
NV2t003740001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003740001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t003740001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t003740001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t003740002.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	PANTHER
NV2t003743001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003743001.1	molecular_function	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t003745001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003745001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t003745001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t003748001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t003748001.1	biological_process	GO:0030150	protein import into mitochondrial matrix	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]	InterPro
NV2t003748001.1	biological_process	GO:0044743	protein transmembrane import into intracellular organelle	"The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]	OMA
NV2t003748001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t003748001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t003748001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t003749001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t003749001.1	biological_process	GO:0043041	amino acid activation for nonribosomal peptide biosynthetic process	"Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl]	OMA
NV2t003749001.1	biological_process	GO:0043041	amino acid activation for nonribosomal peptide biosynthetic process	"Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl]	PANTHER
NV2t003749001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003749001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t003750002.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t003750002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003751001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003752001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t003752001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t003752001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t003754001.1	biological_process	GO:0008210	estrogen metabolic process	"The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]	PANTHER
NV2t003754001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003754002.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t003754002.1	biological_process	GO:0008209	androgen metabolic process	"The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732]	OMA
NV2t003754002.1	biological_process	GO:0008210	estrogen metabolic process	"The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]	OMA
NV2t003754002.1	biological_process	GO:0008210	estrogen metabolic process	"The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]	PANTHER
NV2t003754002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t003754002.1	molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	"Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]	OMA
NV2t003754002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003754003.1	biological_process	GO:0008210	estrogen metabolic process	"The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]	PANTHER
NV2t003754003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003755002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003755002.1	biological_process	GO:0006959	humoral immune response	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]	OMA
NV2t003755002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003755002.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t003755002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003755002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t003755003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003755003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003758001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t003758001.1	biological_process	GO:0036158	outer dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t003758001.1	biological_process	GO:0036159	inner dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t003758001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t003758001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t003758001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t003758001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t003759001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t003760001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t003760001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t003760001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t003760001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t003760001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003760001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t003760001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t003762001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t003762001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t003762001.1	molecular_function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]	OMA
NV2t003762001.1	molecular_function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019]	PANTHER
NV2t003763001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003763001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003763001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003763001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003763001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003763001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003763001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003767001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003767001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t003767002.1	biological_process	GO:0006986	response to unfolded protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]	OMA
NV2t003767002.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t003767002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003767002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t003767002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t003768001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t003768001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003768002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003768002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003769001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	PANTHER
NV2t003770001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t003771001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t003771001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003773001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t003774001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t003774001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t003774001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t003775001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t003775001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003775001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t003775001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t003776001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003776002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003776003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003776004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003777001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t003777001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t003777001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t003777001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t003777001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003779001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003779001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003779001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t003781001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t003781001.1	molecular_function	GO:0008973	phosphopentomutase activity	"Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7]	PANTHER
NV2t003781001.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	InterPro
NV2t003781002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003781002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t003781002.1	biological_process	GO:0034654	nucleobase-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	OMA
NV2t003781002.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t003781002.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t003781002.1	biological_process	GO:0046128	purine ribonucleoside metabolic process	"The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]	OMA
NV2t003781002.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t003781002.1	biological_process	GO:0072522	purine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t003781002.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t003781002.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t003781002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003781002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	InterPro
NV2t003781002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t003781002.1	molecular_function	GO:0004614	phosphoglucomutase activity	"Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2]	OMA
NV2t003781002.1	molecular_function	GO:0008973	phosphopentomutase activity	"Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7]	PANTHER
NV2t003781002.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	InterPro
NV2t003781003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003781003.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t003781003.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	InterPro
NV2t003781003.1	molecular_function	GO:0008973	phosphopentomutase activity	"Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7]	PANTHER
NV2t003781003.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	InterPro
NV2t003782001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t003782002.1	biological_process	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	"The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020]	InterPro
NV2t003782002.1	biological_process	GO:0032787	monocarboxylic acid metabolic process	"The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]	OMA
NV2t003782002.1	biological_process	GO:0042182	ketone catabolic process	"The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]	OMA
NV2t003782002.1	biological_process	GO:0046185	aldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t003782002.1	biological_process	GO:0046929	negative regulation of neurotransmitter secretion	"Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai]	OMA
NV2t003782002.1	biological_process	GO:1901615	organic hydroxy compound metabolic process	"The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t003782002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t003782002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t003782002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003782002.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t003782003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t003783001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t003783001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003783001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t003783001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t003783001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t003783001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t003783001.1	biological_process	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	OMA
NV2t003783001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t003783001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003783001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003783001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t003783002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003783002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003783003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783003.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783004.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783005.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783006.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783006.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783007.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783007.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783008.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783008.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783009.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783009.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783010.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783010.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783011.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783011.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783012.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783012.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783013.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783013.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783014.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783014.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783015.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783015.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003783016.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t003783016.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t003784001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t003784001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t003784001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t003784001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t003784001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t003784001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003784001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t003784001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t003784001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t003784001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t003786001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t003787001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t003787001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t003787001.1	cellular_component	GO:0000138	Golgi trans cisterna	"The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]	OMA
NV2t003787001.1	cellular_component	GO:0005797	Golgi medial cisterna	"The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]	OMA
NV2t003787001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t003787001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003787001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003787001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003789001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t003789001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003790001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	InterPro
NV2t003790001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t003790001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	OMA
NV2t003790001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	PANTHER
NV2t003790001.1	cellular_component	GO:0000145	exocyst	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]	OMA
NV2t003790001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003790001.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t003792001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003794001.1	cellular_component	GO:0097524	sperm plasma membrane	"A plasma membrane that is part of a sperm cell." [GOC:cjm]	PANTHER
NV2t003794003.1	cellular_component	GO:0097524	sperm plasma membrane	"A plasma membrane that is part of a sperm cell." [GOC:cjm]	PANTHER
NV2t003794004.1	cellular_component	GO:0097524	sperm plasma membrane	"A plasma membrane that is part of a sperm cell." [GOC:cjm]	PANTHER
NV2t003794005.1	cellular_component	GO:0097524	sperm plasma membrane	"A plasma membrane that is part of a sperm cell." [GOC:cjm]	PANTHER
NV2t003794006.1	cellular_component	GO:0097524	sperm plasma membrane	"A plasma membrane that is part of a sperm cell." [GOC:cjm]	PANTHER
NV2t003795001.1	biological_process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	OMA
NV2t003795001.1	biological_process	GO:0000291	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]	OMA
NV2t003795001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	InterPro
NV2t003795001.1	biological_process	GO:0016078	tRNA decay	"The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai]	OMA
NV2t003795001.1	biological_process	GO:0031125	rRNA 3'-end processing	"Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah]	OMA
NV2t003795001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t003795001.1	biological_process	GO:0043634	polyadenylation-dependent ncRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc]	OMA
NV2t003795001.1	biological_process	GO:0071027	nuclear RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]	OMA
NV2t003795001.1	biological_process	GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	"The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474]	PANTHER
NV2t003795001.1	biological_process	GO:0090503	obsolete RNA phosphodiester bond hydrolysis, exonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	OMA
NV2t003795001.1	cellular_component	GO:0000176	nuclear exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t003795001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003795001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003795001.1	molecular_function	GO:0035925	mRNA 3'-UTR AU-rich region binding	"Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]	OMA
NV2t003795001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t003796001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003796001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t003796001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t003797001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003797002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003797003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003799001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t003800001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	OMA
NV2t003800001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	PANTHER
NV2t003800001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t003800001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t003800001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t003800001.1	molecular_function	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t003801001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003802001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t003802001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t003802002.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t003802002.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t003802002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003802002.1	biological_process	GO:0140747	obsolete regulation of ncRNA transcription	"OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template." [GOC:pg]	OMA
NV2t003802002.1	biological_process	GO:1901582	obsolete positive regulation of telomeric RNA transcription from RNA pol II promoter	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie]	PANTHER
NV2t003802002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003802002.1	cellular_component	GO:0005721	pericentric heterochromatin	"Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3)." [PMID:12019236, PMID:20206496, PMID:21437270, PMID:22729156, PMID:9413993]	OMA
NV2t003802002.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	OMA
NV2t003802002.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t003803001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t003803001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	InterPro
NV2t003803001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	PANTHER
NV2t003803001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t003804001.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	OMA
NV2t003804001.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	PANTHER
NV2t003804001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t003804001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003804001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t003804001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t003804001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t003804002.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	PANTHER
NV2t003804002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003808001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t003808001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t003808001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t003808001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t003808001.1	cellular_component	GO:0000118	histone deacetylase complex	"A protein complex that possesses histone deacetylase activity." [GOC:mah]	OMA
NV2t003808001.1	molecular_function	GO:0004407	histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [PMID:9893272, RHEA:58196]	OMA
NV2t003808002.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t003808002.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t003808003.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t003808004.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t003808005.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t003808005.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t003809001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t003810001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t003810001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003812001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t003812001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t003812001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t003812001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t003812001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t003815001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003815001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003815001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003816001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003816001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t003816001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003816002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003816002.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t003816002.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t003816002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t003816002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t003816002.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t003816002.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t003816002.1	biological_process	GO:0061351	neural precursor cell proliferation	"The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf]	OMA
NV2t003816002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003816002.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t003816002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t003816002.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t003816002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003816002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003817001.1	cellular_component	GO:0140284	endoplasmic reticulum-endosome membrane contact site	"A contact site between the endoplasmic reticulum membrane and the endosome membrane." [PMID:24105263, PMID:30220460]	PANTHER
NV2t003817002.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t003817002.1	cellular_component	GO:0044232	organelle membrane contact site	"A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880]	OMA
NV2t003817002.1	cellular_component	GO:0140284	endoplasmic reticulum-endosome membrane contact site	"A contact site between the endoplasmic reticulum membrane and the endosome membrane." [PMID:24105263, PMID:30220460]	PANTHER
NV2t003817003.1	cellular_component	GO:0140284	endoplasmic reticulum-endosome membrane contact site	"A contact site between the endoplasmic reticulum membrane and the endosome membrane." [PMID:24105263, PMID:30220460]	PANTHER
NV2t003817004.1	cellular_component	GO:0140284	endoplasmic reticulum-endosome membrane contact site	"A contact site between the endoplasmic reticulum membrane and the endosome membrane." [PMID:24105263, PMID:30220460]	PANTHER
NV2t003818001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t003818001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003818001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t003818001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t003819001.1	biological_process	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	OMA
NV2t003819001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t003819001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t003819001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t003819002.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t003820001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t003820001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	OMA
NV2t003820003.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t003820004.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t003821001.1	biological_process	GO:0006195	purine nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003821001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	OMA
NV2t003821001.1	biological_process	GO:0009144	purine nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003821001.1	biological_process	GO:0009151	purine deoxyribonucleotide metabolic process	"The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t003821001.1	biological_process	GO:0016074	sno(s)RNA metabolic process	"The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc]	OMA
NV2t003821001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t003821001.1	biological_process	GO:0051253	negative regulation of RNA metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	OMA
NV2t003821001.1	biological_process	GO:0090068	positive regulation of cell cycle process	"Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t003821001.1	biological_process	GO:0090069	regulation of ribosome biogenesis	"Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]	OMA
NV2t003821001.1	biological_process	GO:0110154	RNA decapping	"Cleavage of the 5'-cap of an RNA." [GOC:sp, PMID:25533955, PMID:31101919]	OMA
NV2t003821001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t003821001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003821001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003821001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t003821001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t003821001.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	OMA
NV2t003821001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t003821001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t003821001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t003821001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t003821001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t003821001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t003821001.1	molecular_function	GO:0047429	nucleoside triphosphate diphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]	OMA
NV2t003821001.1	molecular_function	GO:0050072	obsolete m7G(5')pppN diphosphatase activity	"OBSOLETE. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [GOC:curators]	OMA
NV2t003821001.1	molecular_function	GO:1990003	IDP phosphatase activity	"Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate." [PMID:20385596, PMID:22849572, RHEA:35207]	OMA
NV2t003821001.1	molecular_function	GO:1990174	phosphodiesterase decapping endonuclease activity	"Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA." [GOC:dgf, PMID:20802481]	PANTHER
NV2t003822001.1	molecular_function	GO:0004800	thyroxine 5'-deiodinase activity	"Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.21.99.4]	InterPro
NV2t003823001.1	biological_process	GO:0018022	peptidyl-lysine methylation	"The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]	OMA
NV2t003823001.1	biological_process	GO:0018022	peptidyl-lysine methylation	"The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]	PANTHER
NV2t003823001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003823001.1	molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]	OMA
NV2t003825001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t003825001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t003825001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003827001.1	biological_process	GO:0015850	organic hydroxy compound transport	"The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]	OMA
NV2t003827001.1	biological_process	GO:0030321	transepithelial chloride transport	"The directed movement of chloride ions from one side of an epithelium to the other." [GOC:mah]	OMA
NV2t003827001.1	biological_process	GO:0034219	carbohydrate transmembrane transport	"The process in which a carbohydrate is transported across a membrane." [GOC:mah]	OMA
NV2t003827001.1	biological_process	GO:0034764	positive regulation of transmembrane transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]	OMA
NV2t003827001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t003827001.1	biological_process	GO:0042045	epithelial fluid transport	"The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830]	OMA
NV2t003827001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t003827001.1	biological_process	GO:0046717	acid secretion	"The controlled release of acid by a cell or a tissue." [GOC:ai]	OMA
NV2t003827001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	OMA
NV2t003827001.1	biological_process	GO:0050892	intestinal absorption	"A process in which nutrients are taken up from the contents of the intestine." [GOC:ai, GOC:dph]	OMA
NV2t003827001.1	biological_process	GO:0051454	intracellular pH elevation	"Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]	OMA
NV2t003827001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003827001.1	biological_process	GO:0071320	cellular response to cAMP	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah]	OMA
NV2t003827001.1	biological_process	GO:0071332	cellular response to fructose stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah]	OMA
NV2t003827001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t003827001.1	biological_process	GO:0090087	regulation of peptide transport	"Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	OMA
NV2t003827001.1	cellular_component	GO:0012506	vesicle membrane	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]	OMA
NV2t003827001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003827001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t003827001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t003827001.1	cellular_component	GO:0031526	brush border membrane	"The portion of the plasma membrane surrounding the brush border." [GOC:mah]	OMA
NV2t003827001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t003827001.1	molecular_function	GO:0005452	solute:inorganic anion antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)." [GOC:mah]	OMA
NV2t003827001.1	molecular_function	GO:0015106	bicarbonate transmembrane transporter activity	"Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]	OMA
NV2t003827001.1	molecular_function	GO:0015108	chloride transmembrane transporter activity	"Enables the transfer of chloride ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t003827001.1	molecular_function	GO:0015116	sulfate transmembrane transporter activity	"Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]	OMA
NV2t003827001.1	molecular_function	GO:0015499	formate transmembrane transporter activity	"Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai]	OMA
NV2t003827001.1	molecular_function	GO:0015562	efflux transmembrane transporter activity	"Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003827001.1	molecular_function	GO:0019531	oxalate transmembrane transporter activity	"Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732]	OMA
NV2t003827001.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	OMA
NV2t003827002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003827002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003827003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003827003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003827004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003827004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003827005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003827005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003828001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003828001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t003828001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t003828001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t003828001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003828001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003828002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003828002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t003828002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003829001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t003830001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003830001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t003830001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t003830001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t003830001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003831001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003836001.1	biological_process	GO:0050853	B cell receptor signaling pathway	"The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add]	PANTHER
NV2t003836002.1	biological_process	GO:0050853	B cell receptor signaling pathway	"The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add]	PANTHER
NV2t003836003.1	biological_process	GO:0050853	B cell receptor signaling pathway	"The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add]	PANTHER
NV2t003838001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003838001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t003838001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t003838001.1	biological_process	GO:0010867	positive regulation of triglyceride biosynthetic process	"Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]	OMA
NV2t003838001.1	biological_process	GO:0010893	positive regulation of steroid biosynthetic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb]	OMA
NV2t003838001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t003838001.1	biological_process	GO:0032933	SREBP signaling pathway	"The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871]	OMA
NV2t003838001.1	biological_process	GO:0033157	regulation of intracellular protein transport	"Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah]	OMA
NV2t003838001.1	biological_process	GO:0062013	positive regulation of small molecule metabolic process	"Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t003838001.1	biological_process	GO:1903146	regulation of autophagy of mitochondrion	"Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391]	OMA
NV2t003838001.1	biological_process	GO:2000630	positive regulation of miRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph]	OMA
NV2t003838001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003838001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003838001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003838001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t003838001.1	molecular_function	GO:0001221	transcription coregulator binding	"Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc]	OMA
NV2t003838001.1	molecular_function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	OMA
NV2t003838001.1	molecular_function	GO:0004879	nuclear receptor activity	"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]	OMA
NV2t003838001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003838001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t003839001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003839001.1	biological_process	GO:0010884	positive regulation of lipid storage	"Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t003839001.1	biological_process	GO:0032933	SREBP signaling pathway	"The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871]	OMA
NV2t003839001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003839001.1	biological_process	GO:0046890	regulation of lipid biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	OMA
NV2t003839001.1	biological_process	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t003839001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003839001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t003839001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t003839001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t003839001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003839001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t003839002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003839002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003839003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003839003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t003841001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003841001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003841001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003844001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t003844001.1	cellular_component	GO:0070187	shelterin complex	"A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1." [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880]	PANTHER
NV2t003850001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t003850001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t003850001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t003850001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t003850001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t003851001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t003851001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t003851001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003851001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003851001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t003851001.1	molecular_function	GO:0005388	P-type calcium transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)." [RHEA:18105]	OMA
NV2t003851001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003852001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003857001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003857001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t003857001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t003857001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t003857001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t003857001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t003857001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003857001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003859001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003859001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t003859001.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t003859001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t003859001.1	biological_process	GO:0044344	cellular response to fibroblast growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf]	OMA
NV2t003859001.1	biological_process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t003859001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	OMA
NV2t003859001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t003859001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003859001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t003859001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t003859001.1	molecular_function	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	OMA
NV2t003859001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003859001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003860001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t003860001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t003860001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t003860001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t003860001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t003860001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t003863001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t003863001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t003863001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t003863001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t003863001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t003863001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t003865001.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	OMA
NV2t003865001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t003865001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t003865001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t003865001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t003865001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	PANTHER
NV2t003866001.1	biological_process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]	InterPro
NV2t003866001.1	biological_process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165]	OMA
NV2t003866001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003866001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003870002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003872001.1	molecular_function	GO:1990698	palmitoleoyltransferase activity	"Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." [PMID:17141155, PMID:25731175]	PANTHER
NV2t003872002.1	molecular_function	GO:1990698	palmitoleoyltransferase activity	"Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." [PMID:17141155, PMID:25731175]	PANTHER
NV2t003872003.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t003872003.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t003872003.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	OMA
NV2t003872003.1	biological_process	GO:0061355	Wnt protein secretion	"The controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]	OMA
NV2t003872003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t003872003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003872003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t003872003.1	molecular_function	GO:0017147	Wnt-protein binding	"Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]	OMA
NV2t003872003.1	molecular_function	GO:1990698	palmitoleoyltransferase activity	"Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." [PMID:17141155, PMID:25731175]	PANTHER
NV2t003873001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t003875001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003875001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003875001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003875001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003878001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t003879001.1	biological_process	GO:0001654	eye development	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]	OMA
NV2t003879001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t003879001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t003879001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t003879001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003879001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t003879001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t003879001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t003882001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882001.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882002.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882003.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882004.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882005.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882006.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882007.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882007.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882008.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882008.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882009.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882009.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003882010.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t003882010.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t003883001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t003883001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t003883001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t003883001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t003883001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t003883001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t003883001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t003883001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t003883001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t003885001.1	biological_process	GO:0000902	cell morphogenesis	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t003885001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	OMA
NV2t003885001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	PANTHER
NV2t003885001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t003885001.1	cellular_component	GO:0030427	site of polarized growth	"Any part of a cell where non-isotropic growth takes place." [GOC:mah]	OMA
NV2t003886001.1	biological_process	GO:0006829	zinc ion transport	"The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t003886001.1	biological_process	GO:0006882	intracellular zinc ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t003886001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t003886001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003886001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003886001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t003886001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t003886001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t003886001.1	molecular_function	GO:0008324	monoatomic cation transmembrane transporter activity	"Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t003886001.1	molecular_function	GO:0008324	monoatomic cation transmembrane transporter activity	"Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003886001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t003887001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t003887001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t003887001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t003887001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t003888001.1	biological_process	GO:0030150	protein import into mitochondrial matrix	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]	PANTHER
NV2t003888001.1	cellular_component	GO:0001405	PAM complex, Tim23 associated import motor	"Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix." [GOC:mcc, GOC:vw, PMID:14517234, PMID:14638855]	InterPro
NV2t003888001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t003888001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t003890001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003891001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003893001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t003893001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t003893001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t003893001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t003893001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t003893002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t003893002.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t003893003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t003893003.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t003894001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t003894001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t003899001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003899001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003900001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003900001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t003900001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t003900001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003900001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t003900001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t003901001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003901001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t003901001.1	biological_process	GO:0006032	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t003901001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t003901001.1	molecular_function	GO:0004568	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	OMA
NV2t003901001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t003901001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t003901001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t003902001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t003902001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003902001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t003902001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t003902001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003902001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003902001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003903001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t003903001.1	biological_process	GO:0006429	leucyl-tRNA aminoacylation	"The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t003903002.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t003903002.1	biological_process	GO:0006429	leucyl-tRNA aminoacylation	"The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t003904001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t003904001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003904001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003904001.1	molecular_function	GO:0008417	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t003904001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t003906001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t003906001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003907001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t003907001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t003907001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003907001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t003907001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003909001.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t003909001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003909001.1	molecular_function	GO:0004089	carbonate dehydratase activity	"Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O." [EC:4.2.1.1]	OMA
NV2t003909001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003909001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003911001.1	molecular_function	GO:0051059	NF-kappaB binding	"Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]	PANTHER
NV2t003911002.1	biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]	OMA
NV2t003911002.1	molecular_function	GO:0051059	NF-kappaB binding	"Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]	OMA
NV2t003911002.1	molecular_function	GO:0051059	NF-kappaB binding	"Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]	PANTHER
NV2t003912001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	OMA
NV2t003912001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t003912001.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	OMA
NV2t003912001.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	PANTHER
NV2t003912001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003912001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003912001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t003914001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t003914001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t003914001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003914001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t003915001.1	molecular_function	GO:0003856	3-dehydroquinate synthase activity	"Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21968]	PANTHER
NV2t003915001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t003918001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003918001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t003922001.1	biological_process	GO:0006097	glyoxylate cycle	"A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732]	InterPro
NV2t003922001.1	biological_process	GO:0006097	glyoxylate cycle	"A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732]	PANTHER
NV2t003922001.1	biological_process	GO:0044262	obsolete cellular carbohydrate metabolic process	"OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t003922001.1	biological_process	GO:0046487	glyoxylate metabolic process	"The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]	OMA
NV2t003922001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t003922001.1	molecular_function	GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	OMA
NV2t003925001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t003925001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t003925001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t003925001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t003925001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t003925001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t003925001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t003926001.1	cellular_component	GO:0031415	NatA complex	"A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471]	PANTHER
NV2t003926001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003927001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t003927001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	InterPro
NV2t003927001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t003927001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t003927001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003927001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003927001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t003927002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t003927002.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	InterPro
NV2t003927002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t003927002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003928001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003928001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003928001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t003928002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003928002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t003928002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t003928002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t003931001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t003932001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	OMA
NV2t003932001.1	biological_process	GO:0071786	endoplasmic reticulum tubular network organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	OMA
NV2t003932001.1	biological_process	GO:0071786	endoplasmic reticulum tubular network organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	PANTHER
NV2t003932001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t003932001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003932002.1	biological_process	GO:0071786	endoplasmic reticulum tubular network organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	PANTHER
NV2t003932002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003933001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t003933001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	PANTHER
NV2t003933001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t003933001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t003933001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t003933001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t003934002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003937001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t003937001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t003937001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t003937001.1	biological_process	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	OMA
NV2t003937001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003937001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003937001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t003937001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t003937001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t003939001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t003939001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003939001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003939001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003939001.1	molecular_function	GO:0004984	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	OMA
NV2t003941001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t003941001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t003941001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003941001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t003943001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t003944001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t003944001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t003944001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t003945001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t003945001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t003945001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003945001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t003946001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003946002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003950001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003950001.1	molecular_function	GO:0051019	mitogen-activated protein kinase binding	"Binding to a mitogen-activated protein kinase." [GOC:ai]	PANTHER
NV2t003950002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003950002.1	molecular_function	GO:0051019	mitogen-activated protein kinase binding	"Binding to a mitogen-activated protein kinase." [GOC:ai]	PANTHER
NV2t003950003.1	biological_process	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	OMA
NV2t003950003.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t003950003.1	biological_process	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	OMA
NV2t003950003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003950003.1	biological_process	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	OMA
NV2t003950003.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t003950003.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t003950003.1	biological_process	GO:0032496	response to lipopolysaccharide	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464]	OMA
NV2t003950003.1	biological_process	GO:0034097	response to cytokine	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]	OMA
NV2t003950003.1	biological_process	GO:0044351	macropinocytosis	"An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size." [PMID:14732047]	OMA
NV2t003950003.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t003950003.1	biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t003950003.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t003950003.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t003950003.1	biological_process	GO:0070935	3'-UTR-mediated mRNA stabilization	"An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303]	OMA
NV2t003950003.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	OMA
NV2t003950003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003950003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t003950003.1	molecular_function	GO:0004683	calmodulin-dependent protein kinase activity	"Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah, PMID:11264466]	OMA
NV2t003950003.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t003950003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003950003.1	molecular_function	GO:0051019	mitogen-activated protein kinase binding	"Binding to a mitogen-activated protein kinase." [GOC:ai]	OMA
NV2t003950003.1	molecular_function	GO:0051019	mitogen-activated protein kinase binding	"Binding to a mitogen-activated protein kinase." [GOC:ai]	PANTHER
NV2t003950004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003950004.1	molecular_function	GO:0051019	mitogen-activated protein kinase binding	"Binding to a mitogen-activated protein kinase." [GOC:ai]	PANTHER
NV2t003951001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003951002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t003952001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t003952001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t003952002.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t003952003.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t003953001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t003953001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t003953001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t003953001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t003953001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t003953001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003953001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003954001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t003955001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t003955001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003955001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003955001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t003958001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t003958001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t003958001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t003958001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t003958001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t003967001.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	InterPro
NV2t003967001.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t003967001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003967002.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	InterPro
NV2t003967002.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t003967003.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	InterPro
NV2t003967003.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	OMA
NV2t003967003.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t003967003.1	cellular_component	GO:0005968	Rab-protein geranylgeranyltransferase complex	"An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein)." [GOC:jl, PMID:11886217]	OMA
NV2t003967003.1	molecular_function	GO:0004663	Rab geranylgeranyltransferase activity	"Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375]	OMA
NV2t003967003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003967003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003967004.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	InterPro
NV2t003967004.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t003967004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003968001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t003968001.1	biological_process	GO:0045332	phospholipid translocation	"The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]	OMA
NV2t003968001.1	biological_process	GO:0045332	phospholipid translocation	"The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]	PANTHER
NV2t003968001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t003968001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t003969001.1	biological_process	GO:0042078	germ-line stem cell division	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]	PANTHER
NV2t003969001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003969001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003969002.1	biological_process	GO:0042078	germ-line stem cell division	"The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]	PANTHER
NV2t003969002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003971001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t003971001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t003971001.1	biological_process	GO:0015804	neutral amino acid transport	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t003971001.1	biological_process	GO:0072337	modified amino acid transport	"The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t003971001.1	biological_process	GO:0072348	sulfur compound transport	"The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t003971001.1	biological_process	GO:1902475	L-alpha-amino acid transmembrane transport	"The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore." [GOC:kmv, GOC:TermGenie, PMID:14668347]	OMA
NV2t003971001.1	cellular_component	GO:0031526	brush border membrane	"The portion of the plasma membrane surrounding the brush border." [GOC:mah]	OMA
NV2t003971001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003972001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t003972001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t003972001.1	molecular_function	GO:0008276	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]	OMA
NV2t003972001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t003972001.1	molecular_function	GO:0106370	protein-L-histidine N-pros-methyltransferase activity	"Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine." [PMID:33563959, RHEA:67076]	InterPro
NV2t003973001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t003974001.1	biological_process	GO:0000460	maturation of 5.8S rRNA	"Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators]	PANTHER
NV2t003974001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t003974001.1	cellular_component	GO:0000178	exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t003974001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003976001.1	biological_process	GO:0035249	synaptic transmission, glutamatergic	"The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]	OMA
NV2t003976001.1	biological_process	GO:0050804	modulation of chemical synaptic transmission	"Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]	OMA
NV2t003976001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003976001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t003976001.1	molecular_function	GO:0008066	glutamate receptor activity	"Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]	OMA
NV2t003976001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t003976001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t003976001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t003977001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003977002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003977003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003977004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003977005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003980001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t003980001.1	cellular_component	GO:0016272	prefoldin complex	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]	OMA
NV2t003980001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t003981001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003981001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t003981001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t003981001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	PANTHER
NV2t003981001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t003981001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t003982001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t003982001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t003982001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t003982001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t003983001.1	cellular_component	GO:0099078	BORC complex	"A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167]	PANTHER
NV2t003984001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t003984001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t003984001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t003984001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t003985001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t003985001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	OMA
NV2t003985001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t003985001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t003985001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t003985001.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	OMA
NV2t003985001.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	PANTHER
NV2t003985001.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t003985001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003985001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t003985001.1	molecular_function	GO:0004347	glucose-6-phosphate isomerase activity	"Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9]	OMA
NV2t003985001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t003985001.1	molecular_function	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	OMA
NV2t003987001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003987001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t003987003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003987003.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t003987004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t003987004.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t003988001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t003988001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t003988001.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	OMA
NV2t003988001.1	molecular_function	GO:0070840	dynein complex binding	"Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]	OMA
NV2t003988001.1	molecular_function	GO:0070840	dynein complex binding	"Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]	PANTHER
NV2t003989001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t003989001.1	biological_process	GO:2000177	regulation of neural precursor cell proliferation	"Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]	OMA
NV2t003989001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t003990001.1	biological_process	GO:0035617	stress granule disassembly	"The disaggregation of a stress granule into its constituent protein and RNA parts." [GOC:BHF, PMID:19825938]	OMA
NV2t003990001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t003990001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t003990001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003990001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t003991001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	OMA
NV2t003991001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	PANTHER
NV2t003991001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t003991001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t003991001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t003991001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t003993001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003993001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t003993002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t003993002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t003993002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t003994001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	PANTHER
NV2t003995001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t003995001.1	molecular_function	GO:0008137	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out)." [RHEA:29091]	InterPro
NV2t003995001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t003995002.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t003995002.1	molecular_function	GO:0008137	NADH dehydrogenase (ubiquinone) activity	"Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out)." [RHEA:29091]	InterPro
NV2t003995002.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t003998001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	InterPro
NV2t003998001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	OMA
NV2t003999001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t003999001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t003999001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t003999001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004000001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t004003001.1	biological_process	GO:0035249	synaptic transmission, glutamatergic	"The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]	OMA
NV2t004003001.1	biological_process	GO:0050804	modulation of chemical synaptic transmission	"Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]	OMA
NV2t004003001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004003001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t004003001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t004003001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t004003001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t004004001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t004004001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	PANTHER
NV2t004004001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t004004001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004004001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004004001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004005001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004005001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	PANTHER
NV2t004006001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t004007001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	PANTHER
NV2t004007001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004007001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004007001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004007002.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	PANTHER
NV2t004007002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004008001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	PANTHER
NV2t004008001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004008001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004008001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004009001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t004009001.1	molecular_function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	"Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai]	PANTHER
NV2t004011001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004011001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t004013001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t004013001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t004013001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	OMA
NV2t004013001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	PANTHER
NV2t004013001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004013001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t004014001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004014001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004014001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004021001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004021001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004021001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t004021001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004021001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t004021002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004021002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t004021002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004021003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004021003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t004021003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004025001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004025001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t004025002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004025002.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t004026001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004026001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t004026001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t004028001.1	biological_process	GO:0006693	prostaglandin metabolic process	"The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]	OMA
NV2t004028001.1	biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]	OMA
NV2t004028001.1	biological_process	GO:0030728	ovulation	"The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437]	OMA
NV2t004028001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t004028001.1	biological_process	GO:0044703	multi-organism reproductive process	"A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl]	OMA
NV2t004028001.1	biological_process	GO:0044706	multi-multicellular organism process	"A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl]	OMA
NV2t004028001.1	biological_process	GO:0045786	negative regulation of cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t004028001.1	biological_process	GO:0050994	regulation of lipid catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]	OMA
NV2t004028001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t004028001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004028001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004028001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t004028001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t004028001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t004028001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t004028001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t004030001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t004030001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t004032001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t004032001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004032001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004032001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004032001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	OMA
NV2t004033001.1	biological_process	GO:0033299	secretion of lysosomal enzymes	"The controlled release of lysosomal enzymes by a cell." [GOC:mah]	PANTHER
NV2t004034001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t004034001.1	biological_process	GO:0033299	secretion of lysosomal enzymes	"The controlled release of lysosomal enzymes by a cell." [GOC:mah]	PANTHER
NV2t004036001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	InterPro
NV2t004036001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t004036001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t004036001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004036001.1	cellular_component	GO:0031501	mannosyltransferase complex	"A complex that posseses mannosyltransferase activity." [GOC:mah]	OMA
NV2t004036001.1	cellular_component	GO:0033185	dolichol-phosphate-mannose synthase complex	"A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346]	PANTHER
NV2t004037001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004037001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004038001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t004039001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t004039001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t004039001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004039001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t004039001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t004039002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004039002.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t004040001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t004040001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t004040001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t004040001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004040001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t004040002.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t004040002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004040003.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t004040003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004040004.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t004040004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004040005.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t004040005.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004041001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004041001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004041001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t004041001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t004041001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t004041001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004041001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004042001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t004042001.1	biological_process	GO:0019673	GDP-mannose metabolic process	"The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	InterPro
NV2t004042001.1	biological_process	GO:0019673	GDP-mannose metabolic process	"The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	PANTHER
NV2t004042001.1	biological_process	GO:0042351	'de novo' GDP-L-fucose biosynthetic process	"The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [PMID:11030750]	OMA
NV2t004042001.1	molecular_function	GO:0008446	GDP-mannose 4,6-dehydratase activity	"Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O." [EC:4.2.1.47, RHEA:23820]	OMA
NV2t004042001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t004042001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t004042002.1	biological_process	GO:0019673	GDP-mannose metabolic process	"The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	InterPro
NV2t004042002.1	biological_process	GO:0019673	GDP-mannose metabolic process	"The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	PANTHER
NV2t004044001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t004044001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t004044001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004044001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t004044001.1	molecular_function	GO:0008139	nuclear localization sequence binding	"Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai]	OMA
NV2t004044001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t004044001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t004044001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t004044001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t004045001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004045001.1	cellular_component	GO:0046658	obsolete anchored component of plasma membrane	"OBSOLETE. The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]	PANTHER
NV2t004045001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t004045002.1	cellular_component	GO:0046658	obsolete anchored component of plasma membrane	"OBSOLETE. The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah]	PANTHER
NV2t004046001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004046001.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t004046001.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	PANTHER
NV2t004046002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004046002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t004046002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004046002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004046002.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t004046002.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	PANTHER
NV2t004046002.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t004046003.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t004046003.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	PANTHER
NV2t004046004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004046004.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t004046004.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	PANTHER
NV2t004047001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t004048001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	InterPro
NV2t004048001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t004048001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004048001.1	molecular_function	GO:0019838	growth factor binding	"Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators]	OMA
NV2t004048002.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	InterPro
NV2t004048002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004051001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	PANTHER
NV2t004052001.1	biological_process	GO:0006991	response to sterol depletion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732]	OMA
NV2t004052001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t004052001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	OMA
NV2t004052001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t004052001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t004052001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	PANTHER
NV2t004052001.1	biological_process	GO:0070070	proton-transporting V-type ATPase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient." [GOC:mah]	OMA
NV2t004052001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t004052001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t004052001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t004052001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004052001.1	cellular_component	GO:0030670	phagocytic vesicle membrane	"The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah]	OMA
NV2t004052001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t004052001.1	molecular_function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]	OMA
NV2t004052001.1	molecular_function	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	"Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah]	OMA
NV2t004055001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t004055001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004056001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t004056001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004056002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t004056002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004056003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t004056003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004056004.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t004056004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004058001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t004058001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004060002.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t004060003.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t004061001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t004061001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004062001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t004063001.1	biological_process	GO:0007586	digestion	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]	OMA
NV2t004063001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t004063001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t004063001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t004063001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t004064001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004064001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t004064001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004065001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t004065001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t004065001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t004065002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t004065003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t004066001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t004066001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004066002.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t004066002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004066003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004067001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t004067001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t004067001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t004075001.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075002.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075003.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075004.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075005.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075006.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075007.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075008.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075009.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004075010.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	PANTHER
NV2t004076001.1	biological_process	GO:0009132	nucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t004076001.1	biological_process	GO:0009154	purine ribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t004076001.1	biological_process	GO:0015938	coenzyme A catabolic process	"The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	PANTHER
NV2t004076001.1	biological_process	GO:0034031	ribonucleoside bisphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t004076001.1	biological_process	GO:0034034	purine nucleoside bisphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t004076001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t004076001.1	molecular_function	GO:0010945	coenzyme A diphosphatase activity	"Catalysis of the reaction:an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine. This reaction can also use coenzyme A as a substrate." [PMID:10922370, PMID:16185196, RHEA:50044]	InterPro
NV2t004076001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t004076001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t004076001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t004077001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t004077001.1	biological_process	GO:0006858	extracellular transport	"The transport of substances that occurs outside cells." [GOC:go_curators]	OMA
NV2t004077001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t004077001.1	biological_process	GO:0032410	negative regulation of transporter activity	"Any process that stops or reduces the activity of a transporter." [GOC:mah]	OMA
NV2t004077001.1	biological_process	GO:0042391	regulation of membrane potential	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]	OMA
NV2t004077001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t004077001.1	biological_process	GO:0043433	negative regulation of DNA-binding transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]	OMA
NV2t004077001.1	biological_process	GO:0051224	negative regulation of protein transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t004077001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	OMA
NV2t004077001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t004077001.1	biological_process	GO:1901016	regulation of potassium ion transmembrane transporter activity	"Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]	OMA
NV2t004077001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004077001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004077001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t004077001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004077001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t004077001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t004077001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t004077001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t004077002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t004077002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004077002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t004077002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t004077003.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t004077003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004077003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t004077003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t004079001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004079001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t004079001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t004079001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t004080001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t004080001.1	cellular_component	GO:0000118	histone deacetylase complex	"A protein complex that possesses histone deacetylase activity." [GOC:mah]	OMA
NV2t004080001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t004080001.1	cellular_component	GO:0000812	Swr1 complex	"A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820]	PANTHER
NV2t004080001.1	cellular_component	GO:0097346	INO80-type complex	"A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820]	OMA
NV2t004083001.1	biological_process	GO:0090527	obsolete actin filament reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments." [GOC:dph, GOC:tb]	PANTHER
NV2t004083001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004083002.1	biological_process	GO:0090527	obsolete actin filament reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments." [GOC:dph, GOC:tb]	PANTHER
NV2t004083002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004084001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004084001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004084001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004085001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t004085001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t004085001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t004085001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t004085001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t004087001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004087001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t004087001.1	molecular_function	GO:0008324	monoatomic cation transmembrane transporter activity	"Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004088001.1	biological_process	GO:0006998	nuclear envelope organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]	OMA
NV2t004088001.1	biological_process	GO:0051292	nuclear pore complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah]	OMA
NV2t004088001.1	biological_process	GO:0071786	endoplasmic reticulum tubular network organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	OMA
NV2t004088001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t004088001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004089001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004089001.1	biological_process	GO:0097037	heme export	"The directed movement of heme out of a cell or organelle." [GOC:lf, PMID:15369674, PMID:20610401]	PANTHER
NV2t004089001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004092001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t004092001.1	biological_process	GO:0035522	obsolete monoubiquitinated histone H2A deubiquitination	"OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]	OMA
NV2t004092001.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	OMA
NV2t004092001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t004092001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t004092001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t004092001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t004092001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004092001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004092001.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	OMA
NV2t004092001.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	PANTHER
NV2t004092001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t004092002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t004092002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004092002.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	PANTHER
NV2t004092003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t004092003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004092003.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	PANTHER
NV2t004093001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004093001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t004096001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t004096001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004096002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t004096002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004097001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t004097001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t004097001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t004097001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t004097001.1	molecular_function	GO:0102009	proline dipeptidase activity	"Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal = L-proline + a standard alpha amino acid." [EC:3.4.13.9]	OMA
NV2t004097002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t004098001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004098001.1	cellular_component	GO:0044441	obsolete ciliary part	"OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t004101001.1	biological_process	GO:0000054	ribosomal subunit export from nucleus	"The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t004101001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t004101001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t004101001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t004101001.1	biological_process	GO:0035195	miRNA-mediated post-transcriptional gene silencing	"A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants." [GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604]	OMA
NV2t004101001.1	biological_process	GO:0042256	cytosolic ribosome assembly	"The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol." [GOC:ma, PMID:30467428]	OMA
NV2t004101001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t004101001.1	biological_process	GO:1902626	assembly of large subunit precursor of preribosome	"The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:22735702]	PANTHER
NV2t004101001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t004101001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004101001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t004101001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	InterPro
NV2t004101001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t004103001.1	biological_process	GO:0006885	regulation of pH	"Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t004103001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004103001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t004103001.1	molecular_function	GO:0015385	sodium:proton antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]	OMA
NV2t004105001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004107001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004107002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004108001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t004108001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t004108001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t004108001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t004108001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t004109001.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t004109001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004109002.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t004109002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004109003.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t004109003.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t004109003.1	biological_process	GO:0110053	regulation of actin filament organization	"Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv]	OMA
NV2t004109003.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t004109003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004109004.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t004109004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004110001.1	biological_process	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	InterPro
NV2t004110001.1	biological_process	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	OMA
NV2t004110001.1	molecular_function	GO:0008428	ribonuclease inhibitor activity	"Binds to and stops, prevents or reduces the activity of ribonuclease." [GOC:ai]	OMA
NV2t004110001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t004110002.1	biological_process	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	InterPro
NV2t004113001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t004114001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004116001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004116001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004116001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004116001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t004117001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t004119001.1	cellular_component	GO:0097422	tubular endosome	"A network of fine tubules in the vicinity of the Golgi complex and around the centriole." [NIF_Subcellular:sao1570660411, NIF_Subcellular:sao694815499, PMID:11896161]	PANTHER
NV2t004119001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004121001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t004121001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004123001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t004123001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t004123001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t004124001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t004124001.1	cellular_component	GO:0042470	melanosome	"A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]	PANTHER
NV2t004124001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004126001.1	biological_process	GO:0010867	positive regulation of triglyceride biosynthetic process	"Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]	OMA
NV2t004126001.1	biological_process	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	OMA
NV2t004126001.1	biological_process	GO:0035304	regulation of protein dephosphorylation	"Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	OMA
NV2t004126001.1	biological_process	GO:0035306	positive regulation of dephosphorylation	"Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]	OMA
NV2t004126001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004126001.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t004126001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t004126001.1	cellular_component	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network	"The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]	OMA
NV2t004126001.1	cellular_component	GO:0071595	Nem1-Spo7 phosphatase complex	"A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p." [GOC:mah, PMID:9822591]	InterPro
NV2t004126001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t004127001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t004127001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	OMA
NV2t004127001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t004127001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t004127001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	InterPro
NV2t004127001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	PANTHER
NV2t004129001.1	biological_process	GO:0060078	regulation of postsynaptic membrane potential	"Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef]	OMA
NV2t004129001.1	biological_process	GO:0099565	chemical synaptic transmission, postsynaptic	"The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos]	OMA
NV2t004129001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004129001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004129001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t004129001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t004129001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t004130001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004131001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004131001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004132001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004132001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004132001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t004134001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t004134001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t004134001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t004134001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t004134001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t004134001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004135001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	OMA
NV2t004135001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t004135001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t004135001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t004135001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t004135001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t004135001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004137001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t004137001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t004137001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	OMA
NV2t004137001.1	biological_process	GO:0007080	mitotic metaphase chromosome alignment	"A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [ISBN:0815316194]	OMA
NV2t004137001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t004137001.1	biological_process	GO:0010824	regulation of centrosome duplication	"Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]	OMA
NV2t004137001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t004137001.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t004137001.1	biological_process	GO:0031468	nuclear membrane reassembly	"The reformation of the nuclear membranes following their breakdown in the context of a normal process." [GOC:mah]	OMA
NV2t004137001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t004137001.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t004137001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t004137001.1	biological_process	GO:0044000	obsolete movement in host	"OBSOLETE. The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]	OMA
NV2t004137001.1	biological_process	GO:0045324	late endosome to vacuole transport	"The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]	PANTHER
NV2t004137001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t004137001.1	biological_process	GO:0061952	midbody abscission	"The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells." [PMID:12737809, PMID:29903934]	OMA
NV2t004137001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t004137001.1	biological_process	GO:1901673	regulation of mitotic spindle assembly	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]	OMA
NV2t004137001.1	biological_process	GO:1902774	late endosome to lysosome transport	"The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442]	OMA
NV2t004137001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t004137001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t004137001.1	cellular_component	GO:0000794	condensed nuclear chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]	OMA
NV2t004137001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t004137001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t004137001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t004137001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t004137001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t004137001.1	cellular_component	GO:0005828	kinetochore microtubule	"Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]	OMA
NV2t004137001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004137001.1	cellular_component	GO:0016363	nuclear matrix	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]	OMA
NV2t004137001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t004137001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t004137001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t004137001.1	cellular_component	GO:0044753	amphisome	"Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]	OMA
NV2t004137001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t004137001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t004137001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t004138001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t004138001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t004138001.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t004138001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004138001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t004138001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004138001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004138001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t004138001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004138001.1	molecular_function	GO:1990446	U1 snRNP binding	"Binding to a U1 small nuclear ribonucleoprotein particle." [PMID:14713954]	PANTHER
NV2t004139001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t004139001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004139001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t004141001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t004141001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004141001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t004142001.1	biological_process	GO:1903457	lactate catabolic process	"The chemical reactions and pathways resulting in the breakdown of lactate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:8941775]	PANTHER
NV2t004142001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t004142001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t004142002.1	biological_process	GO:0072329	monocarboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t004142002.1	biological_process	GO:1901616	organic hydroxy compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t004142002.1	biological_process	GO:1903457	lactate catabolic process	"The chemical reactions and pathways resulting in the breakdown of lactate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:8941775]	PANTHER
NV2t004142002.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t004142002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t004142002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t004142002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t004142002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t004146001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t004146001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t004146001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t004147001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t004147001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t004147001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t004147001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t004147001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t004147001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t004148001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004148002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t004148002.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004148002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004148002.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t004148002.1	molecular_function	GO:0004298	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t004148002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004148003.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004148004.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004148005.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004149001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t004149001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t004149002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t004149002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t004150001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	InterPro
NV2t004150001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t004150001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t004150001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004152001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t004152001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	PANTHER
NV2t004152001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	OMA
NV2t004152001.1	biological_process	GO:0033363	secretory granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]	OMA
NV2t004152001.1	biological_process	GO:0048490	anterograde synaptic vesicle transport	"The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg]	OMA
NV2t004152001.1	biological_process	GO:2000300	regulation of synaptic vesicle exocytosis	"Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]	OMA
NV2t004152001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004152001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t004152001.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	OMA
NV2t004152001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t004157001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004157001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t004157002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004157002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004157002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t004157002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t004162001.1	cellular_component	GO:0097134	cyclin E1-CDK2 complex	"A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]	PANTHER
NV2t004162002.1	cellular_component	GO:0097134	cyclin E1-CDK2 complex	"A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619]	PANTHER
NV2t004163002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t004165001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004165001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t004165001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t004165001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004166001.1	molecular_function	GO:0019212	phosphatase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a phosphatase." [GOC:ai]	PANTHER
NV2t004166002.1	molecular_function	GO:0019212	phosphatase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a phosphatase." [GOC:ai]	PANTHER
NV2t004167001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004170001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t004170001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t004170001.1	biological_process	GO:0006268	DNA unwinding involved in DNA replication	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]	OMA
NV2t004170001.1	biological_process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	"Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]	OMA
NV2t004170001.1	biological_process	GO:1902680	positive regulation of RNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	OMA
NV2t004170001.1	cellular_component	GO:0000811	GINS complex	"A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]	OMA
NV2t004170001.1	cellular_component	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	OMA
NV2t004170001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t004171001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t004171001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t004171001.1	biological_process	GO:0007035	vacuolar acidification	"Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]	OMA
NV2t004171001.1	biological_process	GO:0036296	response to increased oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al]	OMA
NV2t004171001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t004171001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t004171001.1	biological_process	GO:0071453	cellular response to oxygen levels	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah]	OMA
NV2t004171001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t004171001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t004171001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t004171001.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t004171001.1	cellular_component	GO:0033181	plasma membrane proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]	OMA
NV2t004171001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004171001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	InterPro
NV2t004171001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t004171002.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t004171002.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	InterPro
NV2t004171003.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t004171003.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	InterPro
NV2t004174001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t004174001.1	biological_process	GO:0030150	protein import into mitochondrial matrix	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]	InterPro
NV2t004174001.1	biological_process	GO:0030150	protein import into mitochondrial matrix	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]	PANTHER
NV2t004174001.1	biological_process	GO:0044743	protein transmembrane import into intracellular organelle	"The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]	OMA
NV2t004174001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t004174001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t004174001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t004177001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004178001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t004178001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t004178001.1	biological_process	GO:0006997	nucleus organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]	OMA
NV2t004178001.1	biological_process	GO:0007033	vacuole organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]	OMA
NV2t004178001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t004178001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t004178001.1	biological_process	GO:0010256	endomembrane system organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm]	OMA
NV2t004178001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t004178001.1	biological_process	GO:0032984	protein-containing complex disassembly	"The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah]	OMA
NV2t004178001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t004178001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t004178001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	OMA
NV2t004178001.1	biological_process	GO:0072666	establishment of protein localization to vacuole	"The directed movement of a protein to a specific location in a vacuole." [GOC:mah]	OMA
NV2t004178001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t004178001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004178001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004178001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t004178001.1	molecular_function	GO:0140603	obsolete ATP hydrolysis activity	"OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [GOC:curators]	PANTHER
NV2t004181001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t004181001.1	molecular_function	GO:0047560	3-dehydrosphinganine reductase activity	"Catalysis of the reaction: NADP+ + sphinganine = 3-dehydrosphinganine + H+ + NADPH." [EC:1.1.1.102, RHEA:22640]	InterPro
NV2t004181001.1	molecular_function	GO:0047560	3-dehydrosphinganine reductase activity	"Catalysis of the reaction: NADP+ + sphinganine = 3-dehydrosphinganine + H+ + NADPH." [EC:1.1.1.102, RHEA:22640]	PANTHER
NV2t004182001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t004182001.1	biological_process	GO:0018206	peptidyl-methionine modification	"The modification of peptidyl-methionine." [GOC:go_curators]	OMA
NV2t004182001.1	biological_process	GO:0031365	N-terminal protein amino acid modification	"The alteration of the N-terminal amino acid residue in a protein." [GOC:mah]	OMA
NV2t004182001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004182001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t004182001.1	molecular_function	GO:0042586	peptide deformylase activity	"Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl]	InterPro
NV2t004187001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	PANTHER
NV2t004187001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004188001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004188001.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	OMA
NV2t004188001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004188001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	OMA
NV2t004188001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t004190001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	InterPro
NV2t004190001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t004190001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004190001.1	molecular_function	GO:0017147	Wnt-protein binding	"Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]	OMA
NV2t004191001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t004191001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t004191001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004191001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004193001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004193001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004193002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004193002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004193003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004193003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004193004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004193004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004194001.1	molecular_function	GO:0004800	thyroxine 5'-deiodinase activity	"Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.21.99.4]	InterPro
NV2t004199001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004199001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004202001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t004202001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	InterPro
NV2t004202001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	PANTHER
NV2t004202001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t004203001.1	biological_process	GO:0032218	riboflavin transport	"The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]	InterPro
NV2t004203001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004203001.1	molecular_function	GO:0032217	riboflavin transmembrane transporter activity	"Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]	OMA
NV2t004204001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t004204001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t004204002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t004206001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	InterPro
NV2t004206001.1	molecular_function	GO:0033204	ribonuclease P RNA binding	"Binding to RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963]	InterPro
NV2t004207001.1	biological_process	GO:0008300	isoprenoid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t004207001.1	biological_process	GO:0016119	carotene metabolic process	"The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684]	OMA
NV2t004207001.1	biological_process	GO:0042574	retinal metabolic process	"The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [ISBN:0198506732]	OMA
NV2t004207001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004207001.1	molecular_function	GO:0010436	carotenoid dioxygenase activity	"Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333]	OMA
NV2t004207001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	InterPro
NV2t004209001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004209001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004209001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t004209002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004209002.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t004212001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t004212001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t004212001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t004212001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t004212001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t004212001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004212001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004212001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004212001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004214001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t004214001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004214001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t004214001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t004214001.1	molecular_function	GO:0005483	soluble NSF attachment protein activity	"Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857]	OMA
NV2t004214001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004214001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t004215001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t004216001.1	biological_process	GO:0032273	positive regulation of protein polymerization	"Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	OMA
NV2t004216001.1	biological_process	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	InterPro
NV2t004216001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t004217001.1	biological_process	GO:0007051	spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]	OMA
NV2t004217001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	OMA
NV2t004217001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t004217001.1	biological_process	GO:0033566	gamma-tubulin complex localization	"Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t004217001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t004217001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004218001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t004218001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t004218001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t004218001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t004221001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t004221001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t004221001.1	biological_process	GO:0006419	alanyl-tRNA aminoacylation	"The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t004221001.1	biological_process	GO:0006419	alanyl-tRNA aminoacylation	"The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t004221001.1	biological_process	GO:0043039	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	InterPro
NV2t004221001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t004221001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004221001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t004221001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t004221001.1	molecular_function	GO:0002161	aminoacyl-tRNA editing activity	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]	OMA
NV2t004221001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004221001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t004221001.1	molecular_function	GO:0004813	alanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7]	InterPro
NV2t004221001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004221001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t004221001.1	molecular_function	GO:0045182	translation regulator activity	"Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]	OMA
NV2t004224001.1	biological_process	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	OMA
NV2t004224001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t004224001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004224001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004224001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t004224001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t004224001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t004224001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t004224001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t004225001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004226001.1	biological_process	GO:0006084	acetyl-CoA metabolic process	"The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]	OMA
NV2t004226001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t004226001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t004226001.1	biological_process	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	"The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]	InterPro
NV2t004226001.1	biological_process	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	"The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]	PANTHER
NV2t004226001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004226001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004226001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004226001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	InterPro
NV2t004226001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t004226002.1	biological_process	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	"The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]	InterPro
NV2t004226002.1	biological_process	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	"The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]	PANTHER
NV2t004226002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004226002.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	InterPro
NV2t004227001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t004227001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004227002.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t004227002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004227003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t004227003.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t004227003.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004227003.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t004227004.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t004227004.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004228001.1	biological_process	GO:0032147	activation of protein kinase activity	"Any process that initiates the activity of an inactive protein kinase." [GOC:mah]	OMA
NV2t004228001.1	biological_process	GO:0060236	regulation of mitotic spindle organization	"Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t004228001.1	biological_process	GO:0060236	regulation of mitotic spindle organization	"Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t004228001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t004228001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t004231001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t004231001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t004231001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004231001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t004231001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t004231001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t004231001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t004231001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t004231001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t004231001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t004232001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004232001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004233001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t004233001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t004233001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004233001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t004233001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t004233001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t004233001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t004233001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t004233001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t004233001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t004235001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t004235001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004236001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004236001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t004236001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004237001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004237001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t004237001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004238001.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t004238001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004238002.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t004238002.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	OMA
NV2t004238002.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t004238002.1	cellular_component	GO:0005575	cellular_component	"A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt]	OMA
NV2t004238002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t004238002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004238002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004239001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004239001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004240001.1	biological_process	GO:0009089	lysine biosynthetic process via diaminopimelate	"The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]	PANTHER
NV2t004240001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t004240002.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	InterPro
NV2t004240002.1	biological_process	GO:0009089	lysine biosynthetic process via diaminopimelate	"The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]	PANTHER
NV2t004240002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t004240003.1	biological_process	GO:0006553	lysine metabolic process	"The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]	OMA
NV2t004240003.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	InterPro
NV2t004240003.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t004240003.1	biological_process	GO:0009089	lysine biosynthetic process via diaminopimelate	"The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]	PANTHER
NV2t004240003.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t004240003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t004240003.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t004241001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004241001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004241002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004241002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004241003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004241003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004241003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t004241004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004241004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004243001.1	cellular_component	GO:0071007	U2-type catalytic step 2 spliceosome	"A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t004243001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004243001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004243001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004243001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t004249001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t004249001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004249001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t004249001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t004249001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t004249001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t004249001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t004250001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004250001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t004251001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004251001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004251001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004252003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004252003.1	biological_process	GO:1903013	response to differentiation-inducing factor 1	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]	PANTHER
NV2t004252004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004252004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t004252004.1	biological_process	GO:1903013	response to differentiation-inducing factor 1	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]	PANTHER
NV2t004252004.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t004252004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004252005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004252005.1	biological_process	GO:1903013	response to differentiation-inducing factor 1	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]	PANTHER
NV2t004252006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004252006.1	biological_process	GO:1903013	response to differentiation-inducing factor 1	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]	PANTHER
NV2t004252007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004252007.1	biological_process	GO:1903013	response to differentiation-inducing factor 1	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]	PANTHER
NV2t004252008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004252008.1	biological_process	GO:1903013	response to differentiation-inducing factor 1	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]	PANTHER
NV2t004253001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004253001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t004253002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004253002.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t004253003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004253003.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t004255001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	PANTHER
NV2t004255001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t004256001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t004257001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t004257001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t004257001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t004257001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004257001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t004257001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004257001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t004257001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004257001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004258001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t004258001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t004258001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t004258001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004258001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t004258001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004258001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t004258001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004258001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004259001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t004259001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t004259001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t004259001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004259001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t004259001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004259001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004261001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	InterPro
NV2t004261001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t004261001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t004261001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004265001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004265001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t004265001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t004267001.1	biological_process	GO:0070370	cellular heat acclimation	"Any process that increases heat tolerance of a cell in response to high temperatures." [GOC:jp]	PANTHER
NV2t004267001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	InterPro
NV2t004267001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t004268001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004268001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004268001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004268001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004270001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004270001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t004270001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t004272001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004272001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004272001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004272001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004272001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t004274001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004274001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004274001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004274001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004275001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t004275001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t004275001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004275002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t004275002.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t004275002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004275003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t004275003.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t004275003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004276001.1	biological_process	GO:0001522	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule." [GOC:hjd, GOC:mah]	OMA
NV2t004276001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t004276001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t004276001.1	biological_process	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	"Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]	PANTHER
NV2t004276001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t004278001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004278002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004278003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004279001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t004280001.1	biological_process	GO:0016480	negative regulation of transcription by RNA polymerase III	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators]	InterPro
NV2t004280001.1	biological_process	GO:0016480	negative regulation of transcription by RNA polymerase III	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators]	OMA
NV2t004283001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004283001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t004283001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004283001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004284001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t004284001.1	biological_process	GO:0006998	nuclear envelope organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]	OMA
NV2t004284001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t004284001.1	biological_process	GO:0051292	nuclear pore complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah]	OMA
NV2t004284001.1	biological_process	GO:0060391	positive regulation of SMAD protein signal transduction	"Any process that increases the rate, frequency or extent of SMAD protein signal transduction." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t004284001.1	biological_process	GO:0060395	SMAD protein signal transduction	"An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF]	OMA
NV2t004284001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t004284001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t004284001.1	cellular_component	GO:0034399	nuclear periphery	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]	OMA
NV2t004284001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004284001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t004284001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t004284001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t004284002.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t004284002.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t004284003.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t004284003.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t004286001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004287001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t004287001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004287001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004287001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t004287001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t004293001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004295001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t004295001.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t004295001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004295001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t004295001.1	molecular_function	GO:0043023	ribosomal large subunit binding	"Binding to a large ribosomal subunit." [GOC:go_curators]	PANTHER
NV2t004299001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004299001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t004299001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t004299001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004299001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t004299001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004299001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004299001.1	cellular_component	GO:0005956	protein kinase CK2 complex	"A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779]	OMA
NV2t004299001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t004299001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004299001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004299002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004299002.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t004299002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004299003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004299003.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t004299003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004299004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004299004.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t004299004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004301001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t004301001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t004303001.1	biological_process	GO:0097035	regulation of membrane lipid distribution	"Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909]	PANTHER
NV2t004303001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004305001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	InterPro
NV2t004305001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t004305001.1	cellular_component	GO:1990221	L-cysteine desulfurase complex	"A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer." [GOC:bhm, PMID:11827487]	PANTHER
NV2t004306001.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	InterPro
NV2t004306002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004306002.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	InterPro
NV2t004306003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004306003.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	InterPro
NV2t004307001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004307001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004310002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t004310003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t004311001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004311001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004311002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004312001.1	biological_process	GO:0006858	extracellular transport	"The transport of substances that occurs outside cells." [GOC:go_curators]	OMA
NV2t004312001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t004312001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t004312001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t004312001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t004312001.1	biological_process	GO:0043393	regulation of protein binding	"Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators]	OMA
NV2t004312001.1	biological_process	GO:0045880	positive regulation of smoothened signaling pathway	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t004312001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t004312001.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	InterPro
NV2t004312001.1	biological_process	GO:0099111	microtubule-based transport	"A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t004312001.1	biological_process	GO:1903829	positive regulation of protein localization	"Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t004312001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t004312001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t004312001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t004312001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t004312001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t004312001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t004312001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t004313001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t004313001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t004313001.1	molecular_function	GO:0034338	short-chain carboxylesterase activity	"Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp]	OMA
NV2t004314001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004314001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t004315001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004315001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t004316001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004317001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t004317002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004317002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004317002.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t004317002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t004317002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t004318001.1	cellular_component	GO:0016528	sarcoplasm	"The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t004318001.1	cellular_component	GO:0030314	junctional membrane complex	"Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622]	InterPro
NV2t004318001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t004318002.1	cellular_component	GO:0030314	junctional membrane complex	"Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622]	InterPro
NV2t004319001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004319001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004319001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t004319001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t004319001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t004319001.1	molecular_function	GO:0042171	lysophosphatidic acid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]	PANTHER
NV2t004320001.1	biological_process	GO:0000096	sulfur amino acid metabolic process	"The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]	OMA
NV2t004320001.1	biological_process	GO:0009069	serine family amino acid metabolic process	"The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t004320001.1	molecular_function	GO:0016846	carbon-sulfur lyase activity	"Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]	OMA
NV2t004320001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004320001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t004321001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t004321001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t004321001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t004321001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t004322001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t004322001.1	biological_process	GO:0034394	protein localization to cell surface	"A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]	OMA
NV2t004322001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t004322001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	OMA
NV2t004322001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t004322002.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t004324001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004324001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004324001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t004327001.1	biological_process	GO:0097745	mitochondrial tRNA 5'-end processing	"The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:pf, PMID:21307182, PMID:26143376, PMID:27484477]	PANTHER
NV2t004327001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004329001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t004329001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t004329001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t004329001.1	biological_process	GO:0010977	negative regulation of neuron projection development	"Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t004329001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t004329001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t004329001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t004329001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	OMA
NV2t004329001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t004329002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t004329002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t004329002.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t004329003.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t004329003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t004330001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t004330001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t004330001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004330001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t004330001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t004330001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t004330001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t004330001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004331001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t004331001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t004331001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t004331001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t004331001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t004332001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t004332001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t004332001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t004332001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t004332001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t004332001.1	biological_process	GO:0034969	obsolete histone arginine methylation	"OBSOLETE. The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah]	PANTHER
NV2t004332001.1	biological_process	GO:0035246	peptidyl-arginine N-methylation	"The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein." [GOC:bf]	InterPro
NV2t004332001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t004332001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t004332001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t004332001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004332001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004332001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t004332001.1	molecular_function	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	OMA
NV2t004332001.1	molecular_function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069]	OMA
NV2t004332001.1	molecular_function	GO:0044020	histone H4R3 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me." [GOC:mah, PMID:17898714]	OMA
NV2t004335001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	InterPro
NV2t004335001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	OMA
NV2t004335001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	PANTHER
NV2t004335001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t004335001.1	molecular_function	GO:0019781	NEDD8 activating enzyme activity	"Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924]	OMA
NV2t004336001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t004336001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t004336001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t004339001.1	biological_process	GO:0002183	cytoplasmic translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]	OMA
NV2t004339001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t004339001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t004339001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004339001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t004339001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t004339001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t004339001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t004339001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	PANTHER
NV2t004340001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004341001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t004341002.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t004344001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	OMA
NV2t004344001.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	OMA
NV2t004344001.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	PANTHER
NV2t004344001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t004344001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004346001.1	biological_process	GO:0009065	glutamine family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t004346001.1	biological_process	GO:0009068	aspartate family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t004346001.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t004346001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004346001.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	InterPro
NV2t004346001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t004346001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004346001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t004346001.1	molecular_function	GO:0070003	threonine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t004346002.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t004346002.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	InterPro
NV2t004346002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004347001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t004347001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004349001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004349001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t004349001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004349001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004351001.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t004351001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004351002.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t004351002.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	InterPro
NV2t004351002.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t004351002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004351002.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t004351002.1	molecular_function	GO:0070003	threonine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t004351003.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t004351003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004351004.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t004351004.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	InterPro
NV2t004351004.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004351005.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t004351005.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	InterPro
NV2t004351005.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004351006.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t004351006.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	InterPro
NV2t004351006.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004352001.1	biological_process	GO:0006020	inositol metabolic process	"The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684]	OMA
NV2t004352001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t004352001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	InterPro
NV2t004352001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	OMA
NV2t004352001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	OMA
NV2t004352001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	PANTHER
NV2t004352001.1	molecular_function	GO:0008934	inositol monophosphate 1-phosphatase activity	"Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]	InterPro
NV2t004352001.1	molecular_function	GO:0052745	inositol phosphate phosphatase activity	"Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]	OMA
NV2t004352002.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	PANTHER
NV2t004352003.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	InterPro
NV2t004352003.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	PANTHER
NV2t004352003.1	molecular_function	GO:0008934	inositol monophosphate 1-phosphatase activity	"Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]	InterPro
NV2t004352004.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	PANTHER
NV2t004355001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004355001.1	molecular_function	GO:2001069	glycogen binding	"Binding to glycogen." [GOC:mengo_curators]	PANTHER
NV2t004356001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t004356001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004356002.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t004356002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004358001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t004358001.1	biological_process	GO:0016578	obsolete histone deubiquitination	"OBSOLETE. The modification of histones by removal of ubiquitin groups." [GOC:ai]	OMA
NV2t004358001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t004358001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004358001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t004358001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t004358001.1	cellular_component	GO:0070390	transcription export complex 2	"A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829]	OMA
NV2t004358001.1	cellular_component	GO:0071819	DUBm complex	"A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473]	OMA
NV2t004358001.1	cellular_component	GO:0071819	DUBm complex	"A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473]	PANTHER
NV2t004358001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t004358001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t004359002.1	biological_process	GO:0097250	mitochondrial respirasome assembly	"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]	InterPro
NV2t004359002.1	biological_process	GO:0097250	mitochondrial respirasome assembly	"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]	OMA
NV2t004359002.1	cellular_component	GO:0005746	mitochondrial respirasome	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]	OMA
NV2t004359003.1	biological_process	GO:0097250	mitochondrial respirasome assembly	"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]	InterPro
NV2t004360001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t004360001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t004360001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t004360001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t004360001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t004360001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t004361001.1	biological_process	GO:0018171	peptidyl-cysteine oxidation	"The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262]	PANTHER
NV2t004361001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t004361001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004361001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t004361001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t004361001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t004363001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t004363001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t004363002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t004366001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004366001.1	molecular_function	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	PANTHER
NV2t004367001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t004367001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t004367001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004367001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t004368001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004368001.1	molecular_function	GO:2001069	glycogen binding	"Binding to glycogen." [GOC:mengo_curators]	PANTHER
NV2t004370001.1	biological_process	GO:0005979	regulation of glycogen biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	OMA
NV2t004370001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004370001.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t004370001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004370001.1	molecular_function	GO:0008157	protein phosphatase 1 binding	"Binding to a protein phosphatase 1." [GOC:jl]	OMA
NV2t004370001.1	molecular_function	GO:2001069	glycogen binding	"Binding to glycogen." [GOC:mengo_curators]	OMA
NV2t004370001.1	molecular_function	GO:2001069	glycogen binding	"Binding to glycogen." [GOC:mengo_curators]	PANTHER
NV2t004371001.1	molecular_function	GO:0042302	structural constituent of cuticle	"The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]	OMA
NV2t004372001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t004372001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t004372001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t004372001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	OMA
NV2t004372001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	PANTHER
NV2t004372001.1	cellular_component	GO:0030870	Mre11 complex	"Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]	OMA
NV2t004372001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t004372001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004373001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t004373001.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t004373001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t004373001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t004373001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t004373001.1	biological_process	GO:0019400	alditol metabolic process	"The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]	OMA
NV2t004373001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	OMA
NV2t004373001.1	biological_process	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	OMA
NV2t004373001.1	biological_process	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t004373001.1	biological_process	GO:0034637	obsolete cellular carbohydrate biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah]	OMA
NV2t004373001.1	biological_process	GO:0042594	response to starvation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]	OMA
NV2t004373001.1	biological_process	GO:0046173	polyol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators]	OMA
NV2t004373001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t004373001.1	biological_process	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	OMA
NV2t004373001.1	biological_process	GO:0071333	cellular response to glucose stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]	OMA
NV2t004373001.1	biological_process	GO:0071333	cellular response to glucose stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]	PANTHER
NV2t004373001.1	biological_process	GO:0071383	cellular response to steroid hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah]	OMA
NV2t004373001.1	biological_process	GO:1901655	cellular response to ketone	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t004373001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004373001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004373001.1	molecular_function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	"Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32]	InterPro
NV2t004373001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004373001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t004373001.1	molecular_function	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	InterPro
NV2t004373001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t004375001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t004375001.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t004375001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t004375001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t004375001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t004375001.1	biological_process	GO:0019400	alditol metabolic process	"The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]	OMA
NV2t004375001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	OMA
NV2t004375001.1	biological_process	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	OMA
NV2t004375001.1	biological_process	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t004375001.1	biological_process	GO:0034637	obsolete cellular carbohydrate biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah]	OMA
NV2t004375001.1	biological_process	GO:0042594	response to starvation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]	OMA
NV2t004375001.1	biological_process	GO:0046173	polyol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators]	OMA
NV2t004375001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t004375001.1	biological_process	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	OMA
NV2t004375001.1	biological_process	GO:0071333	cellular response to glucose stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]	OMA
NV2t004375001.1	biological_process	GO:0071333	cellular response to glucose stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]	PANTHER
NV2t004375001.1	biological_process	GO:0071383	cellular response to steroid hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah]	OMA
NV2t004375001.1	biological_process	GO:1901655	cellular response to ketone	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t004375001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004375001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004375001.1	molecular_function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	"Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32]	InterPro
NV2t004375001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004375001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t004375001.1	molecular_function	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	InterPro
NV2t004375001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t004377001.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t004377001.1	biological_process	GO:0071333	cellular response to glucose stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]	PANTHER
NV2t004377001.1	molecular_function	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	InterPro
NV2t004381001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	InterPro
NV2t004381001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004382001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t004382001.1	biological_process	GO:0010634	positive regulation of epithelial cell migration	"Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t004382001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t004382001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t004382001.1	biological_process	GO:0044242	cellular lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t004382001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t004382001.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t004382001.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t004382001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004382001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004382001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004382001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t004382002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t004382002.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t004382002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004382002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004382002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t004383001.1	biological_process	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t004384001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t004384001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t004385001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004386001.1	biological_process	GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	"The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474]	PANTHER
NV2t004388001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004388001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t004388001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	OMA
NV2t004388001.1	biological_process	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004388001.1	biological_process	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	"An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component." [GOC:al, GOC:bf, PMID:16079177]	OMA
NV2t004388001.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t004388001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t004388001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004388001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004388001.1	molecular_function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655]	OMA
NV2t004388001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004389001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t004389001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t004389001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t004389001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004389001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004389001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t004389001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t004389001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t004389001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t004391001.1	biological_process	GO:0006268	DNA unwinding involved in DNA replication	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]	OMA
NV2t004391001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t004391001.1	biological_process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	"Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]	OMA
NV2t004391001.1	biological_process	GO:1902680	positive regulation of RNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie]	OMA
NV2t004391001.1	biological_process	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	OMA
NV2t004391001.1	biological_process	GO:1902975	mitotic DNA replication initiation	"Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]	PANTHER
NV2t004391001.1	cellular_component	GO:0000811	GINS complex	"A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]	OMA
NV2t004391001.1	cellular_component	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	OMA
NV2t004392001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t004392001.1	biological_process	GO:0009436	glyoxylate catabolic process	"The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]	OMA
NV2t004392001.1	biological_process	GO:0019481	L-alanine catabolic process, by transamination	"The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators]	PANTHER
NV2t004392001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t004392001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004392001.1	molecular_function	GO:0008453	alanine-glyoxylate transaminase activity	"Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44]	OMA
NV2t004392001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004392001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t004393001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t004393001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004393001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t004393001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t004395001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t004395001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t004395001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004395001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t004395001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t004395001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t004395001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t004396001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t004397001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004397001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004397001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004399001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t004399001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004403001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004403001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004403001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004405001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004405001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004405001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t004405001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004406001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t004406001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t004406001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	PANTHER
NV2t004406002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t004406002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t004406002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t004406002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	PANTHER
NV2t004406002.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t004410001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t004410001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t004410001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t004411001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t004411001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t004411001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t004412001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t004412001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t004412001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t004415001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004417001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004421001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004425001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t004425001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t004425001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t004425001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004425001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004425001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t004427001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t004427001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t004427001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t004427001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004427001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004427001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t004429001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t004429001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004431001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t004431001.1	biological_process	GO:0045332	phospholipid translocation	"The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]	OMA
NV2t004431001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t004431001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t004431001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t004431001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004431001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t004431001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t004431001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004431001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004431001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t004431001.1	molecular_function	GO:0140303	intramembrane lipid transporter activity	"Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084]	OMA
NV2t004431001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	InterPro
NV2t004431001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t004432001.1	biological_process	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t004432001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004432001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004432001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t004432002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004432002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t004435001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t004435002.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t004435003.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t004435004.1	biological_process	GO:0016482	cytosolic transport	"The directed movement of substances or organelles within the cytosol." [GOC:ai]	OMA
NV2t004435004.1	biological_process	GO:0034067	protein localization to Golgi apparatus	"A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]	OMA
NV2t004435004.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	OMA
NV2t004435004.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t004435004.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	InterPro
NV2t004435004.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t004435004.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t004436001.1	biological_process	GO:0000731	DNA synthesis involved in DNA repair	"Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855]	OMA
NV2t004436001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t004436001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t004436001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t004436001.1	biological_process	GO:0006282	regulation of DNA repair	"Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]	OMA
NV2t004436001.1	biological_process	GO:0030174	regulation of DNA-templated DNA replication initiation	"Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah]	OMA
NV2t004436001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t004436001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004436001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t004436001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t004436001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004436001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t004436001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004436001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t004436001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t004436001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	PANTHER
NV2t004436001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t004440001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	PANTHER
NV2t004440003.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	PANTHER
NV2t004441001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t004441001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t004441001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t004441001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t004441001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t004441001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	InterPro
NV2t004441001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t004442001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t004442001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t004442001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t004443001.1	biological_process	GO:0006572	tyrosine catabolic process	"The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]	PANTHER
NV2t004443001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004443002.1	biological_process	GO:0006572	tyrosine catabolic process	"The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]	PANTHER
NV2t004443002.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t004443002.1	biological_process	GO:0009074	aromatic amino acid family catabolic process	"The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	OMA
NV2t004443002.1	molecular_function	GO:0004838	L-tyrosine:2-oxoglutarate aminotransferase activity	"Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5]	OMA
NV2t004443002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004443002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t004447001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t004447001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004448001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t004448001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t004448001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004449001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004449001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t004449001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004451001.1	biological_process	GO:0006370	7-methylguanosine mRNA capping	"The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:mah, PMID:9266685]	OMA
NV2t004451001.1	biological_process	GO:0006370	7-methylguanosine mRNA capping	"The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:mah, PMID:9266685]	PANTHER
NV2t004451001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t004451001.1	molecular_function	GO:0008174	mRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah]	OMA
NV2t004452001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t004452001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004452001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t004452001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t004452001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t004452001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t004452001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t004453001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t004453001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004453001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t004453001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t004453001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t004453001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t004453001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t004454001.1	biological_process	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	"Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]	OMA
NV2t004454001.1	biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]	OMA
NV2t004454001.1	biological_process	GO:0051457	maintenance of protein location in nucleus	"Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai]	OMA
NV2t004454001.1	biological_process	GO:0051457	maintenance of protein location in nucleus	"Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai]	PANTHER
NV2t004454001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t004455001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004456001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	InterPro
NV2t004456001.1	biological_process	GO:0006163	purine nucleotide metabolic process	"The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t004456001.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t004456001.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t004456001.1	biological_process	GO:0046130	purine ribonucleoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]	OMA
NV2t004456001.1	biological_process	GO:0072522	purine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t004456001.1	biological_process	GO:0072524	pyridine-containing compound metabolic process	"The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	OMA
NV2t004456001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004456001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t004458001.1	biological_process	GO:0015786	UDP-glucose transmembrane transport	"The process in which UDP-glucose is transported across a membrane." [GOC:ai]	OMA
NV2t004458001.1	biological_process	GO:0015786	UDP-glucose transmembrane transport	"The process in which UDP-glucose is transported across a membrane." [GOC:ai]	PANTHER
NV2t004458001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t004458001.1	cellular_component	GO:0005801	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	OMA
NV2t004458001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t004459001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t004459001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004459002.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t004459002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004459003.1	biological_process	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	PANTHER
NV2t004460002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t004461001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004461001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004461002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004461002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004461004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004461004.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004461005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004461005.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004461006.1	biological_process	GO:0032329	serine transport	"The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t004461006.1	biological_process	GO:0042940	D-amino acid transport	"The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]	OMA
NV2t004461006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004461006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004461006.1	molecular_function	GO:0015175	neutral L-amino acid transmembrane transporter activity	"Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004461006.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004461006.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004461007.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004461007.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004461008.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004461008.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004462001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t004462001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t004462001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t004462001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t004462001.1	biological_process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	"A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]	OMA
NV2t004462001.1	biological_process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	"A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]	PANTHER
NV2t004462001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004462001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004462001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t004462001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t004462001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t004462002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t004462002.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	PANTHER
NV2t004462002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t004463001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004463001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004463001.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	PANTHER
NV2t004463001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004463001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004463001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t004463001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004463001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004463001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004463001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t004468001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	PANTHER
NV2t004468001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t004468001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004468001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t004468001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t004468001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t004468001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t004468001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t004469001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t004469001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004469001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t004469001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t004469001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t004472001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	PANTHER
NV2t004474001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004475001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t004475001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t004477001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t004477001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t004477001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t004477001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004477001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004477002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t004478001.1	molecular_function	GO:0004089	carbonate dehydratase activity	"Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O." [EC:4.2.1.1]	OMA
NV2t004478001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004478001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004479001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t004479001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t004479001.1	biological_process	GO:0097494	regulation of vesicle size	"Any process that modulates the size of a vesicle." [GOC:pm, PMID:20007772]	OMA
NV2t004479001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t004479001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t004479001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004479001.1	cellular_component	GO:0045335	phagocytic vesicle	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t004479001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004479001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004479001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004480001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t004480001.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t004480001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t004480001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t004480001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004480001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t004480001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t004480001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t004480001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	OMA
NV2t004480001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t004481001.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	PANTHER
NV2t004481001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t004481001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t004481001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t004481001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t004481001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t004481001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t004481002.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	PANTHER
NV2t004481002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t004481002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t004482001.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	PANTHER
NV2t004482001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t004482001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t004482001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t004482001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t004482001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t004482001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t004482002.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	PANTHER
NV2t004482002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t004482002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t004482003.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	PANTHER
NV2t004482003.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t004482003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t004484001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004484001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t004484001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004485001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t004485001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t004485001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t004485003.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t004485003.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t004486001.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t004486001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004486002.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t004486002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004487001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004487001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t004487001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004487001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004490001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t004490002.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t004491001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t004491001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004491002.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t004491002.1	biological_process	GO:0006349	obsolete regulation of gene expression by genomic imprinting	"OBSOLETE. An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles." [PMID:11498578, PMID:31896690, PMID:7502071]	OMA
NV2t004491002.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t004491002.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t004491002.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t004491002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004491002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004491002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004491002.1	molecular_function	GO:0035241	protein-arginine omega-N monomethyltransferase activity	"Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine." [EC:2.1.1.321, PMID:14705965, RESID:AA0069]	OMA
NV2t004491002.1	molecular_function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069]	OMA
NV2t004491002.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t004491002.1	molecular_function	GO:0044020	histone H4R3 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me." [GOC:mah, PMID:17898714]	OMA
NV2t004491003.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t004491003.1	molecular_function	GO:0035241	protein-arginine omega-N monomethyltransferase activity	"Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine." [EC:2.1.1.321, PMID:14705965, RESID:AA0069]	PANTHER
NV2t004491004.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t004491004.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004492001.1	biological_process	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544]	OMA
NV2t004492001.1	biological_process	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544]	PANTHER
NV2t004492001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t004492001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004494001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004494001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004494001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004496001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t004496001.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t004501001.1	biological_process	GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]	OMA
NV2t004501001.1	biological_process	GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t004501001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004501001.1	molecular_function	GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	"Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]	OMA
NV2t004501001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t004502001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t004502002.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t004502003.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t004502004.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t004503001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t004503001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t004503001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	InterPro
NV2t004503001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t004503001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t004503002.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	InterPro
NV2t004504001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004506001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t004506001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t004506001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t004506001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t004506001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t004506001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t004507001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004507002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004507004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004508001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t004511001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t004511001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t004514001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t004514001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t004514001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t004514001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t004514001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t004514001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t004515001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004515001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004516001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t004516001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t004516001.1	molecular_function	GO:0004602	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]	OMA
NV2t004518001.1	biological_process	GO:0006661	phosphatidylinositol biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]	OMA
NV2t004518001.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t004518001.1	cellular_component	GO:0005774	vacuolar membrane	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]	OMA
NV2t004518001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t004518001.1	cellular_component	GO:0035032	phosphatidylinositol 3-kinase complex, class III	"A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069]	OMA
NV2t004518001.1	cellular_component	GO:0070772	PAS complex	"A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p." [PMID:18950639, PMID:19037259, PMID:19158662]	PANTHER
NV2t004518001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t004519001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004521001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004521001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004521001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004522001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t004522001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t004522001.1	biological_process	GO:0045165	cell fate commitment	"The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate." [ISBN:0716731185]	OMA
NV2t004522001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t004522001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t004522001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t004522001.1	molecular_function	GO:0005109	frizzled binding	"Binding to a frizzled (fz) receptor." [GOC:ceb]	OMA
NV2t004522001.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t004523001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004526001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t004526001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t004526001.1	cellular_component	GO:0045272	plasma membrane respiratory chain complex I	"A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t004526001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t004526001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t004526001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004526001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t004527001.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	PANTHER
NV2t004527002.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	PANTHER
NV2t004528002.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t004528002.1	biological_process	GO:0051347	positive regulation of transferase activity	"Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]	OMA
NV2t004528002.1	biological_process	GO:0051973	positive regulation of telomerase activity	"Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai]	InterPro
NV2t004528002.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	OMA
NV2t004528002.1	biological_process	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	OMA
NV2t004528002.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t004528002.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t004528002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t004528002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t004528002.1	molecular_function	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	OMA
NV2t004528003.1	biological_process	GO:0051973	positive regulation of telomerase activity	"Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai]	InterPro
NV2t004529001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t004529001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t004529001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004529001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004529001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t004529001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t004529001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004529001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004530001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t004530001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004530001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004531001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t004531001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004531002.1	biological_process	GO:0048167	regulation of synaptic plasticity	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]	OMA
NV2t004531002.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t004531002.1	biological_process	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	"Any process that regulates the concentration of calcium in the presynaptic cytosol." [GOC:dos]	OMA
NV2t004531002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004531002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004531002.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t004531002.1	cellular_component	GO:0043195	terminal bouton	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]	OMA
NV2t004531002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004531002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004531003.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t004531003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004532001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t004532001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t004532001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004532001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004532001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t004532001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t004532001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004532001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004532002.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t004532002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004532003.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	PANTHER
NV2t004532003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004533001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004533001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004533001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004533002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004533002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004533003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004533003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004533004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004533004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004535001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004537001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t004537001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004537001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004538001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t004538001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t004538001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	OMA
NV2t004538001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004538001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t004538001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004538001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t004538001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t004538001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t004538001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t004538001.1	molecular_function	GO:0004523	RNA-DNA hybrid ribonuclease activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	OMA
NV2t004538001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004538001.1	molecular_function	GO:0008409	5'-3' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai]	OMA
NV2t004538001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t004538001.1	molecular_function	GO:0017108	5'-flap endonuclease activity	"Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]	OMA
NV2t004538001.1	molecular_function	GO:0030145	manganese ion binding	"Binding to a manganese ion (Mn)." [GOC:ai]	PANTHER
NV2t004538001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t004539001.1	biological_process	GO:0006084	acetyl-CoA metabolic process	"The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]	OMA
NV2t004539001.1	biological_process	GO:0006554	lysine catabolic process	"The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]	OMA
NV2t004539001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t004539001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004539001.1	molecular_function	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t004539001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t004539001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t004541001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t004541001.1	biological_process	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	OMA
NV2t004541001.1	biological_process	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	OMA
NV2t004541001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	OMA
NV2t004541001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	PANTHER
NV2t004541001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t004541001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t004541001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004541001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004541001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004541001.1	molecular_function	GO:0031386	protein tag activity	"A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]	OMA
NV2t004541001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t004542001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t004542001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	InterPro
NV2t004542002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t004542002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	InterPro
NV2t004542002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004542003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t004542003.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	InterPro
NV2t004544001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004544001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t004544001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004544002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t004548001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t004548001.1	biological_process	GO:0034477	U6 snRNA 3'-end processing	"Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah]	InterPro
NV2t004548001.1	biological_process	GO:0034477	U6 snRNA 3'-end processing	"Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah]	PANTHER
NV2t004548001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004548001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t004550001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t004550001.1	biological_process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]	OMA
NV2t004550001.1	biological_process	GO:0006382	adenosine to inosine editing	"The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837]	OMA
NV2t004550001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	OMA
NV2t004550001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t004550001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t004550001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t004550001.1	biological_process	GO:0010001	glial cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]	OMA
NV2t004550001.1	biological_process	GO:0019827	stem cell population maintenance	"The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]	OMA
NV2t004550001.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	OMA
NV2t004550001.1	biological_process	GO:0034644	cellular response to UV	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]	OMA
NV2t004550001.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t004550001.1	biological_process	GO:0045948	positive regulation of translational initiation	"Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t004550001.1	biological_process	GO:0048477	oogenesis	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]	OMA
NV2t004550001.1	biological_process	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	OMA
NV2t004550001.1	biological_process	GO:0051445	regulation of meiotic cell cycle	"Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004550001.1	biological_process	GO:0061157	mRNA destabilization	"Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh]	OMA
NV2t004550001.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t004550001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t004550001.1	biological_process	GO:2000765	regulation of cytoplasmic translation	"Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	OMA
NV2t004550001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t004550001.1	cellular_component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	"A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B)." [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715, PMID:24407421, PMID:29507755, PMID:29535189, PMID:29547716]	OMA
NV2t004550001.1	molecular_function	GO:0001734	mRNA m(6)A methyltransferase activity	"Catalysis of the reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H+ + S-adenosyl-L-homocysteine. This activity is the methylation of adenines in mRNA with the consensus sequence RRACH, where R is a purine, and H is C, A, or U." [EC:2.1.1.348, GOC:hjd]	OMA
NV2t004550001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t004550001.1	molecular_function	GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62]	InterPro
NV2t004550001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t004550001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t004550001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t004550002.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t004551001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004552001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t004552001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t004552001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t004552001.1	biological_process	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t004552001.1	biological_process	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	OMA
NV2t004552001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t004552001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t004552001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	OMA
NV2t004552001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t004553001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t004553002.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t004553003.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t004553003.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t004553003.1	molecular_function	GO:0004089	carbonate dehydratase activity	"Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O." [EC:4.2.1.1]	OMA
NV2t004553003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004553003.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t004553004.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t004557001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004557001.1	biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t004557001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t004557001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t004558001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004558001.1	biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t004558001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t004558001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t004560001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t004560001.1	biological_process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	"A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle]	OMA
NV2t004560001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t004560001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004560001.1	molecular_function	GO:0030332	cyclin binding	"Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]	OMA
NV2t004561001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	PANTHER
NV2t004562001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004562001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004562001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t004562001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	PANTHER
NV2t004563001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t004563001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t004563001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t004563002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t004563002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t004563002.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t004563002.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t004563002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004563002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t004563002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t004563003.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t004563003.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t004563003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t004564001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t004564001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004564001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004564001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004564001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t004564001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004564001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t004565001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t004565001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004566001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004568001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004568001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004570001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t004570001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t004570001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t004570001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004570001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004570001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t004571001.1	biological_process	GO:0001676	long-chain fatty acid metabolic process	"The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ajp]	OMA
NV2t004571001.1	biological_process	GO:0006690	icosanoid metabolic process	"The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma]	OMA
NV2t004571001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t004571001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t004571001.1	biological_process	GO:0009650	UV protection	"Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]	OMA
NV2t004571001.1	biological_process	GO:0010823	obsolete negative regulation of mitochondrion organization	"OBSOLETE. Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	OMA
NV2t004571001.1	biological_process	GO:0033559	unsaturated fatty acid metabolic process	"The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah]	OMA
NV2t004571001.1	biological_process	GO:0040029	epigenetic regulation of gene expression	"A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]	OMA
NV2t004571001.1	biological_process	GO:0042542	response to hydrogen peroxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]	OMA
NV2t004571001.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	OMA
NV2t004571001.1	biological_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t004571001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004571001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t004571001.1	biological_process	GO:0050678	regulation of epithelial cell proliferation	"Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]	OMA
NV2t004571001.1	biological_process	GO:0060047	heart contraction	"The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]	OMA
NV2t004571001.1	biological_process	GO:0061136	regulation of proteasomal protein catabolic process	"Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]	OMA
NV2t004571001.1	biological_process	GO:0120254	olefinic compound metabolic process	"The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc]	OMA
NV2t004571001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t004571001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004571001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004571001.1	cellular_component	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	OMA
NV2t004571001.1	molecular_function	GO:0004602	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]	OMA
NV2t004571001.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	OMA
NV2t004573001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	PANTHER
NV2t004574001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	PANTHER
NV2t004575001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t004575001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t004575001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	InterPro
NV2t004575001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	OMA
NV2t004575001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t004575001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t004575001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t004575001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t004575001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t004575001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t004575001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t004576001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t004576001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t004576001.1	biological_process	GO:0007040	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	OMA
NV2t004576001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t004576001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	OMA
NV2t004576001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004576001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004576001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t004576001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t004577001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004577001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004577001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004577002.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004578001.1	biological_process	GO:0031106	septin ring organization	"Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah]	PANTHER
NV2t004583001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004583001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t004584001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004584001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t004586001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	InterPro
NV2t004587001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	InterPro
NV2t004587001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	OMA
NV2t004587001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t004588001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004589001.1	cellular_component	GO:1990072	TRAPPIII protein complex	"A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257]	PANTHER
NV2t004589002.1	cellular_component	GO:1990072	TRAPPIII protein complex	"A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257]	PANTHER
NV2t004589002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004590001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t004590001.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t004590001.1	molecular_function	GO:0005246	calcium channel regulator activity	"Modulates the activity of a calcium channel." [GOC:mah]	OMA
NV2t004590001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004590001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004590001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t004591001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	InterPro
NV2t004591001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t004591001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	PANTHER
NV2t004591001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t004592001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	InterPro
NV2t004592001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	OMA
NV2t004592001.1	biological_process	GO:0050890	cognition	"The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908]	OMA
NV2t004592002.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	InterPro
NV2t004598001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t004600001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t004603002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004603003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004603004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004603005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004603006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004603007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004622001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t004622001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t004622001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004622001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t004625001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t004625001.1	biological_process	GO:0038127	ERBB signaling pathway	"The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Wikipedia:ErbB]	OMA
NV2t004625001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t004625001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t004625001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t004625001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	OMA
NV2t004625001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t004625001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t004625001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004625001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004625001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004625001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t004625001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t004625001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t004625001.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	OMA
NV2t004625001.1	molecular_function	GO:0048306	calcium-dependent protein binding	"Binding to a protein or protein complex in the presence of calcium." [GOC:jid, PMID:10485905]	OMA
NV2t004626001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t004626001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t004626001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t004626001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t004629001.1	biological_process	GO:0106035	protein maturation by [4Fe-4S] cluster transfer	"The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]	PANTHER
NV2t004630001.1	biological_process	GO:0015833	peptide transport	"The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t004630001.1	biological_process	GO:0090374	oligopeptide export from mitochondrion	"The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115]	PANTHER
NV2t004630001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t004630001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004630001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004630001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004630001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t004630001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t004630001.1	molecular_function	GO:1904680	peptide transmembrane transporter activity	"Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw]	OMA
NV2t004631001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t004631001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t004631001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t004631001.1	biological_process	GO:0007041	lysosomal transport	"The directed movement of substances into, out of or within a lysosome." [GOC:ai]	OMA
NV2t004631001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t004631001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t004631001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t004631001.1	biological_process	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t004631001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t004631001.1	biological_process	GO:0032387	negative regulation of intracellular transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t004631001.1	biological_process	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	OMA
NV2t004631001.1	biological_process	GO:0035418	protein localization to synapse	"Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]	OMA
NV2t004631001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t004631001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t004631001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t004631001.1	biological_process	GO:0045056	transcytosis	"The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363]	OMA
NV2t004631001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t004631001.1	biological_process	GO:0050728	negative regulation of inflammatory response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]	OMA
NV2t004631001.1	biological_process	GO:0051963	regulation of synapse assembly	"Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	OMA
NV2t004631001.1	biological_process	GO:0060159	regulation of dopamine receptor signaling pathway	"Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]	OMA
NV2t004631001.1	biological_process	GO:0061357	positive regulation of Wnt protein secretion	"Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472]	OMA
NV2t004631001.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t004631001.1	biological_process	GO:0099003	vesicle-mediated transport in synapse	"Any vesicle-mediated transport that occurs in a synapse." [GOC:dos]	OMA
NV2t004631001.1	biological_process	GO:0099175	regulation of postsynapse organization	"Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004631001.1	biological_process	GO:0099638	endosome to plasma membrane protein transport	"The directed movement of proteins from the endosome to the plasma membrane in transport vesicles." [GOC:dos]	OMA
NV2t004631001.1	biological_process	GO:0120035	regulation of plasma membrane bounded cell projection organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc]	OMA
NV2t004631001.1	biological_process	GO:1901215	obsolete negative regulation of neuron death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t004631001.1	biological_process	GO:2000331	regulation of terminal button organization	"Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]	OMA
NV2t004631001.1	cellular_component	GO:0000323	lytic vacuole	"A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]	OMA
NV2t004631001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004631001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t004631001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t004631001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004631001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t004631001.1	cellular_component	GO:0030904	retromer complex	"A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157]	OMA
NV2t004631001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t004631001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t004631001.1	cellular_component	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	OMA
NV2t004631001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t004632001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t004632001.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t004632002.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t004632002.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t004633001.1	biological_process	GO:0033499	galactose catabolic process via UDP-galactose	"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821]	PANTHER
NV2t004636001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t004636002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t004636003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t004636004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t004636004.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t004636004.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t004636004.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t004636005.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t004636006.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t004639001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t004639001.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	OMA
NV2t004639001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t004639001.1	cellular_component	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	OMA
NV2t004639001.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	InterPro
NV2t004639001.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	PANTHER
NV2t004639001.1	cellular_component	GO:1990498	mitotic spindle microtubule	"Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw]	OMA
NV2t004639001.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	OMA
NV2t004640001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004640001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004640001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t004642001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004642001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004642001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t004645001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004645001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004645001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t004646001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004646002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004646003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004647001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004647001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t004649001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004649001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t004649002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004649002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t004649003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004650001.1	biological_process	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	InterPro
NV2t004650001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t004650001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004650001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004650001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t004650001.1	molecular_function	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	OMA
NV2t004654001.1	cellular_component	GO:0009941	chloroplast envelope	"The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]	PANTHER
NV2t004654002.1	cellular_component	GO:0009941	chloroplast envelope	"The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]	PANTHER
NV2t004655001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t004655001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004658001.1	cellular_component	GO:0009941	chloroplast envelope	"The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]	PANTHER
NV2t004658002.1	cellular_component	GO:0009941	chloroplast envelope	"The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]	PANTHER
NV2t004658003.1	cellular_component	GO:0009941	chloroplast envelope	"The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]	PANTHER
NV2t004660001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t004660001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t004660001.1	biological_process	GO:0061014	positive regulation of mRNA catabolic process	"Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t004660001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004660001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004660001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004660001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t004660001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004660001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t004666001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004666001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004666001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004666001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004666002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004666002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004670001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004670001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t004670002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004670003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004670004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004673001.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t004673001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004673001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004673001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004673001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t004673001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004673002.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t004673002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004673002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004673002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004674001.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t004674001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t004674001.1	molecular_function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+." [EC:2.7.1.154, RHEA:18373]	OMA
NV2t004674001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t004674001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t004674001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	PANTHER
NV2t004674002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t004674002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t004674002.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	PANTHER
NV2t004675001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t004675001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t004675001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004675001.1	molecular_function	GO:0000987	cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018]	OMA
NV2t004675001.1	molecular_function	GO:0106140	P-TEFb complex binding	"Binding to a P-TEFb complex." [GOC:pga, PMID:18391197]	PANTHER
NV2t004676001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t004676001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t004676001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004676001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004676001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004676001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t004678001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t004678001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t004678001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t004678001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t004678001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t004678001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t004678001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t004678001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t004679001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t004679001.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t004680001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t004680001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t004680001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t004680001.1	biological_process	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	OMA
NV2t004680001.1	biological_process	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	OMA
NV2t004680001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t004680001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t004680001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004680001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t004680001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t004681001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t004681001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t004681001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t004681001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t004684001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t004684001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004684001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004684001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004685001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t004685001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t004685001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t004685001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t004685001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t004685001.1	biological_process	GO:0006430	lysyl-tRNA aminoacylation	"The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t004685001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t004685001.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t004685001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t004685001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t004685001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t004685001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004685001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004685001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004685001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t004685001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	PANTHER
NV2t004685001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t004685001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t004685001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004685001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t004685001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004685001.1	molecular_function	GO:0070566	adenylyltransferase activity	"Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]	OMA
NV2t004686001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004686001.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t004686002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t004686002.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t004686002.1	biological_process	GO:0035066	obsolete positive regulation of histone acetylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]	OMA
NV2t004686002.1	biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t004686002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004686002.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t004686002.1	molecular_function	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	OMA
NV2t004686002.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t004686002.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t004686002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004686002.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	OMA
NV2t004686002.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t004686003.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t004690001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t004692001.1	biological_process	GO:0046599	regulation of centriole replication	"Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]	OMA
NV2t004692001.1	biological_process	GO:0046599	regulation of centriole replication	"Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]	PANTHER
NV2t004692001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t004693001.1	biological_process	GO:0051598	meiotic recombination checkpoint signaling	"A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes." [PMID:14718568]	PANTHER
NV2t004693001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004693001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004694001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004694001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t004709001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t004709001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t004709001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t004710001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t004710001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004714001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t004714001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t004714001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t004714001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t004714001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004714001.1	biological_process	GO:1901796	regulation of signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	OMA
NV2t004714001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t004714001.1	cellular_component	GO:0070545	PeBoW complex	"A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269]	PANTHER
NV2t004714001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t004714001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t004714001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004714001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004714001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t004714002.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t004714002.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t004714002.1	cellular_component	GO:0070545	PeBoW complex	"A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269]	PANTHER
NV2t004714002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004715001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t004715001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	InterPro
NV2t004715001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t004715001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	InterPro
NV2t004715001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004715001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004715001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004720001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004720002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004723001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004724001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t004724001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004724002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004726001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004727001.1	biological_process	GO:0090158	endoplasmic reticulum membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t004727001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	InterPro
NV2t004727001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004734001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t004734001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t004734001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004734001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004734001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t004735001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t004735001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t004735001.1	cellular_component	GO:0034455	t-UTP complex	"A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p." [GOC:krc, GOC:mah, GOC:vw, PMID:17515605]	PANTHER
NV2t004735001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t004735001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004736001.1	biological_process	GO:0008544	epidermis development	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]	OMA
NV2t004736001.1	biological_process	GO:0010793	regulation of mRNA export from nucleus	"Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t004736001.1	biological_process	GO:0022404	molting cycle process	"A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete]	OMA
NV2t004736001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	PANTHER
NV2t004736001.1	biological_process	GO:0036416	tRNA stabilization	"Prevention of degradation of tRNA molecules." [GOC:aa, GOC:bf, PMID:20459084]	OMA
NV2t004736001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t004736001.1	biological_process	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	OMA
NV2t004736001.1	biological_process	GO:0071695	anatomical structure maturation	"A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]	OMA
NV2t004736001.1	biological_process	GO:2000736	regulation of stem cell differentiation	"Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol]	OMA
NV2t004736001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t004736001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004736001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t004736001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t004736001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004736001.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	InterPro
NV2t004736001.1	molecular_function	GO:0008174	mRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah]	OMA
NV2t004736001.1	molecular_function	GO:0016427	tRNA (cytidine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [GOC:go-curators]	OMA
NV2t004736001.1	molecular_function	GO:0016428	tRNA (cytidine-5-)-methyltransferase activity	"Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49)." [RHEA:61468]	InterPro
NV2t004738001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t004738001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t004739001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t004740001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t004740001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t004740001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t004740001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t004740001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t004743001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004744001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t004744001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004744001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004745001.1	biological_process	GO:1903566	positive regulation of protein localization to cilium	"Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]	PANTHER
NV2t004745002.1	biological_process	GO:1903566	positive regulation of protein localization to cilium	"Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]	PANTHER
NV2t004745003.1	biological_process	GO:1903566	positive regulation of protein localization to cilium	"Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]	PANTHER
NV2t004746001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t004746001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t004746001.1	cellular_component	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	OMA
NV2t004746001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t004746001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t004746001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t004749001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t004749001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004749001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	InterPro
NV2t004749001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t004749001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t004749001.1	molecular_function	GO:0017150	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H." [PMID:11983710, PMID:22123979]	PANTHER
NV2t004749001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t004749001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t004752001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004752001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004752001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004752001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t004753001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t004755001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t004755002.1	biological_process	GO:0006066	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732]	OMA
NV2t004755002.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t004755002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t004755002.1	biological_process	GO:0006720	isoprenoid metabolic process	"The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684]	OMA
NV2t004755002.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t004755002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004755002.1	cellular_component	GO:0031501	mannosyltransferase complex	"A complex that posseses mannosyltransferase activity." [GOC:mah]	OMA
NV2t004755002.1	molecular_function	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	"Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]	OMA
NV2t004755002.1	molecular_function	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	"Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83]	InterPro
NV2t004755002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t004755003.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t004755003.1	molecular_function	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity	"Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83]	InterPro
NV2t004756001.1	biological_process	GO:0009117	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	OMA
NV2t004756001.1	cellular_component	GO:1902560	GMP reductase complex	"An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H+ + NADPH => IMP + NADP+ + NH4." [GOC:bhm, GOC:TermGenie, PMID:12009299]	InterPro
NV2t004756001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t004756001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t004756001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004756001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t004758001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t004758001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004758001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t004758001.1	molecular_function	GO:0000062	fatty-acyl-CoA binding	"Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]	InterPro
NV2t004758001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t004758001.1	molecular_function	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3.-, GOC:mah]	OMA
NV2t004758001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t004758001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t004758001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t004758001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t004759001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t004759001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t004761001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t004761001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004783001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004783002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004783003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t004786001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t004787001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t004787001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t004787001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t004787001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004787001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004787001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004787001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t004787001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t004787001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t004788001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t004788001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t004790001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t004790001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	OMA
NV2t004790001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004790001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004790001.1	molecular_function	GO:0034458	3'-5' RNA helicase activity	"Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis." [GOC:jp]	PANTHER
NV2t004792001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004793001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004794001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t004794001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004799001.1	biological_process	GO:0002347	response to tumor cell	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]	OMA
NV2t004799001.1	biological_process	GO:0009913	epidermal cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]	OMA
NV2t004799001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t004799001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t004799001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t004799001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t004799001.1	biological_process	GO:0051302	regulation of cell division	"Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]	OMA
NV2t004799001.1	biological_process	GO:0071216	cellular response to biotic stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]	OMA
NV2t004799001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004799001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t004801001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004804001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004804001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t004804001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t004804001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004804001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004804001.1	molecular_function	GO:0004683	calmodulin-dependent protein kinase activity	"Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah, PMID:11264466]	OMA
NV2t004804001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t004804001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004804001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004804002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004804002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004805001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004805001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t004805001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t004805002.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t004805002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004805002.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t004805002.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t004805002.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004805002.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004805002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t004805002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t004805003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004805003.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t004805003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t004805005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004805005.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t004805005.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t004806001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t004806001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t004806001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t004806001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t004806001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004806001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004806001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t004806001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t004806001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t004807001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004807002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004808001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	OMA
NV2t004808001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t004808001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t004808001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t004808001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t004808002.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t004809001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004810001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004810001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004810002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004810003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004812001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	PANTHER
NV2t004812001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004813002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t004813002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004813002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t004813002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004825001.1	biological_process	GO:0007043	cell-cell junction assembly	"The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]	OMA
NV2t004825001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t004825001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	PANTHER
NV2t004825001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t004825001.1	biological_process	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	OMA
NV2t004825001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004825001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t004825001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t004825001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t004825001.1	molecular_function	GO:0005080	protein kinase C binding	"Binding to protein kinase C." [GOC:jl]	OMA
NV2t004825001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004825002.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	PANTHER
NV2t004825002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004826001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004826002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004826002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t004826002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004827001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004827001.1	biological_process	GO:0030707	follicle cell of egg chamber development	"The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]	OMA
NV2t004827001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t004827001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	OMA
NV2t004827001.1	cellular_component	GO:0000791	euchromatin	"A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]	OMA
NV2t004827001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004827001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004827001.1	molecular_function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	"Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene." [GOC:pg, GOC:txnOH, PMID:12381658]	OMA
NV2t004827001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t004827001.1	molecular_function	GO:0001223	transcription coactivator binding	"Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc]	OMA
NV2t004827001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004827002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004827003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004827004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004828001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004828002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004829001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004829001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t004830001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004832001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t004832001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t004832001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t004832001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004832001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004832001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004832002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t004832002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004833001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t004833001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t004833001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t004833001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t004834001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004834001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t004835001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004835001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t004846001.1	biological_process	GO:0051013	microtubule severing	"The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends." [GOC:ai, PMID:27037673]	InterPro
NV2t004846001.1	cellular_component	GO:0008352	katanin complex	"A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]	PANTHER
NV2t004846001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004846001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t004847001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t004847001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t004847001.1	biological_process	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t004847001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t004847001.1	biological_process	GO:0010720	positive regulation of cell development	"Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t004847001.1	biological_process	GO:0010721	negative regulation of cell development	"Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t004847001.1	biological_process	GO:0022408	negative regulation of cell-cell adhesion	"Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t004847001.1	biological_process	GO:0022409	positive regulation of cell-cell adhesion	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t004847001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t004847001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t004847001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t004847001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t004847001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t004847001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t004847001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t004847001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t004847001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004847001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t004847001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t004848001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004849001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t004849001.1	biological_process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t004849001.1	biological_process	GO:0034728	nucleosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah]	OMA
NV2t004849001.1	cellular_component	GO:0035101	FACT complex	"A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage." [PMID:12934006, PMID:12934007, PMID:16678108, PMID:34731638]	InterPro
NV2t004849001.1	cellular_component	GO:0035101	FACT complex	"A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage." [PMID:12934006, PMID:12934007, PMID:16678108, PMID:34731638]	OMA
NV2t004849001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004849001.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	OMA
NV2t004851001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t004851001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004852001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004852001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t004853001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t004853001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t004853001.1	biological_process	GO:1901673	regulation of mitotic spindle assembly	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]	OMA
NV2t004853001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t004853001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004853001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t004853001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t004854001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	OMA
NV2t004854001.1	biological_process	GO:0034389	lipid droplet organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]	InterPro
NV2t004854001.1	biological_process	GO:0034389	lipid droplet organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]	OMA
NV2t004854001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004854001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t004854001.1	molecular_function	GO:0106399	obsolete acyl-coenzyme A diphosphatase activity	"OBSOLETE. Catalysis of the reaction: an acyl-coenzyme A + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+." [PMID:32915949]	InterPro
NV2t004855001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004855001.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	OMA
NV2t004855001.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	PANTHER
NV2t004856001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004856001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004856001.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	OMA
NV2t004856001.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	PANTHER
NV2t004856003.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	InterPro
NV2t004856003.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	PANTHER
NV2t004856004.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	InterPro
NV2t004856004.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	PANTHER
NV2t004856005.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	PANTHER
NV2t004858001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004858002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004859001.1	molecular_function	GO:1905762	CCR4-NOT complex binding	"Binding to a CCR4-NOT complex." [GOC:TermGenie, PMID:26942678]	PANTHER
NV2t004859002.1	molecular_function	GO:1905762	CCR4-NOT complex binding	"Binding to a CCR4-NOT complex." [GOC:TermGenie, PMID:26942678]	PANTHER
NV2t004860001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t004860001.1	biological_process	GO:0008152	metabolic process	"The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t004860001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t004860001.1	biological_process	GO:0048213	obsolete Golgi vesicle prefusion complex stabilization	"OBSOLETE. The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jid, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t004860001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t004860001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	OMA
NV2t004860002.1	biological_process	GO:0048213	obsolete Golgi vesicle prefusion complex stabilization	"OBSOLETE. The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jid, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t004860003.1	biological_process	GO:0048213	obsolete Golgi vesicle prefusion complex stabilization	"OBSOLETE. The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jid, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t004861001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t004861001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	PANTHER
NV2t004862001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t004862001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t004862001.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	InterPro
NV2t004862001.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t004862001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t004862001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	OMA
NV2t004862001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t004862002.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	InterPro
NV2t004862002.1	cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t004864001.1	biological_process	GO:0016925	protein sumoylation	"The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]	OMA
NV2t004864001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t004864001.1	biological_process	GO:0033233	regulation of protein sumoylation	"Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]	OMA
NV2t004864001.1	biological_process	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t004864001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004864001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t004864001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t004864001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t004864001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004864001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t004864001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	OMA
NV2t004864001.1	molecular_function	GO:0019948	SUMO activating enzyme activity	"Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250]	InterPro
NV2t004864001.1	molecular_function	GO:0032183	SUMO binding	"Binding to the small ubiquitin-like protein SUMO." [GOC:mah]	OMA
NV2t004864001.1	molecular_function	GO:0044388	small protein activating enzyme binding	"Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme." [GOC:jl]	OMA
NV2t004864001.1	molecular_function	GO:0044390	ubiquitin-like protein conjugating enzyme binding	"Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme." [GOC:jl]	OMA
NV2t004864001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t004864002.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t004864002.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t004864002.1	molecular_function	GO:0019948	SUMO activating enzyme activity	"Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250]	InterPro
NV2t004865001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t004865001.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	InterPro
NV2t004865001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	OMA
NV2t004865001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t004865001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t004866001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t004866001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t004866001.1	biological_process	GO:1905267	obsolete endonucleolytic cleavage involved in tRNA processing	"OBSOLETE. Any endonucleolytic RNA phosphodiester bond hydrolysis that is involved in tRNA processing." [GO_REF:0000060, GOC:TermGenie, PMID:25401760]	OMA
NV2t004866001.1	biological_process	GO:1905267	obsolete endonucleolytic cleavage involved in tRNA processing	"OBSOLETE. Any endonucleolytic RNA phosphodiester bond hydrolysis that is involved in tRNA processing." [GO_REF:0000060, GOC:TermGenie, PMID:25401760]	PANTHER
NV2t004866001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	InterPro
NV2t004866001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	OMA
NV2t004866001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t004866001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t004866001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t004867001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t004869001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	OMA
NV2t004869001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t004869001.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t004869001.1	cellular_component	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	"A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]	OMA
NV2t004869002.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t004870001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	PANTHER
NV2t004870002.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	PANTHER
NV2t004870003.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	PANTHER
NV2t004872001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t004872001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t004872001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t004873001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t004873001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004873002.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t004873002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004874001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004874001.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t004874002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004874002.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t004874003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004874003.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t004874004.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t004874004.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t004874005.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t004874006.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t004876001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004877001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004877001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t004877001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004877002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004877002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004877003.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004877003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004877004.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004877004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004877005.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004877005.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004879001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004879001.1	biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t004879001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t004879001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t004881001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t004881001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	InterPro
NV2t004881001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t004881001.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	PANTHER
NV2t004881001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t004881001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t004882001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t004882001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t004882001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t004882001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004882001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004882002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t004882002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004884001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004885001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t004885001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t004885001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t004885001.1	biological_process	GO:0106035	protein maturation by [4Fe-4S] cluster transfer	"The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]	InterPro
NV2t004885001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004885001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004885001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t004885001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t004885001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004887001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004887001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004887001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004887002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004888001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t004888001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004889001.1	molecular_function	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]	PANTHER
NV2t004889002.1	molecular_function	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]	PANTHER
NV2t004890001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t004890001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t004890001.1	molecular_function	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	"Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920]	InterPro
NV2t004890001.1	molecular_function	GO:0008113	peptide-methionine (S)-S-oxide reductase activity	"Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920]	OMA
NV2t004892001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t004892001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004892001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004892001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t004894001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t004894001.1	biological_process	GO:0016267	O-glycan processing, core 1	"The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]	OMA
NV2t004894001.1	biological_process	GO:0016267	O-glycan processing, core 1	"The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]	PANTHER
NV2t004894001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t004894001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004894001.1	molecular_function	GO:0016263	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	"Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma]	OMA
NV2t004894001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t004895001.1	biological_process	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	OMA
NV2t004895001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t004895001.1	biological_process	GO:0051347	positive regulation of transferase activity	"Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]	OMA
NV2t004895001.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	OMA
NV2t004895001.1	cellular_component	GO:0042405	nuclear inclusion body	"An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl]	OMA
NV2t004895001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t004895001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004895001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t004895001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t004895001.1	molecular_function	GO:0008143	poly(A) binding	"Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]	PANTHER
NV2t004895001.1	molecular_function	GO:0070063	RNA polymerase binding	"Binding to an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH]	OMA
NV2t004896001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t004896001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004896001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004896001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t004896001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t004898001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004898001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t004898001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t004898001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t004900001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004900001.1	biological_process	GO:0098754	detoxification	"Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos]	OMA
NV2t004900001.1	biological_process	GO:0140115	export across plasma membrane	"The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg]	OMA
NV2t004900001.1	biological_process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	"A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell." [PMID:28355133]	InterPro
NV2t004900001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t004900001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t004900001.1	molecular_function	GO:0015101	organic cation transmembrane transporter activity	"Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004900001.1	molecular_function	GO:0015174	basic amino acid transmembrane transporter activity	"Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004900001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t004900001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t004900001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t004900001.1	molecular_function	GO:0042910	xenobiotic transmembrane transporter activity	"Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators, GOC:krc]	OMA
NV2t004900001.1	molecular_function	GO:0072349	modified amino acid transmembrane transporter activity	"Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah]	OMA
NV2t004901001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t004903001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004903001.1	molecular_function	GO:1990450	linear polyubiquitin binding	"Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next." [GOC:bf, GOC:PARL, PMID:23453807]	PANTHER
NV2t004904001.1	biological_process	GO:0001764	neuron migration	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]	OMA
NV2t004904001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	OMA
NV2t004904001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t004904001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004904001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t004904001.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	OMA
NV2t004904001.1	molecular_function	GO:0097363	protein O-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438]	PANTHER
NV2t004905001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t004905001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t004905001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t004905001.1	biological_process	GO:0031324	negative regulation of cellular metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t004905001.1	biological_process	GO:0051302	regulation of cell division	"Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]	OMA
NV2t004905001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004905001.1	biological_process	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	OMA
NV2t004905001.1	biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t004905001.1	biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	PANTHER
NV2t004905001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t004905001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004905001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t004905001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t004905001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t004905002.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004905002.1	biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	PANTHER
NV2t004905003.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t004905003.1	biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	PANTHER
NV2t004906001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t004906001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t004906001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t004906001.1	molecular_function	GO:0015929	hexosaminidase activity	"Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544]	OMA
NV2t004907001.1	cellular_component	GO:1990112	RQC complex	"A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins." [GOC:rb, PMID:23178123, PMID:23232563]	PANTHER
NV2t004907002.1	cellular_component	GO:1990112	RQC complex	"A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins." [GOC:rb, PMID:23178123, PMID:23232563]	PANTHER
NV2t004908001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004908001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t004908001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t004908001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004908001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004909001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004909002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004909002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004909002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004909003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t004909003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004909003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t004911001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t004911001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t004911001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t004911001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t004911001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t004911001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t004911001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t004913001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t004913001.1	biological_process	GO:0070212	protein poly-ADP-ribosylation	"The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain." [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]	OMA
NV2t004913001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t004913001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t004913001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t004913001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t004913001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004913001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004913001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	OMA
NV2t004913001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	PANTHER
NV2t004914001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004914002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004915001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004915001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t004916001.1	biological_process	GO:1902775	mitochondrial large ribosomal subunit assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit." [GO_REF:0000079, GOC:TermGenie, PMID:24206665]	PANTHER
NV2t004916001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t004916001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t004916001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004917001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t004917001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t004917001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t004917001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t004917001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t004921001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t004921001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	InterPro
NV2t004921001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t004921001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004921001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004921001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004929001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t004929001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t004929001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004929001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004929001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004932001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t004932001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004933001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t004933001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t004933001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004933002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t004933002.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t004933002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004933003.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t004933003.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t004933003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004933004.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t004933004.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t004933004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004933005.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t004933005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004934001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	InterPro
NV2t004934001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t004934001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t004934001.1	cellular_component	GO:0016342	catenin complex	"Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]	OMA
NV2t004934001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t004934001.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	OMA
NV2t004935001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	PANTHER
NV2t004935001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t004935001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t004937001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	PANTHER
NV2t004937001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t004937001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004938001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004940001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	OMA
NV2t004940001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t004940001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t004940001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t004940001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t004940001.1	biological_process	GO:0031648	protein destabilization	"Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]	OMA
NV2t004940001.1	biological_process	GO:0032092	positive regulation of protein binding	"Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t004940001.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	OMA
NV2t004940001.1	cellular_component	GO:0000153	cytoplasmic ubiquitin ligase complex	"A ubiquitin ligase complex found in the cytoplasm." [GOC:mah]	OMA
NV2t004940001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t004940001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t004940001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t004940001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t004940001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t004940001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t004940001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t004940001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t004940001.1	molecular_function	GO:1990381	ubiquitin-specific protease binding	"Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]	OMA
NV2t004940001.1	molecular_function	GO:1990381	ubiquitin-specific protease binding	"Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]	PANTHER
NV2t004941001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t004941001.1	biological_process	GO:0043401	steroid hormone mediated signaling pathway	"The series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	OMA
NV2t004941001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t004941001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t004941001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004941001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	InterPro
NV2t004941001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t004941001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004941001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004941001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t004941001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t004941001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t004941002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t004941002.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	InterPro
NV2t004941002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004941002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t004942001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t004942001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t004942001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t004942001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004943001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	OMA
NV2t004943001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	OMA
NV2t004943001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	PANTHER
NV2t004943001.1	molecular_function	GO:0032977	membrane insertase activity	"Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]	OMA
NV2t004944001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t004944001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t004944001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t004944001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t004947001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004947001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t004947001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004947001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004948001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t004953001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t004955001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004955001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t004960001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t004960001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t004960001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t004960001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t004960001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004960001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t004960001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t004962001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004962001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004963001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t004963001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t004965001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004965001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	PANTHER
NV2t004965001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004965002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004965002.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	PANTHER
NV2t004965002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004965003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004965003.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	PANTHER
NV2t004965003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004965004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004965004.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	PANTHER
NV2t004965004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004965005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004965005.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	PANTHER
NV2t004965005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004965006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t004965006.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	PANTHER
NV2t004965006.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004966001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t004966001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t004966001.1	cellular_component	GO:0030121	AP-1 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]	InterPro
NV2t004966001.1	molecular_function	GO:0140312	cargo adaptor activity	"Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]	PANTHER
NV2t004978001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t004978001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004978002.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t004978002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t004979001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t004979001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004979001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004979001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t004979002.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t004979002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004979002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004979002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t004980001.1	molecular_function	GO:0004800	thyroxine 5'-deiodinase activity	"Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.21.99.4]	InterPro
NV2t004980001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t004985001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t004985001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t004985001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t004985001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004986001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004986002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t004987001.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t004990001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004990002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004990002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t004990002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t004990003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t004991001.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t004991001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t004991001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t004991001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t004991001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t004991001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t004991001.1	cellular_component	GO:0097733	photoreceptor cell cilium	"A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment." [GOC:cilia, Wikipedia:Photoreceptor_cell#Histology]	OMA
NV2t004991001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t004993001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t004993001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004993002.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t004993002.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t004993002.1	biological_process	GO:0010822	obsolete positive regulation of mitochondrion organization	"OBSOLETE. Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	OMA
NV2t004993002.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t004993002.1	biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t004993002.1	biological_process	GO:0071560	cellular response to transforming growth factor beta stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]	OMA
NV2t004993002.1	biological_process	GO:0090316	positive regulation of intracellular protein transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t004993002.1	biological_process	GO:1903644	regulation of chaperone-mediated protein folding	"Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412]	OMA
NV2t004993002.1	biological_process	GO:1905477	positive regulation of protein localization to membrane	"Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	OMA
NV2t004993002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t004993002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t004993002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t004993002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t004993002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t004993002.1	molecular_function	GO:0008201	heparin binding	"Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t004993002.1	molecular_function	GO:0010698	acetyltransferase activator activity	"Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:23912279]	OMA
NV2t004993002.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	OMA
NV2t004999001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t004999001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005000001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t005000001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t005000001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t005001001.1	biological_process	GO:0006553	lysine metabolic process	"The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]	OMA
NV2t005001001.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t005001001.1	biological_process	GO:0009085	lysine biosynthetic process	"The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]	InterPro
NV2t005001001.1	biological_process	GO:0019878	lysine biosynthetic process via aminoadipic acid	"The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators]	PANTHER
NV2t005001001.1	molecular_function	GO:0004754	saccharopine dehydrogenase (NAD+, L-lysine-forming) activity	"Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH." [EC:1.5.1.7, RHEA:12440]	OMA
NV2t005001002.1	biological_process	GO:0009085	lysine biosynthetic process	"The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]	InterPro
NV2t005001002.1	biological_process	GO:0019878	lysine biosynthetic process via aminoadipic acid	"The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators]	PANTHER
NV2t005002001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t005002001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t005002002.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t005003001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t005003003.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t005004001.1	biological_process	GO:0006553	lysine metabolic process	"The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]	OMA
NV2t005004001.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t005004001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005004001.1	molecular_function	GO:0004753	saccharopine dehydrogenase activity	"Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah]	OMA
NV2t005004001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t005015001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t005015001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005015001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005015001.1	molecular_function	GO:0008417	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t005015001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t005018001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t005018001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t005018001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t005018001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005018001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t005018001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t005023001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005023001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005026001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005026001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005026001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005026001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005031001.1	molecular_function	GO:0015067	amidinotransferase activity	"Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai]	PANTHER
NV2t005033001.1	biological_process	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t005033001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t005033001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t005033001.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t005033001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t005033001.1	molecular_function	GO:0015067	amidinotransferase activity	"Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai]	PANTHER
NV2t005033001.1	molecular_function	GO:0016741	transferase activity, transferring one-carbon groups	"Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t005036001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t005036001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t005036001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005036001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t005036001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t005037001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005038001.1	molecular_function	GO:0070573	metallodipeptidase activity	"Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005038002.1	biological_process	GO:0000096	sulfur amino acid metabolic process	"The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]	OMA
NV2t005038002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t005038002.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t005038002.1	biological_process	GO:0006690	icosanoid metabolic process	"The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma]	OMA
NV2t005038002.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t005038002.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t005038002.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t005038002.1	biological_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t005038002.1	biological_process	GO:0044273	sulfur compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]	OMA
NV2t005038002.1	biological_process	GO:0046395	carboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t005038002.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t005038002.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t005038002.1	biological_process	GO:0071466	cellular response to xenobiotic stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:krc, GOC:mah]	OMA
NV2t005038002.1	biological_process	GO:0071731	response to nitric oxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf]	OMA
NV2t005038002.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t005038002.1	biological_process	GO:1901568	fatty acid derivative metabolic process	"The chemical reactions and pathways involving fatty acid derivative." [GOC:pr, GOC:TermGenie]	OMA
NV2t005038002.1	biological_process	GO:1901605	alpha-amino acid metabolic process	"The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t005038002.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t005038002.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t005038002.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t005038002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t005038002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005038002.1	cellular_component	GO:0045177	apical part of cell	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]	OMA
NV2t005038002.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	OMA
NV2t005038002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005038002.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	OMA
NV2t005038002.1	molecular_function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	OMA
NV2t005038002.1	molecular_function	GO:0034235	GPI anchor binding	"Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]	OMA
NV2t005038002.1	molecular_function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]	OMA
NV2t005038002.1	molecular_function	GO:0070573	metallodipeptidase activity	"Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005038002.1	molecular_function	GO:0072341	modified amino acid binding	"Binding to a modified amino acid." [GOC:mah]	OMA
NV2t005039001.1	molecular_function	GO:0070573	metallodipeptidase activity	"Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005040001.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t005040001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t005040001.1	biological_process	GO:0060295	regulation of cilium movement involved in cell motility	"Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t005040001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t005040001.1	biological_process	GO:2000147	positive regulation of cell motility	"Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah]	OMA
NV2t005040001.1	biological_process	GO:2000147	positive regulation of cell motility	"Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah]	PANTHER
NV2t005040001.1	biological_process	GO:2000253	positive regulation of feeding behavior	"Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]	OMA
NV2t005040001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t005040001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t005040001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t005040001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t005040001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t005040001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t005042001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t005042002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t005042002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t005042002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t005042002.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t005042002.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t005043001.1	cellular_component	GO:0097526	spliceosomal tri-snRNP complex	"A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]	PANTHER
NV2t005043002.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	InterPro
NV2t005043002.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t005043002.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t005043002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005043002.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t005043002.1	cellular_component	GO:0034719	SMN-Sm protein complex	"A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408]	OMA
NV2t005043002.1	cellular_component	GO:0097526	spliceosomal tri-snRNP complex	"A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]	PANTHER
NV2t005043002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005043002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t005044001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005045001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t005045001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005048001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t005048001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005051001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t005051001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005052001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t005052001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005052001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005052001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t005054001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t005054001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005056001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t005057001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t005057001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005057001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005057002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005058001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t005058001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	OMA
NV2t005058001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	PANTHER
NV2t005059001.1	biological_process	GO:0019646	aerobic electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]	OMA
NV2t005059001.1	biological_process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]	OMA
NV2t005059001.1	cellular_component	GO:0005746	mitochondrial respirasome	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]	OMA
NV2t005059001.1	cellular_component	GO:0070069	cytochrome complex	"A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah]	OMA
NV2t005059001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t005059001.1	cellular_component	GO:0098803	respiratory chain complex	"Any protein complex that is part of a respiratory chain." [GOC:dos]	OMA
NV2t005059001.1	cellular_component	GO:1902495	transmembrane transporter complex	"A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586]	OMA
NV2t005059001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t005059001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t005059001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t005059001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t005059001.1	molecular_function	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	"Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t005059001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005059001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t005059001.1	molecular_function	GO:0022853	active monoatomic ion transmembrane transporter activity	"Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005061001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005061001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t005061001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	InterPro
NV2t005061001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t005061001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t005061001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t005061001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005061001.1	molecular_function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	"Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]	OMA
NV2t005061001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005061001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005061001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005062001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t005062002.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t005062002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t005062002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005063001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t005063001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t005063001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005063002.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	OMA
NV2t005063002.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t005063002.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t005063002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t005063002.1	cellular_component	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	"A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]	OMA
NV2t005063002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005063002.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t005063002.1	molecular_function	GO:0035925	mRNA 3'-UTR AU-rich region binding	"Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]	OMA
NV2t005065001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005065001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t005065001.1	molecular_function	GO:0030151	molybdenum ion binding	"Binding to a molybdenum ion (Mo)." [GOC:ai]	InterPro
NV2t005065001.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t005065001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t005065001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t005065001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t005070001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t005070001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t005070001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t005071001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t005071001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t005071001.1	biological_process	GO:0006268	DNA unwinding involved in DNA replication	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]	OMA
NV2t005071001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t005071001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t005071001.1	biological_process	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	OMA
NV2t005071001.1	biological_process	GO:1902975	mitotic DNA replication initiation	"Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]	PANTHER
NV2t005071001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	InterPro
NV2t005071001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	OMA
NV2t005071001.1	cellular_component	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	OMA
NV2t005071001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t005071001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005071001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005071001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005071001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t005073001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t005075001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005075001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t005075001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005075001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005075001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005076001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t005076002.1	biological_process	GO:0010891	negative regulation of sequestering of triglyceride	"Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t005076002.1	biological_process	GO:0010898	positive regulation of triglyceride catabolic process	"Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]	OMA
NV2t005076002.1	biological_process	GO:0046473	phosphatidic acid metabolic process	"The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]	OMA
NV2t005076002.1	biological_process	GO:0046474	glycerophospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t005076002.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t005076002.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t005076002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t005076002.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t005076002.1	molecular_function	GO:0042171	lysophosphatidic acid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]	OMA
NV2t005076002.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t005077001.1	biological_process	GO:0006892	post-Golgi vesicle-mediated transport	"The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]	OMA
NV2t005077001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t005077001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t005077001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005077001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005077001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005077001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t005077001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005078001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t005078001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005078001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005078001.1	biological_process	GO:0051497	negative regulation of stress fiber assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	OMA
NV2t005078001.1	biological_process	GO:0051497	negative regulation of stress fiber assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	PANTHER
NV2t005078001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t005078001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005080001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005080001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005081001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t005081001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005082001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005082001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t005083001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005085001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t005085001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t005085001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t005085001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	PANTHER
NV2t005085001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t005085001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t005085001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005085001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005085001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t005085001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t005085001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t005085002.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	PANTHER
NV2t005085002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005085002.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t005085003.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	PANTHER
NV2t005085003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005085003.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t005086002.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	PANTHER
NV2t005088001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t005088001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005088001.1	cellular_component	GO:1990604	IRE1-TRAF2-ASK1 complex	"A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K)." [GOC:bf, GOC:PARL, PMID:12050113, PMID:23000344]	PANTHER
NV2t005088001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005088001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005089001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089002.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089002.1	cellular_component	GO:0031105	septin complex	"A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632]	OMA
NV2t005089002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t005089003.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089004.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089005.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089006.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089006.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089007.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089007.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089008.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089008.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089009.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089009.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089010.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089010.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089011.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089011.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089012.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089012.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089013.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089013.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005089014.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t005089014.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005093001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t005093001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t005094001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005097001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t005097001.1	cellular_component	GO:0097431	mitotic spindle pole	"Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]	PANTHER
NV2t005097001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005100001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t005100001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005100001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005100001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t005100001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t005100001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t005100001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t005100001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t005100001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t005100001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t005101001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	OMA
NV2t005101001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	PANTHER
NV2t005101001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t005101001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t005101001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t005106001.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	PANTHER
NV2t005106001.1	biological_process	GO:0042732	D-xylose metabolic process	"The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]	InterPro
NV2t005106001.1	biological_process	GO:0042732	D-xylose metabolic process	"The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]	OMA
NV2t005106001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t005106001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t005106001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005106001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t005106001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t005106001.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t005107001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005107001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t005107002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t005108001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t005108001.1	molecular_function	GO:1990050	phosphatidic acid transfer activity	"Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]	OMA
NV2t005108001.1	molecular_function	GO:1990050	phosphatidic acid transfer activity	"Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]	PANTHER
NV2t005109001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005111001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t005114001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005124002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t005124002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t005124002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t005124002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t005124003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t005124003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t005124004.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t005124004.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t005125001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t005125001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t005125001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t005125001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t005125001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005125001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005125001.1	molecular_function	GO:0031624	ubiquitin conjugating enzyme binding	"Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]	OMA
NV2t005125001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t005125001.1	molecular_function	GO:1990381	ubiquitin-specific protease binding	"Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]	OMA
NV2t005126001.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t005126001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t005126001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t005126001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005126001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005128001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t005128001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t005128001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t005128001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t005128001.1	cellular_component	GO:0005801	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	OMA
NV2t005128001.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	OMA
NV2t005128001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t005128001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t005128001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t005128001.1	molecular_function	GO:0034235	GPI anchor binding	"Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]	OMA
NV2t005128001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t005129001.1	biological_process	GO:0019510	S-adenosylhomocysteine catabolic process	"The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732]	OMA
NV2t005129001.1	biological_process	GO:0033353	S-adenosylmethionine cycle	"A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]	OMA
NV2t005129001.1	biological_process	GO:0033353	S-adenosylmethionine cycle	"A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]	PANTHER
NV2t005129001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005129001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t005129001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t005130001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t005130001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005130001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t005131001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t005131001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t005131002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t005131002.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t005133001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005133001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t005133001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t005133001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t005133001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005136001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t005136001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005136001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t005136001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t005136001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t005136001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t005136001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t005136001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t005136001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t005137001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t005137001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005137001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t005137001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t005137001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t005137001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t005137001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t005137001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t005137001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t005138001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t005138001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005138001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005138001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t005138001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t005138001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t005138001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t005138001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t005138001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t005138001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t005139001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005139002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005139003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t005139003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t005139003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005141001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005141001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t005141001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005141001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005141002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005141002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t005141002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005141002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005141003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005141003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t005141003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005141003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005141004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005141004.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t005141004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005141004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005141005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005141005.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t005141005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005141005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005142001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t005142002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t005143001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t005143001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t005143001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	InterPro
NV2t005143001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	OMA
NV2t005143002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t005143002.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	InterPro
NV2t005145001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005145001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005145001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005147001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t005147001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t005150001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	PANTHER
NV2t005150001.1	molecular_function	GO:0032977	membrane insertase activity	"Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]	OMA
NV2t005152001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005152001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t005152001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005152001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005154001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005154001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t005156001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005156001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t005160001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	PANTHER
NV2t005160002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t005160002.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	InterPro
NV2t005160002.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	OMA
NV2t005160002.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	PANTHER
NV2t005161001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t005161001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t005161001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t005161001.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t005161001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t005161001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t005166001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t005166002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005166002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t005169001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t005169001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t005169001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t005169001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t005169001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t005169001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t005171001.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t005171001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005171001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t005171001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005171002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005171003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005171003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005171004.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t005171004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005171005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005171006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005171006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005171007.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005171007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005173001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t005176001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	InterPro
NV2t005176001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	OMA
NV2t005176001.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	OMA
NV2t005176001.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	OMA
NV2t005176001.1	biological_process	GO:1900363	obsolete regulation of mRNA polyadenylation	"OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841]	OMA
NV2t005176001.1	biological_process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	"Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]	OMA
NV2t005176001.1	biological_process	GO:1903313	positive regulation of mRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t005176001.1	biological_process	GO:1990120	obsolete messenger ribonucleoprotein complex assembly	"OBSOLETE. The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex." [GOC:rb, PMID:23721653]	OMA
NV2t005176001.1	biological_process	GO:2000738	positive regulation of stem cell differentiation	"Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol]	OMA
NV2t005176001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005176001.1	cellular_component	GO:0005849	mRNA cleavage factor complex	"Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856]	OMA
NV2t005176001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t005176001.1	molecular_function	GO:0017091	mRNA 3'-UTR AU-rich region binding	"Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]	PANTHER
NV2t005176001.1	molecular_function	GO:0035925	mRNA 3'-UTR AU-rich region binding	"Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]	OMA
NV2t005176001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t005176002.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	InterPro
NV2t005176002.1	molecular_function	GO:0017091	mRNA 3'-UTR AU-rich region binding	"Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]	PANTHER
NV2t005178001.1	biological_process	GO:0018242	protein O-linked glycosylation via serine	"The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154]	OMA
NV2t005178001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t005178001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005178001.1	molecular_function	GO:0035251	UDP-glucosyltransferase activity	"Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [PMID:19858195]	OMA
NV2t005178001.1	molecular_function	GO:0035252	UDP-xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [PMID:30127001]	OMA
NV2t005178001.1	molecular_function	GO:0046527	glucosyltransferase activity	"Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	PANTHER
NV2t005179001.1	biological_process	GO:0006622	protein targeting to lysosome	"The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators]	OMA
NV2t005179001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t005179001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	OMA
NV2t005179001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t005179001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t005179001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t005179001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t005179001.1	cellular_component	GO:0031312	extrinsic component of organelle membrane	"The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]	OMA
NV2t005179001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005179001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t005179002.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t005179002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005181001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t005181002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t005181002.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t005181002.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t005181002.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t005181002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005182001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005182001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t005182001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t005183001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005183001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t005183001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t005186001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	PANTHER
NV2t005186001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005186002.1	biological_process	GO:0071896	protein localization to adherens junction	"Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237]	OMA
NV2t005186002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005186002.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t005186002.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	PANTHER
NV2t005186002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005186003.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	PANTHER
NV2t005186003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005187001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t005187001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t005187001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t005187001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t005187001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t005187001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t005187002.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t005187003.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t005188001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t005188001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005188002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005189001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005194001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005196001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005196002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t005196002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005196003.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005196004.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005199001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005199001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t005199002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005200001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t005200001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t005200001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t005200001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t005200001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t005200001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005200001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t005202001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t005202001.1	biological_process	GO:0032098	regulation of appetite	"Any process which modulates appetite, the desire or physical craving for food." [GOC:add]	OMA
NV2t005202001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005202001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005202001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t005202001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t005202001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t005202001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005202002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005202002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005202003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005202003.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005202004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005202004.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005203001.1	biological_process	GO:0001894	tissue homeostasis	"A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]	OMA
NV2t005203001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t005203001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t005203001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t005203001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t005203001.1	biological_process	GO:0007080	mitotic metaphase chromosome alignment	"A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [ISBN:0815316194]	OMA
NV2t005203001.1	biological_process	GO:0010458	exit from mitosis	"The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]	OMA
NV2t005203001.1	biological_process	GO:0010639	negative regulation of organelle organization	"Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	OMA
NV2t005203001.1	biological_process	GO:0010824	regulation of centrosome duplication	"Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]	OMA
NV2t005203001.1	biological_process	GO:0016242	negative regulation of macroautophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]	OMA
NV2t005203001.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t005203001.1	biological_process	GO:0031468	nuclear membrane reassembly	"The reformation of the nuclear membranes following their breakdown in the context of a normal process." [GOC:mah]	OMA
NV2t005203001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t005203001.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t005203001.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t005203001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t005203001.1	biological_process	GO:0044000	obsolete movement in host	"OBSOLETE. The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]	OMA
NV2t005203001.1	biological_process	GO:0051258	protein polymerization	"The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]	OMA
NV2t005203001.1	biological_process	GO:0061952	midbody abscission	"The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells." [PMID:12737809, PMID:29903934]	OMA
NV2t005203001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t005203001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t005203001.1	biological_process	GO:0090148	membrane fission	"A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t005203001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t005203001.1	biological_process	GO:1901215	obsolete negative regulation of neuron death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t005203001.1	biological_process	GO:1901673	regulation of mitotic spindle assembly	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]	OMA
NV2t005203001.1	biological_process	GO:1902774	late endosome to lysosome transport	"The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442]	OMA
NV2t005203001.1	biological_process	GO:2000785	regulation of autophagosome assembly	"Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t005203001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t005203001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t005203001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t005203001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t005203001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t005203001.1	cellular_component	GO:0005828	kinetochore microtubule	"Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]	OMA
NV2t005203001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t005203001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	OMA
NV2t005203001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t005203001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t005203001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t005203001.1	cellular_component	GO:0044753	amphisome	"Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]	OMA
NV2t005203001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t005204001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t005204001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t005204001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	OMA
NV2t005204001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005204001.1	molecular_function	GO:0017057	6-phosphogluconolactonase activity	"Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+." [EC:3.1.1.31, RHEA:12556]	InterPro
NV2t005204001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t005205001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005205001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005205001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005205001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t005207001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t005208001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t005208001.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	OMA
NV2t005208001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005208001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t005208001.1	molecular_function	GO:0004525	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	OMA
NV2t005210001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005210001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005210001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t005211001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t005211001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t005212001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t005212001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	OMA
NV2t005212001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	OMA
NV2t005212001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005212001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t005212001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005212001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t005212001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t005212001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t005212001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t005212001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t005212001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t005212001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	OMA
NV2t005212001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005212001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005212001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005212001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t005212001.1	molecular_function	GO:0008143	poly(A) binding	"Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]	OMA
NV2t005215001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t005215001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t005217001.1	biological_process	GO:1904158	axonemal central apparatus assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:9295136]	PANTHER
NV2t005218001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005218001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005218001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005219001.1	biological_process	GO:1904158	axonemal central apparatus assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:9295136]	PANTHER
NV2t005220001.1	molecular_function	GO:0080132	fatty acid alpha-hydroxylase activity	"Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain." [PMID:19054355]	PANTHER
NV2t005222001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005222001.1	molecular_function	GO:0080132	fatty acid alpha-hydroxylase activity	"Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain." [PMID:19054355]	PANTHER
NV2t005227001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t005227001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t005227001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t005228001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005228001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005231001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t005231001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t005231001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	PANTHER
NV2t005231001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t005232001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t005232001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005235001.1	biological_process	GO:0009082	branched-chain amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	PANTHER
NV2t005235001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t005235001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	InterPro
NV2t005237001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t005237001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t005237001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t005240001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t005240001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005240001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t005240001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t005240001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005240001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t005242001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005242001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t005242001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t005242001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t005242002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t005242002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t005242003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005242003.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t005242003.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t005242005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005247001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t005247001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	PANTHER
NV2t005247001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t005247001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t005248001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t005248001.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t005248001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t005248001.1	biological_process	GO:0070201	regulation of establishment of protein localization	"Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]	OMA
NV2t005248001.1	biological_process	GO:0070202	regulation of establishment of protein localization to chromosome	"Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]	PANTHER
NV2t005248001.1	biological_process	GO:0071241	cellular response to inorganic substance	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah]	OMA
NV2t005248001.1	biological_process	GO:0071312	cellular response to alkaloid	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah]	OMA
NV2t005248001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t005248001.1	biological_process	GO:0071479	cellular response to ionizing radiation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]	OMA
NV2t005248001.1	biological_process	GO:0097306	cellular response to alcohol	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr]	OMA
NV2t005248001.1	biological_process	GO:1901563	response to camptothecin	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie]	OMA
NV2t005248001.1	biological_process	GO:2000781	positive regulation of double-strand break repair	"Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t005248001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t005248001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t005251001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	OMA
NV2t005251001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	InterPro
NV2t005251001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	OMA
NV2t005251001.1	molecular_function	GO:0032977	membrane insertase activity	"Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]	OMA
NV2t005255001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t005255001.1	biological_process	GO:0036071	N-glycan fucosylation	"The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [GOC:sart, PMID:19948734]	OMA
NV2t005255001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	OMA
NV2t005255001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t005256001.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t005256002.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	PANTHER
NV2t005257001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t005257001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005257002.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t005257002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005257003.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t005257003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005257004.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t005257004.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005257005.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t005257005.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005257006.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t005257006.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005258001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005258002.1	biological_process	GO:0010637	negative regulation of mitochondrial fusion	"Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]	OMA
NV2t005258002.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t005258002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005258002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005258002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t005258003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005258004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005261001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t005261001.1	biological_process	GO:0006637	acyl-CoA metabolic process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]	OMA
NV2t005261001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	InterPro
NV2t005261001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t005261001.1	molecular_function	GO:0047617	fatty acyl-CoA hydrolase activity	"Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+." [RHEA:16781]	PANTHER
NV2t005263001.1	biological_process	GO:0000154	rRNA modification	"The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t005263001.1	biological_process	GO:0001522	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule." [GOC:hjd, GOC:mah]	OMA
NV2t005263001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t005263001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t005263001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	PANTHER
NV2t005263001.1	molecular_function	GO:0016866	intramolecular transferase activity	"Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t005264001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t005264001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t005264001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t005264001.1	molecular_function	GO:0017168	5-oxoprolinase (ATP-hydrolyzing) activity	"Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate." [EC:3.5.2.9, RHEA:10348]	PANTHER
NV2t005265001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005265001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005265001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005265001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005265002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005265002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005265003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005265003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005267001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t005267001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t005269001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t005269001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t005270001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005270001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	PANTHER
NV2t005270001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	InterPro
NV2t005270002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005270002.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	PANTHER
NV2t005270002.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	InterPro
NV2t005270003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005270003.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	PANTHER
NV2t005271001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	OMA
NV2t005271001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t005271001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005271001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005272001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t005272001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t005273001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t005273001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t005273003.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t005273003.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t005276001.1	biological_process	GO:0000712	resolution of meiotic recombination intermediates	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]	OMA
NV2t005276001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t005276001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t005276001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	OMA
NV2t005276001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t005276001.1	cellular_component	GO:0071821	FANCM-MHF complex	"A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes." [GOC:mah, GOC:vw, PMID:20347428]	InterPro
NV2t005276001.1	cellular_component	GO:0071821	FANCM-MHF complex	"A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes." [GOC:mah, GOC:vw, PMID:20347428]	PANTHER
NV2t005276001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t005276001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t005276001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t005276001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t005277001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	InterPro
NV2t005277001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t005278001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t005278001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t005278001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t005278001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005278001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005278001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t005278001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	InterPro
NV2t005278001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	PANTHER
NV2t005278001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005280001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005280001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005280001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005281001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t005281001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t005281001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t005281001.1	molecular_function	GO:0042171	lysophosphatidic acid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]	PANTHER
NV2t005283001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t005283001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t005283001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t005283001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t005283001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t005283001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t005284001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t005284001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t005288001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005288001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005292001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t005293003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005295001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005295001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005295001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t005295001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005295001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t005295001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t005296001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	PANTHER
NV2t005298001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t005298001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005298001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005299001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005299001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005299001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t005299001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005299001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t005301001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	PANTHER
NV2t005305001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005306001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	InterPro
NV2t005306002.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	InterPro
NV2t005307001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005307001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t005307002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t005308001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005308001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005309001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005309002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005310001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005310001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t005310001.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	OMA
NV2t005310001.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t005310001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005310001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t005310001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t005310001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t005310001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t005310002.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005310002.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t005310002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t005310003.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005310003.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t005310003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t005312001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005312001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005315001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t005315001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t005315001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t005319001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005319001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t005319002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005319003.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005321001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005321001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t005325001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	OMA
NV2t005325001.1	biological_process	GO:0010457	centriole-centriole cohesion	"The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]	OMA
NV2t005325001.1	biological_process	GO:0032053	ciliary basal body organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124]	OMA
NV2t005325001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	InterPro
NV2t005325001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t005325001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t005325001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t005326001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005326001.1	molecular_function	GO:0008121	ubiquinol-cytochrome-c reductase activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [RHEA:11484]	InterPro
NV2t005326001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t005326001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t005326001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t005326001.1	molecular_function	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	"Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t005326001.1	molecular_function	GO:0022853	active monoatomic ion transmembrane transporter activity	"Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005326001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t005326001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t005326002.1	molecular_function	GO:0008121	ubiquinol-cytochrome-c reductase activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [RHEA:11484]	InterPro
NV2t005326002.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t005331001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	InterPro
NV2t005331001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t005331001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005334001.1	biological_process	GO:0006801	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl]	OMA
NV2t005334001.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t005334001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005334001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t005334001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005334001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t005334002.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t005334002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005335001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005335001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t005335002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005335002.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t005335003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005335003.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t005336001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t005336001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t005336001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t005336001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005336001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005336001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t005337001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t005337001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t005337001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005337001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t005337002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t005337002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005338001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t005338001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t005338001.1	biological_process	GO:0031338	regulation of vesicle fusion	"Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah]	OMA
NV2t005338001.1	biological_process	GO:0048729	tissue morphogenesis	"The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]	OMA
NV2t005338001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t005338001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t005338001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t005338001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t005338001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t005338001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005338001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t005339001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005339001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t005339001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t005339001.1	biological_process	GO:0030950	establishment or maintenance of actin cytoskeleton polarity	"Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah]	OMA
NV2t005339001.1	biological_process	GO:0032878	regulation of establishment or maintenance of cell polarity	"Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t005339001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t005339001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t005339001.1	biological_process	GO:0072697	protein localization to cell cortex	"A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah]	OMA
NV2t005339001.1	biological_process	GO:0072741	protein localization to cell division site	"A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division." [GOC:mah, PMID:19756689]	OMA
NV2t005339001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t005339001.1	cellular_component	GO:0005826	actomyosin contractile ring	"A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, GOC:vw, ISBN:0805319409, ISBN:0815316194, PMID:28914606]	OMA
NV2t005339001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t005339001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005339001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005339001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005340001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005340001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005340002.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005340002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005340003.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005340003.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005340003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005340003.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t005340004.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005340004.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005340005.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005340005.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005340006.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005343001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t005343001.1	biological_process	GO:0006801	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl]	OMA
NV2t005343001.1	biological_process	GO:0009891	positive regulation of biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	OMA
NV2t005343001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t005343001.1	biological_process	GO:0017004	cytochrome complex assembly	"The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah]	OMA
NV2t005343001.1	biological_process	GO:0043500	muscle adaptation	"A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]	OMA
NV2t005343001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t005343001.1	biological_process	GO:0050665	hydrogen peroxide biosynthetic process	"The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai]	OMA
NV2t005343001.1	biological_process	GO:0050766	positive regulation of phagocytosis	"Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]	OMA
NV2t005343001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t005343001.1	biological_process	GO:0062208	positive regulation of pattern recognition receptor signaling pathway	"Any process that decreases the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]	OMA
NV2t005343001.1	biological_process	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	OMA
NV2t005343001.1	biological_process	GO:1900426	positive regulation of defense response to bacterium	"Any process that activates or increases the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749]	OMA
NV2t005343001.1	biological_process	GO:1903426	regulation of reactive oxygen species biosynthetic process	"Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	OMA
NV2t005343001.1	biological_process	GO:2000379	positive regulation of reactive oxygen species metabolic process	"Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]	OMA
NV2t005343001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t005343001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t005343001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t005343001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t005343001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t005343001.1	molecular_function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	"Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195]	OMA
NV2t005343001.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	OMA
NV2t005343001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005343001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t005343001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t005343002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005344001.1	biological_process	GO:0071163	DNA replication preinitiation complex assembly	"The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins as part of initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity." [GOC:mah, PMID:28209641]	InterPro
NV2t005346001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005346001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005346001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005347001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t005347001.1	biological_process	GO:0032098	regulation of appetite	"Any process which modulates appetite, the desire or physical craving for food." [GOC:add]	OMA
NV2t005347001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005347001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t005347001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005352001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t005352001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005353001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t005353001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t005354001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005354001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005355001.1	cellular_component	GO:0016272	prefoldin complex	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]	InterPro
NV2t005355001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t005356001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t005359001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t005359001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t005359001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005359001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t005359001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t005359001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	PANTHER
NV2t005359001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t005360001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t005360001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t005360001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t005360001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t005360001.1	biological_process	GO:0043410	positive regulation of MAPK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]	OMA
NV2t005360001.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	OMA
NV2t005360001.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005360001.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	OMA
NV2t005360001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t005360001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t005360001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005360001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005360001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005360001.1	molecular_function	GO:0000182	rDNA binding	"Binding to a DNA sequence encoding a ribosomal RNA." [GOC:mah]	OMA
NV2t005360001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t005360001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t005360001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t005360001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005360001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005360001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005360001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005360001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t005362001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005362001.1	biological_process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]	OMA
NV2t005362001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t005362001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t005362001.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t005362001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t005363001.1	biological_process	GO:0007064	mitotic sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]	OMA
NV2t005363001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t005363001.1	cellular_component	GO:0031390	Ctf18 RFC-like complex	"A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842]	InterPro
NV2t005363001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t005364001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t005364001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t005364001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t005364001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t005364001.1	biological_process	GO:0071560	cellular response to transforming growth factor beta stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]	OMA
NV2t005364001.1	biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t005364001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t005364001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005364001.1	cellular_component	GO:0005902	microvillus	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]	OMA
NV2t005364001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t005364001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t005364001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005364001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t005366001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t005369001.1	molecular_function	GO:0031071	cysteine desulfurase activity	"Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]	PANTHER
NV2t005369002.1	molecular_function	GO:0031071	cysteine desulfurase activity	"Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]	PANTHER
NV2t005369003.1	molecular_function	GO:0031071	cysteine desulfurase activity	"Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]	PANTHER
NV2t005369004.1	molecular_function	GO:0031071	cysteine desulfurase activity	"Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]	PANTHER
NV2t005371001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005371001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005371001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005371002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005371002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005371003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005371003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005372001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t005372002.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t005373001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005373001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005373002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005373002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005376001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t005376001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	InterPro
NV2t005376001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	OMA
NV2t005376001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	PANTHER
NV2t005378001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t005378001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	InterPro
NV2t005378001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	OMA
NV2t005378001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	PANTHER
NV2t005379001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t005379001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t005379001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005379001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005379001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005379001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005379001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t005381001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t005381001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	InterPro
NV2t005381001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	OMA
NV2t005381001.1	biological_process	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	OMA
NV2t005381001.1	cellular_component	GO:0000145	exocyst	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]	OMA
NV2t005381001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t005383001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t005383001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t005383001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005383001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005384001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005384001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005385001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005386001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t005386001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t005386001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t005386002.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t005386002.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t005387001.1	biological_process	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	OMA
NV2t005387001.1	biological_process	GO:0006222	UMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732]	OMA
NV2t005387001.1	biological_process	GO:0009220	pyrimidine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t005387001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t005387001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005387001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t005387001.1	molecular_function	GO:0004152	dihydroorotate dehydrogenase activity	"Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [RHEA:18073]	OMA
NV2t005387001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t005389001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t005389001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t005390001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t005390001.1	biological_process	GO:0006265	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	InterPro
NV2t005390001.1	biological_process	GO:0006265	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	OMA
NV2t005390001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t005390001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t005390001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	PANTHER
NV2t005390001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t005390001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t005390001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005390001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005390001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t005390001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t005390001.1	molecular_function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	OMA
NV2t005394001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005394001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t005394001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005396001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t005396001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t005396001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t005396001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t005396001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t005397001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t005397001.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	PANTHER
NV2t005397001.1	biological_process	GO:0060326	cell chemotaxis	"The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]	OMA
NV2t005397001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t005397001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005397001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005397001.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	OMA
NV2t005397002.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	PANTHER
NV2t005397003.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	PANTHER
NV2t005397004.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	PANTHER
NV2t005397005.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	PANTHER
NV2t005398001.1	biological_process	GO:0006725	obsolete cellular aromatic compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732]	OMA
NV2t005398001.1	biological_process	GO:0006767	water-soluble vitamin metabolic process	"The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl]	OMA
NV2t005398001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	OMA
NV2t005398001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t005398001.1	biological_process	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	OMA
NV2t005398001.1	biological_process	GO:0034308	primary alcohol metabolic process	"The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]	OMA
NV2t005398001.1	biological_process	GO:0072527	pyrimidine-containing compound metabolic process	"The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t005398001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t005398001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t005398001.1	molecular_function	GO:0050333	thiamine triphosphate phosphatase activity	"Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate." [RHEA:11744]	InterPro
NV2t005398001.1	molecular_function	GO:0050333	thiamine triphosphate phosphatase activity	"Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate." [RHEA:11744]	PANTHER
NV2t005399001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t005399001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t005399001.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	PANTHER
NV2t005400001.1	biological_process	GO:0000212	meiotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t005400001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005400001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t005400001.1	biological_process	GO:0007100	mitotic centrosome separation	"Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]	OMA
NV2t005400001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t005400001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t005400001.1	biological_process	GO:0098813	nuclear chromosome segregation	"The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos]	OMA
NV2t005400001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005400001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t005400001.1	cellular_component	GO:0031616	spindle pole centrosome	"A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]	OMA
NV2t005400001.1	cellular_component	GO:0032133	chromosome passenger complex	"A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]	OMA
NV2t005400001.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	OMA
NV2t005400001.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	PANTHER
NV2t005400001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005400001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005400001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005400001.1	molecular_function	GO:0035174	obsolete histone serine kinase activity	"OBSOLETE. Catalysis of the transfer of a phosphate group to a serine residue of a histone." [GOC:bf]	OMA
NV2t005402001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t005404001.1	biological_process	GO:0043405	regulation of MAP kinase activity	"Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	PANTHER
NV2t005404002.1	biological_process	GO:0043405	regulation of MAP kinase activity	"Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	PANTHER
NV2t005405001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005405001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t005405001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t005405001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t005406001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005406001.1	molecular_function	GO:0008832	dGTPase activity	"Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate." [EC:3.1.5.1, RHEA:15193]	PANTHER
NV2t005409001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t005409001.1	biological_process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]	OMA
NV2t005409001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t005409001.1	biological_process	GO:0006195	purine nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005409001.1	biological_process	GO:0009144	purine nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005409001.1	biological_process	GO:0009151	purine deoxyribonucleotide metabolic process	"The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005409001.1	biological_process	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	OMA
NV2t005409001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t005409001.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t005409001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t005409001.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t005409001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t005409001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005409001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005409001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t005409001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t005409001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t005409001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	OMA
NV2t005409001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005409001.1	molecular_function	GO:0008832	dGTPase activity	"Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate." [EC:3.1.5.1, RHEA:15193]	PANTHER
NV2t005409001.1	molecular_function	GO:0019001	guanyl nucleotide binding	"Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t005409001.1	molecular_function	GO:0042578	phosphoric ester hydrolase activity	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]	OMA
NV2t005409001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t005409001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t005409001.1	molecular_function	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	OMA
NV2t005412001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t005416001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t005416001.1	molecular_function	GO:0047757	chondroitin-glucuronate 5-epimerase activity	"Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN]	PANTHER
NV2t005421001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t005423001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t005423001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t005423001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005424001.1	biological_process	GO:0006884	cell volume homeostasis	"Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t005424001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t005424001.1	biological_process	GO:0055080	monoatomic cation homeostasis	"Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah]	OMA
NV2t005424001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005424001.1	biological_process	GO:0071472	cellular response to salt stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]	OMA
NV2t005424001.1	biological_process	GO:0098659	inorganic cation import across plasma membrane	"The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t005424001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t005424001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t005424001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005424001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t005424001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t005424001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t005424001.1	molecular_function	GO:0015379	potassium:chloride symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.1.5]	OMA
NV2t005424001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t005424001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005425001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t005425001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t005425001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005426001.1	molecular_function	GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	"Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34]	PANTHER
NV2t005429001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005431001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t005431001.1	cellular_component	GO:0031501	mannosyltransferase complex	"A complex that posseses mannosyltransferase activity." [GOC:mah]	OMA
NV2t005431001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t005431001.1	cellular_component	GO:1990529	glycosylphosphatidylinositol-mannosyltransferase I complex	"A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M." [GOC:dph, GOC:rb, PMID:15635094]	PANTHER
NV2t005431001.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	OMA
NV2t005431001.1	molecular_function	GO:0051751	alpha-1,4-mannosyltransferase activity	"Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage." [PMID:15772281]	InterPro
NV2t005432001.1	biological_process	GO:0046939	obsolete nucleotide phosphorylation	"OBSOLETE. The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]	PANTHER
NV2t005432001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005433001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t005433001.1	biological_process	GO:0046939	obsolete nucleotide phosphorylation	"OBSOLETE. The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]	OMA
NV2t005433001.1	biological_process	GO:0046939	obsolete nucleotide phosphorylation	"OBSOLETE. The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]	PANTHER
NV2t005433001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t005433001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t005433001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t005433001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	OMA
NV2t005433001.1	molecular_function	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	"Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [RHEA:15669]	InterPro
NV2t005433002.1	biological_process	GO:0046939	obsolete nucleotide phosphorylation	"OBSOLETE. The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]	PANTHER
NV2t005434001.1	biological_process	GO:0006812	monoatomic cation transport	"The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t005434001.1	biological_process	GO:0006821	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t005434001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005434001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t005434001.1	molecular_function	GO:0005227	calcium-activated cation channel activity	"Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	OMA
NV2t005436001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t005436001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005436001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005436001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t005439003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005443001.1	biological_process	GO:0000056	ribosomal small subunit export from nucleus	"The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t005443001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t005443001.1	biological_process	GO:0036260	RNA capping	"The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673]	OMA
NV2t005443001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t005443001.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	OMA
NV2t005443001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005443001.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	PANTHER
NV2t005443001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t005443001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005443001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t005444001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t005444001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005444001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005444001.1	molecular_function	GO:0017128	phospholipid scramblase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]	OMA
NV2t005445001.1	biological_process	GO:0006066	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732]	OMA
NV2t005445001.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t005445001.1	biological_process	GO:0042180	cellular ketone metabolic process	"The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]	OMA
NV2t005445001.1	biological_process	GO:0042574	retinal metabolic process	"The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [ISBN:0198506732]	OMA
NV2t005445001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t005445001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t005445001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t005445001.1	molecular_function	GO:0004090	carbonyl reductase (NADPH) activity	"Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]	OMA
NV2t005445001.1	molecular_function	GO:0004090	carbonyl reductase (NADPH) activity	"Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]	PANTHER
NV2t005445001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t005445001.1	molecular_function	GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71]	OMA
NV2t005445001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t005446001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005446001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t005446001.1	biological_process	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	"The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]	OMA
NV2t005446001.1	biological_process	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	"The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]	PANTHER
NV2t005446001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005446001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005446001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005446001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t005446001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t005446001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005446001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005449001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t005449001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005452001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	InterPro
NV2t005452001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t005452001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005452002.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	InterPro
NV2t005452003.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	InterPro
NV2t005452004.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	InterPro
NV2t005452005.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	InterPro
NV2t005452005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005452006.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	InterPro
NV2t005452006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005453001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t005453001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t005453001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005455001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t005455001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t005456001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t005456001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t005457001.1	biological_process	GO:0006168	adenine salvage	"Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl]	InterPro
NV2t005457001.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	OMA
NV2t005457001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005457001.1	biological_process	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005457001.1	biological_process	GO:0044209	AMP salvage	"The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350]	PANTHER
NV2t005457001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005457001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t005457001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t005457001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t005457001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t005458001.1	biological_process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	"An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]	OMA
NV2t005458001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t005458001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t005458001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t005458001.1	biological_process	GO:0050795	regulation of behavior	"Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr]	OMA
NV2t005458001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005458001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005458001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t005458001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t005458001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t005458001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005458001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t005458001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t005458001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t005459001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005459001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t005459001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t005459001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005459001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005461001.1	biological_process	GO:0006750	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]	InterPro
NV2t005461001.1	biological_process	GO:0006750	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]	OMA
NV2t005461001.1	biological_process	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	OMA
NV2t005461001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005461001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t005461001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005461001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005461001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	InterPro
NV2t005461001.1	molecular_function	GO:0016881	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	OMA
NV2t005461001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t005461001.1	molecular_function	GO:0043295	glutathione binding	"Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]	OMA
NV2t005461001.1	molecular_function	GO:0043295	glutathione binding	"Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]	PANTHER
NV2t005461002.1	biological_process	GO:0006750	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]	InterPro
NV2t005461002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005461002.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	InterPro
NV2t005461002.1	molecular_function	GO:0043295	glutathione binding	"Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]	PANTHER
NV2t005462001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005462001.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	PANTHER
NV2t005462001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005462001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005462002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005463001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005463001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t005463001.1	biological_process	GO:0006990	obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	"OBSOLETE. The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763]	PANTHER
NV2t005463001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005463001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t005463001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t005463001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005463002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005463002.1	biological_process	GO:0006990	obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	"OBSOLETE. The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763]	PANTHER
NV2t005463003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005463003.1	biological_process	GO:0006990	obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	"OBSOLETE. The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763]	PANTHER
NV2t005464001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005464001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t005464001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t005465001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005468001.1	biological_process	GO:0042984	regulation of amyloid precursor protein biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators]	PANTHER
NV2t005468002.1	biological_process	GO:0042984	regulation of amyloid precursor protein biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators]	PANTHER
NV2t005468003.1	biological_process	GO:0042984	regulation of amyloid precursor protein biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators]	PANTHER
NV2t005468004.1	biological_process	GO:0042984	regulation of amyloid precursor protein biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators]	PANTHER
NV2t005468005.1	biological_process	GO:0042984	regulation of amyloid precursor protein biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators]	PANTHER
NV2t005468005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005468005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005469001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t005469001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t005469001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005469001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t005469001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t005469001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t005469001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t005469001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t005471001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	InterPro
NV2t005471001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t005471001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t005471001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005471001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t005471001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005471001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t005471001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t005471001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t005471001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t005471001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t005471002.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	InterPro
NV2t005471002.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t005475001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005475002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005477001.1	biological_process	GO:0035249	synaptic transmission, glutamatergic	"The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]	OMA
NV2t005477001.1	biological_process	GO:0050804	modulation of chemical synaptic transmission	"Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]	OMA
NV2t005477001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005477001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t005477001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t005477001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t005477001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t005478001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005478002.1	biological_process	GO:0002949	tRNA threonylcarbamoyladenosine modification	"The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]	InterPro
NV2t005478002.1	biological_process	GO:0002949	tRNA threonylcarbamoyladenosine modification	"The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]	OMA
NV2t005478002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005478002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005478002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005478002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005478002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t005478003.1	biological_process	GO:0002949	tRNA threonylcarbamoyladenosine modification	"The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]	InterPro
NV2t005478003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005479001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t005481001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005481001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005481001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t005481001.1	molecular_function	GO:0140603	obsolete ATP hydrolysis activity	"OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [GOC:curators]	PANTHER
NV2t005482001.1	biological_process	GO:0000002	mitochondrial genome maintenance	"The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]	OMA
NV2t005482001.1	biological_process	GO:0000725	recombinational repair	"A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh]	OMA
NV2t005482001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t005482001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t005482001.1	cellular_component	GO:0000262	mitochondrial chromosome	"A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah]	OMA
NV2t005482001.1	cellular_component	GO:0042645	mitochondrial nucleoid	"The region of a mitochondrion to which the DNA is confined." [GOC:jl]	PANTHER
NV2t005482001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t005485001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005485001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005485001.1	molecular_function	GO:0047865	dimethylglycine dehydrogenase activity	"Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.4, RHEA:52856]	PANTHER
NV2t005490001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t005490001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005493001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t005495001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t005495001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005499001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005499001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t005499001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005499001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005500004.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t005500004.1	biological_process	GO:0009409	response to cold	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]	OMA
NV2t005500004.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t005500004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005500004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t005500005.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t005500006.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t005500007.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t005501001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t005501001.1	biological_process	GO:0036260	RNA capping	"The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673]	OMA
NV2t005501001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t005501001.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	OMA
NV2t005501001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005501001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t005501001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t005501001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005501001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	OMA
NV2t005501001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	PANTHER
NV2t005503001.1	biological_process	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	"The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai]	OMA
NV2t005503001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t005503001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t005503001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t005503001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	OMA
NV2t005503001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t005503001.1	molecular_function	GO:0034483	heparan sulfate sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate." [GOC:mah]	OMA
NV2t005504001.1	biological_process	GO:0006448	regulation of translational elongation	"Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]	OMA
NV2t005504001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t005504001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t005504001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t005504001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t005504001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005504001.1	cellular_component	GO:0048500	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	InterPro
NV2t005504001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t005504001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t005513001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t005513001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005517001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t005517002.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t005518001.1	biological_process	GO:0002028	regulation of sodium ion transport	"Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]	OMA
NV2t005518001.1	biological_process	GO:0002028	regulation of sodium ion transport	"Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]	PANTHER
NV2t005518002.1	biological_process	GO:0002028	regulation of sodium ion transport	"Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]	PANTHER
NV2t005519003.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t005519003.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t005519003.1	biological_process	GO:0032780	negative regulation of ATP-dependent activity	"Any process that stops or reduces the rate of an ATP-dependent activity." [GOC:mah]	OMA
NV2t005519003.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t005519003.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t005519003.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t005519003.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t005519003.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t005519003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t005519003.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t005519003.1	molecular_function	GO:0042030	ATPase inhibitor activity	"Binds to and stops, prevents or reduces an ATP hydrolysis activity." [GOC:jl]	InterPro
NV2t005519003.1	molecular_function	GO:0060590	ATPase regulator activity	"Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]	OMA
NV2t005519003.1	molecular_function	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t005520001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	InterPro
NV2t005522001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t005523001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t005523001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t005523001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005523001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005524005.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524006.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524007.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524008.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524009.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524010.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524011.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524012.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524013.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524013.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005524014.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t005524014.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005527001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t005527001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t005527001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	OMA
NV2t005527001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005527001.1	molecular_function	GO:0008195	phosphatidate phosphatase activity	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [GOC:pr, PMID:25814022, RHEA:27429]	OMA
NV2t005529001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005531001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t005531001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t005531001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t005532001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005532002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005532003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005533001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005536001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t005536001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005541001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t005541001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t005541001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t005541001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t005541001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t005541001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t005543001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t005543001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	OMA
NV2t005543001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t005550001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005552001.1	cellular_component	GO:0070390	transcription export complex 2	"A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829]	PANTHER
NV2t005552001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005567001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t005572001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005572001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005576001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	OMA
NV2t005576001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005576001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005576002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005578001.1	biological_process	GO:0006107	oxaloacetate metabolic process	"The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732]	PANTHER
NV2t005578001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t005578001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t005580001.1	biological_process	GO:0072530	purine-containing compound transmembrane transport	"The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t005580001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t005580001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t005580001.1	molecular_function	GO:0000295	adenine nucleotide transmembrane transporter activity	"Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other." [PMID:11566870]	OMA
NV2t005580001.1	molecular_function	GO:0051724	NAD transmembrane transporter activity	"Enables the transfer of NAD from one side of a membrane to the other." [GOC:TermGenie]	PANTHER
NV2t005581001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005581001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t005581001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t005582001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t005582001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t005582001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t005582001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005582001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005583002.1	biological_process	GO:0051493	regulation of cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	PANTHER
NV2t005583002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005583003.1	biological_process	GO:0051493	regulation of cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]	PANTHER
NV2t005583003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005584001.1	biological_process	GO:0006817	phosphate ion transport	"The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t005584001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	PANTHER
NV2t005584001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005584001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005584001.1	molecular_function	GO:0005315	phosphate transmembrane transporter activity	"Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]	OMA
NV2t005590001.1	biological_process	GO:0006817	phosphate ion transport	"The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t005590001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	PANTHER
NV2t005590001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005590001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005590001.1	molecular_function	GO:0005315	phosphate transmembrane transporter activity	"Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]	OMA
NV2t005593001.1	biological_process	GO:0006817	phosphate ion transport	"The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t005593001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	PANTHER
NV2t005593001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005593001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005593001.1	molecular_function	GO:0005315	phosphate transmembrane transporter activity	"Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport]	OMA
NV2t005595001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005595001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t005595001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t005595001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t005595001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t005595001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005614001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t005614001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005614001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t005617001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t005617001.1	biological_process	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	"The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb]	PANTHER
NV2t005624001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t005624001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t005624001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005624001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005624002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t005624002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005624003.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t005624003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005628001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005628002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005628003.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	InterPro
NV2t005628003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t005628003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005628003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005628003.1	molecular_function	GO:0004467	long-chain fatty acid-CoA ligase activity	"Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [RHEA:15421]	OMA
NV2t005628004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005629001.1	biological_process	GO:0000038	very long-chain fatty acid metabolic process	"The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:hjd]	OMA
NV2t005629001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	InterPro
NV2t005629001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t005629001.1	biological_process	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t005629001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t005629001.1	biological_process	GO:0032370	positive regulation of lipid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t005629001.1	biological_process	GO:0032892	positive regulation of organic acid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t005629001.1	biological_process	GO:0034764	positive regulation of transmembrane transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]	OMA
NV2t005629001.1	biological_process	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]	OMA
NV2t005629001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t005629001.1	biological_process	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	OMA
NV2t005629001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t005629001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t005629001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005629001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005629001.1	molecular_function	GO:0004467	long-chain fatty acid-CoA ligase activity	"Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [RHEA:15421]	OMA
NV2t005629002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005630001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t005630001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005630001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005634001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t005634001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005634001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005653001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005654001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t005658001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t005658001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t005658001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t005658001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005658001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005658001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t005659001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005659001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005659001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005659002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005659002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005660001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t005660001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t005660001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005661001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t005661001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t005661001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t005661001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t005661001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t005662001.1	biological_process	GO:0006820	monoatomic anion transport	"The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t005662001.1	biological_process	GO:0046942	carboxylic acid transport	"The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]	OMA
NV2t005662001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005662001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t005662001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005662001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005662001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t005662001.1	molecular_function	GO:1901505	carbohydrate derivative transmembrane transporter activity	"Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t005663001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t005663001.1	biological_process	GO:1900542	regulation of purine nucleotide metabolic process	"Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie]	OMA
NV2t005663001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t005663001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005663001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t005663001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t005663001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t005663001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t005663001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t005663001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t005663001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t005663001.1	molecular_function	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	OMA
NV2t005663001.1	molecular_function	GO:0140030	modification-dependent protein binding	"Binding to a protein upon post-translation modification of the target protein." [PMID:26060076]	OMA
NV2t005664001.1	biological_process	GO:0006353	DNA-templated transcription termination	"The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template." [GOC:txnOH, PMID:15020047, PMID:18280161, PMID:30978344]	OMA
NV2t005664001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005664001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	OMA
NV2t005664001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005664001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t005666001.1	molecular_function	GO:0043548	phosphatidylinositol 3-kinase binding	"Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069]	PANTHER
NV2t005666002.1	molecular_function	GO:0043548	phosphatidylinositol 3-kinase binding	"Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069]	PANTHER
NV2t005667001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t005667001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t005667001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005669001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t005669001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	PANTHER
NV2t005669001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t005669001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t005669001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t005669001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t005669001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t005669001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t005669001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t005669001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t005685001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t005685001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005686001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005686002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005686003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005686004.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005687001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t005688001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t005688001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005688001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005688002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t005688002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005692001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t005693001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005693001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005693001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t005693001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005693001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t005695001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005698001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t005698001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005698001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t005698001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t005698001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005700001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t005700002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t005700002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t005701001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005701001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t005701002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005701002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t005701002.1	biological_process	GO:0007254	JNK cascade	"A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:11790549, PMID:20811974, PMID:23125017]	OMA
NV2t005701002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t005701002.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t005701002.1	molecular_function	GO:0004707	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	OMA
NV2t005701002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005701003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005701003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t005701004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005701004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t005701005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005701005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t005701006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005701006.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t005702001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005702001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t005702001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t005704001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005705001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005705002.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005706001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t005706001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t005706002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005706002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t005706002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t005706002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t005707001.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t005707001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005707001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005707001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005707002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t005707002.1	biological_process	GO:0009889	regulation of biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	OMA
NV2t005707002.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t005707002.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t005707002.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t005707002.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t005707002.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t005707002.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t005707002.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t005707002.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	OMA
NV2t005707002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t005707002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005707002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005707002.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t005707002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005707002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005707002.1	molecular_function	GO:0036002	pre-mRNA binding	"Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]	OMA
NV2t005707002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t005708001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005708001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005708002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005708002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005708003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005708003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005708004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005708004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005709001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005709004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005709008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709009.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709010.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709011.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709012.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709013.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709014.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709015.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709016.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709017.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709018.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005709019.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005710001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005710001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005710001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005710002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005710002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005710002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005710003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005710003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005710003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005710004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005710005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005710005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005710005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005711001.1	molecular_function	GO:0032183	SUMO binding	"Binding to the small ubiquitin-like protein SUMO." [GOC:mah]	InterPro
NV2t005712001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t005712001.1	biological_process	GO:0051168	nuclear export	"The directed movement of substances out of the nucleus." [GOC:ai]	InterPro
NV2t005712001.1	biological_process	GO:0051168	nuclear export	"The directed movement of substances out of the nucleus." [GOC:ai]	OMA
NV2t005712001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t005713001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005713001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t005713001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005713001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t005713001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t005713001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005713001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005713001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005714001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	InterPro
NV2t005714001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	OMA
NV2t005714001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t005714001.1	cellular_component	GO:1902555	endoribonuclease complex	"A protein complex which is capable of endoribonuclease activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t005714001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005714001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t005714001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t005714001.1	molecular_function	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah]	OMA
NV2t005714001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t005714002.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	InterPro
NV2t005714002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005715001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t005716001.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t005716001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005716001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005716002.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t005716002.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t005716002.1	biological_process	GO:0045880	positive regulation of smoothened signaling pathway	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t005716002.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t005716002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005716002.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t005716002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005716002.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t005716002.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t005716002.1	molecular_function	GO:0005113	patched binding	"Binding to a patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473]	OMA
NV2t005716002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005717001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t005723001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t005723002.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t005723002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t005723002.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t005723002.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t005726001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t005726001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t005727001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005727001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t005728001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t005728001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t005728001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005729001.1	biological_process	GO:0006370	7-methylguanosine mRNA capping	"The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:mah, PMID:9266685]	InterPro
NV2t005729001.1	biological_process	GO:0006370	7-methylguanosine mRNA capping	"The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:mah, PMID:9266685]	PANTHER
NV2t005729001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t005729001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t005729001.1	molecular_function	GO:0140818	mRNA 5'-triphosphate monophosphatase activity	"A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate." [PMID:9473487]	InterPro
NV2t005735001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t005735001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t005735001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	OMA
NV2t005735001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t005735001.1	biological_process	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t005735001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t005735001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t005735001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005735001.1	molecular_function	GO:0030295	protein kinase activator activity	"Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t005735001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t005735001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	PANTHER
NV2t005735002.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t005735002.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	PANTHER
NV2t005735003.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t005735003.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	PANTHER
NV2t005737001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t005739001.1	biological_process	GO:0045048	protein insertion into ER membrane	"The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]	PANTHER
NV2t005739001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005740002.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t005740004.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t005740006.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005740006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005740006.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t005740007.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t005740008.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t005741001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005741001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005741001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t005741002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005741002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t005741003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005741003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t005741004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005741004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t005747001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t005747001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t005747001.1	cellular_component	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	OMA
NV2t005747001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005747001.1	molecular_function	GO:0031681	G-protein beta-subunit binding	"Binding to a G-protein beta subunit." [GOC:mah]	InterPro
NV2t005747001.1	molecular_function	GO:0031681	G-protein beta-subunit binding	"Binding to a G-protein beta subunit." [GOC:mah]	PANTHER
NV2t005750001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005750001.1	molecular_function	GO:1990247	N6-methyladenosine-containing RNA reader activity	"A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]	PANTHER
NV2t005752001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t005752001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t005752001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t005752001.1	biological_process	GO:0007033	vacuole organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]	OMA
NV2t005752001.1	biological_process	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	OMA
NV2t005752001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t005752001.1	biological_process	GO:0048284	organelle fusion	"The creation of a single organelle from two or more organelles." [GOC:jid]	OMA
NV2t005752001.1	biological_process	GO:0048284	organelle fusion	"The creation of a single organelle from two or more organelles." [GOC:jid]	PANTHER
NV2t005752001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t005752001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t005752001.1	cellular_component	GO:0030897	HOPS complex	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]	OMA
NV2t005752001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005752001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t005753001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t005753001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005753001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t005753001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t005753001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t005759002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t005759002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005759002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005761001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005762001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005762001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005765001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005765001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t005765001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005766001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005766001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005768001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005768001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005768001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t005768001.1	molecular_function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	OMA
NV2t005770001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t005770001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t005770001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t005770001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t005770001.1	cellular_component	GO:0030176	obsolete integral component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t005770001.1	cellular_component	GO:1990351	transporter complex	"A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]	OMA
NV2t005770001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005775001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t005775001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t005775001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t005775001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005775001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t005775001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t005775001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005777001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005777002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005778001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t005778001.1	biological_process	GO:0006636	unsaturated fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]	OMA
NV2t005778001.1	biological_process	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t005778001.1	biological_process	GO:0033993	response to lipid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]	OMA
NV2t005778001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t005778001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t005778001.1	biological_process	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	OMA
NV2t005778001.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t005778001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t005778001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005778001.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	InterPro
NV2t005778001.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	OMA
NV2t005778002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t005778002.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	InterPro
NV2t005779001.1	biological_process	GO:0080111	DNA demethylation	"The removal of a methyl group from one or more nucleotides within an DNA molecule." [PMID:17208187]	PANTHER
NV2t005779001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005779002.1	biological_process	GO:0080111	DNA demethylation	"The removal of a methyl group from one or more nucleotides within an DNA molecule." [PMID:17208187]	PANTHER
NV2t005779002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005783001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	PANTHER
NV2t005785001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005785001.1	molecular_function	GO:0032934	sterol binding	"Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah]	PANTHER
NV2t005786001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t005786001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t005786001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005786001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t005787001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005787001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005787001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005787001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005789001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005791001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005797001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t005797001.1	biological_process	GO:0019321	pentose metabolic process	"The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t005797001.1	molecular_function	GO:0004090	carbonyl reductase (NADPH) activity	"Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]	OMA
NV2t005797001.1	molecular_function	GO:0050038	L-xylulose reductase (NADPH) activity	"Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH." [EC:1.1.1.10, RHEA:17025]	PANTHER
NV2t005797002.1	molecular_function	GO:0050038	L-xylulose reductase (NADPH) activity	"Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH." [EC:1.1.1.10, RHEA:17025]	PANTHER
NV2t005798001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t005798001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t005798001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t005798001.1	molecular_function	GO:0004563	beta-N-acetylhexosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]	OMA
NV2t005798001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005798001.1	molecular_function	GO:0030247	polysaccharide binding	"Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]	InterPro
NV2t005799001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005799001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t005799001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005799001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005799001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005799001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005801001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005801001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t005801001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005801001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005801001.1	molecular_function	GO:0008514	organic anion transmembrane transporter activity	"Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t005801001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005801001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005801001.1	molecular_function	GO:0090482	vitamin transmembrane transporter activity	"Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb]	OMA
NV2t005802001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005803001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t005803001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t005803001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t005803001.1	biological_process	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t005803001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t005803001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t005803001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t005803001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t005803001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t005803001.1	biological_process	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	OMA
NV2t005803001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t005803001.1	biological_process	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t005803001.1	biological_process	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t005803001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005803001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t005803001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t005803001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	OMA
NV2t005803001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t005803001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t005804001.1	biological_process	GO:0034613	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t005805001.1	biological_process	GO:0034613	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t005806001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005806001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t005806001.1	biological_process	GO:0034613	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t005806001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005807001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005807001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t005808001.1	molecular_function	GO:0004045	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	InterPro
NV2t005808002.1	molecular_function	GO:0004045	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	InterPro
NV2t005808002.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t005808002.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t005808003.1	molecular_function	GO:0004045	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	InterPro
NV2t005809001.1	biological_process	GO:0034613	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t005809002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005809002.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t005809002.1	biological_process	GO:0034613	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t005809002.1	biological_process	GO:0045664	regulation of neuron differentiation	"Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]	OMA
NV2t005809002.1	biological_process	GO:0048167	regulation of synaptic plasticity	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]	OMA
NV2t005809002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005809002.1	molecular_function	GO:0005080	protein kinase C binding	"Binding to protein kinase C." [GOC:jl]	OMA
NV2t005809002.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t005809002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t005809003.1	biological_process	GO:0034613	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t005814001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t005814001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005816001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t005816001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t005816001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005816001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005817001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t005817001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t005817001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005817001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005818001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t005818001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005818001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t005818002.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t005818002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005819001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t005819001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t005819001.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t005819001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t005819002.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t005819003.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t005819004.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t005819005.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t005819006.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t005819007.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t005820001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t005820001.1	biological_process	GO:0061462	protein localization to lysosome	"A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]	OMA
NV2t005820001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t005820001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t005820001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005820002.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t005822001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t005824001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t005824001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t005824001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t005824001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t005824001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t005827001.1	biological_process	GO:0050806	positive regulation of synaptic transmission	"Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]	PANTHER
NV2t005827002.1	biological_process	GO:0050806	positive regulation of synaptic transmission	"Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]	PANTHER
NV2t005827003.1	biological_process	GO:2000300	regulation of synaptic vesicle exocytosis	"Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]	PANTHER
NV2t005827003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005827003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t005827004.1	biological_process	GO:0050806	positive regulation of synaptic transmission	"Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]	PANTHER
NV2t005827004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005827004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005827005.1	biological_process	GO:0050806	positive regulation of synaptic transmission	"Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]	PANTHER
NV2t005827005.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t005831001.1	biological_process	GO:0006171	cAMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]	InterPro
NV2t005831001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t005831001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t005831001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005831001.1	biological_process	GO:0009190	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005831001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t005831001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t005831001.1	biological_process	GO:0046058	cAMP metabolic process	"The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators]	OMA
NV2t005831001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005831001.1	molecular_function	GO:0004016	adenylate cyclase activity	"Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]	OMA
NV2t005833001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005835001.1	cellular_component	GO:0090730	Las1 complex	"A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448)." [GOC:vw, PMID:26638174]	InterPro
NV2t005836001.1	biological_process	GO:0006936	muscle contraction	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]	OMA
NV2t005836001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t005836001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t005836001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t005836001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t005837001.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	PANTHER
NV2t005837001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005837002.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	PANTHER
NV2t005837002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005837003.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	PANTHER
NV2t005837003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005837004.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	PANTHER
NV2t005837004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005837005.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	PANTHER
NV2t005837005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005837006.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	PANTHER
NV2t005837006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005837007.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	PANTHER
NV2t005837007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005837008.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	PANTHER
NV2t005837008.1	biological_process	GO:0035196	miRNA processing	"A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604]	OMA
NV2t005837008.1	biological_process	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	OMA
NV2t005837008.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005837008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005837008.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t005839001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t005839001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t005841001.1	cellular_component	GO:1905202	methylcrotonoyl-CoA carboxylase complex	"A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity." [GO_REF:0000088, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22158123]	PANTHER
NV2t005841001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	InterPro
NV2t005841002.1	biological_process	GO:0006552	L-leucine catabolic process	"The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]	OMA
NV2t005841002.1	biological_process	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005841002.1	biological_process	GO:0033875	ribonucleoside bisphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t005841002.1	biological_process	GO:0034032	purine nucleoside bisphosphate metabolic process	"The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t005841002.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t005841002.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t005841002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t005841002.1	cellular_component	GO:1905202	methylcrotonoyl-CoA carboxylase complex	"A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity." [GO_REF:0000088, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22158123]	PANTHER
NV2t005841002.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	InterPro
NV2t005841002.1	molecular_function	GO:0016885	ligase activity, forming carbon-carbon bonds	"Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-, GOC:jl, GOC:mah]	OMA
NV2t005842001.1	biological_process	GO:0048208	COPII vesicle coating	"The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t005842001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005842002.1	biological_process	GO:0048208	COPII vesicle coating	"The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t005842002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005842003.1	biological_process	GO:0048208	COPII vesicle coating	"The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t005842003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005842004.1	biological_process	GO:0048208	COPII vesicle coating	"The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t005842004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005842004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005843001.1	cellular_component	GO:0034719	SMN-Sm protein complex	"A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408]	InterPro
NV2t005843001.1	cellular_component	GO:0034719	SMN-Sm protein complex	"A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408]	OMA
NV2t005843001.1	cellular_component	GO:0120114	Sm-like protein family complex	"A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles." [GOC:bhm, GOC:krc, PMID:19121818, PMID:27627834]	PANTHER
NV2t005845001.1	biological_process	GO:0097428	protein maturation by iron-sulfur cluster transfer	"The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]	PANTHER
NV2t005845001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t005846001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005846001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005847001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005847001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t005847001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005847001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t005847001.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t005847001.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	InterPro
NV2t005847001.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	OMA
NV2t005847001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t005847001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t005847001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t005847001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005849001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t005849001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t005849001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005849001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005849001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t005850001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t005850001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005852001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005852001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t005852001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005852002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t005852003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t005852004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005852004.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t005852004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005853001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t005853001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005853001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005853001.1	molecular_function	GO:0008417	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t005853001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t005855001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t005855001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t005855001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t005855001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t005855001.1	biological_process	GO:0043405	regulation of MAP kinase activity	"Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t005855001.1	biological_process	GO:0043405	regulation of MAP kinase activity	"Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	PANTHER
NV2t005855001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t005855001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005855001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t005855001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t005855001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t005855001.1	molecular_function	GO:0031434	mitogen-activated protein kinase kinase binding	"Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase." [GOC:mah]	OMA
NV2t005855001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t005855001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t005859001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t005862001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t005862001.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t005862001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005862001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005862001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t005862001.1	molecular_function	GO:0030731	guanidinoacetate N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H+." [EC:2.1.1.2, RHEA:10656]	PANTHER
NV2t005863001.1	biological_process	GO:0009435	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	InterPro
NV2t005863001.1	biological_process	GO:0034355	NAD salvage	"Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681, PMID:27374990]	PANTHER
NV2t005864001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005864001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t005864001.1	biological_process	GO:0009435	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	InterPro
NV2t005864001.1	biological_process	GO:0019359	nicotinamide nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]	OMA
NV2t005864001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t005864001.1	biological_process	GO:0034355	NAD salvage	"Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681, PMID:27374990]	PANTHER
NV2t005864001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005864001.1	molecular_function	GO:0004516	nicotinate phosphoribosyltransferase activity	"Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate." [PMID:7503993]	InterPro
NV2t005864001.1	molecular_function	GO:0016879	ligase activity, forming carbon-nitrogen bonds	"Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah]	OMA
NV2t005865001.1	biological_process	GO:0006552	L-leucine catabolic process	"The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]	OMA
NV2t005865001.1	biological_process	GO:0046951	ketone body biosynthetic process	"The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732]	OMA
NV2t005865001.1	biological_process	GO:0046951	ketone body biosynthetic process	"The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732]	PANTHER
NV2t005865001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t005865001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t005865001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t005867001.1	biological_process	GO:0006884	cell volume homeostasis	"Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t005867001.1	biological_process	GO:0055080	monoatomic cation homeostasis	"Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah]	OMA
NV2t005867001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005867001.1	biological_process	GO:0098659	inorganic cation import across plasma membrane	"The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t005867001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t005867001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t005867001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005867001.1	molecular_function	GO:0015379	potassium:chloride symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.1.5]	OMA
NV2t005870001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t005870001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t005870001.1	biological_process	GO:0031054	pre-miRNA processing	"A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]	OMA
NV2t005870001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t005870001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t005870001.1	biological_process	GO:0070922	RISC complex assembly	"The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA." [PMID:14512631, PMID:14744438, PMID:19239886, PMID:22233755, PMID:27184117]	OMA
NV2t005870001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t005870001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005870001.1	cellular_component	GO:0016442	RISC complex	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]	OMA
NV2t005870001.1	cellular_component	GO:0070578	RISC-loading complex	"A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]	OMA
NV2t005870001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005870001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t005870001.1	molecular_function	GO:0003727	single-stranded RNA binding	"Binding to single-stranded RNA." [GOC:jl]	OMA
NV2t005870001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005870001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t005870001.1	molecular_function	GO:0035198	miRNA binding	"Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]	OMA
NV2t005870001.1	molecular_function	GO:0035198	miRNA binding	"Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]	PANTHER
NV2t005870001.1	molecular_function	GO:0070551	endoribonuclease activity, cleaving siRNA-paired mRNA	"Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters." [GOC:mah, PMID:15105377]	OMA
NV2t005870001.1	molecular_function	GO:0090624	endoribonuclease activity, cleaving miRNA-paired mRNA	"Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970, PMID:19239888]	OMA
NV2t005873001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t005876001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005876001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t005879001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t005879001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t005879001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t005879001.1	molecular_function	GO:0004563	beta-N-acetylhexosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]	OMA
NV2t005879001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t005879001.1	molecular_function	GO:0030247	polysaccharide binding	"Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]	InterPro
NV2t005879001.1	molecular_function	GO:0030247	polysaccharide binding	"Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]	OMA
NV2t005884001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t005884001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005884001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t005884001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005884001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t005886001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t005886001.1	cellular_component	GO:0031262	Ndc80 complex	"An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis." [GOC:vw, PMID:28502666, PMID:34810257]	OMA
NV2t005886001.1	cellular_component	GO:0031262	Ndc80 complex	"An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis." [GOC:vw, PMID:28502666, PMID:34810257]	PANTHER
NV2t005886001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t005887001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t005887001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t005887001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005887002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005887003.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t005887003.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t005887003.1	biological_process	GO:0043549	regulation of kinase activity	"Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf]	OMA
NV2t005887003.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t005887003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005887003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t005887003.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t005887003.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t005887003.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t005887003.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t005887003.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t005887003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005887003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t005887003.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t005887004.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t005887004.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t005887004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005887005.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t005887005.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t005887005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005887006.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t005890001.1	biological_process	GO:0001881	receptor recycling	"The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph]	OMA
NV2t005890001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t005890001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t005890001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t005890001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t005890001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t005890001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t005891001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005891001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t005891001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t005891001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t005892001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t005892002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t005894001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t005894001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005894001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005895001.1	biological_process	GO:0018022	peptidyl-lysine methylation	"The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]	OMA
NV2t005895001.1	biological_process	GO:0018023	peptidyl-lysine trimethylation	"The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074]	InterPro
NV2t005895001.1	biological_process	GO:0018026	peptidyl-lysine monomethylation	"The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]	PANTHER
NV2t005895001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005895001.1	molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]	OMA
NV2t005897001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t005897001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005899001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005899003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t005899003.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t005899003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t005899003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899003.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t005899003.1	molecular_function	GO:0008143	poly(A) binding	"Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]	OMA
NV2t005899003.1	molecular_function	GO:0008266	poly(U) RNA binding	"Binding to a sequence of uracil residues in an RNA molecule." [GOC:mah]	OMA
NV2t005899004.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899005.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899006.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899007.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899008.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899008.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899009.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899009.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899009.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899010.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899010.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899010.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899011.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899011.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899011.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899012.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899012.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899012.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899013.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899013.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899013.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899014.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899014.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899014.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899015.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899015.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899015.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899016.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899016.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899016.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899017.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899017.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899017.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899018.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899018.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899018.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899019.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899019.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899019.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899020.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899020.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899020.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899021.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899021.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899021.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t005899022.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899022.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899022.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899023.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899023.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899023.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005899024.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005899024.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005899024.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005904001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t005905001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	OMA
NV2t005905001.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	OMA
NV2t005905001.1	biological_process	GO:0070897	transcription preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]	OMA
NV2t005905001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t005905001.1	molecular_function	GO:0001046	core promoter sequence-specific DNA binding	"Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH]	OMA
NV2t005905001.1	molecular_function	GO:0001163	RNA polymerase I transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH]	OMA
NV2t005905001.1	molecular_function	GO:0140223	general transcription initiation factor activity	"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]	OMA
NV2t005906001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005906001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005907001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t005907001.1	biological_process	GO:0042063	gliogenesis	"The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]	PANTHER
NV2t005908001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t005908001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t005908001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	PANTHER
NV2t005908002.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t005908002.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	PANTHER
NV2t005908003.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t005908003.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	PANTHER
NV2t005909001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	PANTHER
NV2t005909002.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	PANTHER
NV2t005910001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t005910001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005910001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005916001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t005916001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005917001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t005917001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005918001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t005918001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005918002.1	biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t005918002.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	OMA
NV2t005918002.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t005918002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005918002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t005918002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005918002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005921001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005921002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005923001.1	molecular_function	GO:0043023	ribosomal large subunit binding	"Binding to a large ribosomal subunit." [GOC:go_curators]	PANTHER
NV2t005924001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	PANTHER
NV2t005925001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005925001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t005925001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t005925001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t005925001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t005925001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t005925001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t005926001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005926002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005927001.1	biological_process	GO:0051503	adenine nucleotide transport	"The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t005927001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005927001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t005927001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t005932001.1	biological_process	GO:0019395	fatty acid oxidation	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t005932001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t005932001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t005932001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005932001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t005932001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t005932001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005932001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t005932002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t005932002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005932003.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t005932003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005934001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t005934001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t005934001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t005934001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t005934001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t005934001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t005935001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t005935001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t005935001.1	biological_process	GO:0006386	termination of RNA polymerase III transcription	"A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues." [GOC:mah, PMID:12944462, PMID:27371117]	PANTHER
NV2t005935001.1	biological_process	GO:0042779	obsolete tRNA 3'-trailer cleavage	"OBSOLETE. Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators]	OMA
NV2t005935001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t005935001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t005935001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t005936001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t005936001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005936002.1	biological_process	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	OMA
NV2t005936002.1	biological_process	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t005936002.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	OMA
NV2t005936002.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t005936002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005936002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005936002.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t005936002.1	cellular_component	GO:0097386	glial cell projection	"A prolongation or process extending from a glial cell." [GOC:mc]	OMA
NV2t005936002.1	molecular_function	GO:0001641	group II metabotropic glutamate receptor activity	"A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph]	OMA
NV2t005936002.1	molecular_function	GO:0097110	scaffold protein binding	"Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes." [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]	OMA
NV2t005938001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t005938001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t005938001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005938001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t005938001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t005938001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t005938001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t005938001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005939001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005939001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005941001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t005941001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t005942001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t005942001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t005944001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005945001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005945001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t005946002.1	biological_process	GO:0030719	P granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]	OMA
NV2t005946002.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	OMA
NV2t005946002.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t005947001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t005947001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t005947001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t005947001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t005947001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t005947001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t005947001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t005948001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005949001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005951001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005952001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005953001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005954001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t005960001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005960001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t005962001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t005962001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t005964001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t005964001.1	biological_process	GO:0019359	nicotinamide nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]	OMA
NV2t005964001.1	biological_process	GO:0019441	tryptophan catabolic process to kynurenine	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]	OMA
NV2t005964001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t005964001.1	biological_process	GO:0032787	monocarboxylic acid metabolic process	"The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]	OMA
NV2t005964001.1	biological_process	GO:0043420	anthranilate metabolic process	"The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [GOC:jl]	PANTHER
NV2t005964001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t005964001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t005964001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t005964001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t005964001.1	molecular_function	GO:0030429	kynureninase activity	"Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3]	InterPro
NV2t005965001.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	PANTHER
NV2t005965001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t005965002.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	PANTHER
NV2t005965002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t005965003.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	PANTHER
NV2t005965003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t005966001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005966002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005966003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005966004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005967001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005967001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	PANTHER
NV2t005967002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t005967002.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	PANTHER
NV2t005968001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005968002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t005969001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005969002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005969004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005969006.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005969007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005969007.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005969008.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005969009.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005969011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005969013.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t005973001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t005973001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t005973001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t005974001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005974001.1	molecular_function	GO:0003727	single-stranded RNA binding	"Binding to single-stranded RNA." [GOC:jl]	OMA
NV2t005974001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t005974001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005974001.1	molecular_function	GO:0035198	miRNA binding	"Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]	OMA
NV2t005974001.1	molecular_function	GO:0035198	miRNA binding	"Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]	PANTHER
NV2t005976001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005976001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t005976001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t005976001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t005976001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t005976002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t005977001.1	biological_process	GO:0042407	cristae formation	"The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t005977001.1	cellular_component	GO:0061617	MICOS complex	"Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]	InterPro
NV2t005977001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t005977002.1	cellular_component	GO:0061617	MICOS complex	"Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]	InterPro
NV2t005978001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t005978001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t005978001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t005978001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t005980001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005980001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t005980002.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t005980002.1	biological_process	GO:0006105	succinate metabolic process	"The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732]	OMA
NV2t005980002.1	biological_process	GO:0006121	mitochondrial electron transport, succinate to ubiquinone	"The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363]	OMA
NV2t005980002.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t005980002.1	cellular_component	GO:0005746	mitochondrial respirasome	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]	OMA
NV2t005980002.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t005980002.1	cellular_component	GO:0098803	respiratory chain complex	"Any protein complex that is part of a respiratory chain." [GOC:dos]	OMA
NV2t005980002.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t005980002.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t005980002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005980002.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t005980002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t005980002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t005980002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t005980003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005980003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t005980003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t005980004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005980004.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t005980005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005980005.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t005980005.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t005980006.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005980006.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t005980006.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t005980007.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005980007.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t005980007.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t005981001.1	biological_process	GO:0006801	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl]	OMA
NV2t005981001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t005981001.1	cellular_component	GO:0043020	NADPH oxidase complex	"A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]	PANTHER
NV2t005981001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t005981001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t005981001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t005981001.1	molecular_function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	"Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195]	OMA
NV2t005981001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t005981001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t005981001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t005981001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t005982001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t005982001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t005982001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t005982001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t005984001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t005987001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t005988001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t005988001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005988001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t005989001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t005990001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t005992001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t005992001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t005992001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t005992001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t005992001.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	PANTHER
NV2t005992001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t005993001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t005993001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	PANTHER
NV2t005997001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t005997001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006001001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t006001001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t006001001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006001001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t006001001.1	molecular_function	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	"Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]	OMA
NV2t006001001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006005001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006005001.1	biological_process	GO:0001933	negative regulation of protein phosphorylation	"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t006005001.1	biological_process	GO:0010225	response to UV-C	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:tb]	OMA
NV2t006005001.1	biological_process	GO:0031333	negative regulation of protein-containing complex assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t006005001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t006005001.1	biological_process	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	OMA
NV2t006005001.1	biological_process	GO:0034644	cellular response to UV	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]	OMA
NV2t006005001.1	biological_process	GO:0042542	response to hydrogen peroxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]	OMA
NV2t006005001.1	biological_process	GO:0043558	regulation of translational initiation in response to stress	"Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl]	OMA
NV2t006005001.1	biological_process	GO:0043618	obsolete regulation of transcription from RNA polymerase II promoter in response to stress	"OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]	OMA
NV2t006005001.1	biological_process	GO:0045666	positive regulation of neuron differentiation	"Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]	OMA
NV2t006005001.1	biological_process	GO:0045948	positive regulation of translational initiation	"Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t006005001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t006005001.1	biological_process	GO:0060733	GCN2-mediated signaling	"A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation." [PMID:27629041]	PANTHER
NV2t006005001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t006005001.1	biological_process	GO:0071417	cellular response to organonitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah]	OMA
NV2t006005001.1	biological_process	GO:0071468	cellular response to acidic pH	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, Wikipedia:PH]	OMA
NV2t006005001.1	biological_process	GO:0140467	integrated stress response signaling	"The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041]	OMA
NV2t006005001.1	biological_process	GO:1990138	neuron projection extension	"Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009]	OMA
NV2t006005001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t006005001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006006001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t006006001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t006006001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t006010001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t006013001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t006014001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t006014002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t006015001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t006016001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t006019001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t006019001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006019001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t006019001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t006019001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006021001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t006021001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006022001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006022001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006022001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t006022001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t006022001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006022001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006023001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006023001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006024001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006024001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t006025001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006025001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t006025002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006025002.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t006026001.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	PANTHER
NV2t006026002.1	biological_process	GO:0007130	synaptonemal complex assembly	"The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]	OMA
NV2t006026002.1	biological_process	GO:0007140	male meiotic nuclear division	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw]	OMA
NV2t006026002.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t006026002.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	PANTHER
NV2t006026002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006027001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t006027001.1	biological_process	GO:0048280	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	InterPro
NV2t006027001.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t006028002.1	biological_process	GO:0002702	positive regulation of production of molecular mediator of immune response	"Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]	OMA
NV2t006028002.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t006028002.1	biological_process	GO:0046626	regulation of insulin receptor signaling pathway	"Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]	OMA
NV2t006028002.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006028002.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t006028002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t006028002.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t006028002.1	cellular_component	GO:0034663	endoplasmic reticulum chaperone complex	"A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]	OMA
NV2t006028002.1	cellular_component	GO:0034663	endoplasmic reticulum chaperone complex	"A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]	PANTHER
NV2t006030001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t006030001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t006030001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t006030001.1	molecular_function	GO:0004563	beta-N-acetylhexosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]	OMA
NV2t006030001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t006030001.1	molecular_function	GO:0030247	polysaccharide binding	"Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]	InterPro
NV2t006030001.1	molecular_function	GO:0030247	polysaccharide binding	"Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah]	OMA
NV2t006032001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006033001.1	molecular_function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]	InterPro
NV2t006033001.1	molecular_function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]	PANTHER
NV2t006033002.1	molecular_function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]	PANTHER
NV2t006033003.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t006033003.1	molecular_function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]	InterPro
NV2t006033003.1	molecular_function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]	PANTHER
NV2t006033003.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t006033004.1	molecular_function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]	PANTHER
NV2t006033005.1	molecular_function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]	PANTHER
NV2t006033006.1	molecular_function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	"Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]	PANTHER
NV2t006034001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t006034001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006036001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t006047001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t006047001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006051001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t006053001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006053001.1	molecular_function	GO:0033781	cholesterol 24-hydroxylase activity	"Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]	InterPro
NV2t006053002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006053002.1	molecular_function	GO:0033781	cholesterol 24-hydroxylase activity	"Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]	InterPro
NV2t006054001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t006054001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	PANTHER
NV2t006054001.1	biological_process	GO:0006275	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	OMA
NV2t006054001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t006054001.1	cellular_component	GO:0005664	nuclear origin of replication recognition complex	"A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]	OMA
NV2t006054001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t006054002.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	PANTHER
NV2t006055001.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	OMA
NV2t006055001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t006055001.1	biological_process	GO:0046164	alcohol catabolic process	"The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]	OMA
NV2t006055001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t006055001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006055001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t006055001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006055001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t006055001.1	molecular_function	GO:0033781	cholesterol 24-hydroxylase activity	"Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]	InterPro
NV2t006056001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t006056001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t006056001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t006056001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t006057001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t006057001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006057001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006059001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t006059001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006060001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t006060001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006060002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t006060002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006060003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t006060003.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t006060003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006060004.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t006060004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t006060004.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t006060004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006060004.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006060005.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t006060005.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t006060005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006061001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t006061001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006065001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t006065001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t006065001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t006065001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006065001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006065001.1	cellular_component	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	OMA
NV2t006065001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t006065001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006065001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t006065001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t006065001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t006066001.1	biological_process	GO:0006529	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	InterPro
NV2t006066001.1	biological_process	GO:0006529	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	PANTHER
NV2t006066001.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t006066001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006066001.1	molecular_function	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532]	OMA
NV2t006067001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t006067001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006068001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t006068001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006068001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t006068001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t006068001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t006068002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006068002.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t006069001.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	PANTHER
NV2t006070001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t006070001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	PANTHER
NV2t006070001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t006070001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006070001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t006073001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006074001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t006074001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t006075001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t006077001.1	biological_process	GO:0001654	eye development	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]	OMA
NV2t006077001.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t006077001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t006077001.1	biological_process	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	OMA
NV2t006077001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t006077001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	PANTHER
NV2t006077001.1	biological_process	GO:0097435	supramolecular fiber organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]	OMA
NV2t006077001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006077001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006077001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t006077002.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	PANTHER
NV2t006077002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006079001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006079001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006079001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006079001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006079002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006079002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006081001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006081001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006081001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006081001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006081002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006081002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006081002.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t006081002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006081003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006081003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006081004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006081004.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006081004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006081004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006081005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006081005.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006081006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006081006.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006081007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006081007.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006084001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t006084001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t006084001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t006087001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t006087001.1	biological_process	GO:0061136	regulation of proteasomal protein catabolic process	"Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]	OMA
NV2t006087001.1	cellular_component	GO:0005575	cellular_component	"A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt]	OMA
NV2t006087001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	OMA
NV2t006087001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006087001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	InterPro
NV2t006087001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	OMA
NV2t006088001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006088001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t006088001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t006088001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t006088001.1	biological_process	GO:0010631	epithelial cell migration	"The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t006088001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t006088001.1	biological_process	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	OMA
NV2t006088001.1	biological_process	GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction	"Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade." [GOC:TermGenie]	OMA
NV2t006088001.1	biological_process	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t006088001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006088001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006088001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006088001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t006088001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t006088002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t006088002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t006088002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006088003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t006088003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t006088003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006088005.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t006088005.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t006088005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006090001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006090001.1	biological_process	GO:1990559	mitochondrial coenzyme A transmembrane transport	"The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11158296]	PANTHER
NV2t006090001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t006091001.1	biological_process	GO:0006069	obsolete ethanol oxidation	"OBSOLETE. An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah]	OMA
NV2t006091001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t006091001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t006091001.1	biological_process	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]	OMA
NV2t006091001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t006091001.1	biological_process	GO:0046185	aldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t006091001.1	biological_process	GO:1901564	organonitrogen compound metabolic process	"The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t006091001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t006091001.1	biological_process	GO:1990748	cellular detoxification	"Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw]	OMA
NV2t006091001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006091001.1	molecular_function	GO:0004022	alcohol dehydrogenase (NAD+) activity	"Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]	OMA
NV2t006091001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	OMA
NV2t006091001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006091001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006091001.1	molecular_function	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity	"Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284]	InterPro
NV2t006091001.1	molecular_function	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity	"Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284]	OMA
NV2t006091001.1	molecular_function	GO:0051903	S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity	"Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284]	PANTHER
NV2t006092001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t006092001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t006092001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t006092001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t006093001.1	cellular_component	GO:0045252	oxoglutarate dehydrogenase complex	"A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:10672230]	PANTHER
NV2t006093001.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t006093001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t006093002.1	cellular_component	GO:0045252	oxoglutarate dehydrogenase complex	"A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:10672230]	PANTHER
NV2t006093002.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t006093003.1	cellular_component	GO:0045252	oxoglutarate dehydrogenase complex	"A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:10672230]	PANTHER
NV2t006093003.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t006094001.1	biological_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	InterPro
NV2t006094001.1	biological_process	GO:0019646	aerobic electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]	OMA
NV2t006094001.1	biological_process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]	OMA
NV2t006094001.1	cellular_component	GO:0005746	mitochondrial respirasome	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]	OMA
NV2t006094001.1	cellular_component	GO:0070069	cytochrome complex	"A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah]	OMA
NV2t006094001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t006094001.1	cellular_component	GO:0098803	respiratory chain complex	"Any protein complex that is part of a respiratory chain." [GOC:dos]	OMA
NV2t006094001.1	cellular_component	GO:1902495	transmembrane transporter complex	"A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586]	OMA
NV2t006094001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t006095001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t006095001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	InterPro
NV2t006095001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006096001.1	cellular_component	GO:0044545	NSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]	PANTHER
NV2t006096002.1	cellular_component	GO:0044545	NSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]	PANTHER
NV2t006096003.1	cellular_component	GO:0044545	NSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]	PANTHER
NV2t006096004.1	cellular_component	GO:0044545	NSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]	PANTHER
NV2t006098001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t006098001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t006098001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t006098001.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t006098001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t006098001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t006098002.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t006098002.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t006101001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006101001.1	biological_process	GO:1990126	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	PANTHER
NV2t006101001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t006108001.1	biological_process	GO:0006116	NADH oxidation	"A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+." [GOC:ai]	InterPro
NV2t006108001.1	biological_process	GO:0006116	NADH oxidation	"A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+." [GOC:ai]	OMA
NV2t006108001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006108001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t006112001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006112001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006112001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006113001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006113001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006114001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t006114001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006114001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t006114001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t006114001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t006114001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006114001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t006116001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006116001.1	biological_process	GO:0051606	detection of stimulus	"The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]	OMA
NV2t006116001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006116001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006116001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006120001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006120001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006120001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t006120001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t006121001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t006121001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t006121001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t006121001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t006121001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006121001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006121001.1	molecular_function	GO:0031624	ubiquitin conjugating enzyme binding	"Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]	OMA
NV2t006121001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t006121001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t006121002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006121002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t006123001.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	InterPro
NV2t006123001.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	OMA
NV2t006123001.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	PANTHER
NV2t006123001.1	molecular_function	GO:0004757	sepiapterin reductase activity	"Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153]	OMA
NV2t006123002.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	InterPro
NV2t006123002.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	PANTHER
NV2t006124001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006124001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006124001.1	molecular_function	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	InterPro
NV2t006124001.1	molecular_function	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t006124001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t006124001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t006124001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t006125001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006125001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006125001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006125001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006125001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006125002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006125002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006125002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006125003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006125003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006125003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006127001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006127001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006127001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t006127001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006127001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t006127002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006127002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006128001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006131001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t006131001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006131001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006131001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006131002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006131002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006133001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	InterPro
NV2t006133001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t006133001.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t006133002.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	InterPro
NV2t006133002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006133002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t006133002.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t006133003.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	InterPro
NV2t006133003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t006133003.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t006133004.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t006133005.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t006133006.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t006133007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006133007.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t006134001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006134001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006135001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t006135001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t006135001.1	biological_process	GO:0008298	intracellular mRNA localization	"Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t006135001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t006135001.1	biological_process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]	OMA
NV2t006135001.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t006135001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t006135001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t006135001.1	biological_process	GO:1901798	positive regulation of signal transduction by p53 class mediator	"Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	OMA
NV2t006135001.1	biological_process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]	OMA
NV2t006135001.1	biological_process	GO:2000765	regulation of cytoplasmic translation	"Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	OMA
NV2t006135001.1	biological_process	GO:2001022	obsolete positive regulation of response to DNA damage stimulus	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]	OMA
NV2t006135001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t006135001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006135001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t006135001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t006135001.1	molecular_function	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	OMA
NV2t006135001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t006135001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006135001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006135002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006135003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006137001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t006137001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t006137002.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t006137002.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t006138001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t006138001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t006138001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006138001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006138001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006138001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006139001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t006139001.1	biological_process	GO:0032006	regulation of TOR signaling	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]	InterPro
NV2t006139001.1	biological_process	GO:0032008	positive regulation of TOR signaling	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t006139001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t006139001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	OMA
NV2t006139001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	PANTHER
NV2t006139001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t006139001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006139001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t006140001.1	biological_process	GO:0000291	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]	OMA
NV2t006140001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t006140001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t006140001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t006140001.1	biological_process	GO:0006304	DNA modification	"The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]	OMA
NV2t006140001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t006140001.1	biological_process	GO:0016072	rRNA metabolic process	"The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]	OMA
NV2t006140001.1	biological_process	GO:0016444	somatic cell DNA recombination	"Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]	OMA
NV2t006140001.1	biological_process	GO:0031126	sno(s)RNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea." [GOC:krc, GOC:mah, PMID:17284456]	OMA
NV2t006140001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t006140001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t006140001.1	biological_process	GO:0071027	nuclear RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]	OMA
NV2t006140001.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t006140001.1	cellular_component	GO:0000176	nuclear exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t006140001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t006140001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006141001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t006141001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t006141002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t006141002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t006141002.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t006141002.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t006141002.1	cellular_component	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t006141003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t006141003.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t006141004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t006141004.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	PANTHER
NV2t006144001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t006146001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t006146001.1	biological_process	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	OMA
NV2t006146001.1	biological_process	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	PANTHER
NV2t006146001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t006147001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t006147001.1	cellular_component	GO:0030175	filopodium	"Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]	OMA
NV2t006147001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t006147001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	OMA
NV2t006147001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t006148001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t006148001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006148001.1	cellular_component	GO:0097196	Shu complex	"A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p." [GOC:jh, PMID:15654096, PMID:19496932]	PANTHER
NV2t006148001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t006148002.1	cellular_component	GO:0097196	Shu complex	"A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p." [GOC:jh, PMID:15654096, PMID:19496932]	PANTHER
NV2t006149001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006149002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006150001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006150001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006150001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t006150001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006151003.1	cellular_component	GO:0008623	CHRAC	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192]	PANTHER
NV2t006151003.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t006151003.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t006154001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006156001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t006156001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006156001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006157001.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	OMA
NV2t006157001.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	PANTHER
NV2t006157001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006157001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t006159001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	OMA
NV2t006159001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t006159001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006159001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006160001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	InterPro
NV2t006160001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	OMA
NV2t006160001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	PANTHER
NV2t006160001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t006160001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	OMA
NV2t006162001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t006163001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t006165001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t006166001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t006166001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006167001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006167001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t006167001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t006167001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006167001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006168001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t006168001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t006168001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t006168001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t006168001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006169001.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	PANTHER
NV2t006169001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006169002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006169002.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t006169002.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	OMA
NV2t006169002.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	PANTHER
NV2t006169002.1	biological_process	GO:0097150	neuronal stem cell population maintenance	"Any process in by an organism or tissue maintains a population of neuronal stem cells." [CL:0000047, GOC:dos, GOC:yaf, PMID:11399758]	OMA
NV2t006169002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006169002.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t006169002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t006169002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006169002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006169002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006169002.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t006169002.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t006171001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t006171001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t006171001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t006171001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006171001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t006171001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t006171001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006171001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t006172001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t006172001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006174001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	InterPro
NV2t006174001.1	biological_process	GO:0032370	positive regulation of lipid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t006174001.1	biological_process	GO:0032892	positive regulation of organic acid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t006174001.1	biological_process	GO:0034764	positive regulation of transmembrane transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]	OMA
NV2t006174001.1	biological_process	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]	OMA
NV2t006174001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006174001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006174001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006174001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006174001.1	molecular_function	GO:0004467	long-chain fatty acid-CoA ligase activity	"Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [RHEA:15421]	OMA
NV2t006174002.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	InterPro
NV2t006174002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006175001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t006175001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t006175001.1	biological_process	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t006175001.1	biological_process	GO:0050796	regulation of insulin secretion	"Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai]	OMA
NV2t006175001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t006175001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006175001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006175001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t006175001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t006175001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t006175001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t006175001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t006175001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t006176001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t006176001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t006180001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t006180001.1	biological_process	GO:0035331	negative regulation of hippo signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t006180001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006183001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t006183001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006183001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006183001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006186001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006186001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006187001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t006187001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	OMA
NV2t006187001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006187001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t006187001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t006188001.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	OMA
NV2t006188001.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	OMA
NV2t006188001.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	PANTHER
NV2t006188001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t006188001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006188001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t006188001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t006188001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t006188001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t006188002.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	PANTHER
NV2t006188002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006191001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006191001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006192001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006192001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t006192001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t006192001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	PANTHER
NV2t006192002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006192002.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t006192002.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	PANTHER
NV2t006193001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006193001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t006193001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t006193001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	PANTHER
NV2t006196001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006196001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006196001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006198001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t006198001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006198002.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t006198002.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t006198002.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t006198002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006198002.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t006198002.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t006198002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006198002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t006198003.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t006198003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006199001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t006199001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	InterPro
NV2t006199001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t006199001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t006199001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t006199001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t006200001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006201001.1	biological_process	GO:0000096	sulfur amino acid metabolic process	"The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]	OMA
NV2t006201001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t006201001.1	biological_process	GO:0006750	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]	InterPro
NV2t006201001.1	biological_process	GO:0006750	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]	OMA
NV2t006201001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t006201001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t006201001.1	biological_process	GO:0009069	serine family amino acid metabolic process	"The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t006201001.1	biological_process	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	OMA
NV2t006201001.1	biological_process	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	OMA
NV2t006201001.1	biological_process	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	OMA
NV2t006201001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t006201001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t006201001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t006201001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006201001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006201001.1	biological_process	GO:0046685	response to arsenic-containing substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544]	OMA
NV2t006201001.1	cellular_component	GO:0017109	glutamate-cysteine ligase complex	"An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [PMID:9675072]	OMA
NV2t006201001.1	cellular_component	GO:0017109	glutamate-cysteine ligase complex	"An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [PMID:9675072]	PANTHER
NV2t006201001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t006201001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t006201001.1	molecular_function	GO:0004357	glutamate-cysteine ligase activity	"Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate." [EC:6.3.2.2, RHEA:13285]	OMA
NV2t006201001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006201001.1	molecular_function	GO:0016595	glutamate binding	"Binding to glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai]	OMA
NV2t006201001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t006207001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t006207001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006207001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t006207001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t006207001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t006209001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006209001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006209001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t006212001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t006212001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t006212001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t006212001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006212001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t006212001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006212001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	OMA
NV2t006215001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t006215001.1	biological_process	GO:0051643	endoplasmic reticulum localization	"Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t006215001.1	biological_process	GO:0061817	endoplasmic reticulum-plasma membrane tethering	"The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers." [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684]	InterPro
NV2t006215001.1	biological_process	GO:0140056	organelle localization by membrane tethering	"The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684]	OMA
NV2t006215001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t006215001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t006215001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t006216001.1	biological_process	GO:0061817	endoplasmic reticulum-plasma membrane tethering	"The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers." [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684]	InterPro
NV2t006216001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t006216001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t006218001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t006218001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006221001.1	biological_process	GO:0070131	positive regulation of mitochondrial translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]	PANTHER
NV2t006223001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t006223001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t006223001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t006223001.1	biological_process	GO:0061136	regulation of proteasomal protein catabolic process	"Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb]	OMA
NV2t006223001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	OMA
NV2t006223001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006223001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t006223001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006223001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t006223001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t006223001.1	molecular_function	GO:0061133	endopeptidase activator activity	"Binds to and increases the activity of an endopeptidase." [GOC:dph, GOC:tb]	OMA
NV2t006223001.1	molecular_function	GO:0061578	K63-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin." [GOC:dph, GOC:pg, PMID:18313383]	OMA
NV2t006223001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	OMA
NV2t006223001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t006225001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t006225001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t006225001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t006225001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t006225001.1	biological_process	GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343]	PANTHER
NV2t006225001.1	biological_process	GO:0044089	positive regulation of cellular component biogenesis	"Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t006225001.1	biological_process	GO:0045921	positive regulation of exocytosis	"Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t006225001.1	biological_process	GO:0072666	establishment of protein localization to vacuole	"The directed movement of a protein to a specific location in a vacuole." [GOC:mah]	OMA
NV2t006225001.1	biological_process	GO:1902115	regulation of organelle assembly	"Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]	OMA
NV2t006225001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t006225001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006225001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t006225001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t006225001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t006225001.1	molecular_function	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	OMA
NV2t006230001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006231001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006231001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t006231001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t006232001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t006234001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006234002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006236001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t006236001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t006236001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006236001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006236001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006236001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006237001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006240001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006240001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006240001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006240001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t006241001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006241001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006241001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006241001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t006243001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006243001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006243001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006243001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t006244001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	PANTHER
NV2t006244002.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t006244002.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	PANTHER
NV2t006244002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006244003.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	PANTHER
NV2t006245001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006245001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006247001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006247001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t006247001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006247002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006247002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t006247002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006247003.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t006247003.1	biological_process	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	OMA
NV2t006247003.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t006247003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006247003.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t006247003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t006247003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006247003.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t006247003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006247003.1	molecular_function	GO:0015269	calcium-activated potassium channel activity	"Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	OMA
NV2t006248001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t006248001.1	biological_process	GO:0019933	cAMP-mediated signaling	"An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling]	PANTHER
NV2t006248002.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t006248002.1	biological_process	GO:0019933	cAMP-mediated signaling	"An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling]	PANTHER
NV2t006249001.1	biological_process	GO:0000710	meiotic mismatch repair	"A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855]	OMA
NV2t006249001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t006249001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t006249001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t006249001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t006249001.1	biological_process	GO:0008340	determination of adult lifespan	"The pathways that regulate the duration of the adult phase of the life-cycle of an animal." [PMID:25561524, PMID:273723695, PMID:3424805]	OMA
NV2t006249001.1	biological_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t006249001.1	biological_process	GO:0009411	response to UV	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]	OMA
NV2t006249001.1	biological_process	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	OMA
NV2t006249001.1	biological_process	GO:0016444	somatic cell DNA recombination	"Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]	OMA
NV2t006249001.1	biological_process	GO:0032781	positive regulation of ATP-dependent activity	"Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah]	OMA
NV2t006249001.1	biological_process	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006249001.1	biological_process	GO:0043570	maintenance of DNA repeat elements	"Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl]	OMA
NV2t006249001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	OMA
NV2t006249001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t006249001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t006249001.1	molecular_function	GO:0000400	four-way junction DNA binding	"Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]	OMA
NV2t006249001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t006249001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006249001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t006249001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t006249001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t006249001.1	molecular_function	GO:0032357	oxidized purine DNA binding	"Binding to a DNA region containing an oxidized purine residue." [GOC:vk]	OMA
NV2t006249001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t006249001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t006249001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t006249001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t006251001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006251001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006252001.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	OMA
NV2t006252001.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	PANTHER
NV2t006252001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006252001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t006252001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t006252001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t006252002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t006252002.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t006252003.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	PANTHER
NV2t006253001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006253001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t006253001.1	biological_process	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t006253001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t006253001.1	cellular_component	GO:0000791	euchromatin	"A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]	OMA
NV2t006253001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006253001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t006253001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006253001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t006253001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t006253001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t006253001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t006254001.1	biological_process	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	OMA
NV2t006254001.1	biological_process	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	OMA
NV2t006254001.1	biological_process	GO:0042542	response to hydrogen peroxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]	OMA
NV2t006254001.1	biological_process	GO:0043523	regulation of neuron apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t006254001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t006254001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t006254001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006254001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t006254001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t006254001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006254001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006255001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	PANTHER
NV2t006255002.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	PANTHER
NV2t006255003.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	PANTHER
NV2t006256001.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	PANTHER
NV2t006256003.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	PANTHER
NV2t006256004.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	PANTHER
NV2t006257001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006257002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006257003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006258001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	PANTHER
NV2t006258002.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	PANTHER
NV2t006258003.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	PANTHER
NV2t006266001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006266001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t006268001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t006268001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006268002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t006268002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006269001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t006269001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t006269001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t006269002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t006269002.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t006269003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t006269003.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t006270001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t006270001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t006270001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t006270001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006270001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t006272001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t006273001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t006273001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t006275001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t006275001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006275002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t006275002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006277001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t006277001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t006278001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t006280001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t006281001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t006281001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t006281001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t006281002.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t006281002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t006281002.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t006281003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t006281003.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t006281004.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t006281004.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t006283001.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t006283002.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t006283002.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t006283002.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t006283002.1	molecular_function	GO:0032027	myosin light chain binding	"Binding to a light chain of a myosin complex." [GOC:mah]	OMA
NV2t006283003.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t006283004.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t006283005.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t006283006.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t006283008.1	cellular_component	GO:0097224	sperm connecting piece	"The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830]	InterPro
NV2t006284001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t006285001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t006285001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	InterPro
NV2t006286001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006286001.1	molecular_function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	"Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t006286001.1	molecular_function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	"Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions." [GOC:bf, GOC:go_curators]	OMA
NV2t006286004.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t006286005.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t006287001.1	biological_process	GO:0000086	G2/M transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]	OMA
NV2t006287001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t006287001.1	biological_process	GO:0009953	dorsal/ventral pattern formation	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t006287001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t006287001.1	biological_process	GO:0030513	positive regulation of BMP signaling pathway	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]	OMA
NV2t006287001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t006287001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t006287001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t006287001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006287001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t006287001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006288001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t006288001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t006288001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006288001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006288001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006288001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t006288001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006288001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006288002.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	PANTHER
NV2t006288003.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	PANTHER
NV2t006288004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006291001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t006291002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t006292001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t006292001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t006292001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t006292001.1	cellular_component	GO:0097731	9+0 non-motile cilium	"A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:22118931]	OMA
NV2t006292002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t006292003.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t006293001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006293001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t006293002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006293002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t006293003.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t006293003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006293003.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t006293003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t006293003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006293003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t006293003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t006293003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t006293004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006293004.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t006293005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006293005.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t006294001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t006294001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t006294001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006294001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t006294001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t006294001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006294001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006297001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t006299001.1	biological_process	GO:0051793	medium-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism]	PANTHER
NV2t006299002.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t006299002.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t006299002.1	biological_process	GO:0051791	medium-chain fatty acid metabolic process	"The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolisms]	OMA
NV2t006299002.1	biological_process	GO:0051793	medium-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism]	PANTHER
NV2t006299002.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	OMA
NV2t006299002.1	molecular_function	GO:0034338	short-chain carboxylesterase activity	"Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp]	OMA
NV2t006304001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	OMA
NV2t006304001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t006304001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t006304001.1	cellular_component	GO:0045254	pyruvate dehydrogenase complex	"A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:36863425]	InterPro
NV2t006304001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t006304001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t006304001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t006304001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t006304001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t006304001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t006304001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t006304002.1	cellular_component	GO:0045254	pyruvate dehydrogenase complex	"A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:36863425]	InterPro
NV2t006304002.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t006305001.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	PANTHER
NV2t006306001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	InterPro
NV2t006306001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	OMA
NV2t006306001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	PANTHER
NV2t006306001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t006306001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	OMA
NV2t006309001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t006309001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t006309001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	InterPro
NV2t006309001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t006309001.1	biological_process	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	OMA
NV2t006309001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t006309001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t006309001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t006309001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	OMA
NV2t006309001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t006309001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t006309001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t006309001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t006309001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t006309001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006309001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006309001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t006309001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t006309001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t006309001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t006309001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t006309001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t006312001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t006312001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t006313002.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t006313003.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t006313004.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t006313004.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t006313004.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t006313004.1	biological_process	GO:0009314	response to radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]	OMA
NV2t006313004.1	biological_process	GO:0065004	protein-DNA complex assembly	"The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl]	OMA
NV2t006313004.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	OMA
NV2t006313004.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t006313004.1	cellular_component	GO:0000439	transcription factor TFIIH core complex	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]	OMA
NV2t006313004.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t006313004.1	cellular_component	GO:0005675	transcription factor TFIIH holo complex	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]	OMA
NV2t006313004.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t006314001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t006314001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006316001.1	biological_process	GO:0036088	D-serine catabolic process	"The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:imk]	PANTHER
NV2t006321001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t006321001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t006324001.1	biological_process	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t006324001.1	biological_process	GO:0046483	obsolete heterocycle metabolic process	"OBSOLETE. The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732]	OMA
NV2t006324001.1	biological_process	GO:0097176	epoxide metabolic process	"The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [GOC:rs, PMID:15822179]	PANTHER
NV2t006324001.1	biological_process	GO:1901360	organic cyclic compound metabolic process	"The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]	OMA
NV2t006324001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t006324001.1	molecular_function	GO:0004301	epoxide hydrolase activity	"Catalysis of the reaction: an epoxide + H2O = an ethanediol." [EC:3.3.2.10]	OMA
NV2t006324001.1	molecular_function	GO:0016803	ether hydrolase activity	"Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai]	InterPro
NV2t006324002.1	biological_process	GO:0097176	epoxide metabolic process	"The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [GOC:rs, PMID:15822179]	PANTHER
NV2t006324002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t006324002.1	molecular_function	GO:0016803	ether hydrolase activity	"Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai]	InterPro
NV2t006325001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t006326001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t006326001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t006326001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t006326002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t006326002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t006326002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t006326002.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t006326002.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	OMA
NV2t006326003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t006326003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t006326004.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t006326004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t006326004.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t006327001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t006327001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t006327001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	InterPro
NV2t006327001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t006327001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t006327001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t006327001.1	molecular_function	GO:0016835	carbon-oxygen lyase activity	"Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]	OMA
NV2t006327001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t006327001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006328001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t006328001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t006329001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t006329001.1	biological_process	GO:0051438	regulation of ubiquitin-protein transferase activity	"Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]	OMA
NV2t006329001.1	biological_process	GO:2000001	regulation of DNA damage checkpoint	"Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]	OMA
NV2t006329001.1	biological_process	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t006329001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006329001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006329001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t006329001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006329001.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t006329001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t006330001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006330001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006330001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t006333001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t006333001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t006333001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	InterPro
NV2t006333001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t006333001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t006333001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t006333001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t006335001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006336001.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	InterPro
NV2t006340001.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	InterPro
NV2t006341001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006341001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006341001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006342001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t006342001.1	biological_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t006342001.1	biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	OMA
NV2t006342001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006342001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t006342001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t006342001.1	molecular_function	GO:0060590	ATPase regulator activity	"Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]	OMA
NV2t006342001.1	molecular_function	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t006343001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	InterPro
NV2t006344001.1	cellular_component	GO:0099055	obsolete integral component of postsynaptic membrane	"OBSOLETE. The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos]	PANTHER
NV2t006345001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006345001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t006345001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006348001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006348001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006348001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006348001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006348001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006350001.1	cellular_component	GO:1990124	messenger ribonucleoprotein complex	"A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules." [GOC:bf, PMID:15574591, PMID:21915786]	PANTHER
NV2t006351001.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	OMA
NV2t006351001.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	PANTHER
NV2t006351001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t006351001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006351001.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	OMA
NV2t006351001.1	molecular_function	GO:0097109	neuroligin family protein binding	"Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation." [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692]	OMA
NV2t006351002.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	PANTHER
NV2t006351002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006351003.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	PANTHER
NV2t006351003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006351004.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	PANTHER
NV2t006351004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006351005.1	cellular_component	GO:0016010	dystrophin-associated glycoprotein complex	"A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]	PANTHER
NV2t006351005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006356001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t006356001.1	biological_process	GO:0032008	positive regulation of TOR signaling	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t006356001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t006356001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t006356001.1	biological_process	GO:1903432	regulation of TORC1 signaling	"Any process that modulates the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie]	OMA
NV2t006356001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006356001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t006356001.1	cellular_component	GO:1905360	GTPase complex	"A protein complex which is capable of GTPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006]	OMA
NV2t006356001.1	cellular_component	GO:1990131	Gtr1-Gtr2 GTPase complex	"A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins." [GOC:rb, PMID:10388807, PMID:16143306]	PANTHER
NV2t006356001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t006356001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006356001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t006356001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t006356001.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	OMA
NV2t006359001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t006359001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006359001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t006359001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t006364001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t006364001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006364001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t006364001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t006364001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t006364001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t006364001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t006365001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006366001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t006366002.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t006366003.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t006366004.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t006366005.1	biological_process	GO:0003352	regulation of cilium movement	"Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]	OMA
NV2t006366005.1	biological_process	GO:0060285	cilium-dependent cell motility	"Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]	OMA
NV2t006366005.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	OMA
NV2t006366005.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t006366005.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t006366006.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t006366007.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t006367001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006367001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006367001.1	molecular_function	GO:0008474	palmitoyl-(protein) hydrolase activity	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]	OMA
NV2t006368001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t006368001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t006368001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006368001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t006368001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t006368001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t006368001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t006368002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006368003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006368004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006369001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t006369002.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t006369002.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t006369002.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t006369002.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t006369002.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t006369002.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t006369002.1	biological_process	GO:1903644	regulation of chaperone-mediated protein folding	"Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412]	OMA
NV2t006369002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006369002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006369002.1	molecular_function	GO:0005172	vascular endothelial growth factor receptor binding	"Binding to a vascular endothelial growth factor receptor." [GOC:ai]	OMA
NV2t006369002.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t006370001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t006370001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t006370001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t006372001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t006372001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006372001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006372001.1	molecular_function	GO:0008417	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t006372001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t006373001.1	cellular_component	GO:0043564	Ku70:Ku80 complex	"Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]	PANTHER
NV2t006375001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t006375001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t006375001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t006375001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t006375001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t006375001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t006375001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t006375001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006375001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006375001.1	molecular_function	GO:0005104	fibroblast growth factor receptor binding	"Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb]	OMA
NV2t006375001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t006375001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t006376001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t006380002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006380003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006380004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006380005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006380006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006380007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006381001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t006381001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t006381001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006381001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t006381001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006381001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t006381001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t006382001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	InterPro
NV2t006382001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t006382001.1	biological_process	GO:0007423	sensory organ development	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]	OMA
NV2t006382001.1	biological_process	GO:0007549	sex-chromosome dosage compensation	"Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes." [GOC:ems, PMID:11498577, PMID:30049999, PMID:35306885]	OMA
NV2t006382001.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t006382001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	OMA
NV2t006382001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t006382001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t006382001.1	biological_process	GO:0060541	respiratory system development	"The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]	OMA
NV2t006382001.1	biological_process	GO:0140719	constitutive heterochromatin formation	"The compaction of chromatin into a conformation that is refactory to transcription." [PMID:17936700]	OMA
NV2t006382001.1	biological_process	GO:2000780	negative regulation of double-strand break repair	"Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t006382001.1	biological_process	GO:2000781	positive regulation of double-strand break repair	"Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t006382001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t006382001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t006382001.1	cellular_component	GO:0000805	X chromosome	"The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system]	OMA
NV2t006382001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t006382001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006382001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t006382001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t006382002.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	InterPro
NV2t006382002.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t006383001.1	biological_process	GO:0006091	generation of precursor metabolites and energy	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]	OMA
NV2t006383001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	InterPro
NV2t006383001.1	biological_process	GO:0006693	prostaglandin metabolic process	"The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]	OMA
NV2t006383001.1	biological_process	GO:0050665	hydrogen peroxide biosynthetic process	"The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai]	OMA
NV2t006383001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t006383001.1	biological_process	GO:0140493	very long-chain fatty acid beta-oxidation	"A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:ha, PMID:17028011, PMID:32169171]	OMA
NV2t006383001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t006383001.1	molecular_function	GO:0005504	fatty acid binding	"Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]	OMA
NV2t006383001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t006383001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t006383001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t006383001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t006383001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t006383001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t006384001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t006384001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t006384001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006384001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t006384001.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t006384001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	OMA
NV2t006384001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006384001.1	molecular_function	GO:0005432	calcium:sodium antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]	OMA
NV2t006385001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006385001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006385002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006385002.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006385003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006385003.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006386001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006386001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006389001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006389001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006390001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006390001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006391001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t006391001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t006391001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006391001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006391001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006391002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006391002.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006391003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006391003.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006391004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006391004.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006392001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t006392001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t006392001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006392001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006392001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006392002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006392002.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006392003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006392003.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006393001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t006393001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t006393001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t006393001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t006393001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t006393001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t006393001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006393001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006393001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t006393002.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t006394001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006394001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t006394001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t006395001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t006395001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006395001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006396001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t006396001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t006396001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006396001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t006396001.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	PANTHER
NV2t006396001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006399001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t006399001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	PANTHER
NV2t006399001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t006399001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006400001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006400001.1	biological_process	GO:0045719	negative regulation of glycogen biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	PANTHER
NV2t006400001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006400002.1	biological_process	GO:0005979	regulation of glycogen biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	OMA
NV2t006400002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006400002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006400002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t006400002.1	biological_process	GO:0045719	negative regulation of glycogen biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	PANTHER
NV2t006400002.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t006400002.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006400002.1	biological_process	GO:0070874	negative regulation of glycogen metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]	OMA
NV2t006400002.1	biological_process	GO:0090276	regulation of peptide hormone secretion	"Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]	OMA
NV2t006400002.1	biological_process	GO:0097009	energy homeostasis	"Any process involved in the balance between food intake (energy input) and energy expenditure." [GOC:yaf, PMID:15919751]	OMA
NV2t006400002.1	biological_process	GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	"OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]	OMA
NV2t006400002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006400002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006400002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t006400002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006400002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006400002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t006400003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006400003.1	biological_process	GO:0045719	negative regulation of glycogen biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	PANTHER
NV2t006400003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006400004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006400004.1	biological_process	GO:0045719	negative regulation of glycogen biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	PANTHER
NV2t006400004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006401001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006401001.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t006401002.1	biological_process	GO:0010043	response to zinc ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]	OMA
NV2t006401002.1	biological_process	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t006401002.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t006401002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006401002.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t006401002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006401002.1	cellular_component	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	OMA
NV2t006401002.1	molecular_function	GO:0005385	zinc ion transmembrane transporter activity	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t006402001.1	biological_process	GO:0010496	intercellular transport	"The movement of substances between cells." [GOC:dhl]	OMA
NV2t006402001.1	biological_process	GO:0045785	positive regulation of cell adhesion	"Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators]	OMA
NV2t006402001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t006402001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006402001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006402001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006402001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t006402001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006402001.1	molecular_function	GO:0015250	water channel activity	"Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006402002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006402002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006403001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t006403002.1	biological_process	GO:0006172	ADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai]	InterPro
NV2t006403002.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	InterPro
NV2t006403002.1	molecular_function	GO:0016776	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	InterPro
NV2t006403002.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t006405001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t006409001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006409001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t006409001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t006409001.1	molecular_function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t006409001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006409001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t006411001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t006413001.1	biological_process	GO:0006820	monoatomic anion transport	"The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t006413001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006413001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006413001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006413001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006413001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t006413002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006413002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006413002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t006413003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006413003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006413003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t006413004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006413004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006413004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t006413005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006413005.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006413005.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t006414001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006414001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006414001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006416001.1	molecular_function	GO:0008449	N-acetylglucosamine-6-sulfatase activity	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]	PANTHER
NV2t006416002.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t006416002.1	biological_process	GO:0006939	smooth muscle contraction	"A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]	OMA
NV2t006416002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t006416002.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t006416002.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t006416002.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t006416002.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t006416002.1	biological_process	GO:0030177	positive regulation of Wnt signaling pathway	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t006416002.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t006416002.1	biological_process	GO:0030201	heparan sulfate proteoglycan metabolic process	"The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]	OMA
NV2t006416002.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t006416002.1	biological_process	GO:0030513	positive regulation of BMP signaling pathway	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]	OMA
NV2t006416002.1	biological_process	GO:0035107	appendage morphogenesis	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]	OMA
NV2t006416002.1	biological_process	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t006416002.1	biological_process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t006416002.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t006416002.1	biological_process	GO:0050680	negative regulation of epithelial cell proliferation	"Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai]	OMA
NV2t006416002.1	biological_process	GO:0051093	negative regulation of developmental process	"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t006416002.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t006416002.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t006416002.1	biological_process	GO:0060384	innervation	"The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue." [GOC:dph, GOC:sart]	OMA
NV2t006416002.1	biological_process	GO:0060688	regulation of morphogenesis of a branching structure	"Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph]	OMA
NV2t006416002.1	biological_process	GO:0061448	connective tissue development	"The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF]	OMA
NV2t006416002.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t006416002.1	biological_process	GO:1905330	regulation of morphogenesis of an epithelium	"Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]	OMA
NV2t006416002.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t006416002.1	biological_process	GO:2000027	regulation of animal organ morphogenesis	"Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol]	OMA
NV2t006416002.1	biological_process	GO:2000242	negative regulation of reproductive process	"Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah]	OMA
NV2t006416002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006416002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006416002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t006416002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006416002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t006416002.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t006416002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t006416002.1	molecular_function	GO:0005539	glycosaminoglycan binding	"Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t006416002.1	molecular_function	GO:0008449	N-acetylglucosamine-6-sulfatase activity	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]	OMA
NV2t006416002.1	molecular_function	GO:0008449	N-acetylglucosamine-6-sulfatase activity	"Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]	PANTHER
NV2t006418001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t006418001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t006419001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t006419001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t006419001.1	molecular_function	GO:0070180	large ribosomal subunit rRNA binding	"Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]	PANTHER
NV2t006420001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006421001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006422001.1	cellular_component	GO:0030018	Z disc	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]	PANTHER
NV2t006424001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006429001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t006429001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t006429001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t006429001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t006429001.1	biological_process	GO:1902117	positive regulation of organelle assembly	"Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]	OMA
NV2t006429001.1	biological_process	GO:1903729	regulation of plasma membrane organization	"Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900]	OMA
NV2t006429001.1	cellular_component	GO:0002102	podosome	"An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]	OMA
NV2t006429001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t006429001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t006429001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t006429001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t006429001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006436001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t006436001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t006436001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t006436001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006436001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006436001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006437001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t006437001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006437002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006437002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t006438001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t006438001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006439001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t006439001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006440001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006441001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t006441001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006444001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006445001.1	biological_process	GO:0060623	regulation of chromosome condensation	"Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb]	OMA
NV2t006445001.1	biological_process	GO:0071922	regulation of cohesin loading	"Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138]	OMA
NV2t006445001.1	biological_process	GO:0071922	regulation of cohesin loading	"Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138]	PANTHER
NV2t006445002.1	biological_process	GO:0071922	regulation of cohesin loading	"Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138]	PANTHER
NV2t006446001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006447001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006449001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006450001.1	cellular_component	GO:0033588	elongator holoenzyme complex	"A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]	InterPro
NV2t006451001.1	cellular_component	GO:0140007	KICSTOR complex	"A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2." [PMID:28199306]	PANTHER
NV2t006452001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t006452001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006453001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	InterPro
NV2t006453001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t006453001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	PANTHER
NV2t006453001.1	biological_process	GO:0043436	oxoacid metabolic process	"The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]	OMA
NV2t006453001.1	biological_process	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	OMA
NV2t006453001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006453001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006453001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t006453001.1	molecular_function	GO:0004427	inorganic diphosphate phosphatase activity	"Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate." [EC:3.6.1.1, RHEA:24576]	OMA
NV2t006457001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t006457001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t006457001.1	biological_process	GO:0045879	negative regulation of smoothened signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t006457001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006457001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t006457001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t006457001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t006460001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006460001.1	biological_process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	InterPro
NV2t006460001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006460001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t006461001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	InterPro
NV2t006461001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t006462001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006463001.1	molecular_function	GO:0004784	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]	OMA
NV2t006463001.1	molecular_function	GO:0016532	superoxide dismutase copper chaperone activity	"A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278]	PANTHER
NV2t006463001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t006463001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t006463002.1	molecular_function	GO:0016532	superoxide dismutase copper chaperone activity	"A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278]	PANTHER
NV2t006463002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t006465001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t006465001.1	cellular_component	GO:0005689	U12-type spliceosomal complex	"Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]	PANTHER
NV2t006465001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t006465001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t006465001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006466001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t006466001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t006466001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t006466001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t006466001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t006466002.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t006466003.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t006467001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	InterPro
NV2t006467002.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	InterPro
NV2t006468001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	PANTHER
NV2t006469001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	PANTHER
NV2t006469002.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	PANTHER
NV2t006470001.1	biological_process	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	InterPro
NV2t006470001.1	biological_process	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	OMA
NV2t006470001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006470001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t006470001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006470001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t006470001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t006470001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t006472001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006472001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006473001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t006473001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t006474001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t006475001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t006475001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	InterPro
NV2t006476001.1	biological_process	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t006476001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	PANTHER
NV2t006476001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t006476001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t006476001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t006476001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006476001.1	molecular_function	GO:0005520	insulin-like growth factor binding	"Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732]	OMA
NV2t006478002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006480001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t006480001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t006480001.1	biological_process	GO:0016539	intein-mediated protein splicing	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]	InterPro
NV2t006480001.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t006484001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t006484001.1	biological_process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]	OMA
NV2t006484001.1	biological_process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]	PANTHER
NV2t006484001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t006484001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006484001.1	molecular_function	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]	OMA
NV2t006485001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t006485001.1	biological_process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]	OMA
NV2t006485001.1	biological_process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]	PANTHER
NV2t006485001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t006485001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006485001.1	molecular_function	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]	OMA
NV2t006486001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006486001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t006486001.1	biological_process	GO:1990559	mitochondrial coenzyme A transmembrane transport	"The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11158296]	PANTHER
NV2t006486001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t006486001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t006489001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t006489001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t006489001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t006489001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t006489001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t006489001.1	biological_process	GO:0060393	obsolete regulation of pathway-restricted SMAD protein phosphorylation	"OBSOLETE. Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t006489001.1	biological_process	GO:0060395	SMAD protein signal transduction	"An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF]	OMA
NV2t006489001.1	biological_process	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	OMA
NV2t006489001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006489001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t006489001.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t006489001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t006489001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t006490001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t006490002.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t006490002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t006490002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t006493001.1	molecular_function	GO:0071532	ankyrin repeat binding	"Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure." [GOC:mah, InterPro:IPR002110]	PANTHER
NV2t006495001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t006495001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t006497001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t006497001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006497001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006497001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006499001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t006499001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t006499001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006499001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006499001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006499001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t006499002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006499002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006502001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006502001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006503001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t006516001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006516001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t006516002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006516002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t006517001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006519001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006520001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t006520001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t006520002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t006520003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t006520004.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t006521001.1	biological_process	GO:0002082	regulation of oxidative phosphorylation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph]	OMA
NV2t006521001.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	InterPro
NV2t006521001.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	OMA
NV2t006521001.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	PANTHER
NV2t006521001.1	biological_process	GO:0045595	regulation of cell differentiation	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]	OMA
NV2t006521001.1	biological_process	GO:0050796	regulation of insulin secretion	"Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai]	OMA
NV2t006521001.1	biological_process	GO:0070131	positive regulation of mitochondrial translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]	OMA
NV2t006521001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t006521001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t006521001.1	cellular_component	GO:0042645	mitochondrial nucleoid	"The region of a mitochondrion to which the DNA is confined." [GOC:jl]	OMA
NV2t006522001.1	biological_process	GO:0010507	negative regulation of autophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t006522001.1	biological_process	GO:0010922	positive regulation of phosphatase activity	"Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t006522001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t006522001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	PANTHER
NV2t006522001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t006522001.1	biological_process	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t006522001.1	biological_process	GO:1903725	regulation of phospholipid metabolic process	"Any process that modulates the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]	OMA
NV2t006522001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006522001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006522001.1	molecular_function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]	OMA
NV2t006522001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t006524001.1	biological_process	GO:0007040	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	OMA
NV2t006524001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t006524001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t006524001.1	cellular_component	GO:0030136	clathrin-coated vesicle	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]	OMA
NV2t006524001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	OMA
NV2t006524001.1	molecular_function	GO:1902936	phosphatidylinositol bisphosphate binding	"Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]	PANTHER
NV2t006524002.1	molecular_function	GO:1902936	phosphatidylinositol bisphosphate binding	"Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]	PANTHER
NV2t006524003.1	molecular_function	GO:1902936	phosphatidylinositol bisphosphate binding	"Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]	PANTHER
NV2t006525001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006525001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006526001.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	InterPro
NV2t006526001.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	PANTHER
NV2t006526002.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	InterPro
NV2t006526002.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	PANTHER
NV2t006529001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t006530001.1	biological_process	GO:0018126	protein hydroxylation	"The addition of a hydroxy group to a protein amino acid." [GOC:ai]	OMA
NV2t006530001.1	biological_process	GO:0018193	peptidyl-amino acid modification	"The alteration of an amino acid residue in a peptide." [GOC:mah]	InterPro
NV2t006530001.1	biological_process	GO:0018197	peptidyl-aspartic acid modification	"The modification of peptidyl-aspartic acid." [GOC:ma]	OMA
NV2t006530001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006530001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t006530001.1	molecular_function	GO:0062101	peptidyl-aspartic acid 3-dioxygenase activity	"Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2." [PMID:1378441, PMID:1856229, RHEA:11508]	InterPro
NV2t006530001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t006531001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t006531001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t006531001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t006531001.1	biological_process	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	"The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai]	OMA
NV2t006531001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t006531001.1	biological_process	GO:0030210	heparin biosynthetic process	"The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]	OMA
NV2t006531001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006531001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t006531001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t006531001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t006531001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t006531001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t006531001.1	molecular_function	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	"Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN]	OMA
NV2t006532001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t006533001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t006533001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t006534001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006534001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006534001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t006534001.1	molecular_function	GO:0004045	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	InterPro
NV2t006534001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006534001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t006534001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t006535001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t006537001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t006539001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t006539001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t006539001.1	biological_process	GO:0009435	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	InterPro
NV2t006539001.1	biological_process	GO:0019359	nicotinamide nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]	OMA
NV2t006539001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t006539001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006539001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006539001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t006539001.1	molecular_function	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532]	OMA
NV2t006540001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t006540001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t006540001.1	biological_process	GO:0015937	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	InterPro
NV2t006540001.1	biological_process	GO:0015937	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	PANTHER
NV2t006540001.1	biological_process	GO:0034030	ribonucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t006540001.1	biological_process	GO:0034033	purine nucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t006540001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006540001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t006540001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t006540001.1	molecular_function	GO:0070566	adenylyltransferase activity	"Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]	OMA
NV2t006541001.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	OMA
NV2t006541001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t006541001.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t006541001.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	OMA
NV2t006544001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t006544001.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	PANTHER
NV2t006544001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t006544001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t006545001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t006545001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t006545001.1	biological_process	GO:0060285	cilium-dependent cell motility	"Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]	OMA
NV2t006545001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t006545001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t006545001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t006545001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t006545001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t006546001.1	molecular_function	GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	"Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine." [PMID:19014349, PMID:31869331, RHEA:27606]	InterPro
NV2t006546002.1	molecular_function	GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	"Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine." [PMID:19014349, PMID:31869331, RHEA:27606]	InterPro
NV2t006546003.1	molecular_function	GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	"Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine." [PMID:19014349, PMID:31869331, RHEA:27606]	InterPro
NV2t006547001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006547001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006548001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t006548001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t006548001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t006548001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t006548001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t006552001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006552001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006553001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t006553001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t006553001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t006553001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t006553001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006553001.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	InterPro
NV2t006553001.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	OMA
NV2t006554001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006554001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t006554001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006554001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006554001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006554001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006558001.1	biological_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t006558001.1	biological_process	GO:0010043	response to zinc ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]	OMA
NV2t006558001.1	biological_process	GO:0010224	response to UV-B	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb]	OMA
NV2t006558001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t006558001.1	biological_process	GO:0034644	cellular response to UV	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]	OMA
NV2t006558001.1	biological_process	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	OMA
NV2t006558001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006558001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006558001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t006559001.1	cellular_component	GO:1990907	beta-catenin-TCF complex	"A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors." [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]	PANTHER
NV2t006559002.1	cellular_component	GO:1990907	beta-catenin-TCF complex	"A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors." [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]	PANTHER
NV2t006563001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t006563001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t006563001.1	biological_process	GO:0006896	Golgi to vacuole transport	"The directed movement of substances from the Golgi to the vacuole." [GOC:ai]	OMA
NV2t006563001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t006563001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t006563001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t006563001.1	biological_process	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	OMA
NV2t006563001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t006563001.1	biological_process	GO:0048280	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	PANTHER
NV2t006563001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t006563001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t006563001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t006563001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006563001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t006563001.1	cellular_component	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	OMA
NV2t006563001.1	cellular_component	GO:0030662	coated vesicle membrane	"The lipid bilayer surrounding a coated vesicle." [GOC:mah]	OMA
NV2t006563001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t006563001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t006563001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t006563001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t006564001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t006564001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t006564001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006564001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t006564001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006564001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006565001.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t006566001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006566001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t006566001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t006567001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006567001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006567001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t006567001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t006567001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t006568001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t006568001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006568001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t006568001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t006572001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006572001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006572001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t006572001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t006572001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t006577001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t006579001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t006579001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t006579001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t006579001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t006579001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006579001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t006579001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t006579001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006579001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006579001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006579001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t006579001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t006579001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t006580001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t006580001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006580002.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006580003.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006580004.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580004.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006580005.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580005.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006580006.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580006.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006580007.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580007.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006580008.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580008.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006580009.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t006580009.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006584001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	InterPro
NV2t006584001.1	biological_process	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	"A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136]	OMA
NV2t006584001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t006584001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t006584001.1	molecular_function	GO:0005504	fatty acid binding	"Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]	OMA
NV2t006584001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t006584001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t006584001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t006584001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t006584001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t006585001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t006586001.1	biological_process	GO:0048562	embryonic organ morphogenesis	"Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t006586001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t006586001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t006586001.1	biological_process	GO:0090596	sensory organ morphogenesis	"Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]	OMA
NV2t006586001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006586002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t006586002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006586003.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t006586003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006587001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t006587001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t006587001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t006587001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	PANTHER
NV2t006587001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006587001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006587001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t006587001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006587001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006587001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	InterPro
NV2t006587001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t006587001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t006587001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t006587001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	OMA
NV2t006587001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t006587001.1	molecular_function	GO:0034061	DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:mah]	InterPro
NV2t006588001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006588001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	PANTHER
NV2t006588001.1	molecular_function	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	InterPro
NV2t006588001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006589001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006589001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	PANTHER
NV2t006591001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t006592001.1	biological_process	GO:0035331	negative regulation of hippo signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t006592002.1	biological_process	GO:0035331	negative regulation of hippo signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t006593001.1	biological_process	GO:0035331	negative regulation of hippo signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t006593001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t006593001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006594001.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	OMA
NV2t006594001.1	biological_process	GO:0097720	calcineurin-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]	PANTHER
NV2t006594001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t006594001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t006594001.1	molecular_function	GO:0033192	calmodulin-dependent protein phosphatase activity	"Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118]	OMA
NV2t006597001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006599001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006599001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006599002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006599002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006599002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t006599003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006599003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006599003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t006602001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t006602001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t006602001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t006602001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006602001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t006603001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t006607001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t006607001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t006607001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006607001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t006608001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006608001.1	molecular_function	GO:0070888	E-box binding	"Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799]	PANTHER
NV2t006610001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t006610001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t006610001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006610001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t006610001.1	molecular_function	GO:0070888	E-box binding	"Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799]	PANTHER
NV2t006611001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t006611001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006611001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t006611001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t006611001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t006611001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006611001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t006612001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006612001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006613001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t006613001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t006613001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t006613001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t006614001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t006614001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t006614001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006614001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006614001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006614001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t006614001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t006614001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t006614001.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t006614001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t006614001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t006614001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t006616001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t006616001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t006616001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t006616001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006616001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006616001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t006616001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t006616001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t006616001.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t006616001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t006616001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t006616001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t006616002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t006616002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006616003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t006616003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006620001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t006620001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006620001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t006620001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t006620001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t006620001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006620001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t006621001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t006621001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	PANTHER
NV2t006621001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t006621002.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	PANTHER
NV2t006622001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t006622001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006623001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006623001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t006623001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t006626001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006626001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t006626001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006626001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t006626001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t006627001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006627001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	PANTHER
NV2t006628001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t006628001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t006628001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006628001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006628001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t006630001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006630001.1	biological_process	GO:0006349	obsolete regulation of gene expression by genomic imprinting	"OBSOLETE. An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles." [PMID:11498578, PMID:31896690, PMID:7502071]	OMA
NV2t006630001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t006630001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006630001.1	biological_process	GO:0051052	regulation of DNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	OMA
NV2t006630001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t006630001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006630001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t006630001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006630001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006630001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006630001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006630001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t006630001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t006630001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t006630001.1	molecular_function	GO:0140682	FAD-dependent H3K4me/H3K4me3 demethylase activity	"Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction." [PMID:22473470]	OMA
NV2t006632001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t006632001.1	biological_process	GO:0006685	sphingomyelin catabolic process	"The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732]	InterPro
NV2t006632001.1	biological_process	GO:0030149	sphingolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t006632001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t006632001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t006632001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t006632001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t006632001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t006632001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t006633001.1	biological_process	GO:0016539	intein-mediated protein splicing	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]	InterPro
NV2t006633001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t006633001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006633001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t006633001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t006633001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006633001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t006633001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t006634001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006634001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006634001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006634001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006637001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t006637001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t006637001.1	cellular_component	GO:0070449	elongin complex	"A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." [PMID:12676794]	InterPro
NV2t006637001.1	cellular_component	GO:0070449	elongin complex	"A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." [PMID:12676794]	OMA
NV2t006638001.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	OMA
NV2t006638001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t006638001.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t006638001.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	OMA
NV2t006639001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t006642001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t006642001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t006642001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t006642001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006642001.1	cellular_component	GO:0061695	transferase complex, transferring phosphorus-containing groups	"A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph]	OMA
NV2t006642001.1	molecular_function	GO:0003872	6-phosphofructokinase activity	"Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11]	OMA
NV2t006642001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006642001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t006642001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t006642001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t006642001.1	molecular_function	GO:0070095	fructose-6-phosphate binding	"Binding to fructose 6-phosphate." [GOC:mah]	PANTHER
NV2t006642002.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t006642002.1	molecular_function	GO:0070095	fructose-6-phosphate binding	"Binding to fructose 6-phosphate." [GOC:mah]	PANTHER
NV2t006642003.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t006642003.1	molecular_function	GO:0070095	fructose-6-phosphate binding	"Binding to fructose 6-phosphate." [GOC:mah]	PANTHER
NV2t006643001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t006643001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006646001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t006646001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006646001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t006646001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t006647001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006647001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006647002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006647002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006649001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t006649001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t006649001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006649001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	OMA
NV2t006651001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t006651001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t006651001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t006651001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t006651001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t006652001.1	biological_process	GO:0001522	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule." [GOC:hjd, GOC:mah]	OMA
NV2t006652001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t006652001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t006652001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t006652001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t006652001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t006654001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006654001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006656001.1	biological_process	GO:0007062	sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194]	OMA
NV2t006656001.1	biological_process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	"The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]	PANTHER
NV2t006656001.1	cellular_component	GO:0008278	cohesin complex	"A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]	OMA
NV2t006656001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006656002.1	biological_process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	"The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]	PANTHER
NV2t006656002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006657001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t006658001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t006658001.1	biological_process	GO:0030149	sphingolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t006658001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t006658001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t006658001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t006658001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t006659001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	PANTHER
NV2t006661001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t006667001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t006667001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006667002.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t006667002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t006667002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006667003.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t006667003.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t006667003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006667004.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t006667004.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006667004.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t006667004.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t006667004.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t006667004.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006667004.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t006668001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t006668001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006668002.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t006668002.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006668002.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t006668002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t006668002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t006668002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t006668002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t006670001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t006670001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t006670001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t006671001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	InterPro
NV2t006671001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t006672001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t006672001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t006672001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	InterPro
NV2t006672001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t006672001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t006672001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t006674001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006674001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t006675001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t006675001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006675001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t006675001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t006675001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t006675001.1	molecular_function	GO:0070012	oligopeptidase activity	"Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t006676001.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676002.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676003.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676005.1	biological_process	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	OMA
NV2t006676005.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006676005.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t006676005.1	biological_process	GO:0050727	regulation of inflammatory response	"Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]	OMA
NV2t006676005.1	biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]	OMA
NV2t006676005.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	OMA
NV2t006676005.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676005.1	molecular_function	GO:0051019	mitogen-activated protein kinase binding	"Binding to a mitogen-activated protein kinase." [GOC:ai]	OMA
NV2t006676006.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676007.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676008.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676009.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676010.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006676011.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t006680001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	PANTHER
NV2t006681001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006681001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t006681001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006683001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t006683001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t006683001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t006683001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006683001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006683002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006683003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t006683003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006683004.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t006683004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006686001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t006686001.1	biological_process	GO:0033490	cholesterol biosynthetic process via lathosterol	"The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341]	PANTHER
NV2t006686001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006686001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006686001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t006690002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006690002.1	biological_process	GO:1904947	folate import into mitochondrion	"The process in which folic acid is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890]	PANTHER
NV2t006690003.1	biological_process	GO:1904947	folate import into mitochondrion	"The process in which folic acid is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890]	PANTHER
NV2t006690004.1	biological_process	GO:0006835	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t006690004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006690004.1	biological_process	GO:1904947	folate import into mitochondrion	"The process in which folic acid is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890]	PANTHER
NV2t006690004.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t006690004.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t006690004.1	molecular_function	GO:0015215	nucleotide transmembrane transporter activity	"Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t006690004.1	molecular_function	GO:0042887	amide transmembrane transporter activity	"Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]	OMA
NV2t006690004.1	molecular_function	GO:0046943	carboxylic acid transmembrane transporter activity	"Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]	OMA
NV2t006690004.1	molecular_function	GO:0072349	modified amino acid transmembrane transporter activity	"Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah]	OMA
NV2t006690004.1	molecular_function	GO:0090482	vitamin transmembrane transporter activity	"Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb]	OMA
NV2t006690005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006690005.1	biological_process	GO:1904947	folate import into mitochondrion	"The process in which folic acid is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890]	PANTHER
NV2t006695001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t006695001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t006695001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t006695001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006695001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t006697001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t006698001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t006699001.1	biological_process	GO:0051503	adenine nucleotide transport	"The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t006699001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006699001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t006699002.1	biological_process	GO:0051503	adenine nucleotide transport	"The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t006699002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006699002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t006699002.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t006699002.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t006699003.1	biological_process	GO:0051503	adenine nucleotide transport	"The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t006699003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006699003.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t006699004.1	biological_process	GO:0051503	adenine nucleotide transport	"The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t006699004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006699004.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t006701001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t006701001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t006701001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t006701001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	OMA
NV2t006701001.1	biological_process	GO:1902975	mitotic DNA replication initiation	"Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]	PANTHER
NV2t006701001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006701001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	InterPro
NV2t006701001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	OMA
NV2t006701001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006701001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006701001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t006703001.1	biological_process	GO:0045835	negative regulation of meiotic nuclear division	"Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]	InterPro
NV2t006703001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006704001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t006704001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t006704001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006707001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006707001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t006707001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006707001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006707001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t006707001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t006709001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t006709001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006709001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006713001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006713001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006713001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006714001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t006714001.1	biological_process	GO:0007007	inner mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t006714001.1	biological_process	GO:0045039	protein insertion into mitochondrial inner membrane	"The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." [GOC:mcc, GOC:vw, PMID:18672008]	PANTHER
NV2t006714001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	OMA
NV2t006714001.1	biological_process	GO:0090151	establishment of protein localization to mitochondrial membrane	"The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t006714001.1	cellular_component	GO:0042721	TIM22 mitochondrial import inner membrane insertion complex	"A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12." [PMID:12191765, PMID:27554484]	InterPro
NV2t006714001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t006715001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t006715002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006715002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t006715003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t006716001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t006716002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t006716002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006716003.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t006716003.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t006716003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006716003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t006722001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t006722001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t006722001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t006722001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006722001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t006725001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006725001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006725001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006725001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006729001.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	OMA
NV2t006729001.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t006748001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t006749001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t006749002.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t006749003.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t006752001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006752001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006752001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006753001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006753001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006753001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006754001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006754002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006754003.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006755001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006755001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006755001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006758001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006758001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t006758001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t006758001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006760001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006760002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006761001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t006764001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006764001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006764001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006767001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006767001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t006767001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006767001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t006767001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006767002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006767002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006767003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006767003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006768001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006768001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006770001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006770001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t006771001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t006771001.1	biological_process	GO:0006509	membrane protein ectodomain proteolysis	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]	OMA
NV2t006771001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t006771001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t006771001.1	biological_process	GO:0007220	Notch receptor processing	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]	OMA
NV2t006771001.1	biological_process	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t006771001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t006771001.1	biological_process	GO:0010941	obsolete regulation of cell death	"OBSOLETE. Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]	OMA
NV2t006771001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t006771001.1	biological_process	GO:0040008	regulation of growth	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]	OMA
NV2t006771001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t006771001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t006771001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t006771001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006771001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t006771001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t006771002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t006771002.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t006771002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t006771003.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t006773001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006773001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006773001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t006773001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006774001.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t006774001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t006774002.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t006774002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t006775001.1	biological_process	GO:0015850	organic hydroxy compound transport	"The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]	OMA
NV2t006775001.1	biological_process	GO:0046865	terpenoid transport	"The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai]	OMA
NV2t006775001.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t006775001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t006775001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t006775001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t006775001.1	molecular_function	GO:0090482	vitamin transmembrane transporter activity	"Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb]	OMA
NV2t006775001.1	molecular_function	GO:1901618	organic hydroxy compound transmembrane transporter activity	"Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t006775002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t006775003.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t006775003.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t006777001.1	biological_process	GO:0006403	RNA localization	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t006777001.1	biological_process	GO:0019953	sexual reproduction	"A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction]	OMA
NV2t006777001.1	biological_process	GO:0022414	reproductive process	"A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]	OMA
NV2t006777001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t006777001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t006777001.1	biological_process	GO:0051347	positive regulation of transferase activity	"Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]	OMA
NV2t006777001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t006777001.1	biological_process	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t006777001.1	biological_process	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	OMA
NV2t006777001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t006777001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t006777001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006777001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t006777001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t006777001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006777001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006777001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t006777001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t006777001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t006777001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t006777001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t006777001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t006780001.1	biological_process	GO:0006805	xenobiotic metabolic process	"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc]	OMA
NV2t006780001.1	biological_process	GO:0009404	toxin metabolic process	"The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2]	OMA
NV2t006780001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t006780001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t006780001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t006780001.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	OMA
NV2t006780001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006780001.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t006780001.1	cellular_component	GO:0035657	eRF1 methyltransferase complex	"A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p." [GOC:rb, PMID:17008308, PMID:20400505]	PANTHER
NV2t006780001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006780001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006780001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t006780001.1	molecular_function	GO:0009008	DNA-methyltransferase activity	"Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732, PMID:7862522]	OMA
NV2t006780001.1	molecular_function	GO:0018024	obsolete histone lysine N-methyltransferase activity	"OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [RHEA:10024]	OMA
NV2t006780001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t006780001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t006786001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006786001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t006786001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t006786001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t006786001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t006786002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006786002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t006786003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006786003.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t006786004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006786004.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t006788001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t006791001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006791001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006796001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t006796001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t006796001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t006798001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t006800001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006800001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t006800002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006800002.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t006800003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006800003.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t006800004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006800004.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t006802001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006802001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t006802001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t006803001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t006803001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t006806001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006807001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006807001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t006807001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t006807001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006807001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006808001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t006809001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006809001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t006809001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006809001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006810001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006810001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006811001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t006812001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006816001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t006816001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t006816001.1	biological_process	GO:0007080	mitotic metaphase chromosome alignment	"A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [ISBN:0815316194]	OMA
NV2t006816001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006816001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t006816001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t006816001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006816001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t006816001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t006816001.1	molecular_function	GO:0008574	plus-end-directed microtubule motor activity	"A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis." [GOC:vw, PMID:32842864]	OMA
NV2t006816002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t006816002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t006819001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006819001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006819001.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	PANTHER
NV2t006819002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t006819002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t006819002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006821001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t006821001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t006821001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t006821001.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t006821001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t006821001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006821001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006821001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t006821001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t006821001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t006821001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t006823001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t006823001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006824001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t006824001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t006824001.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	OMA
NV2t006824001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	PANTHER
NV2t006824001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	OMA
NV2t006824001.1	biological_process	GO:1902017	regulation of cilium assembly	"Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]	OMA
NV2t006824001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t006824001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t006824001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t006824001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006824001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t006824001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t006824001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006825001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006825001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t006825001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t006825001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006825001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006825001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t006827001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006827001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006827001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006827001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t006828001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006828001.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t006830001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t006830001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006830001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t006831001.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	InterPro
NV2t006831001.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	PANTHER
NV2t006831002.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	InterPro
NV2t006831002.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	PANTHER
NV2t006832002.1	molecular_function	GO:0008276	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]	PANTHER
NV2t006832003.1	molecular_function	GO:0008276	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]	OMA
NV2t006832003.1	molecular_function	GO:0008276	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]	PANTHER
NV2t006832004.1	molecular_function	GO:0008276	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]	PANTHER
NV2t006833001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006833001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006833001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006833001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t006834001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t006837001.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	OMA
NV2t006837001.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	PANTHER
NV2t006837001.1	biological_process	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	OMA
NV2t006837001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006837001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006837001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006837001.1	molecular_function	GO:0018024	obsolete histone lysine N-methyltransferase activity	"OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [RHEA:10024]	OMA
NV2t006837001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t006838001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t006838001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006838001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006838001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006838001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t006838001.1	molecular_function	GO:0005432	calcium:sodium antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]	OMA
NV2t006839001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006839001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t006839001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t006845001.1	biological_process	GO:0045879	negative regulation of smoothened signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t006845001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t006845001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t006845001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t006845001.1	cellular_component	GO:0060170	ciliary membrane	"The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph]	PANTHER
NV2t006845001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t006846001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t006846001.1	biological_process	GO:0045664	regulation of neuron differentiation	"Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]	OMA
NV2t006846001.1	biological_process	GO:0045879	negative regulation of smoothened signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t006846001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t006846001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t006846001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t006846001.1	cellular_component	GO:0060170	ciliary membrane	"The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph]	PANTHER
NV2t006846001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t006847001.1	biological_process	GO:0006473	protein acetylation	"The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t006847001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t006847001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t006847001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t006849001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006849001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006849001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t006850001.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	PANTHER
NV2t006852001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t006852001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t006852001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t006852001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t006852001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t006852001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t006853001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t006855001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t006855001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t006855001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t006855001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006855001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t006855001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006855001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t006855001.1	molecular_function	GO:0050353	trimethyllysine dioxygenase activity	"Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate." [EC:1.14.11.8, RHEA:14181]	InterPro
NV2t006856001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t006856001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006857001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t006857001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t006857002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t006857003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t006858001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006858002.1	biological_process	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]	OMA
NV2t006858002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006858002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006858002.1	biological_process	GO:2000036	regulation of stem cell population maintenance	"Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol]	OMA
NV2t006858002.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t006858002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006858002.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	OMA
NV2t006858002.1	cellular_component	GO:0030015	CCR4-NOT core complex	"The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136]	InterPro
NV2t006858002.1	cellular_component	GO:0030015	CCR4-NOT core complex	"The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136]	PANTHER
NV2t006858002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006858003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006858003.1	cellular_component	GO:0030015	CCR4-NOT core complex	"The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136]	InterPro
NV2t006858003.1	cellular_component	GO:0030015	CCR4-NOT core complex	"The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136]	PANTHER
NV2t006859001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t006859001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t006859001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t006859001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t006859001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006859001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t006859001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t006861001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t006861001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t006870001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006870001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006870001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006870001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t006870001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t006871001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006871001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006871001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t006872001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t006872001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t006872001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t006872001.1	biological_process	GO:0010256	endomembrane system organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm]	OMA
NV2t006872001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t006872001.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t006872001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t006872001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t006872001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t006872001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t006872001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t006872001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006874001.1	biological_process	GO:0018193	peptidyl-amino acid modification	"The alteration of an amino acid residue in a peptide." [GOC:mah]	OMA
NV2t006874001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006874001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006874001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t006874001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t006874001.1	molecular_function	GO:0008276	protein methyltransferase activity	"Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl]	OMA
NV2t006874001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t006875001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t006875001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t006875001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	PANTHER
NV2t006875001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t006875001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	OMA
NV2t006875001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t006875001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006875001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t006875001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t006875001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t006875002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t006875002.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	PANTHER
NV2t006875002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006876001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t006876001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t006876001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t006876001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t006876001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t006876001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t006877001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t006877001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t006878001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t006878001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t006878001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t006878001.1	biological_process	GO:1901096	regulation of autophagosome maturation	"Any process that modulates the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]	PANTHER
NV2t006878001.1	biological_process	GO:1901097	negative regulation of autophagosome maturation	"Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]	OMA
NV2t006878001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t006878001.1	biological_process	GO:1904766	obsolete negative regulation of macroautophagy by TORC1 signaling	"OBSOLETE. A TORC1 signaling that results in negative regulation of macroautophagy." [GO_REF:0000063, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:23602450]	OMA
NV2t006878001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t006878001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t006878001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006878001.1	cellular_component	GO:0036020	endolysosome membrane	"The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]	OMA
NV2t006880001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t006881001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t006883001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t006883001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006883001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t006884001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t006884002.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t006884002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006884003.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t006884003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006884003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t006884004.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t006884004.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006885001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t006885001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006888001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t006888001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006888001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t006888001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t006888001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006888001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t006892001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t006892001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006892002.1	biological_process	GO:0001754	eye photoreceptor cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]	OMA
NV2t006892002.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t006892002.1	biological_process	GO:0007416	synapse assembly	"The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah]	OMA
NV2t006892002.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t006892002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t006892002.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t006892002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006892003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t006892003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006892004.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t006892004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006894001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t006894001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006894002.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t006894002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006895001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t006895001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	OMA
NV2t006895001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006895001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t006895001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t006895001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t006895001.1	molecular_function	GO:0015269	calcium-activated potassium channel activity	"Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	OMA
NV2t006895001.1	molecular_function	GO:0051371	muscle alpha-actinin binding	"Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165]	OMA
NV2t006897001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006897002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t006897002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t006899001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006900001.1	cellular_component	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	PANTHER
NV2t006901001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006901001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t006901001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t006902001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006902001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t006902002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006902003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006902004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006903001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006904001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t006904001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t006904001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t006904001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t006906001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006906002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t006908001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t006908001.1	biological_process	GO:0032370	positive regulation of lipid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t006908001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t006908001.1	biological_process	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	OMA
NV2t006908001.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t006908001.1	biological_process	GO:0046471	phosphatidylglycerol metabolic process	"The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t006908001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t006908001.1	biological_process	GO:0051171	obsolete regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t006908001.1	biological_process	GO:0060541	respiratory system development	"The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]	OMA
NV2t006908001.1	biological_process	GO:0070925	organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t006908001.1	biological_process	GO:0140352	export from cell	"The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg]	OMA
NV2t006908001.1	biological_process	GO:0140962	multicellular organismal-level chemical homeostasis	"A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:curators]	OMA
NV2t006908001.1	biological_process	GO:1903725	regulation of phospholipid metabolic process	"Any process that modulates the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]	OMA
NV2t006908001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t006908001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006908001.1	cellular_component	GO:0030667	secretory granule membrane	"The lipid bilayer surrounding a secretory granule." [GOC:mah]	OMA
NV2t006908001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t006908001.1	molecular_function	GO:0008525	phosphatidylcholine transporter activity	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]	OMA
NV2t006908001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t006908001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t006908001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t006908001.1	molecular_function	GO:0120014	phospholipid transfer activity	"Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t006908001.1	molecular_function	GO:0140303	intramembrane lipid transporter activity	"Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084]	OMA
NV2t006908001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t006910001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t006912001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t006914001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t006914001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t006914001.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t006914001.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t006914001.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t006914001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t006919001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006919002.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	OMA
NV2t006919002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006919002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006919002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006920001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t006920001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006921001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t006921001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t006921001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t006921001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t006921001.1	cellular_component	GO:0030686	90S preribosome	"A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]	PANTHER
NV2t006921001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t006921001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006923001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t006923001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006923001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006923001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t006923001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t006927001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t006927001.1	molecular_function	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222]	PANTHER
NV2t006928001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t006928001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t006928001.1	molecular_function	GO:0008192	RNA guanylyltransferase activity	"Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah]	OMA
NV2t006928001.1	molecular_function	GO:0008193	tRNA guanylyltransferase activity	"Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461]	InterPro
NV2t006928001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t006929001.1	biological_process	GO:0099041	vesicle tethering to Golgi	"The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion." [PMID:27243008]	InterPro
NV2t006933001.1	biological_process	GO:0016036	cellular response to phosphate starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl]	PANTHER
NV2t006933001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006934001.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	OMA
NV2t006934001.1	biological_process	GO:0006479	protein methylation	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]	OMA
NV2t006934001.1	biological_process	GO:0043244	regulation of protein-containing complex disassembly	"Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]	OMA
NV2t006934001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006934001.1	cellular_component	GO:0018444	translation release factor complex	"A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]	PANTHER
NV2t006934001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t006934001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t006934001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t006934001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t006934001.1	molecular_function	GO:0008135	translation factor activity, RNA binding	"Functions during translation by binding to RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw]	OMA
NV2t006935001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t006935001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t006935001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t006935001.1	molecular_function	GO:0003994	aconitate hydratase activity	"Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw]	OMA
NV2t006935001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t006935001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t006935001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t006935002.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t006935002.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t006935003.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t006935003.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t006938001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006938001.1	molecular_function	GO:0030332	cyclin binding	"Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]	OMA
NV2t006938001.1	molecular_function	GO:0030332	cyclin binding	"Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]	PANTHER
NV2t006944001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t006944001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006947001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t006947001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t006948001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006948001.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t006948001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006948002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006948002.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t006948003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006948003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006948004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t006948004.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t006948004.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t006949001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t006949001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t006950001.1	biological_process	GO:0006760	folic acid-containing compound metabolic process	"The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah]	OMA
NV2t006950001.1	biological_process	GO:0046900	tetrahydrofolylpolyglutamate metabolic process	"The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t006950001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t006950001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t006950001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	InterPro
NV2t006950001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t006950001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t006953001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t006953001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t006955001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t006955001.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	InterPro
NV2t006955001.1	biological_process	GO:0046390	ribose phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	OMA
NV2t006955001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006955001.1	cellular_component	GO:0061695	transferase complex, transferring phosphorus-containing groups	"A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph]	OMA
NV2t006955001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t006955001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t006956001.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t006956001.1	molecular_function	GO:0070095	fructose-6-phosphate binding	"Binding to fructose 6-phosphate." [GOC:mah]	PANTHER
NV2t006958001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t006958001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006958002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t006958002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t006958002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006958002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006958002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006960001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t006963001.1	molecular_function	GO:0008119	thiopurine S-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]	PANTHER
NV2t006963001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t006964001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006965001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006966001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006966001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t006966001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t006966001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t006966001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006966001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006966001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t006969001.1	biological_process	GO:0006576	biogenic amine metabolic process	"The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]	OMA
NV2t006969001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t006969001.1	biological_process	GO:0034308	primary alcohol metabolic process	"The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]	OMA
NV2t006969001.1	biological_process	GO:0070291	N-acylethanolamine metabolic process	"The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group." [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693]	PANTHER
NV2t006969001.1	biological_process	GO:1901160	primary amino compound metabolic process	"The chemical reactions and pathways involving primary amino compound." [GOC:TermGenie]	OMA
NV2t006969001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006969001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t006969001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t006970001.1	biological_process	GO:0006549	isoleucine metabolic process	"The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	OMA
NV2t006970001.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t006970001.1	biological_process	GO:0009068	aspartate family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t006970001.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t006970001.1	biological_process	GO:1901607	alpha-amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t006970001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t006970001.1	molecular_function	GO:0016840	carbon-nitrogen lyase activity	"Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]	OMA
NV2t006971001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t006971002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t006972001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t006972001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t006972001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006972001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t006975001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t006977001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t006977001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t006977001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t006977001.1	biological_process	GO:0038202	TORC1 signaling	"A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]	OMA
NV2t006977001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t006977001.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t006977001.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	PANTHER
NV2t006977001.1	cellular_component	GO:0000323	lytic vacuole	"A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]	OMA
NV2t006977001.1	cellular_component	GO:0031931	TORC1 complex	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t006977001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006977001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006977001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t006981001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t006981002.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t006981003.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t006984001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t006984001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t006986001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t006986001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t006986001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t006986001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t006986001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	OMA
NV2t006986001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006987001.1	biological_process	GO:0006275	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	OMA
NV2t006987001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t006987001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t006987001.1	biological_process	GO:0033044	regulation of chromosome organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]	OMA
NV2t006987001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t006987001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t006987001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t006987001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	OMA
NV2t006987001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	PANTHER
NV2t006988001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t006988001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t006988001.1	biological_process	GO:0002832	negative regulation of response to biotic stimulus	"Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]	OMA
NV2t006988001.1	biological_process	GO:0006497	protein lipidation	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]	OMA
NV2t006988001.1	biological_process	GO:0018410	C-terminal protein amino acid modification	"The alteration of the C-terminal amino acid residue in a protein." [GOC:mah]	OMA
NV2t006988001.1	biological_process	GO:0031348	negative regulation of defense response	"Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah]	OMA
NV2t006988001.1	biological_process	GO:0032102	negative regulation of response to external stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t006988001.1	biological_process	GO:0044804	nucleophagy	"A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549]	PANTHER
NV2t006988001.1	biological_process	GO:0048524	positive regulation of viral process	"Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]	OMA
NV2t006988001.1	biological_process	GO:0050688	regulation of defense response to virus	"Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]	OMA
NV2t006988001.1	biological_process	GO:1901096	regulation of autophagosome maturation	"Any process that modulates the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]	OMA
NV2t006988001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t006988001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t006988001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t006988001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t006988001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t006988001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t006991001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t006991001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006992001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t006992001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t006992001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t006993001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t006993001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t006994001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t006994001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t006994001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t006994001.1	molecular_function	GO:0008273	calcium, potassium:sodium antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1]	OMA
NV2t006996001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t006996001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t006996001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t006996001.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	OMA
NV2t006996001.1	cellular_component	GO:0044599	AP-5 adaptor complex	"An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo." [PMID:22022230]	InterPro
NV2t006998001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006998001.1	molecular_function	GO:0043531	ADP binding	"Binding to ADP, adenosine 5'-diphosphate." [GOC:jl]	InterPro
NV2t006998001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t006998002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t006998002.1	molecular_function	GO:0043531	ADP binding	"Binding to ADP, adenosine 5'-diphosphate." [GOC:jl]	InterPro
NV2t006998002.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t006999001.1	biological_process	GO:0036503	ERAD pathway	"The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]	OMA
NV2t006999001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t006999001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007000001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007001001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t007002001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t007002001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007002001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007002002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t007002002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007002002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007002003.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t007002003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007002003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007002004.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t007002004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007002004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007003001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007003001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t007003001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t007004001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t007009001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007011001.1	biological_process	GO:0006760	folic acid-containing compound metabolic process	"The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah]	OMA
NV2t007011001.1	biological_process	GO:0046900	tetrahydrofolylpolyglutamate metabolic process	"The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t007011001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t007011001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t007011001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	InterPro
NV2t007011001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t007011001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007012001.1	biological_process	GO:0006760	folic acid-containing compound metabolic process	"The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah]	OMA
NV2t007012001.1	biological_process	GO:0046900	tetrahydrofolylpolyglutamate metabolic process	"The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t007012001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t007012001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007012001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t007012001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007012001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t007012001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	InterPro
NV2t007012001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t007012001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007013001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007013001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007016001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t007016001.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t007016001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t007016001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t007016001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007016001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007016001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t007016001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t007016001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t007016001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t007017001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t007017001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007017001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007017001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007017001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t007017001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t007017001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t007017001.1	molecular_function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	"Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t007017001.1	molecular_function	GO:1902936	phosphatidylinositol bisphosphate binding	"Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]	InterPro
NV2t007017001.1	molecular_function	GO:1902936	phosphatidylinositol bisphosphate binding	"Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]	OMA
NV2t007020001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t007020001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007020001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t007020002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007021001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t007021002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t007022001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007023002.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	InterPro
NV2t007024001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007027001.1	biological_process	GO:0015914	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	InterPro
NV2t007027001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t007027002.1	biological_process	GO:0015914	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	InterPro
NV2t007027002.1	molecular_function	GO:0005548	phospholipid transporter activity	"Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732]	OMA
NV2t007027002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t007027003.1	biological_process	GO:0015914	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	InterPro
NV2t007027003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t007029001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007029001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t007031001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007031001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007031001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t007031001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007031001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007031001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t007033001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007033001.1	biological_process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]	OMA
NV2t007033001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	InterPro
NV2t007033001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t007033001.1	biological_process	GO:0010922	positive regulation of phosphatase activity	"Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t007033001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t007033001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t007033001.1	biological_process	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	OMA
NV2t007033001.1	biological_process	GO:0032006	regulation of TOR signaling	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t007033001.1	biological_process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t007033001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	OMA
NV2t007033001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t007033001.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t007033001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t007033001.1	cellular_component	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	OMA
NV2t007033001.1	cellular_component	GO:0016328	lateral plasma membrane	"The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]	OMA
NV2t007033001.1	cellular_component	GO:0031526	brush border membrane	"The portion of the plasma membrane surrounding the brush border." [GOC:mah]	OMA
NV2t007033001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t007033001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t007033001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t007033001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t007033001.1	molecular_function	GO:0019001	guanyl nucleotide binding	"Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t007033001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t007033001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t007033001.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t007033001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t007033002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007033002.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	InterPro
NV2t007033002.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t007034001.1	molecular_function	GO:0004416	hydroxyacylglutathione hydrolase activity	"Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6]	PANTHER
NV2t007035001.1	biological_process	GO:0006361	transcription initiation at RNA polymerase I promoter	"A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I." [GOC:txnOH]	InterPro
NV2t007037001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	PANTHER
NV2t007037001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007037002.1	biological_process	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	OMA
NV2t007037002.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t007037002.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	PANTHER
NV2t007037002.1	biological_process	GO:0035272	exocrine system development	"Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, Wikipedia:Exocrine_gland]	OMA
NV2t007037002.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	OMA
NV2t007037002.1	biological_process	GO:0045055	regulated exocytosis	"A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]	OMA
NV2t007037002.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t007037002.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t007037002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007037002.1	cellular_component	GO:0030667	secretory granule membrane	"The lipid bilayer surrounding a secretory granule." [GOC:mah]	OMA
NV2t007037002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t007037002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007037002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007037003.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	PANTHER
NV2t007037003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007038001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t007039001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007039001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007039001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007042001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007042001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007043001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007043001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007045001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007045001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007046001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t007046001.1	biological_process	GO:0009226	nucleotide-sugar biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]	OMA
NV2t007046001.1	biological_process	GO:0009298	GDP-mannose biosynthetic process	"The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	InterPro
NV2t007046001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t007046001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007046001.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t007047001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007047001.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t007047001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t007049001.1	biological_process	GO:0009298	GDP-mannose biosynthetic process	"The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	InterPro
NV2t007050001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007050001.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t007050001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t007050001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t007050001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t007052001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007055001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t007055001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	InterPro
NV2t007055001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t007055002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	InterPro
NV2t007057001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t007057001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007058001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t007063001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t007063001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007063001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007064001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007064001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t007066001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t007066001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007068001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	PANTHER
NV2t007069001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t007069001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007069001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007069001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007069001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t007069001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t007069001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t007071001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007071001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007071001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007071001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t007073001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t007075001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t007075001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t007075001.1	molecular_function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai]	InterPro
NV2t007076001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007076001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t007077001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t007077001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007077001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007077001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t007077001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t007077001.1	biological_process	GO:1990403	embryonic brain development	"The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure." [PMID:15918910]	OMA
NV2t007077001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007077001.1	cellular_component	GO:0005790	smooth endoplasmic reticulum	"The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732]	OMA
NV2t007077001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t007077001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007077001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t007077001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t007077001.1	molecular_function	GO:0045182	translation regulator activity	"Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]	OMA
NV2t007079001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t007079001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t007079001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007079001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t007079001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t007080001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t007080001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007080001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t007080001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007080001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007080001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t007082001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007082002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007082003.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007083001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007085001.1	molecular_function	GO:0071209	U7 snRNA binding	"Binding to a U7 small nuclear RNA (U7 snRNA)." [GOC:mah, PMID:12975319]	InterPro
NV2t007086001.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t007086001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t007086001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t007086001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t007086001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t007086001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007086001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t007086001.1	molecular_function	GO:0120170	intraciliary transport particle B binding	"Binding to an intraciliary transport particle B (IFT B) complex." [PMID:20889716]	PANTHER
NV2t007089001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t007089001.1	biological_process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t007089001.1	biological_process	GO:0050909	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai]	OMA
NV2t007089001.1	cellular_component	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	OMA
NV2t007089001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007089001.1	molecular_function	GO:0031681	G-protein beta-subunit binding	"Binding to a G-protein beta subunit." [GOC:mah]	InterPro
NV2t007089001.1	molecular_function	GO:0031681	G-protein beta-subunit binding	"Binding to a G-protein beta subunit." [GOC:mah]	PANTHER
NV2t007092001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t007092001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t007092001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	PANTHER
NV2t007092001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t007092001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	InterPro
NV2t007092001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	OMA
NV2t007092001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t007093001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t007093001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t007093001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t007093001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t007093001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t007093001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t007093001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t007093001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007093001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t007093001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t007093001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t007094001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t007094001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t007094001.1	cellular_component	GO:0035658	Mon1-Ccz1 complex	"A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862]	OMA
NV2t007094001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t007095001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	InterPro
NV2t007095001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t007095001.1	cellular_component	GO:0000145	exocyst	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]	OMA
NV2t007095001.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t007097001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007098001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t007103001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t007103002.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t007103003.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t007103004.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t007104001.1	biological_process	GO:0006621	protein retention in ER lumen	"The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]	OMA
NV2t007104001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t007104001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t007104001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t007104001.1	cellular_component	GO:0005801	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	OMA
NV2t007104001.1	cellular_component	GO:0030663	COPI-coated vesicle membrane	"The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah]	OMA
NV2t007104001.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t007104001.1	molecular_function	GO:0046923	ER retention sequence binding	"Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai]	InterPro
NV2t007105001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007105001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007105002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007105002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007105002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007105002.1	molecular_function	GO:0015116	sulfate transmembrane transporter activity	"Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]	OMA
NV2t007105003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007105003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007107001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t007107001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007107001.1	biological_process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	"Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb]	OMA
NV2t007107001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t007107001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t007107001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t007107001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007107001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t007107001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t007107001.1	molecular_function	GO:0019838	growth factor binding	"Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators]	OMA
NV2t007107001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t007108001.1	biological_process	GO:0050708	regulation of protein secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	PANTHER
NV2t007108001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007108001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t007109001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007109002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007109003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007110001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t007110001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t007110001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t007110001.1	biological_process	GO:0036503	ERAD pathway	"The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]	OMA
NV2t007110001.1	biological_process	GO:0045048	protein insertion into ER membrane	"The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]	InterPro
NV2t007110001.1	biological_process	GO:0051220	cytoplasmic sequestering of protein	"The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai]	OMA
NV2t007110001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t007110001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	OMA
NV2t007110001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t007110001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007110001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t007110001.1	cellular_component	GO:0071818	BAT3 complex	"A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303]	PANTHER
NV2t007110001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007110001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t007110002.1	biological_process	GO:0045048	protein insertion into ER membrane	"The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]	InterPro
NV2t007110002.1	cellular_component	GO:0071818	BAT3 complex	"A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303]	PANTHER
NV2t007110002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007110003.1	cellular_component	GO:0071818	BAT3 complex	"A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303]	PANTHER
NV2t007110003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007111001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007111001.1	molecular_function	GO:0061685	diphthine methylesterase activity	"Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42656]	PANTHER
NV2t007111002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007111002.1	molecular_function	GO:0061685	diphthine methylesterase activity	"Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42656]	PANTHER
NV2t007111003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007111003.1	molecular_function	GO:0061685	diphthine methylesterase activity	"Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42656]	PANTHER
NV2t007111004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007111004.1	molecular_function	GO:0061685	diphthine methylesterase activity	"Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42656]	PANTHER
NV2t007111005.1	biological_process	GO:0006448	regulation of translational elongation	"Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]	OMA
NV2t007111005.1	biological_process	GO:0018202	peptidyl-histidine modification	"The modification of peptidyl-histidine." [GOC:ma]	OMA
NV2t007111005.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t007111005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007111005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007111005.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t007111005.1	molecular_function	GO:0061685	diphthine methylesterase activity	"Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42656]	PANTHER
NV2t007112001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t007112001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t007112001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007112001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007113001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t007113001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t007113001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t007113001.1	molecular_function	GO:0004407	histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [PMID:9893272, RHEA:58196]	OMA
NV2t007114001.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	PANTHER
NV2t007114001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007114002.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	PANTHER
NV2t007114002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007114003.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	PANTHER
NV2t007114003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007114004.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	PANTHER
NV2t007114004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007114005.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	PANTHER
NV2t007114005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007116001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007116001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007116001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007116002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t007116002.1	biological_process	GO:0033209	tumor necrosis factor-mediated signaling pathway	"The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t007116002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007116002.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t007116002.1	biological_process	GO:0046330	positive regulation of JNK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	OMA
NV2t007116002.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	OMA
NV2t007116002.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t007116002.1	biological_process	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t007116002.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t007116002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007116002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007116002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007116002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t007116002.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t007116002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t007116002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007116003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007116003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007120001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t007120001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007120001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007120001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007120001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t007120001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t007120001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t007127001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007128001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t007128001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007130001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t007130001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t007130001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t007130001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t007130001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007130001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007130001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t007130002.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t007130002.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t007130002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007133001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t007133001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t007133001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t007136001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007136002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007136003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007136004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007136005.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007136006.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t007136006.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007137001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007137001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t007137001.1	biological_process	GO:0009611	response to wounding	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]	OMA
NV2t007137001.1	biological_process	GO:0010942	obsolete positive regulation of cell death	"OBSOLETE. Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]	OMA
NV2t007137001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t007137001.1	biological_process	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t007137001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t007137001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t007137001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007137001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t007137001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007137001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007137001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007137001.1	molecular_function	GO:0008545	JUN kinase kinase activity	"Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549]	OMA
NV2t007137001.1	molecular_function	GO:0008545	JUN kinase kinase activity	"Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549]	PANTHER
NV2t007138001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007138001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t007141001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t007141001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t007141001.1	biological_process	GO:0042797	tRNA transcription by RNA polymerase III	"The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t007141001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007142001.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	InterPro
NV2t007142001.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	OMA
NV2t007142001.1	molecular_function	GO:0008135	translation factor activity, RNA binding	"Functions during translation by binding to RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw]	OMA
NV2t007143001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t007143001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t007143001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t007143001.1	biological_process	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t007143001.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t007143001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007143001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007143001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t007143001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007143001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t007145001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007146001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t007146001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007146001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t007146001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007146001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t007147001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007147001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t007147001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007147001.1	molecular_function	GO:0005432	calcium:sodium antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]	OMA
NV2t007148001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t007148001.1	biological_process	GO:0032984	protein-containing complex disassembly	"The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah]	OMA
NV2t007148001.1	biological_process	GO:0035092	sperm DNA condensation	"The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001]	OMA
NV2t007148001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t007148001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007148001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007148001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007148001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t007148001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t007148001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t007151001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t007151001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t007151001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t007151001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t007151001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007151001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007151001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t007152001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t007152001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t007152001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t007152001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007152001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007152001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t007152001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007152001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007153001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t007153001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t007153001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t007153001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t007153001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007153001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007153001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t007153002.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t007153002.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t007153002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007154001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	PANTHER
NV2t007154001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007154001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007154001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t007159001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007161001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007161001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t007161001.1	cellular_component	GO:0035102	PRC1 complex	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]	OMA
NV2t007161001.1	cellular_component	GO:0035102	PRC1 complex	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]	PANTHER
NV2t007161001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t007161001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t007162001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t007162001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t007163001.1	biological_process	GO:0042780	tRNA 3'-end processing	"The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators]	OMA
NV2t007163001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t007163001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t007163001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007165001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007165001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007165001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t007165001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007166001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t007167001.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167002.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167003.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167004.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167005.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167006.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167007.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167008.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167009.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167010.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167011.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167012.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007167013.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t007169001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t007169001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t007169001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t007169001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t007169001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t007169001.1	biological_process	GO:0009411	response to UV	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]	OMA
NV2t007169001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	OMA
NV2t007169001.1	biological_process	GO:0032786	positive regulation of DNA-templated transcription, elongation	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	OMA
NV2t007169001.1	biological_process	GO:0045945	positive regulation of transcription by RNA polymerase III	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007169001.1	biological_process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	"Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]	OMA
NV2t007169001.1	biological_process	GO:2000780	negative regulation of double-strand break repair	"Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t007169001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t007169001.1	cellular_component	GO:0008023	transcription elongation factor complex	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]	OMA
NV2t007169001.1	cellular_component	GO:0070603	SWI/SNF superfamily-type complex	"A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]	OMA
NV2t007169001.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	OMA
NV2t007169001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007169001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t007169001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007169001.1	molecular_function	GO:0008022	obsolete protein C-terminus binding	"OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t007169001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	PANTHER
NV2t007169001.1	molecular_function	GO:0030296	protein tyrosine kinase activator activity	"Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732]	OMA
NV2t007169001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t007169001.1	molecular_function	GO:0047485	obsolete protein N-terminus binding	"OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t007169001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t007169001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t007170001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t007170001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t007170001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t007177001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t007178001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t007179001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t007180001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007180001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007180001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t007180001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007182001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t007182001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	PANTHER
NV2t007182001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t007182002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t007182002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t007182002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	PANTHER
NV2t007182002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007182002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t007182002.1	molecular_function	GO:0019104	DNA N-glycosylase activity	"Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]	OMA
NV2t007182003.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t007182003.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	PANTHER
NV2t007182003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t007183001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t007183001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	PANTHER
NV2t007183001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t007183002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t007183002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t007183002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	PANTHER
NV2t007183002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007183002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t007183002.1	molecular_function	GO:0019104	DNA N-glycosylase activity	"Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]	OMA
NV2t007185001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007185001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007185001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	OMA
NV2t007185001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t007185002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007185002.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t007185003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007185003.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t007185004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007185004.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t007185005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007185005.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t007186001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t007186001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007186001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007186001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t007187001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007187001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t007187001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007187001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007187002.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007188001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007192001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007193001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007193001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t007193001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007193001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007195001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007195001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t007195001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007195001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007196001.1	cellular_component	GO:0030686	90S preribosome	"A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]	PANTHER
NV2t007198001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t007198001.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	PANTHER
NV2t007198001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007198001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007198002.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t007198002.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	PANTHER
NV2t007198002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007198002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007198003.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	PANTHER
NV2t007200001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007200001.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007200001.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007200002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007200002.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007200003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007200003.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007200004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007200004.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007201001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007201001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007202001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t007202001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007202001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007202001.1	molecular_function	GO:0061656	SUMO conjugating enzyme activity	"Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph]	OMA
NV2t007202001.1	molecular_function	GO:0061656	SUMO conjugating enzyme activity	"Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph]	PANTHER
NV2t007207001.1	biological_process	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	OMA
NV2t007207001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t007207001.1	molecular_function	GO:0090729	toxin activity	"Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom." [GOC:pt]	InterPro
NV2t007210001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t007211001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007211001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007211001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t007211001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007211001.1	molecular_function	GO:1905762	CCR4-NOT complex binding	"Binding to a CCR4-NOT complex." [GOC:TermGenie, PMID:26942678]	PANTHER
NV2t007218001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t007218001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007218001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007219001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t007219001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007222001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007222001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t007223001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007223001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007223002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007223002.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007223003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007223003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t007223003.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t007223003.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t007223003.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007223003.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t007227001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007227001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t007227001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t007228001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007228001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t007230001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t007230001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t007230001.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t007230001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t007230001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t007230001.1	biological_process	GO:0046627	negative regulation of insulin receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]	OMA
NV2t007230001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t007230001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	InterPro
NV2t007230001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	OMA
NV2t007230001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t007230001.1	biological_process	GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t007230001.1	biological_process	GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	PANTHER
NV2t007230001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007230001.1	cellular_component	GO:0033596	TSC1-TSC2 complex	"A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671]	OMA
NV2t007230001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t007232001.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t007232001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t007232001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t007232001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t007232001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	OMA
NV2t007232001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t007237001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007237001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007237001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t007237002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007237002.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t007238001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007238001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t007238001.1	biological_process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	InterPro
NV2t007238001.1	molecular_function	GO:0004143	ATP-dependent diacylglycerol kinase activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+." [GOC:elh, RHEA:10272]	OMA
NV2t007238001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t007239002.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t007239002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007241001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007241001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t007243001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t007243001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t007243001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t007243002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t007243002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t007243002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t007244001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t007244001.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	InterPro
NV2t007245001.1	biological_process	GO:0006694	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	OMA
NV2t007245001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t007245001.1	molecular_function	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah]	OMA
NV2t007246001.1	biological_process	GO:0001932	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	OMA
NV2t007246001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t007246001.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t007246001.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	InterPro
NV2t007246001.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	OMA
NV2t007248001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007249001.1	biological_process	GO:0006641	triglyceride metabolic process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]	OMA
NV2t007249001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	InterPro
NV2t007249001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t007249001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t007252001.1	biological_process	GO:0006828	manganese ion transport	"The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t007252001.1	biological_process	GO:0007338	single fertilization	"The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu]	OMA
NV2t007252001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t007252001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007252001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007252001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007252001.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t007252001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007252001.1	molecular_function	GO:0015279	store-operated calcium channel activity	"A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]	OMA
NV2t007252001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t007252001.1	molecular_function	GO:0043178	alcohol binding	"Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]	OMA
NV2t007252001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t007253001.1	biological_process	GO:0070646	protein modification by small protein removal	"A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein." [GOC:mah]	PANTHER
NV2t007253001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t007253002.1	biological_process	GO:0070646	protein modification by small protein removal	"A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein." [GOC:mah]	PANTHER
NV2t007253002.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t007255001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t007255001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007255001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t007255001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007255002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007255002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t007255002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007256001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t007256001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007258001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007258001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t007259001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007259001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007259002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007259002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007260001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t007260001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t007260001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t007261001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007262001.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007262001.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007262002.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007262002.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007262003.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007262003.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007262004.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007262004.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007262005.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007262005.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263001.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263001.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263002.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263002.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263003.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263003.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263004.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263004.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263005.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263005.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263006.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263006.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263007.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263007.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	OMA
NV2t007263007.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t007263007.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263007.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t007263007.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t007263007.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t007263008.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263008.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007263009.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007263009.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007264001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007265001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t007265001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t007265001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t007266001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007266001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007266002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007266002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007266003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007266003.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007266004.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007266004.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007266005.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007266005.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007267001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t007267001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t007267001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t007268001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t007268001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t007268002.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t007268002.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t007268003.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t007268003.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t007268004.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t007268004.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t007271001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t007271001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t007271001.1	biological_process	GO:0006497	protein lipidation	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]	OMA
NV2t007271001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t007271001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t007271001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t007271001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t007271001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007271001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t007271001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007271001.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	OMA
NV2t007271001.1	molecular_function	GO:0062078	TSC1-TSC2 complex binding	"Binding to a TSC1-TSC2 complex." [PMID:28561066]	OMA
NV2t007271001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	OMA
NV2t007271001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	PANTHER
NV2t007271002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007271002.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	PANTHER
NV2t007271003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007271003.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	PANTHER
NV2t007272001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t007273001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007273001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007276001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007276001.1	biological_process	GO:0006110	regulation of glycolytic process	"Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators]	OMA
NV2t007276001.1	biological_process	GO:0009895	negative regulation of catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	OMA
NV2t007276001.1	biological_process	GO:0010677	obsolete negative regulation of cellular carbohydrate metabolic process	"OBSOLETE. Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]	OMA
NV2t007276001.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	OMA
NV2t007276001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t007276001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t007276001.1	biological_process	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	OMA
NV2t007276001.1	biological_process	GO:0030308	negative regulation of cell growth	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t007276001.1	biological_process	GO:0042326	negative regulation of phosphorylation	"Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl]	OMA
NV2t007276001.1	biological_process	GO:0043255	regulation of carbohydrate biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]	OMA
NV2t007276001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t007276001.1	biological_process	GO:0046351	disaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units." [GOC:ai]	OMA
NV2t007276001.1	biological_process	GO:0046580	negative regulation of Ras protein signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	OMA
NV2t007276001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t007276001.1	biological_process	GO:0071466	cellular response to xenobiotic stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:krc, GOC:mah]	OMA
NV2t007276001.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t007276001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007276001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007276001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t007276001.1	molecular_function	GO:0019203	carbohydrate phosphatase activity	"Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah]	OMA
NV2t007276001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t007276001.1	molecular_function	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	"Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11]	InterPro
NV2t007276001.1	molecular_function	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	"Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11]	PANTHER
NV2t007276001.1	molecular_function	GO:0042578	phosphoric ester hydrolase activity	"Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]	InterPro
NV2t007276001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t007276001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t007276001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t007276001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t007276001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t007277001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007278001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007279001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t007279001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007279001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t007279001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007279001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t007282001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t007283001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t007283001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t007283001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t007285001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t007285001.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t007285001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	OMA
NV2t007285001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t007285001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	PANTHER
NV2t007286001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007286001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t007286001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007286001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007286002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t007286002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007286002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t007286002.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t007286002.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t007286002.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t007286002.1	biological_process	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t007286002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007286002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007286002.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t007286002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007286002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t007286002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007286003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007286003.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t007286003.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007286003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007289001.1	biological_process	GO:0007606	sensory perception of chemical stimulus	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]	PANTHER
NV2t007289001.1	biological_process	GO:0050909	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai]	InterPro
NV2t007290001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t007290001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007291001.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	OMA
NV2t007291001.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	PANTHER
NV2t007291001.1	biological_process	GO:0046835	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t007291001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007291001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007291001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007291001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t007291001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t007291001.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t007292001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007292001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007293001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007295001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007296001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007296001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t007296001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007296002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007296002.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t007296002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007296003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007296003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t007296003.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t007296003.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t007296003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007296003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007297001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t007297001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t007297001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t007297001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t007297001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007297001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007297001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t007297001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t007297001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t007297001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t007298001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t007298001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t007300001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007300002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007300003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007301001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t007301001.1	biological_process	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t007301001.1	biological_process	GO:0002832	negative regulation of response to biotic stimulus	"Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]	OMA
NV2t007301001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t007301001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t007301001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t007301001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t007301001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t007301001.1	biological_process	GO:0031348	negative regulation of defense response	"Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah]	OMA
NV2t007301001.1	biological_process	GO:0032102	negative regulation of response to external stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t007301001.1	biological_process	GO:0050688	regulation of defense response to virus	"Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]	OMA
NV2t007301001.1	biological_process	GO:0062207	regulation of pattern recognition receptor signaling pathway	"Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]	OMA
NV2t007301001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007301001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t007301001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t007301001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t007301001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t007301001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t007301001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t007301001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t007301002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t007301002.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t007301003.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t007301003.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t007301004.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t007301005.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t007301005.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t007303001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007303001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t007303001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007303002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007303002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007303003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007303003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007304001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007304002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007304003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007304004.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007304005.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007304006.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007304007.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007305001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007305001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t007306001.1	biological_process	GO:0006575	cellular modified amino acid metabolic process	"The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t007306001.1	biological_process	GO:0018958	phenol-containing compound metabolic process	"The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]	OMA
NV2t007306001.1	biological_process	GO:0042445	hormone metabolic process	"The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t007306001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007306001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t007306001.1	molecular_function	GO:0042562	hormone binding	"Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor." [GOC:jl]	OMA
NV2t007306001.1	molecular_function	GO:0042562	hormone binding	"Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor." [GOC:jl]	PANTHER
NV2t007307001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t007307001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	InterPro
NV2t007307001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	OMA
NV2t007307001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007307001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t007307001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t007307001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t007307001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007307001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t007307001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t007309001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	PANTHER
NV2t007309002.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	PANTHER
NV2t007309003.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t007309003.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	PANTHER
NV2t007309004.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	PANTHER
NV2t007310001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007310001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007310001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t007310001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t007310001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t007311001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007311001.1	molecular_function	GO:0120170	intraciliary transport particle B binding	"Binding to an intraciliary transport particle B (IFT B) complex." [PMID:20889716]	PANTHER
NV2t007311002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007311002.1	molecular_function	GO:0120170	intraciliary transport particle B binding	"Binding to an intraciliary transport particle B (IFT B) complex." [PMID:20889716]	PANTHER
NV2t007319001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007319001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t007319001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t007323001.1	biological_process	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	OMA
NV2t007323001.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	PANTHER
NV2t007323001.1	cellular_component	GO:0031931	TORC1 complex	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t007323001.1	cellular_component	GO:0031932	TORC2 complex	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t007323001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007324001.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	PANTHER
NV2t007324001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007330001.1	biological_process	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	OMA
NV2t007330001.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	PANTHER
NV2t007330001.1	cellular_component	GO:0031931	TORC1 complex	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t007330001.1	cellular_component	GO:0031932	TORC2 complex	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t007330001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007335001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	OMA
NV2t007336001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t007337001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	OMA
NV2t007340001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	OMA
NV2t007340001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	PANTHER
NV2t007340001.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t007340001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t007340001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t007343001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t007343001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t007343001.1	molecular_function	GO:0003774	cytoskeletal motor activity	"Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]	OMA
NV2t007343001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007343001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t007345001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t007345001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t007348001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	InterPro
NV2t007348001.1	biological_process	GO:0007007	inner mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t007348001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t007348001.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t007349001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	PANTHER
NV2t007349001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t007350001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t007350001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007350001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t007350001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t007350001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t007350001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007350001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t007350001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007350001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007351001.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	PANTHER
NV2t007351002.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t007351002.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t007351002.1	biological_process	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t007351002.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	OMA
NV2t007351002.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	PANTHER
NV2t007351002.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t007351002.1	molecular_function	GO:0001222	transcription corepressor binding	"Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc]	OMA
NV2t007351002.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t007351002.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	OMA
NV2t007351002.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t007351002.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	OMA
NV2t007351003.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	PANTHER
NV2t007353001.1	molecular_function	GO:0106388	18S rRNA aminocarboxypropyltransferase activity	"Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine." [PMID:27084949]	InterPro
NV2t007357001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t007357001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t007357001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t007357001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t007357001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t007357001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007357001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007359001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t007359001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t007359001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t007359001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	InterPro
NV2t007359002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t007359002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t007359002.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	InterPro
NV2t007359003.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	PANTHER
NV2t007360001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007360001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007360001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007360002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007360002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007360003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007360003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007360004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007360004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007360005.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007360005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007361001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007361001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007361002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007363001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t007363001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007363001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007365001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t007366001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007367001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t007367001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007368001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	PANTHER
NV2t007369001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	PANTHER
NV2t007370001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007370001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007370001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	InterPro
NV2t007370001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t007371001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	PANTHER
NV2t007372001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t007372001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t007372002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t007372002.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t007373001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t007373001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007375001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t007375001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007376001.1	biological_process	GO:0006354	DNA-templated transcription elongation	"The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]	OMA
NV2t007376001.1	biological_process	GO:0006390	mitochondrial transcription	"The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl, PMID:23632312]	OMA
NV2t007376001.1	cellular_component	GO:0042645	mitochondrial nucleoid	"The region of a mitochondrion to which the DNA is confined." [GOC:jl]	OMA
NV2t007376001.1	cellular_component	GO:0042645	mitochondrial nucleoid	"The region of a mitochondrion to which the DNA is confined." [GOC:jl]	PANTHER
NV2t007376001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007376001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007376001.1	molecular_function	GO:0030337	DNA polymerase processivity factor activity	"An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839]	OMA
NV2t007378001.1	biological_process	GO:0030308	negative regulation of cell growth	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t007378001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007378001.1	biological_process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	"Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]	OMA
NV2t007378001.1	biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t007378001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007378001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007378001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007378001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007378001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t007379001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t007381001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007387001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007387001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007387001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007387002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007388001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007388002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007388003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007388004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007391001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t007391001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t007391001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t007391001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t007391001.1	cellular_component	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	"A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838]	PANTHER
NV2t007391001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t007391001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t007391001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007391001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	InterPro
NV2t007391001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t007393001.1	biological_process	GO:0030514	negative regulation of BMP signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]	OMA
NV2t007393001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	InterPro
NV2t007393001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t007394001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	InterPro
NV2t007394002.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	InterPro
NV2t007394003.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	InterPro
NV2t007394004.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	InterPro
NV2t007395001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t007395001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	OMA
NV2t007395001.1	biological_process	GO:0071423	malate transmembrane transport	"A process in which a malate ion is transported across a membrane." [GOC:mah]	PANTHER
NV2t007395001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t007395001.1	molecular_function	GO:0015116	sulfate transmembrane transporter activity	"Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]	OMA
NV2t007395001.1	molecular_function	GO:0015117	thiosulfate transmembrane transporter activity	"Enables the transfer of thiosulfate ions, HS2O3(1-), from one side of a membrane to the other." [GOC:ai]	OMA
NV2t007395001.1	molecular_function	GO:0015131	oxaloacetate transmembrane transporter activity	"Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t007395001.1	molecular_function	GO:0015140	malate transmembrane transporter activity	"Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai]	OMA
NV2t007395001.1	molecular_function	GO:0015141	succinate transmembrane transporter activity	"Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t007395001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t007397001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t007397001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007397001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007398001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t007399001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	PANTHER
NV2t007399001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t007399001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007400001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007400001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007400001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t007400002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007400002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007400002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t007401001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007401001.1	biological_process	GO:1903013	response to differentiation-inducing factor 1	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144]	PANTHER
NV2t007401001.1	molecular_function	GO:0004686	elongation factor-2 kinase activity	"Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN]	InterPro
NV2t007401001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007402001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007402001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007403001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t007404001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007404001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007404001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007404001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t007404001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t007405001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007405001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007405001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007405001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007405001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007405002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007405002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007405002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007405003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007405003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007405003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007405004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007405004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007405004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007405005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007405005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007405005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007405006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007405006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007405006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007407001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007407001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007407001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t007407001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t007407001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t007407002.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007407002.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t007408001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007408001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007408001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007408001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007408001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007408002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007408002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007408002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007408003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007408003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007408003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007408004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007408004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007408004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007408005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007408005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007408005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007408006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007408006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007408006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007410001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t007410001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007410001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t007410002.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t007410002.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t007410002.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t007410002.1	biological_process	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	OMA
NV2t007410002.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t007410002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t007410002.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	OMA
NV2t007410002.1	cellular_component	GO:0032982	myosin filament	"A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah]	OMA
NV2t007410002.1	molecular_function	GO:0000146	microfilament motor activity	"A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]	OMA
NV2t007410002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007410002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007410002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t007410002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t007410002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t007411001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t007411001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007411001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t007412001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007413001.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t007414001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	PANTHER
NV2t007414001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t007414001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t007414001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t007414001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t007414001.1	molecular_function	GO:0019187	beta-1,4-mannosyltransferase activity	"Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage." [GOC:mcc, PMID:8166646]	OMA
NV2t007414002.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	PANTHER
NV2t007414002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t007416001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007416001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t007416001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t007416001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007416001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t007416001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t007416001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t007416001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007419001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007419001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t007419001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t007419001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007419001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t007419001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t007419001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t007419001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007420001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007420001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007423001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007423001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007425001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007425001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t007425001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007425001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007426001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007426001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t007426001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007426001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007427001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007427001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t007434001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t007434001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007434001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007436001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t007439001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t007439001.1	biological_process	GO:0009451	RNA modification	"The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337]	OMA
NV2t007439001.1	biological_process	GO:0035553	obsolete oxidative single-stranded RNA demethylation	"OBSOLETE. Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698]	InterPro
NV2t007439001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t007439001.1	molecular_function	GO:0032451	demethylase activity	"Catalysis of the removal of a methyl group from a substrate." [GOC:mah]	OMA
NV2t007439001.1	molecular_function	GO:0140098	catalytic activity, acting on RNA	"Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t007441001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007441001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007441002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007441002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007441003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007441003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007441003.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t007442001.1	biological_process	GO:0006661	phosphatidylinositol biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]	OMA
NV2t007442001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t007442001.1	biological_process	GO:0008347	glial cell migration	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]	OMA
NV2t007442001.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	OMA
NV2t007442001.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t007442001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t007442001.1	biological_process	GO:0090207	regulation of triglyceride metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]	OMA
NV2t007442001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t007442001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007442001.1	cellular_component	GO:0044233	mitochondria-associated endoplasmic reticulum membrane contact site	"A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109]	OMA
NV2t007442001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t007442001.1	molecular_function	GO:0071617	lysophospholipid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]	OMA
NV2t007442001.1	molecular_function	GO:0071617	lysophospholipid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]	PANTHER
NV2t007442002.1	molecular_function	GO:0071617	lysophospholipid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]	PANTHER
NV2t007444001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007444001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t007446001.1	biological_process	GO:0009913	epidermal cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]	OMA
NV2t007446001.1	biological_process	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	OMA
NV2t007446001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t007446001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t007446001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t007446001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t007446001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007446001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007446001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007446001.1	molecular_function	GO:0050291	sphingosine N-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]	InterPro
NV2t007446001.1	molecular_function	GO:0050291	sphingosine N-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]	OMA
NV2t007446001.1	molecular_function	GO:0050291	sphingosine N-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]	PANTHER
NV2t007447001.1	molecular_function	GO:0043495	protein-membrane adaptor activity	"The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle." [GOC:go_curators]	PANTHER
NV2t007449001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t007449001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	PANTHER
NV2t007449001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t007451001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t007451001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007451001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t007452001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t007452001.1	biological_process	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	OMA
NV2t007452001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007452001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t007452001.1	molecular_function	GO:0016972	thiol oxidase activity	"Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357]	InterPro
NV2t007452001.1	molecular_function	GO:0016972	thiol oxidase activity	"Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357]	OMA
NV2t007452001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t007452001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t007452002.1	molecular_function	GO:0016972	thiol oxidase activity	"Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357]	InterPro
NV2t007452002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t007454001.1	biological_process	GO:0072344	rescue of stalled ribosome	"A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543]	PANTHER
NV2t007456001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007456001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t007456002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t007456002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007456002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t007456002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007456002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007456002.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t007458001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t007458001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007458001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007460001.1	biological_process	GO:0032049	cardiolipin biosynthetic process	"The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah]	PANTHER
NV2t007461001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t007461001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t007461001.1	biological_process	GO:0036158	outer dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t007461001.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t007461001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t007461001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t007461001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007461001.1	molecular_function	GO:0045503	dynein light chain binding	"Binding to a light chain of the dynein complex." [GOC:bf]	OMA
NV2t007461001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	OMA
NV2t007461001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t007462001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007463001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007463001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007464001.1	cellular_component	GO:0031519	PcG protein complex	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]	PANTHER
NV2t007465001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007465001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t007465001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t007466001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	OMA
NV2t007466001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t007466001.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t007466001.1	cellular_component	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	"A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]	OMA
NV2t007466001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007466001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007466001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007466001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007471001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t007472001.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	OMA
NV2t007472001.1	biological_process	GO:0046104	thymidine metabolic process	"The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]	PANTHER
NV2t007472001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t007472001.1	biological_process	GO:0072527	pyrimidine-containing compound metabolic process	"The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t007472001.1	molecular_function	GO:0004797	thymidine kinase activity	"Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21]	OMA
NV2t007472001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007472001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007472001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007472001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t007472002.1	biological_process	GO:0046104	thymidine metabolic process	"The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]	PANTHER
NV2t007472002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007472003.1	biological_process	GO:0046104	thymidine metabolic process	"The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]	PANTHER
NV2t007472003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007473001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t007473002.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t007474001.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	PANTHER
NV2t007474002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007474002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007474002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007474002.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	PANTHER
NV2t007475001.1	biological_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	"The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]	InterPro
NV2t007475001.1	biological_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	"The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]	OMA
NV2t007476002.1	biological_process	GO:0030322	stabilization of membrane potential	"The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t007476002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007476002.1	molecular_function	GO:0015271	outward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]	OMA
NV2t007476002.1	molecular_function	GO:0022841	potassium ion leak channel activity	"Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007482001.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	PANTHER
NV2t007484001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007484001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007484001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007484001.1	molecular_function	GO:0015276	ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007485001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007487001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	InterPro
NV2t007487001.1	biological_process	GO:0022604	regulation of cell morphogenesis	"Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete]	OMA
NV2t007487001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t007487001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t007487001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t007487001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t007487001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t007488001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007488001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007488001.1	cellular_component	GO:0031594	neuromuscular junction	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]	PANTHER
NV2t007489001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007489001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	PANTHER
NV2t007490001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007493001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t007493001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007494001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	InterPro
NV2t007494001.1	biological_process	GO:0072684	obsolete mitochondrial tRNA 3'-trailer cleavage, endonucleolytic	"OBSOLETE. Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah]	OMA
NV2t007494001.1	biological_process	GO:0072684	obsolete mitochondrial tRNA 3'-trailer cleavage, endonucleolytic	"OBSOLETE. Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah]	PANTHER
NV2t007494001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007494001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007494001.1	molecular_function	GO:0042781	3'-tRNA processing endoribonuclease activity	"Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [PMID:12032089, PMID:21208191]	OMA
NV2t007494002.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	InterPro
NV2t007494002.1	biological_process	GO:0072684	obsolete mitochondrial tRNA 3'-trailer cleavage, endonucleolytic	"OBSOLETE. Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah]	PANTHER
NV2t007495001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	InterPro
NV2t007495001.1	biological_process	GO:0072684	obsolete mitochondrial tRNA 3'-trailer cleavage, endonucleolytic	"OBSOLETE. Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah]	PANTHER
NV2t007496001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t007496001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	PANTHER
NV2t007496002.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	PANTHER
NV2t007497001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007499001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007499001.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t007499001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007499001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t007499001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007499001.1	molecular_function	GO:0005385	zinc ion transmembrane transporter activity	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t007502001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007503001.1	biological_process	GO:0007606	sensory perception of chemical stimulus	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]	PANTHER
NV2t007503001.1	biological_process	GO:0050912	detection of chemical stimulus involved in sensory perception of taste	"The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]	InterPro
NV2t007503001.1	molecular_function	GO:0008527	taste receptor activity	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]	OMA
NV2t007504001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	InterPro
NV2t007504001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t007504001.1	molecular_function	GO:0008527	taste receptor activity	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]	OMA
NV2t007509001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t007509001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007510001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t007510001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t007510001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007510001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t007510001.1	molecular_function	GO:0004300	enoyl-CoA hydratase activity	"Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17]	OMA
NV2t007512001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t007512001.1	biological_process	GO:0043086	negative regulation of catalytic activity	"Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007512001.1	biological_process	GO:0051341	regulation of oxidoreductase activity	"Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:ai]	OMA
NV2t007512001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007512001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007512001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t007512001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t007513001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007513001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007513001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t007513001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007514001.1	biological_process	GO:0006265	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	InterPro
NV2t007514001.1	molecular_function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	InterPro
NV2t007514001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007514002.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t007514002.1	biological_process	GO:0006265	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	InterPro
NV2t007514002.1	biological_process	GO:0006265	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	OMA
NV2t007514002.1	biological_process	GO:0032042	mitochondrial DNA metabolic process	"The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah]	OMA
NV2t007514002.1	biological_process	GO:0051304	chromosome separation	"The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243]	OMA
NV2t007514002.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t007514002.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t007514002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t007514002.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t007514002.1	molecular_function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	InterPro
NV2t007514002.1	molecular_function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	OMA
NV2t007514002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007514002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007515002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007515003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007516001.1	biological_process	GO:0046512	sphingosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732]	PANTHER
NV2t007516001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t007516001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t007517001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t007517001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t007517001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t007517001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007517001.1	cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]	OMA
NV2t007517001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007517001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	OMA
NV2t007517001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t007521001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t007521001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t007521001.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t007521001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007521001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t007521001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007521001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007521001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007521001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007521002.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t007521002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007521002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007521003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007521003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007521004.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t007521004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007521004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007521005.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t007521005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007521005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007522001.1	biological_process	GO:0007094	mitotic spindle assembly checkpoint signaling	"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]	InterPro
NV2t007522001.1	biological_process	GO:0007094	mitotic spindle assembly checkpoint signaling	"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]	OMA
NV2t007522001.1	biological_process	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	"The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in mitosis." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]	OMA
NV2t007522001.1	biological_process	GO:0090235	regulation of metaphase plate congression	"Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t007522001.1	biological_process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	"Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw]	OMA
NV2t007522001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t007522001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007522001.1	cellular_component	GO:0044615	nuclear pore nuclear basket	"A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t007522001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t007522001.1	cellular_component	GO:0097431	mitotic spindle pole	"Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]	OMA
NV2t007522001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t007522001.1	molecular_function	GO:0043515	kinetochore binding	"Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl]	OMA
NV2t007524001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t007524001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007524002.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t007524002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007525001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t007525001.1	biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	"The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t007525001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t007525001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t007525001.1	biological_process	GO:0008286	insulin receptor signaling pathway	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]	OMA
NV2t007525001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t007525001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t007525001.1	biological_process	GO:0022414	reproductive process	"A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]	OMA
NV2t007525001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t007525001.1	biological_process	GO:0032535	regulation of cellular component size	"A process that modulates the size of a cellular component." [GOC:mah]	OMA
NV2t007525001.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	OMA
NV2t007525001.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t007525001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t007525001.1	biological_process	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t007525001.1	biological_process	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	OMA
NV2t007525001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t007525001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t007525001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007525001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	OMA
NV2t007525001.1	cellular_component	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]	OMA
NV2t007525001.1	molecular_function	GO:0001784	phosphotyrosine residue binding	"Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584]	OMA
NV2t007525001.1	molecular_function	GO:0005154	epidermal growth factor receptor binding	"Binding to an epidermal growth factor receptor." [GOC:ai]	OMA
NV2t007525001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007525001.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	OMA
NV2t007530001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t007530001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t007531001.1	biological_process	GO:0003143	embryonic heart tube morphogenesis	"The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]	OMA
NV2t007531001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t007531001.1	biological_process	GO:0006858	extracellular transport	"The transport of substances that occurs outside cells." [GOC:go_curators]	OMA
NV2t007531001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t007531001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	InterPro
NV2t007531001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t007531001.1	biological_process	GO:0099111	microtubule-based transport	"A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t007531001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007531001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t007533001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t007533001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t007533001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007533001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t007533001.1	molecular_function	GO:0004300	enoyl-CoA hydratase activity	"Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17]	OMA
NV2t007533001.1	molecular_function	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3.-, GOC:mah]	OMA
NV2t007535001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t007535001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t007535001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t007536001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t007536001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007538001.1	biological_process	GO:0070914	UV-damage excision repair	"A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]	PANTHER
NV2t007539001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t007539001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t007543001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t007543002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t007544001.1	biological_process	GO:0070914	UV-damage excision repair	"A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]	PANTHER
NV2t007546001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t007546001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t007546001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007547001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007547001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t007547002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007547002.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t007548001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007548002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007548003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007548004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007548005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007548006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007548007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007548007.1	molecular_function	GO:0140911	pore-forming activity	"An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death." [PMID:1406491, PMID:25157079, PMID:34387717]	InterPro
NV2t007550001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	OMA
NV2t007550001.1	biological_process	GO:0007178	cell surface receptor protein serine/threonine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t007550001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t007550001.1	biological_process	GO:0019218	regulation of steroid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]	OMA
NV2t007550001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t007550001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t007550001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t007550001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t007550001.1	biological_process	GO:0032350	regulation of hormone metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]	OMA
NV2t007550001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t007550001.1	biological_process	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	OMA
NV2t007550001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	OMA
NV2t007550001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t007550001.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	OMA
NV2t007550001.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	PANTHER
NV2t007550001.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	OMA
NV2t007550001.1	biological_process	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	OMA
NV2t007550001.1	biological_process	GO:0090287	regulation of cellular response to growth factor stimulus	"Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]	OMA
NV2t007550001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t007550001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t007550001.1	cellular_component	GO:0030018	Z disc	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]	OMA
NV2t007550001.1	cellular_component	GO:0042405	nuclear inclusion body	"An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl]	OMA
NV2t007550001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t007550001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t007550001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007550001.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	OMA
NV2t007550001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t007550001.1	molecular_function	GO:0030911	TPR domain binding	"Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah]	OMA
NV2t007550001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t007550001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t007550001.1	molecular_function	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	OMA
NV2t007550001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t007550001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t007550001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t007550002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t007550002.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	PANTHER
NV2t007550002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007550003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t007550003.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	PANTHER
NV2t007550003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007550004.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t007550004.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	PANTHER
NV2t007550004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007551001.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t007551002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007551002.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t007551002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t007551003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007551003.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t007551003.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t007551004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007551004.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t007551004.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t007551005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007551005.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t007551005.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t007551006.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t007553001.1	biological_process	GO:0000712	resolution of meiotic recombination intermediates	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]	OMA
NV2t007553001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t007553001.1	biological_process	GO:0007129	homologous chromosome pairing at meiosis	"The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]	OMA
NV2t007553001.1	biological_process	GO:0007140	male meiotic nuclear division	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw]	OMA
NV2t007553001.1	biological_process	GO:0007144	female meiosis I	"The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah]	OMA
NV2t007553001.1	biological_process	GO:0009566	fertilization	"The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732]	OMA
NV2t007553001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007553001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t007553001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t007553001.1	molecular_function	GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]	OMA
NV2t007553001.1	molecular_function	GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]	PANTHER
NV2t007554001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t007554001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t007554001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t007554001.1	biological_process	GO:0007096	regulation of exit from mitosis	"Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]	OMA
NV2t007554001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t007554001.1	biological_process	GO:0032467	positive regulation of cytokinesis	"Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]	OMA
NV2t007554001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t007554001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t007554001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007554001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t007554001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t007554001.1	cellular_component	GO:1902636	kinociliary basal body	"A ciliary basal body that is part of a kinocilium." [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574]	PANTHER
NV2t007554001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t007554001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t007554001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t007555001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t007555001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007555001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007555001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t007556001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t007557001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007557001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007557001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007557002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007558001.1	biological_process	GO:0006835	dicarboxylic acid transport	"The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t007558001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t007558001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007558001.1	biological_process	GO:0097254	renal tubular secretion	"The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion]	OMA
NV2t007558001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t007558001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t007558001.1	molecular_function	GO:0005452	solute:inorganic anion antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)." [GOC:mah]	OMA
NV2t007558001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007558001.1	molecular_function	GO:0008514	organic anion transmembrane transporter activity	"Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t007558001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t007558002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007558002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t007560001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007564001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007564001.1	molecular_function	GO:0072320	volume-sensitive chloride channel activity	"Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah]	PANTHER
NV2t007565001.1	cellular_component	GO:0055038	recycling endosome membrane	"The lipid bilayer surrounding a recycling endosome." [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]	PANTHER
NV2t007570001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t007570001.1	biological_process	GO:0042246	tissue regeneration	"The regrowth of lost or destroyed tissues." [GOC:curators]	InterPro
NV2t007570001.1	biological_process	GO:0042246	tissue regeneration	"The regrowth of lost or destroyed tissues." [GOC:curators]	OMA
NV2t007572001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t007601001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t007601001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	OMA
NV2t007601001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t007601001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t007601001.1	molecular_function	GO:0018423	protein C-terminal leucine carboxyl O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + [protein]-L-leucine = S-adenosyl-L-homocysteine + [protein]-L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774]	PANTHER
NV2t007601002.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t007601002.1	molecular_function	GO:0018423	protein C-terminal leucine carboxyl O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + [protein]-L-leucine = S-adenosyl-L-homocysteine + [protein]-L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774]	PANTHER
NV2t007605001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t007605001.1	biological_process	GO:0009410	response to xenobiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:jl, GOC:krc]	OMA
NV2t007605001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t007605001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t007605001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007605001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t007605001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007605001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007605001.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t007605001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t007605001.1	molecular_function	GO:0030942	endoplasmic reticulum signal peptide binding	"Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah]	InterPro
NV2t007605001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t007608001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t007608001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007608001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007608001.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	InterPro
NV2t007609001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t007609001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t007609001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007609001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007611001.1	biological_process	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	PANTHER
NV2t007611001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007611001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007612001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t007612001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t007614001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t007614001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007614001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007614001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t007615001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007615001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t007615001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t007624001.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	OMA
NV2t007624001.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	PANTHER
NV2t007624001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007624001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t007624001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t007624001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007629001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007629001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	InterPro
NV2t007629001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t007630001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007631001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007631001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007631001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t007633001.1	cellular_component	GO:0071007	U2-type catalytic step 2 spliceosome	"A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t007633001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007633001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007633001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007635001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t007636001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007636001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t007636001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t007636001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007636001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t007636002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007636002.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007636003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007636003.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007636004.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007636004.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007636005.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007636005.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007636006.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007636006.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t007637001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t007637001.1	biological_process	GO:0030490	maturation of SSU-rRNA	"Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators]	PANTHER
NV2t007637001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t007637001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t007637001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007637002.1	biological_process	GO:0030490	maturation of SSU-rRNA	"Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators]	PANTHER
NV2t007637002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t007637002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007637003.1	biological_process	GO:0030490	maturation of SSU-rRNA	"Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators]	PANTHER
NV2t007637003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t007637003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007638001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t007638001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t007638001.1	biological_process	GO:0006497	protein lipidation	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]	OMA
NV2t007638001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t007638001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t007638001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t007638001.1	biological_process	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	OMA
NV2t007638001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t007638001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t007638001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007638001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t007638001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007638001.1	molecular_function	GO:0010314	phosphatidylinositol-5-phosphate binding	"Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators]	OMA
NV2t007638001.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	OMA
NV2t007638001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	OMA
NV2t007638001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	PANTHER
NV2t007640001.1	biological_process	GO:0072530	purine-containing compound transmembrane transport	"The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t007640001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t007640001.1	molecular_function	GO:0005347	ATP transmembrane transporter activity	"Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t007640001.1	molecular_function	GO:0015101	organic cation transmembrane transporter activity	"Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007640001.1	molecular_function	GO:0015217	ADP transmembrane transporter activity	"Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t007640001.1	molecular_function	GO:0080122	AMP transmembrane transporter activity	"Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other." [PMID:18923018]	PANTHER
NV2t007642001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007642002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007643001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t007643001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t007643001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t007643001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t007643001.1	biological_process	GO:0030865	cortical cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t007643001.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	OMA
NV2t007643001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t007643001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007643001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t007643001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t007643001.1	cellular_component	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t007643001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t007643001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t007643001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007643001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007643001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t007645001.1	biological_process	GO:1903723	negative regulation of centriole elongation	"Any process that stops, prevents or reduces the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]	PANTHER
NV2t007646001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t007646001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007646001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007648001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t007648001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t007648001.1	biological_process	GO:0035522	obsolete monoubiquitinated histone H2A deubiquitination	"OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]	OMA
NV2t007648001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t007648001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t007648001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007648001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007649001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	InterPro
NV2t007649001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	OMA
NV2t007649001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t007649001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t007650001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t007650001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	PANTHER
NV2t007650002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t007650002.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	PANTHER
NV2t007651001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t007651001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t007651001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t007653001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t007653001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t007653001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t007654001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	InterPro
NV2t007654001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t007655001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t007655001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t007655001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t007655001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007655001.1	molecular_function	GO:0003727	single-stranded RNA binding	"Binding to single-stranded RNA." [GOC:jl]	OMA
NV2t007655001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t007655001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	PANTHER
NV2t007655002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t007655002.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	PANTHER
NV2t007655003.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t007655003.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	PANTHER
NV2t007656001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t007656001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t007656001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t007656001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t007657001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t007658001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t007658001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t007658001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t007658001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007658001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007658001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007658001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007660001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007660001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t007660001.1	cellular_component	GO:0008541	proteasome regulatory particle, lid subcomplex	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]	PANTHER
NV2t007660001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t007660001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t007660001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007661001.1	biological_process	GO:0001738	morphogenesis of a polarized epithelium	"The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]	OMA
NV2t007661001.1	biological_process	GO:0001952	regulation of cell-matrix adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]	OMA
NV2t007661001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t007661001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t007661001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t007661001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t007661001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t007661001.1	biological_process	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t007661001.1	biological_process	GO:0051492	regulation of stress fiber assembly	"Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	OMA
NV2t007661001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t007661001.1	biological_process	GO:0090303	positive regulation of wound healing	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]	OMA
NV2t007661001.1	biological_process	GO:0099188	postsynaptic cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]	OMA
NV2t007661001.1	biological_process	GO:0120192	tight junction assembly	"A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:rl]	OMA
NV2t007661001.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	OMA
NV2t007661001.1	biological_process	GO:1901888	regulation of cell junction assembly	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t007661001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007661001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t007661001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007661001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t007661001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t007661001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t007661001.1	cellular_component	GO:0043296	apical junction complex	"A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]	OMA
NV2t007661001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t007661001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t007661001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t007661001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t007667001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t007667001.1	biological_process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]	OMA
NV2t007667001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t007667001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t007667001.1	molecular_function	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	"Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23]	OMA
NV2t007667001.1	molecular_function	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	"Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23]	PANTHER
NV2t007668001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007668001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007668001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007668001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t007670001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t007672001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t007672001.1	biological_process	GO:2000251	obsolete positive regulation of actin cytoskeleton reorganization	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]	PANTHER
NV2t007672001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007674001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t007674001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007677001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007678001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007678001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007678001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t007678001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t007678002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007679001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t007679001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007680001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t007680001.1	biological_process	GO:0034474	U2 snRNA 3'-end processing	"Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah]	InterPro
NV2t007680001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	OMA
NV2t007680002.1	biological_process	GO:0034474	U2 snRNA 3'-end processing	"Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah]	InterPro
NV2t007681001.1	biological_process	GO:0000002	mitochondrial genome maintenance	"The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]	OMA
NV2t007681001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007681001.1	biological_process	GO:0072531	pyrimidine-containing compound transmembrane transport	"The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t007681001.1	biological_process	GO:1990519	pyrimidine nucleotide import into mitochondrion	"The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix." [PMID:16194150]	PANTHER
NV2t007681001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t007681001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007681001.1	molecular_function	GO:0015215	nucleotide transmembrane transporter activity	"Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t007683001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007683001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t007684001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007684001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t007684001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007685001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t007685002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t007685003.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t007686001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007686001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007686001.1	molecular_function	GO:0015276	ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007686002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007686003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007686004.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007686005.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007686006.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007686007.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007686008.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686008.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007686009.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007686009.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007687001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007687002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t007690001.1	molecular_function	GO:0008418	protein-N-terminal asparagine amidohydrolase activity	"Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481, RHEA:50676]	InterPro
NV2t007690001.1	molecular_function	GO:0008418	protein-N-terminal asparagine amidohydrolase activity	"Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481, RHEA:50676]	PANTHER
NV2t007690002.1	molecular_function	GO:0008418	protein-N-terminal asparagine amidohydrolase activity	"Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481, RHEA:50676]	InterPro
NV2t007690002.1	molecular_function	GO:0008418	protein-N-terminal asparagine amidohydrolase activity	"Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481, RHEA:50676]	PANTHER
NV2t007690003.1	molecular_function	GO:0008418	protein-N-terminal asparagine amidohydrolase activity	"Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481, RHEA:50676]	InterPro
NV2t007690003.1	molecular_function	GO:0008418	protein-N-terminal asparagine amidohydrolase activity	"Catalysis of the reaction: N-terminal L-asparaginyl-[protein] + H+ + H2O = N-terminal L-aspartyl-[protein] + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481, RHEA:50676]	PANTHER
NV2t007690004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t007690004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007690004.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007693001.1	biological_process	GO:0006384	transcription initiation at RNA polymerase III promoter	"A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]	InterPro
NV2t007693001.1	biological_process	GO:0006384	transcription initiation at RNA polymerase III promoter	"A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]	OMA
NV2t007693001.1	cellular_component	GO:0090576	RNA polymerase III transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III." [GOC:tb]	OMA
NV2t007693001.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	OMA
NV2t007693001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007695001.1	cellular_component	GO:0070939	Dsl1/NZR complex	"A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722, PMID:21550981]	InterPro
NV2t007695001.1	cellular_component	GO:0070939	Dsl1/NZR complex	"A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722, PMID:21550981]	PANTHER
NV2t007697001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t007697001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t007697001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t007697001.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	InterPro
NV2t007697001.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	OMA
NV2t007697001.1	biological_process	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	OMA
NV2t007697001.1	biological_process	GO:1903461	Okazaki fragment processing involved in mitotic DNA replication	"Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234]	PANTHER
NV2t007697001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007697001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007697001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007697001.1	molecular_function	GO:0003909	DNA ligase activity	"Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094]	InterPro
NV2t007697001.1	molecular_function	GO:0003910	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	OMA
NV2t007697001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007698001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	PANTHER
NV2t007698001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007700001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t007702001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007702002.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	InterPro
NV2t007702002.1	biological_process	GO:0032488	Cdc42 protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478]	PANTHER
NV2t007702002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007702002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007702003.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	InterPro
NV2t007702003.1	biological_process	GO:0032488	Cdc42 protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478]	PANTHER
NV2t007702003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007702003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007702004.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	InterPro
NV2t007702004.1	biological_process	GO:0032488	Cdc42 protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478]	PANTHER
NV2t007702004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007702004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007705001.1	biological_process	GO:0010824	regulation of centrosome duplication	"Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]	OMA
NV2t007705001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t007705001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t007705001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t007705001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t007705001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007706001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t007706001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t007706001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t007706001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t007706001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	InterPro
NV2t007706001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t007706001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t007706001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t007706001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t007706001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007706001.1	molecular_function	GO:0030621	U4 snRNA binding	"Binding to a U4 small nuclear RNA (U4 snRNA)." [GOC:jl]	OMA
NV2t007706001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	OMA
NV2t007712001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t007712001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t007712001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	PANTHER
NV2t007712001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007713001.1	cellular_component	GO:0031304	obsolete intrinsic component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t007713001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t007714001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t007714001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007714001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007715001.1	molecular_function	GO:0033925	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	"Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96]	InterPro
NV2t007715002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007715002.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t007715002.1	molecular_function	GO:0033925	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	"Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96]	InterPro
NV2t007716001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t007716001.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t007716002.1	biological_process	GO:0034975	protein folding in endoplasmic reticulum	"A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw]	OMA
NV2t007716002.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t007716002.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t007716002.1	biological_process	GO:0046598	positive regulation of viral entry into host cell	"Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell." [GOC:jl]	OMA
NV2t007716002.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	OMA
NV2t007716002.1	biological_process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	"Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]	OMA
NV2t007716002.1	biological_process	GO:1903201	obsolete regulation of oxidative stress-induced cell death	"OBSOLETE. Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]	OMA
NV2t007716002.1	biological_process	GO:2001242	regulation of intrinsic apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t007716002.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t007716002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007716002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t007716002.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t007716002.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t007716002.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t007716002.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t007716002.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t007716002.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t007716002.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t007716002.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t007716002.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t007716002.1	molecular_function	GO:0016972	thiol oxidase activity	"Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357]	OMA
NV2t007716002.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t007716002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t007716003.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t007716003.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t007717001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	InterPro
NV2t007717001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t007717001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	OMA
NV2t007717001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t007717001.1	biological_process	GO:0071526	semaphorin-plexin signaling pathway	"The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]	OMA
NV2t007717001.1	biological_process	GO:2000249	obsolete regulation of actin cytoskeleton reorganization	"OBSOLETE. Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]	OMA
NV2t007717001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007717001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007717001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t007717001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t007717001.1	molecular_function	GO:0005092	GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]	OMA
NV2t007717001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007723001.1	biological_process	GO:0000272	polysaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]	InterPro
NV2t007723002.1	biological_process	GO:0000272	polysaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]	InterPro
NV2t007723003.1	biological_process	GO:0000272	polysaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]	InterPro
NV2t007723004.1	biological_process	GO:0000272	polysaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]	InterPro
NV2t007725001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t007725001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t007727001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007727002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007727003.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007728001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007728002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728002.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007728003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728003.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007728004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728004.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007728004.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007728005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728005.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007728005.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007728006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728006.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007728007.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728007.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007728007.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007728008.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728008.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t007728008.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007728009.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007728009.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t007729001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t007729002.1	biological_process	GO:0000338	protein deneddylation	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]	OMA
NV2t007729002.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	OMA
NV2t007729002.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t007729002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007729003.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t007729003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007729004.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t007729004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007730001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t007730001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007733001.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t007733001.1	biological_process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]	OMA
NV2t007733001.1	biological_process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]	OMA
NV2t007733001.1	biological_process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]	PANTHER
NV2t007733001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007733001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t007733001.1	molecular_function	GO:0030158	protein xylosyltransferase activity	"Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26]	OMA
NV2t007734001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t007734001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007734002.1	biological_process	GO:0016358	dendrite development	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]	PANTHER
NV2t007734003.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t007734003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007734004.1	biological_process	GO:0016358	dendrite development	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]	PANTHER
NV2t007734005.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t007734005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007735001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t007735001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007735001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007735001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007735001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t007737001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t007737001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t007737001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	OMA
NV2t007737001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	OMA
NV2t007737001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t007737001.1	biological_process	GO:1903076	regulation of protein localization to plasma membrane	"Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]	OMA
NV2t007737001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t007737001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t007737001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t007737001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t007737001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t007737001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t007737001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t007737001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t007737001.1	molecular_function	GO:0099106	ion channel regulator activity	"Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:dos]	OMA
NV2t007737001.1	molecular_function	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t007738001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t007748001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007749001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t007749001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t007750001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t007750001.1	molecular_function	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]	InterPro
NV2t007750001.1	molecular_function	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]	OMA
NV2t007751001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t007751001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t007752001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t007752001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007752001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007753001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007753001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007753001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007753002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t007754001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007754001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007754001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007754001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t007755001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007755001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007755001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t007755001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t007755001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t007759001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t007759001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t007760001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t007760001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t007760001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t007760001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t007761001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t007761001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007761001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t007763001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007763001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t007763001.1	molecular_function	GO:0070513	death domain binding	"Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]	InterPro
NV2t007764001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t007764001.1	biological_process	GO:0035076	ecdysone receptor-mediated signaling pathway	"The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf]	OMA
NV2t007764001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007764001.1	biological_process	GO:0045931	positive regulation of mitotic cell cycle	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t007764001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007764001.1	biological_process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	"Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT." [GOC:bf]	OMA
NV2t007764001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t007764001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007764001.1	cellular_component	GO:0005705	polytene chromosome interband	"A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]	OMA
NV2t007764001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t007764001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t007764001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t007764001.1	molecular_function	GO:0043035	chromatin insulator sequence binding	"Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]	PANTHER
NV2t007765001.1	biological_process	GO:0070830	bicellular tight junction assembly	"The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah]	PANTHER
NV2t007765002.1	biological_process	GO:0070830	bicellular tight junction assembly	"The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah]	PANTHER
NV2t007769001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007769012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007770001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007770001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t007770001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t007770001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t007770001.1	biological_process	GO:0007129	homologous chromosome pairing at meiosis	"The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]	OMA
NV2t007770001.1	biological_process	GO:0009303	rRNA transcription	"The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732]	OMA
NV2t007770001.1	biological_process	GO:0010458	exit from mitosis	"The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]	OMA
NV2t007770001.1	biological_process	GO:0010529	obsolete negative regulation of transposition	"OBSOLETE. Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]	OMA
NV2t007770001.1	biological_process	GO:0010821	regulation of mitochondrion organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	OMA
NV2t007770001.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	OMA
NV2t007770001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t007770001.1	biological_process	GO:0018205	peptidyl-lysine modification	"The modification of peptidyl-lysine." [GOC:go_curators]	OMA
NV2t007770001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t007770001.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t007770001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t007770001.1	biological_process	GO:0043255	regulation of carbohydrate biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]	OMA
NV2t007770001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007770001.1	biological_process	GO:0046825	regulation of protein export from nucleus	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf]	OMA
NV2t007770001.1	biological_process	GO:1901836	regulation of transcription of nucleolar large rRNA by RNA polymerase I	"Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie]	OMA
NV2t007770001.1	biological_process	GO:2000779	regulation of double-strand break repair	"Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t007770001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t007770001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t007770001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t007770001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t007770001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t007770001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t007770001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t007770001.1	molecular_function	GO:0016410	N-acyltransferase activity	"Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t007770001.1	molecular_function	GO:0017136	NAD-dependent histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [PMID:28450737]	OMA
NV2t007770001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t007770001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t007770001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t007770001.1	molecular_function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein." [GOC:sp, PMID:22722849, PMID:28450737]	PANTHER
NV2t007771001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t007773001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t007773001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t007773001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t007773001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t007773001.1	biological_process	GO:0030865	cortical cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t007773001.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	OMA
NV2t007773001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	OMA
NV2t007773001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	PANTHER
NV2t007773001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t007773001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007773001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t007773001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t007773001.1	cellular_component	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t007773001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t007773001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007773001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007773001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t007773003.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	PANTHER
NV2t007773003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007774001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t007775001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007776001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t007777001.1	molecular_function	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	"Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25033]	OMA
NV2t007778001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t007778002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t007779001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t007779002.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t007779003.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t007780001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t007780001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007781001.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007781001.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	OMA
NV2t007781001.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007781001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t007781001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t007781002.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007781002.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007781003.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	InterPro
NV2t007781003.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t007782001.1	biological_process	GO:0030166	proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]	OMA
NV2t007782001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007782001.1	molecular_function	GO:0004382	GDP phosphatase activity	"Catalysis of the reaction: GDP + H2O = GMP + phosphate." [PMID:2989286, RHEA:22156]	OMA
NV2t007782001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t007782001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007782001.1	molecular_function	GO:0017110	nucleoside diphosphate phosphatase activity	"Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate." [EC:3.6.1.6]	InterPro
NV2t007782001.1	molecular_function	GO:0043262	ADP phosphatase activity	"Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+." [PMID:1470606, RHEA:61436]	OMA
NV2t007782001.1	molecular_function	GO:0045134	UDP phosphatase activity	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]	OMA
NV2t007782001.1	molecular_function	GO:0045134	UDP phosphatase activity	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]	PANTHER
NV2t007785001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t007785001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t007785001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t007785001.1	biological_process	GO:0006296	obsolete nucleotide-excision repair, DNA incision, 5'-to lesion	"OBSOLETE. The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977]	PANTHER
NV2t007785001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007785001.1	molecular_function	GO:0000702	oxidized base lesion DNA N-glycosylase activity	"Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]	OMA
NV2t007785001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007785001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007785001.1	molecular_function	GO:0019104	DNA N-glycosylase activity	"Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]	InterPro
NV2t007785001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t007785001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t007785001.1	molecular_function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate." [PMID:1698278, RHEA:66592]	OMA
NV2t007787001.1	cellular_component	GO:0032588	trans-Golgi network membrane	"The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]	PANTHER
NV2t007787003.1	cellular_component	GO:0032588	trans-Golgi network membrane	"The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]	PANTHER
NV2t007788001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007789001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t007789001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007789001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007789001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007789002.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t007789002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007789002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007790001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t007790001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t007790001.1	molecular_function	GO:0017150	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H." [PMID:11983710, PMID:22123979]	PANTHER
NV2t007790001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t007790001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t007790001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t007791001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t007791002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t007792001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t007792001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t007794002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007794002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t007794002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007794003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007794003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t007794003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007794006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007794006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t007794006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007795001.1	biological_process	GO:0042038	peptidyl-histidine methylation, to form tele-methylhistidine	"The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317]	PANTHER
NV2t007796001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t007796001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t007796001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	OMA
NV2t007796001.1	biological_process	GO:0071806	protein transmembrane transport	"The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw]	OMA
NV2t007796001.1	biological_process	GO:0090151	establishment of protein localization to mitochondrial membrane	"The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t007796001.1	cellular_component	GO:0098799	outer mitochondrial membrane protein complex	"Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos]	OMA
NV2t007797001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t007798001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	InterPro
NV2t007798002.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	InterPro
NV2t007798003.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	InterPro
NV2t007799001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t007799001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	InterPro
NV2t007799001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t007799001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t007799001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007799001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t007799001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007799001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t007800001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t007800001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007801001.1	biological_process	GO:0046900	tetrahydrofolylpolyglutamate metabolic process	"The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t007801001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	InterPro
NV2t007801001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007802001.1	biological_process	GO:0009448	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	InterPro
NV2t007802001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t007802001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t007802001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007802002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007802003.1	biological_process	GO:0009448	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	InterPro
NV2t007802003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007802004.1	biological_process	GO:0009448	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	InterPro
NV2t007802004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007802005.1	biological_process	GO:0009448	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	InterPro
NV2t007802005.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802005.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007802006.1	biological_process	GO:0009448	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	InterPro
NV2t007802006.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802006.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007802007.1	biological_process	GO:0009448	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	InterPro
NV2t007802007.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802007.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007802008.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802008.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007802009.1	biological_process	GO:0009448	gamma-aminobutyric acid metabolic process	"The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732]	InterPro
NV2t007802009.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007802009.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t007804001.1	biological_process	GO:0007100	mitotic centrosome separation	"Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]	OMA
NV2t007804001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t007804001.1	biological_process	GO:0051642	centrosome localization	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t007804001.1	biological_process	GO:0060052	neurofilament cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph]	OMA
NV2t007804001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t007809001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007809001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t007809001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t007809001.1	biological_process	GO:0009190	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t007809001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007809001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t007809001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t007809001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007809001.1	molecular_function	GO:0016849	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t007809002.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t007809002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007812001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007812001.1	biological_process	GO:0061172	regulation of establishment of bipolar cell polarity	"Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]	PANTHER
NV2t007812001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007812002.1	biological_process	GO:0061172	regulation of establishment of bipolar cell polarity	"Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]	PANTHER
NV2t007812002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007812003.1	biological_process	GO:0061172	regulation of establishment of bipolar cell polarity	"Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw]	PANTHER
NV2t007812003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007813001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t007813001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007813001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t007813001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t007815001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t007815001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t007815001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t007815001.1	biological_process	GO:0017196	N-terminal peptidyl-methionine acetylation	"The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]	OMA
NV2t007815001.1	biological_process	GO:0017196	N-terminal peptidyl-methionine acetylation	"The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]	PANTHER
NV2t007815001.1	biological_process	GO:0043966	obsolete histone H3 acetylation	"OBSOLETE. The modification of histone H3 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t007815001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t007815001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t007815001.1	molecular_function	GO:0004596	peptide alpha-N-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [GOC:mah, PMID:30054468]	OMA
NV2t007815001.1	molecular_function	GO:0010485	histone H4 acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48]	OMA
NV2t007815001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t007815001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t007818001.1	biological_process	GO:0046900	tetrahydrofolylpolyglutamate metabolic process	"The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t007818001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t007818001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	InterPro
NV2t007818001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t007818001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007818002.1	biological_process	GO:0046900	tetrahydrofolylpolyglutamate metabolic process	"The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t007818002.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	InterPro
NV2t007819001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007819001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t007819001.1	cellular_component	GO:0097431	mitotic spindle pole	"Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]	OMA
NV2t007819001.1	cellular_component	GO:0097431	mitotic spindle pole	"Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]	PANTHER
NV2t007819001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007819001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t007820001.1	biological_process	GO:0006545	glycine biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators]	OMA
NV2t007820001.1	biological_process	GO:0009068	aspartate family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t007820001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007820001.1	molecular_function	GO:0008732	L-allo-threonine aldolase activity	"Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [PMID:9228760, RHEA:26209]	PANTHER
NV2t007820001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t007820001.1	molecular_function	GO:0016832	aldehyde-lyase activity	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators]	OMA
NV2t007821001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t007821001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t007821001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t007821001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t007821001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007821001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t007821001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t007821001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t007823001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t007823001.1	biological_process	GO:0051725	protein de-ADP-ribosylation	"The process of removing one or more ADP-ribose residues from a protein." [GOC:ai]	InterPro
NV2t007823001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007823001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t007823001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	OMA
NV2t007824001.1	molecular_function	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]	OMA
NV2t007824001.1	molecular_function	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]	PANTHER
NV2t007825001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t007827001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t007827001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t007827001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007827002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t007827002.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t007827002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007827003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t007827003.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t007827003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007828001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t007832001.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t007832001.1	biological_process	GO:0019264	glycine biosynthetic process from serine	"The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators]	OMA
NV2t007832001.1	biological_process	GO:0035999	tetrahydrofolate interconversion	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999]	InterPro
NV2t007832001.1	biological_process	GO:0046653	tetrahydrofolate metabolic process	"The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	OMA
NV2t007832001.1	molecular_function	GO:0004372	glycine hydroxymethyltransferase activity	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [RHEA:15481]	OMA
NV2t007832001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007832001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t007832001.1	molecular_function	GO:0070905	serine binding	"Binding to 2-amino-3-hydroxypropanoic acid." [GOC:rph]	PANTHER
NV2t007832002.1	biological_process	GO:0035999	tetrahydrofolate interconversion	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999]	InterPro
NV2t007832002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007832002.1	molecular_function	GO:0070905	serine binding	"Binding to 2-amino-3-hydroxypropanoic acid." [GOC:rph]	PANTHER
NV2t007832003.1	biological_process	GO:0035999	tetrahydrofolate interconversion	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999]	InterPro
NV2t007832003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007832003.1	molecular_function	GO:0070905	serine binding	"Binding to 2-amino-3-hydroxypropanoic acid." [GOC:rph]	PANTHER
NV2t007832004.1	biological_process	GO:0035999	tetrahydrofolate interconversion	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999]	InterPro
NV2t007832004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t007832004.1	molecular_function	GO:0070905	serine binding	"Binding to 2-amino-3-hydroxypropanoic acid." [GOC:rph]	PANTHER
NV2t007833001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t007833001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t007833001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t007834001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	InterPro
NV2t007834002.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	InterPro
NV2t007835001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007835002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007835002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t007835003.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t007835003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007835003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t007835004.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t007835004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t007836001.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t007836001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007837001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007837001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t007837001.1	molecular_function	GO:0140663	ATP-dependent FeS chaperone activity	"Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis." [PMID:16843540]	InterPro
NV2t007838001.1	biological_process	GO:0006537	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t007838001.1	biological_process	GO:0006537	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	PANTHER
NV2t007838001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007838001.1	molecular_function	GO:0004353	glutamate dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3]	OMA
NV2t007838001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007838001.1	molecular_function	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	InterPro
NV2t007838002.1	biological_process	GO:0006537	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	PANTHER
NV2t007838002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007838002.1	molecular_function	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	InterPro
NV2t007838003.1	biological_process	GO:0006537	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	PANTHER
NV2t007838003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007838003.1	molecular_function	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	InterPro
NV2t007838004.1	biological_process	GO:0006537	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	PANTHER
NV2t007838004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007838004.1	molecular_function	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	InterPro
NV2t007838005.1	biological_process	GO:0006537	glutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	PANTHER
NV2t007838005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007838005.1	molecular_function	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	InterPro
NV2t007839001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t007839001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007839001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007842001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t007845001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t007845001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t007845001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t007845001.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	OMA
NV2t007845001.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	PANTHER
NV2t007848001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t007848001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007848001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007850001.1	biological_process	GO:0030322	stabilization of membrane potential	"The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t007850001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t007850001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007850001.1	molecular_function	GO:0015271	outward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]	OMA
NV2t007850001.1	molecular_function	GO:0022841	potassium ion leak channel activity	"Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t007852001.1	biological_process	GO:0043461	proton-transporting ATP synthase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]	InterPro
NV2t007852002.1	biological_process	GO:0043461	proton-transporting ATP synthase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]	InterPro
NV2t007852003.1	biological_process	GO:0043461	proton-transporting ATP synthase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]	InterPro
NV2t007852004.1	biological_process	GO:0043461	proton-transporting ATP synthase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]	InterPro
NV2t007856001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t007856002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t007857001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t007859001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t007864001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t007864001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t007864001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007865001.1	biological_process	GO:0002092	positive regulation of receptor internalization	"Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd]	OMA
NV2t007865001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t007865001.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	OMA
NV2t007865001.1	biological_process	GO:0043113	receptor clustering	"The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]	OMA
NV2t007865001.1	biological_process	GO:0043113	receptor clustering	"The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]	PANTHER
NV2t007865001.1	biological_process	GO:0097062	dendritic spine maintenance	"The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104]	OMA
NV2t007865001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t007865001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t007865001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t007865001.1	cellular_component	GO:0032588	trans-Golgi network membrane	"The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]	OMA
NV2t007865001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t007865001.1	molecular_function	GO:0005080	protein kinase C binding	"Binding to protein kinase C." [GOC:jl]	OMA
NV2t007865001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007865001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t007865001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t007865001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t007867001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t007867001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007869001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t007869001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t007869001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t007869001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007869001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007871001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t007871001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t007871001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t007871001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	OMA
NV2t007871001.1	biological_process	GO:0070462	plus-end specific microtubule depolymerization	"The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148]	OMA
NV2t007871001.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t007871001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t007871001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t007871001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t007871001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007871001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t007871001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t007871001.1	molecular_function	GO:0008574	plus-end-directed microtubule motor activity	"A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis." [GOC:vw, PMID:32842864]	OMA
NV2t007871001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t007872001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007872001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t007872001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t007872001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t007872002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t007872002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t007873001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t007873001.1	biological_process	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t007873001.1	biological_process	GO:0009205	purine ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t007873001.1	biological_process	GO:0061014	positive regulation of mRNA catabolic process	"Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t007873001.1	cellular_component	GO:0000178	exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t007873001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007873001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t007873001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t007873001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007873001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007875001.1	biological_process	GO:0045721	negative regulation of gluconeogenesis	"Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]	PANTHER
NV2t007876001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t007878001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t007878001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t007878001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t007878001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t007878001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007878001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007880001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t007880001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t007880001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t007880001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007880001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t007880001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t007880001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007880001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007883001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007884001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t007884001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t007884001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t007884001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t007884001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007884001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007885001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007885001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t007885001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t007885001.1	molecular_function	GO:0004708	MAP kinase kinase activity	"Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684]	PANTHER
NV2t007885001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007886001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t007886001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t007886001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t007886001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t007886001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t007886001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t007890001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t007890001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t007890001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007890002.1	biological_process	GO:0000380	alternative mRNA splicing, via spliceosome	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]	OMA
NV2t007890002.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t007890002.1	biological_process	GO:0010556	regulation of macromolecule biosynthetic process	"Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t007890002.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t007890002.1	biological_process	GO:0031326	regulation of cellular biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t007890002.1	biological_process	GO:0034470	obsolete ncRNA processing	"OBSOLETE. Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah, PMID:27573892]	OMA
NV2t007890002.1	biological_process	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	OMA
NV2t007890002.1	biological_process	GO:1903311	regulation of mRNA metabolic process	"Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t007890002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007890002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t007890002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t007890002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007890002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t007890002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t007890002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007890002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007890003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t007890003.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t007890003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007890004.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t007890004.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t007890004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007891001.1	biological_process	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t007891001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t007891001.1	biological_process	GO:0032008	positive regulation of TOR signaling	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t007891001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t007891001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t007891001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	OMA
NV2t007891001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	PANTHER
NV2t007891001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t007891001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t007891001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t007892001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t007892001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007894001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007894001.1	molecular_function	GO:0050038	L-xylulose reductase (NADPH) activity	"Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH." [EC:1.1.1.10, RHEA:17025]	PANTHER
NV2t007894002.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t007894002.1	biological_process	GO:0019321	pentose metabolic process	"The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t007894002.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t007894002.1	molecular_function	GO:0004090	carbonyl reductase (NADPH) activity	"Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]	OMA
NV2t007894002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007894002.1	molecular_function	GO:0050038	L-xylulose reductase (NADPH) activity	"Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH." [EC:1.1.1.10, RHEA:17025]	PANTHER
NV2t007895001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t007895001.1	biological_process	GO:0070192	chromosome organization involved in meiotic cell cycle	"A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah]	PANTHER
NV2t007895001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t007895001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t007895001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007895001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t007895001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t007895001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t007895002.1	biological_process	GO:0070192	chromosome organization involved in meiotic cell cycle	"A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah]	PANTHER
NV2t007895002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t007895002.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t007896001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007896002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007896002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007896002.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t007896002.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	OMA
NV2t007897001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007897001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t007897001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t007898001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t007898001.1	biological_process	GO:0019359	nicotinamide nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]	OMA
NV2t007898001.1	biological_process	GO:0019441	tryptophan catabolic process to kynurenine	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]	OMA
NV2t007898001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t007898001.1	biological_process	GO:0034354	'de novo' NAD biosynthetic process from tryptophan	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604]	PANTHER
NV2t007898001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007898001.1	molecular_function	GO:0004833	tryptophan 2,3-dioxygenase activity	"Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11]	OMA
NV2t007898001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t007898001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t007898001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007898001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t007898002.1	biological_process	GO:0034354	'de novo' NAD biosynthetic process from tryptophan	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604]	PANTHER
NV2t007898002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t007898002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007899001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t007903001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t007903001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t007903001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007905001.1	biological_process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	"An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs." [PMID:14744438, PMID:15196554]	OMA
NV2t007905001.1	biological_process	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]	OMA
NV2t007905001.1	biological_process	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]	PANTHER
NV2t007905001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t007905001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t007905001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007905001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007909001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t007910001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t007910001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t007910001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t007910001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	PANTHER
NV2t007910001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t007910001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t007910001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t007912001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t007912001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007912001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t007915001.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	PANTHER
NV2t007918001.1	biological_process	GO:0110155	NAD-cap decapping	"Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes." [GOC:sp, PMID:25533955, PMID:28283058, PMID:31101919]	PANTHER
NV2t007919001.1	biological_process	GO:0110155	NAD-cap decapping	"Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes." [GOC:sp, PMID:25533955, PMID:28283058, PMID:31101919]	PANTHER
NV2t007920001.1	biological_process	GO:0110155	NAD-cap decapping	"Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes." [GOC:sp, PMID:25533955, PMID:28283058, PMID:31101919]	PANTHER
NV2t007925005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t007925005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007928001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t007928001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t007928001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007928001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007930001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t007930001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007930001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t007930001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t007932001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t007932001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007932001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t007932001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007932001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t007932001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t007932001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t007932002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t007932002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t007934001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t007934001.1	biological_process	GO:0046483	obsolete heterocycle metabolic process	"OBSOLETE. The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732]	OMA
NV2t007934001.1	biological_process	GO:1901360	organic cyclic compound metabolic process	"The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]	OMA
NV2t007934001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t007934001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007934001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t007934001.1	molecular_function	GO:0045174	glutathione dehydrogenase (ascorbate) activity	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424]	OMA
NV2t007934001.1	molecular_function	GO:0045174	glutathione dehydrogenase (ascorbate) activity	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424]	PANTHER
NV2t007934002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t007934002.1	molecular_function	GO:0045174	glutathione dehydrogenase (ascorbate) activity	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424]	PANTHER
NV2t007935001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t007935001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t007935001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007935001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t007935001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t007935001.1	cellular_component	GO:1990604	IRE1-TRAF2-ASK1 complex	"A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K)." [GOC:bf, GOC:PARL, PMID:12050113, PMID:23000344]	PANTHER
NV2t007935001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t007935001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t007935001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007935001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007936001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t007936001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t007936001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	PANTHER
NV2t007937001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t007937001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t007937001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007937001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t007937001.1	cellular_component	GO:0061574	ASAP complex	"A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1." [GOC:dph, PMID:12665594, PMID:16314458, PMID:22388736]	PANTHER
NV2t007937001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007937001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t007937001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t007938001.1	biological_process	GO:0006725	obsolete cellular aromatic compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732]	OMA
NV2t007938001.1	biological_process	GO:0009308	amine metabolic process	"The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]	OMA
NV2t007938001.1	biological_process	GO:0042446	hormone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t007938001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t007938001.1	biological_process	GO:0046483	obsolete heterocycle metabolic process	"OBSOLETE. The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732]	OMA
NV2t007938001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t007938001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007938001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	OMA
NV2t007938001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	PANTHER
NV2t007945001.1	biological_process	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]	OMA
NV2t007945001.1	biological_process	GO:1901360	organic cyclic compound metabolic process	"The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]	OMA
NV2t007945001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t007945001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t007945001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t007945001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t007945001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t007945001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t007945001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t007946001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t007946001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t007946001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	PANTHER
NV2t007948001.1	cellular_component	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t007948001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t007948001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007950001.1	biological_process	GO:0034765	regulation of monoatomic ion transmembrane transport	"Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]	OMA
NV2t007950001.1	biological_process	GO:0098659	inorganic cation import across plasma membrane	"The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t007950001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t007950001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007950001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t007950001.1	molecular_function	GO:0005242	inward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]	OMA
NV2t007952001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007952002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007955001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007955001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t007955001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t007955001.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	OMA
NV2t007955001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t007955001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007955001.1	molecular_function	GO:0004697	diacylglycerol-dependent serine/threonine kinase activity	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]	OMA
NV2t007955001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007955001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t007955001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007955001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007955002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007955002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007955002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007955002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007955003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007955003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007955003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007955003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007955004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007955004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007955004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007955004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007955005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007955005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t007955005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007955005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007955006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007955006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007955006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007955006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007955007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007955007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007955007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007955007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007955008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007955008.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t007955008.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007955008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007956001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t007956001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t007956002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t007956002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t007958001.1	biological_process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	"Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation." [GOC:BHF]	PANTHER
NV2t007958001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t007960001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t007960001.1	biological_process	GO:0043401	steroid hormone mediated signaling pathway	"The series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	OMA
NV2t007960001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007960001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t007960001.1	molecular_function	GO:0005496	steroid binding	"Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732]	OMA
NV2t007960001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t007960001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t007960001.1	molecular_function	GO:0034056	estrogen response element binding	"Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005]	PANTHER
NV2t007960001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t007960001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t007960001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t007961001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t007961001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t007961002.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t007961002.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t007961003.1	biological_process	GO:0006778	porphyrin-containing compound metabolic process	"The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]	OMA
NV2t007961003.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t007961003.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t007961003.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t007961003.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t007961003.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t007961003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t007961003.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t007961003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t007961003.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t007961003.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t007961003.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t007961003.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t007961004.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t007961004.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t007961005.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t007961005.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t007961005.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t007965001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007973001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t007973001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t007973001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t007973001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t007974001.1	biological_process	GO:0006744	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	InterPro
NV2t007974001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t007974001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t007974001.1	molecular_function	GO:0008682	3-demethoxyubiquinol 3-hydroxylase activity	"Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O." [RHEA:50908]	PANTHER
NV2t007975001.1	biological_process	GO:0046900	tetrahydrofolylpolyglutamate metabolic process	"The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t007975001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	InterPro
NV2t007976001.1	biological_process	GO:0006760	folic acid-containing compound metabolic process	"The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah]	OMA
NV2t007976001.1	biological_process	GO:0046900	tetrahydrofolylpolyglutamate metabolic process	"The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t007976001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t007976001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t007976001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	InterPro
NV2t007976001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t007976001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t007978001.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	InterPro
NV2t007978001.1	cellular_component	GO:1990130	GATOR1 complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]	PANTHER
NV2t007978002.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	InterPro
NV2t007978002.1	cellular_component	GO:1990130	GATOR1 complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]	PANTHER
NV2t007978003.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	InterPro
NV2t007978003.1	cellular_component	GO:1990130	GATOR1 complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]	PANTHER
NV2t007978004.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	InterPro
NV2t007978004.1	cellular_component	GO:1990130	GATOR1 complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]	PANTHER
NV2t007979001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t007979001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t007980001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	PANTHER
NV2t007981001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007981001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007981001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007981001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007981002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t007981002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t007981002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007981002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t007981003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t007982001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t007982001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t007982001.1	molecular_function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	"Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai]	PANTHER
NV2t007983001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t007983001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	PANTHER
NV2t007983001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t007983001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t007983001.1	biological_process	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t007983001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t007983001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t007983001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t007983001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t007983001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t007984001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t007984001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t007985001.1	biological_process	GO:0031623	receptor internalization	"A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]	OMA
NV2t007985001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t007985001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t007985001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t007985001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t007985001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t007985001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t007988001.1	biological_process	GO:0009231	riboflavin biosynthetic process	"The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]	InterPro
NV2t007988001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t007988001.1	biological_process	GO:0042364	water-soluble vitamin biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl]	OMA
NV2t007988001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t007988001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t007988001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t007988001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t007989001.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	PANTHER
NV2t007990001.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	PANTHER
NV2t007991001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t007991001.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t007991001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t007991001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	OMA
NV2t007991001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t007991001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t007991001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t007991001.1	cellular_component	GO:0030877	beta-catenin destruction complex	"A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]	OMA
NV2t007991001.1	molecular_function	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	OMA
NV2t007991001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t007991001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t007991001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t007994001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t007994001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t007994001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t007994001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t007994001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t007994001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t007994001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t007994001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t007994001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t007995001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t007995001.1	biological_process	GO:0046340	diacylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11717312]	PANTHER
NV2t007995002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t007995002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t007995002.1	biological_process	GO:0046340	diacylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11717312]	PANTHER
NV2t007999001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t008000001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	OMA
NV2t008000001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008000001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008003001.1	biological_process	GO:0009141	nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008003001.1	biological_process	GO:1901292	nucleoside phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie]	OMA
NV2t008003001.1	molecular_function	GO:0047429	nucleoside triphosphate diphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]	InterPro
NV2t008003001.1	molecular_function	GO:0047429	nucleoside triphosphate diphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]	OMA
NV2t008003001.1	molecular_function	GO:0047840	dCTP diphosphatase activity	"Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate." [RHEA:22636]	PANTHER
NV2t008006001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t008006001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t008007001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008007002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008008001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008008001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t008009001.1	biological_process	GO:1903632	obsolete positive regulation of aminoacyl-tRNA ligase activity	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766]	PANTHER
NV2t008009001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t008011001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008011001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t008012001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t008014001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008014001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008015001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t008015002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t008015003.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t008016001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t008016001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t008016001.1	biological_process	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	OMA
NV2t008016001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t008016001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	OMA
NV2t008016001.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t008016001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t008016001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t008016001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t008016001.1	cellular_component	GO:0034456	UTP-C complex	"A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605]	PANTHER
NV2t008016001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t008016001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t008016001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008016001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008016001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t008017001.1	biological_process	GO:0034394	protein localization to cell surface	"A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]	PANTHER
NV2t008017001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t008017002.1	biological_process	GO:0034394	protein localization to cell surface	"A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]	PANTHER
NV2t008017002.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t008017003.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t008017003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t008017003.1	biological_process	GO:0034394	protein localization to cell surface	"A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]	OMA
NV2t008017003.1	biological_process	GO:0034394	protein localization to cell surface	"A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]	PANTHER
NV2t008017003.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t008017003.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	OMA
NV2t008017003.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t008017003.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t008017003.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t008017003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t008017003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t008017003.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t008017003.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t008018001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t008018001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008018001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008018001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008018002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008021001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008021001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008021001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008022001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t008022001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008022001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t008022001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t008022001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t008022001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t008022001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t008024001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024003.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024004.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024005.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024006.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024006.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024006.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024007.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024007.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024007.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024008.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024008.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024008.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024009.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008024009.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008024009.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024010.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024010.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t008024010.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024011.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024011.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024012.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024012.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024013.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024014.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024014.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024015.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008024015.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008024016.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008025001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t008025001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008027001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t008027001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t008027001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008027001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008027002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008027002.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t008027002.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t008027002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t008027002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t008027002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t008027002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t008027002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008027002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008027002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008029001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008029001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008029001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t008029001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008029001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008029002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008029002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008029002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008030001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t008030002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t008030004.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t008031001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	OMA
NV2t008031001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008031001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008031001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t008031001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t008031001.1	molecular_function	GO:0016842	amidine-lyase activity	"Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]	OMA
NV2t008031001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008031001.1	molecular_function	GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity	"Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [GOC:mah, GOC:pde]	PANTHER
NV2t008032001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t008032001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008032001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008032002.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	InterPro
NV2t008032002.1	cellular_component	GO:1990498	mitotic spindle microtubule	"Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw]	PANTHER
NV2t008032003.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	InterPro
NV2t008032003.1	cellular_component	GO:1990498	mitotic spindle microtubule	"Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw]	PANTHER
NV2t008033001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t008033001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008033001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008033001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t008034001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008035001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t008035001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t008035001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008035001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t008035001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	OMA
NV2t008037001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t008037001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t008037001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t008037001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t008037001.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	OMA
NV2t008037001.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	PANTHER
NV2t008037001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008037001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t008037001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t008037001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008037001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t008038001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t008038001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008042001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t008042001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t008042001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t008042001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t008042001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t008043001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t008043001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008043001.1	molecular_function	GO:0016530	metallochaperone activity	"Binding to and delivering metal ions to a target protein." [PMID:11739376]	OMA
NV2t008043001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t008043001.1	molecular_function	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	OMA
NV2t008043001.1	molecular_function	GO:0140663	ATP-dependent FeS chaperone activity	"Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis." [PMID:16843540]	InterPro
NV2t008043002.1	molecular_function	GO:0140663	ATP-dependent FeS chaperone activity	"Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis." [PMID:16843540]	InterPro
NV2t008044001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008044001.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t008044002.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t008047001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t008047001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t008047001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008047001.1	molecular_function	GO:0005261	monoatomic cation channel activity	"Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008051001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t008051001.1	cellular_component	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	OMA
NV2t008051001.1	molecular_function	GO:0030619	U1 snRNA binding	"Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah]	OMA
NV2t008051001.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	OMA
NV2t008051001.1	molecular_function	GO:0030620	U2 snRNA binding	"Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl]	PANTHER
NV2t008052001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t008052001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t008052001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t008052001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t008052001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t008052001.1	molecular_function	GO:0072341	modified amino acid binding	"Binding to a modified amino acid." [GOC:mah]	OMA
NV2t008052001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t008052001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t008053001.1	biological_process	GO:0000712	resolution of meiotic recombination intermediates	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]	OMA
NV2t008053001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t008053001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t008053001.1	biological_process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]	OMA
NV2t008053001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008053001.1	cellular_component	GO:0048476	Holliday junction resolvase complex	"An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated." [PMID:11207366, PMID:12374758]	InterPro
NV2t008053001.1	cellular_component	GO:1905348	endonuclease complex	"A protein complex which is capable of endonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]	OMA
NV2t008053001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008053001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t008053001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	OMA
NV2t008054001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t008055001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	InterPro
NV2t008055001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008055001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008055002.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	InterPro
NV2t008055002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008055002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008056001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t008056001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t008056001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t008056001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t008061001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008067001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t008085001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t008085001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008085001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008085001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008086001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t008086001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008086001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008087001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t008088001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t008088002.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t008088002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t008088003.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t008088004.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t008089001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t008089001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t008089001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t008089001.1	molecular_function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	PANTHER
NV2t008089002.1	cellular_component	GO:0045095	keratin filament	"A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363]	InterPro
NV2t008089003.1	cellular_component	GO:0045095	keratin filament	"A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363]	InterPro
NV2t008091001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t008091001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t008091001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t008091001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t008091001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t008091002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t008091003.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t008092001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	OMA
NV2t008092001.1	cellular_component	GO:0032299	ribonuclease H2 complex	"A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815]	InterPro
NV2t008092001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t008092001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t008093002.1	cellular_component	GO:0097539	ciliary transition fiber	"A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium)." [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827]	InterPro
NV2t008093003.1	cellular_component	GO:0097539	ciliary transition fiber	"A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium)." [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827]	InterPro
NV2t008096001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t008096002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t008097001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008097002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008097003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008097004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008097006.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t008097006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008098001.1	biological_process	GO:1901987	regulation of cell cycle phase transition	"Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]	PANTHER
NV2t008102001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t008103002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103007.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t008103007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103009.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t008103009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103010.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t008103010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103015.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103018.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103019.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103020.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103021.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103022.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103023.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008103024.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008108001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t008108001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t008108001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008108001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008108001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008108001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t008108001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008108001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t008108002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008108002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008108002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008109001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	PANTHER
NV2t008109001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008109001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008109001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008109002.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	PANTHER
NV2t008109002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008109002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008109002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008109003.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	PANTHER
NV2t008109003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008109003.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008109003.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008110001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008110001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008110001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008110002.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t008110002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008110002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008110002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008110002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t008110002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008110002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t008112001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	PANTHER
NV2t008112001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t008112001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008112001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008112001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008112001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t008112001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008112001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t008112002.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	PANTHER
NV2t008112002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008112002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t008112002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008115001.1	biological_process	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	InterPro
NV2t008115001.1	biological_process	GO:0043137	DNA replication, removal of RNA primer	"Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238]	PANTHER
NV2t008115001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008115001.1	molecular_function	GO:0004523	RNA-DNA hybrid ribonuclease activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	InterPro
NV2t008120001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t008120001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008122001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t008122001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008122001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008124001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t008124001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	OMA
NV2t008124001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t008126001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t008126001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t008126001.1	biological_process	GO:0019985	translesion synthesis	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]	OMA
NV2t008126001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t008126001.1	cellular_component	GO:0016035	zeta DNA polymerase complex	"A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464]	OMA
NV2t008126001.1	cellular_component	GO:0043625	delta DNA polymerase complex	"A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]	OMA
NV2t008126001.1	cellular_component	GO:0043625	delta DNA polymerase complex	"A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]	PANTHER
NV2t008126001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008126001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t008126001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t008128001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008128002.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008128003.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008128004.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008128005.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008128006.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t008128006.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t008128006.1	biological_process	GO:1905793	protein localization to pericentriolar material	"A process in which a protein is transported to, or maintained in, a location within a pericentriolar material." [GO_REF:0000087, GOC:TermGenie, PMID:21694707, PMID:24385583]	OMA
NV2t008128006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008128006.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t008128006.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t008128006.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008128007.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008128008.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008132001.1	biological_process	GO:0005996	monosaccharide metabolic process	"The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732]	OMA
NV2t008132001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t008132001.1	biological_process	GO:0006767	water-soluble vitamin metabolic process	"The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl]	OMA
NV2t008132001.1	biological_process	GO:0006805	xenobiotic metabolic process	"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc]	OMA
NV2t008132001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t008132001.1	biological_process	GO:0046483	obsolete heterocycle metabolic process	"OBSOLETE. The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732]	OMA
NV2t008132001.1	biological_process	GO:0071243	cellular response to arsenic-containing substance	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah]	OMA
NV2t008132001.1	biological_process	GO:1901360	organic cyclic compound metabolic process	"The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]	OMA
NV2t008132001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t008132001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008132001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t008132001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008132001.1	molecular_function	GO:0045174	glutathione dehydrogenase (ascorbate) activity	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424]	OMA
NV2t008132001.1	molecular_function	GO:0045174	glutathione dehydrogenase (ascorbate) activity	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424]	PANTHER
NV2t008134001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008134001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008134001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t008134001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t008136001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008136002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008136003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008136003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008136003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008136003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008136003.1	molecular_function	GO:0035035	histone acetyltransferase binding	"Binding to an histone acetyltransferase." [GOC:bf]	OMA
NV2t008136004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008137001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t008137001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t008137001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t008137001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t008137001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t008137001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t008137001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t008138001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t008138002.1	molecular_function	GO:0009882	blue light photoreceptor activity	"The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb]	OMA
NV2t008138002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t008138002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t008149001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008149001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t008153001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008162001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t008162001.1	biological_process	GO:0070813	hydrogen sulfide metabolic process	"The chemical reactions and pathways involving hydrogen sulfide, H2S." [GOC:mah]	PANTHER
NV2t008162001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t008162001.1	molecular_function	GO:0050313	sulfur dioxygenase activity	"Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+." [EC:1.13.11.18]	InterPro
NV2t008163001.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t008163001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t008163001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008163001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t008163001.1	biological_process	GO:0046685	response to arsenic-containing substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544]	OMA
NV2t008163001.1	biological_process	GO:0046686	response to cadmium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai]	OMA
NV2t008163001.1	cellular_component	GO:0000152	nuclear ubiquitin ligase complex	"A ubiquitin ligase complex found in the nucleus." [GOC:mah]	OMA
NV2t008163001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t008163001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008163001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008163001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t008163001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t008165001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008165001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t008165001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t008167001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008167001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008167001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008167001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t008168001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t008173002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t008174001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t008174001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t008174001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t008176001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t008176001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008176002.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t008176002.1	biological_process	GO:0007605	sensory perception of sound	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]	OMA
NV2t008176002.1	biological_process	GO:0030048	actin filament-based movement	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]	OMA
NV2t008176002.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t008176002.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	OMA
NV2t008176002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t008176002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008176002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t008176002.1	cellular_component	GO:0098858	actin-based cell projection	"A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]	OMA
NV2t008176002.1	molecular_function	GO:0000146	microfilament motor activity	"A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]	OMA
NV2t008176002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008176002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008176002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t008176003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t008176003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008178001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t008178001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	InterPro
NV2t008178001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t008178001.1	biological_process	GO:0010508	positive regulation of autophagy	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t008178001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t008178001.1	biological_process	GO:1903059	regulation of protein lipidation	"Any process that modulates the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]	OMA
NV2t008178001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t008178001.1	cellular_component	GO:1990316	Atg1/ULK1 kinase complex	"A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]	OMA
NV2t008178001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008178001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t008179001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t008255001.1	biological_process	GO:0010960	magnesium ion homeostasis	"Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb]	InterPro
NV2t008255001.1	biological_process	GO:0010960	magnesium ion homeostasis	"Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb]	OMA
NV2t008257001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t008262001.1	biological_process	GO:0090251	protein localization involved in establishment of planar polarity	"Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t008262001.1	biological_process	GO:0090251	protein localization involved in establishment of planar polarity	"Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t008262001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008262001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t008262001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008263001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008263001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t008263001.1	biological_process	GO:0045786	negative regulation of cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t008263001.1	biological_process	GO:0045786	negative regulation of cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t008263001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008264001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	InterPro
NV2t008264001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008264001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t008265001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008265001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t008265001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t008265001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t008265001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008265001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008265001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008267001.1	biological_process	GO:1903478	obsolete actin filament bundle convergence involved in mitotic contractile ring assembly	"OBSOLETE. Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]	PANTHER
NV2t008267001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267002.1	biological_process	GO:1903478	obsolete actin filament bundle convergence involved in mitotic contractile ring assembly	"OBSOLETE. Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]	PANTHER
NV2t008267002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267004.1	biological_process	GO:1903478	obsolete actin filament bundle convergence involved in mitotic contractile ring assembly	"OBSOLETE. Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]	PANTHER
NV2t008267004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267005.1	biological_process	GO:1903478	obsolete actin filament bundle convergence involved in mitotic contractile ring assembly	"OBSOLETE. Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]	PANTHER
NV2t008267005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267006.1	biological_process	GO:1903478	obsolete actin filament bundle convergence involved in mitotic contractile ring assembly	"OBSOLETE. Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]	PANTHER
NV2t008267006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267007.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008267008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267008.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008267009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267009.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008267010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267010.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008267011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267011.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008267012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008267012.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008268001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008268002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008268003.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	PANTHER
NV2t008270001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t008270001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t008270001.1	biological_process	GO:1901522	obsolete positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	"OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus." [GOC:TermGenie, PMID:22840777]	OMA
NV2t008270001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t008270001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t008270001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	InterPro
NV2t008270001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t008271001.1	molecular_function	GO:0004064	arylesterase activity	"Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]	InterPro
NV2t008271002.1	biological_process	GO:0009636	response to toxic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr]	OMA
NV2t008271002.1	biological_process	GO:0019439	obsolete aromatic compound catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t008271002.1	biological_process	GO:0032370	positive regulation of lipid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t008271002.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t008271002.1	biological_process	GO:0032411	positive regulation of transporter activity	"Any process that activates or increases the activity of a transporter." [GOC:mah]	OMA
NV2t008271002.1	biological_process	GO:0046395	carboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t008271002.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t008271002.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t008271002.1	biological_process	GO:0051099	positive regulation of binding	"Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]	OMA
NV2t008271002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t008271002.1	cellular_component	GO:0032994	protein-lipid complex	"A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." [GOC:mah]	OMA
NV2t008271002.1	molecular_function	GO:0004064	arylesterase activity	"Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]	InterPro
NV2t008271002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008271002.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t008271002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t008271002.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t008271002.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t008271003.1	molecular_function	GO:0004064	arylesterase activity	"Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]	InterPro
NV2t008273001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t008273001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t008273001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t008273001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t008273001.1	biological_process	GO:0045324	late endosome to vacuole transport	"The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]	PANTHER
NV2t008273001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t008273001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t008273001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t008273001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t008274001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t008274001.1	biological_process	GO:0006436	tryptophanyl-tRNA aminoacylation	"The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t008274001.1	biological_process	GO:0006436	tryptophanyl-tRNA aminoacylation	"The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	OMA
NV2t008274001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t008274001.1	biological_process	GO:0070127	tRNA aminoacylation for mitochondrial protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah]	OMA
NV2t008274001.1	biological_process	GO:0070183	mitochondrial tryptophanyl-tRNA aminoacylation	"The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]	PANTHER
NV2t008274001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t008274001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t008274001.1	molecular_function	GO:0004830	tryptophan-tRNA ligase activity	"Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]	InterPro
NV2t008274001.1	molecular_function	GO:0004830	tryptophan-tRNA ligase activity	"Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]	OMA
NV2t008274001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008276001.1	biological_process	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	PANTHER
NV2t008276001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t008276001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t008278001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t008280001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008280001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008280002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008284001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t008284001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t008284001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t008289001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t008292001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t008292001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	PANTHER
NV2t008292001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008292002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008292002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008293001.1	biological_process	GO:0006570	tyrosine metabolic process	"The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]	OMA
NV2t008293001.1	biological_process	GO:0006575	cellular modified amino acid metabolic process	"The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t008293001.1	biological_process	GO:0018958	phenol-containing compound metabolic process	"The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]	OMA
NV2t008293001.1	biological_process	GO:0042445	hormone metabolic process	"The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t008293001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008293001.1	cellular_component	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	OMA
NV2t008293001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t008293001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008293001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t008293001.1	molecular_function	GO:0140616	iodotyrosine deiodinase activity	"Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates." [PMID:15289438, PMID:18434651, PMID:25395621, PMID:27643701, RHEA:32479]	OMA
NV2t008294001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008294001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008294001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008294001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008295001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008295002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008295003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008296001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008296001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008297001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008299001.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t008299001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008299001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008299002.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t008299002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008299002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008299003.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t008299003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008299003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008299004.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t008299004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008299004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008299004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008299005.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t008299005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008299005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008300001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008301001.1	biological_process	GO:0023041	neuronal signal transduction	"The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal]	OMA
NV2t008301001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t008301001.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t008301001.1	cellular_component	GO:0030867	rough endoplasmic reticulum membrane	"The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah]	InterPro
NV2t008301001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t008301002.1	cellular_component	GO:0030867	rough endoplasmic reticulum membrane	"The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah]	InterPro
NV2t008301003.1	cellular_component	GO:0030867	rough endoplasmic reticulum membrane	"The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah]	InterPro
NV2t008303001.1	cellular_component	GO:0045272	plasma membrane respiratory chain complex I	"A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t008303001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t008303001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t008303001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t008303001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t008303001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t008303001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t008304001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t008304001.1	molecular_function	GO:0004559	alpha-mannosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]	OMA
NV2t008304001.1	molecular_function	GO:0016798	hydrolase activity, acting on glycosyl bonds	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]	InterPro
NV2t008304002.1	molecular_function	GO:0016798	hydrolase activity, acting on glycosyl bonds	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]	InterPro
NV2t008305001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t008305001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t008305001.1	cellular_component	GO:1990071	TRAPPII protein complex	"A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]	InterPro
NV2t008305001.1	cellular_component	GO:1990071	TRAPPII protein complex	"A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]	OMA
NV2t008307001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008307001.1	biological_process	GO:0031293	membrane protein intracellular domain proteolysis	"The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018]	OMA
NV2t008307001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t008307001.1	biological_process	GO:0036003	obsolete positive regulation of transcription from RNA polymerase II promoter in response to stress	"OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mcc]	OMA
NV2t008307001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t008307001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t008307001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t008307001.1	biological_process	GO:0071695	anatomical structure maturation	"A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]	OMA
NV2t008307001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t008307001.1	biological_process	GO:1990440	obsolete positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145]	PANTHER
NV2t008307001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008307001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008307001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008307001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t008307001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008308001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t008308001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t008310001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t008310001.1	biological_process	GO:0051282	regulation of sequestering of calcium ion	"Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]	OMA
NV2t008310001.1	biological_process	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	"Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]	OMA
NV2t008310001.1	biological_process	GO:2001258	negative regulation of cation channel activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity." [GOC:BHF]	OMA
NV2t008310001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008310001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008310001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008310001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008311002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t008311003.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t008311003.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t008311003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008311003.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t008311003.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t008311004.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t008312001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t008312001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t008312001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008312001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008314001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008314001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008314001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008314001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t008317001.1	biological_process	GO:0002804	positive regulation of antifungal peptide production	"Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add]	OMA
NV2t008317001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008317001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008317001.1	biological_process	GO:0006963	positive regulation of antibacterial peptide biosynthetic process	"Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]	OMA
NV2t008317001.1	biological_process	GO:0035008	positive regulation of melanization defense response	"Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf]	OMA
NV2t008317001.1	biological_process	GO:0050830	defense response to Gram-positive bacterium	"Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]	OMA
NV2t008317001.1	biological_process	GO:0061760	antifungal innate immune response	"An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:dph, PMID:22470487]	OMA
NV2t008317001.1	biological_process	GO:0071219	cellular response to molecule of bacterial origin	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:mah]	OMA
NV2t008317001.1	biological_process	GO:0160032	Toll receptor ligand protein activation cascade	"A protein activation cascade that generates the active Toll receptor ligand and consists of the cascade of enzymatic reactions initiated by extracellular recognition factors, leading to the cleavage of the inactive form of spatzle family of ligands." [PMID:23632253]	OMA
NV2t008317001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t008317001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t008320001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	PANTHER
NV2t008320001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t008320002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008320002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008320002.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t008320002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008320002.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	PANTHER
NV2t008320002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t008320002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t008321001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t008322001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t008322001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t008322001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t008322001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t008322001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t008322001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t008322001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t008322001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t008323001.1	biological_process	GO:0097720	calcineurin-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]	PANTHER
NV2t008323001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008324001.1	biological_process	GO:0009880	embryonic pattern specification	"The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]	PANTHER
NV2t008325001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t008325001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t008325001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t008325001.1	molecular_function	GO:0018271	biotin-protein ligase activity	"Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah]	OMA
NV2t008327001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t008331001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t008331001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008331001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008331001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008332001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008332001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t008332001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008332001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t008332001.1	biological_process	GO:0060284	regulation of cell development	"Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]	OMA
NV2t008332001.1	biological_process	GO:0090308	regulation of DNA methylation-dependent heterochromatin formation	"Any process that modulates the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation." [GOC:BHF]	OMA
NV2t008332001.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t008332001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008332001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t008332001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t008332001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008332001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t008332001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008332001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t008332001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t008332001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t008332001.1	molecular_function	GO:0140682	FAD-dependent H3K4me/H3K4me3 demethylase activity	"Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction." [PMID:22473470]	OMA
NV2t008332002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008332002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008332002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t008332002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t008332003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008332003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008332003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t008332003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t008332004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008332004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008332004.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t008332004.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t008332005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008332005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008332005.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t008332005.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t008332006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008332006.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008332006.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t008332006.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t008333001.1	biological_process	GO:0090160	Golgi to lysosome transport	"The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t008333001.1	biological_process	GO:0090160	Golgi to lysosome transport	"The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t008333001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t008337001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008337001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008337001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008338001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008338001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t008338001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	InterPro
NV2t008339001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008339001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t008339001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t008342001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t008342001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t008342001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008343001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	InterPro
NV2t008343001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	PANTHER
NV2t008343002.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	InterPro
NV2t008343002.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	PANTHER
NV2t008343003.1	biological_process	GO:2000009	negative regulation of protein localization to cell surface	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]	PANTHER
NV2t008343003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008343004.1	biological_process	GO:2000009	negative regulation of protein localization to cell surface	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]	PANTHER
NV2t008343004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008343005.1	biological_process	GO:2000009	negative regulation of protein localization to cell surface	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]	PANTHER
NV2t008343005.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t008343005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008343006.1	biological_process	GO:2000009	negative regulation of protein localization to cell surface	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]	PANTHER
NV2t008343006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008344001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t008344001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t008344002.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t008346001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t008346001.1	molecular_function	GO:0015643	toxic substance binding	"Binding to a toxic substance, a poisonous substance that causes damage to biological systems." [GOC:bf, GOC:curators, GOC:jl, GOC:pr]	InterPro
NV2t008347001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t008347001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008347001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008347002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t008347002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008347002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008350001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t008350001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t008350001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008350001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t008351001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t008351001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t008351001.1	biological_process	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	OMA
NV2t008351001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t008351001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t008351001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t008351001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t008351001.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t008351001.1	cellular_component	GO:0031207	Sec62/Sec63 complex	"A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809]	PANTHER
NV2t008351001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t008351001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t008351001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t008351001.1	molecular_function	GO:0022884	macromolecule transmembrane transporter activity	"Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t008351001.1	molecular_function	GO:0140318	protein transporter activity	"Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]	OMA
NV2t008353001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t008353001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008354001.1	biological_process	GO:0007041	lysosomal transport	"The directed movement of substances into, out of or within a lysosome." [GOC:ai]	OMA
NV2t008354001.1	biological_process	GO:0007041	lysosomal transport	"The directed movement of substances into, out of or within a lysosome." [GOC:ai]	PANTHER
NV2t008354001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t008354001.1	biological_process	GO:0044794	positive regulation by host of viral process	"A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected." [GOC:jl]	OMA
NV2t008354001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t008354001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t008354001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t008354001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008354001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t008354001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t008354001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t008354001.1	cellular_component	GO:0030140	trans-Golgi network transport vesicle	"A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]	OMA
NV2t008354001.1	molecular_function	GO:0005520	insulin-like growth factor binding	"Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732]	OMA
NV2t008354001.1	molecular_function	GO:0005537	mannose binding	"Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [GOC:jl, ISBN:0192800981]	OMA
NV2t008354001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t008354001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t008354001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008354001.1	molecular_function	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	OMA
NV2t008354001.1	molecular_function	GO:1905394	retromer complex binding	"Binding to a retromer complex." [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27385586]	OMA
NV2t008355001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t008355002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t008356001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	OMA
NV2t008356001.1	biological_process	GO:0006550	isoleucine catabolic process	"The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	OMA
NV2t008356001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t008356001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t008356001.1	biological_process	GO:0009154	purine ribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008356001.1	biological_process	GO:0034031	ribonucleoside bisphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t008356001.1	biological_process	GO:0034034	purine nucleoside bisphosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t008356001.1	biological_process	GO:0044273	sulfur compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]	OMA
NV2t008356001.1	biological_process	GO:0046949	fatty-acyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732]	OMA
NV2t008356001.1	biological_process	GO:0046950	cellular ketone body metabolic process	"The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732]	OMA
NV2t008356001.1	biological_process	GO:1902224	ketone body metabolic process	"The chemical reactions and pathways involving ketone body." [GOC:pr, GOC:TermGenie]	OMA
NV2t008356001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008356001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t008356001.1	molecular_function	GO:0016408	C-acyltransferase activity	"Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]	OMA
NV2t008356001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t008356001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008356001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t008357001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008357001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008357001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008357001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008359001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008359001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008359001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008359001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008360001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t008360001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t008360001.1	biological_process	GO:0150007	clathrin-dependent synaptic vesicle endocytosis	"Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786]	PANTHER
NV2t008360001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008360001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008360001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008360001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t008360002.1	biological_process	GO:0150007	clathrin-dependent synaptic vesicle endocytosis	"Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786]	PANTHER
NV2t008360002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008360002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008360003.1	biological_process	GO:0150007	clathrin-dependent synaptic vesicle endocytosis	"Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786]	PANTHER
NV2t008360003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008360003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008360004.1	biological_process	GO:0150007	clathrin-dependent synaptic vesicle endocytosis	"Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786]	PANTHER
NV2t008360004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008360004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008361001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008361001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008361001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008361001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t008362001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t008363001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008363001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	InterPro
NV2t008364001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008364001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008364002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008364002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008364003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008364003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008364004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008364004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008367001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008369001.1	biological_process	GO:0140289	obsolete protein mono-ADP-ribosylation	"OBSOLETE. The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids." [PMID:25043379]	PANTHER
NV2t008370001.1	biological_process	GO:0140289	obsolete protein mono-ADP-ribosylation	"OBSOLETE. The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids." [PMID:25043379]	PANTHER
NV2t008370001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t008370002.1	biological_process	GO:0140289	obsolete protein mono-ADP-ribosylation	"OBSOLETE. The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids." [PMID:25043379]	PANTHER
NV2t008370003.1	biological_process	GO:0140289	obsolete protein mono-ADP-ribosylation	"OBSOLETE. The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids." [PMID:25043379]	PANTHER
NV2t008373001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t008373001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008373001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008373001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008374001.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	PANTHER
NV2t008374002.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	PANTHER
NV2t008374003.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	PANTHER
NV2t008374004.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	PANTHER
NV2t008375001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008375001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t008375001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t008375001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t008375001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t008375001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008375001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008375001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008375002.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t008375002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t008375002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008375002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008376001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008376001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008376001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008376002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008376002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008376002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008376002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008376002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008376002.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t008378001.1	biological_process	GO:0009914	hormone transport	"The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]	OMA
NV2t008378001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008378001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008378001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t008378001.1	molecular_function	GO:0015196	L-tryptophan transmembrane transporter activity	"Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t008378001.1	molecular_function	GO:0015291	secondary active transmembrane transporter activity	"Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]	OMA
NV2t008378001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008378001.1	molecular_function	GO:1901702	salt transmembrane transporter activity	"Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t008378002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008378002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008378002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008378003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008378003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008378003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008379001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008380001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008380001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008382001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t008382001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008382002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t008382002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008383001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t008383001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t008383001.1	biological_process	GO:0006221	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008383001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t008383001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	OMA
NV2t008383001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t008383001.1	biological_process	GO:0019856	pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	OMA
NV2t008383001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008383001.1	cellular_component	GO:0097268	cytoophidium	"A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human." [GOC:mag, PMID:20513629, PMID:21930098, Wikipedia:CTP_synthase#Cytoophidium]	OMA
NV2t008383001.1	cellular_component	GO:0097268	cytoophidium	"A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human." [GOC:mag, PMID:20513629, PMID:21930098, Wikipedia:CTP_synthase#Cytoophidium]	PANTHER
NV2t008383001.1	molecular_function	GO:0003883	CTP synthase activity	"Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate." [PMID:12354108, RHEA:26426]	OMA
NV2t008383001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008383002.1	biological_process	GO:0006221	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008383002.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t008383002.1	cellular_component	GO:0097268	cytoophidium	"A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human." [GOC:mag, PMID:20513629, PMID:21930098, Wikipedia:CTP_synthase#Cytoophidium]	PANTHER
NV2t008383003.1	biological_process	GO:0006221	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008383003.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t008383003.1	cellular_component	GO:0097268	cytoophidium	"A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human." [GOC:mag, PMID:20513629, PMID:21930098, Wikipedia:CTP_synthase#Cytoophidium]	PANTHER
NV2t008384001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t008384001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t008384001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t008384001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t008384001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t008384001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t008386001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t008386001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t008386001.1	biological_process	GO:0006306	obsolete DNA methylation	"OBSOLETE. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	OMA
NV2t008386001.1	biological_process	GO:0006346	DNA methylation-dependent heterochromatin formation	"Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah]	OMA
NV2t008386001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t008386001.1	biological_process	GO:0031508	pericentric heterochromatin formation	"The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA." [GOC:mah, PMID:14612388, PMID:20206496, PMID:22729156]	OMA
NV2t008386001.1	biological_process	GO:0046651	lymphocyte proliferation	"The expansion of a lymphocyte population by cell division." [GOC:ai]	PANTHER
NV2t008386001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t008386001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t008386001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t008386001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008386001.1	cellular_component	GO:0005721	pericentric heterochromatin	"Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3)." [PMID:12019236, PMID:20206496, PMID:21437270, PMID:22729156, PMID:9413993]	OMA
NV2t008386001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t008386001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008386001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008386001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t008386001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t008387001.1	biological_process	GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411]	InterPro
NV2t008387001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008390001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008390001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t008390001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t008390001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008390001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t008390001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t008390001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t008390001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t008390001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t008393001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008393002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008393003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008394001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t008394001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008394001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008394002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008394002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008395001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008395001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008396001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008396001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008396002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008396002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008397001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t008397001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t008407001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t008407001.1	biological_process	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	OMA
NV2t008407001.1	biological_process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	"Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah]	OMA
NV2t008407001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	InterPro
NV2t008407001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	PANTHER
NV2t008407001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008411001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008411001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t008417001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008417001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t008421001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008421001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008424001.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	OMA
NV2t008424001.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	PANTHER
NV2t008424001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t008424001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t008424001.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t008424002.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	PANTHER
NV2t008424002.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t008424003.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	PANTHER
NV2t008424003.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t008424004.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	PANTHER
NV2t008424004.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t008424005.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	PANTHER
NV2t008424005.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t008426001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t008426001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008426001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t008431001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t008431001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008431001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008431001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t008435001.1	biological_process	GO:0006559	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	OMA
NV2t008435001.1	biological_process	GO:0006570	tyrosine metabolic process	"The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]	InterPro
NV2t008435001.1	biological_process	GO:0006570	tyrosine metabolic process	"The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]	OMA
NV2t008435001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t008435001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008436001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008436002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008437001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	InterPro
NV2t008437001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t008437002.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	InterPro
NV2t008437003.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	InterPro
NV2t008438001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	PANTHER
NV2t008438001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008438002.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t008438002.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t008438002.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	PANTHER
NV2t008438002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008439001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t008439001.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	InterPro
NV2t008439001.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	OMA
NV2t008439001.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t008439001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008439002.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	InterPro
NV2t008439002.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t008439003.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	InterPro
NV2t008439003.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t008439004.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	InterPro
NV2t008439004.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t008439005.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	InterPro
NV2t008439005.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t008439006.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	InterPro
NV2t008439006.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t008441001.1	cellular_component	GO:0043020	NADPH oxidase complex	"A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]	PANTHER
NV2t008441001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008441002.1	cellular_component	GO:0043020	NADPH oxidase complex	"A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]	PANTHER
NV2t008441002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008441002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t008447001.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t008447001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t008451001.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t008451001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t008453001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t008453002.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t008454001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t008454001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t008454001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008454001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008455001.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	PANTHER
NV2t008455001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t008455002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t008455002.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	PANTHER
NV2t008455002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t008455002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t008455003.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	PANTHER
NV2t008455004.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	PANTHER
NV2t008455005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008455005.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	PANTHER
NV2t008455005.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t008455006.1	cellular_component	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	PANTHER
NV2t008455006.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t008456001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	OMA
NV2t008456001.1	biological_process	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	"The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t008456001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t008456001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t008456001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	InterPro
NV2t008456001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t008456001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t008456001.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t008456001.1	molecular_function	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t008457001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t008457001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008457001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t008458001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t008458001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t008458001.1	biological_process	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	OMA
NV2t008458001.1	biological_process	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t008458001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008458001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008458001.1	cellular_component	GO:0031588	nucleotide-activated protein kinase complex	"A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae)." [GOC:bhm, GOC:mah, GOC:vw]	PANTHER
NV2t008458001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t008458001.1	cellular_component	GO:1902911	protein kinase complex	"A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]	OMA
NV2t008458001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008458001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t008459001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t008459001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t008459001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t008459001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t008459001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t008459001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008459001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008459002.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t008459002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008459003.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t008459003.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t008459003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008460001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t008460001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t008460001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t008460001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t008460001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t008460001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008460001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008462001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t008463001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t008463002.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t008464001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008465001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008465001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	InterPro
NV2t008465001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t008465001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t008465001.1	biological_process	GO:0043966	obsolete histone H3 acetylation	"OBSOLETE. The modification of histone H3 by the addition of an acetyl group." [GOC:jl]	PANTHER
NV2t008465001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t008465001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t008465001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t008465001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t008468001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t008468001.1	biological_process	GO:0009069	serine family amino acid metabolic process	"The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t008468001.1	biological_process	GO:0036088	D-serine catabolic process	"The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:imk]	PANTHER
NV2t008468001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t008468001.1	molecular_function	GO:0016840	carbon-nitrogen lyase activity	"Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]	OMA
NV2t008469001.1	molecular_function	GO:0051864	histone H3K36 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16362057]	PANTHER
NV2t008470001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t008471001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t008471001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t008471001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t008472001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t008472001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t008472001.1	cellular_component	GO:0031080	nuclear pore outer ring	"A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t008472001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008473001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t008473001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t008473001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t008473001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t008473001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t008473002.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t008473002.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t008478001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008478001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t008478001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t008478001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t008478001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t008478001.1	cellular_component	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	OMA
NV2t008478001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008478001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t008478001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t008479001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t008479001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008479001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008479001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008481001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t008481001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008482001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t008482001.1	biological_process	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]	InterPro
NV2t008482001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t008482001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t008482001.1	cellular_component	GO:0043541	UDP-N-acetylglucosamine transferase complex	"A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis." [GOC:rn, PMID:19129246]	PANTHER
NV2t008482001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t008482001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t008482001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t008482001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t008483001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t008483001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t008483001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t008483001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t008483001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t008483001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t008483001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t008483001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t008483001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008483001.1	molecular_function	GO:0005104	fibroblast growth factor receptor binding	"Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb]	OMA
NV2t008483001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t008483001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t008483002.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t008484001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t008484001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t008484001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t008484001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t008484001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t008484001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t008484001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t008484001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t008484001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008484001.1	molecular_function	GO:0005104	fibroblast growth factor receptor binding	"Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb]	OMA
NV2t008484001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t008484001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t008485001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t008486001.1	biological_process	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation	"A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]	PANTHER
NV2t008486001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t008486003.1	biological_process	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation	"A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]	PANTHER
NV2t008486004.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t008487001.1	cellular_component	GO:0071565	nBAF complex	"A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth." [GOC:mah, GOC:ss, PMID:17640523]	PANTHER
NV2t008487001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008488001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008488001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t008488001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t008488001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t008488001.1	molecular_function	GO:0070402	NADPH binding	"Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t008489001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t008489002.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t008489003.1	biological_process	GO:0016556	mRNA modification	"The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t008489003.1	biological_process	GO:0031119	tRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]	OMA
NV2t008489003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008489003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t008489003.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t008489003.1	molecular_function	GO:0016866	intramolecular transferase activity	"Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t008489004.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t008490001.1	biological_process	GO:0019755	one-carbon compound transport	"The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t008490001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t008490001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t008490001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t008490001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t008490001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008490001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t008491001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t008491001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	OMA
NV2t008491001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008491001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008493001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t008493001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t008493001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t008493001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008493001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008493001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t008494001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008494001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t008494001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t008494001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t008494001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t008494001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t008494001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t008494002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008494002.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t008494003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008494003.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t008495002.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t008495002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008495005.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t008495006.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t008495006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008495009.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t008495009.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008498001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008498001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t008498002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008498002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t008498002.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t008498002.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t008498002.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t008498003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008498003.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t008498004.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008498004.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t008499003.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t008501001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t008503001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t008503001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008504001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t008504001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t008504001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t008504001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t008504001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t008505001.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t008505001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t008505001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t008505001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t008506001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t008506001.1	biological_process	GO:0150007	clathrin-dependent synaptic vesicle endocytosis	"Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786]	OMA
NV2t008506001.1	biological_process	GO:0150007	clathrin-dependent synaptic vesicle endocytosis	"Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786]	PANTHER
NV2t008506001.1	cellular_component	GO:0005905	clathrin-coated pit	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]	OMA
NV2t008506001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t008506001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008506001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008506001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008506001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t008508001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t008508001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008508001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008508001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008509001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t008509001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008509001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008509002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t008509002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008509002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008510001.1	biological_process	GO:0051013	microtubule severing	"The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends." [GOC:ai, PMID:27037673]	InterPro
NV2t008510001.1	biological_process	GO:0051013	microtubule severing	"The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends." [GOC:ai, PMID:27037673]	OMA
NV2t008510001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t008510001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008510001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t008510001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t008510001.1	cellular_component	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	OMA
NV2t008510001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008510001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t008510001.1	molecular_function	GO:0008568	microtubule severing ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [PMID:10910766]	OMA
NV2t008510001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008510001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t008510001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008510001.1	molecular_function	GO:0140603	obsolete ATP hydrolysis activity	"OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [GOC:curators]	PANTHER
NV2t008511001.1	biological_process	GO:0006650	glycerophospholipid metabolic process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t008511001.1	biological_process	GO:0009395	phospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t008511001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t008511001.1	biological_process	GO:0046503	glycerolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t008511001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008511001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t008511001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t008511001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008511001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	OMA
NV2t008511001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008511001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t008511001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	OMA
NV2t008511001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t008512001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t008512001.1	biological_process	GO:0021953	central nervous system neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t008512001.1	biological_process	GO:0045666	positive regulation of neuron differentiation	"Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]	OMA
NV2t008512001.1	biological_process	GO:0045666	positive regulation of neuron differentiation	"Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]	PANTHER
NV2t008512001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t008512001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t008512001.1	biological_process	GO:2000677	regulation of transcription regulatory region DNA binding	"Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol]	OMA
NV2t008512001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008512001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008512001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t008512001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t008513001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008513001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t008513001.1	biological_process	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t008513001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t008513001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t008513001.1	biological_process	GO:0050688	regulation of defense response to virus	"Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]	OMA
NV2t008513001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t008513001.1	biological_process	GO:0071586	CAAX-box protein processing	"The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]	InterPro
NV2t008513001.1	biological_process	GO:0071586	CAAX-box protein processing	"The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]	PANTHER
NV2t008513001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	OMA
NV2t008513001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t008513001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t008513001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t008513001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t008513001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t008513002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008513002.1	biological_process	GO:0071586	CAAX-box protein processing	"The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]	InterPro
NV2t008513002.1	biological_process	GO:0071586	CAAX-box protein processing	"The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]	PANTHER
NV2t008514001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t008514001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t008514001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t008514001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t008514001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008514001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008514001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t008515001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t008516001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t008517001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008517001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t008517001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008517001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008517001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008517002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008517003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008517004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008517004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008517004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008519001.1	biological_process	GO:2000643	positive regulation of early endosome to late endosome transport	"Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	PANTHER
NV2t008519001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t008519001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t008519002.1	biological_process	GO:2000643	positive regulation of early endosome to late endosome transport	"Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	PANTHER
NV2t008519002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t008519002.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t008519003.1	biological_process	GO:2000643	positive regulation of early endosome to late endosome transport	"Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	PANTHER
NV2t008519003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t008519003.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t008519004.1	biological_process	GO:2000643	positive regulation of early endosome to late endosome transport	"Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	PANTHER
NV2t008519004.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t008519004.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t008519005.1	biological_process	GO:2000643	positive regulation of early endosome to late endosome transport	"Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	PANTHER
NV2t008519005.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t008519005.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t008520001.1	biological_process	GO:0055001	muscle cell development	"The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]	PANTHER
NV2t008520001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008520002.1	biological_process	GO:0055001	muscle cell development	"The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]	PANTHER
NV2t008520002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008523001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t008523001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t008523001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t008523001.1	cellular_component	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	"A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838]	PANTHER
NV2t008523001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t008523001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t008523001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008523001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t008530001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t008530001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t008530001.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	InterPro
NV2t008531001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t008531001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t008531001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t008531001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t008531001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t008531001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008531001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t008531001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t008531001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t008531001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t008531001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t008531001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t008531001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t008531001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t008531001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	OMA
NV2t008531001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t008531001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t008532001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t008534001.1	biological_process	GO:0031054	pre-miRNA processing	"A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]	PANTHER
NV2t008534001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008534001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008535001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t008535001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t008535002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t008535002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t008538001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t008539001.1	biological_process	GO:0006525	arginine metabolic process	"The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]	OMA
NV2t008539001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t008539001.1	biological_process	GO:0009084	glutamine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t008539001.1	biological_process	GO:0043604	amide biosynthetic process	"The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]	OMA
NV2t008539001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t008539001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t008539001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008539001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t008539001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t008539001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t008539001.1	molecular_function	GO:0016743	carboxyl- or carbamoyltransferase activity	"Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008539001.1	molecular_function	GO:0016743	carboxyl- or carbamoyltransferase activity	"Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t008539002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t008539002.1	molecular_function	GO:0016743	carboxyl- or carbamoyltransferase activity	"Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008545001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008546001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	InterPro
NV2t008546001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	OMA
NV2t008546001.1	biological_process	GO:0080129	proteasome core complex assembly	"The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [PMID:12401807, PMID:17971041]	PANTHER
NV2t008546001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t008547001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t008547001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008547001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008552001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008552001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t008552001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008552001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008552002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008552002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008552002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t008552002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t008552002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008552002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008552002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008552003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008552003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t008552003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008552003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008553001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t008555001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t008555001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008555001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t008556001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t008556001.1	biological_process	GO:0007097	nuclear migration	"The directed movement of the nucleus to a specific location within a cell." [GOC:ai]	OMA
NV2t008556001.1	biological_process	GO:0008090	retrograde axonal transport	"The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]	OMA
NV2t008556001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t008556001.1	biological_process	GO:0047496	vesicle transport along microtubule	"The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl]	OMA
NV2t008556001.1	biological_process	GO:0051293	establishment of spindle localization	"The directed movement of the spindle to a specific location in the cell." [GOC:ai]	OMA
NV2t008556001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t008556001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t008556001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t008556001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t008556001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t008556001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008556001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008556001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008556001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t008556001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t008557001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t008557001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t008559001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008559002.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t008559002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008559002.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008559002.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t008559003.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008561001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t008561001.1	biological_process	GO:0032048	cardiolipin metabolic process	"The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah]	OMA
NV2t008561001.1	biological_process	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t008561001.1	biological_process	GO:2000304	positive regulation of ceramide biosynthetic process	"Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph]	OMA
NV2t008561001.1	biological_process	GO:2000304	positive regulation of ceramide biosynthetic process	"Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph]	PANTHER
NV2t008561001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008561001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t008561001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t008561001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008561001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t008562001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t008562001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008562002.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t008562002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t008562002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t008562002.1	biological_process	GO:0010001	glial cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]	OMA
NV2t008562002.1	biological_process	GO:0051482	obsolete positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	"OBSOLETE. Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol." [GOC:ai, GOC:signaling]	OMA
NV2t008562002.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t008562002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008562002.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t008562002.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t008562002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008562002.1	molecular_function	GO:0030551	cyclic nucleotide binding	"Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai]	OMA
NV2t008562002.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t008562002.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t008562003.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t008562003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008565001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008565001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t008565002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008565003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008565004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008566001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t008566001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t008566001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t008569001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t008569001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t008569001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t008569001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008569001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008569001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008571001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t008571001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008571002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t008571002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008571003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t008571003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008571004.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t008571004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008571005.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t008571005.1	biological_process	GO:0046456	icosanoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732]	OMA
NV2t008571005.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t008571005.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t008571005.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t008571005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008571005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008571005.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t008571005.1	molecular_function	GO:0004602	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]	OMA
NV2t008571005.1	molecular_function	GO:0016846	carbon-sulfur lyase activity	"Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]	OMA
NV2t008571005.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008571006.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t008571006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008575001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008575001.1	molecular_function	GO:0050262	ribosylnicotinamide kinase activity	"Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide." [EC:2.7.1.22, PMID:17914902, RHEA:14017]	PANTHER
NV2t008575002.1	molecular_function	GO:0050262	ribosylnicotinamide kinase activity	"Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide." [EC:2.7.1.22, PMID:17914902, RHEA:14017]	PANTHER
NV2t008575004.1	molecular_function	GO:0050262	ribosylnicotinamide kinase activity	"Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide." [EC:2.7.1.22, PMID:17914902, RHEA:14017]	PANTHER
NV2t008576001.1	biological_process	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	OMA
NV2t008576001.1	biological_process	GO:0048738	cardiac muscle tissue development	"The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]	OMA
NV2t008576001.1	biological_process	GO:0060048	cardiac muscle contraction	"Muscle contraction of cardiac muscle tissue." [GOC:dph]	OMA
NV2t008576001.1	biological_process	GO:0060415	muscle tissue morphogenesis	"The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph]	OMA
NV2t008576001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	OMA
NV2t008576001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t008576001.1	cellular_component	GO:0031672	A band	"The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131]	OMA
NV2t008576001.1	molecular_function	GO:0003785	actin monomer binding	"Binding to monomeric actin, also known as G-actin." [GOC:ai]	OMA
NV2t008576001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008576001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008577002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008579001.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	InterPro
NV2t008579001.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	OMA
NV2t008579001.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	PANTHER
NV2t008579001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008579001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008579001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008579001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t008579001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t008579002.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	InterPro
NV2t008579002.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	PANTHER
NV2t008579002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008580001.1	biological_process	GO:0006119	oxidative phosphorylation	"The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309]	OMA
NV2t008580001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008580001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	OMA
NV2t008580001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008580001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t008580001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	InterPro
NV2t008580001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	PANTHER
NV2t008582001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t008582001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t008583001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008583001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t008587001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t008587001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t008588001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t008588001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t008588001.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t008588001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t008588002.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t008588002.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t008590001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t008590001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008590001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t008590001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t008590001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t008591001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008593001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008594001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t008594001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t008594001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008597001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t008597001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t008599001.1	biological_process	GO:0016239	positive regulation of macroautophagy	"Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]	OMA
NV2t008599001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t008599001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t008599001.1	biological_process	GO:0071233	cellular response to L-leucine	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-leucine stimulus." [GOC:mah]	OMA
NV2t008599001.1	biological_process	GO:0098869	cellular oxidant detoxification	"Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide." [GOC:dos, GOC:vw]	OMA
NV2t008599001.1	biological_process	GO:1901031	regulation of response to reactive oxygen species	"Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]	InterPro
NV2t008599001.1	biological_process	GO:1901031	regulation of response to reactive oxygen species	"Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie]	OMA
NV2t008599001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t008599001.1	biological_process	GO:1990253	cellular response to leucine starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine." [PMID:19033384]	PANTHER
NV2t008599001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008599001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008599001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t008599001.1	molecular_function	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t008602001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008602001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008602001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008602001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008605001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t008605001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008605001.1	biological_process	GO:0097681	double-strand break repair via alternative nonhomologous end joining	"An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining]	PANTHER
NV2t008605001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008606001.1	biological_process	GO:0097681	double-strand break repair via alternative nonhomologous end joining	"An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining]	PANTHER
NV2t008606001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008607001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t008607001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t008607001.1	biological_process	GO:0006437	tyrosyl-tRNA aminoacylation	"The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t008607001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008607001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	InterPro
NV2t008607001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t008607001.1	molecular_function	GO:0004831	tyrosine-tRNA ligase activity	"Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+." [EC:6.1.1.1, RHEA:10220]	OMA
NV2t008607001.1	molecular_function	GO:0004831	tyrosine-tRNA ligase activity	"Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+." [EC:6.1.1.1, RHEA:10220]	PANTHER
NV2t008607001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008609001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t008612001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008613002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008613003.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t008613003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008614001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t008620001.1	biological_process	GO:0006269	DNA replication, synthesis of primer	"The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718]	OMA
NV2t008620001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t008620001.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t008620001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t008620001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	OMA
NV2t008620001.1	biological_process	GO:2000780	negative regulation of double-strand break repair	"Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t008620001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t008620001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t008621001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008621001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	InterPro
NV2t008621001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008622001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008622001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008624001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t008624001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008624001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008626001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008627001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	OMA
NV2t008627001.1	biological_process	GO:0006390	mitochondrial transcription	"The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl, PMID:23632312]	OMA
NV2t008627001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t008627001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t008627001.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	InterPro
NV2t008627001.1	molecular_function	GO:0016433	rRNA (adenine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators]	OMA
NV2t008627001.1	molecular_function	GO:0034246	mitochondrial transcription factor activity	"Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175]	PANTHER
NV2t008627001.1	molecular_function	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	OMA
NV2t008630001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t008636001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t008636001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t008636001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008636001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008636001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008636001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008641001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008642001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t008642001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008642001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008642001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t008644001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t008645001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t008648001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t008648001.1	biological_process	GO:0034227	tRNA thio-modification	"The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]	InterPro
NV2t008648001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t008648001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008648001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t008648001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t008648001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t008648001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t008648002.1	biological_process	GO:0034227	tRNA thio-modification	"The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]	InterPro
NV2t008648002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t008649001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t008649001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t008649001.1	biological_process	GO:0009411	response to UV	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]	OMA
NV2t008649001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t008649001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t008649001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t008649001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t008649001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008650001.1	biological_process	GO:0006597	spermine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [GOC:curators]	OMA
NV2t008650001.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008650001.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t008650001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008650001.1	molecular_function	GO:0004014	adenosylmethionine decarboxylase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2." [EC:4.1.1.50, RHEA:15981]	InterPro
NV2t008650001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t008650001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008650001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t008650002.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008650002.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t008650002.1	molecular_function	GO:0004014	adenosylmethionine decarboxylase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2." [EC:4.1.1.50, RHEA:15981]	InterPro
NV2t008650003.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008650003.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t008650004.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008650004.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t008650005.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t008650005.1	biological_process	GO:0008295	spermidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t008650005.1	molecular_function	GO:0004014	adenosylmethionine decarboxylase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + H+ = S-adenosylmethioninamine + CO2." [EC:4.1.1.50, RHEA:15981]	InterPro
NV2t008653001.1	molecular_function	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah]	PANTHER
NV2t008653002.1	molecular_function	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah]	PANTHER
NV2t008654001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t008654001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t008655001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008655001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008656001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t008657001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	InterPro
NV2t008657002.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	InterPro
NV2t008658001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t008658001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t008658001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t008658001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	InterPro
NV2t008658001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t008658001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008658001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t008658001.1	molecular_function	GO:0035173	histone kinase activity	"Catalysis of the transfer of a phosphate group to a histone." [GOC:bf]	OMA
NV2t008660001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t008660001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	OMA
NV2t008660001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t008661004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008661006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008662001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008662001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t008662001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t008662001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t008663001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t008663001.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t008663001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t008663001.1	biological_process	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	"Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476]	OMA
NV2t008663001.1	biological_process	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	"Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476]	PANTHER
NV2t008663001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t008663001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t008663001.1	cellular_component	GO:0031209	SCAR complex	"A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101]	OMA
NV2t008663001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t008663001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t008663001.1	molecular_function	GO:0034237	protein kinase A regulatory subunit binding	"Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah]	OMA
NV2t008663001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t008665001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t008665001.1	biological_process	GO:0006108	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t008665001.1	biological_process	GO:0006108	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	PANTHER
NV2t008665001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008665001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008665001.1	molecular_function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity	"Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+." [EC:1.1.1.40]	OMA
NV2t008665001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t008665001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t008665001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t008665001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t008665002.1	biological_process	GO:0006108	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	PANTHER
NV2t008665002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t008665002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t008665003.1	biological_process	GO:0006108	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	PANTHER
NV2t008665003.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t008665003.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t008666001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t008666001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t008666001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t008666001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	PANTHER
NV2t008666001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008666001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008666001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t008667001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t008667001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t008667001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t008667001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008667001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008667001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t008667001.1	molecular_function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease]	OMA
NV2t008667001.1	molecular_function	GO:0004519	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t008667001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t008667001.1	molecular_function	GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358]	OMA
NV2t008667001.1	molecular_function	GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358]	PANTHER
NV2t008668001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t008668001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008668001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008668001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t008668002.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t008668002.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t008668002.1	biological_process	GO:0031328	positive regulation of cellular biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t008668002.1	biological_process	GO:0034755	iron ion transmembrane transport	"A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah, PMID:11390404]	OMA
NV2t008668002.1	biological_process	GO:0051173	obsolete positive regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t008668002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t008668002.1	biological_process	GO:1901678	iron coordination entity transport	"The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie]	OMA
NV2t008668002.1	biological_process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	OMA
NV2t008668002.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t008668002.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t008668002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008668002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008668002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008668002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t008668002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t008668003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008669001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	InterPro
NV2t008669001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t008671001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t008673001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t008673001.1	biological_process	GO:0007007	inner mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t008673001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	OMA
NV2t008673001.1	biological_process	GO:0090151	establishment of protein localization to mitochondrial membrane	"The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t008673001.1	cellular_component	GO:0042719	mitochondrial intermembrane space protein transporter complex	"Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]	OMA
NV2t008674001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t008674001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t008674001.1	biological_process	GO:0016598	protein arginylation	"The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]	InterPro
NV2t008674001.1	biological_process	GO:0016598	protein arginylation	"The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]	PANTHER
NV2t008674001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t008674001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008674001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008674001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t008674002.1	biological_process	GO:0016598	protein arginylation	"The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]	InterPro
NV2t008674002.1	biological_process	GO:0016598	protein arginylation	"The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]	PANTHER
NV2t008674003.1	biological_process	GO:0016598	protein arginylation	"The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]	InterPro
NV2t008674003.1	biological_process	GO:0016598	protein arginylation	"The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]	PANTHER
NV2t008675001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t008676001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008676001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t008676001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t008676001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t008676001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t008676001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t008676001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008676002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t008676003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008676003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t008676004.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t008676004.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t008676004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008676005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t008676005.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t008676005.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t008676005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008676006.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t008676006.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t008676006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008679001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t008679001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t008679001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008681001.1	cellular_component	GO:0031422	RecQ family helicase-topoisomerase III complex	"A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139]	PANTHER
NV2t008681001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t008683001.1	cellular_component	GO:0031422	RecQ family helicase-topoisomerase III complex	"A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139]	PANTHER
NV2t008683001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t008686001.1	biological_process	GO:0000712	resolution of meiotic recombination intermediates	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]	OMA
NV2t008686001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t008686001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t008686001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t008686001.1	cellular_component	GO:0031422	RecQ family helicase-topoisomerase III complex	"A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139]	PANTHER
NV2t008686001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t008686001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t008686001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t008688002.1	cellular_component	GO:0031422	RecQ family helicase-topoisomerase III complex	"A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139]	PANTHER
NV2t008688003.1	cellular_component	GO:0031422	RecQ family helicase-topoisomerase III complex	"A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139]	PANTHER
NV2t008688004.1	cellular_component	GO:0031422	RecQ family helicase-topoisomerase III complex	"A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139]	PANTHER
NV2t008688005.1	cellular_component	GO:0031422	RecQ family helicase-topoisomerase III complex	"A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139]	PANTHER
NV2t008690001.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008692001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008692001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008692001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008692001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008692001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008693001.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008693002.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t008693002.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008693003.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t008693003.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008693004.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008693005.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008693006.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008693007.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t008693007.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008693007.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008693007.1	molecular_function	GO:0005337	nucleoside transmembrane transporter activity	"Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]	OMA
NV2t008693007.1	molecular_function	GO:0015370	solute:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai]	OMA
NV2t008693008.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t008693008.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008693009.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t008694001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t008694002.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t008695001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008695002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008695003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008695004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008695005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008695006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008695007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008695008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008696001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t008696002.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t008697001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t008699001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008699002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008699003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008699004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008699005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008699006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008699007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008701001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t008701002.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t008701003.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t008702001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t008702001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t008702001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t008702001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008702001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008702001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t008702002.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t008702002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008703001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008703001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t008703001.1	biological_process	GO:0031179	peptide modification	"The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah]	InterPro
NV2t008703001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008703001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t008707001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008707002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008710001.1	cellular_component	GO:0031519	PcG protein complex	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]	PANTHER
NV2t008712001.1	molecular_function	GO:0004784	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]	OMA
NV2t008712001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t008712001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t008712001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t008712002.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t008712002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t008713001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t008713002.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t008713002.1	biological_process	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	OMA
NV2t008713002.1	biological_process	GO:0019725	cellular homeostasis	"Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]	OMA
NV2t008713002.1	biological_process	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	OMA
NV2t008713002.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t008713002.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t008713002.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t008713002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008713002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008713002.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t008713002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008713002.1	molecular_function	GO:0004784	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]	OMA
NV2t008713002.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t008713002.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t008713002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008713002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t008714001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t008714001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008714001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t008714001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t008714001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t008714001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t008714001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t008714002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008715001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t008715001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008715001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008715001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t008715001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t008715001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t008715001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t008715001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t008715001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t008716001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t008716001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008716001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t008716001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t008716001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t008716001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t008716001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t008716001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t008717001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t008717001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t008717001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t008717001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t008717001.1	biological_process	GO:0010508	positive regulation of autophagy	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t008717001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t008717001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t008717001.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t008717001.1	biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]	OMA
NV2t008717001.1	biological_process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t008717001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	OMA
NV2t008717001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t008717001.1	biological_process	GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]	OMA
NV2t008717001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t008717001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t008717001.1	biological_process	GO:0048863	stem cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]	OMA
NV2t008717001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t008717001.1	biological_process	GO:0050727	regulation of inflammatory response	"Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]	OMA
NV2t008717001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t008717001.1	biological_process	GO:0071569	protein ufmylation	"Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]	InterPro
NV2t008717001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t008717001.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t008717001.1	biological_process	GO:1990592	protein K69-linked ufmylation	"A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498]	PANTHER
NV2t008717001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008717001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t008717001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t008717001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t008717001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t008717001.1	molecular_function	GO:0061659	ubiquitin-like protein ligase activity	"Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]	OMA
NV2t008718001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t008718001.1	cellular_component	GO:0070274	RES complex	"A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p." [PMID:15565172, PMID:18809678, PMID:19010333, PMID:19033360]	PANTHER
NV2t008718001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t008718001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t008719001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008719002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008719002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008719002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008719002.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t008720001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008722001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008722001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008722001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008723001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t008723001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t008723001.1	biological_process	GO:0006903	vesicle targeting	"The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]	OMA
NV2t008723001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t008723001.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t008723001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008723001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008723002.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t008723002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008723003.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t008723003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008724001.1	biological_process	GO:0031167	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	PANTHER
NV2t008724001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t008724001.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	InterPro
NV2t008726001.1	biological_process	GO:0007204	positive regulation of cytosolic calcium ion concentration	"Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai]	OMA
NV2t008726001.1	biological_process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	"A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, GOC:signaling, PMID:9131252]	OMA
NV2t008726001.1	biological_process	GO:0007600	sensory perception	"The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph]	OMA
NV2t008726001.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	OMA
NV2t008726001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008726001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t008726001.1	biological_process	GO:0097553	calcium ion transmembrane import into cytosol	"A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore." [GOC:vw]	OMA
NV2t008726001.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	PANTHER
NV2t008726001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008726001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008727001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008727001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t008727001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t008727002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008727002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t008727003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008727003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t008727004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008727004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t008728001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t008728001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t008729001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t008732001.1	biological_process	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]	OMA
NV2t008732001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t008732001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t008732001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t008732001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t008732001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008732001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t008732001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	PANTHER
NV2t008733001.1	biological_process	GO:0009443	pyridoxal 5'-phosphate salvage	"Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl]	InterPro
NV2t008733001.1	biological_process	GO:0042823	pyridoxal phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]	OMA
NV2t008733001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008733001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t008733001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t008736001.1	biological_process	GO:0051353	positive regulation of oxidoreductase activity	"Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]	OMA
NV2t008736001.1	biological_process	GO:0140647	P450-containing electron transport chain	"A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways." [PMID:16042601]	InterPro
NV2t008736001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008736001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t008736001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t008736001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t008737001.1	biological_process	GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	"The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]	InterPro
NV2t008737001.1	biological_process	GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	"The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]	PANTHER
NV2t008737001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008738001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008739001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008739001.1	biological_process	GO:0006687	glycosphingolipid metabolic process	"The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]	OMA
NV2t008739001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t008739001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t008739001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t008739001.1	biological_process	GO:1901658	glycosyl compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t008739001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008739001.1	molecular_function	GO:0015925	galactosidase activity	"Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai]	OMA
NV2t008742001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t008742001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t008743001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t008743001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t008743001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t008743001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008743001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008743001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t008743001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t008743001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t008743002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008743002.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t008744001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t008744001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t008744001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t008744001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t008744001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t008744001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t008746001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t008746001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t008746001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t008746001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t008746001.1	biological_process	GO:0045324	late endosome to vacuole transport	"The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]	PANTHER
NV2t008746001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t008746001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t008746001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t008746001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t008748001.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	PANTHER
NV2t008748001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008748002.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008748002.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t008748002.1	biological_process	GO:0040029	epigenetic regulation of gene expression	"A process that modulates the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine methylation of DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]	OMA
NV2t008748002.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	OMA
NV2t008748002.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	PANTHER
NV2t008748002.1	molecular_function	GO:0001222	transcription corepressor binding	"Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc]	OMA
NV2t008748002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008748002.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t008748002.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	OMA
NV2t008748002.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	OMA
NV2t008748002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008748003.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	PANTHER
NV2t008748004.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	PANTHER
NV2t008749001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	InterPro
NV2t008749001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	OMA
NV2t008752001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t008753001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t008753001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t008754001.1	biological_process	GO:0010824	regulation of centrosome duplication	"Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]	OMA
NV2t008754001.1	biological_process	GO:0051298	centrosome duplication	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]	OMA
NV2t008754001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t008754001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t008754001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008754001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t008755001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008755001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t008757001.1	biological_process	GO:0009154	purine ribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008757001.1	biological_process	GO:0009158	ribonucleoside monophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008757001.1	biological_process	GO:0009167	purine ribonucleoside monophosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008757001.1	biological_process	GO:0010035	response to inorganic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm]	OMA
NV2t008757001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008757001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t008757001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	OMA
NV2t008757001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t008757001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t008758001.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t008759001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t008759001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t008759001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t008759001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t008759001.1	biological_process	GO:0031144	proteasome localization	"Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t008759001.1	biological_process	GO:0042742	defense response to bacterium	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]	OMA
NV2t008759001.1	biological_process	GO:0045089	positive regulation of innate immune response	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]	OMA
NV2t008759001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t008759001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008759001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t008759001.1	biological_process	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	"A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation." [PMID:20080635, PMID:21211726]	OMA
NV2t008759001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t008759001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008759001.1	cellular_component	GO:0017053	transcription repressor complex	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]	OMA
NV2t008759001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t008759001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t008759001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t008759001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008761001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t008761001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008761001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008761001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t008763001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t008763001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t008763001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008763001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t008763001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008763001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008763001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t008766001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t008766001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008766001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008766001.1	molecular_function	GO:0008417	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t008766001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t008768001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t008775001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008775001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008775001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t008775001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t008776001.1	biological_process	GO:0009914	hormone transport	"The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]	OMA
NV2t008776001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008776001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008776001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008776001.1	molecular_function	GO:0008514	organic anion transmembrane transporter activity	"Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t008776001.1	molecular_function	GO:0015291	secondary active transmembrane transporter activity	"Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]	OMA
NV2t008777001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t008777001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008777002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t008777002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008777003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t008777003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008777004.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t008777004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008777005.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t008777005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008778001.1	biological_process	GO:0006850	mitochondrial pyruvate transmembrane transport	"The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558]	InterPro
NV2t008778001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t008778001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t008778001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t008778001.1	molecular_function	GO:0050833	pyruvate transmembrane transporter activity	"Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t008778001.1	molecular_function	GO:0050833	pyruvate transmembrane transporter activity	"Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t008778002.1	biological_process	GO:0006850	mitochondrial pyruvate transmembrane transport	"The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558]	InterPro
NV2t008778002.1	molecular_function	GO:0050833	pyruvate transmembrane transporter activity	"Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t008779001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t008779001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t008779002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t008779003.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t008781001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t008781001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t008782001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t008782001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t008783001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t008785001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008786001.1	biological_process	GO:0003352	regulation of cilium movement	"Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]	InterPro
NV2t008786001.1	biological_process	GO:0003352	regulation of cilium movement	"Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]	OMA
NV2t008786001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t008787001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	PANTHER
NV2t008788001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t008788001.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	OMA
NV2t008788001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t008788001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008788001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008788001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t008788001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t008790001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t008790001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t008790001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t008790001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	OMA
NV2t008790001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t008790001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008790001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t008790001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t008790001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t008790001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t008790001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t008791001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t008791001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t008791001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t008795001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t008795001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t008795001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t008795001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t008795001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t008795001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008795001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008796001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t008796001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t008801001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t008801001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008801001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008803001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008805001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t008805001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008805001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008805001.1	molecular_function	GO:0042813	Wnt receptor activity	"Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]	InterPro
NV2t008806001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008806001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008806001.1	molecular_function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	OMA
NV2t008806001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008806001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t008806001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008806001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008806002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008806002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008806002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008806003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008808001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t008808001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t008808001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t008808001.1	molecular_function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t008808001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008808001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008810001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t008810001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t008810001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t008810001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t008810001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008810001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008810001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t008811001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t008811002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t008811002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t008811003.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t008812001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t008814001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t008814002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t008814002.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t008814002.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t008814002.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t008814002.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t008814002.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t008814002.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t008814002.1	molecular_function	GO:0070181	small ribosomal subunit rRNA binding	"Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh]	PANTHER
NV2t008815001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008815001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t008816001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008816001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t008816001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t008816001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t008816002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008816002.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t008818001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t008818001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t008819001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t008820001.1	biological_process	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	OMA
NV2t008820001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t008820001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t008820001.1	biological_process	GO:0140962	multicellular organismal-level chemical homeostasis	"A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell." [GOC:curators]	OMA
NV2t008820001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t008820001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t008820001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t008820001.1	molecular_function	GO:0032794	GTPase activating protein binding	"Binding to a GTPase activating protein." [GOC:nln]	OMA
NV2t008820001.1	molecular_function	GO:0032794	GTPase activating protein binding	"Binding to a GTPase activating protein." [GOC:nln]	PANTHER
NV2t008821001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t008821001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008821001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008823001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t008823001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t008823001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t008823001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t008823001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008823001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008825001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t008825001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t008825001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t008825001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t008825001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008825001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008825001.1	molecular_function	GO:0140104	molecular carrier activity	"Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t008826006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008826006.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008826008.1	biological_process	GO:0055001	muscle cell development	"The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]	PANTHER
NV2t008826008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008826011.1	biological_process	GO:0055001	muscle cell development	"The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]	PANTHER
NV2t008826011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008827001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t008827001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t008828001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t008828001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t008828001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008828001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008829001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008829001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008829002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008829002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008833001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008834001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008836001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008837001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008840001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t008840001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008840001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008840001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008840001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t008840001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t008840001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t008841001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t008841001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	PANTHER
NV2t008841001.1	cellular_component	GO:0000940	outer kinetochore	"The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]	OMA
NV2t008842001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t008842001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t008842001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t008842001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t008846001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008846001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008850001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008853001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	PANTHER
NV2t008853001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008853002.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	PANTHER
NV2t008853002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008853003.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t008853003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008853003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t008853004.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t008853004.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008853004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t008853005.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t008853005.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008853005.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t008853006.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t008853006.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008853006.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t008853007.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t008853007.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t008853007.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t008854001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008860001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008863001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008867001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008867001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008867001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t008869001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008870003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008870004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t008872001.1	biological_process	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	"The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in mitosis." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]	InterPro
NV2t008872001.1	biological_process	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	"The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in mitosis." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]	PANTHER
NV2t008874001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008874001.1	molecular_function	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t008875001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t008875001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t008875001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t008875001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008875001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008875001.1	molecular_function	GO:0051920	peroxiredoxin activity	"Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]	InterPro
NV2t008875001.1	molecular_function	GO:0051920	peroxiredoxin activity	"Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]	OMA
NV2t008876001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t008876001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008877001.1	cellular_component	GO:0033186	CAF-1 complex	"A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276]	PANTHER
NV2t008877001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008877002.1	cellular_component	GO:0033186	CAF-1 complex	"A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276]	PANTHER
NV2t008877002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008877003.1	cellular_component	GO:0033186	CAF-1 complex	"A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276]	PANTHER
NV2t008877003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008878001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	PANTHER
NV2t008878001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008879001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008879001.1	biological_process	GO:0006757	obsolete ATP generation from ADP	"OBSOLETE. The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai]	OMA
NV2t008879001.1	biological_process	GO:0009151	purine deoxyribonucleotide metabolic process	"The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008879001.1	biological_process	GO:0009167	purine ribonucleoside monophosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t008879001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008879001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008879001.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	OMA
NV2t008879001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t008879001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008879001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008879001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t008879002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008879002.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t008880001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008880001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t008880002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008881001.1	biological_process	GO:0006850	mitochondrial pyruvate transmembrane transport	"The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558]	InterPro
NV2t008881001.1	biological_process	GO:1901475	pyruvate transmembrane transport	"The directed movement of pyruvate across a membrane." [GOC:TermGenie]	OMA
NV2t008881001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t008881001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t008882001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	PANTHER
NV2t008882001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008882002.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	PANTHER
NV2t008882002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008883001.1	biological_process	GO:0006850	mitochondrial pyruvate transmembrane transport	"The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558]	InterPro
NV2t008883002.1	biological_process	GO:0006850	mitochondrial pyruvate transmembrane transport	"The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558]	InterPro
NV2t008883002.1	biological_process	GO:1901475	pyruvate transmembrane transport	"The directed movement of pyruvate across a membrane." [GOC:TermGenie]	OMA
NV2t008883002.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t008883002.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t008886001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	InterPro
NV2t008886002.1	biological_process	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	"Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine." [GOC:mah, GOC:tb, PMID:17998288]	OMA
NV2t008886002.1	biological_process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t008886002.1	cellular_component	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	OMA
NV2t008886002.1	cellular_component	GO:0030532	small nuclear ribonucleoprotein complex	"A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t008886002.1	cellular_component	GO:0071254	cytoplasmic U snRNP body	"A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]	OMA
NV2t008886002.1	cellular_component	GO:0071254	cytoplasmic U snRNP body	"A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]	PANTHER
NV2t008886002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008886002.1	molecular_function	GO:0017069	snRNA binding	"Binding to a small nuclear RNA (snRNA)." [GOC:mah]	OMA
NV2t008888001.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	OMA
NV2t008888001.1	biological_process	GO:0032507	maintenance of protein location in cell	"Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]	OMA
NV2t008888001.1	biological_process	GO:0042989	sequestering of actin monomers	"The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators]	PANTHER
NV2t008888001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t008888001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t008888001.1	molecular_function	GO:0003785	actin monomer binding	"Binding to monomeric actin, also known as G-actin." [GOC:ai]	OMA
NV2t008889001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t008889002.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t008890001.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t008890001.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	InterPro
NV2t008890001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t008890001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t008894001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008894001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t008894001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008894001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008894002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008894002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008895001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008897001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008897002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t008897002.1	molecular_function	GO:0047961	glycine N-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN]	InterPro
NV2t008899001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t008899001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t008899001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t008899001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008899001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t008899001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t008899001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t008899001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t008899001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t008900001.1	cellular_component	GO:0030687	preribosome, large subunit precursor	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]	PANTHER
NV2t008900001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008901001.1	cellular_component	GO:0030687	preribosome, large subunit precursor	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]	PANTHER
NV2t008901001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t008903001.1	cellular_component	GO:0030687	preribosome, large subunit precursor	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]	PANTHER
NV2t008904001.1	cellular_component	GO:0030687	preribosome, large subunit precursor	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]	PANTHER
NV2t008907001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t008907001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008910001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008910002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008911001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008911001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008911001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008911001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008911002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008911002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008912001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008914001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008914001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t008914002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008914002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t008914003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008914004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008914004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t008922001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008922002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008929001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	InterPro
NV2t008929001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t008929001.1	biological_process	GO:0031509	subtelomeric heterochromatin formation	"The compaction of chromatin into heterochromatin at the subtelomeric region." [GOC:mah, PMID:10219245, PMID:26205977]	InterPro
NV2t008929001.1	biological_process	GO:0031509	subtelomeric heterochromatin formation	"The compaction of chromatin into heterochromatin at the subtelomeric region." [GOC:mah, PMID:10219245, PMID:26205977]	OMA
NV2t008929001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008929001.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	OMA
NV2t008929001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	InterPro
NV2t008929001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t008930001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t008930001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t008930001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008930001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t008930001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008932001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t008933001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t008933001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t008933001.1	biological_process	GO:0030048	actin filament-based movement	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]	OMA
NV2t008933001.1	biological_process	GO:0035315	hair cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf]	OMA
NV2t008933001.1	biological_process	GO:0048562	embryonic organ morphogenesis	"Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t008933001.1	biological_process	GO:0090596	sensory organ morphogenesis	"Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]	OMA
NV2t008933001.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	OMA
NV2t008933001.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t008933001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008933001.1	cellular_component	GO:0005902	microvillus	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]	OMA
NV2t008933001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t008933001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t008933001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t008933001.1	molecular_function	GO:0000146	microfilament motor activity	"A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]	OMA
NV2t008933001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008933001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t008933001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t008933001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t008934001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t008934002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t008935001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	InterPro
NV2t008935001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t008935001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t008935001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008936001.1	biological_process	GO:0031344	regulation of cell projection organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]	PANTHER
NV2t008937001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t008937001.1	biological_process	GO:0046620	regulation of organ growth	"Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]	PANTHER
NV2t008937001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008937001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008939001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008940001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008940002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t008941001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t008941001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	InterPro
NV2t008941001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t008942001.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t008942001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008942002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t008942002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008944001.1	molecular_function	GO:0042602	riboflavin reductase (NADPH) activity	"Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+." [RHEA:19377]	PANTHER
NV2t008945001.1	biological_process	GO:0036416	tRNA stabilization	"Prevention of degradation of tRNA molecules." [GOC:aa, GOC:bf, PMID:20459084]	OMA
NV2t008945001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008945001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008945001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008945001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t008945001.1	molecular_function	GO:0016427	tRNA (cytidine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [GOC:go-curators]	OMA
NV2t008946001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t008946001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	OMA
NV2t008946001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	PANTHER
NV2t008946001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t008946001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008947001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t008947001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t008947001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008947001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t008947001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t008947002.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t008947002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t008948001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008948001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008948001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008948001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008948001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t008948001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t008948001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008948001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008948001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t008949001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008949001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t008949001.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t008949001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008949001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t008949001.1	molecular_function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655]	OMA
NV2t008949001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t008949002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008949002.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t008949002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008949003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008949003.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t008949003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008949004.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008949004.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t008949004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008949005.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t008949005.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t008949005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008951001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t008951001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008954001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t008954001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t008954001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008954001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t008954001.1	molecular_function	GO:0015276	ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t008956001.1	cellular_component	GO:1904423	dehydrodolichyl diphosphate synthase complex	"A protein complex which is capable of dehydrodolichyl diphosphate synthase activity." [GO_REF:0000088, GOC:TermGenie, PMID:25066056]	PANTHER
NV2t008956001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t008957001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t008957001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t008959001.1	biological_process	GO:0000096	sulfur amino acid metabolic process	"The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]	OMA
NV2t008959001.1	biological_process	GO:0006545	glycine biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators]	OMA
NV2t008959001.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t008959001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t008959001.1	biological_process	GO:0009436	glyoxylate catabolic process	"The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]	OMA
NV2t008959001.1	biological_process	GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	"The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators]	PANTHER
NV2t008959001.1	biological_process	GO:0042219	cellular modified amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t008959001.1	biological_process	GO:0044273	sulfur compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]	OMA
NV2t008959001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t008959001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t008959001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t008959001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t008959001.1	molecular_function	GO:0008453	alanine-glyoxylate transaminase activity	"Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44]	OMA
NV2t008959001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t008959001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t008959001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t008959001.1	molecular_function	GO:0043621	obsolete protein self-association	"OBSOLETE. Binding to a domain within the same polypeptide." [GOC:jl]	OMA
NV2t008962001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t008962001.1	biological_process	GO:0030149	sphingolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t008962001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t008962001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t008962001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t008962001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t008966001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t008966001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t008966001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t008966001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t008966001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t008966001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t008966001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t008968001.1	biological_process	GO:0048172	regulation of short-term neuronal synaptic plasticity	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]	PANTHER
NV2t008968002.1	biological_process	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t008968002.1	biological_process	GO:0038203	TORC2 signaling	"A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]	OMA
NV2t008968002.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t008968002.1	biological_process	GO:0048172	regulation of short-term neuronal synaptic plasticity	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]	OMA
NV2t008968002.1	biological_process	GO:0048172	regulation of short-term neuronal synaptic plasticity	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]	PANTHER
NV2t008968002.1	biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]	OMA
NV2t008968002.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t008968002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t008968002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t008968002.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t008968002.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t008968002.1	cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]	OMA
NV2t008968002.1	cellular_component	GO:0042734	presynaptic membrane	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]	OMA
NV2t008968002.1	cellular_component	GO:0043204	perikaryon	"The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl]	OMA
NV2t008968002.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t008968002.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t008968003.1	biological_process	GO:0048172	regulation of short-term neuronal synaptic plasticity	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]	PANTHER
NV2t008974001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008974001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008974001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t008974001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t008974001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008976001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008976001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t008976001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t008976001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t008976001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008977001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008977001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t008977001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t008979001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t008979001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t008979001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t008979001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t008979001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008979001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t008983001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008986001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008987001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t008987001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008987001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t008987001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t008987001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t008987001.1	molecular_function	GO:0050104	L-gulonate 3-dehydrogenase activity	"Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH." [EC:1.1.1.45, RHEA:12889]	OMA
NV2t008987001.1	molecular_function	GO:0050104	L-gulonate 3-dehydrogenase activity	"Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH." [EC:1.1.1.45, RHEA:12889]	PANTHER
NV2t008987001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t008988001.1	biological_process	GO:1990168	protein K33-linked deubiquitination	"A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein." [PMID:23827681]	PANTHER
NV2t008988001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t008989001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t008989001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t008990001.1	biological_process	GO:0006091	generation of precursor metabolites and energy	"The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]	OMA
NV2t008990001.1	biological_process	GO:0006801	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl]	OMA
NV2t008990001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t008990001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t008990001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t008990001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t008990001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t008992001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t008996001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t008996001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t008996001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t008996001.1	molecular_function	GO:0004869	cysteine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]	InterPro
NV2t008996001.1	molecular_function	GO:0004869	cysteine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]	OMA
NV2t008997001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	InterPro
NV2t008997001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t008999001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t008999001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t008999001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t008999001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t009002001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t009002001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	InterPro
NV2t009002001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	OMA
NV2t009002001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t009002001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t009002001.1	biological_process	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t009002001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t009002001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009002001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t009002001.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t009002001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009002001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t009002001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t009003001.1	cellular_component	GO:0005850	eukaryotic translation initiation factor 2 complex	"Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940]	PANTHER
NV2t009003001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t009004001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009004001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t009009001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t009009001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t009009001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009010001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t009010001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009011001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t009011002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t009011002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t009011003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t009012001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009012001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t009013001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009013001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t009013001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009014001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t009014001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009014002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t009014002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t009014002.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t009014002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t009014002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t009014002.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t009014002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009015001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009015001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t009015001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009015002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009015002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t009015002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009015002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009015003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009015003.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t009015003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009015003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009015004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009015004.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t009015004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009015004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009015005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009015005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009015005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009015006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009015006.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009017001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009017001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t009017001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009017001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009017002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009017002.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t009017002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009017002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009020001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t009020001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t009020001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t009020001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t009020001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t009022001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	InterPro
NV2t009022001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	OMA
NV2t009022001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009025001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009025001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t009028001.1	biological_process	GO:0007214	gamma-aminobutyric acid signaling pathway	"The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell." [GOC:mah]	OMA
NV2t009028001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009028001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	OMA
NV2t009028001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t009028001.1	molecular_function	GO:0004965	G protein-coupled GABA receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]	OMA
NV2t009029001.1	biological_process	GO:0006895	Golgi to endosome transport	"The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832]	InterPro
NV2t009032001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009032001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t009032001.1	biological_process	GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle	"Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t009032001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t009032001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009032001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009033001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009033002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009033003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009035001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	InterPro
NV2t009035001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	OMA
NV2t009035001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t009035001.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	InterPro
NV2t009035001.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	OMA
NV2t009035001.1	biological_process	GO:0046084	adenine biosynthetic process	"The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]	PANTHER
NV2t009035001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009035001.1	molecular_function	GO:0004637	phosphoribosylamine-glycine ligase activity	"Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate." [EC:6.3.4.13, RHEA:17453]	OMA
NV2t009035001.1	molecular_function	GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	"Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate." [EC:6.3.3.1, RHEA:23032]	OMA
NV2t009035001.1	molecular_function	GO:0004644	phosphoribosylglycinamide formyltransferase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2]	OMA
NV2t009035001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009035001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009035001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009035001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t009035002.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	InterPro
NV2t009035002.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t009035002.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	InterPro
NV2t009035002.1	biological_process	GO:0046084	adenine biosynthetic process	"The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]	PANTHER
NV2t009035002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009035002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009035003.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	InterPro
NV2t009035003.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t009035003.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	InterPro
NV2t009035003.1	biological_process	GO:0046084	adenine biosynthetic process	"The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]	PANTHER
NV2t009035003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009035003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009037001.1	biological_process	GO:0006801	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl]	OMA
NV2t009037001.1	biological_process	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	OMA
NV2t009037001.1	cellular_component	GO:0043020	NADPH oxidase complex	"A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]	PANTHER
NV2t009037001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t009037001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t009037001.1	molecular_function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	"Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195]	OMA
NV2t009037001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t009038001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009038001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t009038001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t009038001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t009038001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009038001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009039001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t009039001.1	biological_process	GO:0034499	late endosome to Golgi transport	"The directed movement of substances from late endosomes to the Golgi." [GOC:rb]	PANTHER
NV2t009039001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t009039001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t009039001.1	biological_process	GO:0051223	regulation of protein transport	"Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t009039001.1	cellular_component	GO:0030904	retromer complex	"A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157]	OMA
NV2t009039001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t009039001.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	OMA
NV2t009039001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t009041001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t009041001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t009041001.1	biological_process	GO:0048599	oocyte development	"The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]	OMA
NV2t009041001.1	biological_process	GO:0048599	oocyte development	"The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]	PANTHER
NV2t009041001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009041001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009041001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009041001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t009041001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t009042001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t009042001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t009042001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009042001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009042001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t009042001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t009045001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t009045001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t009045001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t009045001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t009045001.1	molecular_function	GO:0004879	nuclear receptor activity	"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]	OMA
NV2t009045001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009045001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009045001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t009047001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	InterPro
NV2t009047001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t009047001.1	cellular_component	GO:0000123	histone acetyltransferase complex	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]	OMA
NV2t009047001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	PANTHER
NV2t009047002.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	InterPro
NV2t009047002.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	PANTHER
NV2t009050001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t009050001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009050001.1	cellular_component	GO:0000974	Prp19 complex	"A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]	OMA
NV2t009050001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t009050001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t009050001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t009050001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t009051001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t009051001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t009051001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t009051001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t009052001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t009052001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t009052001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t009052001.1	biological_process	GO:0006312	mitotic recombination	"The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles." [GOC:elh]	OMA
NV2t009052001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t009052001.1	biological_process	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	OMA
NV2t009052001.1	biological_process	GO:0016444	somatic cell DNA recombination	"Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]	OMA
NV2t009052001.1	biological_process	GO:0043570	maintenance of DNA repeat elements	"Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl]	OMA
NV2t009052001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t009052001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t009052001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009052001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009052001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t009052001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t009052001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t009052001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t009052001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t009053001.1	biological_process	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	InterPro
NV2t009053001.1	biological_process	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	OMA
NV2t009053001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t009053001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t009055001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t009055001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009055002.1	biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t009055002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009055002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009055003.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	InterPro
NV2t009055003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009056001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009056002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009056003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009057001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t009057001.1	cellular_component	GO:0005689	U12-type spliceosomal complex	"Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]	InterPro
NV2t009057001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t009057001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t009057001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009057001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009057001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t009057001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009057001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009057002.1	cellular_component	GO:0005689	U12-type spliceosomal complex	"Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]	InterPro
NV2t009057002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009057002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009057002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009060001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009060001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t009061001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	InterPro
NV2t009061001.1	biological_process	GO:0006607	NLS-bearing protein import into nucleus	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai]	OMA
NV2t009061001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t009061001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009061001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009061001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009061001.1	molecular_function	GO:0008139	nuclear localization sequence binding	"Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai]	OMA
NV2t009061001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	InterPro
NV2t009061001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t009061001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t009062001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t009062001.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	OMA
NV2t009062001.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	PANTHER
NV2t009062001.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	OMA
NV2t009062001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t009062001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009062001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t009062002.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	PANTHER
NV2t009062003.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	PANTHER
NV2t009062004.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	PANTHER
NV2t009063001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t009063001.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	OMA
NV2t009063001.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	PANTHER
NV2t009063001.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	OMA
NV2t009063001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t009063001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009064001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t009066001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t009066001.1	molecular_function	GO:0070139	SUMO-specific endopeptidase activity	"Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah]	PANTHER
NV2t009067001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t009067001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t009067001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009067001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009073001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009074001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t009074001.1	cellular_component	GO:0000974	Prp19 complex	"A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]	OMA
NV2t009074001.1	cellular_component	GO:0071014	post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]	PANTHER
NV2t009074001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t009074001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t009074001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t009076001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t009076001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t009076001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t009076001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t009076001.1	molecular_function	GO:0016408	C-acyltransferase activity	"Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]	OMA
NV2t009076001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009076001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t009079001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t009079001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009079002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t009079002.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t009079002.1	biological_process	GO:0019217	regulation of fatty acid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]	OMA
NV2t009079002.1	biological_process	GO:0031327	negative regulation of cellular biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t009079002.1	biological_process	GO:0051055	negative regulation of lipid biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	OMA
NV2t009079002.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t009079002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009079002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t009079002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t009079002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009079002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009082001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	InterPro
NV2t009082001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t009083001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t009085001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009085001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009085001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t009086001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t009086001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t009086001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t009086001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009086001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009086001.1	molecular_function	GO:0035241	protein-arginine omega-N monomethyltransferase activity	"Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine." [EC:2.1.1.321, PMID:14705965, RESID:AA0069]	OMA
NV2t009086001.1	molecular_function	GO:0035241	protein-arginine omega-N monomethyltransferase activity	"Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine." [EC:2.1.1.321, PMID:14705965, RESID:AA0069]	PANTHER
NV2t009086001.1	molecular_function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069]	OMA
NV2t009087001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t009087001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t009087001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t009087001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	InterPro
NV2t009087001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t009087001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t009087001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t009087001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t009088001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t009088001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t009088002.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t009088002.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t009088002.1	biological_process	GO:0034759	regulation of iron ion transmembrane transport	"Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t009088002.1	biological_process	GO:0051349	positive regulation of lyase activity	"Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]	OMA
NV2t009088002.1	biological_process	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	OMA
NV2t009088002.1	biological_process	GO:1901857	positive regulation of cellular respiration	"Any process that activates or increases the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719]	OMA
NV2t009088002.1	biological_process	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone	"Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063]	OMA
NV2t009088002.1	biological_process	GO:1904063	negative regulation of cation transmembrane transport	"Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]	OMA
NV2t009088002.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t009088002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009088002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t009088002.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t009088002.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t009088002.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t009088002.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t009088002.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t009090001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t009090001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t009090001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t009090002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t009090003.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t009090004.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t009092001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009092001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009092002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009095001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t009095001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009095001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t009095001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t009095001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t009095001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t009095001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t009096001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t009096001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009096001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t009096001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t009096001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t009096001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t009096001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t009096002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t009096002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009096002.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t009096002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t009097001.1	biological_process	GO:0010466	negative regulation of peptidase activity	"Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t009097001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t009097001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009097001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009097001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t009097001.1	molecular_function	GO:0002020	protease binding	"Binding to a protease or a peptidase." [GOC:hjd]	OMA
NV2t009097001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t009097001.1	molecular_function	GO:0004869	cysteine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]	InterPro
NV2t009097001.1	molecular_function	GO:0004869	cysteine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]	OMA
NV2t009107001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009107001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t009107001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t009107001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009110001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t009112002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009112002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009112003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009112003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009112004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009112004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009114001.1	biological_process	GO:0006560	proline metabolic process	"The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t009114001.1	biological_process	GO:0006561	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	InterPro
NV2t009114001.1	biological_process	GO:0009084	glutamine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t009114001.1	biological_process	GO:0055129	L-proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd]	PANTHER
NV2t009114001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t009115001.1	cellular_component	GO:0005575	cellular_component	"A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt]	OMA
NV2t009115001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t009115001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009116001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t009116001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	PANTHER
NV2t009118001.1	cellular_component	GO:0030686	90S preribosome	"A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]	PANTHER
NV2t009119001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t009119001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	OMA
NV2t009119001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t009119001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009119001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009119001.1	molecular_function	GO:0001640	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	"Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph]	OMA
NV2t009120001.1	biological_process	GO:0045786	negative regulation of cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t009121001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009121001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t009121001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t009121001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t009121001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t009121001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	PANTHER
NV2t009121002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009121002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t009121002.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	PANTHER
NV2t009123001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009123002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009124001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t009124001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t009124001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t009124001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t009124001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009124001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t009124001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t009124001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009124001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009124002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t009124002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t009124002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009127001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t009127001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t009127001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t009127001.1	cellular_component	GO:0031466	Cul5-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t009127001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t009127001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t009127001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t009127001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009127002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t009127002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009128001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t009128001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t009128001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009128001.1	cellular_component	GO:0071008	U2-type post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]	InterPro
NV2t009128001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t009128002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t009128002.1	cellular_component	GO:0071008	U2-type post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]	InterPro
NV2t009128003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t009128003.1	cellular_component	GO:0071008	U2-type post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]	InterPro
NV2t009129001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t009129001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009129001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009131001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t009131001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009131001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t009131001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t009131001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009131001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009131001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t009133001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009133001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t009133001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t009133001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t009134001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t009134001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t009134001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	PANTHER
NV2t009136001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t009137001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009137001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009137001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t009137001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t009137001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t009139001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009139001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t009140001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t009140001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t009141001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t009141001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t009141001.1	biological_process	GO:0032781	positive regulation of ATP-dependent activity	"Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah]	OMA
NV2t009141001.1	biological_process	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t009141001.1	biological_process	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t009141001.1	biological_process	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t009141001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t009141001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009141001.1	cellular_component	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t009141001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t009141001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t009141001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t009141001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t009141001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t009141001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t009141001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t009141001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t009143001.1	biological_process	GO:0009636	response to toxic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr]	OMA
NV2t009143001.1	biological_process	GO:0019439	obsolete aromatic compound catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t009143001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t009143001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009143001.1	molecular_function	GO:0004064	arylesterase activity	"Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]	InterPro
NV2t009143001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t009143001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t009145001.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	PANTHER
NV2t009145001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009145002.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	PANTHER
NV2t009145002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009145003.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	PANTHER
NV2t009145003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009146001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t009146001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t009146001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t009146001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009146001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t009146001.1	cellular_component	GO:0016272	prefoldin complex	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]	InterPro
NV2t009146001.1	cellular_component	GO:0016272	prefoldin complex	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]	OMA
NV2t009146001.1	cellular_component	GO:0016272	prefoldin complex	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]	PANTHER
NV2t009146001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t009147001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t009148001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009148002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009148003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009149001.1	biological_process	GO:0007584	response to nutrient	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators]	OMA
NV2t009149001.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	OMA
NV2t009149001.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	PANTHER
NV2t009149001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t009149001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t009149001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t009149001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009149001.1	molecular_function	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t009149002.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	PANTHER
NV2t009149003.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	PANTHER
NV2t009149004.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	PANTHER
NV2t009151001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t009151001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t009152001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009155001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009158001.1	biological_process	GO:2001294	malonyl-CoA catabolic process	"The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A." [GOC:yaf]	PANTHER
NV2t009158001.1	molecular_function	GO:0050080	malonyl-CoA decarboxylase activity	"Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN]	InterPro
NV2t009160001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t009161001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t009162001.1	biological_process	GO:0039694	viral RNA genome replication	"The replication of a viral RNA genome." [GOC:bf, GOC:jl]	InterPro
NV2t009162001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009162001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009166001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009166001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t009166001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t009166002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009166003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009172001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t009172001.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	OMA
NV2t009172001.1	biological_process	GO:0051452	intracellular pH reduction	"Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]	OMA
NV2t009172001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	OMA
NV2t009172001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t009172001.1	cellular_component	GO:0045335	phagocytic vesicle	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t009172001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t009172001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009172001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t009172001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t009174001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t009174001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009175001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t009175001.1	biological_process	GO:0007029	endoplasmic reticulum organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t009175001.1	biological_process	GO:0007029	endoplasmic reticulum organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t009175001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t009175001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t009175001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t009175001.1	biological_process	GO:0019221	cytokine-mediated signaling pathway	"The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]	OMA
NV2t009175001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t009175001.1	biological_process	GO:0050832	defense response to fungus	"Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t009175001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t009176001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t009176001.1	biological_process	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	OMA
NV2t009176001.1	biological_process	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	PANTHER
NV2t009177001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t009177001.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	PANTHER
NV2t009177001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	OMA
NV2t009177001.1	biological_process	GO:0022406	membrane docking	"The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684]	OMA
NV2t009177001.1	biological_process	GO:0044091	membrane biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl]	OMA
NV2t009177001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t009177001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t009177001.1	molecular_function	GO:0008022	obsolete protein C-terminus binding	"OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t009177002.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	PANTHER
NV2t009183001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009185001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t009186001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009186001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t009186001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t009186001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t009187001.1	molecular_function	GO:1990050	phosphatidic acid transfer activity	"Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]	PANTHER
NV2t009188001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	PANTHER
NV2t009188002.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	PANTHER
NV2t009188002.1	biological_process	GO:0048311	mitochondrion distribution	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]	OMA
NV2t009188002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009188003.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	PANTHER
NV2t009189001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t009189001.1	molecular_function	GO:0005539	glycosaminoglycan binding	"Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t009194001.1	molecular_function	GO:0032934	sterol binding	"Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah]	InterPro
NV2t009195001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t009195001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009195001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t009195001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t009195001.1	molecular_function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease]	OMA
NV2t009195001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t009195001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009195001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009200001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009200002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009200003.1	molecular_function	GO:0004035	alkaline phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]	OMA
NV2t009200003.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009203001.1	biological_process	GO:0007584	response to nutrient	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators]	OMA
NV2t009203001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t009203001.1	biological_process	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t009203001.1	biological_process	GO:0014070	response to organic cyclic compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:ef]	OMA
NV2t009203001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t009203001.1	biological_process	GO:0033993	response to lipid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]	OMA
NV2t009203001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t009203001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t009203001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t009203001.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	OMA
NV2t009203001.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t009203001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t009203001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009203001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t009203001.1	molecular_function	GO:0004035	alkaline phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]	OMA
NV2t009203001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009203001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t009203001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009203001.1	molecular_function	GO:0016825	hydrolase activity, acting on acid phosphorus-nitrogen bonds	"Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl]	OMA
NV2t009203002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009206001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t009209001.1	biological_process	GO:0048268	clathrin coat assembly	"The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549]	InterPro
NV2t009209001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t009209001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	OMA
NV2t009209001.1	cellular_component	GO:0030136	clathrin-coated vesicle	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]	OMA
NV2t009209001.1	cellular_component	GO:0098894	extrinsic component of presynaptic endocytic zone membrane	"The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf]	PANTHER
NV2t009209001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t009209001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t009209001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t009213001.1	cellular_component	GO:0032045	guanyl-nucleotide exchange factor complex	"A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah]	PANTHER
NV2t009213001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t009214001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	InterPro
NV2t009217001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t009217001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t009217001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009217001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009218001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t009218001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t009218001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009222001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t009223001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009223001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t009223001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t009223001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	PANTHER
NV2t009223001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009223001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009225001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t009225001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	OMA
NV2t009225001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	PANTHER
NV2t009225001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009225001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t009228001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t009230001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t009234001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009238001.1	biological_process	GO:0050708	regulation of protein secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	PANTHER
NV2t009238001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009238002.1	biological_process	GO:0050708	regulation of protein secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	PANTHER
NV2t009238002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009238003.1	biological_process	GO:0050708	regulation of protein secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	PANTHER
NV2t009238003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009239001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t009239001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009239001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009239001.1	cellular_component	GO:0035371	microtubule plus-end	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]	OMA
NV2t009239001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	OMA
NV2t009239001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t009239003.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t009239004.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t009240001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009240001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009240001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t009240001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009240002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009240002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009241001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t009243001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009246001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t009246002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t009246002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t009246002.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t009246002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t009246002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t009246002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t009247001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t009247001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t009247001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t009248001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	PANTHER
NV2t009248001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009248001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t009248001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t009248001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009248001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009250001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009250002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009250003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009252001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	InterPro
NV2t009257001.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	PANTHER
NV2t009258001.1	cellular_component	GO:0048786	presynaptic active zone	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]	PANTHER
NV2t009258002.1	cellular_component	GO:0048786	presynaptic active zone	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]	PANTHER
NV2t009258003.1	cellular_component	GO:0048786	presynaptic active zone	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]	PANTHER
NV2t009259001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t009259001.1	molecular_function	GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	"Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:23190198, PMID:9083048]	InterPro
NV2t009259001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t009259003.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t009259003.1	molecular_function	GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	"Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:23190198, PMID:9083048]	InterPro
NV2t009260001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t009260001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t009260001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t009260001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t009260001.1	biological_process	GO:0010634	positive regulation of epithelial cell migration	"Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t009260001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t009260001.1	biological_process	GO:0032386	regulation of intracellular transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t009260001.1	biological_process	GO:0046165	alcohol biosynthetic process	"The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]	OMA
NV2t009260001.1	biological_process	GO:0051353	positive regulation of oxidoreductase activity	"Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]	OMA
NV2t009260001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	OMA
NV2t009260001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t009260001.1	cellular_component	GO:1904423	dehydrodolichyl diphosphate synthase complex	"A protein complex which is capable of dehydrodolichyl diphosphate synthase activity." [GO_REF:0000088, GOC:TermGenie, PMID:25066056]	PANTHER
NV2t009260001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t009260001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t009260001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009260002.1	cellular_component	GO:1904423	dehydrodolichyl diphosphate synthase complex	"A protein complex which is capable of dehydrodolichyl diphosphate synthase activity." [GO_REF:0000088, GOC:TermGenie, PMID:25066056]	PANTHER
NV2t009260002.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009260003.1	cellular_component	GO:1904423	dehydrodolichyl diphosphate synthase complex	"A protein complex which is capable of dehydrodolichyl diphosphate synthase activity." [GO_REF:0000088, GOC:TermGenie, PMID:25066056]	PANTHER
NV2t009260003.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009261001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t009261002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t009262001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t009264001.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	PANTHER
NV2t009264001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	OMA
NV2t009267001.1	molecular_function	GO:0016768	spermine synthase activity	"Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22]	PANTHER
NV2t009267002.1	molecular_function	GO:0016768	spermine synthase activity	"Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22]	PANTHER
NV2t009279001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t009279001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t009279001.1	molecular_function	GO:0016411	acylglycerol O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]	OMA
NV2t009279001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009279001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t009279001.1	molecular_function	GO:0042171	lysophosphatidic acid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]	OMA
NV2t009280001.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t009280001.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t009280001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t009280001.1	molecular_function	GO:0005337	nucleoside transmembrane transporter activity	"Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]	OMA
NV2t009280002.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t009280002.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t009282001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009283001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t009283001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009283001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t009283001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t009287001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t009287002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t009287003.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t009287004.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t009287005.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t009296001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009296001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t009302001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	OMA
NV2t009302001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t009302001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009302001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009303001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009303003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303009.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303010.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303011.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009303012.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009305001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t009305001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009307001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307011.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307012.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307013.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307014.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307015.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307016.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307018.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307020.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307021.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307022.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009307023.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009308001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009310001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t009310001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t009310001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t009310001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	InterPro
NV2t009310001.1	cellular_component	GO:0005801	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	OMA
NV2t009310001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009310001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t009310001.1	cellular_component	GO:1990071	TRAPPII protein complex	"A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]	OMA
NV2t009310001.1	cellular_component	GO:1990072	TRAPPIII protein complex	"A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257]	OMA
NV2t009310001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t009310001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009311001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t009311001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009311001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t009311001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t009311001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t009311001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t009311001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t009311001.1	molecular_function	GO:0060590	ATPase regulator activity	"Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]	OMA
NV2t009312001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	InterPro
NV2t009312001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t009312001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t009313001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t009313001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t009313001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009313001.1	molecular_function	GO:0000987	cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018]	OMA
NV2t009313001.1	molecular_function	GO:0106140	P-TEFb complex binding	"Binding to a P-TEFb complex." [GOC:pga, PMID:18391197]	PANTHER
NV2t009314001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009314002.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t009314002.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t009314002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009314002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009315001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t009315002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	InterPro
NV2t009315002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009315002.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	InterPro
NV2t009315002.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t009315003.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	InterPro
NV2t009315003.1	biological_process	GO:0006607	NLS-bearing protein import into nucleus	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai]	OMA
NV2t009315003.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t009315003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009315003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009315003.1	molecular_function	GO:0008139	nuclear localization sequence binding	"Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai]	OMA
NV2t009315003.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	InterPro
NV2t009315003.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t009315003.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t009316001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t009316001.1	biological_process	GO:0006858	extracellular transport	"The transport of substances that occurs outside cells." [GOC:go_curators]	OMA
NV2t009316001.1	biological_process	GO:0007286	spermatid development	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]	OMA
NV2t009316001.1	biological_process	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t009316001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t009316001.1	biological_process	GO:0044458	motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]	OMA
NV2t009316001.1	biological_process	GO:0098840	protein transport along microtubule	"The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607]	OMA
NV2t009316001.1	cellular_component	GO:0001669	acrosomal vesicle	"A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]	OMA
NV2t009316001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t009316001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t009316001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t009316001.1	cellular_component	GO:1990716	axonemal central apparatus	"Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]	PANTHER
NV2t009317001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009317001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t009317001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t009317002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009317002.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t009321001.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t009321001.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	OMA
NV2t009321001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t009321001.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t009321001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009321001.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t009321001.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	OMA
NV2t009321001.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	PANTHER
NV2t009324001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t009324001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009324002.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t009324002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009324003.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t009324003.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009324004.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t009324004.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009324005.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t009324005.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009324006.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t009324006.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t009327001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009327001.1	biological_process	GO:0010754	negative regulation of cGMP-mediated signaling	"Any process that decreases the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t009327001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009327001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t009327002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009327002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t009327002.1	biological_process	GO:0010754	negative regulation of cGMP-mediated signaling	"Any process that decreases the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t009327002.1	molecular_function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate." [RHEA:14653]	OMA
NV2t009327002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009327002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t009327003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009327003.1	biological_process	GO:0010754	negative regulation of cGMP-mediated signaling	"Any process that decreases the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t009327003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009327003.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t009327004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009327004.1	biological_process	GO:0010754	negative regulation of cGMP-mediated signaling	"Any process that decreases the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t009327004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009327004.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t009327005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009327005.1	biological_process	GO:0010754	negative regulation of cGMP-mediated signaling	"Any process that decreases the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t009327005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009327005.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t009330001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009330002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009331001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t009331001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009331002.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t009331002.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	OMA
NV2t009331002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t009331002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t009331002.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t009331002.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t009331002.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	OMA
NV2t009331002.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t009331002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009331002.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	OMA
NV2t009332001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009332001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t009332001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	OMA
NV2t009332001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t009332001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t009332001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t009332001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009332001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t009332001.1	molecular_function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]	OMA
NV2t009332001.1	molecular_function	GO:0052745	inositol phosphate phosphatase activity	"Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]	InterPro
NV2t009332001.1	molecular_function	GO:0052745	inositol phosphate phosphatase activity	"Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]	OMA
NV2t009336001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009336001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t009336001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009338001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009338001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t009339001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t009339001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t009339001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009339001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009340001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t009340001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	OMA
NV2t009340001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t009340001.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t009340001.1	cellular_component	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	"A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]	OMA
NV2t009340001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009340001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009340001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t009340002.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t009340002.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t009340002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009340002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009340003.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t009340003.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t009340003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009340003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009340004.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t009340004.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t009341001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009341001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009341002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009341002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009341003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009341003.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009343001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t009343001.1	molecular_function	GO:0004407	histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [PMID:9893272, RHEA:58196]	OMA
NV2t009344001.1	biological_process	GO:0016441	post-transcriptional gene silencing	"The inactivation of gene expression that occurs after transcription." [GOC:mah, PMID:15020054]	OMA
NV2t009344001.1	biological_process	GO:0042742	defense response to bacterium	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]	OMA
NV2t009344001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	OMA
NV2t009344001.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t009344001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009344001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009344001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t009344001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t009344001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009344001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009344001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t009344001.1	molecular_function	GO:0008143	poly(A) binding	"Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]	OMA
NV2t009344001.1	molecular_function	GO:0008266	poly(U) RNA binding	"Binding to a sequence of uracil residues in an RNA molecule." [GOC:mah]	OMA
NV2t009344002.1	biological_process	GO:0098789	obsolete pre-mRNA cleavage required for polyadenylation	"OBSOLETE. The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_]	PANTHER
NV2t009344002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009344002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009345001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009345001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009345002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t009345002.1	biological_process	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	OMA
NV2t009345002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009345002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009345002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009345002.1	molecular_function	GO:0031386	protein tag activity	"A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]	OMA
NV2t009345002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t009345002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009345003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009345003.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009345004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009345004.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009345005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009345005.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t009348001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t009348001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t009348001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t009348002.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t009348002.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t009348003.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t009348003.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t009348003.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t009348004.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t009348004.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t009348006.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t009348006.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t009348007.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t009348007.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t009348008.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t009348008.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t009348009.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t009348010.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t009348010.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t009349001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t009349001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t009349001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t009349001.1	cellular_component	GO:0001652	granular component	"A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561]	OMA
NV2t009349001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t009349001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t009349001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t009349002.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t009350001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t009350001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t009350001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t009350001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009350001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t009350001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t009351001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009351001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t009352001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009354001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t009354001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t009354001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t009354001.1	biological_process	GO:0034969	obsolete histone arginine methylation	"OBSOLETE. The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah]	PANTHER
NV2t009354001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009354001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009354001.1	molecular_function	GO:0008469	histone arginine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [PMID:8002954]	OMA
NV2t009355001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t009355001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t009355001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t009355001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t009355001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t009355001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t009359001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009363001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363009.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363010.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363011.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363014.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363015.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363016.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363017.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363017.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009363018.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363019.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009363020.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009367002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009367003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009367005.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t009369001.1	biological_process	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	InterPro
NV2t009369002.1	biological_process	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	InterPro
NV2t009370001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009370001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t009370001.1	biological_process	GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle	"Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t009370001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t009370001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009370001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009371004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371009.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371010.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371011.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371012.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371012.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009371013.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371014.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371015.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009371016.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009377001.1	biological_process	GO:0006062	sorbitol catabolic process	"The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732]	OMA
NV2t009377001.1	biological_process	GO:0006062	sorbitol catabolic process	"The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732]	PANTHER
NV2t009377001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t009377001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t009377001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t009377001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t009377001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t009377001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t009377001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t009377001.1	molecular_function	GO:0003939	L-iditol 2-dehydrogenase activity	"Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14]	OMA
NV2t009377001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009377001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t009377001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t009377001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t009377001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t009378001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t009378001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009379001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t009379001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009379001.1	molecular_function	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t009379002.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t009379002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009380002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009380003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009380004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009384001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t009384001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009386001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t009386001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t009388001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009388001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009388002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009388002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009391001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009391001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009392001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009392001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009402001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009402002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009403001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	PANTHER
NV2t009403001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t009416001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009416002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009416003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009417001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009417001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t009417001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t009417001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009417001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t009417001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t009417001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009417001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t009417001.1	molecular_function	GO:0004711	ribosomal protein S6 kinase activity	"Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]	OMA
NV2t009417001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009417001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009417002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009417002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t009417002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009417002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009417003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009417003.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t009417003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009417003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009417004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009417004.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t009417004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009417004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009417005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009417005.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t009417005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009418001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009418001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t009419001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009419001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	PANTHER
NV2t009419001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t009419001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t009420001.1	biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]	PANTHER
NV2t009421001.1	biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]	PANTHER
NV2t009424001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t009424001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009424002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t009424002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009424002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009424002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t009424002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t009424002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009424002.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t009424003.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t009424003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009427001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t009427001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009427001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t009427001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t009427001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009427002.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t009428001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	OMA
NV2t009428001.1	biological_process	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	InterPro
NV2t009428001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t009428001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009428001.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t009428001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009429001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t009440001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009440002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009446001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t009446001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009446001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009446001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009454001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t009454001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009460001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009460001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009467001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009467001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t009467001.1	biological_process	GO:0044773	mitotic DNA damage checkpoint signaling	"A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]	OMA
NV2t009467001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009467001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009467001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t009467001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	PANTHER
NV2t009467001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009468001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009469001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009469001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t009474001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t009474001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t009474001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	OMA
NV2t009484001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t009484001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t009484001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	PANTHER
NV2t009484001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t009484001.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	OMA
NV2t009485001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009485001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009485001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009490001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t009490001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009490001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009490001.1	cellular_component	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t009490001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t009493001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009494001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009496001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009496001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009496001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009505002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t009505002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t009505002.1	cellular_component	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	OMA
NV2t009505002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009505002.1	molecular_function	GO:0031681	G-protein beta-subunit binding	"Binding to a G-protein beta subunit." [GOC:mah]	InterPro
NV2t009506001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009506001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t009506001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t009506001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t009506002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009506002.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t009506003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009506003.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t009507001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t009508001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t009508001.1	biological_process	GO:0060465	pharynx development	"The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk]	OMA
NV2t009508001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t009510001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009510001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009511001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t009516001.1	biological_process	GO:0009650	UV protection	"Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]	OMA
NV2t009516001.1	biological_process	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	OMA
NV2t009516001.1	biological_process	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	OMA
NV2t009516001.1	biological_process	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	OMA
NV2t009516001.1	biological_process	GO:0042542	response to hydrogen peroxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]	OMA
NV2t009516001.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	InterPro
NV2t009516001.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	OMA
NV2t009516001.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	PANTHER
NV2t009516001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t009516001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t009516001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t009516001.1	biological_process	GO:0061687	detoxification of inorganic compound	"Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw]	OMA
NV2t009516001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t009516001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t009516001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t009516001.1	molecular_function	GO:0004096	catalase activity	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]	InterPro
NV2t009516001.1	molecular_function	GO:0004096	catalase activity	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]	OMA
NV2t009516001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t009516001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009516001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t009516001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t009516001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t009516002.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	PANTHER
NV2t009516002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009516003.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	InterPro
NV2t009516003.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	PANTHER
NV2t009516003.1	molecular_function	GO:0004096	catalase activity	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]	InterPro
NV2t009516003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009516004.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	InterPro
NV2t009516004.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	PANTHER
NV2t009516004.1	molecular_function	GO:0004096	catalase activity	"Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6]	InterPro
NV2t009516004.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009517001.1	biological_process	GO:0008218	bioluminescence	"The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]	InterPro
NV2t009517001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t009526001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t009527001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009529001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009531001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009531001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009531001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009532001.1	molecular_function	GO:1990050	phosphatidic acid transfer activity	"Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]	PANTHER
NV2t009532002.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t009532002.1	molecular_function	GO:1990050	phosphatidic acid transfer activity	"Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]	PANTHER
NV2t009533001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009534001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t009535001.1	biological_process	GO:1901222	regulation of non-canonical NF-kappaB signal transduction	"Any process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade." [GOC:TermGenie]	InterPro
NV2t009535001.1	biological_process	GO:1901222	regulation of non-canonical NF-kappaB signal transduction	"Any process that modulates the frequency, rate or extent of the non-canonical NF-kappaB signaling cascade." [GOC:TermGenie]	OMA
NV2t009538001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t009538001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t009540001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t009540001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t009540001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t009541001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t009541001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009541001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009541001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009541002.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t009541002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009541002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009541002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009541003.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t009541003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009541003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009541003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009541004.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t009541004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009542001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t009542001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009542001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t009542001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t009542001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	PANTHER
NV2t009542001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009542001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t009542001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t009542002.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t009542003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t009542003.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t009542004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t009542004.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t009543001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t009544001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t009545001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t009546001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t009546001.1	biological_process	GO:0018126	protein hydroxylation	"The addition of a hydroxy group to a protein amino acid." [GOC:ai]	OMA
NV2t009546001.1	biological_process	GO:0018197	peptidyl-aspartic acid modification	"The modification of peptidyl-aspartic acid." [GOC:ma]	OMA
NV2t009546001.1	biological_process	GO:0018202	peptidyl-histidine modification	"The modification of peptidyl-histidine." [GOC:ma]	OMA
NV2t009546001.1	biological_process	GO:0043618	obsolete regulation of transcription from RNA polymerase II promoter in response to stress	"OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]	OMA
NV2t009546001.1	biological_process	GO:0045746	negative regulation of Notch signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t009546001.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	OMA
NV2t009546001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009546001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009546001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t009546001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t009546001.1	molecular_function	GO:0071532	ankyrin repeat binding	"Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure." [GOC:mah, InterPro:IPR002110]	PANTHER
NV2t009546001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t009547001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009547001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t009550001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	OMA
NV2t009550001.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t009550001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009551001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t009551001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t009551001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t009551001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t009553001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009562001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t009562001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009562001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	InterPro
NV2t009562001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t009562002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t009562002.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	InterPro
NV2t009563001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t009563001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t009563001.1	biological_process	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	OMA
NV2t009563001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t009563001.1	biological_process	GO:0022414	reproductive process	"A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]	OMA
NV2t009563001.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	OMA
NV2t009563001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t009563001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t009563001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t009563001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t009563001.1	biological_process	GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t009563001.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t009563001.1	biological_process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t009563001.1	cellular_component	GO:0000159	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	OMA
NV2t009563001.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	OMA
NV2t009563001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009563001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t009563001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t009563001.1	cellular_component	GO:0150034	distal axon	"That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468]	OMA
NV2t009563001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t009563001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t009563001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t009563001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t009563001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t009568001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t009568001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009569001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009569001.1	biological_process	GO:0035329	hippo signaling	"An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation." [PMID:17318211, PMID:18328423, PMID:36347846]	InterPro
NV2t009569001.1	biological_process	GO:0035329	hippo signaling	"An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation." [PMID:17318211, PMID:18328423, PMID:36347846]	OMA
NV2t009569001.1	biological_process	GO:0048568	embryonic organ development	"Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	PANTHER
NV2t009569001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t009569002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009569002.1	biological_process	GO:0048568	embryonic organ development	"Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	PANTHER
NV2t009569003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009569003.1	biological_process	GO:0048568	embryonic organ development	"Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	PANTHER
NV2t009573001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t009573001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009573002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t009573002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009573003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t009573003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009576001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009576001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009576002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009576002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009576003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009576003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009576004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009576004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009576005.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009576005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009576006.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009576006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009578001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009578001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t009595001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t009595001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t009595001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t009599001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009599001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t009600001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t009600001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t009600001.1	biological_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t009600001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009600001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t009600001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t009600001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t009600001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t009600002.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t009600002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009600003.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t009600003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009601001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t009606001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009606001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t009606001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t009614001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t009614001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t009614001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t009614001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t009614001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t009615001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009616001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t009616001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t009616001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t009616001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t009618001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009618001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009618001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009618001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t009618001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t009619001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009619002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009619003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009619003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009619003.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009622001.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t009622001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t009622001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t009622001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009622001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t009622001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t009624001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009624001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009624001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t009624001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t009626001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009627001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t009627001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t009629001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009629001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009629002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009629002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009630001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t009630001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009630001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t009631001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009631001.1	biological_process	GO:0098656	monoatomic anion transmembrane transport	"The process in which a monoatomic anion is transported across a membrane. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	InterPro
NV2t009631001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t009631001.1	molecular_function	GO:0008308	voltage-gated monoatomic anion channel activity	"Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729]	OMA
NV2t009634001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009637001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009638001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009638002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009646001.1	biological_process	GO:0070932	obsolete histone H3 deacetylation	"OBSOLETE. The modification of histone H3 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl]	PANTHER
NV2t009646001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t009646002.1	biological_process	GO:0070932	obsolete histone H3 deacetylation	"OBSOLETE. The modification of histone H3 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl]	PANTHER
NV2t009646002.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t009648001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t009648001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t009648001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t009648001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t009655001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t009656001.1	biological_process	GO:0050728	negative regulation of inflammatory response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]	PANTHER
NV2t009656001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t009657001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	InterPro
NV2t009657001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	OMA
NV2t009657001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	PANTHER
NV2t009657001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t009665001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t009665001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t009667001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t009667001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t009667001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t009667001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t009667001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t009667001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t009667001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t009667002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t009667002.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t009668001.1	biological_process	GO:0006559	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	InterPro
NV2t009668001.1	biological_process	GO:0006559	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	OMA
NV2t009668001.1	biological_process	GO:0009072	aromatic amino acid metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	InterPro
NV2t009668001.1	molecular_function	GO:0004505	phenylalanine 4-monooxygenase activity	"Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [PMID:4004813, RHEA:20273]	OMA
NV2t009668001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t009668001.1	molecular_function	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t009668002.1	biological_process	GO:0006559	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	InterPro
NV2t009668002.1	biological_process	GO:0009072	aromatic amino acid metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	InterPro
NV2t009668002.1	molecular_function	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t009668003.1	biological_process	GO:0006559	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	InterPro
NV2t009668003.1	biological_process	GO:0009072	aromatic amino acid metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	InterPro
NV2t009668003.1	molecular_function	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t009668004.1	biological_process	GO:0006559	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	InterPro
NV2t009668004.1	biological_process	GO:0009072	aromatic amino acid metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	InterPro
NV2t009668004.1	molecular_function	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t009668005.1	biological_process	GO:0009072	aromatic amino acid metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	InterPro
NV2t009668005.1	molecular_function	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t009670001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009672001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009672001.1	molecular_function	GO:0035497	cAMP response element binding	"Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470]	PANTHER
NV2t009673001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009673001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009673001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t009675001.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t009675001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t009675001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t009675001.1	biological_process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	"The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels." [GOC:curators]	OMA
NV2t009675001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t009675001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t009675001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t009675001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t009675001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t009675001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009675001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t009675001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t009675001.1	cellular_component	GO:0031045	dense core granule	"Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495]	OMA
NV2t009675001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t009675001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009675001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t009675001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t009675001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t009676001.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t009676001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t009676001.1	biological_process	GO:0046928	regulation of neurotransmitter secretion	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]	OMA
NV2t009676001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t009676001.1	biological_process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	"The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels." [GOC:curators]	OMA
NV2t009676001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t009676001.1	biological_process	GO:0060291	long-term synaptic potentiation	"A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph]	OMA
NV2t009676001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t009676001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t009676001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t009676001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t009676001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009676001.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	OMA
NV2t009676001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t009676001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009676001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t009676001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t009676001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t009678001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t009678001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009682001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t009685001.1	biological_process	GO:0006623	protein targeting to vacuole	"The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]	InterPro
NV2t009685001.1	biological_process	GO:0006623	protein targeting to vacuole	"The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t009685001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t009685001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t009685001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t009685001.1	cellular_component	GO:0035658	Mon1-Ccz1 complex	"A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862]	OMA
NV2t009685001.1	cellular_component	GO:0035658	Mon1-Ccz1 complex	"A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862]	PANTHER
NV2t009685001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t009687001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t009687001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009687001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t009687001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t009688001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t009688001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009688001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009689001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t009689001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t009689001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t009689001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t009689001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009689001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t009689001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t009691001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t009691001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009691001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009691001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t009691001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t009691001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t009691001.1	molecular_function	GO:0004890	GABA-A receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]	OMA
NV2t009691001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t009691001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t009691001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t009691001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t009693001.1	biological_process	GO:0006307	DNA alkylation repair	"The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases." [PMID:10946226, PMID:35543797]	OMA
NV2t009693001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009693001.1	molecular_function	GO:0051213	dioxygenase activity	"Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]	InterPro
NV2t009693001.1	molecular_function	GO:0051213	dioxygenase activity	"Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]	OMA
NV2t009695001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009695001.1	cellular_component	GO:0070603	SWI/SNF superfamily-type complex	"A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]	PANTHER
NV2t009695001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t009695002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t009695002.1	cellular_component	GO:0070603	SWI/SNF superfamily-type complex	"A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]	PANTHER
NV2t009695002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t009696001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009697001.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t009697001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t009697001.1	biological_process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]	OMA
NV2t009697001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t009697001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009697002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009697003.1	molecular_function	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	"Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN]	PANTHER
NV2t009697004.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009698001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009698001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009698001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t009698001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t009698001.1	molecular_function	GO:0050201	fucokinase activity	"Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+." [EC:2.7.1.52, RHEA:13241]	PANTHER
NV2t009698002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009698002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t009698002.1	molecular_function	GO:0050201	fucokinase activity	"Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+." [EC:2.7.1.52, RHEA:13241]	PANTHER
NV2t009698003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009698003.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t009698003.1	molecular_function	GO:0050201	fucokinase activity	"Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+." [EC:2.7.1.52, RHEA:13241]	PANTHER
NV2t009698004.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009698004.1	molecular_function	GO:0050201	fucokinase activity	"Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+." [EC:2.7.1.52, RHEA:13241]	PANTHER
NV2t009705001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t009705001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t009705001.1	biological_process	GO:1901214	obsolete regulation of neuron death	"OBSOLETE. Any process that modulates the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t009705001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009705001.1	molecular_function	GO:0003925	G protein activity	"A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]	OMA
NV2t009705001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009705001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t009705001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t009705001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t009706001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t009706001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009706001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009708001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t009708001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009708001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009708001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t009708001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t009708001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t009708001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t009708001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t009708001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t009708001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t009709001.1	biological_process	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]	PANTHER
NV2t009709001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009709002.1	biological_process	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]	PANTHER
NV2t009709002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009709003.1	biological_process	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]	PANTHER
NV2t009709003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009709004.1	biological_process	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]	PANTHER
NV2t009709004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009709005.1	biological_process	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]	PANTHER
NV2t009709005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009709006.1	biological_process	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]	PANTHER
NV2t009709006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009709007.1	biological_process	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]	PANTHER
NV2t009709007.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009709007.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t009710001.1	biological_process	GO:0019725	cellular homeostasis	"Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]	OMA
NV2t009710001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t009710001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t009710001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t009710001.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t009710001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009710001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t009711001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009711001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009711001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009711001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t009711001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009711002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009711002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t009711002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009711002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009711002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t009711002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t009711002.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t009711002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009711003.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009711003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009711003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009711003.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t009711003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009711004.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009711004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009711004.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009711004.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t009711004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009711005.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009711005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009711005.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009711005.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t009711005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009711006.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009711006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009711006.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009711006.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t009711006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009711007.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009711007.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009711007.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009711007.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t009711007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009711008.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009711008.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009711008.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t009711008.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t009711008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009712002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009713001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t009713001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t009713001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t009713001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t009713001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t009713001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t009717001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t009717001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009717001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009717001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009718001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009720001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t009720001.1	biological_process	GO:0006165	obsolete nucleoside diphosphate phosphorylation	"OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	OMA
NV2t009720001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t009720001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	OMA
NV2t009720001.1	biological_process	GO:0007286	spermatid development	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]	OMA
NV2t009720001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t009720001.1	biological_process	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t009720001.1	biological_process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522]	PANTHER
NV2t009720001.1	biological_process	GO:1903202	obsolete negative regulation of oxidative stress-induced cell death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	OMA
NV2t009720001.1	biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t009720001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t009720001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t009721001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t009721001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t009721001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t009721001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009721001.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t009721001.1	cellular_component	GO:0034719	SMN-Sm protein complex	"A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408]	OMA
NV2t009721001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t009721001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009721001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t009721002.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t009721002.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t009721002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009721003.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t009721003.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t009721003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t009723001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t009723001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t009724001.1	biological_process	GO:0006858	extracellular transport	"The transport of substances that occurs outside cells." [GOC:go_curators]	OMA
NV2t009724001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t009724001.1	biological_process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]	OMA
NV2t009724001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t009724001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t009724001.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t009724001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t009724001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t009724001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t009724001.1	biological_process	GO:0040008	regulation of growth	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]	OMA
NV2t009724001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t009724001.1	biological_process	GO:0043405	regulation of MAP kinase activity	"Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t009724001.1	biological_process	GO:0044000	obsolete movement in host	"OBSOLETE. The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]	OMA
NV2t009724001.1	biological_process	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	OMA
NV2t009724001.1	biological_process	GO:0044089	positive regulation of cellular component biogenesis	"Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t009724001.1	biological_process	GO:0045921	positive regulation of exocytosis	"Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t009724001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t009724001.1	biological_process	GO:1902115	regulation of organelle assembly	"Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]	OMA
NV2t009724001.1	biological_process	GO:1903902	positive regulation of viral life cycle	"Any process that activates or increases the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716]	OMA
NV2t009724001.1	cellular_component	GO:0000813	ESCRT I complex	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]	OMA
NV2t009724001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009724001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t009724001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t009724001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009724001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t009724001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t009724001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t009724001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t009724001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t009724001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t009724001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t009724001.1	molecular_function	GO:0046790	virion binding	"Binding to a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai]	OMA
NV2t009724001.1	molecular_function	GO:0048306	calcium-dependent protein binding	"Binding to a protein or protein complex in the presence of calcium." [GOC:jid, PMID:10485905]	OMA
NV2t009724002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t009724002.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t009725001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009727001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009727001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t009727001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t009729001.1	biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t009729002.1	biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t009730001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009730001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009730001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009730001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009730001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t009730002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009730002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009751001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t009751001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t009751002.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t009751002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009751002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009751002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009751003.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t009751003.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t009752001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t009752001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009752001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009752001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009752001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t009756001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009757001.1	biological_process	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	OMA
NV2t009757001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t009757001.1	molecular_function	GO:0090729	toxin activity	"Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom." [GOC:pt]	InterPro
NV2t009759001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t009759001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009759001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009761001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t009762001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t009763001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t009764001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t009764001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t009764001.1	biological_process	GO:0031532	obsolete actin cytoskeleton reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]	OMA
NV2t009764001.1	biological_process	GO:0034446	substrate adhesion-dependent cell spreading	"The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732]	OMA
NV2t009764001.1	biological_process	GO:0034446	substrate adhesion-dependent cell spreading	"The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732]	PANTHER
NV2t009764001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t009764001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t009764001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009764001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t009764001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t009764001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t009764001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009765002.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765003.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765004.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765005.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765006.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765007.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765008.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765009.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765010.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765012.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765013.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765014.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765017.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765018.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765019.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765020.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765021.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765022.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765024.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765025.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765026.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765027.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765028.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765029.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765030.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765031.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765032.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765033.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765034.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765035.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765042.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765043.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765044.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765045.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765046.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765047.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765048.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765051.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009765052.1	biological_process	GO:0002183	cytoplasmic translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]	OMA
NV2t009765052.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t009765052.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009765052.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t009765052.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t009765052.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t009765052.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t009765052.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t009767001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t009768001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t009768001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009769001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t009769001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009769002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t009771001.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	PANTHER
NV2t009771001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009771001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009771002.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	PANTHER
NV2t009771002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009771002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t009772001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t009773001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t009773002.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t009773003.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t009773004.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t009775001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009775001.1	biological_process	GO:0046340	diacylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11717312]	PANTHER
NV2t009775002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009775002.1	biological_process	GO:0046340	diacylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11717312]	PANTHER
NV2t009775003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009775003.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t009775003.1	biological_process	GO:0046340	diacylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11717312]	PANTHER
NV2t009775003.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	OMA
NV2t009778001.1	cellular_component	GO:1990385	meiotic spindle midzone	"The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv, PMID:12707312]	PANTHER
NV2t009780001.1	biological_process	GO:0006166	purine ribonucleoside salvage	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]	InterPro
NV2t009780002.1	biological_process	GO:0006166	purine ribonucleoside salvage	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]	InterPro
NV2t009781001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t009781002.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t009781003.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t009781004.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t009784001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t009784001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t009784001.1	cellular_component	GO:0008250	oligosaccharyltransferase complex	"A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887]	PANTHER
NV2t009784001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t009784001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t009784001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t009785001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009785001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	PANTHER
NV2t009785002.1	biological_process	GO:0000086	G2/M transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]	OMA
NV2t009785002.1	biological_process	GO:0006275	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	OMA
NV2t009785002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009785002.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t009785002.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t009785002.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	PANTHER
NV2t009785002.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t009785002.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t009785002.1	biological_process	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t009785002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t009785002.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t009785002.1	biological_process	GO:0031325	positive regulation of cellular metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t009785002.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t009785002.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t009785002.1	biological_process	GO:0051173	obsolete positive regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t009785002.1	biological_process	GO:0090068	positive regulation of cell cycle process	"Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t009785002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009785002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009785002.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t009785002.1	molecular_function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	"Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]	OMA
NV2t009785002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009785002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009785002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009785002.1	molecular_function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	"Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II." [EC:2.7.11.23, GOC:mah, PMID:28248323]	OMA
NV2t009786001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t009786001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009786001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009786001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009790001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t009790001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009790001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t009790001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t009790001.1	molecular_function	GO:0022824	transmitter-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t009790001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t009790001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t009791001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t009791001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009791001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t009791001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t009791001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t009808001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t009810001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009811001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t009811001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t009811001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t009813001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t009813001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009813001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t009813001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t009815001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009822001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009822001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009828001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	OMA
NV2t009828001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	PANTHER
NV2t009828001.1	biological_process	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t009828001.1	biological_process	GO:0010587	miRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]	OMA
NV2t009828001.1	biological_process	GO:0031047	regulatory ncRNA-mediated gene silencing	"A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation." [PMID:15020054]	InterPro
NV2t009828001.1	biological_process	GO:0031047	regulatory ncRNA-mediated gene silencing	"A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation." [PMID:15020054]	OMA
NV2t009828001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009828001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009828001.1	cellular_component	GO:0016442	RISC complex	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]	OMA
NV2t009828001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t009828001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t009828001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009828001.1	molecular_function	GO:1905172	RISC complex binding	"Binding to a RISC complex." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24882364]	OMA
NV2t009839001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t009839001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t009840001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009840001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009842001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t009842001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t009842001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t009842001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t009842001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t009842001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t009844001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t009844001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009844001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t009844002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t009844002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009844002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t009844003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t009844003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009844004.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t009844004.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009844004.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t009844005.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t009844005.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009844005.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t009845001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009845001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t009845002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009848001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009848001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t009848001.1	biological_process	GO:0110031	negative regulation of G2/MI transition of meiotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408]	PANTHER
NV2t009848001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t009848001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t009848001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009848001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009849001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t009849001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009849001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009849002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t009849002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009849002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009849003.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t009851001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t009855001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009855001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t009856001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t009857001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t009857001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t009857001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t009857001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t009857001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t009858001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t009858001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t009858001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t009858001.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t009858001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t009858001.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t009858001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t009858001.1	molecular_function	GO:0033549	MAP kinase phosphatase activity	"Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316]	OMA
NV2t009859001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009859001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t009859002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009859002.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t009859003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t009859003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009859003.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	OMA
NV2t009859003.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t009859003.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t009859003.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t009859004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009859004.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t009859004.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t009859005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009859005.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t009859005.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t009859006.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t009859006.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t009859007.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t009859007.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t009860001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t009860001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t009860002.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t009860002.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t009861001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t009861001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009868001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t009868001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	PANTHER
NV2t009868001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t009868001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t009868001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t009869001.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t009869001.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	OMA
NV2t009869001.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t009869001.1	molecular_function	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	"Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13]	OMA
NV2t009875001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	OMA
NV2t009875001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	PANTHER
NV2t009876001.1	biological_process	GO:0000002	mitochondrial genome maintenance	"The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]	OMA
NV2t009876001.1	biological_process	GO:0006206	pyrimidine nucleobase metabolic process	"The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	InterPro
NV2t009876001.1	biological_process	GO:0006206	pyrimidine nucleobase metabolic process	"The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	OMA
NV2t009876001.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	OMA
NV2t009876001.1	biological_process	GO:0044058	regulation of digestive system process	"Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl]	OMA
NV2t009876001.1	biological_process	GO:0051960	regulation of nervous system development	"Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	OMA
NV2t009876001.1	biological_process	GO:0051969	regulation of transmission of nerve impulse	"Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]	OMA
NV2t009876001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009876001.1	molecular_function	GO:0004645	1,4-alpha-oligoglucan phosphorylase activity	"Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1]	OMA
NV2t009876001.1	molecular_function	GO:0016154	pyrimidine-nucleoside phosphorylase activity	"Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2]	InterPro
NV2t009876001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009876001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t009876001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t009876001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t009876002.1	biological_process	GO:0006206	pyrimidine nucleobase metabolic process	"The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	InterPro
NV2t009876002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t009876002.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t009877001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t009877001.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t009877001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	OMA
NV2t009877001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t009877001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t009877001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	PANTHER
NV2t009878001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t009878001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t009878001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t009879001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009879001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009879001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009879001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009879002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009879002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009879003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009879003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009882001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t009882001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t009882001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t009884001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t009884001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t009885001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t009885001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t009885001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t009887001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009887001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009887001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009888001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009888001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009888001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009888001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009888002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009888002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009890001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009890001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009890001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t009892001.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t009892001.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	OMA
NV2t009892001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t009892001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t009892001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t009892001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t009892001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t009892001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t009892001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009892001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t009892001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009892001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t009892001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t009892001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009892001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	InterPro
NV2t009892001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t009892001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t009894001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009894001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	PANTHER
NV2t009896001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t009898001.1	biological_process	GO:0006084	acetyl-CoA metabolic process	"The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]	OMA
NV2t009898001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	InterPro
NV2t009898001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t009898001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t009898001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t009898001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t009898001.1	biological_process	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	OMA
NV2t009898001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t009898001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009898001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t009898001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	InterPro
NV2t009898001.1	molecular_function	GO:0016885	ligase activity, forming carbon-carbon bonds	"Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-, GOC:jl, GOC:mah]	OMA
NV2t009898001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t009898001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t009898001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t009900001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t009900001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t009900001.1	molecular_function	GO:0048101	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	"Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin." [GOC:jid]	PANTHER
NV2t009901003.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t009901003.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t009901003.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t009901003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009902001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009902001.1	biological_process	GO:0046473	phosphatidic acid metabolic process	"The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]	OMA
NV2t009902001.1	biological_process	GO:0046474	glycerophospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t009902001.1	biological_process	GO:0048017	obsolete inositol lipid-mediated signaling	"OBSOLETE. The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids." [GOC:bf, GOC:ceb, PMID:16088939]	OMA
NV2t009902001.1	biological_process	GO:0060627	regulation of vesicle-mediated transport	"Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]	PANTHER
NV2t009902001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009902001.1	molecular_function	GO:0004630	phospholipase D activity	"Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4]	OMA
NV2t009902001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t009902001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t009902002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009902002.1	biological_process	GO:0060627	regulation of vesicle-mediated transport	"Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]	PANTHER
NV2t009902002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009902002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t009902003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t009902003.1	biological_process	GO:0060627	regulation of vesicle-mediated transport	"Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]	PANTHER
NV2t009902003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t009902003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t009904001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t009904001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009904001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009904001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009908001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009908002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009908002.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t009908003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009908004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009911001.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t009911001.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	OMA
NV2t009911001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t009911001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t009911001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t009911001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t009911001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t009911001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t009911001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009911001.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	OMA
NV2t009911001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t009911001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009911001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t009911001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t009911001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t009912001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t009912001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t009912001.1	biological_process	GO:0051096	positive regulation of helicase activity	"Any process that activates or increases the activity of a helicase." [GOC:ai]	PANTHER
NV2t009912001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	InterPro
NV2t009912001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t009914001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t009914001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t009914001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009914001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t009914001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t009914001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t009914001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t009915001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009915001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009916001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009916001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t009916002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009916003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t009917001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009917002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009918001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t009918003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t009919001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t009919001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t009919001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t009922001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009922001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009922001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009922001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t009923001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009923001.1	biological_process	GO:0060296	regulation of cilium beat frequency involved in ciliary motility	"Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:BHF, GOC:cilia, GOC:dph, GOC:krc, GOC:tb]	PANTHER
NV2t009923002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009923002.1	biological_process	GO:0060296	regulation of cilium beat frequency involved in ciliary motility	"Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:BHF, GOC:cilia, GOC:dph, GOC:krc, GOC:tb]	PANTHER
NV2t009925001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t009927001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t009927001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	PANTHER
NV2t009927001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009928001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t009928001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t009928001.1	cellular_component	GO:0071006	U2-type catalytic step 1 spliceosome	"A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t009928001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t009928001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t009928001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t009928002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t009930001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t009932001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t009932001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t009932001.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	InterPro
NV2t009932001.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	OMA
NV2t009935001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t009935001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009935001.1	molecular_function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr]	OMA
NV2t009936001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t009936001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009936001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t009936001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t009936001.1	cellular_component	GO:0008541	proteasome regulatory particle, lid subcomplex	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]	PANTHER
NV2t009936001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t009938001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t009939001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009939001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009940001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009940001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009940001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009941001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009943001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t009943001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009943001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t009943001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t009943001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t009945001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t009945001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t009950001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t009950001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t009950001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t009950001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t009952001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009968001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t009968001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009968001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t009968002.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t009968002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009968003.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t009968003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009970001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t009971001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t009971001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t009972001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t009972001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t009972001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	InterPro
NV2t009972001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	OMA
NV2t009972001.1	biological_process	GO:0009052	pentose-phosphate shunt, non-oxidative branch	"The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY]	PANTHER
NV2t009972001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t009972001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t009972001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009972001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t009973001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t009973001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t009973001.1	biological_process	GO:0009409	response to cold	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]	OMA
NV2t009973001.1	biological_process	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t009973001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t009973001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t009973001.1	biological_process	GO:0071396	cellular response to lipid	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]	OMA
NV2t009973001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t009973001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	OMA
NV2t009973001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t009973001.1	biological_process	GO:1990845	adaptive thermogenesis	"The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363]	OMA
NV2t009973001.1	biological_process	GO:1990845	adaptive thermogenesis	"The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363]	PANTHER
NV2t009973001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t009973001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t009976002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t009977001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t009977001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t009977001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t009977001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009977002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t009987001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t009987001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t009987001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t009993001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009993001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t009993002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009993002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t009993003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009993003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t009994001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t009994001.1	biological_process	GO:0007006	mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t009994001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t009994001.1	biological_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t009994001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t009994001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t009994001.1	biological_process	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	"The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:sm]	OMA
NV2t009994001.1	biological_process	GO:0010823	obsolete negative regulation of mitochondrion organization	"OBSOLETE. Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	OMA
NV2t009994001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t009994001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	OMA
NV2t009994001.1	biological_process	GO:0034644	cellular response to UV	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]	OMA
NV2t009994001.1	biological_process	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	OMA
NV2t009994001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009994001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t009994001.1	biological_process	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t009994001.1	biological_process	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	OMA
NV2t009994001.1	biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]	OMA
NV2t009994001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t009994001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t009994001.1	biological_process	GO:0097202	activation of cysteine-type endopeptidase activity	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:21726810]	OMA
NV2t009994001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t009994001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t009994001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t009994001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t009994001.1	molecular_function	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	OMA
NV2t009994001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t009994002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009994002.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t009994003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009994003.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t009994004.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009994004.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t009994005.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009994005.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t009994006.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009994006.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t009994007.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009994007.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t009994008.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t009994008.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t009996001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t009996001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009996001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t009996001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t009998001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t009998001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t009998001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t010004001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t010005001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	OMA
NV2t010005001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t010005001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t010005001.1	molecular_function	GO:0039706	co-receptor binding	"Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell." [GOC:bf, GOC:jl]	OMA
NV2t010005001.1	molecular_function	GO:0048019	receptor antagonist activity	"The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor." [GOC:ceb, ISBN:0198506732]	OMA
NV2t010006001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	InterPro
NV2t010006001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t010007001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t010007001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t010007001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010007001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010007002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t010007002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010021001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t010021001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010021002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t010021002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010021003.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t010021003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010022001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t010022001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t010022002.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	PANTHER
NV2t010022002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t010023001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t010023001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010023002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t010023002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010023003.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t010023003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010023004.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t010023004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010023005.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t010023005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010023006.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t010023006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010023007.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t010023007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010023008.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t010023008.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010023009.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010024001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010024001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010024002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010024002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010031001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	InterPro
NV2t010031001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	OMA
NV2t010031001.1	biological_process	GO:1903744	positive regulation of anterograde synaptic vesicle transport	"Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25329901]	PANTHER
NV2t010032001.1	biological_process	GO:0032388	positive regulation of intracellular transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t010032001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	InterPro
NV2t010032001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	OMA
NV2t010032001.1	biological_process	GO:0060632	regulation of microtubule-based movement	"Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]	OMA
NV2t010032001.1	biological_process	GO:0072384	organelle transport along microtubule	"The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah]	OMA
NV2t010032001.1	biological_process	GO:1903744	positive regulation of anterograde synaptic vesicle transport	"Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25329901]	PANTHER
NV2t010032001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t010032001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t010032001.1	cellular_component	GO:0098574	cytoplasmic side of lysosomal membrane	"The side (leaflet) of the lysosomal membrane that faces the cytoplasm." [GOC:ab, GOC:dos]	OMA
NV2t010032001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t010036001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010036001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010036001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010036001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010037001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t010037001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t010037001.1	biological_process	GO:0045859	regulation of protein kinase activity	"Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t010037001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t010037001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010037001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t010037001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t010037001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t010037001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	OMA
NV2t010037001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t010037001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t010037001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t010039001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010039001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010039002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010044001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010044001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010044001.1	molecular_function	GO:0001609	G protein-coupled adenosine receptor activity	"Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]	OMA
NV2t010044002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010044002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010046001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t010046001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010046002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t010046002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010046003.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t010046003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010047001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t010047001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010047002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t010047002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010047003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	OMA
NV2t010047003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t010047003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010047003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010047004.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t010047004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010048001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t010048001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010050001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010052001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t010052001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	InterPro
NV2t010052001.1	biological_process	GO:0043966	obsolete histone H3 acetylation	"OBSOLETE. The modification of histone H3 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t010052001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t010052001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010052001.1	cellular_component	GO:0070776	MOZ/MORF histone acetyltransferase complex	"A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]	OMA
NV2t010052001.1	cellular_component	GO:0070776	MOZ/MORF histone acetyltransferase complex	"A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]	PANTHER
NV2t010052001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010052001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t010052001.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	OMA
NV2t010052001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t010052001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010058001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t010058001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010058001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010058001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010062001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t010062001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010062001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t010064002.1	biological_process	GO:0090068	positive regulation of cell cycle process	"Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t010064002.1	biological_process	GO:1901987	regulation of cell cycle phase transition	"Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]	OMA
NV2t010064002.1	biological_process	GO:2000105	positive regulation of DNA-templated DNA replication	"Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication." [GOC:mah]	OMA
NV2t010064002.1	cellular_component	GO:0031431	Dbf4-dependent protein kinase complex	"A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100]	OMA
NV2t010064002.1	molecular_function	GO:0043539	protein serine/threonine kinase activator activity	"Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]	OMA
NV2t010069001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010069001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010069001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t010075001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010075001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010075001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010075001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010075002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010075002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010076001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010076001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010076001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010076001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t010076002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010076002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010078001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010078002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010078002.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t010080001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t010080001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	InterPro
NV2t010080002.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	InterPro
NV2t010080003.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	InterPro
NV2t010081001.1	biological_process	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t010081001.1	biological_process	GO:0009262	deoxyribonucleotide metabolic process	"The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t010081001.1	biological_process	GO:0009264	deoxyribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t010081001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t010081001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	PANTHER
NV2t010081001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t010081001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010081001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t010081001.1	molecular_function	GO:0016832	aldehyde-lyase activity	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators]	OMA
NV2t010081002.1	biological_process	GO:0009264	deoxyribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t010081002.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	PANTHER
NV2t010081002.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t010083001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t010085001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t010085001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t010085001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t010085001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t010085001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t010085001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	InterPro
NV2t010085001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	OMA
NV2t010085001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	PANTHER
NV2t010085001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t010085001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010085001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t010085002.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t010085002.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	InterPro
NV2t010085002.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	PANTHER
NV2t010085002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010085003.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t010085003.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	InterPro
NV2t010085003.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	PANTHER
NV2t010085003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010086001.1	biological_process	GO:0072344	rescue of stalled ribosome	"A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543]	PANTHER
NV2t010086001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010088001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t010088001.1	biological_process	GO:0072344	rescue of stalled ribosome	"A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543]	OMA
NV2t010088001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010088001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010088001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t010088001.1	molecular_function	GO:0005080	protein kinase C binding	"Binding to protein kinase C." [GOC:jl]	OMA
NV2t010088001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t010090001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	OMA
NV2t010090001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010090001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010090001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010090001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010090001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t010090001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t010090001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t010091001.1	biological_process	GO:0042327	positive regulation of phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]	PANTHER
NV2t010091001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010091002.1	biological_process	GO:0042327	positive regulation of phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]	PANTHER
NV2t010091003.1	biological_process	GO:0042327	positive regulation of phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]	PANTHER
NV2t010091004.1	biological_process	GO:0042327	positive regulation of phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]	PANTHER
NV2t010092001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t010094001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010094001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t010094001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010094002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010094003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010094003.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t010094003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010096001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t010096001.1	biological_process	GO:2001136	negative regulation of endocytic recycling	"Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling." [GOC:obol]	PANTHER
NV2t010096002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t010096002.1	biological_process	GO:2001136	negative regulation of endocytic recycling	"Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling." [GOC:obol]	PANTHER
NV2t010096003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t010096003.1	biological_process	GO:2001136	negative regulation of endocytic recycling	"Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling." [GOC:obol]	PANTHER
NV2t010100001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010100001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010100001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t010102001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010102001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010102001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010102001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010107001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010107001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t010107001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010107001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010107001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t010107001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t010107001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t010107001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t010107001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t010110001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t010110001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t010110001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010110001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t010110001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t010110001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010110001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010110001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t010110001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t010110001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t010110001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t010110001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t010111001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t010111001.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	InterPro
NV2t010111001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t010111001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010111001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t010111001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t010111001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t010112001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t010112001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	PANTHER
NV2t010112001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t010112001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t010112001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010112001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t010113001.1	biological_process	GO:0034462	small-subunit processome assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah]	PANTHER
NV2t010113001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010113001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010113001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t010114001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t010114001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010114002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t010114002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010114003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t010114003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010116001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010116001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	OMA
NV2t010116001.1	molecular_function	GO:0050577	GDP-L-fucose synthase activity	"Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]	OMA
NV2t010116001.1	molecular_function	GO:0050577	GDP-L-fucose synthase activity	"Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]	PANTHER
NV2t010116002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010116002.1	molecular_function	GO:0050577	GDP-L-fucose synthase activity	"Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]	PANTHER
NV2t010117001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t010117001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t010117001.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	OMA
NV2t010117001.1	biological_process	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	OMA
NV2t010117001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010117001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t010117001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t010117001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010117001.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	OMA
NV2t010117001.1	molecular_function	GO:0031624	ubiquitin conjugating enzyme binding	"Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]	OMA
NV2t010117001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t010117001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t010117001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t010119001.1	biological_process	GO:0045055	regulated exocytosis	"A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]	PANTHER
NV2t010119001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010120001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t010120001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t010120001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	InterPro
NV2t010120001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	PANTHER
NV2t010121001.1	biological_process	GO:0015804	neutral amino acid transport	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t010121001.1	biological_process	GO:0015811	L-cystine transport	"The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t010121001.1	biological_process	GO:0072348	sulfur compound transport	"The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t010121001.1	cellular_component	GO:0005774	vacuolar membrane	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]	OMA
NV2t010121001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010121001.1	molecular_function	GO:0072349	modified amino acid transmembrane transporter activity	"Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah]	OMA
NV2t010121001.1	molecular_function	GO:1901682	sulfur compound transmembrane transporter activity	"Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t010123001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010124001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t010124002.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t010134001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	InterPro
NV2t010134001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t010134001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t010134001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t010136001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t010136001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t010136001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t010136001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010136001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010136002.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t010136002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010137001.1	biological_process	GO:0030510	regulation of BMP signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]	PANTHER
NV2t010137001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010142001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	PANTHER
NV2t010142001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010143001.1	molecular_function	GO:0090729	toxin activity	"Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom." [GOC:pt]	InterPro
NV2t010144001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t010144001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t010145001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t010145001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t010145001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t010145001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t010145001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010145001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010145001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010146001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010146001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010146001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010152001.1	biological_process	GO:0033962	P-body assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]	PANTHER
NV2t010152002.1	biological_process	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]	OMA
NV2t010152002.1	biological_process	GO:0033962	P-body assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]	OMA
NV2t010152002.1	biological_process	GO:0033962	P-body assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]	PANTHER
NV2t010152002.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t010152002.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	OMA
NV2t010152002.1	molecular_function	GO:0008266	poly(U) RNA binding	"Binding to a sequence of uracil residues in an RNA molecule." [GOC:mah]	OMA
NV2t010152002.1	molecular_function	GO:0070717	poly-purine tract binding	"Binding to a stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah]	OMA
NV2t010152003.1	biological_process	GO:0033962	P-body assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]	PANTHER
NV2t010153001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t010153001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t010153001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t010153001.1	biological_process	GO:0055082	intracellular chemical homeostasis	"A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." [GOC:isa_complete, GOC:jid]	OMA
NV2t010153001.1	cellular_component	GO:0097361	CIA complex	"The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362]	PANTHER
NV2t010153001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t010153001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t010155001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t010155001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t010155001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t010155001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010157001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010157001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010157001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010157002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010157002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010158001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t010158001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t010158001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010160001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010161001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t010162001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t010163001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t010163001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t010163001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t010165001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010165001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t010165001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010171001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010171001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t010171002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010171002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t010171003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010171003.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t010171004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010171004.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t010172001.1	biological_process	GO:0010466	negative regulation of peptidase activity	"Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t010172001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t010172001.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	InterPro
NV2t010172001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t010172001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t010172001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010172002.1	biological_process	GO:0010466	negative regulation of peptidase activity	"Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t010172002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t010172002.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	InterPro
NV2t010172002.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t010172002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010172003.1	biological_process	GO:0010466	negative regulation of peptidase activity	"Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t010172003.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t010172003.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	InterPro
NV2t010172003.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t010172003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010172004.1	biological_process	GO:0010466	negative regulation of peptidase activity	"Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t010172004.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t010172004.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	InterPro
NV2t010172004.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t010172004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010173001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010173001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010173002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010173002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010180001.1	cellular_component	GO:0070319	Golgi to plasma membrane transport vesicle	"A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	PANTHER
NV2t010180001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t010184001.1	biological_process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	InterPro
NV2t010184001.1	biological_process	GO:0046834	lipid phosphorylation	"The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732]	PANTHER
NV2t010184001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010184001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t010185001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010185001.1	molecular_function	GO:0035497	cAMP response element binding	"Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470]	PANTHER
NV2t010185002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010185002.1	molecular_function	GO:0035497	cAMP response element binding	"Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470]	PANTHER
NV2t010185003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010185003.1	molecular_function	GO:0035497	cAMP response element binding	"Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470]	PANTHER
NV2t010186001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t010186001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t010186001.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	OMA
NV2t010186001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010186001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010186001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010186001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t010186001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t010186001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010186001.1	molecular_function	GO:0043548	phosphatidylinositol 3-kinase binding	"Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069]	OMA
NV2t010186002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010186002.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t010187001.1	biological_process	GO:0045747	positive regulation of Notch signaling pathway	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t010187001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t010187001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t010187001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010187001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010187001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t010187002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010188001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t010188001.1	biological_process	GO:0006384	transcription initiation at RNA polymerase III promoter	"A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]	OMA
NV2t010188001.1	biological_process	GO:0006384	transcription initiation at RNA polymerase III promoter	"A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]	PANTHER
NV2t010188001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t010188001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t010188001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t010188001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t010189001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010189001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010189002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010190001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t010190001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t010193001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010193001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t010193001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t010193001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t010193001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010193001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t010194001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010194001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t010194001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t010195001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010195001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010195001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t010195001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t010195001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t010195002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010195002.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010195003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010195003.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010195004.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010195004.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010195005.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010195005.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010200001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t010200001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t010200001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t010200001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t010201001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010201002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010206001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t010206001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t010206001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t010206001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t010206001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t010206001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t010206001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t010206001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t010206001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010206001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t010206002.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t010206002.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t010206002.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t010206003.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t010206003.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t010206003.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t010207001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010207001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t010207001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t010207001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t010208001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010208001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010210001.1	biological_process	GO:0007127	meiosis I	"The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324]	OMA
NV2t010210001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t010210001.1	biological_process	GO:0007292	female gamete generation	"Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732]	OMA
NV2t010210001.1	biological_process	GO:0051308	male meiosis chromosome separation	"The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]	OMA
NV2t010210001.1	biological_process	GO:0051308	male meiosis chromosome separation	"The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]	PANTHER
NV2t010210001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010210001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t010210002.1	biological_process	GO:0051308	male meiosis chromosome separation	"The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]	PANTHER
NV2t010211001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t010211001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t010211001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t010211001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010211001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010212001.1	biological_process	GO:0000738	obsolete DNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]	OMA
NV2t010212001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t010212001.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t010212001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010212001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010212001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010212001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t010212001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t010212001.1	molecular_function	GO:0008296	3'-5'-DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]	OMA
NV2t010212001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t010212001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t010215001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t010215001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t010215001.1	molecular_function	GO:0050194	phosphonoacetaldehyde hydrolase activity	"Catalysis of the reaction: H2O + phosphonoacetaldehyde = acetaldehyde + H+ + phosphate." [EC:3.11.1.1, RHEA:18905]	InterPro
NV2t010217001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	OMA
NV2t010217001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010217001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t010217001.1	molecular_function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t010217001.1	molecular_function	GO:0047598	7-dehydrocholesterol reductase activity	"Catalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH." [RHEA:23984]	PANTHER
NV2t010217002.1	molecular_function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t010217002.1	molecular_function	GO:0047598	7-dehydrocholesterol reductase activity	"Catalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH." [RHEA:23984]	PANTHER
NV2t010217003.1	molecular_function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t010217003.1	molecular_function	GO:0047598	7-dehydrocholesterol reductase activity	"Catalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH." [RHEA:23984]	PANTHER
NV2t010217004.1	molecular_function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t010217004.1	molecular_function	GO:0047598	7-dehydrocholesterol reductase activity	"Catalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH." [RHEA:23984]	PANTHER
NV2t010218001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010218001.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	InterPro
NV2t010218001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010218002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010218002.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	InterPro
NV2t010218002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010218003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010218003.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	InterPro
NV2t010218003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010218004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010218004.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	InterPro
NV2t010218004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010218005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010218005.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	InterPro
NV2t010218005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010218006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010218006.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	InterPro
NV2t010218006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010218007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010218007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t010218007.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	InterPro
NV2t010218007.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	OMA
NV2t010218007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010218007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010218008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010218008.1	molecular_function	GO:0004692	cGMP-dependent protein kinase activity	"cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah]	InterPro
NV2t010218008.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010219001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010219002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010219002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010219002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010220001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010220002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010220003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010225001.1	biological_process	GO:0006828	manganese ion transport	"The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t010225001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t010225001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010225001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t010225001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010225001.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t010225001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010225001.1	molecular_function	GO:0015279	store-operated calcium channel activity	"A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]	OMA
NV2t010225001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t010225001.1	molecular_function	GO:0043178	alcohol binding	"Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]	OMA
NV2t010225001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t010227001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010227001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010228001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010228001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010228001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010230001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010230001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010230001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010234002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t010234002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t010234002.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t010234002.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	PANTHER
NV2t010234002.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	InterPro
NV2t010234002.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t010234002.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t010234002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t010234002.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t010234003.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	PANTHER
NV2t010234003.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	InterPro
NV2t010235001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010236001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t010236002.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t010241001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010241001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t010241001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t010241001.1	molecular_function	GO:0022832	voltage-gated channel activity	"Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010241001.1	molecular_function	GO:0097682	intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity	"Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts." [GOC:ha, PMID:24375408]	PANTHER
NV2t010243001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t010243001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010243002.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t010243002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010243002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010244001.1	molecular_function	GO:0090729	toxin activity	"Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom." [GOC:pt]	InterPro
NV2t010245001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t010245001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t010247001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t010247001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t010248001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t010248001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t010250001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t010250001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t010250001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t010250001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t010250001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t010250001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010250001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010251001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010251001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t010251001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010252001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t010254001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t010254001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t010254001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t010254001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t010254001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t010254001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t010254001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t010254001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t010254001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010254001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t010258001.1	cellular_component	GO:0061617	MICOS complex	"Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]	PANTHER
NV2t010260001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010260001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010260001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010261001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t010261001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t010261001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t010261001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t010262001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010262001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010262001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t010262001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t010262001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t010262001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t010262001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010262002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010262002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010262002.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t010262002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010262003.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010262003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010262003.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t010262003.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010263001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010263001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010263001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t010263001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t010263001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t010263001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t010263001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010263002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010263002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010263002.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t010263002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010263003.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010263003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010263003.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t010263003.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010263004.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010263004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010263004.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t010263004.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010264001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t010264001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t010265001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010266001.1	biological_process	GO:0060828	regulation of canonical Wnt signaling pathway	"Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]	InterPro
NV2t010266001.1	biological_process	GO:0060828	regulation of canonical Wnt signaling pathway	"Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]	OMA
NV2t010267001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010267001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010267001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010268001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010269001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t010269001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010272001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010272001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t010272001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t010272001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t010272001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t010272001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t010273002.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273003.1	biological_process	GO:0002183	cytoplasmic translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]	OMA
NV2t010273003.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t010273003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010273003.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t010273003.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t010273003.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t010273003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t010273003.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t010273003.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273004.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273005.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273006.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273007.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273008.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273009.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273010.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273011.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273012.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273014.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273015.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273016.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273017.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273018.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010273019.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t010275001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t010275002.1	biological_process	GO:0006851	mitochondrial calcium ion transmembrane transport	"The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai]	OMA
NV2t010275002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t010275002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t010276001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t010276001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010276001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t010276001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	PANTHER
NV2t010276002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010276002.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t010276002.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	PANTHER
NV2t010276003.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t010276003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010276003.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t010276003.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	PANTHER
NV2t010277001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t010277001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010277001.1	cellular_component	GO:0034998	oligosaccharyltransferase I complex	"An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes." [PMID:15835887]	InterPro
NV2t010277001.1	cellular_component	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t010277001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t010277001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t010277001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t010278001.1	cellular_component	GO:0034709	methylosome	"A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452]	PANTHER
NV2t010278001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010278002.1	biological_process	GO:0007309	oocyte axis specification	"The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]	OMA
NV2t010278002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010278002.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t010278002.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t010278002.1	cellular_component	GO:0034709	methylosome	"A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452]	PANTHER
NV2t010278002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010278002.1	molecular_function	GO:0008327	methyl-CpG binding	"Binding to a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232]	OMA
NV2t010278002.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t010278003.1	cellular_component	GO:0034709	methylosome	"A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452]	PANTHER
NV2t010278003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010283001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	InterPro
NV2t010283001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t010283001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t010284001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t010284002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t010284002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t010284003.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t010284003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t010284004.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t010284004.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t010284005.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t010284005.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t010284006.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t010284006.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t010288001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t010288001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t010288001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010288001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010289001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010289001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010289001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	InterPro
NV2t010289001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t010293001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010295001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t010295001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t010295001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t010295001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t010295001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t010295001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t010295001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t010295001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t010295001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010295001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t010297001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010297001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010298001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010298001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010298001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010298001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010304001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010304001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010304001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010305001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t010305001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t010305001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	OMA
NV2t010305001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010305001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010306001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t010306001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t010306001.1	biological_process	GO:0006575	cellular modified amino acid metabolic process	"The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t010306001.1	biological_process	GO:0018958	phenol-containing compound metabolic process	"The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732]	OMA
NV2t010306001.1	biological_process	GO:0042445	hormone metabolic process	"The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t010306001.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t010306001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t010306001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t010306001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t010306001.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	OMA
NV2t010306001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	OMA
NV2t010306001.1	molecular_function	GO:0070573	metallodipeptidase activity	"Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t010307001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010307001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010307001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010307001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010308001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010308001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t010308001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t010308001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t010308001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t010315001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t010316001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t010316001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t010316001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t010316001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t010316001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t010316001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t010316001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t010316001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t010316001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010318001.1	biological_process	GO:0046328	regulation of JNK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	InterPro
NV2t010318001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010321001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010322001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t010322001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010323001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010323001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t010323001.1	molecular_function	GO:0004708	MAP kinase kinase activity	"Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684]	OMA
NV2t010323001.1	molecular_function	GO:0004708	MAP kinase kinase activity	"Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684]	PANTHER
NV2t010323001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010323001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010323001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010324001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010324001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010326001.1	biological_process	GO:0006538	glutamate catabolic process	"The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	PANTHER
NV2t010326001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010326001.1	molecular_function	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]	InterPro
NV2t010330001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010330001.1	molecular_function	GO:0061665	SUMO ligase activity	"Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]	PANTHER
NV2t010336001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010336001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010348001.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348001.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348002.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348002.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	OMA
NV2t010348002.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348002.1	molecular_function	GO:0003810	protein-glutamine gamma-glutamyltransferase activity	"Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13]	OMA
NV2t010348003.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348003.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348004.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348004.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348005.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348005.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348006.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348006.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348007.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348007.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348008.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348008.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348009.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348009.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348010.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	InterPro
NV2t010348010.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010348011.1	biological_process	GO:0018149	peptide cross-linking	"The formation of a covalent cross-link between or within protein chains." [GOC:jsg]	PANTHER
NV2t010351001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010352001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010352002.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t010352003.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t010352004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010352005.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t010352006.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t010352007.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t010353001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010353001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010355001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010355001.1	biological_process	GO:2000036	regulation of stem cell population maintenance	"Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol]	PANTHER
NV2t010356001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t010356001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t010357001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t010363001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t010364001.1	biological_process	GO:0007130	synaptonemal complex assembly	"The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]	InterPro
NV2t010364001.1	biological_process	GO:0007130	synaptonemal complex assembly	"The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]	OMA
NV2t010364001.1	biological_process	GO:0051878	lateral element assembly	"The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847]	PANTHER
NV2t010364001.1	cellular_component	GO:0000795	synaptonemal complex	"A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh]	OMA
NV2t010365001.1	biological_process	GO:0048205	COPI coating of Golgi vesicle	"The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t010365001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t010365001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t010365003.1	biological_process	GO:0048205	COPI coating of Golgi vesicle	"The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t010365003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t010368001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t010368001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t010368001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t010368001.1	cellular_component	GO:0043240	Fanconi anaemia nuclear complex	"A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]	PANTHER
NV2t010368001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t010370001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010371001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010374001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010374001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t010374001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t010374001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t010374001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010374001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t010375001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010375001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t010375001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t010375001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t010375001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010375001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010375001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010375001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t010376001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	PANTHER
NV2t010376001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t010378001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t010378001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t010378001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	InterPro
NV2t010378001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	OMA
NV2t010382001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010382001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010382002.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010382002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010384001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	InterPro
NV2t010384001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t010385001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010386001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t010387001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010388001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010388002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010390001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t010391001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010393001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t010393001.1	biological_process	GO:0007000	nucleolus organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]	OMA
NV2t010393001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t010393001.1	biological_process	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t010393001.1	biological_process	GO:0043486	obsolete histone exchange	"OBSOLETE. The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]	PANTHER
NV2t010393001.1	cellular_component	GO:0000118	histone deacetylase complex	"A protein complex that possesses histone deacetylase activity." [GOC:mah]	OMA
NV2t010393001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t010393001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t010393001.1	cellular_component	GO:0097346	INO80-type complex	"A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820]	OMA
NV2t010393001.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	OMA
NV2t010393002.1	biological_process	GO:0043486	obsolete histone exchange	"OBSOLETE. The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]	PANTHER
NV2t010393003.1	biological_process	GO:0043486	obsolete histone exchange	"OBSOLETE. The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]	PANTHER
NV2t010395001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010395001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010395001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010395002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010396001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010396001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010396001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010397002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010397002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010398001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010398002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010398002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010405001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010405001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010405001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010405001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010407001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010408001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t010408001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t010409001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t010409001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t010409001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t010409001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t010409001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t010410001.1	biological_process	GO:0006812	monoatomic cation transport	"The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t010410001.1	biological_process	GO:0015672	inorganic cation transmembrane transport	"A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t010410001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t010410001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t010412001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010412001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t010412001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t010412001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t010412001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010412001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010415001.1	biological_process	GO:0006812	monoatomic cation transport	"The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t010415001.1	biological_process	GO:0015672	inorganic cation transmembrane transport	"A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t010415001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t010415001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t010417001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010417001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010417001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010417001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t010420001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t010420001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010420001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t010420001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t010424001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010424001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010427001.1	biological_process	GO:0006812	monoatomic cation transport	"The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t010427001.1	biological_process	GO:0015672	inorganic cation transmembrane transport	"A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t010427001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t010427001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t010429001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010429001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t010429001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t010429001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t010429001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010429001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010429001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010433001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t010433001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010433002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t010433002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010433003.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t010433003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010433004.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t010433004.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010433005.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	PANTHER
NV2t010433005.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010435001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t010435001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t010436001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t010437001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t010437001.1	biological_process	GO:0090110	COPII-coated vesicle cargo loading	"The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]	PANTHER
NV2t010437001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010437002.1	biological_process	GO:0090110	COPII-coated vesicle cargo loading	"The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]	PANTHER
NV2t010437002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010438001.1	biological_process	GO:0007281	germ cell development	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]	InterPro
NV2t010438001.1	biological_process	GO:0007281	germ cell development	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]	OMA
NV2t010439001.1	biological_process	GO:0090110	COPII-coated vesicle cargo loading	"The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]	PANTHER
NV2t010440001.1	biological_process	GO:0007281	germ cell development	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]	InterPro
NV2t010440001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010440002.1	biological_process	GO:0007281	germ cell development	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]	InterPro
NV2t010440002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010440003.1	biological_process	GO:0007281	germ cell development	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]	InterPro
NV2t010440003.1	biological_process	GO:0007281	germ cell development	"The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]	OMA
NV2t010440003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010441001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t010441001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t010441001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010441001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010441001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t010441001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t010442001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t010442001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t010442001.1	biological_process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t010443001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010443001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010443001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010444001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t010444001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t010444001.1	cellular_component	GO:0031080	nuclear pore outer ring	"A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t010444001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010445001.1	biological_process	GO:0045820	negative regulation of glycolytic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators]	PANTHER
NV2t010445001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t010448001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t010448001.1	cellular_component	GO:0031080	nuclear pore outer ring	"A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t010448001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010448002.1	cellular_component	GO:0031080	nuclear pore outer ring	"A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t010448002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010448003.1	cellular_component	GO:0031080	nuclear pore outer ring	"A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t010448003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010449001.1	biological_process	GO:0045820	negative regulation of glycolytic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators]	PANTHER
NV2t010450001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t010456001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010457001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010457001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t010457001.1	molecular_function	GO:0047493	ceramide cholinephosphotransferase activity	"Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin." [EC:2.7.8.3, RHEA:16273]	PANTHER
NV2t010461001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010461001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	PANTHER
NV2t010462001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010462001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010462001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t010474001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t010474001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t010474001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t010475001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t010475001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t010475001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t010475001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t010475001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t010476001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t010477001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010477001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010477001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t010481001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010483001.1	biological_process	GO:0051705	obsolete multi-organism behavior	"OBSOLETE. Any process in which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai]	PANTHER
NV2t010483001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010484001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010484001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	InterPro
NV2t010485001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010485001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010485001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010485002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010485002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010485003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010485003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010485004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010485004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010485005.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010485005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010497001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010497001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010497001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010499001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010499001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t010499001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t010499001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t010502001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010502001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t010502001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010502001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t010505001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010505002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010505003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010505004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010505005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010507001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010507001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010507001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010507002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010507002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010507002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010507003.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010507003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010507003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010507003.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t010507003.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t010507003.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t010507003.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t010507003.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t010507003.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010507004.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010507004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010507004.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010507005.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010507005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010507005.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010507006.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010507006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010507006.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010509001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t010512001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010512001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t010512001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	InterPro
NV2t010512001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t010512001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t010512001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t010512001.1	molecular_function	GO:0016835	carbon-oxygen lyase activity	"Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]	OMA
NV2t010512001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t010512001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t010514001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010514001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t010514001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t010514001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t010514001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t010514001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t010514001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t010514001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t010514001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t010515001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010516001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010516001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010516001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010516001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010521001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010521001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010521001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010521002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010521002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010521003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010521003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010521004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010521004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010523001.1	biological_process	GO:0006940	regulation of smooth muscle contraction	"Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]	OMA
NV2t010523001.1	biological_process	GO:0018021	peptidyl-histidine methylation	"The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317]	OMA
NV2t010523001.1	biological_process	GO:0018022	peptidyl-lysine methylation	"The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]	OMA
NV2t010523001.1	biological_process	GO:0018026	peptidyl-lysine monomethylation	"The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]	PANTHER
NV2t010523001.1	biological_process	GO:0030047	actin modification	"Covalent modification of an actin molecule." [GOC:mah]	InterPro
NV2t010523001.1	biological_process	GO:0030047	actin modification	"Covalent modification of an actin molecule." [GOC:mah]	OMA
NV2t010523001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010523001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010523001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t010523001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t010523001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010523001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t010523001.1	molecular_function	GO:0018064	protein-L-histidine N-tele-methyltransferase activity	"Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine." [RHEA:19369]	OMA
NV2t010523001.1	molecular_function	GO:0042800	histone H3K4 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein." [PMID:12086618]	OMA
NV2t010523001.1	molecular_function	GO:0046975	histone H3K36 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein." [GOC:ai]	OMA
NV2t010523002.1	biological_process	GO:0018026	peptidyl-lysine monomethylation	"The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]	PANTHER
NV2t010523002.1	biological_process	GO:0030047	actin modification	"Covalent modification of an actin molecule." [GOC:mah]	InterPro
NV2t010523002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010523003.1	biological_process	GO:0018026	peptidyl-lysine monomethylation	"The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]	PANTHER
NV2t010523003.1	biological_process	GO:0030047	actin modification	"Covalent modification of an actin molecule." [GOC:mah]	InterPro
NV2t010523003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010529001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010529001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010529001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010529001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010529002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010529002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010530001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010541001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010541001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010542001.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	PANTHER
NV2t010543001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t010543001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t010543001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t010544001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	PANTHER
NV2t010544002.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	PANTHER
NV2t010544003.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	PANTHER
NV2t010544004.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	PANTHER
NV2t010544005.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	PANTHER
NV2t010544006.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	PANTHER
NV2t010546001.1	biological_process	GO:0051764	actin crosslink formation	"The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai]	PANTHER
NV2t010546001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010546002.1	biological_process	GO:0051764	actin crosslink formation	"The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai]	PANTHER
NV2t010546002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010546003.1	biological_process	GO:0051764	actin crosslink formation	"The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai]	PANTHER
NV2t010546003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010546003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t010547001.1	biological_process	GO:0010508	positive regulation of autophagy	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t010547001.1	biological_process	GO:0031333	negative regulation of protein-containing complex assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t010547001.1	biological_process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t010547001.1	biological_process	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t010547001.1	biological_process	GO:0070861	regulation of protein exit from endoplasmic reticulum	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010547001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t010547001.1	biological_process	GO:0090317	negative regulation of intracellular protein transport	"Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t010547001.1	biological_process	GO:1904240	negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly	"Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876]	PANTHER
NV2t010547001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010548001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t010548001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t010548001.1	molecular_function	GO:0004767	sphingomyelin phosphodiesterase activity	"Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+." [EC:3.1.4.12, RHEA:19253]	InterPro
NV2t010548001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t010549001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010549001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010549001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t010549001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t010549001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t010549002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010549002.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010549003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010549003.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010550001.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t010550001.1	biological_process	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	OMA
NV2t010550001.1	biological_process	GO:0045931	positive regulation of mitotic cell cycle	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t010550001.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	InterPro
NV2t010550001.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t010550001.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	PANTHER
NV2t010550001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010550001.1	molecular_function	GO:0008190	eukaryotic initiation factor 4E binding	"Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732]	OMA
NV2t010550001.1	molecular_function	GO:0030371	translation repressor activity	"Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt]	OMA
NV2t010550002.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	InterPro
NV2t010550002.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	PANTHER
NV2t010550003.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	InterPro
NV2t010550004.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	InterPro
NV2t010550005.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	InterPro
NV2t010550005.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	PANTHER
NV2t010553001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010554001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010554001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010555001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010555001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010559001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t010560001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t010562001.1	biological_process	GO:0051292	nuclear pore complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah]	OMA
NV2t010562001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	InterPro
NV2t010562001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t010562001.1	cellular_component	GO:0034399	nuclear periphery	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]	OMA
NV2t010562001.1	cellular_component	GO:0044611	nuclear pore inner ring	"A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t010562001.1	cellular_component	GO:0044611	nuclear pore inner ring	"A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t010562001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t010563001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010563002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010563002.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t010563003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010563003.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t010563004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010563004.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t010563005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010563005.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t010563006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010563006.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t010564001.1	biological_process	GO:0001676	long-chain fatty acid metabolic process	"The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ajp]	OMA
NV2t010564001.1	biological_process	GO:0006575	cellular modified amino acid metabolic process	"The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t010564001.1	biological_process	GO:0019217	regulation of fatty acid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]	OMA
NV2t010564001.1	biological_process	GO:0031329	regulation of cellular catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t010564001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t010564001.1	biological_process	GO:0034641	obsolete cellular nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah]	OMA
NV2t010564001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t010564001.1	biological_process	GO:0050994	regulation of lipid catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]	OMA
NV2t010564001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t010564001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t010564001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t010564001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010564002.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010564003.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010564004.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010564005.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010567001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t010567002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t010567003.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t010568001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t010568002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t010568003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t010569001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t010569001.1	biological_process	GO:0008306	associative learning	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]	OMA
NV2t010569001.1	biological_process	GO:0009416	response to light stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]	OMA
NV2t010569001.1	biological_process	GO:0042391	regulation of membrane potential	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]	OMA
NV2t010569001.1	biological_process	GO:0045471	response to ethanol	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]	OMA
NV2t010569001.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	OMA
NV2t010569001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010569001.1	cellular_component	GO:0017146	NMDA selective glutamate receptor complex	"An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]	OMA
NV2t010569001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t010569001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t010569001.1	molecular_function	GO:0004972	NMDA glutamate receptor activity	"An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages." [GOC:mah, PMID:10049997]	OMA
NV2t010569001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t010569001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t010569002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010569002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t010569002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t010573001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t010573001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t010573001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t010573001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010573001.1	molecular_function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis]	OMA
NV2t010573002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t010574001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010575001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010575002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010575003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010575003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010575003.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010575004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010575005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010575006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010575007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010577001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010577001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010577001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t010579001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t010579001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t010579001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t010579001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t010579001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t010581001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t010581001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010581001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010581002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t010581002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010581002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010581003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t010581003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010581003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010581004.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t010581004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010581004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010581005.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t010581005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010581005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010581005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t010581006.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t010581006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010581006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010581007.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t010581007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010581007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010581008.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t010581008.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010581008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010582001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010582001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010582001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010584001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010584001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010586001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010586001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010586001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010586001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t010587001.1	biological_process	GO:0032933	SREBP signaling pathway	"The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871]	PANTHER
NV2t010587001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t010588001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010588001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t010588001.1	molecular_function	GO:0004683	calmodulin-dependent protein kinase activity	"Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah, PMID:11264466]	OMA
NV2t010588001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t010588001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010588001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010591001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010591001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t010591001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	InterPro
NV2t010591001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t010591001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t010591001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t010591001.1	molecular_function	GO:0016835	carbon-oxygen lyase activity	"Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]	OMA
NV2t010591001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t010591001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t010592001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t010592001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t010592001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t010592001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t010592001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t010594001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t010596001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t010596001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t010596001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t010596001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t010596001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t010596001.1	biological_process	GO:0044806	G-quadruplex DNA unwinding	"The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'." [GOC:jl, GOC:se, PMID:23657261]	PANTHER
NV2t010596001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010596001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010596001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010596001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010596001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	InterPro
NV2t010596001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	OMA
NV2t010597001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010597001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010599001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010599001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t010599001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010600001.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t010600001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010601001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t010601001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t010604001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t010607001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t010607001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010607001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010607001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010607001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010614001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t010615001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010615001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010616001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t010616001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t010616001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	InterPro
NV2t010616001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t010616001.1	molecular_function	GO:0140103	catalytic activity, acting on a glycoprotein	"Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t010618001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t010618001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t010618002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t010618003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t010619001.1	molecular_function	GO:0004104	cholinesterase activity	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]	InterPro
NV2t010619001.1	molecular_function	GO:0004104	cholinesterase activity	"Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]	OMA
NV2t010620001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010620001.1	biological_process	GO:0006013	mannose metabolic process	"The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]	InterPro
NV2t010620001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t010620001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t010620001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t010620001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t010620001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t010620001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t010620001.1	molecular_function	GO:0004559	alpha-mannosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]	OMA
NV2t010620001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t010620001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t010621001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t010621001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010621001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010621001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010621001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010623001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010624001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010624001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010624001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010626001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t010626002.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t010626002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t010626002.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t010626002.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t010626002.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t010627001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010627002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010627002.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t010627002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010627002.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	OMA
NV2t010627003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010627004.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010627005.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010627006.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010627006.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t010627006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010628001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010628001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010628001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t010628001.1	cellular_component	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	PANTHER
NV2t010628002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010628002.1	cellular_component	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	PANTHER
NV2t010629001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	InterPro
NV2t010635001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t010635001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010636001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010636002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010640001.1	biological_process	GO:0006788	heme oxidation	"The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah]	InterPro
NV2t010640001.1	biological_process	GO:0055072	obsolete iron ion homeostasis	"OBSOLETE. Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	PANTHER
NV2t010641001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t010641001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t010642001.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t010642001.1	biological_process	GO:0035999	tetrahydrofolate interconversion	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999]	PANTHER
NV2t010642001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t010642001.1	biological_process	GO:0042559	pteridine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]	OMA
NV2t010642001.1	biological_process	GO:0046653	tetrahydrofolate metabolic process	"The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	OMA
NV2t010642001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t010642001.1	molecular_function	GO:0016882	cyclo-ligase activity	"Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	OMA
NV2t010643001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010643001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010643001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010643001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t010647001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010647001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010647001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t010647001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t010648001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t010648001.1	molecular_function	GO:1990050	phosphatidic acid transfer activity	"Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]	OMA
NV2t010648001.1	molecular_function	GO:1990050	phosphatidic acid transfer activity	"Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293]	PANTHER
NV2t010650001.1	biological_process	GO:0003143	embryonic heart tube morphogenesis	"The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]	OMA
NV2t010650001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t010650001.1	biological_process	GO:0060026	convergent extension	"The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:dgf, GOC:dph, PMID:12062082]	OMA
NV2t010650001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t010650001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t010650001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	InterPro
NV2t010650001.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	OMA
NV2t010650001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010654001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010654001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010654001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010656001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t010656001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t010656001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t010656001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t010656001.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	OMA
NV2t010656001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t010663001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t010663001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t010663001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t010663001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t010663001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t010663001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010663001.1	cellular_component	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t010663001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t010663001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t010663001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010663002.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t010663002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t010663002.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010666001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t010667001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t010667001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t010667001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t010667001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t010667001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t010667001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	OMA
NV2t010667001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t010667001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t010667001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t010667001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010667001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t010667001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t010667001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t010667001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t010668001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010669001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010669001.1	biological_process	GO:1902749	regulation of cell cycle G2/M phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	PANTHER
NV2t010669002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010669002.1	biological_process	GO:1902749	regulation of cell cycle G2/M phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	PANTHER
NV2t010669003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010669003.1	biological_process	GO:1902749	regulation of cell cycle G2/M phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	PANTHER
NV2t010669004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010669004.1	biological_process	GO:1902749	regulation of cell cycle G2/M phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	PANTHER
NV2t010669005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010669005.1	biological_process	GO:1902749	regulation of cell cycle G2/M phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	PANTHER
NV2t010669006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010669006.1	biological_process	GO:1902749	regulation of cell cycle G2/M phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	PANTHER
NV2t010670001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t010670001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010670001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t010670002.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t010675001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t010675001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t010675001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t010675001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t010675001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t010675001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t010675001.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t010675001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t010675001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t010675001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t010678001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t010678001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t010678001.1	cellular_component	GO:0005575	cellular_component	"A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex)." [GOC:pdt]	OMA
NV2t010678001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	InterPro
NV2t010678001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	OMA
NV2t010680001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010680001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t010680001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t010680001.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t010680001.1	cellular_component	GO:0032153	cell division site	"The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]	OMA
NV2t010680001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t010680001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010680002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010680002.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t010681001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010681001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010681002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010681002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010681002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010681002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t010684001.1	cellular_component	GO:0016514	SWI/SNF complex	"A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof." [GOC:bhm, PMID:12672490]	PANTHER
NV2t010687001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	OMA
NV2t010687001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	PANTHER
NV2t010688001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t010688001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010688001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t010688001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t010688001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010688001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t010689001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t010689001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	OMA
NV2t010689001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t010690001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t010690002.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t010690003.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t010690004.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t010691001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010691002.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t010691002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010691002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010691003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010691004.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t010691004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010691005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010691006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010691007.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010694001.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	PANTHER
NV2t010695001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	PANTHER
NV2t010696001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010696001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010696001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010696002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010696002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010696002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010696002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010696002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010696002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t010696003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010696003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010696003.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010696004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010696004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010696004.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010697001.1	biological_process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	PANTHER
NV2t010697001.1	cellular_component	GO:0008537	proteasome activator complex	"A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb]	InterPro
NV2t010697001.1	cellular_component	GO:0022624	proteasome accessory complex	"A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]	OMA
NV2t010698001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010698001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010698002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010700001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t010702001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t010702001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010702001.1	molecular_function	GO:0016907	G protein-coupled acetylcholine receptor activity	"Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]	OMA
NV2t010706001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t010706001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010706001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t010706001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010706001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t010708001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010708001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t010713001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010714001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t010714001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t010714001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t010714001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t010716001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010716001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010717001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t010717001.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	OMA
NV2t010717001.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	OMA
NV2t010717001.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t010717001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010717001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t010717001.1	cellular_component	GO:0032432	actin filament bundle	"An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]	OMA
NV2t010717001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010717001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010717001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t010718001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	OMA
NV2t010718001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010718001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010718001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t010718001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t010718002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010718002.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t010718004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010718004.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t010722001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t010722001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t010722001.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	OMA
NV2t010722001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t010722001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010722001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010722001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t010722001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t010722001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010722001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t010722001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t010722001.1	molecular_function	GO:0048027	mRNA 5'-UTR binding	"Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]	OMA
NV2t010722001.1	molecular_function	GO:1990247	N6-methyladenosine-containing RNA reader activity	"A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]	OMA
NV2t010725001.1	biological_process	GO:0006623	protein targeting to vacuole	"The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t010725001.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	OMA
NV2t010725001.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t010725001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t010725001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t010725001.1	cellular_component	GO:0030897	HOPS complex	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]	OMA
NV2t010725001.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	OMA
NV2t010725001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010727001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t010727001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010727002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010727003.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t010727003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t010727005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t010728001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010728001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010728001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010728001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t010728001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t010728001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t010728001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010729001.1	biological_process	GO:0018022	peptidyl-lysine methylation	"The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]	OMA
NV2t010729001.1	molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]	OMA
NV2t010730001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t010730001.1	molecular_function	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]	OMA
NV2t010730002.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t010731001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010731001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010732001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t010733001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010737001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t010737001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t010744001.1	biological_process	GO:0009072	aromatic amino acid metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	InterPro
NV2t010744001.1	biological_process	GO:1902000	homogentisate catabolic process	"The chemical reactions and pathways resulting in the breakdown of homogentisate." [GOC:TermGenie, PMID:22980205]	PANTHER
NV2t010744001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t010745001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t010745001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	OMA
NV2t010745001.1	molecular_function	GO:0004826	phenylalanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]	OMA
NV2t010745001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010746001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t010746001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010746001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t010746001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t010746001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	InterPro
NV2t010746001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t010746001.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	OMA
NV2t010746001.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	PANTHER
NV2t010747001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010747001.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t010747002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010747002.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t010747003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010747003.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t010747004.1	biological_process	GO:0006882	intracellular zinc ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t010747004.1	biological_process	GO:0010043	response to zinc ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]	OMA
NV2t010747004.1	biological_process	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t010747004.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t010747004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010747004.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t010747004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010747004.1	molecular_function	GO:0005385	zinc ion transmembrane transporter activity	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t010748001.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	PANTHER
NV2t010748001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010749001.1	biological_process	GO:0042572	retinol metabolic process	"The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]	OMA
NV2t010749001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010749001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t010751001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t010751001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010752001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t010752001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010752001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t010752001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t010752001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t010752001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t010752001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010752001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010753001.1	biological_process	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	OMA
NV2t010753001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t010753001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t010753001.1	biological_process	GO:0055072	obsolete iron ion homeostasis	"OBSOLETE. Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	OMA
NV2t010753001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t010753001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t010753001.1	molecular_function	GO:0005375	copper ion transmembrane transporter activity	"Enables the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t010753001.1	molecular_function	GO:0005381	iron ion transmembrane transporter activity	"Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t010753001.1	molecular_function	GO:0005384	manganese ion transmembrane transporter activity	"Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t010753001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t010753001.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	InterPro
NV2t010753002.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	InterPro
NV2t010753003.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	InterPro
NV2t010753004.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	InterPro
NV2t010754001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t010754001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t010757001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010757001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	InterPro
NV2t010758001.1	biological_process	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	OMA
NV2t010758001.1	biological_process	GO:0035304	regulation of protein dephosphorylation	"Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	OMA
NV2t010758001.1	biological_process	GO:0035306	positive regulation of dephosphorylation	"Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]	OMA
NV2t010758001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010758001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t010759001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t010759001.1	biological_process	GO:0008154	actin polymerization or depolymerization	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t010759001.1	biological_process	GO:0051014	actin filament severing	"The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]	OMA
NV2t010759001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	OMA
NV2t010759001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t010759001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010759001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t010759001.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t010759001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t010759001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t010759002.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t010759002.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t010759002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t010760001.1	biological_process	GO:0001708	cell fate specification	"The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate." [GOC:go_curators]	OMA
NV2t010760001.1	biological_process	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t010760001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t010760001.1	biological_process	GO:0003143	embryonic heart tube morphogenesis	"The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]	OMA
NV2t010760001.1	biological_process	GO:0006029	proteoglycan metabolic process	"The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]	OMA
NV2t010760001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010760001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t010760001.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	InterPro
NV2t010760001.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	OMA
NV2t010760001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t010760001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t010760001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t010760001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t010760001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t010760001.1	biological_process	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t010760001.1	biological_process	GO:0010720	positive regulation of cell development	"Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t010760001.1	biological_process	GO:0010721	negative regulation of cell development	"Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t010760001.1	biological_process	GO:0016539	intein-mediated protein splicing	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]	InterPro
NV2t010760001.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t010760001.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	OMA
NV2t010760001.1	biological_process	GO:0022408	negative regulation of cell-cell adhesion	"Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t010760001.1	biological_process	GO:0022409	positive regulation of cell-cell adhesion	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t010760001.1	biological_process	GO:0031325	positive regulation of cellular metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t010760001.1	biological_process	GO:0035107	appendage morphogenesis	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]	OMA
NV2t010760001.1	biological_process	GO:0040008	regulation of growth	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]	OMA
NV2t010760001.1	biological_process	GO:0045880	positive regulation of smoothened signaling pathway	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t010760001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t010760001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t010760001.1	biological_process	GO:0061448	connective tissue development	"The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF]	OMA
NV2t010760001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t010760001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t010760001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010760001.1	molecular_function	GO:0005113	patched binding	"Binding to a patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473]	OMA
NV2t010760001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010760001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	OMA
NV2t010760001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t010760001.1	molecular_function	GO:0071813	lipoprotein particle binding	"Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:BHF, GOC:mah]	OMA
NV2t010760002.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	InterPro
NV2t010760002.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t010760002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t010760002.1	biological_process	GO:0016539	intein-mediated protein splicing	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]	InterPro
NV2t010760002.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t010761001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010761001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010763001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t010763001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t010763001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	InterPro
NV2t010763001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t010763001.1	biological_process	GO:0010212	response to ionizing radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]	OMA
NV2t010763001.1	biological_process	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	OMA
NV2t010763001.1	biological_process	GO:0016444	somatic cell DNA recombination	"Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]	OMA
NV2t010763001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t010763001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t010763001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t010763001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t010763001.1	cellular_component	GO:1990391	DNA repair complex	"A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]	OMA
NV2t010763001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t010763001.1	molecular_function	GO:0045027	DNA end binding	"Binding to DNA ends exposed by the creation of double-strand breaks (DSBs)." [GOC:jl]	PANTHER
NV2t010763001.1	molecular_function	GO:0070182	DNA polymerase binding	"Binding to a DNA polymerase." [GOC:BHF, GOC:mah]	OMA
NV2t010764001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010767001.1	biological_process	GO:0030514	negative regulation of BMP signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]	PANTHER
NV2t010767001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t010767001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t010767001.1	biological_process	GO:0050890	cognition	"The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908]	OMA
NV2t010767001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010767001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t010768001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t010768001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t010768001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t010768001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t010768001.1	biological_process	GO:0048489	synaptic vesicle transport	"The directed movement of synaptic vesicles." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr]	OMA
NV2t010768001.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	InterPro
NV2t010768001.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	OMA
NV2t010768001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t010768001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t010769001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010769001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t010771001.1	cellular_component	GO:0140284	endoplasmic reticulum-endosome membrane contact site	"A contact site between the endoplasmic reticulum membrane and the endosome membrane." [PMID:24105263, PMID:30220460]	PANTHER
NV2t010771001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t010771001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t010772001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t010772001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010775001.1	biological_process	GO:0010951	negative regulation of endopeptidase activity	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t010775001.1	biological_process	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	OMA
NV2t010775001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t010775001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t010775001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t010775001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t010775001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t010775001.1	biological_process	GO:0071695	anatomical structure maturation	"A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]	OMA
NV2t010775001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t010775001.1	biological_process	GO:0090210	regulation of establishment of blood-brain barrier	"Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb]	OMA
NV2t010775001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	OMA
NV2t010775001.1	biological_process	GO:1904683	regulation of metalloendopeptidase activity	"Any process that modulates the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]	OMA
NV2t010775001.1	biological_process	GO:1904684	negative regulation of metalloendopeptidase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254]	PANTHER
NV2t010775001.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t010775001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010775001.1	cellular_component	GO:1990909	Wnt signalosome	"A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]	OMA
NV2t010775001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010775001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t010775001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	OMA
NV2t010775001.1	molecular_function	GO:0015026	coreceptor activity	"Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]	OMA
NV2t010777001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010777001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010777001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t010777001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t010780001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	InterPro
NV2t010780001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t010780001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t010781001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t010781001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t010781001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010782001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010782001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010784001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t010784001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t010784001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010784001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010784001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t010784001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t010784001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t010785001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t010785001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t010785001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	InterPro
NV2t010785001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t010786001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t010786001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	PANTHER
NV2t010786001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010787001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010787002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010788001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t010788001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t010788001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t010788001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t010789001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010789001.1	biological_process	GO:0030832	regulation of actin filament length	"Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah]	PANTHER
NV2t010789001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t010789001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010789001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010789002.1	biological_process	GO:0030832	regulation of actin filament length	"Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah]	PANTHER
NV2t010789002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t010789002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t010789002.1	molecular_function	GO:0003774	cytoskeletal motor activity	"Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]	OMA
NV2t010789002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010789002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010789003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010789003.1	biological_process	GO:0030832	regulation of actin filament length	"Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah]	PANTHER
NV2t010789003.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t010789003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010790001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010793001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t010793001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t010793001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t010793001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010794001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t010794001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t010796001.1	biological_process	GO:0019853	L-ascorbic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:ma, ISBN:0198547684]	PANTHER
NV2t010796001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010796001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	InterPro
NV2t010796001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t010796001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t010797001.1	cellular_component	GO:0044545	NSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]	PANTHER
NV2t010798001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t010798001.1	biological_process	GO:0032008	positive regulation of TOR signaling	"Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t010798001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010798001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t010798001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t010798001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t010798001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t010798001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t010798001.1	molecular_function	GO:0098772	molecular function regulator activity	"A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt]	OMA
NV2t010799001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t010799001.1	biological_process	GO:0044093	positive regulation of molecular function	"Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	OMA
NV2t010799001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t010799001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t010799001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t010802001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010804001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	OMA
NV2t010804001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010804001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010804001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010804001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010804001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t010804001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t010804001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t010806001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t010809001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t010809001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010809001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t010809001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t010810001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t010810001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010810001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010810001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t010811001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t010811001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t010811001.1	biological_process	GO:0010458	exit from mitosis	"The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]	OMA
NV2t010811001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t010811001.1	biological_process	GO:0031468	nuclear membrane reassembly	"The reformation of the nuclear membranes following their breakdown in the context of a normal process." [GOC:mah]	OMA
NV2t010811001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t010811001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t010811001.1	biological_process	GO:0045324	late endosome to vacuole transport	"The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]	PANTHER
NV2t010811001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t010811001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t010811001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t010811001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t010811001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t010811002.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t010811002.1	biological_process	GO:0045324	late endosome to vacuole transport	"The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]	PANTHER
NV2t010812001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010812001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010812001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010812001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010814001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t010814001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t010814001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	InterPro
NV2t010814001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	OMA
NV2t010814001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t010814001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t010814001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t010815001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010817001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010818001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010818001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010818001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010818002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010818002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010818002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010818003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010818003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010818003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010818004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010818004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010818004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010818005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t010818005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010818005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010820001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	InterPro
NV2t010821001.1	biological_process	GO:0006218	uridine catabolic process	"The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]	PANTHER
NV2t010821001.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t010821001.1	biological_process	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	InterPro
NV2t010821001.1	biological_process	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t010821001.1	biological_process	GO:0042454	ribonucleoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl]	OMA
NV2t010821001.1	biological_process	GO:0072527	pyrimidine-containing compound metabolic process	"The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t010821001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010821001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t010821001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t010821002.1	biological_process	GO:0006218	uridine catabolic process	"The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]	PANTHER
NV2t010821002.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t010821002.1	biological_process	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	InterPro
NV2t010821003.1	biological_process	GO:0006218	uridine catabolic process	"The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]	PANTHER
NV2t010821003.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	InterPro
NV2t010821003.1	biological_process	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	InterPro
NV2t010822001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010822001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010823001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t010823001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t010823001.1	cellular_component	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	OMA
NV2t010823001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t010823001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t010824001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010824002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010824003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010824003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t010824004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t010825001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010825001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010825001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t010828001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010828001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t010830001.1	biological_process	GO:0006775	fat-soluble vitamin metabolic process	"The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]	OMA
NV2t010830001.1	biological_process	GO:0017187	peptidyl-glutamic acid carboxylation	"The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]	OMA
NV2t010830001.1	biological_process	GO:1901661	quinone metabolic process	"The chemical reactions and pathways involving quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie]	OMA
NV2t010830001.1	molecular_function	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	"Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t010830001.1	molecular_function	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	"Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues." [RHEA:57744]	InterPro
NV2t010830001.1	molecular_function	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	"Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues." [RHEA:57744]	PANTHER
NV2t010831001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010831001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010831001.1	molecular_function	GO:0005215	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	PANTHER
NV2t010831001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010833001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t010833001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t010833001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t010833001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t010833001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t010833001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t010833001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010833001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010833002.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t010833002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t010833002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t010833002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010833003.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t010833003.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t010833003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t010833003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010834001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t010834001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	OMA
NV2t010834001.1	biological_process	GO:0040001	establishment of mitotic spindle localization	"The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]	InterPro
NV2t010834001.1	biological_process	GO:0040001	establishment of mitotic spindle localization	"The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]	OMA
NV2t010834001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t010834001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t010834001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t010834001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t010834001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t010840001.1	biological_process	GO:0034755	iron ion transmembrane transport	"A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah, PMID:11390404]	InterPro
NV2t010840001.1	biological_process	GO:0055072	obsolete iron ion homeostasis	"OBSOLETE. Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	OMA
NV2t010840001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t010840001.1	molecular_function	GO:0005381	iron ion transmembrane transporter activity	"Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t010840001.1	molecular_function	GO:0017046	peptide hormone binding	"Binding to a peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732]	OMA
NV2t010841001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t010841001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t010841001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t010841001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t010841001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t010841001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t010841001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010841001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010841001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t010843001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t010844001.1	biological_process	GO:0006672	ceramide metabolic process	"The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]	OMA
NV2t010844001.1	biological_process	GO:0031327	negative regulation of cellular biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t010844001.1	biological_process	GO:0034249	negative regulation of amide metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]	OMA
NV2t010844001.1	biological_process	GO:0051055	negative regulation of lipid biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	OMA
NV2t010844001.1	biological_process	GO:0055082	intracellular chemical homeostasis	"A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." [GOC:isa_complete, GOC:jid]	OMA
NV2t010844001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t010844001.1	biological_process	GO:0090156	intracellular sphingolipid homeostasis	"A homeostatic process involved in the maintenance of a steady state level of sphingolipids within a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t010844001.1	biological_process	GO:2000303	regulation of ceramide biosynthetic process	"Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph]	OMA
NV2t010844001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010844001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010844001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t010844001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t010844002.1	biological_process	GO:0090156	intracellular sphingolipid homeostasis	"A homeostatic process involved in the maintenance of a steady state level of sphingolipids within a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t010844002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010845001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t010845001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t010845001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t010845001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t010845001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t010845001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t010845001.1	cellular_component	GO:0034464	BBSome	"A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B." [GOC:BHF, GOC:cilia, PMID:15231740, PMID:17574030, PMID:26498262]	InterPro
NV2t010845001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t010845001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t010845001.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	OMA
NV2t010845001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t010846001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t010846001.1	biological_process	GO:0043951	negative regulation of cAMP-mediated signaling	"Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling." [GOC:jl]	PANTHER
NV2t010846001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010846001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t010847001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t010847001.1	biological_process	GO:0007041	lysosomal transport	"The directed movement of substances into, out of or within a lysosome." [GOC:ai]	OMA
NV2t010847001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t010847001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t010847001.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t010847001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t010847001.1	biological_process	GO:0051036	regulation of endosome size	"Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai]	OMA
NV2t010847001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t010847001.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t010847001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010847001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t010847001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t010847001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010847001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t010847001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t010847001.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t010847001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t010847001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t010847001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t010847001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t010847001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t010847001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t010847001.1	molecular_function	GO:0043539	protein serine/threonine kinase activator activity	"Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]	OMA
NV2t010848001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t010848001.1	biological_process	GO:0036071	N-glycan fucosylation	"The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [GOC:sart, PMID:19948734]	OMA
NV2t010848001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t010848001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t010848001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t010848001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010848001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	OMA
NV2t010848001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t010848001.1	molecular_function	GO:0140103	catalytic activity, acting on a glycoprotein	"Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t010848002.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t010848002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010848002.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t010848003.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t010848003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010848003.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t010849001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t010851001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t010852001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	PANTHER
NV2t010853003.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t010853004.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t010854001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010854001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t010854002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010854002.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t010855001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	InterPro
NV2t010855001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	OMA
NV2t010855001.1	biological_process	GO:0036503	ERAD pathway	"The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]	OMA
NV2t010855001.1	biological_process	GO:0045048	protein insertion into ER membrane	"The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]	OMA
NV2t010855001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010855001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t010855001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t010855001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t010855001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t010855001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t010855002.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	InterPro
NV2t010855003.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	InterPro
NV2t010855004.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	InterPro
NV2t010855005.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	InterPro
NV2t010857001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t010857001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010857001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t010857001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t010857001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010857001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010857002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t010857002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t010857002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010859001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t010859001.1	biological_process	GO:0051307	meiotic chromosome separation	"The process in which chromosomes are physically detached from each other during meiosis." [GOC:ai]	OMA
NV2t010859001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010859001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010859001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t010859001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t010859001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t010859001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t010860001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t010860001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t010860001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010860001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t010860001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t010861001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010861001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010862001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010862001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010863001.1	biological_process	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	PANTHER
NV2t010863001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010863002.1	biological_process	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	PANTHER
NV2t010863002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010864001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010864001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010864001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t010865001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010865001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010865001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t010867001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t010867001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t010867001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t010867001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t010867001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010867001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t010871001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t010873001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010873001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t010873001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010875001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t010875001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t010875001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010876001.1	biological_process	GO:0045333	cellular respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]	OMA
NV2t010876001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t010876001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t010876001.1	molecular_function	GO:0048039	ubiquinone binding	"Binding to ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jid, ISBN:0582227089]	InterPro
NV2t010878001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t010878001.1	biological_process	GO:0045494	photoreceptor cell maintenance	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]	OMA
NV2t010878001.1	biological_process	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	InterPro
NV2t010878001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t010878001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t010878001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010879001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t010879001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t010879001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	PANTHER
NV2t010879001.1	cellular_component	GO:0005664	nuclear origin of replication recognition complex	"A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]	OMA
NV2t010879001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t010880001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t010880001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t010880001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	OMA
NV2t010880001.1	cellular_component	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	"All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056]	InterPro
NV2t010880001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t010881001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010881001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010881001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t010882001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t010882001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t010886001.1	biological_process	GO:0019933	cAMP-mediated signaling	"An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell." [GOC:signaling]	PANTHER
NV2t010887001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t010887001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010887001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t010889001.1	biological_process	GO:0006275	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	OMA
NV2t010889001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t010889001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t010889001.1	biological_process	GO:0033044	regulation of chromosome organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]	OMA
NV2t010889001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t010889001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t010889001.1	biological_process	GO:0051571	obsolete positive regulation of histone H3-K4 methylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah]	OMA
NV2t010889001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t010889001.1	biological_process	GO:1900182	positive regulation of protein localization to nucleus	"Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	OMA
NV2t010889001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t010889001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010889001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t010889001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t010889001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	OMA
NV2t010889001.1	cellular_component	GO:0044545	NSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]	OMA
NV2t010889001.1	cellular_component	GO:0044665	MLL1/2 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t010889001.1	cellular_component	GO:0071339	MLL1 complex	"A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975]	InterPro
NV2t010889001.1	molecular_function	GO:0002151	G-quadruplex RNA binding	"Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720]	OMA
NV2t010889001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010889001.1	molecular_function	GO:0008266	poly(U) RNA binding	"Binding to a sequence of uracil residues in an RNA molecule." [GOC:mah]	OMA
NV2t010889001.1	molecular_function	GO:0070717	poly-purine tract binding	"Binding to a stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah]	OMA
NV2t010891001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010893001.1	biological_process	GO:0032049	cardiolipin biosynthetic process	"The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah]	InterPro
NV2t010893001.1	biological_process	GO:0032049	cardiolipin biosynthetic process	"The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah]	OMA
NV2t010893001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t010893001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t010893001.1	molecular_function	GO:0004605	phosphatidate cytidylyltransferase activity	"Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41]	OMA
NV2t010895001.1	biological_process	GO:0030970	retrograde protein transport, ER to cytosol	"The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744]	PANTHER
NV2t010896001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010896001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010896001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t010897001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t010897001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t010897001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010897001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010897001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t010897001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t010898001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t010899001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010903001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010903001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t010903001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t010905001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t010907001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010909001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010912001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t010912001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t010913001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t010914001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010914001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010915001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t010915001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010915002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t010915002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010919001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t010919001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010919001.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	PANTHER
NV2t010923001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t010923001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010923002.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t010923002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010923003.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t010923003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010924001.1	biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]	PANTHER
NV2t010924001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t010924001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t010924002.1	biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]	PANTHER
NV2t010924002.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t010924002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t010924003.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t010924003.1	biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]	PANTHER
NV2t010924003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010924003.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	OMA
NV2t010924003.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t010924003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t010924003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t010924004.1	biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]	PANTHER
NV2t010924004.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t010924004.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t010924005.1	biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]	PANTHER
NV2t010924005.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t010924005.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t010924006.1	biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]	PANTHER
NV2t010924006.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t010924006.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t010925001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t010925001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t010925001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t010925001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t010925001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t010925001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t010925001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t010928001.1	biological_process	GO:0006878	intracellular copper ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t010928001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t010928001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t010928001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t010928001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t010928001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t010928001.1	biological_process	GO:0048753	pigment granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]	OMA
NV2t010928001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010928001.1	biological_process	GO:0070925	organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t010928001.1	biological_process	GO:0098849	cellular detoxification of cadmium ion	"Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw]	OMA
NV2t010928001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t010928001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t010928001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t010928001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t010928001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t010928001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t010928001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t010928001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010928001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t010928001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t010928001.1	cellular_component	GO:0036020	endolysosome membrane	"The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]	OMA
NV2t010928001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t010928001.1	cellular_component	GO:0090741	pigment granule membrane	"Any membrane that is part of a pigment granule." [PMID:11294610]	OMA
NV2t010928001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t010928001.1	molecular_function	GO:0015439	ABC-type heme transporter activity	"Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [RHEA:19261]	OMA
NV2t010928001.1	molecular_function	GO:0015562	efflux transmembrane transporter activity	"Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010928001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010928001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t010928001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t010928001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010928002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010928002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010928002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010928003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010928003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010928003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t010928003.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010929001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t010929001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t010929001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t010929002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t010929003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t010930001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010931001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t010931001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t010931001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t010933002.1	cellular_component	GO:0032783	super elongation complex	"A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae." [PMID:17150956, PMID:30102332]	InterPro
NV2t010940001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t010940001.1	molecular_function	GO:0004965	G protein-coupled GABA receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]	OMA
NV2t010943001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010943001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t010943001.1	molecular_function	GO:0004965	G protein-coupled GABA receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]	OMA
NV2t010946001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t010947001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t010948001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t010949001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t010949001.1	cellular_component	GO:0001669	acrosomal vesicle	"A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]	OMA
NV2t010949001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	OMA
NV2t010949001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t010949001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t010951001.1	biological_process	GO:0000245	spliceosomal complex assembly	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]	OMA
NV2t010951001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t010951001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t010951001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t010951001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t010951001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t010951001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t010954001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t010954001.1	cellular_component	GO:1902555	endoribonuclease complex	"A protein complex which is capable of endoribonuclease activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t010954001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t010954001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010954001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t010954001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	PANTHER
NV2t010957001.1	biological_process	GO:0044341	sodium-dependent phosphate transport	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]	InterPro
NV2t010957001.1	biological_process	GO:0044341	sodium-dependent phosphate transport	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]	OMA
NV2t010957001.1	cellular_component	GO:0005903	brush border	"The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]	OMA
NV2t010957001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t010957001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t010957001.1	molecular_function	GO:0005436	sodium:phosphate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [TC:2.A.1.14.6]	OMA
NV2t010958001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	PANTHER
NV2t010959001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t010959002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t010959002.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t010959003.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t010959003.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t010959003.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t010959004.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t010959004.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t010959005.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t010959005.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t010959005.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t010960001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t010960001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010960001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010960001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010960002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010961001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t010961001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t010961001.1	molecular_function	GO:0000062	fatty-acyl-CoA binding	"Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]	InterPro
NV2t010961001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t010961001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t010961001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t010961001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t010961001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t010961002.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	PANTHER
NV2t010961002.1	molecular_function	GO:0000062	fatty-acyl-CoA binding	"Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]	InterPro
NV2t010962001.1	biological_process	GO:0007130	synaptonemal complex assembly	"The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]	InterPro
NV2t010962001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	PANTHER
NV2t010962002.1	biological_process	GO:0007130	synaptonemal complex assembly	"The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]	InterPro
NV2t010962002.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	PANTHER
NV2t010963001.1	biological_process	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437]	InterPro
NV2t010965001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t010965001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t010965001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t010965001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t010965001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t010965001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010965001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t010965001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t010966001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t010966001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t010966001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t010966001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t010967001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010967002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010968001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010968001.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t010968002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010968002.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t010968003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010968003.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t010968004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010968004.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t010968005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t010968005.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t010969001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	PANTHER
NV2t010970001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t010970001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t010970001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t010972001.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t010972001.1	biological_process	GO:0019264	glycine biosynthetic process from serine	"The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators]	OMA
NV2t010972001.1	biological_process	GO:0035999	tetrahydrofolate interconversion	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999]	InterPro
NV2t010972001.1	biological_process	GO:0046653	tetrahydrofolate metabolic process	"The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	OMA
NV2t010972001.1	molecular_function	GO:0004372	glycine hydroxymethyltransferase activity	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [RHEA:15481]	OMA
NV2t010972001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t010972001.1	molecular_function	GO:0070905	serine binding	"Binding to 2-amino-3-hydroxypropanoic acid." [GOC:rph]	PANTHER
NV2t010973001.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	InterPro
NV2t010973001.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	OMA
NV2t010973001.1	cellular_component	GO:0099572	postsynaptic specialization	"A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028]	PANTHER
NV2t010974001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t010974001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t010976001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	PANTHER
NV2t010976002.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	PANTHER
NV2t010977001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010977001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010977002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t010977002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t010978001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t010978001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t010978001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	InterPro
NV2t010978001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t010978001.1	biological_process	GO:0044805	obsolete late nucleophagy	"OBSOLETE. A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM." [GOC:dgf, GOC:jl, PMID:22768199]	PANTHER
NV2t010978001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t010978001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t010978001.1	cellular_component	GO:0098852	lytic vacuole membrane	"The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]	OMA
NV2t010978001.1	molecular_function	GO:0017128	phospholipid scramblase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]	OMA
NV2t010979001.1	biological_process	GO:0007286	spermatid development	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]	OMA
NV2t010979001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t010979001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t010979001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010979001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t010979001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t010980001.1	biological_process	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	"Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]	PANTHER
NV2t010980001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t010980001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t010982001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t010982001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010982001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t010982001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t010986001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t010986001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t010986001.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t010986001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t010986001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t010986001.1	cellular_component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	"The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]	OMA
NV2t010986001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t010986001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t010987001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	PANTHER
NV2t010988001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	PANTHER
NV2t010988002.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	PANTHER
NV2t010989001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t010991001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t010991001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t010991001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t010991001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t010991001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t010991001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t010992001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t010992001.1	biological_process	GO:0031591	wybutosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]	PANTHER
NV2t010992001.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t010992001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t010992001.1	biological_process	GO:1901657	glycosyl compound metabolic process	"The chemical reactions and pathways involving glycosyl compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t010992001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t010992001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t010992001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t010992001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t010992001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t010995001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t010995001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t010995001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t010997001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t010998001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011000001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011000001.1	biological_process	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	OMA
NV2t011000001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011000001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t011000001.1	biological_process	GO:0007259	cell surface receptor signaling pathway via JAK-STAT	"A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins." [PMID:12039028]	OMA
NV2t011000001.1	biological_process	GO:0019221	cytokine-mediated signaling pathway	"The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]	OMA
NV2t011000001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	OMA
NV2t011000001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	PANTHER
NV2t011000001.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t011000001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011000001.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	OMA
NV2t011000001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t011000001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011000001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011000001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011001001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	InterPro
NV2t011001001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t011001001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t011001001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011001001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011001001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t011001001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011002001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t011002001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t011002001.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t011004001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011004002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011004003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011004004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011005001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t011005001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t011006001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011006001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011008001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011008001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011008001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011009001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t011009001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t011011001.1	biological_process	GO:0006269	DNA replication, synthesis of primer	"The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718]	InterPro
NV2t011011001.1	biological_process	GO:0006269	DNA replication, synthesis of primer	"The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718]	PANTHER
NV2t011011001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t011011001.1	cellular_component	GO:0005658	alpha DNA polymerase:primase complex	"A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377]	OMA
NV2t011011001.1	molecular_function	GO:0003896	DNA primase activity	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [GOC:mah, GOC:mcc, PMID:11395402, PMID:26184436, PMID:38203225, PMID:38492718]	OMA
NV2t011011001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011011001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t011011001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t011012001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011012001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011017001.1	biological_process	GO:1903478	obsolete actin filament bundle convergence involved in mitotic contractile ring assembly	"OBSOLETE. Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw]	PANTHER
NV2t011017001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011018001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011018001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011018002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011018002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011019001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011019001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011023001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011023001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t011025001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t011025001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011025001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011026001.1	molecular_function	GO:0016504	peptidase activator activity	"Binds to and increases the activity of a peptidase." [GOC:ai]	OMA
NV2t011026001.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	OMA
NV2t011026001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	InterPro
NV2t011026001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	OMA
NV2t011028001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011029001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011029002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011029003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011029004.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011030001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	InterPro
NV2t011030001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	PANTHER
NV2t011030006.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011032001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t011032001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t011032001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t011032001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t011032001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t011033001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t011033001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t011033001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t011033001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t011033001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t011035001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	PANTHER
NV2t011035001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011036001.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011036002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t011036002.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011036002.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t011036002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t011036002.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	OMA
NV2t011036003.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011036004.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011037001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t011037001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	OMA
NV2t011037001.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	PANTHER
NV2t011037001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011037001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011037001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011037001.1	molecular_function	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2.-, GOC:mah]	OMA
NV2t011037001.1	molecular_function	GO:0019238	cyclohydrolase activity	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah]	OMA
NV2t011037002.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t011037002.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	PANTHER
NV2t011037002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011037003.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t011037003.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	PANTHER
NV2t011037003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011037004.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t011037004.1	biological_process	GO:0006189	'de novo' IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]	PANTHER
NV2t011037004.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011041001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011041001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011043001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011043001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t011043001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t011043001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t011043001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011044001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t011044001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011044001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t011044001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t011044001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t011044001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t011044001.1	molecular_function	GO:0140104	molecular carrier activity	"Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t011045001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t011045001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t011045001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t011047001.1	biological_process	GO:0034499	late endosome to Golgi transport	"The directed movement of substances from late endosomes to the Golgi." [GOC:rb]	PANTHER
NV2t011047001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t011047001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t011049001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011050001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011050001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t011051001.1	biological_process	GO:0006116	NADH oxidation	"A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+." [GOC:ai]	PANTHER
NV2t011051001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011051001.1	molecular_function	GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, PMID:28326]	InterPro
NV2t011051001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t011051002.1	biological_process	GO:0001508	action potential	"A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]	OMA
NV2t011051002.1	biological_process	GO:0001933	negative regulation of protein phosphorylation	"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t011051002.1	biological_process	GO:0002027	regulation of heart rate	"Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]	OMA
NV2t011051002.1	biological_process	GO:0003254	regulation of membrane depolarization	"Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]	OMA
NV2t011051002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t011051002.1	biological_process	GO:0006072	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t011051002.1	biological_process	GO:0006116	NADH oxidation	"A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+." [GOC:ai]	OMA
NV2t011051002.1	biological_process	GO:0006116	NADH oxidation	"A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+." [GOC:ai]	PANTHER
NV2t011051002.1	biological_process	GO:0010765	positive regulation of sodium ion transport	"Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]	OMA
NV2t011051002.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t011051002.1	biological_process	GO:0019725	cellular homeostasis	"Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]	OMA
NV2t011051002.1	biological_process	GO:0033135	regulation of peptidyl-serine phosphorylation	"Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	OMA
NV2t011051002.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t011051002.1	biological_process	GO:0060048	cardiac muscle contraction	"Muscle contraction of cardiac muscle tissue." [GOC:dph]	OMA
NV2t011051002.1	biological_process	GO:0070252	actin-mediated cell contraction	"The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah]	OMA
NV2t011051002.1	biological_process	GO:0071470	cellular response to osmotic stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]	OMA
NV2t011051002.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t011051002.1	biological_process	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t011051002.1	biological_process	GO:2000010	positive regulation of protein localization to cell surface	"Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]	OMA
NV2t011051002.1	biological_process	GO:2000649	regulation of sodium ion transmembrane transporter activity	"Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]	OMA
NV2t011051002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011051002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011051002.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t011051002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011051002.1	molecular_function	GO:0017080	sodium channel regulator activity	"Binds to and modulates the activity of a sodium channel." [GOC:mah]	OMA
NV2t011051002.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t011051002.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t011051002.1	molecular_function	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	OMA
NV2t011051002.1	molecular_function	GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, PMID:28326]	InterPro
NV2t011051002.1	molecular_function	GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, PMID:28326]	OMA
NV2t011051002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t011052001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t011052001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t011052001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011052001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011052001.1	molecular_function	GO:0004890	GABA-A receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]	OMA
NV2t011052001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011054001.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t011054001.1	biological_process	GO:0006564	L-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	InterPro
NV2t011054001.1	biological_process	GO:0009070	serine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t011054001.1	molecular_function	GO:0004617	phosphoglycerate dehydrogenase activity	"Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]	PANTHER
NV2t011054001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t011054001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t011054001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t011054002.1	molecular_function	GO:0004617	phosphoglycerate dehydrogenase activity	"Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]	PANTHER
NV2t011054002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t011055001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t011055001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011055002.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t011055002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011055002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011055003.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t011055003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011056001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011056001.1	biological_process	GO:0050435	amyloid-beta metabolic process	"The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai]	PANTHER
NV2t011056002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011056002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011056002.1	biological_process	GO:0050435	amyloid-beta metabolic process	"The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai]	PANTHER
NV2t011056002.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t011057001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t011057001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t011057002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t011057002.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t011057002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011057002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t011057002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t011057002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011057002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t011057003.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t011057003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011057003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t011057004.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t011057004.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t011058001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t011058001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t011059001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	InterPro
NV2t011061001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011061001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t011062001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011062001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t011062001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011064001.1	biological_process	GO:0010155	regulation of proton transport	"Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm]	OMA
NV2t011064001.1	biological_process	GO:0018022	peptidyl-lysine methylation	"The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]	OMA
NV2t011064001.1	biological_process	GO:0051351	positive regulation of ligase activity	"Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]	OMA
NV2t011064001.1	biological_process	GO:1904058	positive regulation of sensory perception of pain	"Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094]	OMA
NV2t011064001.1	biological_process	GO:1905706	regulation of mitochondrial ATP synthesis coupled proton transport	"Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286]	PANTHER
NV2t011064001.1	biological_process	GO:2001169	regulation of ATP biosynthetic process	"Any process that modulates the frequency, rate or extent of ATP biosynthetic process." [GOC:obol]	OMA
NV2t011064001.1	biological_process	GO:2001259	positive regulation of cation channel activity	"Any process that activates or increases the frequency, rate or extent of cation channel activity." [GOC:BHF]	OMA
NV2t011064001.1	cellular_component	GO:0030061	mitochondrial crista	"Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732]	OMA
NV2t011064001.1	molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]	OMA
NV2t011065001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t011065001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011065001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011065001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t011065001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t011065001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t011065001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t011065001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t011065001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t011065001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t011066001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t011066001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011066001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t011066001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t011066001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011066001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t011067001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011067001.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t011067002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011068001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t011068001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011068001.1	molecular_function	GO:0009922	fatty acid elongase activity	"Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit." [PMID:16564093, PMID:19763486, RHEA:32727]	OMA
NV2t011069001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t011070001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011071001.1	biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]	OMA
NV2t011071001.1	biological_process	GO:0033209	tumor necrosis factor-mediated signaling pathway	"The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t011071001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011071001.1	molecular_function	GO:0051059	NF-kappaB binding	"Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]	OMA
NV2t011071001.1	molecular_function	GO:0051059	NF-kappaB binding	"Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]	PANTHER
NV2t011072001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t011072001.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t011072001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t011072001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t011072001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011072001.1	cellular_component	GO:0048500	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	InterPro
NV2t011072001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t011072001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011072001.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t011072001.1	molecular_function	GO:0030942	endoplasmic reticulum signal peptide binding	"Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah]	InterPro
NV2t011073001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011074001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011075001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011077001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011079001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	InterPro
NV2t011079001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011079002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t011079002.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	InterPro
NV2t011079002.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t011079002.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	OMA
NV2t011079002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011079002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t011079003.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	InterPro
NV2t011079003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011080001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t011083001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011083001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	PANTHER
NV2t011084001.1	biological_process	GO:0008593	regulation of Notch signaling pathway	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	PANTHER
NV2t011084001.1	molecular_function	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]	OMA
NV2t011085001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t011085001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t011085001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	PANTHER
NV2t011085001.1	cellular_component	GO:0001401	SAM complex	"A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361]	InterPro
NV2t011085001.1	cellular_component	GO:0098799	outer mitochondrial membrane protein complex	"Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos]	OMA
NV2t011087001.1	biological_process	GO:0006072	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t011087001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011087001.1	cellular_component	GO:0009331	glycerol-3-phosphate dehydrogenase (FAD) complex	"An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions." [PMID:18296637, PMID:3286606, PMID:7576488]	InterPro
NV2t011087001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t011087001.1	molecular_function	GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3]	OMA
NV2t011087001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011087001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011087001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011088001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t011088001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011090001.1	biological_process	GO:0002009	morphogenesis of an epithelium	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]	OMA
NV2t011090001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011090001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011090001.1	biological_process	GO:0007501	mesodermal cell fate specification	"The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]	OMA
NV2t011090001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t011090001.1	biological_process	GO:0009948	anterior/posterior axis specification	"The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t011090001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t011090001.1	biological_process	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	OMA
NV2t011090001.1	biological_process	GO:0035019	somatic stem cell population maintenance	"Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]	OMA
NV2t011090001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011090001.1	biological_process	GO:0048557	embryonic digestive tract morphogenesis	"The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]	OMA
NV2t011090001.1	biological_process	GO:0048762	mesenchymal cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid]	OMA
NV2t011090001.1	biological_process	GO:0060688	regulation of morphogenesis of a branching structure	"Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph]	OMA
NV2t011090001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t011090001.1	biological_process	GO:0072089	stem cell proliferation	"The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]	OMA
NV2t011090001.1	biological_process	GO:1905330	regulation of morphogenesis of an epithelium	"Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997]	OMA
NV2t011090001.1	biological_process	GO:2000027	regulation of animal organ morphogenesis	"Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol]	OMA
NV2t011090001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011090001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t011090001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011090001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011090001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011093001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t011093001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t011093002.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t011093002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t011094001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t011094001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t011094001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	InterPro
NV2t011094001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	OMA
NV2t011094001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011094001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t011094001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t011094001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t011094001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011094001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011094001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t011094001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t011094002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t011094002.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	InterPro
NV2t011094002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011094002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t011097001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	InterPro
NV2t011097001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t011098001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t011098001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t011098001.1	biological_process	GO:0006431	methionyl-tRNA aminoacylation	"The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t011098001.1	biological_process	GO:0009303	rRNA transcription	"The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732]	OMA
NV2t011098001.1	biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]	OMA
NV2t011098001.1	biological_process	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie]	OMA
NV2t011098001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t011098001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011098001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t011098001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	PANTHER
NV2t011098001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t011098001.1	molecular_function	GO:0004825	methionine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10]	InterPro
NV2t011098001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011100001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	OMA
NV2t011100001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011100001.1	molecular_function	GO:0008482	sulfite oxidase activity	"Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate." [EC:1.8.3.1, RHEA:24600]	OMA
NV2t011100001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011100001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t011100001.1	molecular_function	GO:0030151	molybdenum ion binding	"Binding to a molybdenum ion (Mo)." [GOC:ai]	InterPro
NV2t011100001.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t011100001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t011101001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t011101001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011101001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t011101001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t011102001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t011103001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t011103001.1	biological_process	GO:1901317	regulation of flagellated sperm motility	"Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie]	OMA
NV2t011103001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t011103001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011103001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011104001.1	biological_process	GO:0006499	N-terminal protein myristoylation	"The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah]	InterPro
NV2t011104001.1	biological_process	GO:0006499	N-terminal protein myristoylation	"The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah]	OMA
NV2t011104001.1	biological_process	GO:0018008	N-terminal peptidyl-glycine N-myristoylation	"The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059]	PANTHER
NV2t011104001.1	biological_process	GO:0018193	peptidyl-amino acid modification	"The alteration of an amino acid residue in a peptide." [GOC:mah]	OMA
NV2t011104001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011104001.1	molecular_function	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	"Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]	InterPro
NV2t011104001.1	molecular_function	GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	"Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]	OMA
NV2t011107001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t011107001.1	molecular_function	GO:0017111	ribonucleoside triphosphate phosphatase activity	"Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]	InterPro
NV2t011107001.1	molecular_function	GO:0017111	ribonucleoside triphosphate phosphatase activity	"Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]	OMA
NV2t011107002.1	molecular_function	GO:0017111	ribonucleoside triphosphate phosphatase activity	"Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]	InterPro
NV2t011107003.1	molecular_function	GO:0017111	ribonucleoside triphosphate phosphatase activity	"Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680]	InterPro
NV2t011108001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011108002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011109001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t011109001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t011109001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t011109001.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t011109001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011110001.1	biological_process	GO:0019748	secondary metabolic process	"The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators]	OMA
NV2t011110001.1	biological_process	GO:0019748	secondary metabolic process	"The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators]	PANTHER
NV2t011110001.1	biological_process	GO:0031327	negative regulation of cellular biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t011110001.1	biological_process	GO:0051172	obsolete negative regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t011110001.1	biological_process	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t011110001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011110001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t011110001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t011110001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t011111001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011111002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011112001.1	biological_process	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	OMA
NV2t011112001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t011112001.1	biological_process	GO:0050769	positive regulation of neurogenesis	"Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai]	OMA
NV2t011112001.1	biological_process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429]	PANTHER
NV2t011112001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t011113001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t011113001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t011113001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011113001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011113001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011113001.1	molecular_function	GO:0005518	collagen binding	"Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732]	OMA
NV2t011113001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	OMA
NV2t011113001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t011117001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011117001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t011117001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t011117001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011117001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011117001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011117001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011118001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t011118001.1	biological_process	GO:0042732	D-xylose metabolic process	"The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]	OMA
NV2t011118001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t011118001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t011118001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t011118001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t011118001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t011119001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t011119001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t011119002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t011119002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t011119003.1	biological_process	GO:0030100	regulation of endocytosis	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]	OMA
NV2t011119003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t011119003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011119003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t011119003.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t011119003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011119003.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t011119003.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	OMA
NV2t011119004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t011119004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t011119005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t011119005.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t011120001.1	biological_process	GO:0002699	positive regulation of immune effector process	"Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]	OMA
NV2t011120001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t011120001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t011120001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t011120001.1	biological_process	GO:0046887	positive regulation of hormone secretion	"Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai]	OMA
NV2t011120001.1	biological_process	GO:0050729	positive regulation of inflammatory response	"Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]	OMA
NV2t011120001.1	biological_process	GO:0050778	positive regulation of immune response	"Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	OMA
NV2t011120001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t011120001.1	biological_process	GO:1903307	positive regulation of regulated secretory pathway	"Any process that activates or increases the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776]	OMA
NV2t011120001.1	biological_process	GO:2000786	positive regulation of autophagosome assembly	"Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t011120001.1	biological_process	GO:2000786	positive regulation of autophagosome assembly	"Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF]	PANTHER
NV2t011120001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t011120001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011120001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t011120001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t011120001.1	molecular_function	GO:0005154	epidermal growth factor receptor binding	"Binding to an epidermal growth factor receptor." [GOC:ai]	OMA
NV2t011120001.1	molecular_function	GO:0005158	insulin receptor binding	"Binding to an insulin receptor." [GOC:ai]	OMA
NV2t011120001.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	OMA
NV2t011120001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t011122001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t011122001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t011122001.1	biological_process	GO:0033119	negative regulation of RNA splicing	"Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah]	OMA
NV2t011122001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t011122001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t011122001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t011122001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t011122001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t011122001.1	molecular_function	GO:0048027	mRNA 5'-UTR binding	"Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]	OMA
NV2t011122001.1	molecular_function	GO:0070181	small ribosomal subunit rRNA binding	"Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh]	PANTHER
NV2t011123001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011123001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t011123001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t011125001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011125001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t011125001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t011127001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011127001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t011127001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t011129001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	OMA
NV2t011129001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011129001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011129001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011129001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011129001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t011129001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t011129001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t011132001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011132001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011132001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011134001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011134001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011134001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011138001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011138001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011139001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t011139001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011139001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t011139001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011139001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011139001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011140002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011140002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011140002.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011140002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011140002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t011141001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011141001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011142001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011144001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011144002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011145001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t011145001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011145001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t011146001.1	biological_process	GO:0030322	stabilization of membrane potential	"The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t011146001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t011146001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011146001.1	molecular_function	GO:0015271	outward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]	OMA
NV2t011146001.1	molecular_function	GO:0022841	potassium ion leak channel activity	"Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011147001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t011147001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	PANTHER
NV2t011147001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t011147001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t011150001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t011150001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011150001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011150001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011150001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t011150001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	PANTHER
NV2t011152001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	OMA
NV2t011152001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t011152001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t011152001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t011152001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	PANTHER
NV2t011152001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011152001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011152001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t011152001.1	molecular_function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]	OMA
NV2t011153001.1	biological_process	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	InterPro
NV2t011153001.1	biological_process	GO:0030422	siRNA processing	"A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase." [GOC:mah, PMID:11524674, PMID:19239886, PMID:20687832]	OMA
NV2t011153001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011153001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011153001.1	cellular_component	GO:1902555	endoribonuclease complex	"A protein complex which is capable of endoribonuclease activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t011153001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t011153001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011153001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t011153001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011153001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t011154001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t011154001.1	biological_process	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	InterPro
NV2t011154001.1	biological_process	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	OMA
NV2t011154001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t011154001.1	cellular_component	GO:0008541	proteasome regulatory particle, lid subcomplex	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]	PANTHER
NV2t011154001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011154001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t011155001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011155002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011156001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t011157001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t011157001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t011157001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011157001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t011157001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t011157001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t011157001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t011157001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011158001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011158001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t011158001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t011160001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t011160001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t011160001.1	biological_process	GO:0006268	DNA unwinding involved in DNA replication	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]	OMA
NV2t011160001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t011160001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t011160001.1	biological_process	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	OMA
NV2t011160001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	InterPro
NV2t011160001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	OMA
NV2t011160001.1	cellular_component	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	OMA
NV2t011160001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t011160001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011160001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011160001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t011160001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	OMA
NV2t011160001.1	molecular_function	GO:1990518	single-stranded 3'-5' DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'." [PMID:25165823]	PANTHER
NV2t011161001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011161001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011163001.1	biological_process	GO:0006560	proline metabolic process	"The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t011163001.1	biological_process	GO:0006561	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	InterPro
NV2t011163001.1	biological_process	GO:0009084	glutamine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t011163001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t011163001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t011163001.1	biological_process	GO:0055129	L-proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd]	PANTHER
NV2t011163001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t011163001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011163001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t011164001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011164001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011164002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011164002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011164002.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t011164003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011164003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011164004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011164004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011165001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t011167001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t011167001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t011167001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t011167001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011167001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t011167001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t011168001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011168001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011168001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t011168001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t011168001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011168001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011168001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011169001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011169001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011169001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t011169001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t011169001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011169001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011169001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011172001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t011172001.1	biological_process	GO:0007528	neuromuscular junction development	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]	OMA
NV2t011172001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t011172001.1	biological_process	GO:1901385	regulation of voltage-gated calcium channel activity	"Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie]	OMA
NV2t011172001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t011172001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011172001.1	molecular_function	GO:0008331	high voltage-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]	OMA
NV2t011173001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t011173001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t011173001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	InterPro
NV2t011173001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t011173001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t011173001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011173001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t011173001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t011174001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t011174001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011175001.1	biological_process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	OMA
NV2t011175001.1	biological_process	GO:0000958	mitochondrial mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]	OMA
NV2t011175001.1	biological_process	GO:0002082	regulation of oxidative phosphorylation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph]	OMA
NV2t011175001.1	biological_process	GO:0043331	response to dsRNA	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl]	OMA
NV2t011175001.1	biological_process	GO:0044528	regulation of mitochondrial mRNA stability	"Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs." [GOC:al, GOC:jl]	OMA
NV2t011175001.1	biological_process	GO:0045069	regulation of viral genome replication	"Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai]	OMA
NV2t011175001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t011175001.1	biological_process	GO:0048524	positive regulation of viral process	"Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]	OMA
NV2t011175001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t011175001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t011175001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t011175001.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t011175001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t011175001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t011175001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011175001.1	molecular_function	GO:0004535	poly(A)-specific ribonuclease activity	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]	OMA
NV2t011177001.1	biological_process	GO:1903565	negative regulation of protein localization to cilium	"Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986]	PANTHER
NV2t011180001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t011181001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011181001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011183001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011183001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011184001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t011184001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011184001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011185001.1	biological_process	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	InterPro
NV2t011187001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t011187001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	InterPro
NV2t011187001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	OMA
NV2t011189001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t011189001.1	biological_process	GO:0033260	nuclear DNA replication	"The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t011189001.1	biological_process	GO:0033260	nuclear DNA replication	"The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]	PANTHER
NV2t011189001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	OMA
NV2t011189001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011189001.1	cellular_component	GO:0030894	replisome	"A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]	OMA
NV2t011191001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011191001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t011191001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011191001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t011192001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011192001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011192001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011192002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011192002.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192003.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192004.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192005.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192006.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192007.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192008.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192009.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192010.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011192011.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	PANTHER
NV2t011192011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011195001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011195001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011195001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011195001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011196001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	InterPro
NV2t011196001.1	molecular_function	GO:0047223	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN]	PANTHER
NV2t011196002.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	InterPro
NV2t011196002.1	molecular_function	GO:0047223	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN]	PANTHER
NV2t011197001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t011197001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011197001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t011198001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011198001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011199001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t011199002.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t011199003.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t011199004.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t011200001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011201001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t011201001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t011201001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	InterPro
NV2t011201001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t011201001.1	molecular_function	GO:0140103	catalytic activity, acting on a glycoprotein	"Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t011201002.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	InterPro
NV2t011201002.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t011202001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t011202001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t011202001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t011202001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t011202001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t011202001.1	biological_process	GO:0071985	multivesicular body sorting pathway	"A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]	InterPro
NV2t011202001.1	biological_process	GO:0072666	establishment of protein localization to vacuole	"The directed movement of a protein to a specific location in a vacuole." [GOC:mah]	OMA
NV2t011202001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t011202001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t011202001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t011202001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t011202001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t011203001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t011203001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011203001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t011203001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t011203001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	PANTHER
NV2t011204001.1	biological_process	GO:0033499	galactose catabolic process via UDP-galactose	"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821]	PANTHER
NV2t011205001.1	cellular_component	GO:0000123	histone acetyltransferase complex	"A protein complex that possesses histone acetyltransferase activity." [GOC:mah]	OMA
NV2t011205001.1	cellular_component	GO:0044545	NSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]	PANTHER
NV2t011207001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011207001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t011207001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t011210001.1	biological_process	GO:0033119	negative regulation of RNA splicing	"Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah]	OMA
NV2t011210001.1	biological_process	GO:0034620	cellular response to unfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]	OMA
NV2t011210001.1	biological_process	GO:0060702	negative regulation of endoribonuclease activity	"Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]	OMA
NV2t011210001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t011210001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t011210001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t011210001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t011211001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	InterPro
NV2t011211001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t011212001.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	InterPro
NV2t011212001.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	OMA
NV2t011212001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t011212001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011213001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011217001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t011218001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t011218001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t011218001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t011218001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t011218001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011218001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t011218001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011219001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t011219001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011219001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t011219001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t011219001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t011219001.1	biological_process	GO:0071985	multivesicular body sorting pathway	"A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]	InterPro
NV2t011219001.1	biological_process	GO:0071985	multivesicular body sorting pathway	"A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]	OMA
NV2t011219001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t011219001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t011219001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011219001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t011219001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t011219001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t011219001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011224001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t011224001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011224001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t011224001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011224001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t011224002.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t011224002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011224003.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t011224003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011224004.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t011224004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011224005.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t011224005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011225001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011225001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011226001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011226001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t011226002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011226002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t011228001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011228001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	PANTHER
NV2t011228001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011228001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011229001.1	molecular_function	GO:0030552	cAMP binding	"Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]	PANTHER
NV2t011230001.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	OMA
NV2t011230001.1	biological_process	GO:0018343	protein farnesylation	"The covalent attachment of a farnesyl group to a protein." [GOC:jl]	InterPro
NV2t011230001.1	biological_process	GO:0018343	protein farnesylation	"The covalent attachment of a farnesyl group to a protein." [GOC:jl]	PANTHER
NV2t011230001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011230001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t011230001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011230001.1	molecular_function	GO:0008318	protein prenyltransferase activity	"Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]	OMA
NV2t011234001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	PANTHER
NV2t011238001.1	biological_process	GO:0045010	actin nucleation	"The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]	InterPro
NV2t011238001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011242001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011242001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011243001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011245001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011245001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011247001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011247001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011248001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t011248001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t011249001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t011249001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t011249001.1	molecular_function	GO:0050185	phosphatidylinositol deacylase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+." [EC:3.1.1.52, RHEA:18001]	PANTHER
NV2t011250001.1	biological_process	GO:0006171	cAMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732]	InterPro
NV2t011250001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t011250001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011252001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t011252001.1	cellular_component	GO:0005854	nascent polypeptide-associated complex	"A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149]	OMA
NV2t011252001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t011252001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t011253001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t011253001.1	molecular_function	GO:0009975	cyclase activity	"Catalysis of a ring closure reaction." [ISBN:0198547684]	OMA
NV2t011253001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t011253001.1	molecular_function	GO:0047820	D-glutamate cyclase activity	"Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [EC:4.2.1.48, RHEA:22360]	PANTHER
NV2t011256001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011256001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011256001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011256001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011256001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t011256001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011256001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011257001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t011257001.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t011257001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t011257001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t011257001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011257001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011257001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011257001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011257001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t011257001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t011257001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t011257001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t011259001.1	biological_process	GO:0001516	prostaglandin biosynthetic process	"The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai]	OMA
NV2t011259001.1	biological_process	GO:0001676	long-chain fatty acid metabolic process	"The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [GOC:ajp]	OMA
NV2t011259001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t011259001.1	biological_process	GO:0120254	olefinic compound metabolic process	"The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc]	OMA
NV2t011259001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011259001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t011259001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t011259001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	OMA
NV2t011259001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011259001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t011259001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t011259001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t011259001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t011262001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011262001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011262001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011264001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011264001.1	biological_process	GO:0061099	negative regulation of protein tyrosine kinase activity	"Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]	PANTHER
NV2t011267001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t011267001.1	biological_process	GO:0043200	response to amino acid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg]	OMA
NV2t011267001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t011267001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011267001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011267001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011269001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t011269001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011269001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t011269001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t011269001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011269002.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t011269002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011269003.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t011269004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011269004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011270001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011270001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011270001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t011270001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t011270001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011270001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011270001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011271001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t011271001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t011271001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	InterPro
NV2t011271001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t011271001.1	molecular_function	GO:0047223	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN]	PANTHER
NV2t011276001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011276002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011278001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t011280001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t011280001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t011280001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	InterPro
NV2t011280001.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t011280001.1	molecular_function	GO:0140103	catalytic activity, acting on a glycoprotein	"Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t011280002.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	InterPro
NV2t011280002.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t011280003.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t011280004.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	InterPro
NV2t011280004.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	PANTHER
NV2t011280005.1	molecular_function	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]	InterPro
NV2t011281001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011282001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t011282001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	PANTHER
NV2t011282001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011282001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t011282001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t011282001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011282001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t011282001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t011282002.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	PANTHER
NV2t011282002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t011282002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011282002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t011283001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011285001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011286001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t011286001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t011286001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011286001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011286002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t011288001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t011288002.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t011294001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011298001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t011298001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011298001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011299001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011299001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011299001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t011300001.1	biological_process	GO:0051660	establishment of centrosome localization	"The directed movement of the centrosome to a specific location." [GOC:ai]	PANTHER
NV2t011300001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011300002.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t011300002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t011300002.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t011300002.1	biological_process	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t011300002.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	OMA
NV2t011300002.1	biological_process	GO:0051642	centrosome localization	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t011300002.1	biological_process	GO:0051649	establishment of localization in cell	"Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	OMA
NV2t011300002.1	biological_process	GO:0051656	establishment of organelle localization	"The directed movement of an organelle to a specific location." [GOC:ai]	OMA
NV2t011300002.1	biological_process	GO:0051660	establishment of centrosome localization	"The directed movement of the centrosome to a specific location." [GOC:ai]	PANTHER
NV2t011300002.1	cellular_component	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	OMA
NV2t011300002.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t011300002.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t011300002.1	cellular_component	GO:0043296	apical junction complex	"A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]	OMA
NV2t011300002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011300002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t011300003.1	biological_process	GO:0051660	establishment of centrosome localization	"The directed movement of the centrosome to a specific location." [GOC:ai]	PANTHER
NV2t011300003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011300004.1	biological_process	GO:0051660	establishment of centrosome localization	"The directed movement of the centrosome to a specific location." [GOC:ai]	PANTHER
NV2t011300005.1	biological_process	GO:0051660	establishment of centrosome localization	"The directed movement of the centrosome to a specific location." [GOC:ai]	PANTHER
NV2t011301001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t011301001.1	biological_process	GO:0006426	glycyl-tRNA aminoacylation	"The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t011301001.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t011301001.1	biological_process	GO:0070127	tRNA aminoacylation for mitochondrial protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah]	OMA
NV2t011301001.1	biological_process	GO:0070150	mitochondrial glycyl-tRNA aminoacylation	"The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]	PANTHER
NV2t011301001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011301001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t011301001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t011301001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t011301001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011301001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t011301001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t011301001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t011301002.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t011301002.1	biological_process	GO:0006426	glycyl-tRNA aminoacylation	"The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t011301002.1	biological_process	GO:0070150	mitochondrial glycyl-tRNA aminoacylation	"The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]	PANTHER
NV2t011302001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011302001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t011302001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011302002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011302002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t011302002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011302003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011302003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t011302003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011304001.1	biological_process	GO:1901987	regulation of cell cycle phase transition	"Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]	PANTHER
NV2t011304001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011306001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t011306001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011308001.1	biological_process	GO:0000965	mitochondrial RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]	OMA
NV2t011308001.1	biological_process	GO:0042780	tRNA 3'-end processing	"The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators]	OMA
NV2t011308001.1	biological_process	GO:0090646	mitochondrial tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw]	OMA
NV2t011308001.1	biological_process	GO:1990180	mitochondrial tRNA 3'-end processing	"The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:mah, GOC:TermGenie, PMID:23928301]	PANTHER
NV2t011308001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011308001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t011308001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t011308001.1	molecular_function	GO:0070566	adenylyltransferase activity	"Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]	OMA
NV2t011308001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t011309001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t011309001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t011309001.1	biological_process	GO:0031532	obsolete actin cytoskeleton reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]	OMA
NV2t011309001.1	biological_process	GO:0051491	positive regulation of filopodium assembly	"Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t011309001.1	biological_process	GO:0051668	localization within membrane	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai]	OMA
NV2t011309001.1	biological_process	GO:0072655	establishment of protein localization to mitochondrion	"The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah]	OMA
NV2t011309001.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t011309001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011309001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t011309001.1	cellular_component	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]	OMA
NV2t011309001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t011309001.1	cellular_component	GO:0032154	cleavage furrow	"The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409]	OMA
NV2t011309001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t011309001.1	molecular_function	GO:0003925	G protein activity	"A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]	OMA
NV2t011309001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011309001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011309001.1	molecular_function	GO:0017022	myosin binding	"Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah]	OMA
NV2t011309001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t011309001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t011311001.1	biological_process	GO:0016239	positive regulation of macroautophagy	"Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]	OMA
NV2t011311001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t011311001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t011311001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t011311001.1	cellular_component	GO:0005774	vacuolar membrane	"The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]	OMA
NV2t011311001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011311001.1	cellular_component	GO:0061700	GATOR2 complex	"A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins." [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700]	OMA
NV2t011311001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011312001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011312001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t011312001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t011312001.1	molecular_function	GO:0061799	cyclic pyranopterin monophosphate synthase activity	"Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate." [GOC:dph, GOC:ik, PMID:25896388]	PANTHER
NV2t011312002.1	biological_process	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]	InterPro
NV2t011312002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011312002.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t011312002.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t011312002.1	molecular_function	GO:0061799	cyclic pyranopterin monophosphate synthase activity	"Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate." [GOC:dph, GOC:ik, PMID:25896388]	PANTHER
NV2t011312003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011312003.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t011312003.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t011312003.1	molecular_function	GO:0061799	cyclic pyranopterin monophosphate synthase activity	"Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate." [GOC:dph, GOC:ik, PMID:25896388]	PANTHER
NV2t011313001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t011313001.1	cellular_component	GO:0071014	post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]	PANTHER
NV2t011313001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011314001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t011314001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011315001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t011317001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	OMA
NV2t011317001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t011317001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t011317001.1	molecular_function	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]	OMA
NV2t011317002.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t011318001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t011318001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t011318001.1	molecular_function	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2.-, GOC:mah]	OMA
NV2t011318001.1	molecular_function	GO:0016840	carbon-nitrogen lyase activity	"Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]	OMA
NV2t011318001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t011318001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t011318001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t011318001.1	molecular_function	GO:0072341	modified amino acid binding	"Binding to a modified amino acid." [GOC:mah]	OMA
NV2t011318001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t011318001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t011318002.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t011318002.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t011319001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t011319001.1	biological_process	GO:0007229	integrin-mediated signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t011319001.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	PANTHER
NV2t011319001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	OMA
NV2t011319001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t011319002.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	PANTHER
NV2t011319003.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	PANTHER
NV2t011321001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011321001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011321001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011321001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011325001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011325001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t011325001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011326001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t011327001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011327001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011327001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011328001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t011328001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011328001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t011328001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t011328001.1	biological_process	GO:0048753	pigment granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]	OMA
NV2t011328001.1	biological_process	GO:0060326	cell chemotaxis	"The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]	OMA
NV2t011328001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	OMA
NV2t011328001.1	biological_process	GO:1903426	regulation of reactive oxygen species biosynthetic process	"Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	OMA
NV2t011328001.1	biological_process	GO:1903426	regulation of reactive oxygen species biosynthetic process	"Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	PANTHER
NV2t011328001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t011328001.1	molecular_function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+." [EC:2.7.1.150, RHEA:13609]	InterPro
NV2t011328001.1	molecular_function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+." [EC:2.7.1.150, RHEA:13609]	OMA
NV2t011328001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011328001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011328001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011328001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t011328001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	InterPro
NV2t011328001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	OMA
NV2t011328002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011328002.1	biological_process	GO:1903426	regulation of reactive oxygen species biosynthetic process	"Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	PANTHER
NV2t011328002.1	molecular_function	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	"Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+." [EC:2.7.1.150, RHEA:13609]	InterPro
NV2t011328002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011328002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011328002.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	InterPro
NV2t011330001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011330001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t011331001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t011331001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t011331001.1	molecular_function	GO:0003774	cytoskeletal motor activity	"Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]	OMA
NV2t011331001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011331001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011332001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011332001.1	biological_process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]	PANTHER
NV2t011332001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011332002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011332002.1	biological_process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]	PANTHER
NV2t011332002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011332003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011332003.1	biological_process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]	PANTHER
NV2t011332003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011332004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011332004.1	biological_process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]	PANTHER
NV2t011332004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011332005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011332005.1	biological_process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]	PANTHER
NV2t011332005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011333001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t011333001.1	cellular_component	GO:0005684	U2-type spliceosomal complex	"Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900]	PANTHER
NV2t011333001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t011333001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t011333001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t011334001.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t011334001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011334002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011334003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011334004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011338002.1	molecular_function	GO:0016427	tRNA (cytidine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [GOC:go-curators]	OMA
NV2t011339001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t011339001.1	biological_process	GO:0016925	protein sumoylation	"The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]	OMA
NV2t011339001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t011339001.1	biological_process	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	OMA
NV2t011339001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011339001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t011339001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t011339001.1	biological_process	GO:0071276	cellular response to cadmium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah]	OMA
NV2t011339001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t011339001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t011339001.1	cellular_component	GO:0097165	nuclear stress granule	"A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:10359787, PMID:12865437]	OMA
NV2t011339001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011339001.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	OMA
NV2t011339001.1	molecular_function	GO:0031386	protein tag activity	"A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]	OMA
NV2t011339001.1	molecular_function	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	OMA
NV2t011339001.1	molecular_function	GO:0044389	ubiquitin-like protein ligase binding	"Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]	PANTHER
NV2t011340001.1	cellular_component	GO:0072487	MSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]	InterPro
NV2t011342001.1	cellular_component	GO:0072487	MSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]	InterPro
NV2t011343001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011343001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011343001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011343001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011345001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t011345001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011345002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t011345002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011345003.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t011345003.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011345004.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t011345004.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011345005.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t011345005.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011346001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011346001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011346002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011346002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011346003.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011347001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t011347001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t011347001.1	biological_process	GO:0006687	glycosphingolipid metabolic process	"The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]	OMA
NV2t011347001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t011347001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t011347001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011347001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	OMA
NV2t011347001.1	molecular_function	GO:0008422	beta-glucosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21, PMID:12594539]	PANTHER
NV2t011348001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011350001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t011350001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t011350001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t011352001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t011352001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t011352001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t011352002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t011352002.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t011352003.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t011352003.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t011353001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t011353001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t011355001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t011355001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011355001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t011355001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011356001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011357001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t011357001.1	biological_process	GO:0006108	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t011357001.1	biological_process	GO:0006734	NADH metabolic process	"The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t011357001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011357001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t011357001.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	OMA
NV2t011357001.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	PANTHER
NV2t011358001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t011358001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t011358001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t011358001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t011359001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011359001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t011359001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t011359001.1	biological_process	GO:0035522	obsolete monoubiquitinated histone H2A deubiquitination	"OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]	OMA
NV2t011359001.1	biological_process	GO:0043966	obsolete histone H3 acetylation	"OBSOLETE. The modification of histone H3 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t011359001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t011359001.1	cellular_component	GO:0071819	DUBm complex	"A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473]	OMA
NV2t011359001.1	cellular_component	GO:0071819	DUBm complex	"A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473]	PANTHER
NV2t011359001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t011360001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t011360001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011360001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t011360001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011360001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011360001.1	cellular_component	GO:0032391	photoreceptor connecting cilium	"The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone." [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680]	OMA
NV2t011360001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t011360001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	InterPro
NV2t011360001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t011360001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011361001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t011361002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t011362001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t011362001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t011362001.1	cellular_component	GO:0034657	GID complex	"A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species." [PMID:12686616, PMID:18508925, PMID:35682545]	OMA
NV2t011362001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011364001.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	PANTHER
NV2t011364001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011365001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011365001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011366001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011366001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t011366001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t011366001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011366001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011366001.1	molecular_function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]	OMA
NV2t011366001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011366001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011367002.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	PANTHER
NV2t011367002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011367003.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	PANTHER
NV2t011367003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011367004.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	PANTHER
NV2t011367004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011367005.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	PANTHER
NV2t011367005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011368001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t011370001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t011370001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011373001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011373001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011373001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011373002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011373002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011375001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t011375001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011376001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	InterPro
NV2t011376001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t011378001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011378001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011378001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011380001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011380001.1	biological_process	GO:0051960	regulation of nervous system development	"Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	PANTHER
NV2t011380001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011382001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t011382001.1	molecular_function	GO:0008097	5S rRNA binding	"Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]	InterPro
NV2t011382002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t011382002.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t011382002.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t011382002.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t011382002.1	molecular_function	GO:0008097	5S rRNA binding	"Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]	InterPro
NV2t011382002.1	molecular_function	GO:0008097	5S rRNA binding	"Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]	OMA
NV2t011383001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011383001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	InterPro
NV2t011383002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011383002.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	InterPro
NV2t011383003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011383003.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	InterPro
NV2t011384001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t011384001.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t011384001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t011384001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011384002.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t011384002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011384003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t011384003.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t011384003.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t011384003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011384004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t011384004.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t011384004.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t011384004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011384005.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t011384005.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t011384005.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t011384005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011384006.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t011384006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011385001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011385002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011385002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t011386001.1	molecular_function	GO:0015036	disulfide oxidoreductase activity	"Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators]	PANTHER
NV2t011388001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011388001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011390001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t011390001.1	biological_process	GO:0036316	SREBP-SCAP complex retention in endoplasmic reticulum	"Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER." [GOC:bf, PMID:16525117]	PANTHER
NV2t011390001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t011392001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t011392001.1	biological_process	GO:0022600	digestive system process	"A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]	OMA
NV2t011392001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t011392001.1	biological_process	GO:0046717	acid secretion	"The controlled release of acid by a cell or a tissue." [GOC:ai]	OMA
NV2t011392001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t011392001.1	biological_process	GO:1903522	regulation of blood circulation	"Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]	OMA
NV2t011392001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011392001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t011392001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t011393001.1	biological_process	GO:0043490	malate-aspartate shuttle	"The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]	PANTHER
NV2t011393001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011393001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t011393001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011393001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011394001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011394001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t011394001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t011395001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t011395001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t011395001.1	molecular_function	GO:0008525	phosphatidylcholine transporter activity	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]	OMA
NV2t011395001.1	molecular_function	GO:0031210	phosphatidylcholine binding	"Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t011395001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t011395001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t011397001.1	biological_process	GO:0006105	succinate metabolic process	"The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732]	OMA
NV2t011397001.1	biological_process	GO:0034553	mitochondrial respiratory chain complex II assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]	OMA
NV2t011397001.1	biological_process	GO:0034553	mitochondrial respiratory chain complex II assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]	PANTHER
NV2t011397001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t011398001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t011398001.1	biological_process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	InterPro
NV2t011398001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t011398001.1	biological_process	GO:0046339	diacylglycerol metabolic process	"The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11481335]	OMA
NV2t011398001.1	biological_process	GO:0046834	lipid phosphorylation	"The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732]	OMA
NV2t011398001.1	biological_process	GO:0046834	lipid phosphorylation	"The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732]	PANTHER
NV2t011398001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011398001.1	molecular_function	GO:0004143	ATP-dependent diacylglycerol kinase activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+." [GOC:elh, RHEA:10272]	OMA
NV2t011398001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011398001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011398001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t011401001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011403001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011403001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t011403001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t011406001.1	biological_process	GO:0008218	bioluminescence	"The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]	InterPro
NV2t011406001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t011409001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t011409001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011409001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011409001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011410001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t011411001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t011411001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011411002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011411002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011411002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011411002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011412001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t011412001.1	biological_process	GO:0032781	positive regulation of ATP-dependent activity	"Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah]	OMA
NV2t011412001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t011412001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011412001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011412001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t011412001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	OMA
NV2t011412001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	PANTHER
NV2t011412001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t011412001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t011413001.1	biological_process	GO:0006370	7-methylguanosine mRNA capping	"The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:mah, PMID:9266685]	OMA
NV2t011413001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t011413001.1	biological_process	GO:0097309	obsolete cap1 mRNA methylation	"OBSOLETE. Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356]	OMA
NV2t011413001.1	biological_process	GO:0097309	obsolete cap1 mRNA methylation	"OBSOLETE. Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356]	PANTHER
NV2t011413001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011413001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011413001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011413001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011413001.1	molecular_function	GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57]	OMA
NV2t011413001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011414001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t011414001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t011415001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011415001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t011415001.1	biological_process	GO:0051353	positive regulation of oxidoreductase activity	"Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]	OMA
NV2t011415001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011415001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t011415001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t011416001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	InterPro
NV2t011416001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	OMA
NV2t011416002.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	InterPro
NV2t011417001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011419001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011419002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011419003.1	biological_process	GO:0032101	regulation of response to external stimulus	"Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t011419003.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t011419003.1	biological_process	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t011419003.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t011419003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011420001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t011421001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t011422001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t011422001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011422001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t011422001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t011422001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t011423001.1	biological_process	GO:0031591	wybutosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]	PANTHER
NV2t011423001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t011423001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011423002.1	biological_process	GO:0031591	wybutosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]	PANTHER
NV2t011423002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011425001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	InterPro
NV2t011427001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t011427001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t011427001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t011427001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t011427001.1	cellular_component	GO:1990745	EARP complex	"A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]	InterPro
NV2t011427001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t011427002.1	cellular_component	GO:1990745	EARP complex	"A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]	InterPro
NV2t011427003.1	cellular_component	GO:1990745	EARP complex	"A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]	InterPro
NV2t011427004.1	cellular_component	GO:1990745	EARP complex	"A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]	InterPro
NV2t011429001.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	InterPro
NV2t011430001.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011430001.1	biological_process	GO:2000234	positive regulation of rRNA processing	"Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah]	PANTHER
NV2t011430001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t011430001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011430001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011430002.1	biological_process	GO:2000234	positive regulation of rRNA processing	"Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah]	PANTHER
NV2t011430002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011430003.1	biological_process	GO:2000234	positive regulation of rRNA processing	"Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah]	PANTHER
NV2t011430004.1	biological_process	GO:2000234	positive regulation of rRNA processing	"Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah]	PANTHER
NV2t011430004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011431001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t011431001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011433001.1	biological_process	GO:0001654	eye development	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]	OMA
NV2t011433001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t011433001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t011433001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t011433001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011433001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011433001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011433001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011433001.1	molecular_function	GO:0008201	heparin binding	"Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t011433001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	OMA
NV2t011433002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011433002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011433002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011433003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011433003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011433003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011433004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011433004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011433004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011433005.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011433005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011433005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011433006.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011433006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011433006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011434001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011434001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011434001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011434001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011434001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011435001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t011435001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	PANTHER
NV2t011435001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t011436001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011436001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t011436002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011436002.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t011436002.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t011436002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t011436002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t011436002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t011437001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t011437001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t011437001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011437001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011438001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011439001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t011439001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011440001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t011440001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011441001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011441001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t011441001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t011441001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011441001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t011441002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011441002.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t011441002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011441003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t011441003.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t011441003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011446001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011446001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011446001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t011447001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011447001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t011447001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t011447001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t011447001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011448001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t011448001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t011448001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011449001.1	biological_process	GO:0000291	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]	OMA
NV2t011449001.1	biological_process	GO:0006304	DNA modification	"The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]	OMA
NV2t011449001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t011449001.1	biological_process	GO:0008334	histone mRNA metabolic process	"The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:krc, GOC:mah, PMID:17855393]	OMA
NV2t011449001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t011449001.1	biological_process	GO:0031126	sno(s)RNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea." [GOC:krc, GOC:mah, PMID:17284456]	OMA
NV2t011449001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t011449001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t011449001.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t011449001.1	biological_process	GO:0071027	nuclear RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]	OMA
NV2t011449001.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t011449001.1	cellular_component	GO:0000176	nuclear exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t011449001.1	cellular_component	GO:0000791	euchromatin	"A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]	OMA
NV2t011449001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t011449001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011449001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011449001.1	molecular_function	GO:0035925	mRNA 3'-UTR AU-rich region binding	"Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]	OMA
NV2t011450001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t011450001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t011450001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t011450001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t011450001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	OMA
NV2t011450001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	InterPro
NV2t011450001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t011451001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t011451001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t011451001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t011451001.1	biological_process	GO:0045324	late endosome to vacuole transport	"The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]	PANTHER
NV2t011452001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	OMA
NV2t011452001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	PANTHER
NV2t011452001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t011453001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t011453001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t011453001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t011453001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t011453002.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t011454001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011454001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t011454001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t011454001.1	biological_process	GO:0009595	detection of biotic stimulus	"The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb]	OMA
NV2t011454001.1	biological_process	GO:0009894	regulation of catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]	OMA
NV2t011454001.1	biological_process	GO:0010631	epithelial cell migration	"The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t011454001.1	biological_process	GO:0010716	negative regulation of extracellular matrix disassembly	"Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t011454001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t011454001.1	biological_process	GO:0050673	epithelial cell proliferation	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]	OMA
NV2t011454001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t011454001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t011454001.1	biological_process	GO:1900117	regulation of execution phase of apoptosis	"Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie]	OMA
NV2t011454001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t011454001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011454001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t011454001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t011454001.1	cellular_component	GO:1905368	peptidase complex	"A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	OMA
NV2t011454001.1	molecular_function	GO:0002020	protease binding	"Binding to a protease or a peptidase." [GOC:hjd]	OMA
NV2t011454001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t011454001.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t011454001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011454001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t011454001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t011454001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t011455001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t011455001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011455001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t011455001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011455001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011455001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011455001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011455002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t011455002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011457001.1	biological_process	GO:0019344	cysteine biosynthetic process	"The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]	PANTHER
NV2t011459001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011459001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011459002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011459002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011460001.1	biological_process	GO:0000097	sulfur amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]	OMA
NV2t011460001.1	biological_process	GO:0009070	serine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t011460001.1	biological_process	GO:0019343	cysteine biosynthetic process via cystathionine	"The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators]	InterPro
NV2t011460001.1	biological_process	GO:0019344	cysteine biosynthetic process	"The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]	PANTHER
NV2t011460001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011460001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t011460002.1	biological_process	GO:0019343	cysteine biosynthetic process via cystathionine	"The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators]	InterPro
NV2t011460002.1	biological_process	GO:0019344	cysteine biosynthetic process	"The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]	PANTHER
NV2t011460003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011460003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t011462001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t011462001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t011462001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	OMA
NV2t011462001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	PANTHER
NV2t011463001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011463001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011463001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011463002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011463002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t011463002.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t011463002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011463002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011463002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011463002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t011463003.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011463003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011463003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011463004.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011463004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011463004.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011464001.1	biological_process	GO:0033306	phytol metabolic process	"The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah]	PANTHER
NV2t011465001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t011465001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t011465001.1	cellular_component	GO:0000808	origin recognition complex	"A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]	OMA
NV2t011465001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011466001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t011466001.1	biological_process	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	OMA
NV2t011466001.1	biological_process	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	PANTHER
NV2t011466001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011466001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011466001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011466001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t011466001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t011468001.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	OMA
NV2t011468001.1	biological_process	GO:0009446	putrescine biosynthetic process	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t011468001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t011468001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t011468001.1	molecular_function	GO:0047632	agmatine deiminase activity	"Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]	PANTHER
NV2t011473001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011473001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011473001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t011474001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011474001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t011474001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011474001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t011474001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t011474001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011474001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011475001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011475002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011477001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t011477001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t011477001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011477001.1	biological_process	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	OMA
NV2t011477001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t011477001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011477001.1	cellular_component	GO:0008091	spectrin	"Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194]	InterPro
NV2t011477001.1	cellular_component	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]	OMA
NV2t011477001.1	cellular_component	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	OMA
NV2t011477001.1	cellular_component	GO:0031430	M band	"The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194]	OMA
NV2t011477001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t011477001.1	cellular_component	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t011477001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t011477001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011477001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t011477001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t011477001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t011477001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011480001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t011480001.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t011480001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t011482001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011482002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011483001.1	biological_process	GO:0010587	miRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]	PANTHER
NV2t011484001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011488001.1	molecular_function	GO:0070567	cytidylyltransferase activity	"Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]	InterPro
NV2t011488001.1	molecular_function	GO:0070567	cytidylyltransferase activity	"Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]	PANTHER
NV2t011490001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t011490001.1	molecular_function	GO:0070567	cytidylyltransferase activity	"Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]	PANTHER
NV2t011490002.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t011490002.1	molecular_function	GO:0070567	cytidylyltransferase activity	"Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]	InterPro
NV2t011490002.1	molecular_function	GO:0070567	cytidylyltransferase activity	"Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]	PANTHER
NV2t011490003.1	molecular_function	GO:0070567	cytidylyltransferase activity	"Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]	PANTHER
NV2t011491001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	InterPro
NV2t011493001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011493001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011493001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011493002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011493002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011493002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011493003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011493003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011493003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011493004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011493004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011493004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011493006.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011493006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011493006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011493007.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011493007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011493007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011493008.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t011495001.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t011495002.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	OMA
NV2t011495002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t011495002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011495002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011495002.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t011495002.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	OMA
NV2t011495003.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t011495004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011495004.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t011497001.1	biological_process	GO:0042795	snRNA transcription by RNA polymerase II	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]	OMA
NV2t011497001.1	biological_process	GO:0042796	snRNA transcription by RNA polymerase III	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	OMA
NV2t011497001.1	cellular_component	GO:0019185	snRNA-activating protein complex	"A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788]	OMA
NV2t011497001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t011497001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t011498001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011498001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t011500001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011500001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t011500001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t011500001.1	biological_process	GO:0006970	response to osmotic stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]	OMA
NV2t011500001.1	biological_process	GO:0007006	mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011500001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t011500001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t011500001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t011500001.1	biological_process	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	OMA
NV2t011500001.1	biological_process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]	OMA
NV2t011500001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t011500001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t011500001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t011500001.1	biological_process	GO:0051093	negative regulation of developmental process	"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t011500001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t011500001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t011500001.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t011500001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t011500001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t011500001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t011500001.1	cellular_component	GO:1902562	H4 histone acetyltransferase complex	"A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086]	OMA
NV2t011500001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011500001.1	molecular_function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	OMA
NV2t011500001.1	molecular_function	GO:0008140	cAMP response element binding protein binding	"Binding to a cAMP response element binding protein (a CREB protein)." [GOC:mah]	OMA
NV2t011500001.1	molecular_function	GO:0010485	histone H4 acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48]	OMA
NV2t011500001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t011500001.1	molecular_function	GO:0035497	cAMP response element binding	"Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470]	PANTHER
NV2t011500001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t011500001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t011500001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	OMA
NV2t011501001.1	biological_process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]	OMA
NV2t011501001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t011501001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t011504001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011505001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011513001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011516001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011516001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011516001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011516002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011516003.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011516003.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011517001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t011517001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t011517001.1	biological_process	GO:0033120	positive regulation of RNA splicing	"Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah]	OMA
NV2t011517001.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t011517001.1	biological_process	GO:1903313	positive regulation of mRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t011517001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t011517001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t011517001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011517001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t011517001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t011517001.1	molecular_function	GO:0036002	pre-mRNA binding	"Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]	OMA
NV2t011517001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t011520001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011520001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t011520001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011520001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t011522001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t011522001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t011522001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011522001.1	biological_process	GO:0051640	organelle localization	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]	OMA
NV2t011522001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011522001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t011522001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t011522001.1	cellular_component	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t011522001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t011522001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011522001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011523001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t011523001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t011523001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011523001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011523001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t011523001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t011523001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011523001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011524001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011524001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t011524001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t011524001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t011524001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011524001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011526001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011528001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011528001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011528002.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011528002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011528003.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011528003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011528004.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011528004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011528005.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011528005.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t011528005.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t011528005.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t011528005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011528005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011530001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011530001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011530001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011531001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t011531001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t011532001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011532001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t011532001.1	biological_process	GO:1990115	RNA polymerase III assembly	"The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex." [GOC:rb, PMID:23459708]	PANTHER
NV2t011532001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011532001.1	cellular_component	GO:0016272	prefoldin complex	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]	OMA
NV2t011532001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t011533001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011533001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011533001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011536002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011536003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011536003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t011536004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011537001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t011538001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t011538001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011538001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011538002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t011538002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011540001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011540001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011542001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011542001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t011544001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t011544001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	OMA
NV2t011544001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	PANTHER
NV2t011544001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t011544001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t011546001.1	biological_process	GO:0006265	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	InterPro
NV2t011546001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t011546001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011548001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t011548001.1	molecular_function	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN]	PANTHER
NV2t011550001.1	cellular_component	GO:0000790	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	PANTHER
NV2t011550001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011550001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011551001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t011551001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011551002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t011551002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011552001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t011553001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t011553001.1	biological_process	GO:0006072	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t011553001.1	biological_process	GO:0006116	NADH oxidation	"A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+." [GOC:ai]	OMA
NV2t011553001.1	biological_process	GO:0006116	NADH oxidation	"A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD+." [GOC:ai]	PANTHER
NV2t011553001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t011553001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t011553001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011553001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t011553001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011553001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t011553001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t011553001.1	molecular_function	GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, PMID:28326]	InterPro
NV2t011553001.1	molecular_function	GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	"Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, PMID:28326]	OMA
NV2t011553001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t011556001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t011556001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t011556001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t011556001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t011560001.1	cellular_component	GO:0010369	chromocenter	"A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888]	PANTHER
NV2t011560001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011563001.1	molecular_function	GO:0004784	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]	OMA
NV2t011563001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011563001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t011563002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011564001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t011564001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t011564001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011564001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011565001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011565001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t011565002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011565002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t011565004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011565004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t011566001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011566001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t011566002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t011566003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011566003.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t011566004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011566004.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t011566005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011566005.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t011566006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011566006.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t011567001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t011569001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	OMA
NV2t011569001.1	molecular_function	GO:0047757	chondroitin-glucuronate 5-epimerase activity	"Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN]	PANTHER
NV2t011570001.1	biological_process	GO:0006516	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t011570002.1	biological_process	GO:0006516	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t011571001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t011571001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t011571001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t011571001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011571001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011571001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t011571001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t011572001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t011572001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011572001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	InterPro
NV2t011572001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	OMA
NV2t011573001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t011573001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011573001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011574001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t011574001.1	molecular_function	GO:0070180	large ribosomal subunit rRNA binding	"Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]	PANTHER
NV2t011575001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t011575001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t011575001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t011575001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t011575001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t011575001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t011575001.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t011575002.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t011575002.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t011578001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t011578001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	InterPro
NV2t011580001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t011580001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t011580001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t011580002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011580002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011580002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t011580002.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	PANTHER
NV2t011580002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011580003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011580003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011580003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t011580003.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	PANTHER
NV2t011580003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011580004.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011580004.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011580004.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t011580004.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	PANTHER
NV2t011580004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011581001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011583001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t011583001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t011583001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011583001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t011583001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t011584001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011584001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t011584001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t011584001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t011584001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011584001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011586001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011586001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011586001.1	molecular_function	GO:0032036	myosin heavy chain binding	"Binding to a heavy chain of a myosin complex." [GOC:mah]	PANTHER
NV2t011587001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t011587001.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	InterPro
NV2t011589001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t011589001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t011589002.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t011589002.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t011589003.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t011589003.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	OMA
NV2t011589003.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t011590001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011591001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591008.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591009.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591010.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591011.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591012.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591013.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591014.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591015.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591016.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591017.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591018.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011591019.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011592001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011592001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011592001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011592001.1	molecular_function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr]	OMA
NV2t011592001.1	molecular_function	GO:0017069	snRNA binding	"Binding to a small nuclear RNA (snRNA)." [GOC:mah]	InterPro
NV2t011592001.1	molecular_function	GO:0017069	snRNA binding	"Binding to a small nuclear RNA (snRNA)." [GOC:mah]	OMA
NV2t011592001.1	molecular_function	GO:0097322	7SK snRNA binding	"Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533]	PANTHER
NV2t011593001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t011593001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t011593001.1	biological_process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t011593001.1	cellular_component	GO:0016593	Cdc73/Paf1 complex	"A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]	InterPro
NV2t011593001.1	cellular_component	GO:0016593	Cdc73/Paf1 complex	"A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]	OMA
NV2t011593001.1	molecular_function	GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	"Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944]	OMA
NV2t011593001.1	molecular_function	GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	"Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944]	PANTHER
NV2t011595001.1	biological_process	GO:0030239	myofibril assembly	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]	OMA
NV2t011595001.1	cellular_component	GO:0001725	stress fiber	"A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381]	OMA
NV2t011595001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	OMA
NV2t011595001.1	cellular_component	GO:0030016	myofibril	"The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]	OMA
NV2t011595001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011595001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011595001.1	molecular_function	GO:0032036	myosin heavy chain binding	"Binding to a heavy chain of a myosin complex." [GOC:mah]	OMA
NV2t011595001.1	molecular_function	GO:0032036	myosin heavy chain binding	"Binding to a heavy chain of a myosin complex." [GOC:mah]	PANTHER
NV2t011597001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t011597001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t011598001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011598001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011598001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011598001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011598001.1	molecular_function	GO:0015370	solute:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai]	OMA
NV2t011602001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011602001.1	molecular_function	GO:0002161	aminoacyl-tRNA editing activity	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]	OMA
NV2t011602001.1	molecular_function	GO:0051499	D-aminoacyl-tRNA deacylase activity	"Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667]	InterPro
NV2t011602001.1	molecular_function	GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	"Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA." [PMID:14527667]	PANTHER
NV2t011602002.1	molecular_function	GO:0051499	D-aminoacyl-tRNA deacylase activity	"Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667]	InterPro
NV2t011602002.1	molecular_function	GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	"Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA." [PMID:14527667]	PANTHER
NV2t011602003.1	molecular_function	GO:0051499	D-aminoacyl-tRNA deacylase activity	"Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667]	InterPro
NV2t011602003.1	molecular_function	GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	"Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA." [PMID:14527667]	PANTHER
NV2t011606001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t011606001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t011606001.1	molecular_function	GO:0016413	O-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t011607001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011607001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t011608001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011608001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t011608001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t011608001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t011609001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t011609001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t011609001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t011610001.1	cellular_component	GO:0070876	SOSS complex	"A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501]	PANTHER
NV2t011610002.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t011610002.1	biological_process	GO:0010212	response to ionizing radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]	OMA
NV2t011610002.1	cellular_component	GO:0070876	SOSS complex	"A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501]	PANTHER
NV2t011610002.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t011610002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t011611001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t011611001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t011611001.1	biological_process	GO:0006101	citrate metabolic process	"The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	InterPro
NV2t011611001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t011611001.1	biological_process	GO:0072350	tricarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [GOC:mah]	OMA
NV2t011611001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t011611001.1	molecular_function	GO:0004108	citrate (Si)-synthase activity	"Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1]	OMA
NV2t011611001.1	molecular_function	GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	InterPro
NV2t011611002.1	biological_process	GO:0006101	citrate metabolic process	"The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	InterPro
NV2t011611002.1	molecular_function	GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	InterPro
NV2t011614001.1	molecular_function	GO:0008296	3'-5'-DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]	OMA
NV2t011614001.1	molecular_function	GO:0008296	3'-5'-DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]	PANTHER
NV2t011614001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t011615001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	PANTHER
NV2t011615001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011615002.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t011615002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t011615002.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t011615002.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t011615002.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t011615002.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	PANTHER
NV2t011615002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011616001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t011618001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t011618001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011618001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011619001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011619001.1	biological_process	GO:0072334	UDP-galactose transmembrane transport	"The process in which UDP-galactose is transported across a membrane." [GOC:mah]	PANTHER
NV2t011619001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t011619001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t011619001.1	molecular_function	GO:0005459	UDP-galactose transmembrane transporter activity	"Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011619001.1	molecular_function	GO:0005460	UDP-glucose transmembrane transporter activity	"Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011620001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011620002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011620002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011620002.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t011620002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t011621001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t011622001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t011622002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t011622002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t011622002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011622002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011622003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t011622003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011622004.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t011622004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011625002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t011625002.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t011625002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011625002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011625002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011625002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011625003.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t011625003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011626001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011626001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011626001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t011626002.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t011626002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t011626002.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t011626002.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t011626002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011626002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011626002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011626002.1	molecular_function	GO:0031624	ubiquitin conjugating enzyme binding	"Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]	OMA
NV2t011626002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t011626002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t011627001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t011627001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t011627001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t011627001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t011627001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	PANTHER
NV2t011627001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t011627001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t011627002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t011627002.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	PANTHER
NV2t011629001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t011629001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t011629001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011629001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t011629001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011629002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t011629002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011630001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t011630001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t011631001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011631001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t011631001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011631002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011631002.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t011631002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011631003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011631003.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t011631003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011632001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t011632001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t011632001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t011632001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t011632001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t011633001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t011634001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	InterPro
NV2t011634002.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	InterPro
NV2t011634003.1	biological_process	GO:0010976	positive regulation of neuron projection development	"Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t011634003.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	InterPro
NV2t011634003.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t011634003.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t011636001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t011636001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t011636001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t011636001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t011637001.1	biological_process	GO:0007129	homologous chromosome pairing at meiosis	"The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]	OMA
NV2t011637001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t011637001.1	cellular_component	GO:0000794	condensed nuclear chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh]	OMA
NV2t011637001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t011637001.1	cellular_component	GO:0120231	DNA recombinase auxiliary factor complex	"A protein complex that binds to a recombinase and incrseases its activity." [PMID:32414915]	PANTHER
NV2t011637001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t011637001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011637001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t011639001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011639001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011639001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t011640001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011640001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011642001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011642001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t011642001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011642001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t011642002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011642002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011642003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011642003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011643001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011643001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t011643001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t011643001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011643001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011643001.1	molecular_function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]	OMA
NV2t011643001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011643001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011643002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011643002.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t011643002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011643002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011643003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011643003.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t011643003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011643003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011645001.1	biological_process	GO:0032101	regulation of response to external stimulus	"Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t011645001.1	biological_process	GO:0050878	regulation of body fluid levels	"Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t011645001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t011645001.1	biological_process	GO:0090303	positive regulation of wound healing	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]	OMA
NV2t011645001.1	molecular_function	GO:0047710	bis(5'-adenosyl)-triphosphatase activity	"Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+." [EC:3.6.1.29, RHEA:13893]	OMA
NV2t011647001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011647001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011647002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011647003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011647003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011647004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011647005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011647005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011649001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011649001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011649002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011649002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011649003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011649003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t011651001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011651001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t011651001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t011651001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011651001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t011653001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011653001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t011654001.1	biological_process	GO:0032324	molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]	OMA
NV2t011654001.1	biological_process	GO:0043545	molybdopterin cofactor metabolic process	"The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t011654001.1	molecular_function	GO:0008265	Mo-molybdopterin cofactor sulfurase activity	"Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764]	InterPro
NV2t011654001.1	molecular_function	GO:0008265	Mo-molybdopterin cofactor sulfurase activity	"Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764]	OMA
NV2t011654001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t011654001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t011654001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t011654002.1	biological_process	GO:0043545	molybdopterin cofactor metabolic process	"The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t011654002.1	molecular_function	GO:0008265	Mo-molybdopterin cofactor sulfurase activity	"Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764]	InterPro
NV2t011654002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t011654003.1	biological_process	GO:0043545	molybdopterin cofactor metabolic process	"The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t011654003.1	molecular_function	GO:0008265	Mo-molybdopterin cofactor sulfurase activity	"Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764]	InterPro
NV2t011654003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t011654004.1	biological_process	GO:0043545	molybdopterin cofactor metabolic process	"The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t011654005.1	biological_process	GO:0043545	molybdopterin cofactor metabolic process	"The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t011654006.1	biological_process	GO:0043545	molybdopterin cofactor metabolic process	"The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t011654007.1	biological_process	GO:0043545	molybdopterin cofactor metabolic process	"The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	PANTHER
NV2t011655001.1	biological_process	GO:0008585	female gonad development	"The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t011655001.1	biological_process	GO:0033260	nuclear DNA replication	"The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t011655001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	OMA
NV2t011655001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t011655001.1	biological_process	GO:0044773	mitotic DNA damage checkpoint signaling	"A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]	OMA
NV2t011655001.1	biological_process	GO:0048477	oogenesis	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]	OMA
NV2t011655001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	OMA
NV2t011655001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t011655001.1	biological_process	GO:0048511	rhythmic process	"Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]	OMA
NV2t011655001.1	biological_process	GO:0048589	developmental growth	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]	OMA
NV2t011655001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t011655001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t011655001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011655001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011655001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011655002.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t011655002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011657001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t011658001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011658001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t011661001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011661001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t011661001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t011662001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011662001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t011662001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t011662001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t011662001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011662001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011663001.1	biological_process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	OMA
NV2t011663001.1	biological_process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF]	PANTHER
NV2t011663001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011664001.1	biological_process	GO:0045540	regulation of cholesterol biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]	PANTHER
NV2t011664001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011665001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t011665001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011666001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t011666001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t011666001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011666001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t011666001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t011666001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t011668001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t011668001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011668001.1	molecular_function	GO:0015645	fatty acid ligase activity	"Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [GOC:cjk, GOC:mah]	OMA
NV2t011668001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t011668001.1	molecular_function	GO:0031956	medium-chain fatty acid-CoA ligase activity	"Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:48340]	PANTHER
NV2t011670001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011670001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011670001.1	biological_process	GO:0051046	regulation of secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]	PANTHER
NV2t011670002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011670002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011670002.1	biological_process	GO:0051046	regulation of secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]	PANTHER
NV2t011670003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011670003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011670003.1	biological_process	GO:0051046	regulation of secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]	PANTHER
NV2t011670004.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011670004.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011670004.1	biological_process	GO:0051046	regulation of secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]	PANTHER
NV2t011670005.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011670005.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011670005.1	biological_process	GO:0051046	regulation of secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]	PANTHER
NV2t011670006.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011670006.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t011670006.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011670006.1	biological_process	GO:0051046	regulation of secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]	PANTHER
NV2t011670006.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	OMA
NV2t011670006.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t011672001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011672001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011673001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011673001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t011673001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011675001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011675001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011680001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t011680001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t011680001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t011681001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t011681001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t011681001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t011681001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t011681001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t011681001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t011682001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t011682001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t011682001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t011682001.1	biological_process	GO:0042773	ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]	InterPro
NV2t011682001.1	biological_process	GO:0045333	cellular respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]	PANTHER
NV2t011682001.1	biological_process	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	OMA
NV2t011682001.1	biological_process	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	OMA
NV2t011682001.1	biological_process	GO:0072593	reactive oxygen species metabolic process	"The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah]	OMA
NV2t011682001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t011682001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t011682001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t011682001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t011682001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011682001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t011682001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t011682001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t011683001.1	biological_process	GO:0003254	regulation of membrane depolarization	"Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]	OMA
NV2t011683001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	OMA
NV2t011683001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011683001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t011683001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011683001.1	cellular_component	GO:0098855	HCN channel complex	"A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart." [PMID:20829353]	PANTHER
NV2t011683001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011684001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	InterPro
NV2t011684002.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	InterPro
NV2t011684003.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	InterPro
NV2t011684004.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	InterPro
NV2t011685001.1	biological_process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]	OMA
NV2t011685001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t011685001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	PANTHER
NV2t011686001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011686001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011686001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011686001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011686001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011686001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011687001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011687001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t011689001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t011689001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t011689001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t011689001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t011689001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t011689001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t011689001.1	cellular_component	GO:0005662	DNA replication factor A complex	"A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]	OMA
NV2t011689001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t011689001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t011689001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t011689001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t011690001.1	biological_process	GO:0006574	valine catabolic process	"The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]	PANTHER
NV2t011690002.1	biological_process	GO:0006574	valine catabolic process	"The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]	PANTHER
NV2t011690003.1	biological_process	GO:0006574	valine catabolic process	"The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]	PANTHER
NV2t011692001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011692002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011692003.1	biological_process	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	OMA
NV2t011692003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011692003.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t011692003.1	biological_process	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t011692003.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t011692003.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	OMA
NV2t011693001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t011693001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t011693002.1	biological_process	GO:0045945	positive regulation of transcription by RNA polymerase III	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011693002.1	cellular_component	GO:0008023	transcription elongation factor complex	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]	InterPro
NV2t011693003.1	biological_process	GO:0045945	positive regulation of transcription by RNA polymerase III	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011693003.1	cellular_component	GO:0008023	transcription elongation factor complex	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]	InterPro
NV2t011693004.1	biological_process	GO:0045945	positive regulation of transcription by RNA polymerase III	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011693004.1	cellular_component	GO:0008023	transcription elongation factor complex	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]	InterPro
NV2t011695001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t011695001.1	biological_process	GO:0006419	alanyl-tRNA aminoacylation	"The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t011695001.1	biological_process	GO:0006450	regulation of translational fidelity	"Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]	PANTHER
NV2t011695001.1	biological_process	GO:0043039	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	InterPro
NV2t011695001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t011695001.1	molecular_function	GO:0002161	aminoacyl-tRNA editing activity	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]	OMA
NV2t011695001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011695001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t011695001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011696001.1	biological_process	GO:0000076	DNA replication checkpoint signaling	"A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518]	OMA
NV2t011696001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t011696001.1	biological_process	GO:0042752	regulation of circadian rhythm	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]	OMA
NV2t011696001.1	biological_process	GO:0043111	replication fork arrest	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected." [GOC:jl, GOC:pr, PMID:14645529]	OMA
NV2t011696001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	OMA
NV2t011696001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t011696001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	OMA
NV2t011696001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t011696001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t011696002.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t011698001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t011698001.1	biological_process	GO:0044458	motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]	OMA
NV2t011698001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011698001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t011698001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	OMA
NV2t011698001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t011698001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t011698002.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t011699001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t011699001.1	biological_process	GO:0007023	post-chaperonin tubulin folding pathway	"Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094]	InterPro
NV2t011699001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t011699001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011699001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	InterPro
NV2t011699001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t011701001.1	biological_process	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t011701001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t011701001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t011704001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t011704001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t011704001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t011704001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t011704001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t011704001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t011704001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t011704001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t011704001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t011705001.1	biological_process	GO:0006574	valine catabolic process	"The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]	OMA
NV2t011705001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011705001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011705001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t011705001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t011705001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t011705001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t011705001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t011709001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011711001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t011711001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011711001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t011711001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t011711001.1	biological_process	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	OMA
NV2t011711001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t011711001.1	biological_process	GO:0051179	localization	"Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos]	OMA
NV2t011711001.1	biological_process	GO:0051256	mitotic spindle midzone assembly	"The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120]	OMA
NV2t011711001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011711001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t011711001.1	cellular_component	GO:0032154	cleavage furrow	"The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409]	OMA
NV2t011711001.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	OMA
NV2t011711001.1	cellular_component	GO:0097149	centralspindlin complex	"A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals)." [GOC:ans, PMID:11782313, PMID:16236794]	OMA
NV2t011711001.1	cellular_component	GO:0097149	centralspindlin complex	"A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals)." [GOC:ans, PMID:11782313, PMID:16236794]	PANTHER
NV2t011711001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t011716001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011716001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t011727002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t011727002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t011727003.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t011727003.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t011728001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t011731001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t011731001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t011731001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t011731001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t011733001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t011733001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t011733001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t011733001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t011734001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t011734001.1	biological_process	GO:0106034	protein maturation by [2Fe-2S] cluster transfer	"The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]	PANTHER
NV2t011734001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011734001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t011734001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t011735001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t011735001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t011736001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	InterPro
NV2t011736001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t011736001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t011736001.1	molecular_function	GO:0003785	actin monomer binding	"Binding to monomeric actin, also known as G-actin." [GOC:ai]	OMA
NV2t011739001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011739001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t011739001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011739001.1	molecular_function	GO:0008349	MAP kinase kinase kinase kinase activity	"Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]	InterPro
NV2t011739002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011739002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t011739002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011739002.1	molecular_function	GO:0008349	MAP kinase kinase kinase kinase activity	"Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]	InterPro
NV2t011739003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011739003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t011739003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011739003.1	molecular_function	GO:0008349	MAP kinase kinase kinase kinase activity	"Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]	InterPro
NV2t011739004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011739004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t011739004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011739004.1	molecular_function	GO:0008349	MAP kinase kinase kinase kinase activity	"Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]	InterPro
NV2t011739005.1	biological_process	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	OMA
NV2t011739005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011739005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t011739005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t011739005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011739005.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t011739005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011739005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011739005.1	molecular_function	GO:0008349	MAP kinase kinase kinase kinase activity	"Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]	InterPro
NV2t011742001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t011742001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011742001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t011742001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t011742001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t011742001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t011742001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t011742001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t011743001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t011743001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011743001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t011743001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t011743001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t011743001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t011743001.1	molecular_function	GO:0140104	molecular carrier activity	"Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t011746001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t011746001.1	molecular_function	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]	InterPro
NV2t011746001.1	molecular_function	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]	PANTHER
NV2t011746002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t011746002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t011746002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t011746002.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t011746002.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t011746002.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t011746002.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t011746002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011746002.1	molecular_function	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]	InterPro
NV2t011746002.1	molecular_function	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]	PANTHER
NV2t011747001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t011747001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011747002.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t011747002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011747003.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t011747003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011747004.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t011747004.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011747005.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t011747005.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t011748001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t011748001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t011748001.1	biological_process	GO:0070861	regulation of protein exit from endoplasmic reticulum	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t011748001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t011748001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t011748001.1	biological_process	GO:0090317	negative regulation of intracellular protein transport	"Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t011748001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t011748001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t011748001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011748001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011748001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t011749001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t011749001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t011749001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t011749002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t011749003.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t011750001.1	cellular_component	GO:1990726	Lsm1-7-Pat1 complex	"A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]	PANTHER
NV2t011750001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t011751001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t011751001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t011753001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t011754001.1	biological_process	GO:0090305	obsolete nucleic acid phosphodiester bond hydrolysis	"OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	InterPro
NV2t011754001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t011756001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t011756001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t011756001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t011756001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011756001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011756001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t011756001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t011756001.1	molecular_function	GO:0016018	cyclosporin A binding	"Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb]	OMA
NV2t011757001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t011757001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t011757001.1	biological_process	GO:0007033	vacuole organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]	InterPro
NV2t011757001.1	biological_process	GO:0007033	vacuole organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]	OMA
NV2t011757001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t011757001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t011757001.1	biological_process	GO:0042144	vacuole fusion, non-autophagic	"The fusion of two vacuole membranes to form a single vacuole." [GOC:jl]	PANTHER
NV2t011757001.1	biological_process	GO:0048284	organelle fusion	"The creation of a single organelle from two or more organelles." [GOC:jid]	OMA
NV2t011757001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t011757001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t011757001.1	cellular_component	GO:0030897	HOPS complex	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]	OMA
NV2t011757001.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	OMA
NV2t011757001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t011757001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011758001.1	biological_process	GO:0048843	negative regulation of axon extension involved in axon guidance	"Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]	PANTHER
NV2t011758001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011758001.1	molecular_function	GO:0030215	semaphorin receptor binding	"Binding to a semaphorin receptor." [GOC:ceb, PMID:12001990]	OMA
NV2t011759001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t011760001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t011760001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t011761001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t011761001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t011761001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t011761001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t011761001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t011761001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t011761001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t011761001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t011761001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t011762001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011762001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t011762001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011762001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t011762001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011764001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011764001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011764001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t011764001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011764001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011764001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011764002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011764002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011764002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011764002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011764003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011764003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011764003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011764003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011764004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t011764004.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011764004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011764004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011765001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	InterPro
NV2t011765001.1	cellular_component	GO:0070419	nonhomologous end joining complex	"A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628]	PANTHER
NV2t011770001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011770001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t011770001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t011770001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	PANTHER
NV2t011770002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t011770002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t011770002.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	PANTHER
NV2t011771001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011771002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011771003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011774001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t011774001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011774001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t011775001.1	biological_process	GO:0045494	photoreceptor cell maintenance	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]	OMA
NV2t011775001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t011775001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t011775001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t011775001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t011775001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t011775001.1	cellular_component	GO:0032391	photoreceptor connecting cilium	"The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone." [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680]	OMA
NV2t011775001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011775001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t011775001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t011776001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t011776001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t011776001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t011776003.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t011777001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t011777001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t011777001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t011777001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t011777001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011777001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	InterPro
NV2t011777001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t011777001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t011777001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t011777001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t011777001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t011777001.1	molecular_function	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	OMA
NV2t011779001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t011779001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t011779001.1	biological_process	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	OMA
NV2t011779001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t011779001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t011779001.1	biological_process	GO:0002699	positive regulation of immune effector process	"Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]	OMA
NV2t011779001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t011779001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t011779001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t011779001.1	biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]	OMA
NV2t011779001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t011779001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t011779001.1	biological_process	GO:0009409	response to cold	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]	OMA
NV2t011779001.1	biological_process	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	OMA
NV2t011779001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t011779001.1	biological_process	GO:0016444	somatic cell DNA recombination	"Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]	OMA
NV2t011779001.1	biological_process	GO:0022409	positive regulation of cell-cell adhesion	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t011779001.1	biological_process	GO:0034514	mitochondrial unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004]	OMA
NV2t011779001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t011779001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t011779001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t011779001.1	biological_process	GO:0044743	protein transmembrane import into intracellular organelle	"The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]	OMA
NV2t011779001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t011779001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t011779001.1	biological_process	GO:0051702	biological process involved in interaction with symbiont	"An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]	OMA
NV2t011779001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t011779001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t011779001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t011779001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t011779001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t011779001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011779001.1	cellular_component	GO:0005905	clathrin-coated pit	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]	OMA
NV2t011779001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t011779001.1	cellular_component	GO:0030135	coated vesicle	"Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]	OMA
NV2t011779001.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	OMA
NV2t011779001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t011779001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t011779001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t011779001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t011779001.1	molecular_function	GO:0001530	lipopolysaccharide binding	"Binding to a lipopolysaccharide." [PMID:11079463]	OMA
NV2t011779001.1	molecular_function	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	OMA
NV2t011779001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t011779001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011779001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011779001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t011779001.1	molecular_function	GO:0034185	apolipoprotein binding	"Binding to an apolipoprotein, the protein component of a lipoprotein complex." [GOC:BHF, GOC:rl]	OMA
NV2t011779001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t011779001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t011779001.1	molecular_function	GO:0071813	lipoprotein particle binding	"Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:BHF, GOC:mah]	OMA
NV2t011779001.1	molecular_function	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	OMA
NV2t011779001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t011782001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	PANTHER
NV2t011783001.1	biological_process	GO:0071985	multivesicular body sorting pathway	"A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]	InterPro
NV2t011783001.1	biological_process	GO:0071985	multivesicular body sorting pathway	"A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]	OMA
NV2t011783001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t011783001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t011783001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t011786001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011786001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t011786001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t011786001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t011786001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t011786001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011790001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011790001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011790002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011790002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011790003.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011790003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011790004.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t011791001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011791001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011791001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t011791001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011791001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t011791001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t011791002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t011791002.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011791002.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t011794001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011794001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011794001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t011795001.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	OMA
NV2t011795001.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	OMA
NV2t011795001.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	PANTHER
NV2t011795001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011795001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011795001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t011795002.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	PANTHER
NV2t011795002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011795003.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	PANTHER
NV2t011795003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011796001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t011796001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t011797001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011797001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011798001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t011798001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011799001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011799001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011802001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	PANTHER
NV2t011802002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011802003.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	PANTHER
NV2t011803001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011803002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011803002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011803002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011803002.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t011804001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011804001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011804001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011804001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t011804001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011805001.1	molecular_function	GO:0051184	obsolete cofactor transmembrane transporter activity	"OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]	PANTHER
NV2t011806001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011806001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	OMA
NV2t011808001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011809001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t011810001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011810001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t011810001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t011810001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t011810001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t011810001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t011810001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t011810001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t011810001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t011810001.1	biological_process	GO:0043524	negative regulation of neuron apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t011810001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	OMA
NV2t011810001.1	biological_process	GO:0051149	positive regulation of muscle cell differentiation	"Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]	OMA
NV2t011810001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t011810001.1	biological_process	GO:0055082	intracellular chemical homeostasis	"A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." [GOC:isa_complete, GOC:jid]	OMA
NV2t011810001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	OMA
NV2t011810001.1	biological_process	GO:1903202	obsolete negative regulation of oxidative stress-induced cell death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	OMA
NV2t011810001.1	biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t011810001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t011810001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t011810001.1	molecular_function	GO:0004784	superoxide dismutase activity	"Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]	OMA
NV2t011810001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t011810001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011810001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t011811001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t011811001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	InterPro
NV2t011811001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	OMA
NV2t011812001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t011812001.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t011813001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t011813001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011813001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011814001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011814001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t011815001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t011828001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011828001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011828001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011828001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t011828002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011828002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011828003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011828003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t011830001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	PANTHER
NV2t011831001.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t011831001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t011831001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t011831001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t011831001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	OMA
NV2t011831001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t011831002.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t011831002.1	molecular_function	GO:0016929	deSUMOylase activity	"An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250, PMID:23746258]	PANTHER
NV2t011833001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011833002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t011834001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t011834001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t011834001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t011834001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t011834001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	PANTHER
NV2t011834001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t011834001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011836001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t011838001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t011838001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011839001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t011839001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t011839001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011839002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t011839002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011839003.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t011839003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011839004.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t011839004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011842001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t011844001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t011846001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011846001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t011846002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011846003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011846004.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011846005.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t011847001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t011847001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t011847002.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t011847002.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t011847003.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t011847003.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t011847004.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t011847004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011847004.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t011847004.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t011847004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011847004.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t011847004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t011847004.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t011847004.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t011847004.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t011847004.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t011849001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t011849001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t011849001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	InterPro
NV2t011849001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	OMA
NV2t011849001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t011849001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011850001.1	molecular_function	GO:0071617	lysophospholipid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]	PANTHER
NV2t011851001.1	molecular_function	GO:0071617	lysophospholipid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]	PANTHER
NV2t011853001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011853001.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t011855001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t011860001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t011860001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t011860001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t011860001.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	PANTHER
NV2t011860001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	InterPro
NV2t011860001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t011860001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t011860001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t011862001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011863001.1	biological_process	GO:0032970	regulation of actin filament-based process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]	OMA
NV2t011863001.1	biological_process	GO:0032970	regulation of actin filament-based process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]	PANTHER
NV2t011864001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t011864001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t011864001.1	biological_process	GO:0006433	prolyl-tRNA aminoacylation	"The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA." [GOC:mah, ISBN:0716730510]	InterPro
NV2t011864001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011864001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t011864001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	PANTHER
NV2t011864001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t011864001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011866001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011866001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011866001.1	molecular_function	GO:0004177	aminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]	InterPro
NV2t011866001.1	molecular_function	GO:0004177	aminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]	OMA
NV2t011866001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011866001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011866001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t011870001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011870001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t011872001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011872001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t011872001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t011872002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011872002.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t011874001.1	biological_process	GO:0032273	positive regulation of protein polymerization	"Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	OMA
NV2t011874001.1	biological_process	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	InterPro
NV2t011874001.1	biological_process	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	PANTHER
NV2t011874001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t011874002.1	biological_process	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	InterPro
NV2t011874002.1	biological_process	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	PANTHER
NV2t011874003.1	biological_process	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	InterPro
NV2t011874003.1	biological_process	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	PANTHER
NV2t011875001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t011875001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011875001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t011876001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011876002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011878001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t011878002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t011878003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t011878004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t011878005.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t011879001.1	biological_process	GO:0010638	positive regulation of organelle organization	"Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	OMA
NV2t011879001.1	biological_process	GO:0043954	cellular component maintenance	"The organization process that preserves a cellular component in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011879001.1	biological_process	GO:0071786	endoplasmic reticulum tubular network organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	OMA
NV2t011879001.1	biological_process	GO:0071786	endoplasmic reticulum tubular network organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	PANTHER
NV2t011879001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t011879001.1	cellular_component	GO:0071782	endoplasmic reticulum tubular network	"A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	OMA
NV2t011879001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t011882001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011882001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t011882001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t011884001.1	molecular_function	GO:0016866	intramolecular transferase activity	"Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t011884001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t011884001.1	molecular_function	GO:0031419	cobalamin binding	"Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]	InterPro
NV2t011884001.1	molecular_function	GO:0031419	cobalamin binding	"Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]	PANTHER
NV2t011884001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t011884001.1	molecular_function	GO:0046906	tetrapyrrole binding	"Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [GOC:curators, ISBN:0198506732]	OMA
NV2t011891001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011891001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	InterPro
NV2t011891001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t011891001.1	biological_process	GO:0031324	negative regulation of cellular metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t011891001.1	biological_process	GO:0035303	regulation of dephosphorylation	"Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]	OMA
NV2t011891001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t011891001.1	biological_process	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t011891001.1	biological_process	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t011891001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011891001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t011891001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t011891001.1	molecular_function	GO:0051721	protein phosphatase 2A binding	"Binding to protein phosphatase 2A." [GOC:ai]	PANTHER
NV2t011893001.1	biological_process	GO:1904960	positive regulation of cytochrome-c oxidase activity	"Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017]	OMA
NV2t011893001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t011893001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t011893001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t011893001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t011894001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t011895001.1	biological_process	GO:0010043	response to zinc ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]	OMA
NV2t011895001.1	biological_process	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t011895001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t011895001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011895001.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t011895001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011895001.1	molecular_function	GO:0005385	zinc ion transmembrane transporter activity	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t011900001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011900001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011902001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	PANTHER
NV2t011903001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t011903001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904007.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904008.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904009.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904010.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904012.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904013.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904014.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904015.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011904016.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t011906001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011906001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t011908001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011908002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011908003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011908004.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t011908004.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t011909001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t011909001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t011909001.1	biological_process	GO:0007229	integrin-mediated signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t011909001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t011909001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t011909001.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	OMA
NV2t011909001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t011909001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011909001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	InterPro
NV2t011909001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	OMA
NV2t011909001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t011909001.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t011910001.1	biological_process	GO:0085020	protein K6-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]	PANTHER
NV2t011910001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011913001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t011913001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t011913001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011913001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011913001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t011913001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t011913001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t011913001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t011913001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t011913001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t011914001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011914001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011914001.1	molecular_function	GO:0005215	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	PANTHER
NV2t011914001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011916001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t011916001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011916002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011916003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011917001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t011917001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t011917001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011917001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011917001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t011917001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t011917001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t011917001.1	molecular_function	GO:0004890	GABA-A receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]	OMA
NV2t011917001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t011917001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t011917001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t011920001.1	molecular_function	GO:0160107	tRNA (adenine(58)-N1)-methyltransferase activity	"Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.220]	InterPro
NV2t011921001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t011921001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t011921001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t011921001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t011921001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t011921001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t011921001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t011921001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t011921001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011922001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011922001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011922001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t011922001.1	molecular_function	GO:0042626	ATPase-coupled transmembrane transporter activity	"Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t011922001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t011922001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t011923001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t011924001.1	molecular_function	GO:0017150	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H." [PMID:11983710, PMID:22123979]	PANTHER
NV2t011924001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011924001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t011924002.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t011924002.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t011924002.1	molecular_function	GO:0017150	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H." [PMID:11983710, PMID:22123979]	PANTHER
NV2t011924002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011924002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t011924002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t011924002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t011924002.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t011924003.1	molecular_function	GO:0017150	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H." [PMID:11983710, PMID:22123979]	PANTHER
NV2t011924003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t011924004.1	molecular_function	GO:0017150	tRNA dihydrouridine synthase activity	"Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H." [PMID:11983710, PMID:22123979]	PANTHER
NV2t011924004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t011924004.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t011925001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t011925001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t011925001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t011925001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011925001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011927001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t011927001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t011927001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t011927001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t011927001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	PANTHER
NV2t011928001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t011928001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011929001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t011929001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	InterPro
NV2t011929001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t011929001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	PANTHER
NV2t011929001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t011929001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t011929001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	OMA
NV2t011929001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t011929001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011929001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t011929001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t011929001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t011930001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t011930001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011930001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011930001.1	molecular_function	GO:0005242	inward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]	OMA
NV2t011930002.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t011930002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011931001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t011931001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011931001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011931001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t011931001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t011931001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t011931002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t011931002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t011931002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t011931003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t011931003.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t011932001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t011932001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t011932001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011932001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t011932001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t011932001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t011932002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t011932002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t011932003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t011932003.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t011933001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t011933001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011933002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t011933002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t011933002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t011934001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t011934001.1	cellular_component	GO:0031227	obsolete intrinsic component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t011934002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t011934002.1	cellular_component	GO:0031227	obsolete intrinsic component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t011934003.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t011934003.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t011934003.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t011934003.1	cellular_component	GO:0031227	obsolete intrinsic component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t011934003.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t011935001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t011935001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t011936001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t011936001.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	OMA
NV2t011936001.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	PANTHER
NV2t011936001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t011936001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t011937001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t011937001.1	biological_process	GO:0015937	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	InterPro
NV2t011937001.1	biological_process	GO:0015937	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	PANTHER
NV2t011937001.1	biological_process	GO:0034030	ribonucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t011937001.1	biological_process	GO:0034033	purine nucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t011937001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011937001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t011937001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t011940001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t011940001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t011940001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t011940001.1	biological_process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]	OMA
NV2t011940001.1	biological_process	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871]	OMA
NV2t011940001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011940001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011940001.1	molecular_function	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	OMA
NV2t011940002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t011941001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t011941001.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t011941002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t011941002.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t011941003.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t011941003.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t011941004.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t011941004.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t011941005.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t011941005.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t011941006.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t011941006.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t011946001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011946001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011946001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011946002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011946002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011946002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011946003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t011946003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011946003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011949001.1	biological_process	GO:2000812	regulation of barbed-end actin filament capping	"Any process that modulates the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF]	PANTHER
NV2t011949001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011951001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t011951001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t011951001.1	biological_process	GO:0030834	regulation of actin filament depolymerization	"Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t011951001.1	biological_process	GO:2000812	regulation of barbed-end actin filament capping	"Any process that modulates the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF]	PANTHER
NV2t011951001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011951001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011951001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011951001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t011952001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011952001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t011952001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t011952001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t011954001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t011954001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011954001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t011955001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011955001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t011955001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011955002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011955002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t011956001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t011956001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t011956001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t011958001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t011960001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011960001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011961001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t011961001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t011961001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011961001.1	molecular_function	GO:0004896	cytokine receptor activity	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]	OMA
NV2t011961001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011961001.1	molecular_function	GO:0019955	cytokine binding	"Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]	OMA
NV2t011962001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t011962001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011969001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t011971001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t011973001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011976001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t011976001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t011980001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t011980001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t011980001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t011980001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	PANTHER
NV2t011980001.1	biological_process	GO:0007080	mitotic metaphase chromosome alignment	"A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [ISBN:0815316194]	OMA
NV2t011980001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	OMA
NV2t011980001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t011980001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011980001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t011980001.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	OMA
NV2t011980001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t011980001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t011980001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t011980001.1	molecular_function	GO:0030507	spectrin binding	"Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732]	OMA
NV2t011980001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t011981001.1	biological_process	GO:0034613	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t011982001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	PANTHER
NV2t011982001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t011982001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t011982001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t011982001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t011982001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t011982001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t011982001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t011983001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011983001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t011983001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t011983001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t011983001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t011985001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011986001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t011986001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	PANTHER
NV2t011986001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t011986001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011986001.1	molecular_function	GO:0019136	deoxynucleoside kinase activity	"Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]	OMA
NV2t011987001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t011988001.1	biological_process	GO:0006858	extracellular transport	"The transport of substances that occurs outside cells." [GOC:go_curators]	OMA
NV2t011988001.1	biological_process	GO:0007288	sperm axoneme assembly	"The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t011988001.1	biological_process	GO:0046847	filopodium assembly	"The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790]	OMA
NV2t011988001.1	biological_process	GO:0099111	microtubule-based transport	"A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t011988001.1	biological_process	GO:1990138	neuron projection extension	"Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009]	OMA
NV2t011988001.1	cellular_component	GO:0001669	acrosomal vesicle	"A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]	OMA
NV2t011988001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t011988001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t011988001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t011988001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t011988001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t011988001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t011989001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t011989002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t011990001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t011990002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t011991001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t011991001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t011991001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t011991001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t011991001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t011991001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	InterPro
NV2t011991001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	PANTHER
NV2t011991001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t011991001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t011993001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t011993001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t011993001.1	biological_process	GO:0006422	aspartyl-tRNA aminoacylation	"The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA." [GOC:mah, ISBN:0716730510]	InterPro
NV2t011993001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t011993001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t011993001.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	PANTHER
NV2t011993001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t011993001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t011993001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t011993001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t011996001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t011998001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t011998001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	InterPro
NV2t011998001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t011998001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t011999001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t011999001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012001001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t012001001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t012001001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t012001001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t012001001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012001001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012004001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012004001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012004001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012004001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012004001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012007001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012007001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012007001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012007001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012007001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012008001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012008001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012008001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012011001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012011001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012011001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012012001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012012001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t012012001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012012001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012012001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012012001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012012001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t012014001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t012014001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t012014001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t012014001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t012014001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t012014001.1	biological_process	GO:0030865	cortical cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t012014001.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	OMA
NV2t012014001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	OMA
NV2t012014001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t012014001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012014001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t012014001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t012014001.1	cellular_component	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t012014001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012014001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012014001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012014001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012014001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t012014002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t012014002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012015001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t012015001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012015001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t012015001.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012015001.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t012015001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012015001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012015001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012015002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012015002.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012015002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012015002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012015003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012015003.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012015003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012015003.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012015007.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012015007.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012015007.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012015007.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012015008.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012015008.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012015008.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012015008.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012016001.1	molecular_function	GO:0048018	receptor ligand activity	"The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]	PANTHER
NV2t012019001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t012019001.1	biological_process	GO:0060285	cilium-dependent cell motility	"Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]	OMA
NV2t012019001.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t012019001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t012019001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012019001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012019001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012019001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t012019001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t012019002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012019002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012019002.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t012019003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012019003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012019003.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t012020001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t012020001.1	biological_process	GO:0060285	cilium-dependent cell motility	"Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]	OMA
NV2t012020001.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t012020001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t012020001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t012020001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t012020001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t012020001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t012023001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012023001.1	biological_process	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [GOC:mah]	PANTHER
NV2t012023001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t012023001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012023001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012023001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t012023001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t012023001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t012024001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	InterPro
NV2t012024001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t012027001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t012027001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012027001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t012027001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t012027001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t012027001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t012028002.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t012028002.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t012028002.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t012028002.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t012028002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t012028002.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t012028002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012028002.1	cellular_component	GO:0071261	Ssh1 translocon complex	"A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences." [GOC:mah, PMID:12134063, PMID:8612571]	PANTHER
NV2t012028002.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t012028002.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t012028002.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t012028002.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t012028002.1	molecular_function	GO:0022884	macromolecule transmembrane transporter activity	"Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t012028002.1	molecular_function	GO:0140318	protein transporter activity	"Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]	OMA
NV2t012029001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012029001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012029001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	PANTHER
NV2t012031001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012031001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012032001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t012033003.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t012033004.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t012033005.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t012036001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012036001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t012036001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t012037001.1	biological_process	GO:0032467	positive regulation of cytokinesis	"Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]	InterPro
NV2t012037001.1	biological_process	GO:0032467	positive regulation of cytokinesis	"Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]	OMA
NV2t012037001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t012037001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t012037001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t012037002.1	biological_process	GO:0032467	positive regulation of cytokinesis	"Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]	InterPro
NV2t012037003.1	biological_process	GO:0032467	positive regulation of cytokinesis	"Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]	InterPro
NV2t012037004.1	biological_process	GO:0032467	positive regulation of cytokinesis	"Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah]	InterPro
NV2t012038001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012038002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012038003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012038004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012038005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012038005.1	biological_process	GO:0008286	insulin receptor signaling pathway	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]	OMA
NV2t012038005.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t012038005.1	biological_process	GO:0046627	negative regulation of insulin receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]	OMA
NV2t012038005.1	molecular_function	GO:0005158	insulin receptor binding	"Binding to an insulin receptor." [GOC:ai]	OMA
NV2t012039001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t012039001.1	biological_process	GO:0031179	peptide modification	"The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah]	InterPro
NV2t012039001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012039002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t012039002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t012039002.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t012039002.1	biological_process	GO:0031179	peptide modification	"The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah]	InterPro
NV2t012039002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012039002.1	biological_process	GO:1905957	regulation of cellular response to alcohol	"Any process that modulates the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723]	OMA
NV2t012039002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012039002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012039002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012039002.1	cellular_component	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	OMA
NV2t012039002.1	molecular_function	GO:0010314	phosphatidylinositol-5-phosphate binding	"Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators]	OMA
NV2t012039002.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	OMA
NV2t012039002.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	OMA
NV2t012041001.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	InterPro
NV2t012041001.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	OMA
NV2t012041001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t012041001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t012041001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t012042001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t012042001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t012042001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t012042001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	PANTHER
NV2t012042001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t012042001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t012043001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	OMA
NV2t012043001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t012043001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t012043001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012046001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012047001.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	PANTHER
NV2t012047001.1	cellular_component	GO:0030991	intraciliary transport particle A	"The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]	InterPro
NV2t012047002.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	PANTHER
NV2t012047002.1	cellular_component	GO:0030991	intraciliary transport particle A	"The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]	InterPro
NV2t012047003.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	PANTHER
NV2t012047003.1	cellular_component	GO:0030991	intraciliary transport particle A	"The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]	InterPro
NV2t012047004.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	PANTHER
NV2t012047004.1	cellular_component	GO:0030991	intraciliary transport particle A	"The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]	InterPro
NV2t012047005.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	PANTHER
NV2t012047005.1	cellular_component	GO:0030991	intraciliary transport particle A	"The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]	InterPro
NV2t012047005.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t012048001.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	InterPro
NV2t012048002.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	InterPro
NV2t012049001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t012050001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t012052001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012052001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t012052001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012058001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t012058001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	PANTHER
NV2t012058001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	InterPro
NV2t012058001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t012061001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t012061001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t012061001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t012061002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t012061002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t012061003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t012061003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t012061004.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t012061004.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t012062001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t012062001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t012062001.1	molecular_function	GO:0000702	oxidized base lesion DNA N-glycosylase activity	"Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]	OMA
NV2t012062001.1	molecular_function	GO:0004844	uracil DNA N-glycosylase activity	"Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623]	OMA
NV2t012062001.1	molecular_function	GO:0017065	single-strand selective uracil DNA N-glycosylase activity	"Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623]	InterPro
NV2t012063001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t012063001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012063002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t012063002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012063002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012064001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t012064001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012064001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012066001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012066001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t012066001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t012066001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t012066001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012066001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012066001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012066001.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t012066001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012070001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012070001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012070001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t012071001.1	molecular_function	GO:0000062	fatty-acyl-CoA binding	"Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]	InterPro
NV2t012072001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	PANTHER
NV2t012072001.1	molecular_function	GO:0000062	fatty-acyl-CoA binding	"Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]	InterPro
NV2t012073001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t012073001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t012073001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t012075001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012075001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012075001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012077001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012077001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t012077001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012077002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012078001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t012078001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t012078001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012078001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t012080001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t012080001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t012081001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t012081001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t012081001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	PANTHER
NV2t012081001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t012081001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t012081001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t012081001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t012082001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012082001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t012082001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012082001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012082001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012083001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t012083001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t012083001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t012083001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t012083001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t012083001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t012083001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t012086001.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t012086001.1	biological_process	GO:0035999	tetrahydrofolate interconversion	"The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999]	PANTHER
NV2t012086001.1	biological_process	GO:0046653	tetrahydrofolate metabolic process	"The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	OMA
NV2t012086001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t012086001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t012086001.1	molecular_function	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	"Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22812]	InterPro
NV2t012086001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t012086001.1	molecular_function	GO:0019238	cyclohydrolase activity	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah]	OMA
NV2t012087001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t012087001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012087001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012087001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t012087001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t012087001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t012087001.1	molecular_function	GO:0060590	ATPase regulator activity	"Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]	OMA
NV2t012088001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012088001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	PANTHER
NV2t012088001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012089001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012089001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t012089001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012089001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012089001.1	molecular_function	GO:0015377	chloride:monoatomic cation symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [PMID:31747317]	OMA
NV2t012089001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t012090001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t012090001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t012090002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012090002.1	cellular_component	GO:0044665	MLL1/2 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t012090002.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t012090002.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t012090002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t012090002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t012090002.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t012091001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012091001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t012091002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012091002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t012092001.1	biological_process	GO:0044341	sodium-dependent phosphate transport	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]	InterPro
NV2t012092001.1	biological_process	GO:0044341	sodium-dependent phosphate transport	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]	OMA
NV2t012092001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012092001.1	molecular_function	GO:0005436	sodium:phosphate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [TC:2.A.1.14.6]	OMA
NV2t012092002.1	biological_process	GO:0044341	sodium-dependent phosphate transport	"The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]	InterPro
NV2t012093001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t012093001.1	biological_process	GO:0019725	cellular homeostasis	"Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]	OMA
NV2t012093001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t012093001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t012093001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t012093001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012093001.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t012093001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	InterPro
NV2t012093001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t012096001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012096001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012096001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t012096001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t012096001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t012096001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012096001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t012098001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012098001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012098001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012098002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012098002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012098003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012098003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012098004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012098004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012098005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012098005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012100001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012100001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012100001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012100001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t012102001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t012102001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012102001.1	cellular_component	GO:0070603	SWI/SNF superfamily-type complex	"A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938]	OMA
NV2t012104001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t012104001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t012104001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t012106001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012106001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t012106001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012106002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012106002.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t012106002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012106003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012106003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012106003.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	OMA
NV2t012106003.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t012106003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012106003.1	cellular_component	GO:0048179	activin receptor complex	"A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651]	OMA
NV2t012106003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012106003.1	molecular_function	GO:0017002	activin receptor activity	"Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta." [GOC:mah, GOC:signaling, ISBN:0198506732]	OMA
NV2t012106003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012106003.1	molecular_function	GO:0048185	activin binding	"Binding to activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah]	OMA
NV2t012107003.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t012107003.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t012107003.1	biological_process	GO:0035162	embryonic hemopoiesis	"The stages of blood cell formation that take place within the embryo." [GOC:bf]	OMA
NV2t012107003.1	biological_process	GO:0045746	negative regulation of Notch signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t012107003.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t012107003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012108001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t012108001.1	biological_process	GO:0007229	integrin-mediated signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t012108001.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	OMA
NV2t012108001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t012108001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t012108001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	InterPro
NV2t012108001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	OMA
NV2t012108001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t012108001.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t012109001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012109001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012109001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t012111001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t012111001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t012111001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012111001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012111001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t012112001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012113001.1	biological_process	GO:0071076	RNA 3' uridylation	"The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule." [GOC:vw, PMID:19430462]	OMA
NV2t012113001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t012113001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t012113001.1	molecular_function	GO:0050265	RNA uridylyltransferase activity	"Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN]	OMA
NV2t012113001.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	PANTHER
NV2t012114001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t012114001.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t012114001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t012114001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t012114001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012115001.1	biological_process	GO:0002183	cytoplasmic translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]	OMA
NV2t012115001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t012115001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012115001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012115001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t012115001.1	molecular_function	GO:0003727	single-stranded RNA binding	"Binding to single-stranded RNA." [GOC:jl]	OMA
NV2t012115001.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	OMA
NV2t012115001.1	molecular_function	GO:0140666	annealing activity	"An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule." [PMID:22888405]	OMA
NV2t012116001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t012116001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t012116001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t012116001.1	biological_process	GO:0030100	regulation of endocytosis	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]	OMA
NV2t012116001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t012116001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t012116001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012116001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t012116001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012116001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012116001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012116001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012116002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t012116002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012117001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012117001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012118002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012119001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t012119001.1	molecular_function	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	"Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators]	PANTHER
NV2t012119002.1	molecular_function	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	"Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators]	PANTHER
NV2t012119003.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t012119003.1	molecular_function	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	"Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators]	PANTHER
NV2t012119004.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t012119004.1	molecular_function	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	"Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators]	PANTHER
NV2t012120001.1	biological_process	GO:0042823	pyridoxal phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]	PANTHER
NV2t012120001.1	molecular_function	GO:0004733	pyridoxamine phosphate oxidase activity	"Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + hydrogen peroxide." [PMID:11786019]	OMA
NV2t012120001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	InterPro
NV2t012120001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t012120001.1	molecular_function	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t012120001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t012120001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t012121001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t012121001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012121002.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t012121002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012122001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t012122001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t012122001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t012122001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t012122001.1	biological_process	GO:0040008	regulation of growth	"Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]	OMA
NV2t012122001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t012122001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t012122001.1	biological_process	GO:0051248	negative regulation of protein metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t012122001.1	biological_process	GO:0070887	cellular response to chemical stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]	OMA
NV2t012122001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012122001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t012122001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012123001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t012123001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t012123001.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t012123001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t012123001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t012123001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t012123001.1	cellular_component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	"The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]	OMA
NV2t012123001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t012123001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t012123001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t012125001.1	biological_process	GO:0009132	nucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t012125001.1	biological_process	GO:1901292	nucleoside phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie]	OMA
NV2t012125001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012125001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012125001.1	molecular_function	GO:0004382	GDP phosphatase activity	"Catalysis of the reaction: GDP + H2O = GMP + phosphate." [PMID:2989286, RHEA:22156]	OMA
NV2t012125001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t012125001.1	molecular_function	GO:0045134	UDP phosphatase activity	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]	OMA
NV2t012126001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t012126001.1	molecular_function	GO:0019202	amino acid kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]	OMA
NV2t012126001.1	molecular_function	GO:0019202	amino acid kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]	PANTHER
NV2t012126002.1	molecular_function	GO:0019202	amino acid kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]	PANTHER
NV2t012127001.1	biological_process	GO:0006448	regulation of translational elongation	"Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]	OMA
NV2t012127001.1	biological_process	GO:0017183	protein histidyl modification to diphthamide	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380]	PANTHER
NV2t012127001.1	biological_process	GO:0018202	peptidyl-histidine modification	"The modification of peptidyl-histidine." [GOC:ma]	OMA
NV2t012127001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t012127001.1	molecular_function	GO:0016880	acid-ammonia (or amide) ligase activity	"Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	OMA
NV2t012128001.1	biological_process	GO:0016925	protein sumoylation	"The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]	OMA
NV2t012128001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t012128001.1	biological_process	GO:0033233	regulation of protein sumoylation	"Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]	OMA
NV2t012128001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012128001.1	biological_process	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t012128001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012128001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t012128001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t012128001.1	molecular_function	GO:0008022	obsolete protein C-terminus binding	"OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t012128001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t012128001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	OMA
NV2t012128001.1	molecular_function	GO:0043008	ATP-dependent protein binding	"Binding to a protein or protein complex using energy from ATP hydrolysis." [GOC:jl]	OMA
NV2t012128001.1	molecular_function	GO:0044388	small protein activating enzyme binding	"Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme." [GOC:jl]	OMA
NV2t012128001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t012128002.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t012128002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012128002.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t012128003.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t012128003.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012128003.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t012128004.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t012128004.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012128004.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t012128005.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t012128005.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012128005.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t012129001.1	biological_process	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	"Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]	PANTHER
NV2t012129001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t012129001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012130001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t012130001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012130001.1	cellular_component	GO:0070531	BRCA1-A complex	"A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749]	PANTHER
NV2t012130001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012130001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t012130001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012130001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012130001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012132001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	InterPro
NV2t012135001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t012135001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t012135001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012135002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t012135002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012137001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t012137001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t012137001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012138001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012138001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t012138002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012138002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t012138003.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t012138003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012138004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012138004.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t012140001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t012140001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t012140001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t012140001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t012140001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t012141001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t012141001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	OMA
NV2t012141001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	PANTHER
NV2t012141001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	InterPro
NV2t012141001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	OMA
NV2t012141001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012141001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012141001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012141001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t012141001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t012142001.1	biological_process	GO:0007409	axonogenesis	"De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]	OMA
NV2t012142001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t012142001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t012142001.1	biological_process	GO:0048588	developmental cell growth	"The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t012142001.1	biological_process	GO:0060560	developmental growth involved in morphogenesis	"The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph]	OMA
NV2t012142001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012142001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t012143001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t012144001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t012144002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t012145001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t012145001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012145001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012145001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012147001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t012147001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012147001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012147001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012148001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012148001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012148001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t012148001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012148001.1	molecular_function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	"Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]	OMA
NV2t012148001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012148001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012149001.1	biological_process	GO:0015850	organic hydroxy compound transport	"The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]	OMA
NV2t012149001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012149001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012149001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012149001.1	molecular_function	GO:0008028	monocarboxylic acid transmembrane transporter activity	"Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]	OMA
NV2t012149001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t012149001.1	molecular_function	GO:1901618	organic hydroxy compound transmembrane transporter activity	"Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t012149001.1	molecular_function	GO:1901702	salt transmembrane transporter activity	"Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t012149002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012149002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012149002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t012152001.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t012152001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t012152001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t012152001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	OMA
NV2t012152001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t012155001.1	biological_process	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	OMA
NV2t012155001.1	biological_process	GO:1900364	obsolete negative regulation of mRNA polyadenylation	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie]	InterPro
NV2t012155001.1	biological_process	GO:1900364	obsolete negative regulation of mRNA polyadenylation	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie]	OMA
NV2t012155001.1	molecular_function	GO:0008143	poly(A) binding	"Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]	OMA
NV2t012155001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012155001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t012157001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012157001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012157001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t012158001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t012158001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t012158001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t012158001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t012158001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t012158001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t012158001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t012159001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t012159001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t012159001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t012160001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t012160001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012160001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012160002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t012160002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012161001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t012161001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t012161001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t012161001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t012161001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t012164001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t012164001.1	biological_process	GO:0007229	integrin-mediated signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t012164001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t012164001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t012164001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t012164001.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	OMA
NV2t012164001.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	PANTHER
NV2t012164001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t012164001.1	biological_process	GO:0051094	positive regulation of developmental process	"Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t012164001.1	biological_process	GO:0051146	striated muscle cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai]	OMA
NV2t012164001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t012164001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t012164001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	OMA
NV2t012164001.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t012164001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t012164002.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	PANTHER
NV2t012165001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t012165001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012166001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t012166001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012169001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t012169001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012172001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t012172001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012173001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t012173001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t012173001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012181001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012181001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012183001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012184001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012184001.1	biological_process	GO:0061099	negative regulation of protein tyrosine kinase activity	"Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb]	PANTHER
NV2t012185001.1	biological_process	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	"Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]	PANTHER
NV2t012187001.1	biological_process	GO:0006479	protein methylation	"The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]	OMA
NV2t012187001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t012187001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	OMA
NV2t012187001.1	biological_process	GO:0031167	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	OMA
NV2t012187001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t012187001.1	biological_process	GO:0051171	obsolete regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t012187001.1	biological_process	GO:0070476	rRNA (guanine-N7)-methylation	"The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah]	PANTHER
NV2t012187001.1	biological_process	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	OMA
NV2t012187001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t012187001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t012187001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t012187002.1	biological_process	GO:0070476	rRNA (guanine-N7)-methylation	"The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah]	PANTHER
NV2t012189001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t012189001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012189001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012189002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t012189002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012189002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012189003.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t012189003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012189004.1	biological_process	GO:0030048	actin filament-based movement	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]	OMA
NV2t012189004.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	OMA
NV2t012189004.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	OMA
NV2t012189004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012189004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012189004.1	cellular_component	GO:0005902	microvillus	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]	OMA
NV2t012189004.1	cellular_component	GO:0005903	brush border	"The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]	OMA
NV2t012189004.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t012189004.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t012189004.1	cellular_component	GO:0030175	filopodium	"Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]	OMA
NV2t012189004.1	molecular_function	GO:0000146	microfilament motor activity	"A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]	OMA
NV2t012189004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012189004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012189004.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t012189004.1	molecular_function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	"Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t012189004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t012189004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012189005.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t012189005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012189005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012190001.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t012190001.1	biological_process	GO:0001764	neuron migration	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]	OMA
NV2t012190001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012190001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t012190001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t012190001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t012190001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012190001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t012190001.1	biological_process	GO:0007416	synapse assembly	"The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah]	OMA
NV2t012190001.1	biological_process	GO:0007422	peripheral nervous system development	"The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010]	OMA
NV2t012190001.1	biological_process	GO:0008045	motor neuron axon guidance	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]	OMA
NV2t012190001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t012190001.1	biological_process	GO:0010001	glial cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]	OMA
NV2t012190001.1	biological_process	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t012190001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t012190001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t012190001.1	biological_process	GO:0021954	central nervous system neuron development	"The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t012190001.1	biological_process	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	OMA
NV2t012190001.1	biological_process	GO:0030534	adult behavior	"Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099]	OMA
NV2t012190001.1	biological_process	GO:0032387	negative regulation of intracellular transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t012190001.1	biological_process	GO:0032388	positive regulation of intracellular transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t012190001.1	biological_process	GO:0043525	positive regulation of neuron apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t012190001.1	biological_process	GO:0045055	regulated exocytosis	"A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]	OMA
NV2t012190001.1	biological_process	GO:0045786	negative regulation of cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t012190001.1	biological_process	GO:0045861	negative regulation of proteolysis	"Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	OMA
NV2t012190001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012190001.1	biological_process	GO:0048167	regulation of synaptic plasticity	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]	OMA
NV2t012190001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t012190001.1	biological_process	GO:0048489	synaptic vesicle transport	"The directed movement of synaptic vesicles." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr]	OMA
NV2t012190001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t012190001.1	biological_process	GO:0048638	regulation of developmental growth	"Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]	OMA
NV2t012190001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t012190001.1	biological_process	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t012190001.1	biological_process	GO:0051222	positive regulation of protein transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t012190001.1	biological_process	GO:0051402	neuron apoptotic process	"Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis]	OMA
NV2t012190001.1	biological_process	GO:0051960	regulation of nervous system development	"Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	OMA
NV2t012190001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	OMA
NV2t012190001.1	biological_process	GO:0060284	regulation of cell development	"Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]	OMA
NV2t012190001.1	biological_process	GO:0099175	regulation of postsynapse organization	"Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t012190001.1	biological_process	GO:1901215	obsolete negative regulation of neuron death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t012190001.1	biological_process	GO:1901653	cellular response to peptide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t012190001.1	biological_process	GO:1903076	regulation of protein localization to plasma membrane	"Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]	OMA
NV2t012190001.1	biological_process	GO:1903828	negative regulation of protein localization	"Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t012190001.1	cellular_component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	"Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]	OMA
NV2t012190001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012190001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012190001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t012190001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t012190001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012190001.1	cellular_component	GO:0016533	protein kinase 5 complex	"A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent." [PMID:15689152]	OMA
NV2t012190001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t012190001.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t012190001.1	cellular_component	GO:0031594	neuromuscular junction	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]	OMA
NV2t012190001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t012190001.1	molecular_function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	"Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]	OMA
NV2t012190001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t012190001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012190001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012190001.1	molecular_function	GO:0030546	signaling receptor activator activity	"The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb]	OMA
NV2t012190001.1	molecular_function	GO:0035173	histone kinase activity	"Catalysis of the transfer of a phosphate group to a histone." [GOC:bf]	OMA
NV2t012190001.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	OMA
NV2t012192001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t012193001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t012193001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012193002.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t012193002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012194001.1	biological_process	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	InterPro
NV2t012195001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t012195001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012197001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012197001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t012197001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t012197001.1	biological_process	GO:0032386	regulation of intracellular transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t012197001.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	OMA
NV2t012197001.1	biological_process	GO:0060632	regulation of microtubule-based movement	"Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]	OMA
NV2t012197001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	OMA
NV2t012197001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t012197001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t012197001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012197001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012197002.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t012197002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012197003.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t012197003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012197004.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t012197004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012198001.1	cellular_component	GO:0071014	post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]	PANTHER
NV2t012198001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t012198001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t012199001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t012199001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012199001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012199001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012199001.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	InterPro
NV2t012199001.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	OMA
NV2t012200001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t012200001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t012200001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t012200001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012200001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t012200001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012200001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t012200001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012200001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012201001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t012201001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t012201001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t012201001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012201001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t012201001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t012201001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012201002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012201002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012201002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012202001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t012202001.1	biological_process	GO:2000001	regulation of DNA damage checkpoint	"Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]	OMA
NV2t012202001.1	biological_process	GO:2000001	regulation of DNA damage checkpoint	"Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]	PANTHER
NV2t012202001.1	cellular_component	GO:0000792	heterochromatin	"A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156]	OMA
NV2t012202001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012202001.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	OMA
NV2t012202001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012202001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012202001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t012203001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012203001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012203002.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012203002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012203003.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012203003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012203004.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012203004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012205001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012206001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t012206001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012207001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t012207001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012207002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t012207002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012208001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t012208001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012212001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t012213001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t012213001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t012213001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012213001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t012213001.1	molecular_function	GO:0045174	glutathione dehydrogenase (ascorbate) activity	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424]	OMA
NV2t012213001.1	molecular_function	GO:0045174	glutathione dehydrogenase (ascorbate) activity	"Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424]	PANTHER
NV2t012214001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t012214001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t012214001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t012214001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t012214001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t012214001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t012214001.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	OMA
NV2t012214001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t012214001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	OMA
NV2t012214001.1	biological_process	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t012214001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	OMA
NV2t012214001.1	biological_process	GO:2000379	positive regulation of reactive oxygen species metabolic process	"Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]	OMA
NV2t012214001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t012214001.1	cellular_component	GO:0071782	endoplasmic reticulum tubular network	"A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	OMA
NV2t012214001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012214001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t012214001.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	OMA
NV2t012214001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t012214001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t012214001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t012214001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t012215001.1	molecular_function	GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	"Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]	InterPro
NV2t012215001.1	molecular_function	GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	"Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]	OMA
NV2t012215001.1	molecular_function	GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	"Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]	PANTHER
NV2t012215001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t012215001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t012217001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012217001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t012217002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012219001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012219001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t012219001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t012219001.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t012219001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012219001.1	cellular_component	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t012219001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t012219001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t012219001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012219001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012219001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t012219001.1	molecular_function	GO:0051428	peptide hormone receptor binding	"Binding to a receptor for a peptide hormone." [GOC:ai]	OMA
NV2t012219001.1	molecular_function	GO:0140296	general transcription initiation factor binding	"Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018]	OMA
NV2t012219001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	OMA
NV2t012219002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t012219002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012221001.1	biological_process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194]	OMA
NV2t012221001.1	biological_process	GO:0043113	receptor clustering	"The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]	OMA
NV2t012221001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t012221001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012221001.1	molecular_function	GO:0043236	laminin binding	"Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd]	InterPro
NV2t012221001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	OMA
NV2t012222001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t012222001.1	biological_process	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	OMA
NV2t012222001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t012222001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t012222001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012222001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012222001.1	cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]	OMA
NV2t012222001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012222001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t012222002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t012222002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012222003.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t012222003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012223002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012223003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012224001.1	biological_process	GO:0010638	positive regulation of organelle organization	"Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	OMA
NV2t012224001.1	biological_process	GO:0034389	lipid droplet organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]	OMA
NV2t012224001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t012224001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t012224001.1	biological_process	GO:0048172	regulation of short-term neuronal synaptic plasticity	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]	OMA
NV2t012224001.1	biological_process	GO:0060079	excitatory postsynaptic potential	"A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef]	OMA
NV2t012224001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t012224001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t012224001.1	biological_process	GO:0090150	establishment of protein localization to membrane	"The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t012224001.1	biological_process	GO:1903233	regulation of calcium ion-dependent exocytosis of neurotransmitter	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]	OMA
NV2t012224001.1	biological_process	GO:1903296	positive regulation of glutamate secretion, neurotransmission	"Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817]	OMA
NV2t012224001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t012224001.1	cellular_component	GO:0071782	endoplasmic reticulum tubular network	"A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	OMA
NV2t012224001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t012224001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t012224002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t012224003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t012225001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t012225001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t012225001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t012225001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t012225001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t012227001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012227002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012228001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t012230001.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	PANTHER
NV2t012232001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t012232001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012233001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t012233001.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	OMA
NV2t012233001.1	biological_process	GO:0048562	embryonic organ morphogenesis	"Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t012233001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t012233001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t012233001.1	cellular_component	GO:0000242	pericentriolar material	"A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]	OMA
NV2t012233001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t012233001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t012233001.1	cellular_component	GO:0031021	interphase microtubule organizing center	"A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790]	OMA
NV2t012233001.1	cellular_component	GO:0097014	ciliary plasm	"All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]	OMA
NV2t012233001.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	OMA
NV2t012233001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012233001.1	molecular_function	GO:0045503	dynein light chain binding	"Binding to a light chain of the dynein complex." [GOC:bf]	OMA
NV2t012233001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	InterPro
NV2t012233001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	OMA
NV2t012234001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t012236001.1	biological_process	GO:0017190	N-terminal peptidyl-aspartic acid acetylation	"The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042]	OMA
NV2t012236001.1	biological_process	GO:0017196	N-terminal peptidyl-methionine acetylation	"The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]	OMA
NV2t012236001.1	biological_process	GO:0018002	N-terminal peptidyl-glutamic acid acetylation	"The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid." [RESID:AA0044]	OMA
NV2t012236001.1	biological_process	GO:0018199	peptidyl-glutamine modification	"The modification of peptidyl-glutamine." [GOC:go_curators]	OMA
NV2t012236001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012236001.1	cellular_component	GO:0031416	NatB complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]	OMA
NV2t012236001.1	cellular_component	GO:0031416	NatB complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]	PANTHER
NV2t012236001.1	molecular_function	GO:0004596	peptide alpha-N-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [GOC:mah, PMID:30054468]	OMA
NV2t012236001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t012237001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t012237001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012237001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t012237001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t012239001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t012239001.1	molecular_function	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN]	PANTHER
NV2t012240001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012242001.1	biological_process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]	OMA
NV2t012242001.1	biological_process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]	PANTHER
NV2t012242001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012242001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t012242001.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t012242001.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	InterPro
NV2t012242001.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	OMA
NV2t012242001.1	molecular_function	GO:0030291	protein serine/threonine kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah]	OMA
NV2t012242001.1	molecular_function	GO:0030551	cyclic nucleotide binding	"Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai]	OMA
NV2t012242001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t012242001.1	molecular_function	GO:0034236	protein kinase A catalytic subunit binding	"Binding to one or both of the catalytic subunits of protein kinase A." [GOC:mah]	OMA
NV2t012242001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t012245001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	InterPro
NV2t012245001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t012245001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t012245001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t012245001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t012245001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t012246001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t012247001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012247001.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	PANTHER
NV2t012247001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012247002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012247002.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	PANTHER
NV2t012247002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012248001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	PANTHER
NV2t012250001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012250002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012250003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012250004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012250005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012250006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012252001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	OMA
NV2t012252001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t012252001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012252001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012252001.1	molecular_function	GO:0008307	structural constituent of muscle	"The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]	OMA
NV2t012252002.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t012252002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012252003.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t012252003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012252004.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t012252004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012253001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t012253001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t012253001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t012253001.1	biological_process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]	OMA
NV2t012253001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	OMA
NV2t012253001.1	biological_process	GO:0044778	meiotic DNA integrity checkpoint signaling	"A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]	OMA
NV2t012253001.1	biological_process	GO:0044778	meiotic DNA integrity checkpoint signaling	"A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]	PANTHER
NV2t012253001.1	biological_process	GO:0071479	cellular response to ionizing radiation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]	OMA
NV2t012253001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t012253001.1	cellular_component	GO:0030896	checkpoint clamp complex	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]	InterPro
NV2t012253001.1	cellular_component	GO:0030896	checkpoint clamp complex	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]	OMA
NV2t012253001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t012253002.1	biological_process	GO:0044778	meiotic DNA integrity checkpoint signaling	"A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]	PANTHER
NV2t012253002.1	cellular_component	GO:0030896	checkpoint clamp complex	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]	InterPro
NV2t012254001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t012254001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t012254001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012256001.1	molecular_function	GO:0004090	carbonyl reductase (NADPH) activity	"Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]	OMA
NV2t012256001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012256001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t012256001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t012257001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	InterPro
NV2t012257001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	OMA
NV2t012257001.1	biological_process	GO:0044262	obsolete cellular carbohydrate metabolic process	"OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t012257001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012257001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	InterPro
NV2t012257001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	OMA
NV2t012257001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t012257001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t012257001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	PANTHER
NV2t012258001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012258001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t012258001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t012258001.1	biological_process	GO:0046330	positive regulation of JNK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	OMA
NV2t012258001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012258001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012258001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012261001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012261001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012261001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t012261001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t012261001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012261001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012264001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t012265001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012265001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t012265001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t012266001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t012268001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t012269001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t012271001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012271001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	PANTHER
NV2t012272001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t012274001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t012274001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012274001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012274002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t012274002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012274002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012279001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012279001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012279001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t012279001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012279001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012279001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012279001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012281001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012281001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012281001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012281001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012281001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012281001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012282001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012283001.1	biological_process	GO:0045055	regulated exocytosis	"A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]	PANTHER
NV2t012283001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012284001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t012284001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012287001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012287001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012287001.1	molecular_function	GO:0005215	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	PANTHER
NV2t012287001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t012288001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012288001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012288001.1	molecular_function	GO:0005215	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	PANTHER
NV2t012288001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t012289001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012289001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012289001.1	molecular_function	GO:0005215	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	PANTHER
NV2t012289001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t012290001.1	biological_process	GO:0070129	regulation of mitochondrial translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]	PANTHER
NV2t012290001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012292001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012293001.1	biological_process	GO:0046890	regulation of lipid biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	OMA
NV2t012293001.1	biological_process	GO:0046890	regulation of lipid biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	PANTHER
NV2t012293001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012295001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t012295001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t012295001.1	biological_process	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t012295001.1	biological_process	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	OMA
NV2t012295001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t012295001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t012295001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012295001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t012295001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t012295001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t012295001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012295001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012295001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t012295001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t012295001.1	molecular_function	GO:0048027	mRNA 5'-UTR binding	"Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]	OMA
NV2t012295001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	OMA
NV2t012295001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t012295001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t012295001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t012297001.1	molecular_function	GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity	"Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product." [EC:1.2.1.27, PMID:2768248]	InterPro
NV2t012297001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012297001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t012297001.1	molecular_function	GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity	"Catalysis of the reaction: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [EC:1.2.1.18]	PANTHER
NV2t012297002.1	molecular_function	GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity	"Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product." [EC:1.2.1.27, PMID:2768248]	InterPro
NV2t012297002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012297002.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t012297002.1	molecular_function	GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity	"Catalysis of the reaction: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [EC:1.2.1.18]	PANTHER
NV2t012298001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012298001.1	cellular_component	GO:0070176	DRM complex	"A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059]	InterPro
NV2t012298001.1	cellular_component	GO:0090571	RNA polymerase II transcription repressor complex	"A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter." [GOC:tb]	OMA
NV2t012300001.1	cellular_component	GO:0048500	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	InterPro
NV2t012301001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012301001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012301002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012301002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012302001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012302001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012305001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012305001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012306001.1	molecular_function	GO:0001784	phosphotyrosine residue binding	"Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584]	PANTHER
NV2t012308001.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	OMA
NV2t012308001.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t012308001.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t012308001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t012308001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012308002.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t012309001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t012309001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t012309001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	OMA
NV2t012309001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t012309001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	OMA
NV2t012309001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012309001.1	molecular_function	GO:0036310	ATP-dependent DNA/DNA annealing activity	"An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634, PMID:22888405]	OMA
NV2t012309001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t012309001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t012309002.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t012309002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t012312001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t012312001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t012312001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t012312001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t012312002.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t012312002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t012313001.1	biological_process	GO:0008218	bioluminescence	"The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]	InterPro
NV2t012315001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t012315001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012315001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012315001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t012317001.1	biological_process	GO:0006623	protein targeting to vacuole	"The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t012317001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t012317001.1	biological_process	GO:0032507	maintenance of protein location in cell	"Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]	OMA
NV2t012317001.1	biological_process	GO:0034067	protein localization to Golgi apparatus	"A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]	OMA
NV2t012317001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t012317001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t012320001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012320001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012320002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012320002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012320002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012320003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012320003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012324001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t012325001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012326001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t012326001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012326001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012327001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012327001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012327002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012327002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012327003.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012327003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012327004.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012327004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012327005.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012328001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t012328001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012329001.1	cellular_component	GO:0071008	U2-type post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]	PANTHER
NV2t012329002.1	cellular_component	GO:0071008	U2-type post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]	PANTHER
NV2t012329002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012329003.1	cellular_component	GO:0071008	U2-type post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]	PANTHER
NV2t012329003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012329004.1	cellular_component	GO:0071008	U2-type post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]	PANTHER
NV2t012329004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012331001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t012331001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t012331001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012331001.1	molecular_function	GO:0004869	cysteine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]	OMA
NV2t012331001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t012332001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t012332002.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t012332002.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t012332002.1	biological_process	GO:0046928	regulation of neurotransmitter secretion	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]	OMA
NV2t012332002.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t012332002.1	biological_process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	"The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels." [GOC:curators]	OMA
NV2t012332002.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t012332002.1	biological_process	GO:0060291	long-term synaptic potentiation	"A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph]	OMA
NV2t012332002.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t012332002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t012332002.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t012332002.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t012332002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012332002.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	OMA
NV2t012332002.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t012332002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012332002.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t012332002.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t012332002.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t012332003.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t012332004.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t012333001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333004.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333005.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333005.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333006.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333006.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333007.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333007.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333008.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333008.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333008.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333009.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333009.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333009.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333009.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333010.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333010.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333010.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333010.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012333011.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012333011.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012333011.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012333011.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012337001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012338001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012338001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012338001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t012340001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012340001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t012341001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t012341002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t012341003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t012341003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t012342001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012342001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012342001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012344001.1	molecular_function	GO:0004869	cysteine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]	InterPro
NV2t012345001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t012345001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t012345001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t012345001.1	molecular_function	GO:0003774	cytoskeletal motor activity	"Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]	OMA
NV2t012345001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012345001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012346001.1	biological_process	GO:0016539	intein-mediated protein splicing	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]	InterPro
NV2t012346001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t012347001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t012347001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t012347001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t012347001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	OMA
NV2t012347001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	PANTHER
NV2t012347001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t012347001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t012347001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012347001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012348001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t012348001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012348002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t012348002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012348003.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t012348003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012348003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012357001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	InterPro
NV2t012359001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t012359001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t012359001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	OMA
NV2t012360001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012360001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012360001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012361001.1	biological_process	GO:0030150	protein import into mitochondrial matrix	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]	InterPro
NV2t012361001.1	biological_process	GO:1903955	positive regulation of protein targeting to mitochondrion	"Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810]	PANTHER
NV2t012362001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t012362001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012362001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012362001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012362001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t012362001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t012362001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t012362002.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012362002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012362003.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012362003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012363001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t012363001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012364001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t012365001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t012367001.1	biological_process	GO:1902093	positive regulation of flagellated sperm motility	"Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657]	PANTHER
NV2t012367002.1	biological_process	GO:1902093	positive regulation of flagellated sperm motility	"Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657]	PANTHER
NV2t012367003.1	biological_process	GO:1902093	positive regulation of flagellated sperm motility	"Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657]	PANTHER
NV2t012367004.1	biological_process	GO:1902093	positive regulation of flagellated sperm motility	"Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657]	PANTHER
NV2t012368001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t012376001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t012376001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012376001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012377001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012377001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012382001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012382001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012384001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012384001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	InterPro
NV2t012384002.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	InterPro
NV2t012386001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t012386001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t012386001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t012386001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t012386001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012386001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	InterPro
NV2t012386001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t012386001.1	molecular_function	GO:0032549	ribonucleoside binding	"Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]	InterPro
NV2t012386001.1	molecular_function	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	OMA
NV2t012386001.1	molecular_function	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	OMA
NV2t012393001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t012393001.1	molecular_function	GO:0032549	ribonucleoside binding	"Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]	InterPro
NV2t012406001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t012406001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	InterPro
NV2t012406001.1	molecular_function	GO:0032549	ribonucleoside binding	"Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]	InterPro
NV2t012407001.1	biological_process	GO:0000070	mitotic sister chromatid segregation	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]	OMA
NV2t012407001.1	biological_process	GO:0000212	meiotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t012407001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t012407001.1	biological_process	GO:0007020	microtubule nucleation	"The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]	OMA
NV2t012407001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t012407001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	PANTHER
NV2t012407001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	InterPro
NV2t012407001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t012407001.1	cellular_component	GO:0000930	gamma-tubulin complex	"A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]	OMA
NV2t012407001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012407001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012407001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t012407001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t012407001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t012407001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t012407001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012407001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012408001.1	biological_process	GO:0006843	mitochondrial citrate transmembrane transport	"The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix." [GOC:ai, PMID:20371607]	OMA
NV2t012408001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012408001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t012408001.1	molecular_function	GO:0015137	citrate transmembrane transporter activity	"Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other." [GOC:ai, RHEA:33183]	OMA
NV2t012408001.1	molecular_function	GO:0015291	secondary active transmembrane transporter activity	"Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]	OMA
NV2t012408001.1	molecular_function	GO:0071913	citrate secondary active transmembrane transporter activity	"Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mah, GOC:mtg_transport, GOC:vw]	PANTHER
NV2t012408002.1	molecular_function	GO:0071913	citrate secondary active transmembrane transporter activity	"Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mah, GOC:mtg_transport, GOC:vw]	PANTHER
NV2t012410001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t012410001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	OMA
NV2t012410001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t012410001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012410001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012410001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012410001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t012412001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012412001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012416001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t012416001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t012416001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t012416001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012416001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012416001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012416002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t012416002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t012416002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012417001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	OMA
NV2t012417001.1	biological_process	GO:0006516	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t012417001.1	biological_process	GO:0006516	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t012417001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	OMA
NV2t012417001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	PANTHER
NV2t012417001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012417001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012417001.1	molecular_function	GO:0000224	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	"Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52]	OMA
NV2t012417001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t012418001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012418001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t012420001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012420002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012420003.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012420004.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012421001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t012421001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t012421001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t012421001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t012421001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t012421001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t012421001.1	cellular_component	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	OMA
NV2t012421001.1	cellular_component	GO:0030662	coated vesicle membrane	"The lipid bilayer surrounding a coated vesicle." [GOC:mah]	OMA
NV2t012421001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t012421001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t012421001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	PANTHER
NV2t012421001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t012421001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t012422001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t012423001.1	biological_process	GO:0007094	mitotic spindle assembly checkpoint signaling	"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]	OMA
NV2t012423001.1	biological_process	GO:0007094	mitotic spindle assembly checkpoint signaling	"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]	PANTHER
NV2t012423001.1	biological_process	GO:0022414	reproductive process	"A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]	OMA
NV2t012423001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t012423001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t012423001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012423001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t012423001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t012423001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012425001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t012428001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t012428001.1	biological_process	GO:0007094	mitotic spindle assembly checkpoint signaling	"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]	OMA
NV2t012428001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t012428001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012428001.1	cellular_component	GO:1990423	RZZ complex	"A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]	OMA
NV2t012428001.1	cellular_component	GO:1990423	RZZ complex	"A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]	PANTHER
NV2t012429001.1	biological_process	GO:0006526	arginine biosynthetic process	"The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ISBN:0198506732]	InterPro
NV2t012429001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	PANTHER
NV2t012430001.1	biological_process	GO:0006541	glutamine metabolic process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	InterPro
NV2t012430001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t012430001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t012431001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012431001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012431002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012431002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012431003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012431003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012431004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012431004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012431005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012431005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012431006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012431006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012434001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012434001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	PANTHER
NV2t012434001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t012434001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012434001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012435001.1	biological_process	GO:0006529	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	InterPro
NV2t012435001.1	biological_process	GO:0006529	asparagine biosynthetic process	"The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]	PANTHER
NV2t012435001.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t012435001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012435001.1	molecular_function	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532]	OMA
NV2t012436001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012438001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t012439001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012439002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012439003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012440001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t012440001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t012440001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012441001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012441001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t012441001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012442001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	OMA
NV2t012442001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012442001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t012443001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	OMA
NV2t012443001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012443001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t012444001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012444002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012444003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012446001.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012446002.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012446003.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012446004.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012446005.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012446006.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012446007.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012446008.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012446009.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t012448001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012448001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012449001.1	biological_process	GO:0032218	riboflavin transport	"The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]	InterPro
NV2t012449001.1	biological_process	GO:0032218	riboflavin transport	"The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]	PANTHER
NV2t012449001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t012449001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012449001.1	molecular_function	GO:0032217	riboflavin transmembrane transporter activity	"Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]	OMA
NV2t012450001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012451001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t012451001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012452001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t012452001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012453001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t012453001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012454001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	PANTHER
NV2t012456001.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	InterPro
NV2t012456001.1	biological_process	GO:0097198	obsolete histone H3-K36 trimethylation	"OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059]	InterPro
NV2t012456001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012456001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t012456001.1	molecular_function	GO:0046975	histone H3K36 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein." [GOC:ai]	InterPro
NV2t012456002.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	InterPro
NV2t012456002.1	biological_process	GO:0097198	obsolete histone H3-K36 trimethylation	"OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059]	InterPro
NV2t012456002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012456002.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t012456002.1	molecular_function	GO:0046975	histone H3K36 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein." [GOC:ai]	InterPro
NV2t012456003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012456003.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	InterPro
NV2t012456003.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	OMA
NV2t012456003.1	biological_process	GO:0097198	obsolete histone H3-K36 trimethylation	"OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059]	InterPro
NV2t012456003.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t012456003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012456003.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t012456003.1	molecular_function	GO:0046975	histone H3K36 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein." [GOC:ai]	InterPro
NV2t012456003.1	molecular_function	GO:0046975	histone H3K36 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein." [GOC:ai]	OMA
NV2t012456004.1	biological_process	GO:0097198	obsolete histone H3-K36 trimethylation	"OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059]	InterPro
NV2t012456004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012456004.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t012456004.1	molecular_function	GO:0046975	histone H3K36 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein." [GOC:ai]	InterPro
NV2t012456005.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	InterPro
NV2t012456005.1	biological_process	GO:0097198	obsolete histone H3-K36 trimethylation	"OBSOLETE. The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059]	InterPro
NV2t012456005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012456005.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t012456005.1	molecular_function	GO:0046975	histone H3K36 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein." [GOC:ai]	InterPro
NV2t012457001.1	biological_process	GO:0048311	mitochondrion distribution	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]	PANTHER
NV2t012457002.1	biological_process	GO:0048311	mitochondrion distribution	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]	PANTHER
NV2t012457003.1	biological_process	GO:0048311	mitochondrion distribution	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]	PANTHER
NV2t012457004.1	biological_process	GO:0048311	mitochondrion distribution	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]	PANTHER
NV2t012457005.1	biological_process	GO:0048311	mitochondrion distribution	"Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid]	PANTHER
NV2t012458001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012458001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012458001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012458002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012458002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012458003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012458003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012459001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012459001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012459001.1	molecular_function	GO:0016907	G protein-coupled acetylcholine receptor activity	"Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]	OMA
NV2t012463001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t012463001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t012463001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t012463001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t012463001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t012465001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	PANTHER
NV2t012466001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012467001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012467001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012468001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012468001.1	cellular_component	GO:0090571	RNA polymerase II transcription repressor complex	"A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter." [GOC:tb]	OMA
NV2t012468001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t012468001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t012468001.1	molecular_function	GO:0140223	general transcription initiation factor activity	"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]	InterPro
NV2t012468001.1	molecular_function	GO:0140223	general transcription initiation factor activity	"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]	OMA
NV2t012471001.1	biological_process	GO:0032101	regulation of response to external stimulus	"Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t012471001.1	biological_process	GO:0050878	regulation of body fluid levels	"Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t012471001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t012471001.1	biological_process	GO:0090303	positive regulation of wound healing	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]	OMA
NV2t012471001.1	molecular_function	GO:0047710	bis(5'-adenosyl)-triphosphatase activity	"Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+." [EC:3.6.1.29, RHEA:13893]	OMA
NV2t012472001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t012472001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t012472001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t012472001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t012472001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t012472001.1	cellular_component	GO:0045111	intermediate filament cytoskeleton	"Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363]	OMA
NV2t012473001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012473001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t012473001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t012475001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012475001.1	cellular_component	GO:0140672	ATAC complex	"A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation." [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424]	PANTHER
NV2t012475001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t012476001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t012476001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t012476001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012476001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t012476001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t012476001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	PANTHER
NV2t012476001.1	molecular_function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	"Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t012476001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012477001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t012477001.1	molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	"Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]	OMA
NV2t012477001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t012477001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t012478001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012481001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012481001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012481001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t012481002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012481002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012481002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t012482001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t012482001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	InterPro
NV2t012482001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	OMA
NV2t012482001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t012482001.1	cellular_component	GO:1990351	transporter complex	"A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]	OMA
NV2t012482001.1	cellular_component	GO:1990429	peroxisomal importomer complex	"A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:12667447, PMID:20154681, PMID:22375831]	PANTHER
NV2t012482001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t012482001.1	molecular_function	GO:0008022	obsolete protein C-terminus binding	"OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t012482001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012483001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012483001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012484002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t012484002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012485001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t012488001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t012488001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t012488001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t012489001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012489001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012489002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012489002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012489003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012489003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012489003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t012489003.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t012489004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012489004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012489004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012491001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t012491001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t012491001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t012491001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t012491001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t012491001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t012493001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012493001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012493001.1	molecular_function	GO:0005215	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	PANTHER
NV2t012493001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t012495001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t012495002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t012495003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t012495003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t012497001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012497001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012497001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012498001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t012498001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t012498001.1	biological_process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	"Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]	PANTHER
NV2t012498001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012498002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012500001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t012500001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012501001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t012501001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012501001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t012502001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t012502001.1	biological_process	GO:0010941	obsolete regulation of cell death	"OBSOLETE. Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]	OMA
NV2t012502001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012502001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012502001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012502001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t012503001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012503001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t012503001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t012505001.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	InterPro
NV2t012505001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	PANTHER
NV2t012507001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	PANTHER
NV2t012507001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012508001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012508001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012508001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012508001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	PANTHER
NV2t012509001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012509001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012511001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t012514001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012514001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t012514001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t012514001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t012514001.1	biological_process	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	PANTHER
NV2t012514001.1	biological_process	GO:0071900	regulation of protein serine/threonine kinase activity	"Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t012514001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012514001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012514001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t012514001.1	cellular_component	GO:1902911	protein kinase complex	"A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]	OMA
NV2t012514001.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t012514001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t012514001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t012514001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t012514001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t012516001.1	molecular_function	GO:1902444	riboflavin binding	"Binding to riboflavin." [GOC:TermGenie, PMID:12083520]	PANTHER
NV2t012518001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t012518001.1	cellular_component	GO:0097550	transcription preinitiation complex	"A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016]	PANTHER
NV2t012518001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t012519001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012520001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t012520001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	InterPro
NV2t012520001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t012520001.1	biological_process	GO:0030048	actin filament-based movement	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]	OMA
NV2t012520001.1	biological_process	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t012520001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t012520001.1	biological_process	GO:0048667	cell morphogenesis involved in neuron differentiation	"The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]	OMA
NV2t012520001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t012520001.1	biological_process	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t012520001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t012520001.1	biological_process	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	"Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476]	OMA
NV2t012520001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012520001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012520001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t012520001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t012520001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t012521001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012521001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012521001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t012521001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t012521001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t012521001.1	biological_process	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	OMA
NV2t012521001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t012521001.1	biological_process	GO:0051093	negative regulation of developmental process	"Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t012521001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t012521001.1	biological_process	GO:0060541	respiratory system development	"The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]	OMA
NV2t012521001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012521001.1	cellular_component	GO:0070776	MOZ/MORF histone acetyltransferase complex	"A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]	OMA
NV2t012521001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012521001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t012521001.1	molecular_function	GO:0140566	histone reader activity	"A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery." [PMID:11498575, PMID:25688442, PMID:31082667, PMID:32260176, PMID:34726351]	OMA
NV2t012521002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012524001.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	InterPro
NV2t012524001.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	PANTHER
NV2t012524002.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t012524002.1	biological_process	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	OMA
NV2t012524002.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	InterPro
NV2t012524002.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	OMA
NV2t012524002.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	PANTHER
NV2t012525001.1	biological_process	GO:0010230	alternative respiration	"Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399]	PANTHER
NV2t012525001.1	molecular_function	GO:0009916	alternative oxidase activity	"Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399]	InterPro
NV2t012525002.1	biological_process	GO:0010230	alternative respiration	"Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399]	PANTHER
NV2t012525002.1	molecular_function	GO:0009916	alternative oxidase activity	"Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399]	InterPro
NV2t012525002.1	molecular_function	GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]	OMA
NV2t012526001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012526001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012527001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012527002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012527003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012543001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012544001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t012544001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t012544001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t012544001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t012544001.1	cellular_component	GO:0061700	GATOR2 complex	"A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins." [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700]	OMA
NV2t012544001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012545001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t012545001.1	biological_process	GO:0008608	attachment of spindle microtubules to kinetochore	"The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137]	OMA
NV2t012545001.1	cellular_component	GO:0031262	Ndc80 complex	"An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis." [GOC:vw, PMID:28502666, PMID:34810257]	InterPro
NV2t012545001.1	cellular_component	GO:0031262	Ndc80 complex	"An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis." [GOC:vw, PMID:28502666, PMID:34810257]	OMA
NV2t012545001.1	cellular_component	GO:0031262	Ndc80 complex	"An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis." [GOC:vw, PMID:28502666, PMID:34810257]	PANTHER
NV2t012546001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t012546001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t012546001.1	biological_process	GO:0051261	protein depolymerization	"The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]	OMA
NV2t012546001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012546001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012546001.1	cellular_component	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	OMA
NV2t012546001.1	cellular_component	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	OMA
NV2t012546001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012547001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t012549001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t012549001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t012549001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012549001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012549001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012549001.1	molecular_function	GO:0050291	sphingosine N-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]	InterPro
NV2t012549001.1	molecular_function	GO:0050291	sphingosine N-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]	OMA
NV2t012555001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012557001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012557001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t012559001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012559001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012560001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t012561001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t012561001.1	biological_process	GO:0050727	regulation of inflammatory response	"Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]	OMA
NV2t012561001.1	biological_process	GO:0050764	regulation of phagocytosis	"Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai]	OMA
NV2t012561001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t012561001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t012561001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	InterPro
NV2t012561001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t012562001.1	biological_process	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	InterPro
NV2t012562001.1	biological_process	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	OMA
NV2t012562001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t012563001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012563001.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012563001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012563001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012563002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012563002.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012563002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012563002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012563004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012563004.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012563004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012563004.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012563005.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t012563005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012563005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t012563005.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t012563005.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t012563005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012563005.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012565001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012565001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012566001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t012566001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012566001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012567001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t012567001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012567001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012569001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t012569001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t012569001.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t012569001.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	PANTHER
NV2t012569001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t012569001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t012569001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t012569001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t012569001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t012569002.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	PANTHER
NV2t012570001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012570001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012570001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t012570001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012570001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012570001.1	molecular_function	GO:0030332	cyclin binding	"Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]	PANTHER
NV2t012572001.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t012572001.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	OMA
NV2t012572001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t012572001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t012572001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t012572001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t012572001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t012572001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t012572001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012572001.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	OMA
NV2t012572001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t012572001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012572001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t012572001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t012572001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t012572002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t012574001.1	biological_process	GO:0006307	DNA alkylation repair	"The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases." [PMID:10946226, PMID:35543797]	OMA
NV2t012574001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t012574001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t012574001.1	biological_process	GO:0006448	regulation of translational elongation	"Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]	OMA
NV2t012574001.1	biological_process	GO:0035552	obsolete oxidative single-stranded DNA demethylation	"OBSOLETE. Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698]	PANTHER
NV2t012574001.1	biological_process	GO:0070129	regulation of mitochondrial translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]	OMA
NV2t012574001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012574001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t012574001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t012574001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t012574001.1	molecular_function	GO:0035516	broad specificity oxidative DNA demethylase activity	"Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA." [PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499, RHEA:30299]	OMA
NV2t012574001.1	molecular_function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate." [PMID:1698278, RHEA:66592]	OMA
NV2t012574001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t012575001.1	biological_process	GO:0030322	stabilization of membrane potential	"The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t012575001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t012575001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012575001.1	molecular_function	GO:0015271	outward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]	OMA
NV2t012575001.1	molecular_function	GO:0022841	potassium ion leak channel activity	"Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t012577001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012577001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012577001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	OMA
NV2t012577001.1	biological_process	GO:0032147	activation of protein kinase activity	"Any process that initiates the activity of an inactive protein kinase." [GOC:mah]	OMA
NV2t012577001.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t012577001.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	PANTHER
NV2t012577001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t012577001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012577001.1	molecular_function	GO:0043539	protein serine/threonine kinase activator activity	"Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]	OMA
NV2t012578001.1	molecular_function	GO:0010349	L-galactose dehydrogenase activity	"Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629, RHEA:31559]	InterPro
NV2t012578001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012578001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t012578001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t012579001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012582001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012582002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012582003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t012582003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012582004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012583001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t012583001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012584001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012584001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t012584001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012585001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	OMA
NV2t012585001.1	biological_process	GO:0071569	protein ufmylation	"Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]	PANTHER
NV2t012585001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012585001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t012585001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	OMA
NV2t012585002.1	biological_process	GO:0071569	protein ufmylation	"Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]	PANTHER
NV2t012585002.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t012585003.1	biological_process	GO:0071569	protein ufmylation	"Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]	PANTHER
NV2t012585003.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t012588001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012588001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012588001.1	molecular_function	GO:0048101	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	"Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin." [GOC:jid]	PANTHER
NV2t012588002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012588002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t012588002.1	molecular_function	GO:0048101	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	"Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin." [GOC:jid]	PANTHER
NV2t012590001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t012590001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	InterPro
NV2t012590001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t012590001.1	biological_process	GO:0042744	hydrogen peroxide catabolic process	"The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]	OMA
NV2t012590001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t012590001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t012590001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t012590001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012590001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t012590001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t012590001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012590001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012590001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012590001.1	molecular_function	GO:0140824	thioredoxin-dependent peroxiredoxin activity	"Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O." [PMID:12707274, PMID:19820102, RHEA:62620]	OMA
NV2t012590002.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	InterPro
NV2t012590002.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t012590002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012591001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t012591001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t012591001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012591001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012592001.1	biological_process	GO:0000338	protein deneddylation	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]	OMA
NV2t012592001.1	biological_process	GO:0010387	COP9 signalosome assembly	"The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927]	InterPro
NV2t012592001.1	biological_process	GO:0010387	COP9 signalosome assembly	"The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927]	OMA
NV2t012592001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	OMA
NV2t012595001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012596001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t012596001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012596001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t012598001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t012598001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t012599001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t012599001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012599003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t012599003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012600001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t012600001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012600001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012600001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012600001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012600001.1	molecular_function	GO:0005518	collagen binding	"Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732]	OMA
NV2t012600001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	OMA
NV2t012600001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t012602001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012602001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012604002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012604003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012608001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t012608001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t012608001.1	biological_process	GO:1903292	protein localization to Golgi membrane	"A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902]	OMA
NV2t012608001.1	biological_process	GO:1903292	protein localization to Golgi membrane	"A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902]	PANTHER
NV2t012608001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t012608001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012608001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012608001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012608002.1	biological_process	GO:1903292	protein localization to Golgi membrane	"A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902]	PANTHER
NV2t012608002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012608003.1	biological_process	GO:1903292	protein localization to Golgi membrane	"A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902]	PANTHER
NV2t012608003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012608004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012608004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012609001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t012609001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t012609001.1	biological_process	GO:0006986	response to unfolded protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]	OMA
NV2t012609001.1	biological_process	GO:0009100	glycoprotein metabolic process	"The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t012609001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t012609001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t012609001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t012609001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t012609001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t012609001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t012609001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t012610001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012612001.1	molecular_function	GO:0120013	lipid transfer activity	"Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	InterPro
NV2t012612002.1	molecular_function	GO:0120013	lipid transfer activity	"Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	InterPro
NV2t012615001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t012615001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012615001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t012616001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t012616001.1	molecular_function	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]	OMA
NV2t012617001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012617001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t012618001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	InterPro
NV2t012618001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t012618001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t012618001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012618001.1	molecular_function	GO:0004312	fatty acid synthase activity	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]	OMA
NV2t012618001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t012620001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012626001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t012626001.1	biological_process	GO:0009435	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	InterPro
NV2t012626001.1	biological_process	GO:0019359	nicotinamide nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]	OMA
NV2t012626001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t012626001.1	biological_process	GO:0034213	quinolinate catabolic process	"The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:mah]	PANTHER
NV2t012626001.1	biological_process	GO:0043649	dicarboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t012626001.1	biological_process	GO:0072526	pyridine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	OMA
NV2t012626001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012626001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t012626001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t012627001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t012627001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t012627001.1	biological_process	GO:0030970	retrograde protein transport, ER to cytosol	"The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744]	PANTHER
NV2t012627001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t012628001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012629001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t012629001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t012629001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t012629001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t012629001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t012629001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t012629001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t012629001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t012629001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012629001.1	molecular_function	GO:0005104	fibroblast growth factor receptor binding	"Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb]	OMA
NV2t012629001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t012629001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t012629002.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t012633001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012633001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t012633001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012635001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012635001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t012635001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012635001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012636001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012637001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t012637001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t012637001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t012637001.1	biological_process	GO:0071985	multivesicular body sorting pathway	"A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]	InterPro
NV2t012637001.1	biological_process	GO:0071985	multivesicular body sorting pathway	"A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]	OMA
NV2t012637001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t012637001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012638001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t012638001.1	biological_process	GO:0018126	protein hydroxylation	"The addition of a hydroxy group to a protein amino acid." [GOC:ai]	OMA
NV2t012638001.1	biological_process	GO:0043243	positive regulation of protein-containing complex disassembly	"Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]	OMA
NV2t012638001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t012638001.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	PANTHER
NV2t012638001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012638001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012638001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t012638001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t012640001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t012640001.1	biological_process	GO:0006622	protein targeting to lysosome	"The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators]	OMA
NV2t012640001.1	biological_process	GO:0008088	axo-dendritic transport	"The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194]	OMA
NV2t012640001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t012640001.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	OMA
NV2t012640001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t012640001.1	biological_process	GO:0034620	cellular response to unfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]	OMA
NV2t012640001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t012640001.1	biological_process	GO:0051261	protein depolymerization	"The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]	OMA
NV2t012640001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t012640001.1	biological_process	GO:0061738	late endosomal microautophagy	"The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:21238931]	OMA
NV2t012640001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012640001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t012640001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t012640001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012640001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t012640001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t012640001.1	cellular_component	GO:0043195	terminal bouton	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]	OMA
NV2t012640001.1	cellular_component	GO:0099523	presynaptic cytosol	"The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos]	OMA
NV2t012640001.1	cellular_component	GO:0099524	postsynaptic cytosol	"The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos]	OMA
NV2t012640001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012640001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t012640001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	OMA
NV2t012640001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t012640001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t012640001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t012641001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t012641001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012641002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t012641002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t012641002.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t012641002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012641002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012641003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t012641003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012643001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t012643001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t012644001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t012644001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012645001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t012647001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t012648001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t012648001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t012648001.1	biological_process	GO:0009069	serine family amino acid metabolic process	"The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t012648001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t012648001.1	biological_process	GO:0046360	2-oxobutyrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732]	PANTHER
NV2t012648001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t012648001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t012650001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012650001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012650001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t012650001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012650002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012650002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012650002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t012650002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012651001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	PANTHER
NV2t012652001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	PANTHER
NV2t012652001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012653001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t012653001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012656001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012658001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t012658001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t012659001.1	biological_process	GO:0032204	regulation of telomere maintenance	"Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]	PANTHER
NV2t012659001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	OMA
NV2t012659001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012660001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	PANTHER
NV2t012660001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012662001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	InterPro
NV2t012662001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t012662001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	PANTHER
NV2t012662001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012662001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t012663001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012663001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012663001.1	molecular_function	GO:0030332	cyclin binding	"Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]	PANTHER
NV2t012664001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012664001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t012664002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012664003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012664004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012666001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t012666001.1	biological_process	GO:0019395	fatty acid oxidation	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t012666001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t012666001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t012666001.1	molecular_function	GO:0016832	aldehyde-lyase activity	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators]	OMA
NV2t012666001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t012666001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t012666001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	PANTHER
NV2t012666001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t012666001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t012666001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t012666001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t012666001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t012668001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t012668001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t012669001.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012669001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012669001.1	molecular_function	GO:0005337	nucleoside transmembrane transporter activity	"Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]	OMA
NV2t012669002.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012669003.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012669004.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012669005.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012669006.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012669007.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012669008.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012669009.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t012670001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t012670001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	InterPro
NV2t012670001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t012670002.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	InterPro
NV2t012672001.1	biological_process	GO:0097105	presynaptic membrane assembly	"The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:15797875, PMID:18550748]	PANTHER
NV2t012676001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012676001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t012676001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012676001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012676002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t012676002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t012678001.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t012678001.1	biological_process	GO:0030514	negative regulation of BMP signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]	OMA
NV2t012678001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	InterPro
NV2t012678001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012678001.1	molecular_function	GO:0036122	BMP binding	"Binding to a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951]	OMA
NV2t012678001.1	molecular_function	GO:0036122	BMP binding	"Binding to a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951]	PANTHER
NV2t012679001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t012679001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t012679002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t012679002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t012679003.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t012679003.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t012679003.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t012679003.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t012679003.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t012679003.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t012679003.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t012679003.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t012679003.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t012679004.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t012679004.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t012681001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012681001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012681001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t012681001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t012681001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012681002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012681002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t012681002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012682001.1	biological_process	GO:0000725	recombinational repair	"A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh]	InterPro
NV2t012682001.1	biological_process	GO:0000725	recombinational repair	"A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh]	OMA
NV2t012686001.1	biological_process	GO:0006382	adenosine to inosine editing	"The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837]	OMA
NV2t012686001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t012686001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t012686001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t012686001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012686001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t012686001.1	molecular_function	GO:0003726	double-stranded RNA adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah, RHEA:10120]	OMA
NV2t012686001.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	OMA
NV2t012686001.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t012688001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012692001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012693001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t012693001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t012693001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012693001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012693001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t012693001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t012693001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t012693001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t012693001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t012693001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t012693002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t012693002.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t012693002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012693003.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t012693003.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t012693003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012694001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t012694001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012695001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012695001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t012695001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	InterPro
NV2t012695002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012695002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t012695003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012695003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t012695003.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	InterPro
NV2t012697001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012697001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012697002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012698001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012698001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t012698001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	PANTHER
NV2t012698001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t012698001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t012699001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012699001.1	biological_process	GO:0048525	negative regulation of viral process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]	OMA
NV2t012699001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012699001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012699001.1	molecular_function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	OMA
NV2t012700001.1	biological_process	GO:0090071	negative regulation of ribosome biogenesis	"Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]	PANTHER
NV2t012701001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t012701001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012703001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t012703001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t012703001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t012703001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t012703001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t012703001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t012703001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t012704001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t012704001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t012704001.1	molecular_function	GO:0005104	fibroblast growth factor receptor binding	"Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb]	OMA
NV2t012704001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t012704001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t012709001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012709001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012709001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012709001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t012709001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t012710001.1	biological_process	GO:0006605	protein targeting	"The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	OMA
NV2t012710001.1	biological_process	GO:0090160	Golgi to lysosome transport	"The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t012710001.1	biological_process	GO:0090160	Golgi to lysosome transport	"The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t012710001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t012710001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t012710001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	OMA
NV2t012710001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t012711001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012712001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012714001.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012714002.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t012714002.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t012714002.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012714002.1	cellular_component	GO:0042641	actomyosin	"Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]	OMA
NV2t012714002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t012714002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012714002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012714003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012714003.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012714004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012714004.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012714005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012714005.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012714006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012714006.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012714007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012714007.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012714008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012714008.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714009.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012714009.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t012714009.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012716001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t012716001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012716001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012716001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t012719001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t012719001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012721001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t012721001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t012721001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t012721001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t012721001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012721001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012721001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012722001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012722001.1	biological_process	GO:0031126	sno(s)RNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea." [GOC:krc, GOC:mah, PMID:17284456]	OMA
NV2t012722001.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t012722001.1	cellular_component	GO:0120259	7SK snRNP	"A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb." [PMID:18249148, PMID:28431135]	OMA
NV2t012722001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t012722001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012722001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t012722001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	PANTHER
NV2t012722001.1	molecular_function	GO:0017070	U6 snRNA binding	"Binding to a U6 small nuclear RNA (U6 snRNA)." [GOC:mah]	OMA
NV2t012722001.1	molecular_function	GO:0097322	7SK snRNA binding	"Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533]	OMA
NV2t012723001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t012726001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012726001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012727001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012727001.1	biological_process	GO:0140206	dipeptide import across plasma membrane	"The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]	PANTHER
NV2t012727001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t012727002.1	biological_process	GO:0035442	dipeptide transmembrane transport	"The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:vw]	OMA
NV2t012727002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012727002.1	biological_process	GO:0140206	dipeptide import across plasma membrane	"The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]	PANTHER
NV2t012727002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012727002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t012727002.1	molecular_function	GO:0035673	oligopeptide transmembrane transporter activity	"Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732]	OMA
NV2t012728002.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t012728002.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t012728002.1	cellular_component	GO:0070461	SAGA-type complex	"A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]	OMA
NV2t012728002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012728002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012728002.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t012728002.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	PANTHER
NV2t012730001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t012730001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012731001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t012731001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t012731001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t012731001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t012731001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012731001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t012731002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t012732001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t012732001.1	biological_process	GO:0006403	RNA localization	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t012732001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t012732001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t012732001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012732001.1	cellular_component	GO:0070761	pre-snoRNP complex	"A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390]	PANTHER
NV2t012732001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t012732001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012733001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t012733001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t012733001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t012733001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t012733001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012733001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012733001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t012733001.1	cellular_component	GO:0072380	TRC complex	"A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane." [GOC:mah, PMID:20850366, PMID:23142665]	PANTHER
NV2t012733001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012733001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012733001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t012734001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t012734001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t012734001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012734001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t012734001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012734001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012734001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012734001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012734001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012734001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012735001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t012735001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012736001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012736001.1	molecular_function	GO:0016842	amidine-lyase activity	"Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]	OMA
NV2t012736001.1	molecular_function	GO:0061929	gamma-glutamylaminecyclotransferase activity	"Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline." [PMID:20110353, PMID:6107907]	InterPro
NV2t012738001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t012740001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	PANTHER
NV2t012741001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012741001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012743001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t012743001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012743001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012743001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012744001.1	biological_process	GO:0001659	temperature homeostasis	"A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl]	OMA
NV2t012744001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t012744001.1	biological_process	GO:0009266	response to temperature stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb]	OMA
NV2t012744001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t012744001.1	biological_process	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	OMA
NV2t012744001.1	biological_process	GO:0042542	response to hydrogen peroxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]	OMA
NV2t012744001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t012744001.1	biological_process	GO:0051489	regulation of filopodium assembly	"Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t012744001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t012744001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012744001.1	biological_process	GO:0060326	cell chemotaxis	"The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]	OMA
NV2t012744001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t012744001.1	biological_process	GO:0071415	cellular response to purine-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:mah]	OMA
NV2t012744001.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	OMA
NV2t012744001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t012744001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t012744001.1	biological_process	GO:2000249	obsolete regulation of actin cytoskeleton reorganization	"OBSOLETE. Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]	OMA
NV2t012744001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t012744001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012744001.1	cellular_component	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	OMA
NV2t012744001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012744001.1	molecular_function	GO:0015278	intracellularly gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t012744001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t012744001.1	molecular_function	GO:0047631	ADP-ribose diphosphatase activity	"Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]	OMA
NV2t012744001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t012744001.1	molecular_function	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	OMA
NV2t012744001.1	molecular_function	GO:0099604	ligand-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:dos]	PANTHER
NV2t012744001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t012744002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012744002.1	molecular_function	GO:0099604	ligand-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:dos]	PANTHER
NV2t012745001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012745001.1	biological_process	GO:0086011	membrane repolarization during action potential	"The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t012745001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012745001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012745001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t012747001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012747001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012747001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t012749001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012749001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012749001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t012749001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012751001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012751001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012751001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t012752001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012753001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t012753001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012753002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012755001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t012755001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012756001.1	biological_process	GO:0016482	cytosolic transport	"The directed movement of substances or organelles within the cytosol." [GOC:ai]	OMA
NV2t012756001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t012756001.1	biological_process	GO:0046627	negative regulation of insulin receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]	OMA
NV2t012756001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	PANTHER
NV2t012756001.1	biological_process	GO:0061909	autophagosome-lysosome fusion	"The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [PMID:28077293]	OMA
NV2t012756001.1	biological_process	GO:0090219	negative regulation of lipid kinase activity	"Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb]	OMA
NV2t012756001.1	biological_process	GO:2000786	positive regulation of autophagosome assembly	"Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t012756001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t012756001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t012756001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012756001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012756001.1	molecular_function	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+." [EC:2.7.1.68, RHEA:14425]	OMA
NV2t012756001.1	molecular_function	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity	"Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149]	OMA
NV2t012756001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t012756001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	InterPro
NV2t012756002.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	PANTHER
NV2t012756002.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	InterPro
NV2t012758001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t012758001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t012758001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t012759001.1	biological_process	GO:0018095	protein polyglutamylation	"The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202]	InterPro
NV2t012759001.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t012759001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t012759001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t012760001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t012760001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012760001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t012760001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t012760001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012760001.1	molecular_function	GO:0008201	heparin binding	"Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t012766001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t012766001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t012769001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t012769001.1	molecular_function	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	"Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai]	PANTHER
NV2t012770001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012775001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t012775001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	PANTHER
NV2t012776001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t012778001.1	biological_process	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t012778001.1	biological_process	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t012778001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	InterPro
NV2t012778001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t012778001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012778001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012778001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t012778001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t012778001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t012780001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t012785001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012785001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012785001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012785001.1	molecular_function	GO:0015267	channel activity	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t012785001.1	molecular_function	GO:0015267	channel activity	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t012786001.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	PANTHER
NV2t012786001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t012786002.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	PANTHER
NV2t012786002.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t012789001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012789001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012789001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t012789001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t012789001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012792001.1	cellular_component	GO:0071564	npBAF complex	"A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells." [GOC:mah, GOC:ss, PMID:17640523]	InterPro
NV2t012792002.1	cellular_component	GO:0071564	npBAF complex	"A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells." [GOC:mah, GOC:ss, PMID:17640523]	InterPro
NV2t012793001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012793001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012793001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012793001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012793001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012793001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012795001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012795001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012795001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012799001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012799001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012799001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012802002.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t012802002.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t012802002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t012802002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012802002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t012802002.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t012802002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t012803001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t012803001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012803001.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	OMA
NV2t012803001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	PANTHER
NV2t012806001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t012806001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012806001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012808001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	InterPro
NV2t012808001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t012808001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t012808001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t012808001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t012808001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t012808001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t012809001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t012809001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t012809001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t012809001.1	biological_process	GO:0051103	DNA ligation involved in DNA repair	"The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai]	InterPro
NV2t012809001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012809001.1	molecular_function	GO:0003910	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	InterPro
NV2t012809001.1	molecular_function	GO:0003910	DNA ligase (ATP) activity	"Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]	OMA
NV2t012809001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012810001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t012810001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t012810001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t012810001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t012810001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t012811001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t012811001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t012812001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t012812001.1	molecular_function	GO:0070888	E-box binding	"Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799]	PANTHER
NV2t012812002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t012812002.1	molecular_function	GO:0070888	E-box binding	"Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799]	PANTHER
NV2t012814001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012814001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t012814001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012814001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012814001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t012814001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t012814002.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t012814002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012814002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t012814003.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t012814003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012814003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t012815001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012815001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012815001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012815001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t012815001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012815001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012816001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012821001.1	cellular_component	GO:0071339	MLL1 complex	"A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975]	PANTHER
NV2t012822001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012822001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t012822002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012822002.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t012822003.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t012822003.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012822003.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t012822004.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012822004.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t012825003.1	biological_process	GO:0032526	response to retinoic acid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl]	PANTHER
NV2t012825003.1	biological_process	GO:0033993	response to lipid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]	OMA
NV2t012825003.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t012825003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012825003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012825003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t012826001.1	biological_process	GO:0008154	actin polymerization or depolymerization	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t012826001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t012826001.1	cellular_component	GO:0098858	actin-based cell projection	"A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]	PANTHER
NV2t012826001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012826001.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	OMA
NV2t012826001.1	molecular_function	GO:0030296	protein tyrosine kinase activator activity	"Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732]	OMA
NV2t012826002.1	cellular_component	GO:0098858	actin-based cell projection	"A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]	PANTHER
NV2t012826002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012828001.1	cellular_component	GO:0098858	actin-based cell projection	"A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]	PANTHER
NV2t012828002.1	cellular_component	GO:0098858	actin-based cell projection	"A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]	PANTHER
NV2t012828003.1	cellular_component	GO:0098858	actin-based cell projection	"A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]	PANTHER
NV2t012828004.1	cellular_component	GO:0098858	actin-based cell projection	"A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519]	PANTHER
NV2t012829002.1	biological_process	GO:0007129	homologous chromosome pairing at meiosis	"The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]	OMA
NV2t012829002.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t012829002.1	biological_process	GO:0033233	regulation of protein sumoylation	"Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]	OMA
NV2t012829002.1	biological_process	GO:0034502	protein localization to chromosome	"Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah]	OMA
NV2t012829002.1	biological_process	GO:0045835	negative regulation of meiotic nuclear division	"Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]	OMA
NV2t012829002.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	OMA
NV2t012829002.1	biological_process	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t012829002.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	OMA
NV2t012829002.1	cellular_component	GO:0000795	synaptonemal complex	"A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh]	OMA
NV2t012829002.1	molecular_function	GO:0032183	SUMO binding	"Binding to the small ubiquitin-like protein SUMO." [GOC:mah]	OMA
NV2t012831001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012831001.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	PANTHER
NV2t012831001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012831002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012831002.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	PANTHER
NV2t012831002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012831003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012831003.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	PANTHER
NV2t012831003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012831004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012831004.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	PANTHER
NV2t012831004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012838001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t012838001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t012838001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012838001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t012841001.1	biological_process	GO:0080163	regulation of protein serine/threonine phosphatase activity	"Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]	PANTHER
NV2t012841002.1	biological_process	GO:0080163	regulation of protein serine/threonine phosphatase activity	"Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]	PANTHER
NV2t012841003.1	biological_process	GO:0080163	regulation of protein serine/threonine phosphatase activity	"Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]	PANTHER
NV2t012841004.1	biological_process	GO:0080163	regulation of protein serine/threonine phosphatase activity	"Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]	PANTHER
NV2t012841005.1	biological_process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	"Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah]	OMA
NV2t012841005.1	biological_process	GO:0080163	regulation of protein serine/threonine phosphatase activity	"Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]	OMA
NV2t012841005.1	biological_process	GO:0080163	regulation of protein serine/threonine phosphatase activity	"Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]	PANTHER
NV2t012841005.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012841005.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t012841005.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t012841006.1	biological_process	GO:0080163	regulation of protein serine/threonine phosphatase activity	"Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142]	PANTHER
NV2t012843001.1	biological_process	GO:0006535	cysteine biosynthetic process from serine	"The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]	InterPro
NV2t012843001.1	biological_process	GO:0019344	cysteine biosynthetic process	"The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]	PANTHER
NV2t012843002.1	biological_process	GO:0006535	cysteine biosynthetic process from serine	"The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]	InterPro
NV2t012843002.1	biological_process	GO:0019344	cysteine biosynthetic process	"The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]	PANTHER
NV2t012844001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012844001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012844001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012845001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t012845001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012846001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t012846001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012846001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t012846001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t012846002.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t012849001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t012851001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t012851001.1	biological_process	GO:0048280	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	PANTHER
NV2t012851001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012855001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012855001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t012855001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t012855001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t012855001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t012855001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012855001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t012855001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012855001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012855002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012855002.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t012855002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012855003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012855003.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t012857001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012857001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012857001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t012858001.1	biological_process	GO:0061138	morphogenesis of a branching epithelium	"The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph]	InterPro
NV2t012858001.1	biological_process	GO:0061138	morphogenesis of a branching epithelium	"The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph]	OMA
NV2t012858001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012859001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012859002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t012861001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t012861001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t012861001.1	biological_process	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	OMA
NV2t012861001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t012861001.1	biological_process	GO:0051094	positive regulation of developmental process	"Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t012861001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t012861001.1	biological_process	GO:2000243	positive regulation of reproductive process	"Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah]	OMA
NV2t012861001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t012861001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t012861001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012861001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t012861001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t012861001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012861001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012861001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012861001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	OMA
NV2t012862001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t012862001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t012862001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t012862001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t012862001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t012862001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t012862001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012862001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t012862001.1	molecular_function	GO:0017069	snRNA binding	"Binding to a small nuclear RNA (snRNA)." [GOC:mah]	OMA
NV2t012862002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t012862002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012862003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t012862003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t012863001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t012863001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012863002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t012863002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t012863002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012863002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012864001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012864001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t012864001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t012864001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012864001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012866001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t012866001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t012866001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t012866001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t012866001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	InterPro
NV2t012866001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t012868001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012868002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012868002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012868002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t012869001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t012869001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t012869001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t012869001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t012869001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012869001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t012869001.1	molecular_function	GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	"Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]	InterPro
NV2t012869001.1	molecular_function	GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	"Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]	OMA
NV2t012869001.1	molecular_function	GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	"Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464]	PANTHER
NV2t012869001.1	molecular_function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate." [PMID:1698278, RHEA:66592]	OMA
NV2t012870001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t012870001.1	biological_process	GO:0046337	phosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732]	OMA
NV2t012870001.1	biological_process	GO:0046474	glycerophospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t012870001.1	biological_process	GO:0140042	lipid droplet formation	"A process that results in the assembly, arrangement of constituent parts of a lipid droplet." [PMID:28011631]	OMA
NV2t012870001.1	biological_process	GO:1901564	organonitrogen compound metabolic process	"The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t012870001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t012870001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t012870001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t012870001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t012870002.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t012870002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t012870003.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t012871001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t012871001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t012871001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t012871001.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t012871001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t012871001.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t012871001.1	molecular_function	GO:0033549	MAP kinase phosphatase activity	"Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316]	OMA
NV2t012871002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t012871002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t012871002.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t012871002.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t012871003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t012871003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t012871003.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t012871003.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t012871004.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t012871004.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t012871004.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t012871004.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t012872001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012872001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t012873001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012873001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t012873001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t012873001.1	cellular_component	GO:0035102	PRC1 complex	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]	OMA
NV2t012873001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	OMA
NV2t012873001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t012873002.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t012873003.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t012875001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t012875001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012875001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012875001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012875001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t012875001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t012875001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t012878001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878009.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012878010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878013.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878014.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878015.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878016.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878017.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t012878017.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878018.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t012878018.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878019.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012878020.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878021.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878022.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878023.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878024.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878025.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878026.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878027.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878028.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878029.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878030.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878032.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878033.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878034.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878035.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t012878035.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878036.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012878037.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012882001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t012882001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t012882001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012882001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t012883001.1	molecular_function	GO:0046976	histone H3K27 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein." [GOC:ai]	PANTHER
NV2t012883002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012883002.1	molecular_function	GO:0046976	histone H3K27 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein." [GOC:ai]	PANTHER
NV2t012883003.1	molecular_function	GO:0046976	histone H3K27 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein." [GOC:ai]	PANTHER
NV2t012884001.1	biological_process	GO:0019439	obsolete aromatic compound catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t012884001.1	biological_process	GO:0042167	heme catabolic process	"The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl]	InterPro
NV2t012884001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t012884001.1	biological_process	GO:0044270	obsolete cellular nitrogen compound catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t012884001.1	biological_process	GO:0046700	obsolete heterocycle catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]	OMA
NV2t012884001.1	biological_process	GO:1901361	organic cyclic compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t012884001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t012884001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t012884001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t012884001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t012885001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t012885001.1	biological_process	GO:0007140	male meiotic nuclear division	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw]	OMA
NV2t012885001.1	biological_process	GO:0007286	spermatid development	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]	OMA
NV2t012885001.1	biological_process	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	OMA
NV2t012885001.1	biological_process	GO:0009409	response to cold	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]	OMA
NV2t012885001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t012885001.1	biological_process	GO:0034620	cellular response to unfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]	OMA
NV2t012885001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t012885001.1	biological_process	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t012885001.1	biological_process	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t012885001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t012885001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012885001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012885001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t012885001.1	cellular_component	GO:0072687	meiotic spindle	"A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t012885001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t012885001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t012885001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t012885001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	OMA
NV2t012885001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t012885001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t012885001.1	molecular_function	GO:0097718	disordered domain specific binding	"Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698]	OMA
NV2t012885001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t012886001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t012886001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t012886001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t012887001.1	biological_process	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	OMA
NV2t012887001.1	biological_process	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	InterPro
NV2t012887002.1	biological_process	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	InterPro
NV2t012887003.1	biological_process	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	InterPro
NV2t012887004.1	biological_process	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	InterPro
NV2t012888001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t012888001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t012889001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012889001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t012890001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t012892001.1	biological_process	GO:0046890	regulation of lipid biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	PANTHER
NV2t012894001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t012895001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t012895002.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t012896001.1	biological_process	GO:0001764	neuron migration	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]	OMA
NV2t012896001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012896001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t012896001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t012897001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012897001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t012898001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012898002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t012898002.1	molecular_function	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]	OMA
NV2t012902001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t012902001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t012902001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012903006.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t012904001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t012905001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012908001.1	molecular_function	GO:0051427	hormone receptor binding	"Binding to a receptor for a hormone." [GOC:ai]	PANTHER
NV2t012908002.1	molecular_function	GO:0051427	hormone receptor binding	"Binding to a receptor for a hormone." [GOC:ai]	PANTHER
NV2t012912001.1	biological_process	GO:0003015	heart process	"A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]	OMA
NV2t012912001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	OMA
NV2t012912001.1	biological_process	GO:0015937	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	PANTHER
NV2t012912001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012912001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012912001.1	molecular_function	GO:0004632	phosphopantothenate--cysteine ligase activity	"Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5]	OMA
NV2t012912001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t012914001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t012914001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t012914001.1	molecular_function	GO:0003904	deoxyribodipyrimidine photo-lyase activity	"Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3]	PANTHER
NV2t012914001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t012914001.1	molecular_function	GO:0140097	catalytic activity, acting on DNA	"Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t012914002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t012914002.1	molecular_function	GO:0003904	deoxyribodipyrimidine photo-lyase activity	"Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3]	PANTHER
NV2t012920001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t012920001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012920001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t012920001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	OMA
NV2t012920001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	PANTHER
NV2t012920001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t012920001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t012920001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t012922001.1	molecular_function	GO:0030552	cAMP binding	"Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]	PANTHER
NV2t012923001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012923001.1	molecular_function	GO:0001609	G protein-coupled adenosine receptor activity	"Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]	OMA
NV2t012923001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t012924001.1	biological_process	GO:0061817	endoplasmic reticulum-plasma membrane tethering	"The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers." [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684]	InterPro
NV2t012924001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t012924001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t012924002.1	biological_process	GO:0061817	endoplasmic reticulum-plasma membrane tethering	"The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers." [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684]	InterPro
NV2t012924002.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t012924002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t012924003.1	biological_process	GO:0061817	endoplasmic reticulum-plasma membrane tethering	"The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers." [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684]	InterPro
NV2t012924003.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t012924003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t012925001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t012925001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t012925001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t012925001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t012925001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t012925001.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t012925001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t012925001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t012926001.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012926002.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012926003.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012926004.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012926005.1	biological_process	GO:0006166	purine ribonucleoside salvage	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]	InterPro
NV2t012926005.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012926006.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012926007.1	biological_process	GO:0006166	purine ribonucleoside salvage	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]	InterPro
NV2t012926007.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012926008.1	biological_process	GO:0006166	purine ribonucleoside salvage	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]	InterPro
NV2t012926008.1	biological_process	GO:0006188	IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732]	OMA
NV2t012926008.1	biological_process	GO:0009113	purine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732]	OMA
NV2t012926008.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t012926008.1	biological_process	GO:0046098	guanine metabolic process	"The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]	OMA
NV2t012926008.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012926008.1	biological_process	GO:0046128	purine ribonucleoside metabolic process	"The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]	OMA
NV2t012926008.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t012926008.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t012926008.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t012926009.1	biological_process	GO:0006166	purine ribonucleoside salvage	"Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]	InterPro
NV2t012926009.1	biological_process	GO:0046100	hypoxanthine metabolic process	"The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]	PANTHER
NV2t012927001.1	biological_process	GO:0018120	obsolete peptidyl-arginine ADP-ribosylation	"OBSOLETE. The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168]	PANTHER
NV2t012927001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t012927001.1	molecular_function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity	"Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide." [RHEA:19149]	InterPro
NV2t012927001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	OMA
NV2t012930001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t012930001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t012930001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t012939001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012939001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012939001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012940001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012940001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012940001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012942001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012942001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012942001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t012942001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012942001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t012943001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012943001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012943001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012943002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012943002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012943002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t012944001.1	cellular_component	GO:1990716	axonemal central apparatus	"Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]	PANTHER
NV2t012944001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012944002.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t012944002.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t012944002.1	cellular_component	GO:1990716	axonemal central apparatus	"Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]	PANTHER
NV2t012944002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012944002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t012945001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	InterPro
NV2t012945001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t012945001.1	biological_process	GO:0051014	actin filament severing	"The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]	OMA
NV2t012945001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t012945001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t012945001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t012945001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t012945001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012947001.1	molecular_function	GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25]	PANTHER
NV2t012947002.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t012947002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t012947002.1	molecular_function	GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25]	OMA
NV2t012947002.1	molecular_function	GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25]	PANTHER
NV2t012948001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t012948001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012948003.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t012948003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t012950001.1	cellular_component	GO:0008541	proteasome regulatory particle, lid subcomplex	"The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]	PANTHER
NV2t012955001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t012955001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t012959001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t012967001.1	biological_process	GO:0008643	carbohydrate transport	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]	OMA
NV2t012967001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t012967001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t012967001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t012967002.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t012969001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t012969001.1	biological_process	GO:2000641	regulation of early endosome to late endosome transport	"Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	InterPro
NV2t012969001.1	biological_process	GO:2000641	regulation of early endosome to late endosome transport	"Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	OMA
NV2t012970001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t012970001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012970001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t012972001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012972001.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	OMA
NV2t012972001.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t012972001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t012972001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t012973001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012973002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012973003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012973004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012973005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012973006.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012973007.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012973008.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t012987001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t012987001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t012987002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t012988001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t012988001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t012989001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t012989001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t012989001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t012989001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t012989001.1	molecular_function	GO:0015377	chloride:monoatomic cation symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [PMID:31747317]	OMA
NV2t012989001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t012990001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012990001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012990001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012990002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012990002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012990002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012990003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012990003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012990003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012990004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012990004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012990004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012990005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t012990005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t012990005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t012992001.1	biological_process	GO:1901098	positive regulation of autophagosome maturation	"Any process that activates or increases the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]	PANTHER
NV2t012992001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012992002.1	biological_process	GO:0072383	plus-end-directed vesicle transport along microtubule	"The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah]	OMA
NV2t012992002.1	biological_process	GO:1901098	positive regulation of autophagosome maturation	"Any process that activates or increases the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]	OMA
NV2t012992002.1	biological_process	GO:1901098	positive regulation of autophagosome maturation	"Any process that activates or increases the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]	PANTHER
NV2t012992002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t012992002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t012993001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t012993001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t012996001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012996001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t012996001.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	PANTHER
NV2t012999001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t012999001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013001001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t013001001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013001001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013002001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t013002001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t013002001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013002001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t013003001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t013003001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013003001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013006001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013006001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013006002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013006002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013006003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013006003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013008001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013008001.1	molecular_function	GO:0030332	cyclin binding	"Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]	PANTHER
NV2t013010001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013010001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t013010001.1	biological_process	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	OMA
NV2t013010001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t013010001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013010001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013010001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t013010001.1	molecular_function	GO:0005024	transforming growth factor beta receptor activity	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]	OMA
NV2t013010001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t013010001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013010001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013014001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t013014001.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t013014002.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t013014002.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t013014002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t013014002.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t013014002.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t013014002.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t013015001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t013015001.1	biological_process	GO:0034203	glycolipid translocation	"The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, PMID:11807558]	PANTHER
NV2t013015001.1	biological_process	GO:0034204	lipid translocation	"The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:mah]	OMA
NV2t013015001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t013015001.1	biological_process	GO:1901264	carbohydrate derivative transport	"The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie]	OMA
NV2t013015001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013015001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013020001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t013020001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t013020001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013020001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t013021001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t013043001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013043001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013053001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013053001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013054001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t013054001.1	biological_process	GO:0090168	Golgi reassembly	"The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t013054001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t013055001.1	biological_process	GO:0016180	snRNA processing	"Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres." [PMID:15196465, PMID:31815536]	OMA
NV2t013055001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t013056001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013058001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013058002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013059001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t013061001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013061002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013061002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013062001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013062001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013066001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013066001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013066001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t013069001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013069001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013070001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013070001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013074001.1	biological_process	GO:0019277	UDP-N-acetylgalactosamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]	InterPro
NV2t013074001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013074001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013076001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t013078001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t013078001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t013081001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013081001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t013086001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t013086001.1	molecular_function	GO:0031210	phosphatidylcholine binding	"Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t013086002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t013086002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013086003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013086004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013087001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t013087001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t013087001.1	molecular_function	GO:0031210	phosphatidylcholine binding	"Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t013087002.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t013087002.1	molecular_function	GO:0031210	phosphatidylcholine binding	"Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t013089001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013089001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t013090001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013090001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013090001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t013091001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013091001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t013091001.1	molecular_function	GO:0017108	5'-flap endonuclease activity	"Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]	PANTHER
NV2t013094001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013094001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t013094001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t013094001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t013094001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t013094001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013095001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t013095001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t013095001.1	biological_process	GO:0030206	chondroitin sulfate biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]	OMA
NV2t013095001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013095001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t013096001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013096001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t013096001.1	biological_process	GO:0008361	regulation of cell size	"Any process that modulates the size of a cell." [GOC:go_curators]	OMA
NV2t013096001.1	biological_process	GO:0008361	regulation of cell size	"Any process that modulates the size of a cell." [GOC:go_curators]	PANTHER
NV2t013096001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013096001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013096001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t013096001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013096001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013096002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013096002.1	biological_process	GO:0008361	regulation of cell size	"Any process that modulates the size of a cell." [GOC:go_curators]	PANTHER
NV2t013096002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013096003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013096003.1	biological_process	GO:0008361	regulation of cell size	"Any process that modulates the size of a cell." [GOC:go_curators]	PANTHER
NV2t013096003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013096004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013096004.1	biological_process	GO:0008361	regulation of cell size	"Any process that modulates the size of a cell." [GOC:go_curators]	PANTHER
NV2t013096004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013096005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013096005.1	biological_process	GO:0008361	regulation of cell size	"Any process that modulates the size of a cell." [GOC:go_curators]	PANTHER
NV2t013096005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013096006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013096006.1	biological_process	GO:0008361	regulation of cell size	"Any process that modulates the size of a cell." [GOC:go_curators]	PANTHER
NV2t013096006.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013098001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t013098001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t013098001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t013098001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013098001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t013098001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t013098001.1	cellular_component	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	OMA
NV2t013098001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013098001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t013098001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013100001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013100001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013102001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t013102001.1	biological_process	GO:0016242	negative regulation of macroautophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]	OMA
NV2t013102001.1	biological_process	GO:0031929	TOR signaling	"The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]	OMA
NV2t013102001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013102001.1	cellular_component	GO:0031931	TORC1 complex	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t013102001.1	cellular_component	GO:0031932	TORC2 complex	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t013102001.1	cellular_component	GO:0031932	TORC2 complex	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]	PANTHER
NV2t013102001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t013102001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t013102001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013102001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t013102001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	InterPro
NV2t013102001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t013103001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t013103002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t013104001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t013104001.1	biological_process	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t013104001.1	biological_process	GO:0070071	proton-transporting two-sector ATPase complex assembly	"The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane." [GOC:mah]	OMA
NV2t013104001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t013108001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t013108001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013109001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	InterPro
NV2t013109001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t013109001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t013109001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t013109001.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t013109001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t013109001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	OMA
NV2t013109001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t013111001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t013111001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t013112001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013112001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t013112002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013112002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013112003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013112003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013116001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013116001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013116002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013116002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013116003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013116003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013116004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013116004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013119001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	PANTHER
NV2t013119001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013119001.1	molecular_function	GO:0140492	metal-dependent deubiquitinase activity	"An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [PMID:19489724]	InterPro
NV2t013119002.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	PANTHER
NV2t013119002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013119002.1	molecular_function	GO:0140492	metal-dependent deubiquitinase activity	"An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [PMID:19489724]	InterPro
NV2t013119003.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	PANTHER
NV2t013119003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013119003.1	molecular_function	GO:0140492	metal-dependent deubiquitinase activity	"An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [PMID:19489724]	InterPro
NV2t013119004.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	PANTHER
NV2t013119004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013119004.1	molecular_function	GO:0140492	metal-dependent deubiquitinase activity	"An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [PMID:19489724]	InterPro
NV2t013119005.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	OMA
NV2t013119005.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	PANTHER
NV2t013119005.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t013119005.1	cellular_component	GO:0032154	cleavage furrow	"The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409]	OMA
NV2t013119005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013119005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013119005.1	molecular_function	GO:0061578	K63-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin." [GOC:dph, GOC:pg, PMID:18313383]	OMA
NV2t013119005.1	molecular_function	GO:0140492	metal-dependent deubiquitinase activity	"An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [PMID:19489724]	InterPro
NV2t013119006.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	PANTHER
NV2t013119006.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013119006.1	molecular_function	GO:0140492	metal-dependent deubiquitinase activity	"An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [PMID:19489724]	InterPro
NV2t013120001.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	InterPro
NV2t013120002.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	InterPro
NV2t013120003.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	InterPro
NV2t013121001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013121001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013121002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013121002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013121003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013121003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013121004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013121004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013121005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013121005.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013121006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013121006.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013121007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013121007.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013122001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013122001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	PANTHER
NV2t013122002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013122002.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	PANTHER
NV2t013122003.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t013122003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013122003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013122003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t013122003.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	PANTHER
NV2t013123001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t013123001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013123001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t013123001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013123001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t013123001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t013123001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t013123001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t013123001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t013123002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013123002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013123002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t013123002.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t013123002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t013124001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013124001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	PANTHER
NV2t013126001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013126001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013126001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013126001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013128001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013128001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013128001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013132001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t013133001.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	PANTHER
NV2t013133001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013133001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t013136001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013136001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t013136001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013136002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013136002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013136003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013137001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013137001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013137001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t013137001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013137001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013137001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013138001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013138001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013138001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013139001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t013139001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	PANTHER
NV2t013139001.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t013139001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t013139001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t013140001.1	biological_process	GO:0015837	amine transport	"The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]	OMA
NV2t013140001.1	biological_process	GO:0015850	organic hydroxy compound transport	"The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]	OMA
NV2t013140001.1	biological_process	GO:0019755	one-carbon compound transport	"The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t013140001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t013140001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013140001.1	biological_process	GO:0072531	pyrimidine-containing compound transmembrane transport	"The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t013140001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t013140001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	PANTHER
NV2t013140001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t013140001.1	molecular_function	GO:0005345	purine nucleobase transmembrane transporter activity	"Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t013140001.1	molecular_function	GO:0015144	carbohydrate transmembrane transporter activity	"Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013140001.1	molecular_function	GO:0015250	water channel activity	"Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013140001.1	molecular_function	GO:0042887	amide transmembrane transporter activity	"Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]	OMA
NV2t013140001.1	molecular_function	GO:1901618	organic hydroxy compound transmembrane transporter activity	"Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t013140002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013140002.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	PANTHER
NV2t013141001.1	biological_process	GO:0015850	organic hydroxy compound transport	"The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]	OMA
NV2t013141001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013141001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t013141001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	PANTHER
NV2t013141001.1	molecular_function	GO:0015144	carbohydrate transmembrane transporter activity	"Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013141001.1	molecular_function	GO:0015250	water channel activity	"Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013141001.1	molecular_function	GO:1901618	organic hydroxy compound transmembrane transporter activity	"Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t013141002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013141002.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	PANTHER
NV2t013142001.1	biological_process	GO:0042421	norepinephrine biosynthetic process	"The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t013142001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013142001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t013142001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t013142001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t013142002.1	biological_process	GO:0042421	norepinephrine biosynthetic process	"The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t013142002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013142002.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t013142003.1	biological_process	GO:0042421	norepinephrine biosynthetic process	"The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t013142003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013142003.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t013142004.1	biological_process	GO:0042421	norepinephrine biosynthetic process	"The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t013144001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013144001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	InterPro
NV2t013144001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013147001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013147001.1	biological_process	GO:0035025	positive regulation of Rho protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	OMA
NV2t013147001.1	biological_process	GO:0051482	obsolete positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	"OBSOLETE. Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol." [GOC:ai, GOC:signaling]	OMA
NV2t013147001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013147001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013147001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013147002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013147002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013147003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013147003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013147004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013147004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013147005.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013147005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013149001.1	biological_process	GO:0006741	NADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	InterPro
NV2t013149001.1	biological_process	GO:0006741	NADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	PANTHER
NV2t013149001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	InterPro
NV2t013149002.1	biological_process	GO:0006741	NADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	InterPro
NV2t013149002.1	biological_process	GO:0006741	NADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	PANTHER
NV2t013149002.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	InterPro
NV2t013149003.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t013149003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013149003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013149004.1	biological_process	GO:0006741	NADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	InterPro
NV2t013149004.1	biological_process	GO:0006741	NADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	PANTHER
NV2t013149004.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	InterPro
NV2t013149005.1	biological_process	GO:0006741	NADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	InterPro
NV2t013149005.1	biological_process	GO:0006741	NADP biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	PANTHER
NV2t013149005.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	InterPro
NV2t013150001.1	biological_process	GO:0032963	collagen metabolic process	"The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013150001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t013150002.1	biological_process	GO:0032963	collagen metabolic process	"The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013150002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t013150002.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t013150002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013150002.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t013150002.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t013150002.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t013150002.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t013150002.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t013150002.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t013150002.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t013150003.1	biological_process	GO:0032963	collagen metabolic process	"The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013150003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013150003.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t013151001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013151001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013151002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013151002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013160001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013160002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013162001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t013162001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013162001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013162003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013162004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013163001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t013164001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t013168001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013168002.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013168003.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013169001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013170001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013171001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t013172001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013172002.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013172003.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013172004.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	PANTHER
NV2t013182001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013182001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t013183001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t013183002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t013186001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t013186001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013187001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t013187001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013188001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t013188001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t013188001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t013188001.1	biological_process	GO:0010039	response to iron ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm]	OMA
NV2t013188001.1	biological_process	GO:0072350	tricarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [GOC:mah]	OMA
NV2t013188001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013188001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013188001.1	molecular_function	GO:0003994	aconitate hydratase activity	"Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw]	OMA
NV2t013188001.1	molecular_function	GO:0030350	iron-responsive element binding	"Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843]	OMA
NV2t013188001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t013188001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t013188002.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t013188003.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t013188004.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t013189001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013189002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013189002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013190001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t013190001.1	molecular_function	GO:0016151	nickel cation binding	"Binding to a nickel (Ni) cation." [GOC:ai]	InterPro
NV2t013190001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t013192001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t013192001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t013192001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013193001.1	biological_process	GO:0000245	spliceosomal complex assembly	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]	OMA
NV2t013193001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t013193001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t013193001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t013193002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t013194001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	OMA
NV2t013194001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t013195001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013196001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t013196001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t013196001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t013196001.1	biological_process	GO:0022414	reproductive process	"A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]	OMA
NV2t013196001.1	biological_process	GO:0030866	cortical actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:pf]	OMA
NV2t013196001.1	biological_process	GO:0032989	cellular anatomical entity morphogenesis	"The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t013196001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t013196001.1	biological_process	GO:0099188	postsynaptic cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]	OMA
NV2t013196001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t013196001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013196001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t013196001.1	cellular_component	GO:0030863	cortical cytoskeleton	"The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]	OMA
NV2t013196001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	OMA
NV2t013196001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t013196001.1	cellular_component	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t013196001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t013196001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t013198001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	PANTHER
NV2t013198002.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	PANTHER
NV2t013201001.1	biological_process	GO:0006656	phosphatidylcholine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732]	OMA
NV2t013201001.1	biological_process	GO:0006658	phosphatidylserine metabolic process	"The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t013201001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t013201001.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	OMA
NV2t013201001.1	biological_process	GO:0032370	positive regulation of lipid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t013201001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t013201001.1	biological_process	GO:0036335	intestinal stem cell homeostasis	"Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863, PMID:22608824]	OMA
NV2t013201001.1	biological_process	GO:0045862	positive regulation of proteolysis	"Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	OMA
NV2t013201001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t013201001.1	biological_process	GO:0050728	negative regulation of inflammatory response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]	OMA
NV2t013201001.1	biological_process	GO:0050810	regulation of steroid biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai]	OMA
NV2t013201001.1	biological_process	GO:0060456	positive regulation of digestive system process	"Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]	OMA
NV2t013201001.1	biological_process	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t013201001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t013201001.1	biological_process	GO:0070613	regulation of protein processing	"Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah]	OMA
NV2t013201001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t013201001.1	biological_process	GO:0090158	endoplasmic reticulum membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t013201001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013201001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t013201001.1	molecular_function	GO:0071617	lysophospholipid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]	OMA
NV2t013201001.1	molecular_function	GO:0071617	lysophospholipid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]	PANTHER
NV2t013203001.1	molecular_function	GO:0071617	lysophospholipid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]	PANTHER
NV2t013204001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013204001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t013204001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013204001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013204001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t013207001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t013207001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013207001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013208001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t013208001.1	biological_process	GO:0022904	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	OMA
NV2t013208001.1	cellular_component	GO:0005746	mitochondrial respirasome	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]	OMA
NV2t013208001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t013208001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t013208001.1	cellular_component	GO:0098803	respiratory chain complex	"Any protein complex that is part of a respiratory chain." [GOC:dos]	OMA
NV2t013208001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t013208001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t013208001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013208001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t013208001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t013208001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t013208001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t013210001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013210001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	InterPro
NV2t013210001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013210001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t013210002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013210002.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	InterPro
NV2t013210002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013210003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013210003.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	InterPro
NV2t013210003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013210003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013210003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t013212001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t013212001.1	biological_process	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	OMA
NV2t013212001.1	biological_process	GO:0035304	regulation of protein dephosphorylation	"Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	OMA
NV2t013212001.1	biological_process	GO:0035306	positive regulation of dephosphorylation	"Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]	OMA
NV2t013212001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t013212001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013212001.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t013212001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t013212001.1	molecular_function	GO:0004865	protein serine/threonine phosphatase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb]	OMA
NV2t013212001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013212001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t013213001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t013213001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t013213001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013213001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t013213001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t013213001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t013213001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t013213001.1	molecular_function	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]	InterPro
NV2t013214001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t013214001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013214001.1	biological_process	GO:0051490	negative regulation of filopodium assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai]	PANTHER
NV2t013216001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	InterPro
NV2t013218001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013218001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013218002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013218002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013218003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013218003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013220001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t013221001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t013221001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013221001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t013221001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t013221001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013222001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013222001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013222001.1	molecular_function	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	InterPro
NV2t013222001.1	molecular_function	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t013222001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t013222001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t013222001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t013223001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t013223001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t013223001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013223001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013223001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013223001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013223001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t013224001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t013224001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013224002.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t013224002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013224002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013224002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013225001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013225001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t013225001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013225001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013232001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013232001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t013232002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t013232002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013232002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013234001.1	biological_process	GO:0043041	amino acid activation for nonribosomal peptide biosynthetic process	"Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl]	OMA
NV2t013234001.1	biological_process	GO:0044550	secondary metabolite biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]	OMA
NV2t013234001.1	biological_process	GO:0044550	secondary metabolite biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]	PANTHER
NV2t013234001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013234001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t013234001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t013234001.1	molecular_function	GO:0072341	modified amino acid binding	"Binding to a modified amino acid." [GOC:mah]	OMA
NV2t013235001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t013235001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013235001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013235001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t013235001.1	molecular_function	GO:0005537	mannose binding	"Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [GOC:jl, ISBN:0192800981]	OMA
NV2t013237002.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t013237002.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t013237002.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t013241001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013242001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t013242001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t013242001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t013243002.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t013243002.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013243003.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t013243003.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013243004.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t013243004.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013246001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013250001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t013250001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t013250001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t013250001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t013250001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013250001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013250001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013250001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t013250002.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t013250002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013250002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013250003.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t013250003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013250003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013250004.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t013250004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013250004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013250005.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t013250005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013250005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013250006.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t013250006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013250006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013251001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013251001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013252001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013252002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013253001.1	cellular_component	GO:1990429	peroxisomal importomer complex	"A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:12667447, PMID:20154681, PMID:22375831]	PANTHER
NV2t013253002.1	cellular_component	GO:1990429	peroxisomal importomer complex	"A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:12667447, PMID:20154681, PMID:22375831]	PANTHER
NV2t013253003.1	cellular_component	GO:1990429	peroxisomal importomer complex	"A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:12667447, PMID:20154681, PMID:22375831]	PANTHER
NV2t013253005.1	cellular_component	GO:1990429	peroxisomal importomer complex	"A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:12667447, PMID:20154681, PMID:22375831]	PANTHER
NV2t013254001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t013255001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013255001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t013255001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t013255001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013255001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t013256001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013256001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t013256001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t013256001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t013256001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t013256001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013256001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t013257001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013257001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013259001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013259001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013259001.1	biological_process	GO:0016486	peptide hormone processing	"The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah]	OMA
NV2t013259001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t013259001.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t013259001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t013259001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013259001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013259001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013259002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013259002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013259002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013259003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013259003.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013259003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013259004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013259004.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013259004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013260001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t013260001.1	biological_process	GO:0031125	rRNA 3'-end processing	"Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah]	OMA
NV2t013260001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t013260001.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t013260001.1	cellular_component	GO:0000176	nuclear exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t013260001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t013260001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t013260001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013260001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t013260001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t013260002.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t013260002.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t013260002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013260002.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t013263001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013263001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013263002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013263002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013263003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013263003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013263004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013263004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013264002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013265001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013268001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013268001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013268001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013268001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013268001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013268001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013270001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013270001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013272001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t013272001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t013272001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t013272001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013273001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t013273001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013273002.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t013273002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013274001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t013274001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013274002.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t013274002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013275001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t013275001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013275002.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t013275002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013275003.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t013275003.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013275003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013275003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013276001.1	biological_process	GO:0031591	wybutosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]	PANTHER
NV2t013277001.1	biological_process	GO:0031591	wybutosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]	PANTHER
NV2t013283001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013283001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013286001.1	biological_process	GO:0006857	oligopeptide transport	"The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732]	OMA
NV2t013286001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013286001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t013286001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013286001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013286001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013287001.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t013287002.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t013287003.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t013287004.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	InterPro
NV2t013292001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013292001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013292001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013292001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013293001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t013293001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013293001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013293001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013293001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013293001.1	molecular_function	GO:0048018	receptor ligand activity	"The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]	PANTHER
NV2t013293002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013293002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013294001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t013294001.1	biological_process	GO:0006998	nuclear envelope organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]	OMA
NV2t013294001.1	biological_process	GO:0010867	positive regulation of triglyceride biosynthetic process	"Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]	OMA
NV2t013294001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013294001.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t013294001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t013294001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t013294001.1	molecular_function	GO:0004721	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]	PANTHER
NV2t013294001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t013294001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t013295001.1	biological_process	GO:0000038	very long-chain fatty acid metabolic process	"The chemical reactions and pathways involving a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [GOC:hjd]	OMA
NV2t013295001.1	biological_process	GO:0001881	receptor recycling	"The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph]	OMA
NV2t013295001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t013295001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	InterPro
NV2t013295001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	OMA
NV2t013295001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t013295001.1	biological_process	GO:1990928	response to amino acid starvation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [PMID:7765311]	OMA
NV2t013295001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t013295001.1	cellular_component	GO:0016593	Cdc73/Paf1 complex	"A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]	OMA
NV2t013295001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013295001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t013295001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t013296001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t013296001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t013296001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t013296001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t013296001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t013296001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t013296001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t013296001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013296001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013296001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t013296002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t013296002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013296003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t013296003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013297001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013297001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t013297001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t013297001.1	molecular_function	GO:0004558	alpha-1,4-glucosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20]	PANTHER
NV2t013297001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t013297001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t013302001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t013302001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t013302001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t013302001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t013302001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t013302001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t013302001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t013302001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t013303001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013303001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013304001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013304001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013304001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t013305001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t013305001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t013305001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t013306001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013306001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	PANTHER
NV2t013306001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013306001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t013306002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013306002.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	PANTHER
NV2t013306002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t013308001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t013308001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t013308001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t013308001.1	biological_process	GO:0010634	positive regulation of epithelial cell migration	"Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t013308001.1	biological_process	GO:0014065	obsolete phosphatidylinositol 3-kinase signaling	"OBSOLETE. A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, PMID:22525052, Wikipedia:PI3K]	OMA
NV2t013308001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t013308001.1	biological_process	GO:0031324	negative regulation of cellular metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t013308001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t013308001.1	biological_process	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t013308001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t013308001.1	biological_process	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t013308001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t013308001.1	biological_process	GO:0071900	regulation of protein serine/threonine kinase activity	"Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t013308001.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t013308001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013308001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013308001.1	cellular_component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	"A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495]	OMA
NV2t013308001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t013308001.1	molecular_function	GO:0016303	1-phosphatidylinositol-3-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+." [EC:2.7.1.137, RHEA:12709]	OMA
NV2t013308001.1	molecular_function	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+." [EC:2.7.1.154, RHEA:18373]	OMA
NV2t013308001.1	molecular_function	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+." [EC:2.7.1.153, RHEA:21292]	OMA
NV2t013308001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	PANTHER
NV2t013310001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t013310001.1	biological_process	GO:0090150	establishment of protein localization to membrane	"The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t013310001.1	biological_process	GO:0140570	extraction of mislocalized protein from mitochondrial outer membrane	"The removal of a mislocalized protein from the mitochondrial outer membrane." [PMID:32973005]	PANTHER
NV2t013310001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t013310001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t013310001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013310001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013310001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t013310002.1	biological_process	GO:0140570	extraction of mislocalized protein from mitochondrial outer membrane	"The removal of a mislocalized protein from the mitochondrial outer membrane." [PMID:32973005]	PANTHER
NV2t013310002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013311001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t013311001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t013311001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t013311001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t013311001.1	biological_process	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	OMA
NV2t013311001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t013311001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t013311001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t013311001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t013311001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t013311001.1	molecular_function	GO:0048027	mRNA 5'-UTR binding	"Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]	OMA
NV2t013312001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t013312001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	OMA
NV2t013312001.1	biological_process	GO:0070813	hydrogen sulfide metabolic process	"The chemical reactions and pathways involving hydrogen sulfide, H2S." [GOC:mah]	PANTHER
NV2t013312001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013312001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t013312001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t013312001.1	molecular_function	GO:0050313	sulfur dioxygenase activity	"Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+." [EC:1.13.11.18]	InterPro
NV2t013312002.1	biological_process	GO:0070813	hydrogen sulfide metabolic process	"The chemical reactions and pathways involving hydrogen sulfide, H2S." [GOC:mah]	PANTHER
NV2t013312002.1	molecular_function	GO:0050313	sulfur dioxygenase activity	"Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+." [EC:1.13.11.18]	InterPro
NV2t013312003.1	biological_process	GO:0070813	hydrogen sulfide metabolic process	"The chemical reactions and pathways involving hydrogen sulfide, H2S." [GOC:mah]	PANTHER
NV2t013312003.1	molecular_function	GO:0050313	sulfur dioxygenase activity	"Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+." [EC:1.13.11.18]	InterPro
NV2t013312004.1	biological_process	GO:0070813	hydrogen sulfide metabolic process	"The chemical reactions and pathways involving hydrogen sulfide, H2S." [GOC:mah]	PANTHER
NV2t013312004.1	molecular_function	GO:0050313	sulfur dioxygenase activity	"Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+." [EC:1.13.11.18]	InterPro
NV2t013313001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t013313001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013313001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t013313001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t013313001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t013313001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t013313001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t013313001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t013314001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013314001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013314001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013314001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013314002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013314002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013318001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013318001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013321001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t013321001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t013321001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013321001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013321001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013321001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013323001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t013323001.1	molecular_function	GO:0016776	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	OMA
NV2t013323001.1	molecular_function	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity	"Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate." [EC:2.7.4.24]	PANTHER
NV2t013324001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t013324001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t013324001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t013324001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t013324001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t013324001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013330001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t013330001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t013330001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013330001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013330001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013330001.1	molecular_function	GO:0046875	ephrin receptor binding	"Binding to an ephrin receptor." [GOC:ai]	OMA
NV2t013330002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013330002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013330003.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013330003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013330004.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013330004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013330005.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013330005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013330006.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013330006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013331001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013331001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t013331001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t013332001.1	biological_process	GO:1903078	positive regulation of protein localization to plasma membrane	"Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]	PANTHER
NV2t013332001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013332002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013333001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t013333001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013334001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t013334001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013334001.1	cellular_component	GO:0030125	clathrin vesicle coat	"A clathrin coat found on a vesicle." [GOC:mah]	OMA
NV2t013334001.1	cellular_component	GO:0030125	clathrin vesicle coat	"A clathrin coat found on a vesicle." [GOC:mah]	PANTHER
NV2t013336001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013336001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t013336001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013336001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t013339001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013339001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013340001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013340001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013340002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013343001.1	biological_process	GO:0009234	menaquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]	OMA
NV2t013343001.1	biological_process	GO:0042362	fat-soluble vitamin biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]	OMA
NV2t013343001.1	biological_process	GO:0042371	vitamin K biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]	PANTHER
NV2t013343001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t013343001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t013343001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	InterPro
NV2t013343001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t013343001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013345001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	OMA
NV2t013345001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013345001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t013350001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t013350001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013351001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t013351001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t013351001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013353001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t013353001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t013353001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013354001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013354001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t013361001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t013361001.1	biological_process	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	OMA
NV2t013361001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013361001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013361001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t013361001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t013361001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t013362001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013362001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t013362001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t013365001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013365001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	PANTHER
NV2t013365001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013367001.1	biological_process	GO:1903189	glyoxal metabolic process	"The chemical reactions and pathways involving glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie]	PANTHER
NV2t013367002.1	biological_process	GO:0006725	obsolete cellular aromatic compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732]	OMA
NV2t013367002.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t013367002.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t013367002.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	OMA
NV2t013367002.1	biological_process	GO:0034308	primary alcohol metabolic process	"The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]	OMA
NV2t013367002.1	biological_process	GO:0042180	cellular ketone metabolic process	"The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]	OMA
NV2t013367002.1	biological_process	GO:0042592	homeostatic process	"Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]	OMA
NV2t013367002.1	biological_process	GO:0046165	alcohol biosynthetic process	"The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]	OMA
NV2t013367002.1	biological_process	GO:0046185	aldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t013367002.1	biological_process	GO:0071310	cellular response to organic substance	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah]	OMA
NV2t013367002.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t013367002.1	biological_process	GO:1901215	obsolete negative regulation of neuron death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t013367002.1	biological_process	GO:1901360	organic cyclic compound metabolic process	"The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]	OMA
NV2t013367002.1	biological_process	GO:1901564	organonitrogen compound metabolic process	"The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t013367002.1	biological_process	GO:1901655	cellular response to ketone	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t013367002.1	biological_process	GO:1903189	glyoxal metabolic process	"The chemical reactions and pathways involving glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie]	PANTHER
NV2t013367002.1	biological_process	GO:1990748	cellular detoxification	"Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw]	OMA
NV2t013367002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013367002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013367002.1	molecular_function	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t013367002.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t013367002.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t013368001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013368001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013368001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t013368001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013368001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013369001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t013369001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t013369001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013369002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t013369002.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t013369002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013369002.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t013369002.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013370001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013370001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013370002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013370003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013370003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013370003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013370004.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013371001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t013371001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013371002.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t013371002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013371003.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t013371003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013372001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013372001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013372001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013372001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013372002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013372002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013372003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013372003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013372004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013372004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013372005.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013372005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013372006.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013372006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013372007.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013372007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013372008.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013372008.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013376001.1	biological_process	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	OMA
NV2t013376001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t013376001.1	biological_process	GO:0034641	obsolete cellular nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah]	OMA
NV2t013376001.1	biological_process	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]	OMA
NV2t013376001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013376001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013376001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t013378001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	OMA
NV2t013378001.1	biological_process	GO:0006605	protein targeting	"The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	OMA
NV2t013378001.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t013378001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013378001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t013378001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013378001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013378001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t013378001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t013378001.1	cellular_component	GO:1905368	peptidase complex	"A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	OMA
NV2t013381001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t013383001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t013383001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t013384001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t013384001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t013384001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t013385001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t013386001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013386001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013386001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013388001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013388001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t013388001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t013390001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	PANTHER
NV2t013392001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t013393001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013395001.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	OMA
NV2t013395001.1	biological_process	GO:0016559	peroxisome fission	"The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]	InterPro
NV2t013395001.1	biological_process	GO:0016559	peroxisome fission	"The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]	PANTHER
NV2t013395001.1	biological_process	GO:0048285	organelle fission	"The creation of two or more organelles by division of one organelle." [GOC:jid]	OMA
NV2t013395001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t013399001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013400001.1	biological_process	GO:0006545	glycine biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators]	OMA
NV2t013400001.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	OMA
NV2t013400001.1	biological_process	GO:0006767	water-soluble vitamin metabolic process	"The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl]	OMA
NV2t013400001.1	biological_process	GO:0031103	axon regeneration	"The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]	OMA
NV2t013400001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t013400001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t013400001.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t013400001.1	biological_process	GO:0046653	tetrahydrofolate metabolic process	"The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	OMA
NV2t013400001.1	biological_process	GO:0046654	tetrahydrofolate biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	InterPro
NV2t013400001.1	biological_process	GO:0051353	positive regulation of oxidoreductase activity	"Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]	OMA
NV2t013400001.1	biological_process	GO:2000121	regulation of removal of superoxide radicals	"Any process that modulates the frequency, rate or extent of removal of superoxide radicals." [GOC:obol]	OMA
NV2t013400001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013400001.1	molecular_function	GO:0000900	mRNA regulatory element binding translation repressor activity	"Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370]	OMA
NV2t013400001.1	molecular_function	GO:0004146	dihydrofolate reductase activity	"Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]	InterPro
NV2t013400001.1	molecular_function	GO:0004146	dihydrofolate reductase activity	"Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]	OMA
NV2t013400001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t013400001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t013400001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t013400001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t013400001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t013400001.1	molecular_function	GO:0072341	modified amino acid binding	"Binding to a modified amino acid." [GOC:mah]	OMA
NV2t013400001.1	molecular_function	GO:1990825	sequence-specific mRNA binding	"Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]	OMA
NV2t013400002.1	biological_process	GO:0046654	tetrahydrofolate biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	InterPro
NV2t013400002.1	molecular_function	GO:0004146	dihydrofolate reductase activity	"Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]	InterPro
NV2t013400002.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t013400003.1	biological_process	GO:0046654	tetrahydrofolate biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	InterPro
NV2t013400003.1	molecular_function	GO:0004146	dihydrofolate reductase activity	"Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]	InterPro
NV2t013400003.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t013400004.1	biological_process	GO:0046654	tetrahydrofolate biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	InterPro
NV2t013400004.1	molecular_function	GO:0004146	dihydrofolate reductase activity	"Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]	InterPro
NV2t013400004.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t013400005.1	biological_process	GO:0046654	tetrahydrofolate biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	InterPro
NV2t013400005.1	molecular_function	GO:0004146	dihydrofolate reductase activity	"Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]	InterPro
NV2t013400005.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t013401001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013401001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t013402001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013402001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t013402001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t013402001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t013402001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013404001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t013404001.1	biological_process	GO:0009068	aspartate family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t013404001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013404001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013404001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t013404001.1	molecular_function	GO:0008890	glycine C-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA." [EC:2.3.1.29, RHEA:20736]	InterPro
NV2t013404001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t013404001.1	molecular_function	GO:0016408	C-acyltransferase activity	"Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]	OMA
NV2t013404001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t013404001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013404001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t013407001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013407001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013407001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013408001.1	biological_process	GO:0000338	protein deneddylation	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]	OMA
NV2t013408001.1	biological_process	GO:0010387	COP9 signalosome assembly	"The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927]	InterPro
NV2t013408001.1	biological_process	GO:0010387	COP9 signalosome assembly	"The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927]	OMA
NV2t013408001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	OMA
NV2t013408001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t013410001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013412001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013412001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013412001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013412001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013412001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013412001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013413001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t013413001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013414001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t013414001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t013414001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t013414001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t013414001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t013415001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t013415001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t013415001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t013415001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	OMA
NV2t013415001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	PANTHER
NV2t013415001.1	biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]	OMA
NV2t013415001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013415001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t013415001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t013417001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013421001.1	molecular_function	GO:0004500	dopamine beta-monooxygenase activity	"Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]	InterPro
NV2t013422001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013422001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013422002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013423001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t013423001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t013423001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t013423001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013423001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t013424001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013424001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t013424001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	InterPro
NV2t013424001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t013424001.1	molecular_function	GO:0008422	beta-glucosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21, PMID:12594539]	PANTHER
NV2t013426001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013426001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t013427001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t013427001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013427001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t013429001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t013429001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013430001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	PANTHER
NV2t013431001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t013431001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013431002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t013431002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013431003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t013433001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013433001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t013437001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t013437001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013438001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	PANTHER
NV2t013438002.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t013438002.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	PANTHER
NV2t013438002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013438002.1	cellular_component	GO:0031082	BLOC complex	"Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680]	OMA
NV2t013442001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013443001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013443001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013443001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013445001.1	biological_process	GO:0070920	regulation of regulatory ncRNA processing	"Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing." [GOC:mah]	PANTHER
NV2t013450001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t013451001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	OMA
NV2t013451001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t013451001.1	molecular_function	GO:0004527	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	InterPro
NV2t013451001.1	molecular_function	GO:0008409	5'-3' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai]	InterPro
NV2t013451001.1	molecular_function	GO:0008409	5'-3' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai]	OMA
NV2t013451002.1	molecular_function	GO:0004527	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	InterPro
NV2t013453001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t013453001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013453001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013454001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013454002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013455001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t013455001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t013455001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t013455001.1	biological_process	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	OMA
NV2t013455001.1	biological_process	GO:0031331	positive regulation of cellular catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t013455001.1	biological_process	GO:0031396	regulation of protein ubiquitination	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t013455001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t013455001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t013455001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013455001.1	cellular_component	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t013455001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t013455001.1	molecular_function	GO:0050811	GABA receptor binding	"Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai]	OMA
NV2t013455001.1	molecular_function	GO:0050811	GABA receptor binding	"Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai]	PANTHER
NV2t013456002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013457001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t013460001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013462001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013462001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013462001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t013462002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013463005.1	biological_process	GO:0010457	centriole-centriole cohesion	"The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]	OMA
NV2t013463005.1	biological_process	GO:0032053	ciliary basal body organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124]	OMA
NV2t013463005.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t013463005.1	biological_process	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	OMA
NV2t013463005.1	biological_process	GO:0045724	positive regulation of cilium assembly	"Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]	OMA
NV2t013463005.1	biological_process	GO:1903829	positive regulation of protein localization	"Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t013463005.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t013463005.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t013463005.1	cellular_component	GO:0035253	ciliary rootlet	"A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]	OMA
NV2t013463005.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t013463005.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	OMA
NV2t013464001.1	biological_process	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t013464001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t013464001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013464001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t013464001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t013465001.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	OMA
NV2t013465001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t013465001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t013465001.1	biological_process	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]	OMA
NV2t013465001.1	biological_process	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t013465001.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t013465001.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t013465001.1	biological_process	GO:1901360	organic cyclic compound metabolic process	"The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie]	OMA
NV2t013465001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t013465001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013465001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013465001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013465001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013465002.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t013465002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013465002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013465003.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t013465003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013465004.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t013465004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013465004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013466001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t013466001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t013466001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013466001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013466001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t013466001.1	molecular_function	GO:0004298	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013469001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t013469001.1	biological_process	GO:0034227	tRNA thio-modification	"The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]	InterPro
NV2t013469001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013469001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t013469001.1	molecular_function	GO:0016783	sulfurtransferase activity	"Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544]	OMA
NV2t013470001.1	biological_process	GO:0036066	protein O-linked fucosylation	"The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734]	OMA
NV2t013470001.1	biological_process	GO:0036085	GDP-fucose import into Golgi lumen	"The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]	OMA
NV2t013470001.1	biological_process	GO:0036085	GDP-fucose import into Golgi lumen	"The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]	PANTHER
NV2t013470001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t013470001.1	molecular_function	GO:0005457	GDP-fucose transmembrane transporter activity	"Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013470001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t013473001.1	biological_process	GO:0000423	mitophagy	"The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367]	OMA
NV2t013473001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t013473001.1	biological_process	GO:0002702	positive regulation of production of molecular mediator of immune response	"Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]	OMA
NV2t013473001.1	biological_process	GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	"The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438]	OMA
NV2t013473001.1	biological_process	GO:0003006	developmental process involved in reproduction	"A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]	OMA
NV2t013473001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t013473001.1	biological_process	GO:0007062	sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194]	OMA
NV2t013473001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t013473001.1	biological_process	GO:0007202	activation of phospholipase C activity	"The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]	OMA
NV2t013473001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t013473001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t013473001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t013473001.1	biological_process	GO:0031536	positive regulation of exit from mitosis	"Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah]	OMA
NV2t013473001.1	biological_process	GO:0032147	activation of protein kinase activity	"Any process that initiates the activity of an inactive protein kinase." [GOC:mah]	OMA
NV2t013473001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t013473001.1	biological_process	GO:0043433	negative regulation of DNA-binding transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]	OMA
NV2t013473001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013473001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t013473001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t013473001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t013473001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t013473001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t013473001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	OMA
NV2t013473001.1	biological_process	GO:0140374	antiviral innate immune response	"A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [PMID:31006531]	OMA
NV2t013473001.1	biological_process	GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction	"Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade." [GOC:TermGenie]	OMA
NV2t013473001.1	biological_process	GO:1902808	positive regulation of cell cycle G1/S phase transition	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]	OMA
NV2t013473001.1	biological_process	GO:1903725	regulation of phospholipid metabolic process	"Any process that modulates the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]	OMA
NV2t013473001.1	biological_process	GO:1904959	regulation of cytochrome-c oxidase activity	"Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017]	OMA
NV2t013473001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t013473001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013473001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t013473001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013473001.1	cellular_component	GO:0016363	nuclear matrix	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]	OMA
NV2t013473001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t013473001.1	molecular_function	GO:0008022	obsolete protein C-terminus binding	"OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t013473001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t013473001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t013473001.1	molecular_function	GO:0046625	sphingolipid binding	"Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732]	OMA
NV2t013473001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t013473001.1	molecular_function	GO:0047485	obsolete protein N-terminus binding	"OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t013474001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t013474001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t013474001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t013474001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t013474001.1	cellular_component	GO:0120111	neuron projection cytoplasm	"All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha]	OMA
NV2t013474001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013474001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t013474001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t013475001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t013475001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t013475001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t013475001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t013475001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t013476001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t013476001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t013476001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t013477001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013477002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013477004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013477005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477006.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t013477006.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013477006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013477006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477006.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013477006.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t013477007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477009.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477009.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013477010.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477010.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013477011.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t013477011.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013480001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013481001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t013481001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013485001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013485001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t013485001.1	molecular_function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate." [RHEA:14653]	OMA
NV2t013485001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t013485001.1	molecular_function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	"Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+." [RHEA:16957]	PANTHER
NV2t013486001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t013486001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013486001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t013488001.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t013488001.1	biological_process	GO:0045600	positive regulation of fat cell differentiation	"Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]	PANTHER
NV2t013488001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013491001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t013491001.1	biological_process	GO:0044602	protein deadenylylation	"The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid." [GOC:sp, PMID:21734656]	OMA
NV2t013491001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013491001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013491001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t013491001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t013491001.1	molecular_function	GO:0044603	protein adenylylhydrolase activity	"Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins." [PMID:21734656]	OMA
NV2t013491001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t013491001.1	molecular_function	GO:0070733	AMPylase activity	"Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins." [GOC:mah, PMID:19039103, PMID:19362538, PMID:33947243]	OMA
NV2t013495001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013495001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013498001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t013503001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t013503001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t013503001.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	InterPro
NV2t013503001.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	OMA
NV2t013503001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t013503001.1	biological_process	GO:0034097	response to cytokine	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]	OMA
NV2t013503001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013503001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t013503001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t013503001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t013503001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t013504001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013504001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013504001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t013504001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t013505001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t013505001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t013505001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t013505001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t013505001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t013505001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t013505001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	OMA
NV2t013505001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t013505001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t013505001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t013505001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t013505001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t013505001.1	molecular_function	GO:0005113	patched binding	"Binding to a patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473]	OMA
NV2t013505001.1	molecular_function	GO:0005119	smoothened binding	"Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473]	OMA
NV2t013505001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013506001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013506001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t013506001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t013506001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t013506001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t013506001.1	biological_process	GO:0071241	cellular response to inorganic substance	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah]	OMA
NV2t013506001.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t013506001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013506001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013506001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t013506001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013506001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t013506001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t013507001.1	biological_process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	OMA
NV2t013507001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t013507001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t013507001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	OMA
NV2t013507001.1	biological_process	GO:0031990	mRNA export from nucleus in response to heat stress	"The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw]	OMA
NV2t013507001.1	biological_process	GO:0034402	obsolete recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex	"OBSOLETE. The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044]	PANTHER
NV2t013507001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t013507001.1	biological_process	GO:0045948	positive regulation of translational initiation	"Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t013507001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t013507001.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	OMA
NV2t013507001.1	cellular_component	GO:0030880	RNA polymerase complex	"Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah]	InterPro
NV2t013507001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t013507001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t013508001.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013508001.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t013508001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t013508001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013508002.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013508002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013508003.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013508003.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013509001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013509001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013510001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t013511001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t013511001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t013511001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t013511001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t013511001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t013511001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t013511001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t013511001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t013511001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013511001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t013511001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t013511001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t013515001.1	cellular_component	GO:0005684	U2-type spliceosomal complex	"Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900]	PANTHER
NV2t013518001.1	biological_process	GO:0038007	netrin-activated signaling pathway	"The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]	OMA
NV2t013518001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t013520001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013521001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t013521001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013522001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013524001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013525001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t013525001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t013528001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013528001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013528001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013528002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013528003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013530001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013530001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t013530001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t013530001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t013530001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013531001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t013531001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t013531001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	OMA
NV2t013531001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t013531001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t013531001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t013531001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t013531001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t013531001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t013531001.1	biological_process	GO:0051402	neuron apoptotic process	"Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis]	OMA
NV2t013531001.1	biological_process	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t013531001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013531001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013531001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t013531001.1	molecular_function	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	"Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12]	OMA
NV2t013531001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t013531001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t013531001.1	molecular_function	GO:0016769	transferase activity, transferring nitrogenous groups	"Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t013531001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t013531001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t013531001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t013532001.1	biological_process	GO:0006865	amino acid transport	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t013532001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013532001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013532001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013532001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013532002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013532002.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013532003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013532003.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013532004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013532004.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013533001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013533001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t013533001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t013533001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t013533001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013535001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013535001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t013535001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013535001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t013536001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013536001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013536002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013536002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013536002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013536003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013536003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013536003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013536004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013536004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013536004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013536005.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013536005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013536005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013536006.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013536006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013536006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013536007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013536007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013536008.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013536008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013537001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t013537001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	PANTHER
NV2t013537002.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t013537002.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	PANTHER
NV2t013537002.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t013537002.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t013537002.1	biological_process	GO:0061615	glycolytic process through fructose-6-phosphate	"The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479]	OMA
NV2t013537002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013537002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t013537002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t013537002.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t013537003.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t013537003.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	PANTHER
NV2t013538001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t013538001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013538001.1	cellular_component	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	OMA
NV2t013538001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013538001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t013538001.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	OMA
NV2t013538001.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	PANTHER
NV2t013538002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013538002.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	PANTHER
NV2t013538003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013538003.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	PANTHER
NV2t013539001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013539001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013539001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013541001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t013541001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t013541001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t013541001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013541001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013541002.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t013541002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013543001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013543001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013543001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013543001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t013546001.1	biological_process	GO:0001510	RNA methylation	"Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd, PMID:21823225]	OMA
NV2t013546001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t013546001.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	PANTHER
NV2t013546001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t013546001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t013546001.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	InterPro
NV2t013546001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t013546001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t013547001.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	PANTHER
NV2t013547001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013548001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t013548001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013549001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t013549001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t013549001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t013549001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013550001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t013550001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013551001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013551001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013551001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013551002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013551002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013551002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013551002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013551002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013551002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013554001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t013554001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013554002.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t013554002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013554003.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t013554003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013557001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013557002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013557003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013558001.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	PANTHER
NV2t013558002.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	PANTHER
NV2t013560001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t013562001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013562001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013562002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013562002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013562003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013562003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013562004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013562004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013562005.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t013562005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562007.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562008.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013562008.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013562009.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013562009.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562009.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013562010.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013562010.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562010.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013562011.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013562011.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013562011.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013563001.1	biological_process	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]	OMA
NV2t013563001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t013563001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t013563001.1	molecular_function	GO:0050072	obsolete m7G(5')pppN diphosphatase activity	"OBSOLETE. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [GOC:curators]	PANTHER
NV2t013563002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t013563002.1	molecular_function	GO:0050072	obsolete m7G(5')pppN diphosphatase activity	"OBSOLETE. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [GOC:curators]	PANTHER
NV2t013564001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013564001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t013564001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013564001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013564001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013565001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t013565001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t013565001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013566001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t013567001.1	biological_process	GO:0000245	spliceosomal complex assembly	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]	OMA
NV2t013567001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t013567001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013567001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t013567001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t013567001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013567001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013568001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013568001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013569001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013570001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013570001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013570001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t013570001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013570001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013571001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013571001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t013571001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t013571001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013571001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013571001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t013571002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013571002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013571003.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013571003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013571004.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013571004.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013571005.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013571005.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013571006.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013571006.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013575001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013575001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t013576001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t013576001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013576001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t013576001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t013576001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t013576001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t013576002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013577001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013577001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013577001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013578001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013578001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013578001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t013578001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013578001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013582001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	OMA
NV2t013582001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013582001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t013582001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	OMA
NV2t013584001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013584001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t013584001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	InterPro
NV2t013584001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t013584001.1	molecular_function	GO:0008422	beta-glucosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21, PMID:12594539]	PANTHER
NV2t013589001.1	biological_process	GO:0007507	heart development	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]	OMA
NV2t013589001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013589001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013589001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t013589001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t013589001.1	molecular_function	GO:0044548	S100 protein binding	"Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]	InterPro
NV2t013590001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013590001.1	biological_process	GO:0006013	mannose metabolic process	"The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]	InterPro
NV2t013590001.1	biological_process	GO:0006491	N-glycan processing	"The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]	OMA
NV2t013590001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	OMA
NV2t013590001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	PANTHER
NV2t013590001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t013590001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t013590001.1	molecular_function	GO:0004559	alpha-mannosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]	OMA
NV2t013590001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t013590001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t013590002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013590002.1	biological_process	GO:0006013	mannose metabolic process	"The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732]	InterPro
NV2t013590002.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	PANTHER
NV2t013591001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t013591001.1	biological_process	GO:0006783	heme biosynthetic process	"The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607]	InterPro
NV2t013591001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t013591001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t013591001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t013591001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t013591001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t013591001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t013591001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t013591001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t013591001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t013591001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t013591001.1	molecular_function	GO:0004325	ferrochelatase activity	"Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX." [RHEA:22584]	OMA
NV2t013591001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t013594001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013594001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t013594001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	InterPro
NV2t013594001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t013594001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013594001.1	molecular_function	GO:0008422	beta-glucosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21, PMID:12594539]	PANTHER
NV2t013597001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013597001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013597001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013597001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013597001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013599001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t013599001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013599001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013599001.1	molecular_function	GO:0008417	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t013599001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t013600001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t013600001.1	biological_process	GO:0036065	fucosylation	"The covalent attachment of a fucosyl group to an acceptor molecule." [GOC:sart, PMID:19948734]	OMA
NV2t013600001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013600001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013600001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	OMA
NV2t013600001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t013602001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013602001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t013602001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013605001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013607001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t013607001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t013607001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013608001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t013608001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t013608001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t013608001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013608001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013608001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013609001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t013609001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t013609001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t013609001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013609001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013609001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013610001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t013610001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t013610001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t013610001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013610001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013610001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013611001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t013611001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t013611001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013612001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013612001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t013614001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013614001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t013614001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013618001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	PANTHER
NV2t013618001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	InterPro
NV2t013620001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t013620001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	OMA
NV2t013620001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t013620001.1	biological_process	GO:0071951	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	"The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet)." [GOC:jsg, PMID:5337045]	PANTHER
NV2t013620001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013620001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013620001.1	molecular_function	GO:0004479	methionyl-tRNA formyltransferase activity	"Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9]	InterPro
NV2t013620001.1	molecular_function	GO:0016742	hydroxymethyl-, formyl- and related transferase activity	"Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2.-, GOC:mah]	OMA
NV2t013620001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t013627001.1	biological_process	GO:0031293	membrane protein intracellular domain proteolysis	"The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018]	OMA
NV2t013627001.1	biological_process	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	OMA
NV2t013627001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t013627001.1	cellular_component	GO:0030660	Golgi-associated vesicle membrane	"The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]	OMA
NV2t013627001.1	cellular_component	GO:0071556	obsolete integral component of lumenal side of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t013627001.1	cellular_component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	"The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]	OMA
NV2t013627001.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013627001.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t013629001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t013629001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	InterPro
NV2t013629001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	OMA
NV2t013629001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t013629001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013630001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013630001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013630001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t013630001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t013630001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013633001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013633001.1	cellular_component	GO:0044666	MLL3/4 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t013634001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013634001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013634001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t013634001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t013634001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013635001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013636001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013637001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013641001.1	biological_process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t013641001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013641001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013641001.1	molecular_function	GO:0004952	dopamine neurotransmitter receptor activity	"Combining with the neurotransmitter dopamine to initiate a change in cell activity." [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983]	OMA
NV2t013641001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t013641002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013641002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t013642001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	InterPro
NV2t013642001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	OMA
NV2t013642001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013642001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013642001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t013642001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t013642001.1	cellular_component	GO:1905368	peptidase complex	"A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]	OMA
NV2t013642001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013643001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t013643001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013645001.1	biological_process	GO:0042795	snRNA transcription by RNA polymerase II	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]	OMA
NV2t013645001.1	biological_process	GO:0042796	snRNA transcription by RNA polymerase III	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	OMA
NV2t013645001.1	biological_process	GO:0042796	snRNA transcription by RNA polymerase III	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t013645001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013645001.1	cellular_component	GO:0019185	snRNA-activating protein complex	"A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788]	OMA
NV2t013645001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t013645001.1	molecular_function	GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	"Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]	OMA
NV2t013645002.1	biological_process	GO:0042796	snRNA transcription by RNA polymerase III	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t013645003.1	biological_process	GO:0042796	snRNA transcription by RNA polymerase III	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t013647001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013647001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t013647001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t013648001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t013648001.1	molecular_function	GO:0008430	selenium binding	"Binding to a selenium (Se) ion." [GOC:ai]	InterPro
NV2t013648001.1	molecular_function	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]	OMA
NV2t013650001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013650002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013656001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013656001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013656001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	PANTHER
NV2t013656001.1	molecular_function	GO:0015267	channel activity	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013656002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013656002.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	PANTHER
NV2t013657001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013657001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013658001.1	biological_process	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	OMA
NV2t013658001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013658001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t013658001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t013658001.1	biological_process	GO:0010631	epithelial cell migration	"The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t013658001.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t013658001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t013658001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t013658001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t013658001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013658001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t013658001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013658001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t013658001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t013658001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t013658001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013658001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t013658001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013659001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	InterPro
NV2t013659001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	OMA
NV2t013659001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t013659002.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	InterPro
NV2t013659003.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	InterPro
NV2t013665001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013666001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t013667001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013667001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013667001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t013667001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t013669001.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	OMA
NV2t013669001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013669001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t013669001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t013669001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013669001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t013669001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	OMA
NV2t013669001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	PANTHER
NV2t013672001.1	biological_process	GO:0006909	phagocytosis	"A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]	OMA
NV2t013672001.1	biological_process	GO:0018126	protein hydroxylation	"The addition of a hydroxy group to a protein amino acid." [GOC:ai]	OMA
NV2t013672001.1	biological_process	GO:0018205	peptidyl-lysine modification	"The modification of peptidyl-lysine." [GOC:go_curators]	OMA
NV2t013672001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t013672001.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t013672001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t013672001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t013672001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t013672001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t013672001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t013672001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013672001.1	molecular_function	GO:0003727	single-stranded RNA binding	"Binding to single-stranded RNA." [GOC:jl]	OMA
NV2t013672001.1	molecular_function	GO:0033749	histone H4R3 demethylase activity	"Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17947579]	OMA
NV2t013672001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t013672001.1	molecular_function	GO:0106140	P-TEFb complex binding	"Binding to a P-TEFb complex." [GOC:pga, PMID:18391197]	OMA
NV2t013672001.1	molecular_function	GO:0106140	P-TEFb complex binding	"Binding to a P-TEFb complex." [GOC:pga, PMID:18391197]	PANTHER
NV2t013673001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013673001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t013673001.1	biological_process	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	OMA
NV2t013673001.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	PANTHER
NV2t013673001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t013673001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t013673001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t013673001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013673001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013674001.1	biological_process	GO:0018293	protein-FAD linkage	"The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai]	InterPro
NV2t013674001.1	biological_process	GO:0034553	mitochondrial respiratory chain complex II assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]	PANTHER
NV2t013674001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t013674001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013674002.1	biological_process	GO:0018293	protein-FAD linkage	"The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai]	InterPro
NV2t013674002.1	biological_process	GO:0034553	mitochondrial respiratory chain complex II assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]	PANTHER
NV2t013675001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t013675001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013675002.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t013675002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013675003.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t013675003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013675004.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	InterPro
NV2t013677001.1	biological_process	GO:0000054	ribosomal subunit export from nucleus	"The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t013677001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t013677001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013677001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t013677001.1	cellular_component	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	OMA
NV2t013677001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013677001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013677001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013678001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t013678002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t013679001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t013679001.1	biological_process	GO:0036158	outer dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t013679001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t013685001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013685001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013686001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	InterPro
NV2t013687001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t013687001.1	molecular_function	GO:0016835	carbon-oxygen lyase activity	"Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]	OMA
NV2t013687001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013687001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t013687002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013689001.1	biological_process	GO:1990966	ATP generation from poly-ADP-D-ribose	"The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming." [PMID:27257257]	PANTHER
NV2t013690001.1	biological_process	GO:1990966	ATP generation from poly-ADP-D-ribose	"The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming." [PMID:27257257]	PANTHER
NV2t013692001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t013692001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013692001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t013693001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t013693001.1	biological_process	GO:0006282	regulation of DNA repair	"Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]	InterPro
NV2t013693001.1	biological_process	GO:0006282	regulation of DNA repair	"Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]	OMA
NV2t013693001.1	biological_process	GO:1990966	ATP generation from poly-ADP-D-ribose	"The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming." [PMID:27257257]	PANTHER
NV2t013693001.1	molecular_function	GO:0004649	poly(ADP-ribose) glycohydrolase activity	"Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]	OMA
NV2t013694001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t013694001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t013694001.1	biological_process	GO:0016114	terpenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]	OMA
NV2t013694001.1	biological_process	GO:0045337	farnesyl diphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl]	PANTHER
NV2t013694001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013694001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t013694001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t013694001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t013695001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013695001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t013695001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	PANTHER
NV2t013696001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t013696001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t013696001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t013696001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t013696001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t013696001.1	biological_process	GO:0098876	vesicle-mediated transport to the plasma membrane	"The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos]	OMA
NV2t013696001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t013696001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013696001.1	cellular_component	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	OMA
NV2t013696001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013696001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013696001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013697001.1	cellular_component	GO:0043527	tRNA methyltransferase complex	"A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972]	PANTHER
NV2t013697001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013697002.1	cellular_component	GO:0043527	tRNA methyltransferase complex	"A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972]	PANTHER
NV2t013697002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013697003.1	cellular_component	GO:0043527	tRNA methyltransferase complex	"A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972]	PANTHER
NV2t013697003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013697004.1	cellular_component	GO:0043527	tRNA methyltransferase complex	"A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972]	PANTHER
NV2t013697004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013697005.1	biological_process	GO:0001510	RNA methylation	"Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd, PMID:21823225]	OMA
NV2t013697005.1	biological_process	GO:0036265	RNA (guanine-N7)-methylation	"The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule." [GOC:BHF, GOC:rl]	InterPro
NV2t013697005.1	cellular_component	GO:0043527	tRNA methyltransferase complex	"A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972]	PANTHER
NV2t013697005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013698001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	OMA
NV2t013698001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	OMA
NV2t013698001.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	OMA
NV2t013698001.1	biological_process	GO:0075522	IRES-dependent viral translational initiation	"Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation." [GOC:bf, GOC:jl, PMID:19632368, VZ:867]	OMA
NV2t013698001.1	biological_process	GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	OMA
NV2t013698001.1	biological_process	GO:2000767	positive regulation of cytoplasmic translation	"Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	OMA
NV2t013698001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013698001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t013698001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013698001.1	molecular_function	GO:0035613	RNA stem-loop binding	"Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]	OMA
NV2t013699001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013699001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013699001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013701001.1	biological_process	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	OMA
NV2t013701001.1	biological_process	GO:0030327	prenylated protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah]	PANTHER
NV2t013701001.1	biological_process	GO:0030328	prenylcysteine catabolic process	"The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]	InterPro
NV2t013701001.1	biological_process	GO:0042219	cellular modified amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t013701001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t013701001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t013701001.1	cellular_component	GO:0032994	protein-lipid complex	"A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." [GOC:mah]	OMA
NV2t013701001.1	molecular_function	GO:0001735	prenylcysteine oxidase activity	"Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd, RHEA:53892]	InterPro
NV2t013701001.1	molecular_function	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]	OMA
NV2t013701001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t013702001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t013702001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013702001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t013702001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t013702001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t013703001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013703002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013703003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013704001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t013704001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013704001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013704002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013707001.1	biological_process	GO:0030327	prenylated protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah]	PANTHER
NV2t013707001.1	biological_process	GO:0030328	prenylcysteine catabolic process	"The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]	InterPro
NV2t013707001.1	molecular_function	GO:0001735	prenylcysteine oxidase activity	"Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd, RHEA:53892]	InterPro
NV2t013708001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t013708001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013708001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013710001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t013712001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013712001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013712001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t013712001.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t013712001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t013712001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013712001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013712001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013712001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t013712001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t013712001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013714001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t013714001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t013715001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t013715001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013715001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013719001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t013719001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t013719001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t013719001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t013721001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013721001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013721001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t013721001.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t013721001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t013721001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013721001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013721001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013721001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t013721001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t013721001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013722001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t013722001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t013722001.1	biological_process	GO:0060627	regulation of vesicle-mediated transport	"Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]	OMA
NV2t013722001.1	biological_process	GO:2000156	regulation of retrograde vesicle-mediated transport, Golgi to ER	"Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER." [GOC:mah]	PANTHER
NV2t013722001.1	cellular_component	GO:0000138	Golgi trans cisterna	"The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]	OMA
NV2t013722001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t013722001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t013723001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t013723001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013724001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t013724001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013724002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t013724002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t013724002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013724002.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t013724002.1	molecular_function	GO:0015276	ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013725001.1	biological_process	GO:0006552	L-leucine catabolic process	"The chemical reactions and pathways resulting in the breakdown of L-leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]	OMA
NV2t013725001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t013725001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t013725001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t013725001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	OMA
NV2t013725001.1	molecular_function	GO:0008470	isovaleryl-CoA dehydrogenase activity	"Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]." [PMID:25450250, PMID:7640268, RHEA:12276]	PANTHER
NV2t013725001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t013725001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t013725001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t013725001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t013726001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013726001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013726001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013726001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t013726001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013729001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	InterPro
NV2t013729001.1	biological_process	GO:0042797	tRNA transcription by RNA polymerase III	"The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t013729002.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	InterPro
NV2t013729002.1	biological_process	GO:0042797	tRNA transcription by RNA polymerase III	"The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t013730001.1	cellular_component	GO:0071007	U2-type catalytic step 2 spliceosome	"A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013730001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013730001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013730001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t013730001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t013730001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t013731001.1	biological_process	GO:0036444	calcium import into the mitochondrion	"A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix." [GOC:vw]	OMA
NV2t013731001.1	biological_process	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t013731001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t013731001.1	biological_process	GO:0051259	protein complex oligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929]	OMA
NV2t013731001.1	biological_process	GO:0051560	mitochondrial calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]	OMA
NV2t013731001.1	cellular_component	GO:0034704	calcium channel complex	"An ion channel complex through which calcium ions pass." [GOC:mah]	OMA
NV2t013731001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t013731001.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	PANTHER
NV2t013731001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t013731001.1	molecular_function	GO:0015291	secondary active transmembrane transporter activity	"Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]	OMA
NV2t013731001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t013731002.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	PANTHER
NV2t013732001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013732001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013732002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013732002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013732003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013732003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013732004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013732004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013732005.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013732005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013732006.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013732006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013732007.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t013732007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013734001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t013734001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013734001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013734002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013737001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013737002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013737003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013737004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t013738001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013738001.1	biological_process	GO:0006607	NLS-bearing protein import into nucleus	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai]	OMA
NV2t013738001.1	biological_process	GO:0006999	nuclear pore organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]	OMA
NV2t013738001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	InterPro
NV2t013738001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t013738001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t013738001.1	cellular_component	GO:0044615	nuclear pore nuclear basket	"A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t013738001.1	cellular_component	GO:0044615	nuclear pore nuclear basket	"A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t013738001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013738001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t013738001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t013738001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t013739001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t013739001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t013739001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t013739001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t013739001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t013739001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t013739001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t013739001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t013739001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t013740001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t013740001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013741001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t013741001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t013741001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	InterPro
NV2t013741001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t013741001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t013741001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t013741001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t013742001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013742001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013742001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013742002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013742002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t013742002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013742002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013742002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013742002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013743001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013743001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013743001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013743002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013743002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013743002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013744001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013744001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013745001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013745001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t013745001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013745001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013745002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013745002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t013745002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013745002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013745003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013745003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t013745003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013745003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013745004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013745004.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t013745004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013745004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013745005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013745005.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t013745005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013745005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013746001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013746001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t013746001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013746001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013746001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013747001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013747001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t013747001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013747001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013747001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013747001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013748001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013748001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t013749001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013749001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t013749001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013749001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013750001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013750001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013750001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013750002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013750002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013750002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013750003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013750003.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t013750003.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013750003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013750003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013750003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013750004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013750004.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013750004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013750005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013750005.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013750005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013751002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013751002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013751002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013751002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013751003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013751004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013751005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013751006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013754001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t013754001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	OMA
NV2t013754001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t013754001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t013754001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t013754001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t013757001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t013758001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t013758001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t013758001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t013758001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013760001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t013760001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t013760001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t013768001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013768002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013768003.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013768004.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013768005.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013770001.1	biological_process	GO:0030473	nuclear migration along microtubule	"The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators]	OMA
NV2t013770001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t013770001.1	molecular_function	GO:0005521	lamin binding	"Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732]	OMA
NV2t013770001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t013770001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t013770002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t013770003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t013773001.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t013773001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t013773001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013773001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013777001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013777001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013780001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013780001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t013780001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013780001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013780001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t013780001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t013780001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t013781001.1	biological_process	GO:0003013	circulatory system process	"A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]	OMA
NV2t013781001.1	biological_process	GO:0007417	central nervous system development	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]	OMA
NV2t013781001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t013781001.1	biological_process	GO:0032868	response to insulin	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t013781001.1	biological_process	GO:0045494	photoreceptor cell maintenance	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]	OMA
NV2t013781001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013781001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t013781001.1	biological_process	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	OMA
NV2t013781001.1	biological_process	GO:0098739	import across plasma membrane	"The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t013781001.1	biological_process	GO:1905039	carboxylic acid transmembrane transport	"The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]	OMA
NV2t013781001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t013781001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013781001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t013781001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t013781001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t013781001.1	cellular_component	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	OMA
NV2t013781001.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t013781001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t013781001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013781001.1	molecular_function	GO:0008514	organic anion transmembrane transporter activity	"Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t013781001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013781001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t013781001.1	molecular_function	GO:0043621	obsolete protein self-association	"OBSOLETE. Binding to a domain within the same polypeptide." [GOC:jl]	OMA
NV2t013781001.1	molecular_function	GO:0090482	vitamin transmembrane transporter activity	"Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb]	OMA
NV2t013781002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013781002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013781002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013781003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013781003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013781003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013781004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013781004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013781004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013781005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013781005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013781005.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013784001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013784001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013785001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t013785001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013785001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t013785002.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t013786001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013786002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013789001.1	biological_process	GO:0006836	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	OMA
NV2t013789001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t013789001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t013789001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	InterPro
NV2t013789001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t013790001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013790001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013791001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	InterPro
NV2t013791001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013791002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	InterPro
NV2t013791002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013791003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013792001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013792001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013792002.1	biological_process	GO:0030719	P granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]	OMA
NV2t013792002.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	OMA
NV2t013792002.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t013792002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t013792002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t013792002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t013793001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t013793001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013793001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t013794001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t013795001.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t013795001.1	biological_process	GO:0042572	retinol metabolic process	"The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]	OMA
NV2t013795001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t013795001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t013795001.1	molecular_function	GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	"Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [RHEA:21284]	OMA
NV2t013795001.1	molecular_function	GO:0016229	steroid dehydrogenase activity	"Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]	OMA
NV2t013795001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013796001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t013796001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013797001.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t013797001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t013797001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t013797001.1	molecular_function	GO:0016229	steroid dehydrogenase activity	"Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]	OMA
NV2t013797001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013798001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013798001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013798001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013798002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013798003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013799001.1	biological_process	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544]	OMA
NV2t013799001.1	biological_process	GO:0033962	P-body assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]	PANTHER
NV2t013799001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t013801001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t013802001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013803001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013803001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013804001.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t013804001.1	biological_process	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	OMA
NV2t013804001.1	biological_process	GO:0007369	gastrulation	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]	OMA
NV2t013804001.1	biological_process	GO:0009226	nucleotide-sugar biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]	OMA
NV2t013804001.1	biological_process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]	OMA
NV2t013804001.1	biological_process	GO:0030206	chondroitin sulfate biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]	OMA
NV2t013804001.1	biological_process	GO:0046394	carboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t013804001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t013804001.1	biological_process	GO:0051259	protein complex oligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929]	OMA
NV2t013804001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013804001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013804001.1	molecular_function	GO:0003979	UDP-glucose 6-dehydrogenase activity	"Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596]	InterPro
NV2t013804001.1	molecular_function	GO:0003979	UDP-glucose 6-dehydrogenase activity	"Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596]	OMA
NV2t013804001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t013804001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t013804001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t013804001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t013804002.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t013804002.1	molecular_function	GO:0003979	UDP-glucose 6-dehydrogenase activity	"Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596]	InterPro
NV2t013804002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t013804002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t013804003.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t013804003.1	molecular_function	GO:0003979	UDP-glucose 6-dehydrogenase activity	"Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596]	InterPro
NV2t013804003.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t013804003.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t013804004.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t013804004.1	molecular_function	GO:0003979	UDP-glucose 6-dehydrogenase activity	"Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596]	InterPro
NV2t013804004.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t013804004.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t013806001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t013807001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t013807001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t013808001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t013808001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013808002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t013808002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013809001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t013809001.1	molecular_function	GO:0071885	N-terminal protein N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [PMID:20481588]	PANTHER
NV2t013809002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t013809002.1	molecular_function	GO:0071885	N-terminal protein N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [PMID:20481588]	PANTHER
NV2t013811001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t013811001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t013811001.1	biological_process	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t013811001.1	biological_process	GO:0051094	positive regulation of developmental process	"Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t013811001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013811001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013811001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t013811001.1	molecular_function	GO:0003925	G protein activity	"A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]	OMA
NV2t013811001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t013811001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t013811001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t013811001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t013813001.1	biological_process	GO:0006549	isoleucine metabolic process	"The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	OMA
NV2t013813001.1	biological_process	GO:0006573	valine metabolic process	"The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai]	OMA
NV2t013813001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t013813001.1	biological_process	GO:0019395	fatty acid oxidation	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t013813001.1	biological_process	GO:1901607	alpha-amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t013813001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013813001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013813001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t013813001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t013813001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t013813001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t013813001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t013813001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t013813001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t013813001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t013813001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t013813002.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t013813002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t013815001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t013815001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013815001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013815001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t013815001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t013815001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	OMA
NV2t013815002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t013816001.1	biological_process	GO:0006044	N-acetylglucosamine metabolic process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]	OMA
NV2t013816001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t013816001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013816001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013816001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t013816001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t013816001.1	molecular_function	GO:0140103	catalytic activity, acting on a glycoprotein	"Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t013817001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t013817001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t013817001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013817001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t013817001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t013817001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t013817001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013819001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013825001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t013825001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t013825001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t013825001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	OMA
NV2t013825001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t013825001.1	biological_process	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	PANTHER
NV2t013825001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t013825001.1	molecular_function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	"Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]	OMA
NV2t013825001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t013825001.1	molecular_function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]	OMA
NV2t013825001.1	molecular_function	GO:0052745	inositol phosphate phosphatase activity	"Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]	OMA
NV2t013826001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	PANTHER
NV2t013828001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t013828001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t013828001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t013828001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t013828001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t013828001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t013828001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t013828001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t013828001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t013828001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013829001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t013829001.1	biological_process	GO:0032979	protein insertion into mitochondrial inner membrane from matrix	"The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [GOC:vw, PMID:12880202, PMID:15473843]	OMA
NV2t013829001.1	biological_process	GO:0033108	mitochondrial respiratory chain complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]	OMA
NV2t013829001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	PANTHER
NV2t013829001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t013829001.1	molecular_function	GO:0032977	membrane insertase activity	"Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]	OMA
NV2t013829002.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	PANTHER
NV2t013831001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013831001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013832001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013832001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013833001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013833001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013833001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t013833001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t013833002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013834001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013834001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013836001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013836001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013837001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013837001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t013837001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013837001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013837001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013838001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013838001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013838001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013838001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013838001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t013838001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t013839001.1	biological_process	GO:0046545	development of primary female sexual characteristics	"The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai]	OMA
NV2t013839001.1	biological_process	GO:0046546	development of primary male sexual characteristics	"The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai]	OMA
NV2t013839001.1	biological_process	GO:1905516	positive regulation of fertilization	"Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576]	OMA
NV2t013839001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013839001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t013840001.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	OMA
NV2t013840001.1	biological_process	GO:0015803	branched-chain amino acid transport	"The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf]	OMA
NV2t013840001.1	biological_process	GO:0015803	branched-chain amino acid transport	"The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf]	PANTHER
NV2t013840001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013840001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t013840001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013843001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t013843001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t013843001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t013843001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t013843001.1	biological_process	GO:0051256	mitotic spindle midzone assembly	"The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120]	OMA
NV2t013843001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013843001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t013843001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t013843001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t013843001.1	cellular_component	GO:0045171	intercellular bridge	"A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." [PMID:9635420]	OMA
NV2t013843001.1	cellular_component	GO:0097149	centralspindlin complex	"A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals)." [GOC:ans, PMID:11782313, PMID:16236794]	OMA
NV2t013843001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t013843001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013843001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t013843001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t013843001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t013843001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t013844001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013844001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t013844001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t013844001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t013844001.1	cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]	OMA
NV2t013844001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t013844001.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t013844001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t013844001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t013844001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013845001.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845001.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t013845001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t013845001.1	biological_process	GO:0046653	tetrahydrofolate metabolic process	"The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	OMA
NV2t013845001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013845001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t013845001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t013845001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013845002.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013845003.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845003.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013845004.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845004.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013845005.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845005.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013845006.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845006.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013845007.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845007.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013845008.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845008.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013845009.1	biological_process	GO:0006555	methionine metabolic process	"The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013845009.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t013846001.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	PANTHER
NV2t013846001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013846001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013846002.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	PANTHER
NV2t013846002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013847001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t013848001.1	biological_process	GO:0006405	RNA export from nucleus	"The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t013848001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t013848001.1	cellular_component	GO:0044611	nuclear pore inner ring	"A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t013848001.1	cellular_component	GO:0044611	nuclear pore inner ring	"A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t013848001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t013848001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t013848002.1	cellular_component	GO:0044611	nuclear pore inner ring	"A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t013848002.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t013848003.1	cellular_component	GO:0044611	nuclear pore inner ring	"A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t013848003.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t013850001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013850001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013850001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t013850001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013850001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013850001.1	molecular_function	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis]	PANTHER
NV2t013851001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013851001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t013851001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013851001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t013851002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013851002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t013851002.1	biological_process	GO:0009953	dorsal/ventral pattern formation	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t013851002.1	biological_process	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	OMA
NV2t013851002.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t013851002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013851002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013851002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t013851002.1	molecular_function	GO:0005024	transforming growth factor beta receptor activity	"Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]	OMA
NV2t013851002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t013851002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013851002.1	molecular_function	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	OMA
NV2t013856001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013856001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013856001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013856001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	PANTHER
NV2t013857001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t013857001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t013858001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	InterPro
NV2t013858001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t013858001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013858001.1	cellular_component	GO:0031501	mannosyltransferase complex	"A complex that posseses mannosyltransferase activity." [GOC:mah]	OMA
NV2t013858001.1	cellular_component	GO:0031501	mannosyltransferase complex	"A complex that posseses mannosyltransferase activity." [GOC:mah]	PANTHER
NV2t013858001.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	OMA
NV2t013859001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t013859001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t013859001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013859001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t013861001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t013861001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t013861001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	PANTHER
NV2t013861001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t013861001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	OMA
NV2t013861002.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	PANTHER
NV2t013861002.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t013862001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t013862001.1	biological_process	GO:0022414	reproductive process	"A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]	OMA
NV2t013862001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t013862001.1	biological_process	GO:0048666	neuron development	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]	OMA
NV2t013862001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	OMA
NV2t013862001.1	biological_process	GO:1901890	positive regulation of cell junction assembly	"Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t013862001.1	biological_process	GO:1904491	protein localization to ciliary transition zone	"A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230]	OMA
NV2t013862001.1	biological_process	GO:1904491	protein localization to ciliary transition zone	"A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230]	PANTHER
NV2t013862001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013862001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t013862001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t013862001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t013862001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t013862001.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	OMA
NV2t013862001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t013864001.1	biological_process	GO:0051496	positive regulation of stress fiber assembly	"Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	PANTHER
NV2t013864001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013864001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013864002.1	biological_process	GO:0051496	positive regulation of stress fiber assembly	"Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	PANTHER
NV2t013864002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013864002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013864003.1	biological_process	GO:0051496	positive regulation of stress fiber assembly	"Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	PANTHER
NV2t013864003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013864003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013866001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t013866001.1	molecular_function	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	InterPro
NV2t013866001.1	molecular_function	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	OMA
NV2t013866001.1	molecular_function	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	PANTHER
NV2t013867001.1	biological_process	GO:0006903	vesicle targeting	"The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]	OMA
NV2t013867001.1	biological_process	GO:0034454	microtubule anchoring at centrosome	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]	OMA
NV2t013867001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t013867001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t013867001.1	biological_process	GO:0097712	vesicle targeting, trans-Golgi to periciliary membrane compartment	"The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645, Reactome:R-HSA-5620920.1]	PANTHER
NV2t013867001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t013867001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t013867001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t013867001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t013869001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013869001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013871001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t013871001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013871001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013872001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	PANTHER
NV2t013872001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t013872001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t013872001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013872002.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	PANTHER
NV2t013873001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013873001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013873001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013874001.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	InterPro
NV2t013874001.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	OMA
NV2t013874001.1	biological_process	GO:0006739	NADP metabolic process	"The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	PANTHER
NV2t013874001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t013874001.1	molecular_function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	"Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH." [RHEA:19629]	OMA
NV2t013874001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t013874001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t013874002.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	InterPro
NV2t013874002.1	biological_process	GO:0006739	NADP metabolic process	"The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	PANTHER
NV2t013874002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t013876001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013876001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013877001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013877001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013878001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013878001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t013878002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013878002.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t013878003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013878003.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t013878004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013878004.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t013878005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013878005.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t013878006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013878006.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t013880001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013880001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t013880001.1	molecular_function	GO:0030267	glyoxylate reductase (NADPH) activity	"Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [RHEA:10992]	PANTHER
NV2t013880001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t013880001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t013881001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013881001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t013883001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t013883004.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t013885001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013885001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t013885001.1	biological_process	GO:0032922	circadian regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]	OMA
NV2t013885001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t013885001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013885001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t013885001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t013885001.1	molecular_function	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	PANTHER
NV2t013887001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t013890001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t013890002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t013890003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t013890004.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t013890005.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t013891001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013891001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013891001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013891001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013891002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013891002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013891002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013891002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013891003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013891003.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013891003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013891004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t013891004.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t013891004.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t013892001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t013892001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t013892001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t013892001.1	molecular_function	GO:0004558	alpha-1,4-glucosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20]	PANTHER
NV2t013892001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t013892001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t013893001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t013893001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013893002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013893002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013893002.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t013893002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013893002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013893003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013893003.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t013893003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013893004.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t013893004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013894001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013894001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013894001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013894002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013894002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013894003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013894003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013894003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013894003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013894003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013894003.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013894004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013894004.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t013897001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t013897001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t013897001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t013897001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t013897001.1	molecular_function	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN]	PANTHER
NV2t013898001.1	biological_process	GO:0006936	muscle contraction	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]	OMA
NV2t013898001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t013898001.1	biological_process	GO:0030239	myofibril assembly	"Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]	OMA
NV2t013898001.1	biological_process	GO:0051693	actin filament capping	"The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	OMA
NV2t013898001.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013898001.1	cellular_component	GO:0005865	striated muscle thin filament	"Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194]	OMA
NV2t013898001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t013898001.1	molecular_function	GO:0005523	tropomyosin binding	"Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194]	OMA
NV2t013898001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t013898002.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013898003.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013898003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013898004.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013898005.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013898006.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013898006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013898007.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013898007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013898008.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013899001.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013899001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013899002.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013899002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013899003.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013899003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013899004.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013899004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013899005.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013899005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013899006.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013899006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013899007.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013899007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013899008.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013899008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013900001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013900001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013900001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t013901001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013901001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013901001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013902001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013902001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013902001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013903001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	PANTHER
NV2t013905001.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013905001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013906001.1	biological_process	GO:0051694	pointed-end actin filament capping	"The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	InterPro
NV2t013907001.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013907001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013907002.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013907002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013907003.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013907003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013907004.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013907004.1	cellular_component	GO:0043296	apical junction complex	"A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]	OMA
NV2t013907004.1	cellular_component	GO:0070160	tight junction	"A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181]	OMA
NV2t013907004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013907005.1	biological_process	GO:0150105	protein localization to cell-cell junction	"A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435]	PANTHER
NV2t013907005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013908001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013908001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t013909001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013909001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013910001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013910001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013910002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013910002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013910002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t013910003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013910003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t013911001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013911001.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	OMA
NV2t013911001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	PANTHER
NV2t013912001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t013912001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013913001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013914001.1	biological_process	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	InterPro
NV2t013914001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t013914001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013916001.1	biological_process	GO:0006693	prostaglandin metabolic process	"The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]	OMA
NV2t013916001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t013916001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t013916001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t013916001.1	molecular_function	GO:0047522	15-oxoprostaglandin 13-oxidase activity	"Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG_REACTION:R04556, KEGG_REACTION:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN]	PANTHER
NV2t013918001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t013918001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013918001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t013918002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t013918002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t013918003.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t013918003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013918003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t013918004.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t013918004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013918004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t013918005.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t013918005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013918005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t013918006.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	PANTHER
NV2t013918007.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	PANTHER
NV2t013921001.1	biological_process	GO:0002098	tRNA wobble uridine modification	"The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]	PANTHER
NV2t013921001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013921001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t013924001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	PANTHER
NV2t013924002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	PANTHER
NV2t013924003.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	PANTHER
NV2t013924004.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	PANTHER
NV2t013925001.1	biological_process	GO:0043933	protein-containing complex organization	"Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah]	OMA
NV2t013925001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t013925001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	PANTHER
NV2t013926001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013926001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013926001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t013926001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t013926001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t013927001.1	biological_process	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t013928001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t013928001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t013928001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t013929001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t013929001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t013929001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t013929001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t013929001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t013929001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t013929001.1	molecular_function	GO:0033980	phosphonopyruvate decarboxylase activity	"Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde." [EC:4.1.1.82, RHEA:20768]	InterPro
NV2t013929001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t013929001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t013929001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t013929001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t013929001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t013929002.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t013929002.1	molecular_function	GO:0033980	phosphonopyruvate decarboxylase activity	"Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde." [EC:4.1.1.82, RHEA:20768]	InterPro
NV2t013930001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t013930001.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t013930001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013930001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013930001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t013930001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t013930001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013930002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013930002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013931001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t013931001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t013931001.1	cellular_component	GO:0000974	Prp19 complex	"A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]	OMA
NV2t013931001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013931001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t013931001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t013931001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t013932001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t013933001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t013933001.1	molecular_function	GO:0033980	phosphonopyruvate decarboxylase activity	"Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde." [EC:4.1.1.82, RHEA:20768]	InterPro
NV2t013934001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t013934001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013936001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t013936001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t013936001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t013937001.1	biological_process	GO:0043542	endothelial cell migration	"The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]	PANTHER
NV2t013937001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013937002.1	biological_process	GO:0043542	endothelial cell migration	"The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]	PANTHER
NV2t013937002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013937003.1	biological_process	GO:0043542	endothelial cell migration	"The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]	PANTHER
NV2t013937003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013937004.1	biological_process	GO:0043542	endothelial cell migration	"The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]	PANTHER
NV2t013937004.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013937005.1	biological_process	GO:0043542	endothelial cell migration	"The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]	PANTHER
NV2t013937005.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013937006.1	biological_process	GO:0043542	endothelial cell migration	"The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]	PANTHER
NV2t013937006.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013938001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013938001.1	cellular_component	GO:0071561	nucleus-vacuole junction	"An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156, PMID:16806880]	PANTHER
NV2t013938001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013938002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t013938002.1	cellular_component	GO:0071561	nucleus-vacuole junction	"An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156, PMID:16806880]	PANTHER
NV2t013938002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013940001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t013940001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t013940001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	OMA
NV2t013940001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t013940001.1	cellular_component	GO:0001669	acrosomal vesicle	"A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]	OMA
NV2t013940001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t013940001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t013940001.1	cellular_component	GO:0097228	sperm principal piece	"The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836]	PANTHER
NV2t013940001.1	molecular_function	GO:0005227	calcium-activated cation channel activity	"Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	OMA
NV2t013940001.1	molecular_function	GO:0005245	voltage-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]	OMA
NV2t013942001.1	molecular_function	GO:0032422	purine-rich negative regulatory element binding	"Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411]	InterPro
NV2t013943001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t013943001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t013943001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013943001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t013943001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t013945001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013945001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t013945002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013945002.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t013945003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013946001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t013946001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t013946001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013946001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t013946001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t013946001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t013946001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t013946002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t013946002.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t013947001.1	molecular_function	GO:0016151	nickel cation binding	"Binding to a nickel (Ni) cation." [GOC:ai]	InterPro
NV2t013949001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t013949001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t013949002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t013950001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t013950001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t013950001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t013950001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t013950001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t013950001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t013950001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013950002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t013950002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013950003.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t013950003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t013950003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013953001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013953001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t013953001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t013955001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013955001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013955001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013955002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013955002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t013955002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t013955002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t013955002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t013955002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013956001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013956001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013956001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t013956001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013956002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013956002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013956002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013956003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013956003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013956003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013956004.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013956004.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013956004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013956005.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t013956005.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t013956005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013959001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013959001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t013959001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013962001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013962001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013962001.1	cellular_component	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	PANTHER
NV2t013962001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013963001.1	biological_process	GO:0003151	outflow tract morphogenesis	"The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]	OMA
NV2t013963001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t013963001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013963001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t013963001.1	biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]	OMA
NV2t013963001.1	biological_process	GO:0007352	zygotic specification of dorsal/ventral axis	"The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf]	OMA
NV2t013963001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t013963001.1	biological_process	GO:0010991	obsolete negative regulation of SMAD protein complex assembly	"OBSOLETE. Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t013963001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t013963001.1	biological_process	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	OMA
NV2t013963001.1	biological_process	GO:0030514	negative regulation of BMP signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]	OMA
NV2t013963001.1	biological_process	GO:0031589	cell-substrate adhesion	"The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]	OMA
NV2t013963001.1	biological_process	GO:0032496	response to lipopolysaccharide	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464]	OMA
NV2t013963001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t013963001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t013963001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t013963001.1	biological_process	GO:0060394	obsolete negative regulation of pathway-restricted SMAD protein phosphorylation	"OBSOLETE. Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t013963001.1	biological_process	GO:0060395	SMAD protein signal transduction	"An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF]	OMA
NV2t013963001.1	cellular_component	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	OMA
NV2t013963001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t013963001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t013963001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013963001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t013963001.1	molecular_function	GO:0034713	type I transforming growth factor beta receptor binding	"Binding to a type I transforming growth factor beta receptor." [GOC:BHF, GOC:mah]	OMA
NV2t013963001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t013963001.1	molecular_function	GO:0070410	co-SMAD binding	"Binding to a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]	OMA
NV2t013963001.1	molecular_function	GO:0070411	I-SMAD binding	"Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]	OMA
NV2t013963001.1	molecular_function	GO:0070697	activin receptor binding	"Binding to an activin receptor." [GOC:BHF, GOC:vk]	OMA
NV2t013963001.1	molecular_function	GO:0140416	transcription regulator inhibitor activity	"A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification." [PMID:10652346]	PANTHER
NV2t013963001.1	molecular_function	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t013964001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013964001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013964001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013966001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013966001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t013966001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t013966001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013966001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t013968001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t013968001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013968002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013968003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013968004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013968005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013969001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t013971001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t013971001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	PANTHER
NV2t013971001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013972001.1	biological_process	GO:0090374	oligopeptide export from mitochondrion	"The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115]	PANTHER
NV2t013972001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013972001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013972001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013972001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t013972001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t013972002.1	biological_process	GO:0090374	oligopeptide export from mitochondrion	"The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115]	PANTHER
NV2t013972002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013972002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t013977001.1	biological_process	GO:0090374	oligopeptide export from mitochondrion	"The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115]	PANTHER
NV2t013977001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013977001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t013977001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t013977002.1	biological_process	GO:0090374	oligopeptide export from mitochondrion	"The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115]	PANTHER
NV2t013977002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013977002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t013979001.1	biological_process	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage	"Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine." [GOC:mah, GOC:tb, PMID:17998288]	PANTHER
NV2t013980001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013980001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t013980001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t013980001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t013980002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013980002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t013980002.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t013980003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013980003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t013980003.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t013980004.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013980004.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t013980004.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t013981001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t013983001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013983001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t013983001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t013983001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t013983001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t013984001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t013984001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	PANTHER
NV2t013985001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t013985001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	InterPro
NV2t013985001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t013985001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t013985001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t013985001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t013985001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t013985001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t013985001.1	cellular_component	GO:0016581	NuRD complex	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]	OMA
NV2t013985001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t013985001.1	molecular_function	GO:0001221	transcription coregulator binding	"Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc]	OMA
NV2t013985001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t013985001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t013985001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t013985001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t013985001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t013985001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	OMA
NV2t013985001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t013985001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t013985001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t013985001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t013985002.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	InterPro
NV2t013985002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t013985002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t013986001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t013986001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t013986001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t013986001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t013986001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t013986001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t013988001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t013988001.1	biological_process	GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t013990001.1	cellular_component	GO:0031417	NatC complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471]	InterPro
NV2t013992001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t013994001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t013994001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t013994001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t013994001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t013996003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t013996003.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t013996003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t013996003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t013999001.1	biological_process	GO:0042421	norepinephrine biosynthetic process	"The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t014000001.1	molecular_function	GO:0004500	dopamine beta-monooxygenase activity	"Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]	InterPro
NV2t014002001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	InterPro
NV2t014002001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t014002001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	PANTHER
NV2t014004001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014005001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t014007001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t014007001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014007002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t014007002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014007003.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t014007003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014010001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t014010001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014015001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t014015001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014016001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t014016001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014016001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014016001.1	molecular_function	GO:0008417	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t014016001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t014017001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t014017001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t014017001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t014017001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t014017001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014017001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014017001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014017001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t014017001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t014017002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t014017002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t014017002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t014018001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t014018001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t014018001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t014018001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t014018001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014018001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t014018001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t014019001.1	biological_process	GO:0010133	proline catabolic process to glutamate	"The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz]	PANTHER
NV2t014019001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014019002.1	biological_process	GO:0010133	proline catabolic process to glutamate	"The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz]	PANTHER
NV2t014019002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014019003.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t014019003.1	biological_process	GO:0006562	proline catabolic process	"The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t014019003.1	biological_process	GO:0010133	proline catabolic process to glutamate	"The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz]	InterPro
NV2t014019003.1	biological_process	GO:0010133	proline catabolic process to glutamate	"The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz]	PANTHER
NV2t014019003.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t014019003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014019003.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t014019003.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t014021001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014021002.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014021003.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014021004.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014021005.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t014021005.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t014021005.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t014021005.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	OMA
NV2t014021005.1	biological_process	GO:0010821	regulation of mitochondrion organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]	OMA
NV2t014021005.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t014021005.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t014021005.1	biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t014021005.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t014021005.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t014021005.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021005.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t014021005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014021005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t014021005.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t014021006.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021006.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014021007.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021007.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014021008.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021008.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014021009.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	PANTHER
NV2t014021009.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014025001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t014025001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t014025001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014030001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014030001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014030001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014030001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t014030001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t014030001.1	molecular_function	GO:0005247	voltage-gated chloride channel activity	"Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014031001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t014031001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t014031001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t014031001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t014031001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t014031001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t014031001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t014031001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014031001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014031001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t014033001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t014033001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014033001.1	biological_process	GO:0038060	nitric oxide-cGMP-mediated signaling	"An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632]	OMA
NV2t014033001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	OMA
NV2t014033001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t014033001.1	cellular_component	GO:0008074	guanylate cyclase complex, soluble	"Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]	OMA
NV2t014033001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t014033001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014033001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t014033002.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t014033002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014033002.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t014033002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014033003.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t014033003.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t014033003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014033004.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t014033004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014033004.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t014033004.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014034001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t014034001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014034001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t014034001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014034002.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t014034002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014034002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t014034002.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t014034002.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t014034002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014034002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t014034003.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t014034003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014034003.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t014034003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014036001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t014037001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014037001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014038001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t014038001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t014039001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014040001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014040001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014040001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t014041001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014041001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014041002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014041002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014041003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014041003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014043001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014043001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t014043001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t014043001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014045001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t014045001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014045001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t014046001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014046001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t014046002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014046002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014046002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t014046003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014046003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014046004.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014046004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014046005.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014046005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014046006.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t014046006.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014046006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014047001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t014047001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014047001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014048001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014048001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014050001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014053001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t014053001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014053001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t014054001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t014054001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014054002.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t014054002.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t014054002.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t014054002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t014054002.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t014054002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014054002.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t014055001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t014055001.1	biological_process	GO:0050806	positive regulation of synaptic transmission	"Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]	OMA
NV2t014055001.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	OMA
NV2t014055001.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014055001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t014055001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014055001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t014055001.1	molecular_function	GO:0001540	amyloid-beta binding	"Binding to an amyloid-beta peptide/protein." [GOC:hjd]	OMA
NV2t014055001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014055001.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	OMA
NV2t014055002.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014055002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014055003.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014055003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014055004.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014055004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014055005.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014055005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014055006.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014055006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014055007.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014055007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014056001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014056001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014056002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014056002.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014057001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t014059001.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014060001.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	PANTHER
NV2t014061001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014061001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014061001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014061001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014062001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t014062001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t014062001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014062001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014062001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t014062001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t014062001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t014062002.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t014063001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t014063001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t014063001.1	biological_process	GO:0045815	transcription initiation-coupled chromatin remodeling	"An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA." [PMID:34414474]	OMA
NV2t014063001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t014063001.1	biological_process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	"Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]	OMA
NV2t014063001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t014063001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014063001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t014063001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t014063001.1	molecular_function	GO:0140849	ATP-dependent H2AZ histone chaperone activity	"A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite." [PMID:21241891, PMID:23580526, PMID:30309918]	InterPro
NV2t014063001.1	molecular_function	GO:0140849	ATP-dependent H2AZ histone chaperone activity	"A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite." [PMID:21241891, PMID:23580526, PMID:30309918]	OMA
NV2t014064001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t014064001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t014064001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014064001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t014067001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t014067001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t014067001.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	OMA
NV2t014067001.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	OMA
NV2t014067001.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t014067001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014067001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t014067001.1	cellular_component	GO:0032432	actin filament bundle	"An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]	OMA
NV2t014067001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t014067001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014067001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014067001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014067001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t014067002.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t014067002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014067002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014067003.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t014067003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014067004.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t014067004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014067004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014067005.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t014067005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014067005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014067006.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t014067006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014067006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014067007.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t014067007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014069001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014070001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t014070001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t014070001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014070001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t014091001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014091001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014092001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014092001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014092001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t014093001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014093001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t014096001.1	biological_process	GO:0019448	L-cysteine catabolic process	"The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [GOC:jsg, GOC:mah]	PANTHER
NV2t014096001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t014096001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	InterPro
NV2t014096001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t014103001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014103001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t014103001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014103002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014103002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t014103002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014105001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014105001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t014105001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014106001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t014106001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t014106001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t014106001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t014107001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t014107001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t014107001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014107001.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	PANTHER
NV2t014107001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t014107001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t014107002.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	PANTHER
NV2t014108001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014108001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014108002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014108002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014108003.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014108003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014108004.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014108004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014109001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014109002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014109002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014110001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t014111001.1	molecular_function	GO:0003796	lysozyme activity	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan." [EC:3.2.1.17, PMID:22748813]	InterPro
NV2t014112001.1	biological_process	GO:0035600	tRNA methylthiolation	"The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640]	PANTHER
NV2t014112001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t014112002.1	biological_process	GO:0035600	tRNA methylthiolation	"The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640]	PANTHER
NV2t014112002.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t014112003.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t014112003.1	biological_process	GO:0035600	tRNA methylthiolation	"The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640]	InterPro
NV2t014112003.1	biological_process	GO:0035600	tRNA methylthiolation	"The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640]	PANTHER
NV2t014112003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014112003.1	molecular_function	GO:0016782	transferase activity, transferring sulphur-containing groups	"Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t014112003.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t014112003.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t014112003.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t014112003.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t014115001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014115001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014115001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014121001.1	biological_process	GO:0007606	sensory perception of chemical stimulus	"The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]	PANTHER
NV2t014121001.1	biological_process	GO:0050909	sensory perception of taste	"The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai]	InterPro
NV2t014121001.1	molecular_function	GO:0008527	taste receptor activity	"Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]	OMA
NV2t014122001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014122001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	InterPro
NV2t014122001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	OMA
NV2t014122001.1	biological_process	GO:0006625	protein targeting to peroxisome	"The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]	OMA
NV2t014122001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t014122001.1	biological_process	GO:0019217	regulation of fatty acid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]	OMA
NV2t014122001.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	InterPro
NV2t014122001.1	biological_process	GO:0031329	regulation of cellular catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t014122001.1	biological_process	GO:0050994	regulation of lipid catabolic process	"Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]	OMA
NV2t014122001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t014122001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t014122001.1	molecular_function	GO:0002020	protease binding	"Binding to a protease or a peptidase." [GOC:hjd]	OMA
NV2t014122001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t014122001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014122001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014122001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t014122002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014122002.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	InterPro
NV2t014122002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014122003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014122003.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	InterPro
NV2t014122003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014122004.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	InterPro
NV2t014122004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014125001.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t014125001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	OMA
NV2t014125001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t014125001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t014125001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t014125001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014125001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014125001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t014125001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t014125001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	OMA
NV2t014125001.1	molecular_function	GO:0140358	P-type transmembrane transporter activity	"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]	InterPro
NV2t014125001.1	molecular_function	GO:0140358	P-type transmembrane transporter activity	"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]	OMA
NV2t014125001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t014126001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t014126001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t014126001.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	OMA
NV2t014126001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	OMA
NV2t014126001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t014126002.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t014132001.1	biological_process	GO:0001510	RNA methylation	"Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd, PMID:21823225]	OMA
NV2t014132001.1	biological_process	GO:0009452	7-methylguanosine RNA capping	"The sequence of enzymatic reactions by which the RNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:vw, PMID:9266685]	OMA
NV2t014132001.1	biological_process	GO:0106005	RNA 5'-cap (guanine-N7)-methylation	"The process whereby a guanine in 5-cap is methylated at the N7 position of guanine." [GOC:hjd]	InterPro
NV2t014132001.1	cellular_component	GO:0034518	RNA cap binding complex	"A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation." [GOC:mah]	OMA
NV2t014132001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t014132001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014134001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t014134001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014134001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t014134001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014136001.1	biological_process	GO:0001508	action potential	"A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]	OMA
NV2t014136001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t014136001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t014136001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t014136001.1	biological_process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t014136001.1	biological_process	GO:0007212	dopamine receptor signaling pathway	"The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah, PMID:21711983]	OMA
NV2t014136001.1	biological_process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194]	OMA
NV2t014136001.1	biological_process	GO:0007215	glutamate receptor signaling pathway	"The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252]	OMA
NV2t014136001.1	biological_process	GO:0007603	phototransduction, visible light	"The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014136001.1	biological_process	GO:0009649	entrainment of circadian clock	"The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid]	OMA
NV2t014136001.1	biological_process	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	OMA
NV2t014136001.1	biological_process	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	OMA
NV2t014136001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t014136001.1	biological_process	GO:0048583	regulation of response to stimulus	"Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t014136001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t014136001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014136001.1	cellular_component	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	OMA
NV2t014136001.1	cellular_component	GO:0097733	photoreceptor cell cilium	"A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment." [GOC:cilia, Wikipedia:Photoreceptor_cell#Histology]	OMA
NV2t014136001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t014136001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t014136001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t014136001.1	molecular_function	GO:0019001	guanyl nucleotide binding	"Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t014136001.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t014136001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t014136002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t014136002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t014136002.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t014136003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t014136003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t014136003.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t014136004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t014136004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t014136004.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t014137001.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t014137001.1	biological_process	GO:0006564	L-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	InterPro
NV2t014137001.1	biological_process	GO:0009070	serine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t014137001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014137001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t014137001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t014137001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t014137001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t014137002.1	biological_process	GO:0006564	L-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	InterPro
NV2t014137002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t014138001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014138001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t014138002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014138002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t014138003.1	biological_process	GO:0007162	negative regulation of cell adhesion	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]	OMA
NV2t014138003.1	biological_process	GO:0010810	regulation of cell-substrate adhesion	"Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]	OMA
NV2t014138003.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t014138003.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	OMA
NV2t014138003.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t014138003.1	biological_process	GO:1904950	negative regulation of establishment of protein localization	"Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t014138003.1	biological_process	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t014138003.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t014138003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014138003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014138003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t014138003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t014140001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014141001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t014141001.1	biological_process	GO:0008544	epidermis development	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]	OMA
NV2t014141001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t014141001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t014141001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t014141001.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	OMA
NV2t014141001.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t014141001.1	biological_process	GO:0050658	RNA transport	"The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t014141001.1	cellular_component	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	OMA
NV2t014141001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	OMA
NV2t014141001.1	cellular_component	GO:0071204	histone pre-mRNA 3'end processing complex	"A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1." [GOC:mah, PMID:19470752]	OMA
NV2t014141001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014141001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t014141001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t014141001.1	molecular_function	GO:0035198	miRNA binding	"Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]	OMA
NV2t014141002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t014141002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014141003.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t014141003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014142001.1	biological_process	GO:0006353	DNA-templated transcription termination	"The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template." [GOC:txnOH, PMID:15020047, PMID:18280161, PMID:30978344]	OMA
NV2t014142001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t014142001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t014142001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t014142001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t014142001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t014142001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t014142001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t014143001.1	biological_process	GO:0017185	peptidyl-lysine hydroxylation	"The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai]	PANTHER
NV2t014143001.1	biological_process	GO:0018126	protein hydroxylation	"The addition of a hydroxy group to a protein amino acid." [GOC:ai]	OMA
NV2t014143001.1	biological_process	GO:0018205	peptidyl-lysine modification	"The modification of peptidyl-lysine." [GOC:go_curators]	OMA
NV2t014143001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t014143001.1	biological_process	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t014143001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t014143001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014143001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t014143001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t014143001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t014143001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t014143001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t014143001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t014143001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t014143001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t014143001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t014143002.1	biological_process	GO:0017185	peptidyl-lysine hydroxylation	"The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai]	PANTHER
NV2t014143003.1	biological_process	GO:0017185	peptidyl-lysine hydroxylation	"The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai]	PANTHER
NV2t014143003.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t014143004.1	biological_process	GO:0017185	peptidyl-lysine hydroxylation	"The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai]	PANTHER
NV2t014143004.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t014146001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014146005.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014148001.1	biological_process	GO:0006821	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	PANTHER
NV2t014148001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014148002.1	biological_process	GO:0006821	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	PANTHER
NV2t014148002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014148003.1	biological_process	GO:0006821	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	PANTHER
NV2t014148003.1	biological_process	GO:0010566	regulation of ketone biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]	OMA
NV2t014148003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014148003.1	biological_process	GO:0090030	regulation of steroid hormone biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]	OMA
NV2t014148003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014148003.1	molecular_function	GO:0005247	voltage-gated chloride channel activity	"Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014148004.1	biological_process	GO:0006821	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	PANTHER
NV2t014148004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014155001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014156001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014157001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t014157001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t014157001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t014157001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t014157001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014157001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014157001.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	InterPro
NV2t014157001.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	PANTHER
NV2t014157001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t014158001.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t014158001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014158001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014158001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014158002.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t014158002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014158002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014158002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014158003.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t014158003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014158003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014158003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014158004.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t014158004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014158004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014158004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014158005.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t014158005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014158005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014158005.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014158007.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t014158007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014158007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014158007.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014158008.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t014158008.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014158008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014158008.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014162001.1	biological_process	GO:0006909	phagocytosis	"A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]	OMA
NV2t014162001.1	biological_process	GO:0042742	defense response to bacterium	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]	OMA
NV2t014162001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014162001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	PANTHER
NV2t014162001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014163001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	PANTHER
NV2t014163001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014165001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014165001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014167001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t014167001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t014167001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t014167001.1	biological_process	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	OMA
NV2t014167001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t014167001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t014167001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t014167001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014167001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t014169001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t014171001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014171001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014171001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014171001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014171001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t014172001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014172001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t014172001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014172001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t014173001.1	cellular_component	GO:0097038	perinuclear endoplasmic reticulum	"The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]	PANTHER
NV2t014173001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t014173001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t014175001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t014176001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t014177001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	PANTHER
NV2t014177001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t014179001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t014179001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t014179001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	PANTHER
NV2t014179001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t014179001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t014181001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t014182001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014183002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014183002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014183002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t014183002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t014184001.1	biological_process	GO:0006621	protein retention in ER lumen	"The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]	OMA
NV2t014184001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t014184001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t014184001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014184001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t014184002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014184002.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t014184003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014184003.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t014185001.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t014185001.1	biological_process	GO:0009953	dorsal/ventral pattern formation	"The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t014185001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t014185001.1	biological_process	GO:0030514	negative regulation of BMP signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]	OMA
NV2t014185001.1	biological_process	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	OMA
NV2t014185001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t014185001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t014185001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t014185001.1	biological_process	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	OMA
NV2t014185001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t014185001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014185001.1	molecular_function	GO:0036122	BMP binding	"Binding to a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951]	OMA
NV2t014185001.1	molecular_function	GO:0036122	BMP binding	"Binding to a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951]	PANTHER
NV2t014186001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014186001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t014186002.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t014186002.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t014186002.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t014186002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014186002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014186002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t014186002.1	molecular_function	GO:0050062	long-chain-fatty-acyl-CoA reductase activity	"Catalysis of the reaction: a long-chain fatty aldehyde + CoA + NADP+ = a long-chain fatty acyl-CoA + NADPH." [RHEA:15437]	OMA
NV2t014186003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t014187001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t014187001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t014187001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014187001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t014187001.1	biological_process	GO:0042752	regulation of circadian rhythm	"Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]	OMA
NV2t014187001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t014187001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t014187001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014187001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t014187001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014187001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t014187001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t014187002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014187002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t014187002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014187003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014187003.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t014187003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014189001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014189001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014189002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014189002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014191001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t014191001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t014191001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t014191001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014191001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014191001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t014192001.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t014192001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t014192001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t014192001.1	biological_process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	"The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels." [GOC:curators]	OMA
NV2t014192001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t014192001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t014192001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t014192001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t014192001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t014192001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014192001.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	OMA
NV2t014192001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t014192001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014192001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t014192001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t014192001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t014192002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t014195001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t014195001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014195001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t014195001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t014195001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014196001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014198001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t014198001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014198002.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t014198002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014199001.1	biological_process	GO:0007267	cell-cell signaling	"Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah]	OMA
NV2t014199001.1	biological_process	GO:0007631	feeding behavior	"Behavior associated with the intake of food." [GOC:mah]	OMA
NV2t014199001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014199001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014199001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t014199001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t014199001.1	molecular_function	GO:0042923	neuropeptide binding	"Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]	OMA
NV2t014200001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014200001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014200002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014200002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014200002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014201001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t014201001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014201001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t014201001.1	biological_process	GO:0031056	obsolete regulation of histone modification	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]	OMA
NV2t014201001.1	biological_process	GO:0035522	obsolete monoubiquitinated histone H2A deubiquitination	"OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]	OMA
NV2t014201001.1	biological_process	GO:0043966	obsolete histone H3 acetylation	"OBSOLETE. The modification of histone H3 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t014201001.1	biological_process	GO:0051302	regulation of cell division	"Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]	OMA
NV2t014201001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t014201001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t014201001.1	cellular_component	GO:0016591	RNA polymerase II, holoenzyme	"A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii]	OMA
NV2t014201001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t014201001.1	cellular_component	GO:0140672	ATAC complex	"A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation." [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424]	OMA
NV2t014201001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t014201001.1	molecular_function	GO:0016922	nuclear receptor binding	"Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974]	OMA
NV2t014201001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t014202001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014202003.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014204001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t014204001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014204001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014204001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014204001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t014204001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t014204002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t014204002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t014204003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t014204003.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t014204004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t014204004.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t014205001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014205001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014206001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014206001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014206002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014206002.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014207001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014207001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t014207001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t014207002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014207002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t014208001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t014209001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t014209001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014209002.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t014209002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014209003.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t014209003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014209004.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t014209004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014209005.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t014209005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014209006.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t014209006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014210001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t014212001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t014212001.1	biological_process	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	OMA
NV2t014212001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014212001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014214001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014214001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t014214001.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	InterPro
NV2t014214001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t014214003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014214003.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t014214003.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	InterPro
NV2t014214003.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t014214004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014214004.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t014214004.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	InterPro
NV2t014214004.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t014215001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	PANTHER
NV2t014215002.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	PANTHER
NV2t014216001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t014216001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t014216001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t014216001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t014216001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t014216001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t014216001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014217001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t014217001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014217001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014217001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014217001.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	OMA
NV2t014217001.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	PANTHER
NV2t014218001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t014218001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	OMA
NV2t014218001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t014218001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t014218001.1	biological_process	GO:0019405	alditol catabolic process	"The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]	OMA
NV2t014218001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t014218001.1	biological_process	GO:0046166	glyceraldehyde-3-phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai]	PANTHER
NV2t014218001.1	biological_process	GO:0046184	aldehyde biosynthetic process	"The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t014218001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t014218001.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t014218001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014218001.1	molecular_function	GO:0004807	triose-phosphate isomerase activity	"Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18585]	InterPro
NV2t014218001.1	molecular_function	GO:0004807	triose-phosphate isomerase activity	"Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18585]	OMA
NV2t014218001.1	molecular_function	GO:0016835	carbon-oxygen lyase activity	"Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]	OMA
NV2t014220001.1	biological_process	GO:0017187	peptidyl-glutamic acid carboxylation	"The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]	InterPro
NV2t014220001.1	biological_process	GO:0017187	peptidyl-glutamic acid carboxylation	"The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]	OMA
NV2t014220001.1	molecular_function	GO:0008488	gamma-glutamyl carboxylase activity	"Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194]	OMA
NV2t014220001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	PANTHER
NV2t014221001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014221002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014221003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014221005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014222001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014222001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014222002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t014222002.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t014222002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014222002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014222002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014227001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014227001.1	cellular_component	GO:0016580	obsolete Sin3 complex	"OBSOLETE. A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422]	PANTHER
NV2t014228001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014228001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t014230001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014230001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014230001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t014230001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014230001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014231001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014231002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014231003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014231004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014232001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t014232002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t014233001.1	molecular_function	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	InterPro
NV2t014233001.1	molecular_function	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	OMA
NV2t014234001.1	biological_process	GO:0045901	positive regulation of translational elongation	"Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]	InterPro
NV2t014234001.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	InterPro
NV2t014234002.1	biological_process	GO:0045901	positive regulation of translational elongation	"Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]	InterPro
NV2t014234002.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	InterPro
NV2t014234003.1	biological_process	GO:0043243	positive regulation of protein-containing complex disassembly	"Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]	OMA
NV2t014234003.1	biological_process	GO:0045901	positive regulation of translational elongation	"Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]	InterPro
NV2t014234003.1	biological_process	GO:0045901	positive regulation of translational elongation	"Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]	OMA
NV2t014234003.1	biological_process	GO:0045905	positive regulation of translational termination	"Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]	InterPro
NV2t014234003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014234003.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t014234003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014234003.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t014234003.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t014235001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t014235001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t014235001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014235001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t014235002.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t014235002.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t014236001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t014236001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t014236001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014236001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t014236001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014236001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t014236001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t014236001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t014236001.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t014236001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t014236001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t014236001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t014238001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014238001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t014238001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014251001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t014251001.1	biological_process	GO:0002253	activation of immune response	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t014251001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014251001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014251001.1	biological_process	GO:0006956	complement activation	"Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149]	InterPro
NV2t014251001.1	biological_process	GO:0006959	humoral immune response	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]	OMA
NV2t014251001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t014251001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t014251001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014251001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t014251001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014251001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014252001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t014254001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t014254001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014254001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t014254001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t014255001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t014255001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014255001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014255001.1	cellular_component	GO:0033588	elongator holoenzyme complex	"A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]	InterPro
NV2t014255001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t014255001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t014255001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t014257001.1	molecular_function	GO:0010945	coenzyme A diphosphatase activity	"Catalysis of the reaction:an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine. This reaction can also use coenzyme A as a substrate." [PMID:10922370, PMID:16185196, RHEA:50044]	InterPro
NV2t014257001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t014258001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t014258001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t014258001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014258001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t014258001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t014258001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014258001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t014261001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014261001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014261001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014261002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014261002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t014267002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267002.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t014267003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267003.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t014267004.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267004.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t014267005.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267006.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267006.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t014267007.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267007.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t014267008.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267008.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t014267009.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267010.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014267010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014267010.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t014272001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t014272001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014272001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014272001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t014272001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t014272001.1	molecular_function	GO:0140103	catalytic activity, acting on a glycoprotein	"Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t014273001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014273001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t014273002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t014273003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014273003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t014273004.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t014273004.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t014273004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014273004.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t014273004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014273004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014273004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t014273004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t014276001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t014276001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t014276001.1	cellular_component	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t014278001.1	biological_process	GO:0006544	glycine metabolic process	"The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]	OMA
NV2t014278001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t014278001.1	biological_process	GO:0006637	acyl-CoA metabolic process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]	OMA
NV2t014278001.1	biological_process	GO:0006694	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	OMA
NV2t014278001.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t014278001.1	biological_process	GO:1901617	organic hydroxy compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t014278001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t014278001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014278001.1	molecular_function	GO:0016410	N-acyltransferase activity	"Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t014278001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	InterPro
NV2t014278001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t014278001.1	molecular_function	GO:0047617	fatty acyl-CoA hydrolase activity	"Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+." [RHEA:16781]	PANTHER
NV2t014279001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014279001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t014279001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014279002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014279002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t014279002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014279003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014279003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t014279003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014285001.1	cellular_component	GO:0043541	UDP-N-acetylglucosamine transferase complex	"A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis." [GOC:rn, PMID:19129246]	PANTHER
NV2t014285001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t014286001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t014286001.1	biological_process	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]	InterPro
NV2t014286001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t014286001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t014288001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	InterPro
NV2t014288001.1	molecular_function	GO:0070773	protein-N-terminal glutamine amidohydrolase activity	"Catalysis of the reaction: N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein." [PMID:19560421, RHEA:50680]	InterPro
NV2t014289001.1	biological_process	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]	InterPro
NV2t014289001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t014289002.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t014289002.1	biological_process	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]	InterPro
NV2t014289002.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t014289002.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t014289002.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t014291001.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	OMA
NV2t014291001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014291001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014291001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t014291002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014292001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014292001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014293001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t014293002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t014293003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t014293004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t014294001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014294001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	InterPro
NV2t014294001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t014294001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014294001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t014294001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014294001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014294001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014296001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t014297001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014297001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t014297001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t014297001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t014297001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t014297001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t014297001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t014297001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014297001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014297001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014297001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014298001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014298001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014298001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t014298002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014298003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014299001.1	biological_process	GO:0006177	GMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]	InterPro
NV2t014299001.1	biological_process	GO:0006177	GMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732]	PANTHER
NV2t014299001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014299001.1	biological_process	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014299001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014299001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014299001.1	molecular_function	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	"Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532]	OMA
NV2t014300001.1	biological_process	GO:0035498	carnosine metabolic process	"The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine)." [PMID:20097752]	PANTHER
NV2t014300001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t014302001.1	biological_process	GO:0006865	amino acid transport	"The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t014302001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014302001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014302001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014302001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014302002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014302002.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014302003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014302003.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014302004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014302004.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014304001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t014304001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	InterPro
NV2t014304001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	OMA
NV2t014305001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014305002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014305003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014305004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014305005.1	biological_process	GO:1901642	nucleoside transmembrane transport	"The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie]	InterPro
NV2t014307001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	OMA
NV2t014307001.1	biological_process	GO:0030261	chromosome condensation	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]	InterPro
NV2t014307001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014307001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014307002.1	biological_process	GO:0030261	chromosome condensation	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]	InterPro
NV2t014307002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014309001.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	OMA
NV2t014309001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t014309001.1	biological_process	GO:0046164	alcohol catabolic process	"The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]	OMA
NV2t014309001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t014309001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t014309001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t014309001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t014309001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014309001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t014309001.1	molecular_function	GO:0033781	cholesterol 24-hydroxylase activity	"Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]	PANTHER
NV2t014309002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t014309002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014309002.1	molecular_function	GO:0033781	cholesterol 24-hydroxylase activity	"Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]	PANTHER
NV2t014310001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t014310001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014310001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014310002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t014310002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014310002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014310003.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t014310003.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t014310003.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t014310003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014310003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014310003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014311001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014311001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t014312001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t014312001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t014312001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t014312001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014312001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014312001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014313001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t014313001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t014313001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014314001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014314001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014314001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014316001.1	biological_process	GO:0042462	eye photoreceptor cell development	"Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981]	OMA
NV2t014316001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014317001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t014317001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014317001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t014317002.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t014317002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014317002.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t014317003.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t014317003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014317003.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t014317004.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t014317004.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	OMA
NV2t014317004.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t014317004.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t014317004.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t014317005.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t014317005.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t014318001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	OMA
NV2t014318001.1	biological_process	GO:0016560	protein import into peroxisome matrix, docking	"The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507]	PANTHER
NV2t014318001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t014318001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014318001.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t014318001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014318002.1	biological_process	GO:0016560	protein import into peroxisome matrix, docking	"The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507]	PANTHER
NV2t014318002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014319003.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	OMA
NV2t014319003.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t014319003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014319003.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t014319003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014319003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014319004.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t014319004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014319005.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t014319005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014319006.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t014319006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014319007.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t014319007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014319008.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t014319008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014319009.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t014321001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t014321001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014321001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014321002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t014321002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014328001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014328001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014328001.1	molecular_function	GO:0030619	U1 snRNA binding	"Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah]	PANTHER
NV2t014328002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t014328002.1	biological_process	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	OMA
NV2t014328002.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t014328002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014328002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014328002.1	molecular_function	GO:0030619	U1 snRNA binding	"Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah]	OMA
NV2t014328002.1	molecular_function	GO:0030619	U1 snRNA binding	"Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah]	PANTHER
NV2t014328002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t014328003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014328003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014328003.1	molecular_function	GO:0030619	U1 snRNA binding	"Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah]	PANTHER
NV2t014329001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014329001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t014330001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014330001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014330001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t014330001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t014330001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t014332001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014333001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014333001.1	biological_process	GO:0006956	complement activation	"Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149]	InterPro
NV2t014333002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014334001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t014334002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t014338001.1	biological_process	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	PANTHER
NV2t014338001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014341001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t014341001.1	biological_process	GO:0006672	ceramide metabolic process	"The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]	OMA
NV2t014341001.1	biological_process	GO:0030149	sphingolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t014341001.1	biological_process	GO:0030149	sphingolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t014341001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t014341001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	OMA
NV2t014341001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014341001.1	molecular_function	GO:0008117	sphinganine-1-phosphate aldolase activity	"Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27]	OMA
NV2t014341001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t014341001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t014342001.1	biological_process	GO:0034312	diol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah]	OMA
NV2t014342001.1	biological_process	GO:1902653	secondary alcohol biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t014342001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014342001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014342001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t014343001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014343001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014343001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t014343001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t014343001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t014345001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t014348001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014348001.1	biological_process	GO:0034030	ribonucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t014348001.1	biological_process	GO:0034033	purine nucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t014348001.1	biological_process	GO:0034035	purine ribonucleoside bisphosphate metabolic process	"The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t014348001.1	biological_process	GO:0043436	oxoacid metabolic process	"The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]	OMA
NV2t014348001.1	biological_process	GO:0044272	sulfur compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]	OMA
NV2t014348001.1	biological_process	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	"The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732]	PANTHER
NV2t014348001.1	molecular_function	GO:0004781	sulfate adenylyltransferase (ATP) activity	"Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4]	InterPro
NV2t014348001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014348001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014348001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t014348001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t014348001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t014348001.1	molecular_function	GO:0070566	adenylyltransferase activity	"Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]	OMA
NV2t014349001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014349001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014349001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014350001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014350001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t014350002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014350002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t014351002.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t014351002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t014351002.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t014352001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t014352001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014352001.1	molecular_function	GO:0015103	inorganic anion transmembrane transporter activity	"Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t014352001.1	molecular_function	GO:1901702	salt transmembrane transporter activity	"Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t014352002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014353001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014354001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014354001.1	biological_process	GO:0051306	mitotic sister chromatid separation	"The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai]	InterPro
NV2t014355001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t014355001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t014355001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t014355001.1	biological_process	GO:0007040	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	OMA
NV2t014355001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t014355001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t014355001.1	biological_process	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]	OMA
NV2t014355001.1	biological_process	GO:0048284	organelle fusion	"The creation of a single organelle from two or more organelles." [GOC:jid]	OMA
NV2t014355001.1	biological_process	GO:0048284	organelle fusion	"The creation of a single organelle from two or more organelles." [GOC:jid]	PANTHER
NV2t014355001.1	biological_process	GO:2000300	regulation of synaptic vesicle exocytosis	"Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]	OMA
NV2t014355001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t014355001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t014355001.1	cellular_component	GO:0030897	HOPS complex	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]	OMA
NV2t014355001.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	OMA
NV2t014355001.1	cellular_component	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	OMA
NV2t014355001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t014355001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t014355001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t014356001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014356001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014356001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014356001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014356001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014356001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014356001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014357001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014357001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t014357001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014357001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014357002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014357002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t014357002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014357002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014359001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014359001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014361001.1	biological_process	GO:0046487	glyoxylate metabolic process	"The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]	OMA
NV2t014361001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014361001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t014361001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t014361001.1	molecular_function	GO:0030267	glyoxylate reductase (NADPH) activity	"Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [RHEA:10992]	PANTHER
NV2t014361001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t014361001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t014361001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t014361001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t014362001.1	biological_process	GO:0014070	response to organic cyclic compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:ef]	OMA
NV2t014362001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	OMA
NV2t014362001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014362001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t014362001.1	molecular_function	GO:0005452	solute:inorganic anion antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)." [GOC:mah]	OMA
NV2t014362001.1	molecular_function	GO:0015605	organophosphate ester transmembrane transporter activity	"Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc]	OMA
NV2t014362001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014362001.1	molecular_function	GO:0061513	glucose 6-phosphate:phosphate antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [GOC:dph, PMID:18337460]	PANTHER
NV2t014362001.1	molecular_function	GO:1901505	carbohydrate derivative transmembrane transporter activity	"Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t014363001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t014363001.1	biological_process	GO:0010212	response to ionizing radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]	OMA
NV2t014363001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t014363001.1	biological_process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	"A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle]	OMA
NV2t014363001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	InterPro
NV2t014363001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t014363001.1	biological_process	GO:2000001	regulation of DNA damage checkpoint	"Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]	OMA
NV2t014363001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014363001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t014363001.1	molecular_function	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	OMA
NV2t014363001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014363001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014363001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t014365001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014365001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t014365001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014365001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014366001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t014366001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t014367001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t014367001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t014368001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014368001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014368002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014368002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014368002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014368002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014368003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014368003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014369001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t014369001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014371001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t014371001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014371001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014371001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t014371001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t014376001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014376002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014376003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014376004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014376005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014377001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014379001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t014379001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t014379001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014379001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t014379001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t014379001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t014379001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t014380001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014380001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014380001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t014381001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014381001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014381001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t014381001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014382001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t014382001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	InterPro
NV2t014383001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t014383001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	InterPro
NV2t014384001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t014385001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014385001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014385001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t014385001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014385001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014387001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t014387001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t014387001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014387001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t014387001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014390001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t014393001.1	biological_process	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]	PANTHER
NV2t014393001.1	molecular_function	GO:0070569	uridylyltransferase activity	"Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]	InterPro
NV2t014393001.1	molecular_function	GO:0070569	uridylyltransferase activity	"Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]	OMA
NV2t014394001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t014394001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014395001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t014395001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t014395001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t014395001.1	cellular_component	GO:0005672	transcription factor TFIIA complex	"A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669]	OMA
NV2t014396001.1	biological_process	GO:0006384	transcription initiation at RNA polymerase III promoter	"A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]	InterPro
NV2t014397001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014397001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014397001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t014399001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014400001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014400001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014400001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014401001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014401001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014401001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014405001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014405001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014405001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t014405002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014405002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014405002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t014405003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014405003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014405003.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t014405004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014405004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014405004.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t014405004.1	biological_process	GO:0044248	cellular catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t014405004.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t014405004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014405004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014405004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014405004.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t014405004.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t014405004.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t014408001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t014408001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	PANTHER
NV2t014408001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014408001.1	molecular_function	GO:0032542	sulfiredoxin activity	"Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934]	OMA
NV2t014415001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014415001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t014415001.1	biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]	InterPro
NV2t014415001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t014415001.1	biological_process	GO:0031532	obsolete actin cytoskeleton reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]	OMA
NV2t014415001.1	biological_process	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t014415001.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	OMA
NV2t014415001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t014415001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t014415001.1	molecular_function	GO:0005154	epidermal growth factor receptor binding	"Binding to an epidermal growth factor receptor." [GOC:ai]	OMA
NV2t014415001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014415001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014416001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014416001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014416002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014416002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014416002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014416002.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t014417001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014417001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014417002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014417002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014418001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t014418001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t014418001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t014418001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014418001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014418001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t014418001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014418001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014418001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014419001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014419001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t014419001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014420001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014420001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t014421001.1	biological_process	GO:0015918	sterol transport	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]	OMA
NV2t014421001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014421001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014421001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t014421001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t014421001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t014421001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t014421001.1	molecular_function	GO:0032934	sterol binding	"Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah]	OMA
NV2t014422001.1	biological_process	GO:0016180	snRNA processing	"Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres." [PMID:15196465, PMID:31815536]	PANTHER
NV2t014425001.1	biological_process	GO:0001885	endothelial cell development	"The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]	OMA
NV2t014425001.1	biological_process	GO:0009234	menaquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]	OMA
NV2t014425001.1	biological_process	GO:0042362	fat-soluble vitamin biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]	OMA
NV2t014425001.1	biological_process	GO:0042371	vitamin K biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]	PANTHER
NV2t014425001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t014425001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t014425001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014425001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014425001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	InterPro
NV2t014425001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t014425001.1	molecular_function	GO:0016209	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	OMA
NV2t014425001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t014426001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014426001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t014426001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t014426001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t014426001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t014426001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t014426001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014426001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014426001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014427001.1	biological_process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]	OMA
NV2t014427001.1	biological_process	GO:0030210	heparin biosynthetic process	"The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]	OMA
NV2t014427001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t014427001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014427001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	OMA
NV2t014427001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t014427001.1	molecular_function	GO:0047464	heparosan-N-sulfate-glucuronate 5-epimerase activity	"Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]	InterPro
NV2t014427002.1	molecular_function	GO:0047464	heparosan-N-sulfate-glucuronate 5-epimerase activity	"Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]	InterPro
NV2t014428001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t014428001.1	biological_process	GO:0030214	hyaluronan catabolic process	"The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t014430001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t014430001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t014430001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014430001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014430001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014430001.1	molecular_function	GO:0046875	ephrin receptor binding	"Binding to an ephrin receptor." [GOC:ai]	OMA
NV2t014430002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014430002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014433001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t014433001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t014433001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014433001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t014433001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t014433001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t014433001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014434001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t014434001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t014434001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t014435001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t014435001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	OMA
NV2t014435001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t014435001.1	molecular_function	GO:0015116	sulfate transmembrane transporter activity	"Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai]	OMA
NV2t014435001.1	molecular_function	GO:0015117	thiosulfate transmembrane transporter activity	"Enables the transfer of thiosulfate ions, HS2O3(1-), from one side of a membrane to the other." [GOC:ai]	OMA
NV2t014435001.1	molecular_function	GO:0015131	oxaloacetate transmembrane transporter activity	"Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t014435001.1	molecular_function	GO:0015140	malate transmembrane transporter activity	"Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai]	OMA
NV2t014435001.1	molecular_function	GO:0015141	succinate transmembrane transporter activity	"Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t014435001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t014435001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014436001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t014436001.1	biological_process	GO:1902603	carnitine transmembrane transport	"The directed movement of carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t014436001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t014436001.1	cellular_component	GO:0005740	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	OMA
NV2t014436001.1	molecular_function	GO:0015187	glycine transmembrane transporter activity	"Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai]	OMA
NV2t014437001.1	biological_process	GO:0001952	regulation of cell-matrix adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]	OMA
NV2t014437001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t014437001.1	biological_process	GO:0007162	negative regulation of cell adhesion	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]	OMA
NV2t014437001.1	biological_process	GO:0007229	integrin-mediated signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t014437001.1	biological_process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]	OMA
NV2t014437001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t014437001.1	biological_process	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t014437001.1	biological_process	GO:0034260	negative regulation of GTPase activity	"Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649]	OMA
NV2t014437001.1	biological_process	GO:0034260	negative regulation of GTPase activity	"Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649]	PANTHER
NV2t014437001.1	biological_process	GO:0034329	cell junction assembly	"A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]	OMA
NV2t014437001.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	OMA
NV2t014437001.1	biological_process	GO:0051984	positive regulation of chromosome segregation	"Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]	OMA
NV2t014437001.1	biological_process	GO:1900024	regulation of substrate adhesion-dependent cell spreading	"Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]	OMA
NV2t014437001.1	biological_process	GO:1901889	negative regulation of cell junction assembly	"Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t014437001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014437001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t014437001.1	cellular_component	GO:0034506	chromosome, centromeric core domain	"The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw]	OMA
NV2t014437001.1	cellular_component	GO:1990023	mitotic spindle midzone	"The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t014437001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t014437001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t014437001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t014437001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t014439001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t014440001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014440001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014440001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t014440001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014441001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t014441001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t014443001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t014443001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t014443001.1	biological_process	GO:0031204	post-translational protein targeting to membrane, translocation	"The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814]	PANTHER
NV2t014443001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t014443001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t014443001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t014443001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014443001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014444001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t014444001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t014444001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t014444001.1	biological_process	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	InterPro
NV2t014444001.1	biological_process	GO:0030214	hyaluronan catabolic process	"The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t014444001.1	biological_process	GO:1903510	mucopolysaccharide metabolic process	"The chemical reactions and pathways involving mucopolysaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:4236091]	OMA
NV2t014444001.1	molecular_function	GO:0015929	hexosaminidase activity	"Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544]	OMA
NV2t014447001.1	biological_process	GO:0009231	riboflavin biosynthetic process	"The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]	InterPro
NV2t014447001.1	biological_process	GO:0009398	FMN biosynthetic process	"The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai]	PANTHER
NV2t014447002.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t014447002.1	biological_process	GO:0009156	ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014447002.1	biological_process	GO:0009231	riboflavin biosynthetic process	"The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]	InterPro
NV2t014447002.1	biological_process	GO:0009260	ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014447002.1	biological_process	GO:0009398	FMN biosynthetic process	"The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai]	PANTHER
NV2t014447002.1	biological_process	GO:0042364	water-soluble vitamin biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl]	OMA
NV2t014447002.1	biological_process	GO:0051353	positive regulation of oxidoreductase activity	"Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]	OMA
NV2t014447002.1	biological_process	GO:0052646	alditol phosphate metabolic process	"The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [PMID:30240188]	OMA
NV2t014447002.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t014447002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t014447002.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t014447002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t014447002.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t014449001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014449001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014451001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014451001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014452001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014452001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014452001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014453001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014455001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t014455001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	OMA
NV2t014455001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t014455001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t014455001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t014455001.1	biological_process	GO:0022617	extracellular matrix disassembly	"A process that results in the breakdown of the extracellular matrix." [GOC:jid]	OMA
NV2t014455001.1	cellular_component	GO:0000145	exocyst	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]	OMA
NV2t014455001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t014455001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t014455001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t014456001.1	biological_process	GO:0038166	angiotensin-activated signaling pathway	"A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869]	InterPro
NV2t014456002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t014456002.1	biological_process	GO:0038166	angiotensin-activated signaling pathway	"A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869]	InterPro
NV2t014456002.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	OMA
NV2t014456003.1	biological_process	GO:0038166	angiotensin-activated signaling pathway	"A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869]	InterPro
NV2t014457001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t014457001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t014457001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014457002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t014457002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014459001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014459001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t014459002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014459002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t014459003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t014459003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t014462001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t014462001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t014462001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t014462001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t014462001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	OMA
NV2t014462001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	PANTHER
NV2t014462001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t014462001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014463001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t014463001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014463002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t014463002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014463003.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t014463003.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t014463003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014463003.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014463004.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t014463004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014466001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t014466001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t014466001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014466001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014466001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014466001.1	molecular_function	GO:0030295	protein kinase activator activity	"Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t014466002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014467001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t014467001.1	cellular_component	GO:0033176	proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t014467001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t014468001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t014468001.1	cellular_component	GO:0071014	post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]	PANTHER
NV2t014468001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t014468001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t014468001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t014469001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t014469001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t014469001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t014469001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t014469001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t014471001.1	biological_process	GO:0000379	tRNA-type intron splice site recognition and cleavage	"RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]	PANTHER
NV2t014471002.1	biological_process	GO:0000379	tRNA-type intron splice site recognition and cleavage	"RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]	PANTHER
NV2t014472001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t014472001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t014472001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t014472001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t014472001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t014472001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t014472001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014472001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014472001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t014472001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t014472001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t014472002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t014472002.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t014472002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t014474001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014474001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014474001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014474001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014476001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014478001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014478001.1	biological_process	GO:0007094	mitotic spindle assembly checkpoint signaling	"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]	OMA
NV2t014478001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t014478001.1	biological_process	GO:0032092	positive regulation of protein binding	"Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t014478001.1	biological_process	GO:0033316	meiotic spindle assembly checkpoint signaling	"A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah]	OMA
NV2t014478001.1	biological_process	GO:0034086	maintenance of sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866]	OMA
NV2t014478001.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	OMA
NV2t014478001.1	biological_process	GO:0051304	chromosome separation	"The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243]	OMA
NV2t014478001.1	biological_process	GO:0051455	spindle attachment to meiosis I kinetochore	"The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb]	OMA
NV2t014478001.1	biological_process	GO:0051754	meiotic sister chromatid cohesion, centromeric	"The cell cycle process in which centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576]	OMA
NV2t014478001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t014478001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014478001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t014478001.1	molecular_function	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	OMA
NV2t014478001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t014478001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014478001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014479001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t014479001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t014479001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014479001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014479001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014479001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t014479002.1	biological_process	GO:0098969	neurotransmitter receptor transport to postsynaptic membrane	"The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos]	PANTHER
NV2t014479002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014479002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014479003.1	biological_process	GO:0098969	neurotransmitter receptor transport to postsynaptic membrane	"The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos]	PANTHER
NV2t014479003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014479003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014479004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t014479004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014479004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014479005.1	biological_process	GO:0098969	neurotransmitter receptor transport to postsynaptic membrane	"The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos]	PANTHER
NV2t014479005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014479005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014479006.1	biological_process	GO:0098969	neurotransmitter receptor transport to postsynaptic membrane	"The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos]	PANTHER
NV2t014479006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014479006.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014480001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t014480001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t014480001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	OMA
NV2t014480001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t014480001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t014480001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t014480001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014480001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t014480001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t014480001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t014481001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t014486001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014488001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014488001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014488001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t014488001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t014488001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t014489001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014489001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t014489001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t014492001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014493001.1	biological_process	GO:0019441	tryptophan catabolic process to kynurenine	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]	InterPro
NV2t014493001.1	biological_process	GO:0019441	tryptophan catabolic process to kynurenine	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]	OMA
NV2t014493001.1	biological_process	GO:0019441	tryptophan catabolic process to kynurenine	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]	PANTHER
NV2t014493001.1	molecular_function	GO:0004061	arylformamidase activity	"Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9]	OMA
NV2t014494001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t014494001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t014494001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014497001.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	PANTHER
NV2t014497001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014498001.1	biological_process	GO:0006882	intracellular zinc ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t014498001.1	biological_process	GO:0008286	insulin receptor signaling pathway	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]	OMA
NV2t014498001.1	biological_process	GO:0010817	regulation of hormone levels	"Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t014498001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t014498001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t014498001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t014498001.1	biological_process	GO:0033212	iron import into cell	"The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [PMID:18622392, PMID:23192658, Wikipedia:Human_iron_metabolism]	OMA
NV2t014498001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t014498001.1	biological_process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t014498001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t014498001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t014498001.1	biological_process	GO:0051346	negative regulation of hydrolase activity	"Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]	OMA
NV2t014498001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014498001.1	biological_process	GO:0061448	connective tissue development	"The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF]	OMA
NV2t014498001.1	biological_process	GO:0071333	cellular response to glucose stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]	OMA
NV2t014498001.1	biological_process	GO:0071578	zinc ion import across plasma membrane	"The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:18637840]	OMA
NV2t014498001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t014498001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t014498001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t014498001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t014498001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t014498001.1	molecular_function	GO:0005381	iron ion transmembrane transporter activity	"Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t014498001.1	molecular_function	GO:0005384	manganese ion transmembrane transporter activity	"Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t014498001.1	molecular_function	GO:0005385	zinc ion transmembrane transporter activity	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t014498001.1	molecular_function	GO:0015296	monoatomic anion:monoatomic cation symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-]	OMA
NV2t014498001.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t014499001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014499001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014499001.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t014499001.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t014500001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t014500001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	OMA
NV2t014500001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t014500001.1	molecular_function	GO:0004345	glucose-6-phosphate dehydrogenase activity	"Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49]	OMA
NV2t014500001.1	molecular_function	GO:0017057	6-phosphogluconolactonase activity	"Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+." [EC:3.1.1.31, RHEA:12556]	InterPro
NV2t014500001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t014500001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t014500001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t014502001.1	biological_process	GO:0006481	C-terminal protein methylation	"The methylation of the C-terminal amino acid of a protein." [GOC:ai]	InterPro
NV2t014502001.1	biological_process	GO:0006481	C-terminal protein methylation	"The methylation of the C-terminal amino acid of a protein." [GOC:ai]	PANTHER
NV2t014502001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014502002.1	biological_process	GO:0006481	C-terminal protein methylation	"The methylation of the C-terminal amino acid of a protein." [GOC:ai]	InterPro
NV2t014502002.1	biological_process	GO:0006481	C-terminal protein methylation	"The methylation of the C-terminal amino acid of a protein." [GOC:ai]	PANTHER
NV2t014502002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014502003.1	biological_process	GO:0006481	C-terminal protein methylation	"The methylation of the C-terminal amino acid of a protein." [GOC:ai]	InterPro
NV2t014502003.1	biological_process	GO:0006481	C-terminal protein methylation	"The methylation of the C-terminal amino acid of a protein." [GOC:ai]	PANTHER
NV2t014502003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014505001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t014505001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t014505001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014505001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014506001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t014506001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014506001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014507001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t014507001.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	InterPro
NV2t014507001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t014510001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014510002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014510003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014510005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014511001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t014511001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t014511001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t014511001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t014511001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t014522001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t014522001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014522002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t014522002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014535002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014535003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014537001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t014538001.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	OMA
NV2t014538001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014538001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014538001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t014538002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014538002.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t014538003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014538003.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t014543001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t014545001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t014545001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	PANTHER
NV2t014545001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014545001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t014545001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014545001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t014545001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t014545001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014545001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014545002.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	PANTHER
NV2t014545002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t014545002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014546001.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	InterPro
NV2t014546001.1	molecular_function	GO:0052925	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	"Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [RHEA:29527]	PANTHER
NV2t014546002.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	InterPro
NV2t014546002.1	molecular_function	GO:0052925	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	"Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [RHEA:29527]	PANTHER
NV2t014547001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t014548001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014548001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t014548001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014548002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014548002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t014548002.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t014548002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t014548002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014548002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014549001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014549001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014549001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014549002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014549002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014549003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014549003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014550001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t014551001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	OMA
NV2t014551001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014551001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t014552001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014552002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014552003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014553001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	OMA
NV2t014553001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	PANTHER
NV2t014553001.1	biological_process	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	OMA
NV2t014553001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t014556001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014559001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014559001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014559002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014559002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014562001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	PANTHER
NV2t014563001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t014563002.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t014563003.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t014563004.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t014563005.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t014564001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014564001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014565001.1	biological_process	GO:0015820	L-leucine transport	"The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t014565001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014565001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014565001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014565001.1	molecular_function	GO:0005295	neutral L-amino acid:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in)." [TC:2.A.23.3.1]	OMA
NV2t014566001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014567001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014569003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014570001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014571001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t014571001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t014571001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014572001.1	biological_process	GO:0006221	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014572001.1	biological_process	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014572001.1	biological_process	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014572001.1	biological_process	GO:0009166	nucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t014572001.1	biological_process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]	OMA
NV2t014572001.1	biological_process	GO:0046080	dUTP metabolic process	"The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]	OMA
NV2t014572001.1	biological_process	GO:0046081	dUTP catabolic process	"The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]	InterPro
NV2t014572001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t014572001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t014572001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014572001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014572001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t014572001.1	molecular_function	GO:0004170	dUTP diphosphatase activity	"Catalysis of the reaction: dUTP + H2O = dUMP + H+ + diphosphate." [RHEA:10248]	OMA
NV2t014572001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t014574001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t014574001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	PANTHER
NV2t014574001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t014574001.1	cellular_component	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	OMA
NV2t014574001.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	OMA
NV2t014575001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014575001.1	molecular_function	GO:0001409	guanine nucleotide transmembrane transporter activity	"Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other." [GOC:mcc]	OMA
NV2t014575001.1	molecular_function	GO:0005347	ATP transmembrane transporter activity	"Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t014575001.1	molecular_function	GO:0015217	ADP transmembrane transporter activity	"Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t014575001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014576001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t014576001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t014576001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t014578001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t014578001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014578001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t014578001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	PANTHER
NV2t014579001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t014579001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014579001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t014579001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	PANTHER
NV2t014580001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014581001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014581001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t014581001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t014581002.1	biological_process	GO:0035249	synaptic transmission, glutamatergic	"The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]	OMA
NV2t014581002.1	biological_process	GO:0050804	modulation of chemical synaptic transmission	"Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]	OMA
NV2t014581002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014581002.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t014581002.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t014581002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t014581002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t014581002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t014582001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	InterPro
NV2t014582002.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	InterPro
NV2t014582002.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	OMA
NV2t014582002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014583001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t014583001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t014583001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	OMA
NV2t014583001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t014583001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014583001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014583001.1	molecular_function	GO:0017147	Wnt-protein binding	"Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]	OMA
NV2t014583002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t014583002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014584001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014586001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t014586001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014588001.1	biological_process	GO:0038007	netrin-activated signaling pathway	"The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]	InterPro
NV2t014588002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t014588002.1	biological_process	GO:0038007	netrin-activated signaling pathway	"The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]	InterPro
NV2t014588003.1	biological_process	GO:0038007	netrin-activated signaling pathway	"The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]	InterPro
NV2t014588004.1	biological_process	GO:0038007	netrin-activated signaling pathway	"The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]	InterPro
NV2t014588005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t014588005.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t014588005.1	biological_process	GO:0038007	netrin-activated signaling pathway	"The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]	InterPro
NV2t014588005.1	biological_process	GO:0038007	netrin-activated signaling pathway	"The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]	OMA
NV2t014588005.1	biological_process	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t014588005.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t014588005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t014589001.1	biological_process	GO:2000766	negative regulation of cytoplasmic translation	"Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	PANTHER
NV2t014589001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014589001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014589002.1	biological_process	GO:2000766	negative regulation of cytoplasmic translation	"Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol]	PANTHER
NV2t014589002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014589002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014591001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014591001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014591001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t014591001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t014591001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014591002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014591002.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t014591002.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014591003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014591003.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t014591004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014591004.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t014591004.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014595001.1	biological_process	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t014595001.1	biological_process	GO:0043113	receptor clustering	"The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]	OMA
NV2t014595001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	OMA
NV2t014595001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t014595001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014595001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t014595001.1	cellular_component	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]	OMA
NV2t014595001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014595001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014595001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014595002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014595002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014595002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014595003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t014595003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014595003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014596001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t014596001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014596001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014598001.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t014598001.1	biological_process	GO:0042180	cellular ketone metabolic process	"The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]	OMA
NV2t014598001.1	biological_process	GO:0042446	hormone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t014598001.1	biological_process	GO:0120254	olefinic compound metabolic process	"The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc]	OMA
NV2t014598001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t014598001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	OMA
NV2t014598001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t014598001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t014598001.1	molecular_function	GO:0016832	aldehyde-lyase activity	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators]	OMA
NV2t014598001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014598001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t014598001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t014600001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014600001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014600001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t014600002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014600002.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t014601001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t014601001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014601001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014602001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t014603001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t014603001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t014603001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t014603001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t014603001.1	molecular_function	GO:0032549	ribonucleoside binding	"Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]	InterPro
NV2t014603001.1	molecular_function	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	OMA
NV2t014603001.1	molecular_function	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	OMA
NV2t014604001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t014604001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	InterPro
NV2t014604001.1	molecular_function	GO:0032549	ribonucleoside binding	"Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]	InterPro
NV2t014605001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014607001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t014607001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t014607001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t014607001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t014607001.1	molecular_function	GO:0032549	ribonucleoside binding	"Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]	InterPro
NV2t014607001.1	molecular_function	GO:0036094	small molecule binding	"Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]	OMA
NV2t014607001.1	molecular_function	GO:0097367	carbohydrate derivative binding	"Binding to a carbohydrate derivative." [GOC:pr]	OMA
NV2t014608001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t014608001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014608001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t014608001.1	cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]	OMA
NV2t014608001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t014608001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014608001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t014611001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014611001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t014611002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014611002.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t014611002.1	molecular_function	GO:0004965	G protein-coupled GABA receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]	OMA
NV2t014619001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t014619001.1	biological_process	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t014619001.1	biological_process	GO:0032228	regulation of synaptic transmission, GABAergic	"Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]	OMA
NV2t014619001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014619001.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t014619001.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t014619001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t014619001.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t014619001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t014619001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t014619001.1	molecular_function	GO:0043178	alcohol binding	"Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]	OMA
NV2t014619001.1	molecular_function	GO:0050811	GABA receptor binding	"Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai]	OMA
NV2t014619002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014619002.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t014619002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t014621001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014621001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t014621001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014621001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014621001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014621002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t014621002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014621002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014621003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t014621003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014621003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t014622001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014622001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014623001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014623001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014623001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014623001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t014623001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t014623001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t014623002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014623002.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t014627001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014627001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014629001.1	biological_process	GO:0006206	pyrimidine nucleobase metabolic process	"The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	OMA
NV2t014629001.1	biological_process	GO:0006208	pyrimidine nucleobase catabolic process	"The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	PANTHER
NV2t014629001.1	biological_process	GO:0044270	obsolete cellular nitrogen compound catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t014629001.1	biological_process	GO:0046700	obsolete heterocycle catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]	OMA
NV2t014629001.1	biological_process	GO:1901361	organic cyclic compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t014629001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t014629001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t014629001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014629001.1	molecular_function	GO:0004157	dihydropyrimidinase activity	"Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2]	OMA
NV2t014629001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t014629001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t014632001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014632001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014632001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014632001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014634001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014634001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014634001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014634001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014636001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014636001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t014636002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014636002.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t014636003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014636003.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t014637001.1	biological_process	GO:0036444	calcium import into the mitochondrion	"A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix." [GOC:vw]	OMA
NV2t014637001.1	biological_process	GO:0051560	mitochondrial calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]	OMA
NV2t014637001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t014637001.1	cellular_component	GO:0034704	calcium channel complex	"An ion channel complex through which calcium ions pass." [GOC:mah]	OMA
NV2t014637001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t014637001.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	PANTHER
NV2t014637001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014637001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014638001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t014638001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t014638001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014638001.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	InterPro
NV2t014638001.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	OMA
NV2t014638001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014638001.1	molecular_function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t014638001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t014638001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t014638001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t014640001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014640001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014640001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t014642001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014642001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	PANTHER
NV2t014642001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t014642001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t014642001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t014643001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t014643001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t014645001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t014645001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t014645001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t014645001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t014645001.1	molecular_function	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244]	OMA
NV2t014645002.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t014645002.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t014651001.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	PANTHER
NV2t014654001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t014654001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014655001.1	cellular_component	GO:0031519	PcG protein complex	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]	PANTHER
NV2t014656001.1	biological_process	GO:0015871	choline transport	"The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]	PANTHER
NV2t014656001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014656001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014656001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014657001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t014657001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014660001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	InterPro
NV2t014660001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	OMA
NV2t014660001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t014662001.1	cellular_component	GO:0016593	Cdc73/Paf1 complex	"A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]	PANTHER
NV2t014662001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014666001.1	molecular_function	GO:0052856	NADHX epimerase activity	"Catalysis of the reaction: (R)-NADHX = (S)-NADHX." [PMID:21994945]	PANTHER
NV2t014666002.1	molecular_function	GO:0052856	NADHX epimerase activity	"Catalysis of the reaction: (R)-NADHX = (S)-NADHX." [PMID:21994945]	PANTHER
NV2t014670001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t014670001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014670001.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t014670001.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t014670001.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t014670001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014670001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014670001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t014672001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014672002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014673001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014673001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t014673001.1	biological_process	GO:0110031	negative regulation of G2/MI transition of meiotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408]	PANTHER
NV2t014673001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t014673001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t014673001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014673001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014675001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014677001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t014678001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t014678001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t014678001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	PANTHER
NV2t014678001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014678001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014679001.1	biological_process	GO:0043123	positive regulation of canonical NF-kappaB signal transduction	"Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade." [GOC:jl]	PANTHER
NV2t014680001.1	biological_process	GO:0042136	obsolete neurotransmitter biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl]	OMA
NV2t014680001.1	biological_process	GO:0042417	dopamine metabolic process	"The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]	OMA
NV2t014680001.1	biological_process	GO:0042421	norepinephrine biosynthetic process	"The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t014680001.1	biological_process	GO:0042423	catecholamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]	OMA
NV2t014680001.1	biological_process	GO:0042424	catecholamine catabolic process	"The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]	OMA
NV2t014680001.1	biological_process	GO:0046165	alcohol biosynthetic process	"The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]	OMA
NV2t014680001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t014680001.1	cellular_component	GO:0030667	secretory granule membrane	"The lipid bilayer surrounding a secretory granule." [GOC:mah]	OMA
NV2t014680001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t014680001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t014680001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t014680001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t014685001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t014685001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014687001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014687001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014687001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t014687001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t014687001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t014688001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t014689001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t014689002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t014689003.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t014692001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t014695001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	OMA
NV2t014695001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014695002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014695003.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014695004.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014695005.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014695006.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014695007.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014695008.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t014700001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014700001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014700001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014700001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t014702001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014705001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t014708001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t014708001.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t014708001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t014715001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t014715001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t014718001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t014718001.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t014718001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t014718002.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t014721001.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	PANTHER
NV2t014721002.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	PANTHER
NV2t014721003.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	PANTHER
NV2t014721004.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	PANTHER
NV2t014723001.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t014723001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014723001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t014723001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014723001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014723001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t014723001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t014723001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	OMA
NV2t014723001.1	molecular_function	GO:0140358	P-type transmembrane transporter activity	"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]	InterPro
NV2t014723001.1	molecular_function	GO:0140358	P-type transmembrane transporter activity	"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]	OMA
NV2t014724001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014724002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014724003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014724004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014724005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014736001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t014736001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t014736001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	InterPro
NV2t014736001.1	molecular_function	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]	OMA
NV2t014736001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t014736001.1	molecular_function	GO:0046523	S-methyl-5-thioribose-1-phosphate isomerase activity	"Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19989]	PANTHER
NV2t014738001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t014738001.1	molecular_function	GO:0003726	double-stranded RNA adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah, RHEA:10120]	InterPro
NV2t014738001.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t014739001.1	biological_process	GO:0006605	protein targeting	"The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	OMA
NV2t014739001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t014739001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t014739001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t014739001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t014739001.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t014739001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t014739001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t014739001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t014739001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014739001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t014740001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t014740001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t014740001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014741001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t014747001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t014747001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t014747001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t014747001.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	OMA
NV2t014747001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014747001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014747001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014747001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t014747001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t014747001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014747001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014747001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014747001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t014748001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014749001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014750001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014752001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t014752001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t014752001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014753001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t014753002.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t014755001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t014755001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t014755001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t014756001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t014756001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t014756001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t014759001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014759001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014761001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t014761001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t014761001.1	biological_process	GO:0006183	GTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732]	PANTHER
NV2t014761001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t014761001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014761001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t014763001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014763001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t014763001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t014763001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014767001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t014767001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t014767001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t014768001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t014768001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014769001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	PANTHER
NV2t014772001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t014772001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014772001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014772001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014772001.1	molecular_function	GO:0008201	heparin binding	"Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t014776001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014776001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014776001.1	molecular_function	GO:0032036	myosin heavy chain binding	"Binding to a heavy chain of a myosin complex." [GOC:mah]	PANTHER
NV2t014777001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	OMA
NV2t014777001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t014777001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014777001.1	molecular_function	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl]	OMA
NV2t014777001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t014777001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t014778001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t014778001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t014778001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t014778001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t014778001.1	molecular_function	GO:1902444	riboflavin binding	"Binding to riboflavin." [GOC:TermGenie, PMID:12083520]	PANTHER
NV2t014781001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t014781001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014781001.1	molecular_function	GO:0050291	sphingosine N-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]	InterPro
NV2t014781001.1	molecular_function	GO:0050291	sphingosine N-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]	OMA
NV2t014782001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014782001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t014782001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t014782001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014782001.1	molecular_function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	"Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]	OMA
NV2t014782001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014782001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014783001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t014783001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t014783001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t014783001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t014787001.1	cellular_component	GO:0016589	NURF complex	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]	OMA
NV2t014787001.1	cellular_component	GO:0044665	MLL1/2 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t014787001.1	cellular_component	GO:0071339	MLL1 complex	"A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975]	PANTHER
NV2t014788001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014788001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014789001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	InterPro
NV2t014789001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t014789001.1	molecular_function	GO:0017022	myosin binding	"Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah]	InterPro
NV2t014789001.1	molecular_function	GO:0017022	myosin binding	"Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah]	OMA
NV2t014790001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t014790001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t014790001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t014790001.1	biological_process	GO:0010001	glial cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]	OMA
NV2t014790001.1	biological_process	GO:0019827	stem cell population maintenance	"The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]	OMA
NV2t014790001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t014790001.1	biological_process	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	OMA
NV2t014790001.1	biological_process	GO:0061157	mRNA destabilization	"Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh]	OMA
NV2t014790001.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	PANTHER
NV2t014790001.1	biological_process	GO:1901533	negative regulation of hematopoietic progenitor cell differentiation	"Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie]	OMA
NV2t014790001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014790001.1	cellular_component	GO:0036396	RNA N6-methyladenosine methyltransferase complex	"A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B)." [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715, PMID:24407421, PMID:29507755, PMID:29535189, PMID:29547716]	OMA
NV2t014790001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t014790001.1	molecular_function	GO:0008174	mRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah]	OMA
NV2t014791001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t014791001.1	cellular_component	GO:0016011	dystroglycan complex	"A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609]	OMA
NV2t014791001.1	cellular_component	GO:0016012	sarcoglycan complex	"A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]	PANTHER
NV2t014791001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014791001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014792001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t014792001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t014792001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t014792001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t014792001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t014792001.1	molecular_function	GO:0070180	large ribosomal subunit rRNA binding	"Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]	OMA
NV2t014792001.1	molecular_function	GO:0070180	large ribosomal subunit rRNA binding	"Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]	PANTHER
NV2t014793001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	InterPro
NV2t014793001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	OMA
NV2t014793001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014793001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t014794001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t014794001.1	molecular_function	GO:0140312	cargo adaptor activity	"Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]	PANTHER
NV2t014795001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014796001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014796001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t014796001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t014796001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t014796001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t014798001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014798001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014799001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t014799001.1	biological_process	GO:0019985	translesion synthesis	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]	OMA
NV2t014799001.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	InterPro
NV2t014799001.1	biological_process	GO:0070987	error-free translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh]	PANTHER
NV2t014799001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t014799001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	InterPro
NV2t014799001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	OMA
NV2t014800001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014800001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014800002.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014800002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014800003.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014800003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014800003.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t014800003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014800003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t014800004.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014800004.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014800005.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014800005.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014800006.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014800006.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014800007.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014800007.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014800008.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014800008.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014802001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014802001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014802001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014802002.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014802002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014802002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014802003.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t014802003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014802003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t014803001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014803001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t014803001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t014806001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014806001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t014807001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014807001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014807001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t014807001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014807001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014808001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014808001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014808002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014808002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014808003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014808003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014808003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014808004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014808004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014809001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014809001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014809001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014810001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014812001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014812001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014816001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014816001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014816002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014816002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014816003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014816003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014816004.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014816004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014816005.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t014816005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014818001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014818001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014818001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014820001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014820001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t014820001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t014820001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t014820001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014820001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014820001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014820001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014821001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t014821001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t014821001.1	biological_process	GO:0006687	glycosphingolipid metabolic process	"The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]	OMA
NV2t014821001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t014821001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t014821001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t014821001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t014821001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t014821001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014821001.1	molecular_function	GO:0004563	beta-N-acetylhexosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]	OMA
NV2t014822001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014822002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014822003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014822004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t014826001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t014826001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	InterPro
NV2t014826001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t014826001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t014826001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t014826001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t014828001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014828001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t014828001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014828001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014830001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014830001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014830002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014830002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t014830002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014830002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014832001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014832001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014832001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014832001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014833001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014833002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014833003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014834001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014835001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014837001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t014837001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t014837001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014837002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t014837002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t014837002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014839001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014839001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014839001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014840001.1	biological_process	GO:0006309	apoptotic DNA fragmentation	"The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]	InterPro
NV2t014840001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t014840001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t014841001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t014841001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	OMA
NV2t014841001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014841001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t014841001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t014841001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t014841001.1	molecular_function	GO:0030955	potassium ion binding	"Binding to a potassium ion (K+)." [GOC:mah]	InterPro
NV2t014844001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014845001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t014845001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t014845001.1	molecular_function	GO:0016274	protein-arginine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [GOC:mah, PMID:12351636, PMID:31284549]	OMA
NV2t014848001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t014848001.1	biological_process	GO:0045921	positive regulation of exocytosis	"Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t014848001.1	biological_process	GO:0051650	establishment of vesicle localization	"The directed movement of a vesicle to a specific location." [GOC:ai]	OMA
NV2t014848001.1	biological_process	GO:0071840	cellular component organization or biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah]	OMA
NV2t014848001.1	biological_process	GO:0098969	neurotransmitter receptor transport to postsynaptic membrane	"The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos]	PANTHER
NV2t014848001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t014848001.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	OMA
NV2t014848001.1	cellular_component	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	OMA
NV2t014848001.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	OMA
NV2t014848001.1	molecular_function	GO:0003925	G protein activity	"A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]	OMA
NV2t014848001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t014848001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t014849001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t014849001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t014849001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t014849001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t014849001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t014849001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t014849001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t014850001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t014850001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t014850002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t014850002.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t014853001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t014853001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t014853001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t014853001.1	biological_process	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	"Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos]	OMA
NV2t014853001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t014853001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014853001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t014853001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	OMA
NV2t014853001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t014853001.1	cellular_component	GO:0034518	RNA cap binding complex	"A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation." [GOC:mah]	OMA
NV2t014853001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t014853001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	OMA
NV2t014853001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t014853001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t014853001.1	molecular_function	GO:0000340	RNA 7-methylguanosine cap binding	"Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]	OMA
NV2t014853001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t014853001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t014853001.1	molecular_function	GO:0031370	eukaryotic initiation factor 4G binding	"Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t014853001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	OMA
NV2t014854001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014854001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t014854001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014854002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t014854002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t014854002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t014855001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t014855002.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t014855002.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t014855002.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t014855002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t014855003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t014857001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014858001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t014858001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014858001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t014860001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014860001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t014861001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t014861002.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t014862001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014862002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014862003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014862004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014862004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014862004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014862004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014862004.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t014862004.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t014862004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t014862004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014862004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014863001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t014863001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t014863001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t014863001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t014867001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t014867001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t014867001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t014868001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t014868001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014868001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t014874001.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	PANTHER
NV2t014874001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014874001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t014874002.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t014874002.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t014874002.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t014874002.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t014874002.1	biological_process	GO:0036089	cleavage furrow formation	"Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell." [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590]	OMA
NV2t014874002.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	OMA
NV2t014874002.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	PANTHER
NV2t014874002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014874002.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t014874002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014874002.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t014874002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t014874003.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	PANTHER
NV2t014874004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t014876001.1	biological_process	GO:0000738	obsolete DNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]	OMA
NV2t014876001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t014876001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014876001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t014876001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014876001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t014876001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t014876001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t014877001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014881001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t014889001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t014889001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014889001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014897001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t014897001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t014897001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t014897001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t014897001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t014897001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t014897001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014897001.1	molecular_function	GO:0005092	GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]	OMA
NV2t014897001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t014898001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	PANTHER
NV2t014898001.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898001.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898002.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	PANTHER
NV2t014898002.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898003.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	PANTHER
NV2t014898003.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898003.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898004.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	PANTHER
NV2t014898004.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898004.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898005.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	PANTHER
NV2t014898005.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898005.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898006.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	PANTHER
NV2t014898006.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014898006.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	InterPro
NV2t014899001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014899001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014899002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014901001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	InterPro
NV2t014901001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	OMA
NV2t014901001.1	biological_process	GO:0009313	oligosaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t014901001.1	biological_process	GO:0044275	obsolete cellular carbohydrate catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t014901001.1	biological_process	GO:0072329	monocarboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t014901001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014901001.1	molecular_function	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	"Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]	InterPro
NV2t014901001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t014901001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t014901001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t014901001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t014901001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	PANTHER
NV2t014904001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t014904001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t014905001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t014905002.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t014905003.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t014906001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014906001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014906001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014906001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014907001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t014907001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014909001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t014909001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t014909001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t014910001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	PANTHER
NV2t014910001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014910002.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	PANTHER
NV2t014910002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014911001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	InterPro
NV2t014911001.1	molecular_function	GO:0045294	alpha-catenin binding	"Binding to catenin complex alpha subunit." [GOC:bf]	PANTHER
NV2t014911001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t014913001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014913001.1	molecular_function	GO:0140801	histone H2AXY142 kinase activity	"Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX." [PMID:19092802]	InterPro
NV2t014914001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t014914001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t014914001.1	cellular_component	GO:0031010	ISWI-type complex	"Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]	OMA
NV2t014914001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t014914001.1	molecular_function	GO:0035173	histone kinase activity	"Catalysis of the transfer of a phosphate group to a histone." [GOC:bf]	OMA
NV2t014914001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t014914001.1	molecular_function	GO:0140801	histone H2AXY142 kinase activity	"Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX." [PMID:19092802]	InterPro
NV2t014914002.1	molecular_function	GO:0140801	histone H2AXY142 kinase activity	"Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX." [PMID:19092802]	InterPro
NV2t014914003.1	molecular_function	GO:0140801	histone H2AXY142 kinase activity	"Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX." [PMID:19092802]	InterPro
NV2t014914004.1	molecular_function	GO:0140801	histone H2AXY142 kinase activity	"Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX." [PMID:19092802]	InterPro
NV2t014914005.1	molecular_function	GO:0140801	histone H2AXY142 kinase activity	"Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX." [PMID:19092802]	InterPro
NV2t014915001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014916001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t014916001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t014916001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t014916001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t014916001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t014916001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t014916001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t014916001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t014917001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014917001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t014917002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014917002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t014926001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t014927002.1	biological_process	GO:0017183	protein histidyl modification to diphthamide	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380]	InterPro
NV2t014927002.1	molecular_function	GO:0090560	2-(3-amino-3-carboxypropyl)histidine synthase activity	"Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [GOC:pde, PMID:15485916]	InterPro
NV2t014927003.1	biological_process	GO:0017183	protein histidyl modification to diphthamide	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380]	InterPro
NV2t014927003.1	molecular_function	GO:0090560	2-(3-amino-3-carboxypropyl)histidine synthase activity	"Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [GOC:pde, PMID:15485916]	InterPro
NV2t014927004.1	biological_process	GO:0006448	regulation of translational elongation	"Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]	OMA
NV2t014927004.1	biological_process	GO:0017183	protein histidyl modification to diphthamide	"The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380]	InterPro
NV2t014927004.1	biological_process	GO:0018202	peptidyl-histidine modification	"The modification of peptidyl-histidine." [GOC:ma]	OMA
NV2t014927004.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t014927004.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t014927004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t014927004.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t014927004.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t014927004.1	molecular_function	GO:0090560	2-(3-amino-3-carboxypropyl)histidine synthase activity	"Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [GOC:pde, PMID:15485916]	InterPro
NV2t014928001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014928001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014928002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t014928002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014928002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014929001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t014929001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t014930001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t014931001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014931001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014931001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	PANTHER
NV2t014931006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014931006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014931006.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	PANTHER
NV2t014935001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014935001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t014935001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014935001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t014935001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	PANTHER
NV2t014937001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t014937001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t014937001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014937001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t014937001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t014937001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014938001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t014938001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t014938001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t014938001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t014938001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	PANTHER
NV2t014938001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t014938001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t014938001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t014938001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t014939001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t014939001.1	biological_process	GO:0006032	chitin catabolic process	"The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t014939001.1	biological_process	GO:0009313	oligosaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t014939001.1	biological_process	GO:0009313	oligosaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	PANTHER
NV2t014939001.1	molecular_function	GO:0004568	chitinase activity	"Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]	OMA
NV2t014939001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t014939001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t014940001.1	biological_process	GO:0002052	positive regulation of neuroblast proliferation	"Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]	OMA
NV2t014940001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014940001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t014940001.1	biological_process	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t014940001.1	biological_process	GO:0045666	positive regulation of neuron differentiation	"Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]	OMA
NV2t014940001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014940001.1	cellular_component	GO:0017053	transcription repressor complex	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]	OMA
NV2t014940001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t014940001.1	molecular_function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t014940002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014941003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t014942001.1	biological_process	GO:0006354	DNA-templated transcription elongation	"The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]	InterPro
NV2t014942001.1	biological_process	GO:0032784	regulation of DNA-templated transcription elongation	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	InterPro
NV2t014942001.1	biological_process	GO:0140673	transcription elongation-coupled chromatin remodeling	"A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation." [PMID:22922743, PMID:28053344]	InterPro
NV2t014942002.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t014942002.1	biological_process	GO:0006354	DNA-templated transcription elongation	"The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]	InterPro
NV2t014942002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t014942002.1	biological_process	GO:0032784	regulation of DNA-templated transcription elongation	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	InterPro
NV2t014942002.1	biological_process	GO:0032784	regulation of DNA-templated transcription elongation	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	OMA
NV2t014942002.1	biological_process	GO:0140673	transcription elongation-coupled chromatin remodeling	"A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation." [PMID:22922743, PMID:28053344]	InterPro
NV2t014942002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014943002.1	cellular_component	GO:0031213	RSF complex	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179]	InterPro
NV2t014944001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014944002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014946001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t014946001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t014946001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014948001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014948001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014957001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t014957001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014957002.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t014957002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014957003.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t014957003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014957004.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t014957004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014957005.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t014957005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014957006.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t014957006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014958001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t014958001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014958001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014958002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014958003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t014958003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014961001.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	OMA
NV2t014961001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t014961001.1	biological_process	GO:0046164	alcohol catabolic process	"The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]	OMA
NV2t014961001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t014961001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t014961001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t014961001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t014961001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t014961001.1	molecular_function	GO:0033781	cholesterol 24-hydroxylase activity	"Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]	InterPro
NV2t014964001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t014964001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t014964001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t014964001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t014964001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t014966001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t014966001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014968001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t014968001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t014968001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014968001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t014968001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t014969001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t014969001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t014969001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t014969001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t014969001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t014971001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t014971001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t014971001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t014971001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t014972001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t014972001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t014972001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t014972001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t014972001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t014974001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t014974001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t014974001.1	biological_process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	"Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]	PANTHER
NV2t014974001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014974002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t014974002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t014974002.1	biological_process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	"Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]	PANTHER
NV2t014974002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014974003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014976001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014977001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t014977002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014977003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014977004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014977005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014978001.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	OMA
NV2t014978001.1	biological_process	GO:0015803	branched-chain amino acid transport	"The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf]	OMA
NV2t014978001.1	biological_process	GO:0015803	branched-chain amino acid transport	"The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf]	PANTHER
NV2t014978001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t014978001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t014978001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t014978001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t014978001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t014979001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t014979001.1	biological_process	GO:0006896	Golgi to vacuole transport	"The directed movement of substances from the Golgi to the vacuole." [GOC:ai]	OMA
NV2t014979001.1	biological_process	GO:0048490	anterograde synaptic vesicle transport	"The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg]	OMA
NV2t014979001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t014979001.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	OMA
NV2t014979001.1	cellular_component	GO:0030123	AP-3 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]	InterPro
NV2t014979001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t014979001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t014985001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014985001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014985001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014985001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014986001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t014986001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t014986001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t014986001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t014986001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t014986001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t014986001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t014986001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t014986001.1	molecular_function	GO:0016018	cyclosporin A binding	"Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb]	OMA
NV2t014987001.1	biological_process	GO:0006595	polyamine metabolic process	"The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	InterPro
NV2t014987001.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	OMA
NV2t014987001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t014987001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t014987001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t014988001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t014991001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t014991001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014991001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t014991002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t014991002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t014991002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t014992001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t014992001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t014993001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t014994001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014994001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014994001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014994001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t014994001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t014995001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014995001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t014995001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014995001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t014996001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t014996001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t014996001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t015002001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t015002001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t015002001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t015002001.1	cellular_component	GO:0097542	ciliary tip	"Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]	OMA
NV2t015002001.1	cellular_component	GO:0097542	ciliary tip	"Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]	PANTHER
NV2t015002001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015004001.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t015004001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015004001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015004001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015005001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t015005001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015005002.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t015005002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015005003.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t015005003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015006001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t015006001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t015006001.1	biological_process	GO:0034058	endosomal vesicle fusion	"The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]	PANTHER
NV2t015007001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015010001.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	OMA
NV2t015010001.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	PANTHER
NV2t015010001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015010001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t015010001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t015010001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t015010002.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	PANTHER
NV2t015010002.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t015010003.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	PANTHER
NV2t015010003.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t015010004.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t015010004.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	PANTHER
NV2t015011001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015011001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t015011001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015011001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015016001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t015016001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t015016001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t015016001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t015016001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t015016001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t015018001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015018001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t015018001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015018001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015018001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015020001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015021001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t015021001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t015021002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t015021002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t015021002.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t015022001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t015022001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015022002.1	biological_process	GO:0007288	sperm axoneme assembly	"The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t015022002.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t015022002.1	biological_process	GO:0019221	cytokine-mediated signaling pathway	"The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]	OMA
NV2t015022002.1	biological_process	GO:0030534	adult behavior	"Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099]	OMA
NV2t015022002.1	biological_process	GO:0032095	regulation of response to food	"Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add]	OMA
NV2t015022002.1	biological_process	GO:0032098	regulation of appetite	"Any process which modulates appetite, the desire or physical craving for food." [GOC:add]	OMA
NV2t015022002.1	biological_process	GO:0032102	negative regulation of response to external stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t015022002.1	biological_process	GO:0032870	cellular response to hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]	OMA
NV2t015022002.1	biological_process	GO:0033365	protein localization to organelle	"A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]	OMA
NV2t015022002.1	biological_process	GO:0040015	negative regulation of multicellular organism growth	"Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]	OMA
NV2t015022002.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	OMA
NV2t015022002.1	biological_process	GO:0045494	photoreceptor cell maintenance	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]	OMA
NV2t015022002.1	biological_process	GO:0048854	brain morphogenesis	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]	OMA
NV2t015022002.1	biological_process	GO:0060295	regulation of cilium movement involved in cell motility	"Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t015022002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t015022002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t015022002.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t015022002.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t015022002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t015022002.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t015022002.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t015022002.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t015022002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015022002.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t015022003.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t015022003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015022004.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t015022004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015022005.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t015022005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015022006.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t015022006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015025001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015025001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015027001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t015028001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t015029001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t015031001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t015031001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t015031001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t015031001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t015033001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t015033001.1	molecular_function	GO:0004965	G protein-coupled GABA receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]	OMA
NV2t015033002.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t015033003.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t015037001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015037001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t015041001.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t015041001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015041001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015041001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015042001.1	biological_process	GO:0050767	regulation of neurogenesis	"Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai]	PANTHER
NV2t015042001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015043001.1	biological_process	GO:0007369	gastrulation	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]	OMA
NV2t015043001.1	biological_process	GO:0009409	response to cold	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]	OMA
NV2t015043001.1	biological_process	GO:0009411	response to UV	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]	OMA
NV2t015043001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t015043001.1	biological_process	GO:0010092	specification of animal organ identity	"The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]	OMA
NV2t015043001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t015043001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t015043001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	OMA
NV2t015043001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t015043001.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t015043001.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	OMA
NV2t015043001.1	biological_process	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening	"Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]	OMA
NV2t015043001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t015043001.1	biological_process	GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	OMA
NV2t015043001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015043001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t015043001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015043001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015043001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t015043001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t015043001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t015043001.1	molecular_function	GO:0030371	translation repressor activity	"Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt]	OMA
NV2t015043001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t015044001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015044001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015044001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015045001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t015045001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015045001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015045001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015045002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t015045002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015045002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015045003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t015045003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015045003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015048001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	OMA
NV2t015048001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t015048001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t015048001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t015049001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t015049001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t015049001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015049001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015049001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015049001.1	molecular_function	GO:0004602	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]	OMA
NV2t015051001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t015051001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015052001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t015052001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015052002.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t015052002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015053001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015055001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015056001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015056001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015056001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015058001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	OMA
NV2t015058001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t015058001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t015058001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t015059001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t015059001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015059002.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t015059002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015060001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t015060001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015064001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015064001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015064001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t015068001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015068001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015068002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015068002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015069001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t015069001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015069001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t015071001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015074001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t015074001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t015074001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t015074001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015074001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015074001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015074001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t015076001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t015076001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015076001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015076001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t015079001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015079001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015079001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015079001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t015079001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	OMA
NV2t015079001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015079001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015079001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015079001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015079001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015079001.1	molecular_function	GO:0043139	5'-3' DNA helicase activity	"Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [EC:5.6.2.3, GOC:jl]	PANTHER
NV2t015080001.1	biological_process	GO:0090069	regulation of ribosome biogenesis	"Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb]	OMA
NV2t015080001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t015080001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015080001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015080001.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	OMA
NV2t015080001.1	molecular_function	GO:0010521	telomerase inhibitor activity	"Binds to and stops, prevents or reduces the activity of telomerase." [GOC:dph, GOC:krc, GOC:tb]	PANTHER
NV2t015081001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t015081001.1	cellular_component	GO:0005685	U1 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	InterPro
NV2t015081001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t015081001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015081001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015081001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015081001.1	molecular_function	GO:0030627	pre-mRNA 5'-splice site binding	"Binding to a pre-mRNA 5' splice site sequence." [GOC:jl]	PANTHER
NV2t015083001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015083001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	PANTHER
NV2t015083001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015083001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015085001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015085002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015085003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015086001.1	biological_process	GO:0006556	S-adenosylmethionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015086002.1	biological_process	GO:0006556	S-adenosylmethionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015087001.1	biological_process	GO:0006556	S-adenosylmethionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015087001.1	biological_process	GO:0006556	S-adenosylmethionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t015087001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015087001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t015087001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t015087001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015087001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015087001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t015088001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t015088001.1	biological_process	GO:0035329	hippo signaling	"An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation." [PMID:17318211, PMID:18328423, PMID:36347846]	OMA
NV2t015088001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015088001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015088001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t015088001.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	OMA
NV2t015088001.1	molecular_function	GO:0030295	protein kinase activator activity	"Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t015088001.1	molecular_function	GO:0030295	protein kinase activator activity	"Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	PANTHER
NV2t015090001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	OMA
NV2t015090001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t015090001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t015090001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t015090001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015090001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015090001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015091001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015096001.1	biological_process	GO:0006637	acyl-CoA metabolic process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]	OMA
NV2t015096001.1	biological_process	GO:0042759	long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [PMID:18390550]	OMA
NV2t015096001.1	biological_process	GO:1900535	palmitic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of palmitic acid." [GOC:TermGenie]	PANTHER
NV2t015096001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t015096001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015096001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t015096001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t015096001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t015096001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t015096001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t015096001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t015099001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015099001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015099001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015099002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015099002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015099002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015099002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015102001.1	biological_process	GO:0006014	D-ribose metabolic process	"The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732]	InterPro
NV2t015102001.1	biological_process	GO:0019321	pentose metabolic process	"The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t015102001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t015102001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t015102001.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t015104001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015104001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015104001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015104001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015106001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015106001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015106001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015106001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015106001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t015106001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t015107001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t015107001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	OMA
NV2t015107001.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	OMA
NV2t015107001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015107001.1	cellular_component	GO:0009328	phenylalanine-tRNA ligase complex	"An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [PMID:20223217]	PANTHER
NV2t015107001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t015107001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t015107001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015107001.1	molecular_function	GO:0004826	phenylalanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]	InterPro
NV2t015107001.1	molecular_function	GO:0004826	phenylalanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]	OMA
NV2t015107001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015108001.1	molecular_function	GO:0004500	dopamine beta-monooxygenase activity	"Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]	InterPro
NV2t015108002.1	biological_process	GO:0042421	norepinephrine biosynthetic process	"The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t015108002.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t015109001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t015109001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015110001.1	molecular_function	GO:0015297	antiporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t015111001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t015111001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015112002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015112002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015113001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t015113001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t015113001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t015113001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t015113001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t015113001.1	molecular_function	GO:0016408	C-acyltransferase activity	"Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]	OMA
NV2t015113001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t015113001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t015116001.1	biological_process	GO:0007088	regulation of mitotic nuclear division	"Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]	OMA
NV2t015116001.1	biological_process	GO:0032147	activation of protein kinase activity	"Any process that initiates the activity of an inactive protein kinase." [GOC:mah]	OMA
NV2t015116001.1	biological_process	GO:0060236	regulation of mitotic spindle organization	"Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t015116001.1	biological_process	GO:0060236	regulation of mitotic spindle organization	"Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t015116001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015116001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015116001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t015118002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015120001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015120001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015123001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t015123001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t015123001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t015126001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t015126001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t015126001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t015128001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015128001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t015128001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015128001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t015128001.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	InterPro
NV2t015128001.1	molecular_function	GO:0016427	tRNA (cytidine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [GOC:go-curators]	OMA
NV2t015133001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	InterPro
NV2t015133001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t015133001.1	molecular_function	GO:0030695	GTPase regulator activity	"Binds to and modulates the activity of a GTPase." [GOC:mah]	InterPro
NV2t015135001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015135001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t015135002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015135002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t015136001.1	cellular_component	GO:0061617	MICOS complex	"Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]	InterPro
NV2t015136001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t015137001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t015137001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t015137001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t015137001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015137002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t015137002.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t015137002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015137003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t015137003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t015137003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015142001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015142001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t015142001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015144001.1	biological_process	GO:0042407	cristae formation	"The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t015148001.1	biological_process	GO:0031532	obsolete actin cytoskeleton reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]	OMA
NV2t015148001.1	biological_process	GO:0031532	obsolete actin cytoskeleton reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]	PANTHER
NV2t015148001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015150001.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t015150001.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	OMA
NV2t015150001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t015150001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t015150001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t015150001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t015150001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t015150001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t015150001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015150001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015150001.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	OMA
NV2t015150001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t015150001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t015150001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t015150001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t015150001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t015152001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t015152002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t015153001.1	biological_process	GO:0006405	RNA export from nucleus	"The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t015153001.1	biological_process	GO:0006408	snRNA export from nucleus	"The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma]	InterPro
NV2t015154001.1	biological_process	GO:0071039	nuclear polyadenylation-dependent CUT catabolic process	"The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258]	PANTHER
NV2t015154001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015154002.1	biological_process	GO:0071039	nuclear polyadenylation-dependent CUT catabolic process	"The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258]	PANTHER
NV2t015154002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015154003.1	biological_process	GO:0071039	nuclear polyadenylation-dependent CUT catabolic process	"The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258]	PANTHER
NV2t015154003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015158001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t015158001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015158001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015158001.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t015158001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015158001.1	cellular_component	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t015158001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015158001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015158001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015158001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t015158002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015158002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015159001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015159001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015159001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t015159002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015159002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015159002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t015160001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015160001.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t015160001.1	cellular_component	GO:0043527	tRNA methyltransferase complex	"A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972]	PANTHER
NV2t015160001.1	molecular_function	GO:0008176	tRNA (guanine(46)-N7)-methyltransferase activity	"Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine." [RHEA:42708]	InterPro
NV2t015160001.1	molecular_function	GO:0016423	tRNA (guanine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [GOC:go-curators]	OMA
NV2t015161001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t015161001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t015166001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t015166001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t015167001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015171001.1	cellular_component	GO:0045177	apical part of cell	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t015174002.1	biological_process	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	InterPro
NV2t015174002.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t015174002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015175001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t015175001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t015175001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015175001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t015175001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t015177001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t015177001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t015177001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015177001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t015182001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t015182001.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t015182001.1	cellular_component	GO:0045177	apical part of cell	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]	OMA
NV2t015182001.1	cellular_component	GO:0045177	apical part of cell	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t015184001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t015184001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t015185001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t015185001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015185001.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t015185001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015185001.1	cellular_component	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t015185001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015185001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015185001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t015186001.1	biological_process	GO:0032488	Cdc42 protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478]	PANTHER
NV2t015186001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015186001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015187001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015187001.1	biological_process	GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle	"Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t015187001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015191001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015193001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	PANTHER
NV2t015193001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015193001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015193001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015193002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015193002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015195001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015197001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015198001.1	biological_process	GO:0009972	cytidine deamination	"The removal of amino group in the presence of water." [GOC:sm]	InterPro
NV2t015198001.1	biological_process	GO:0009972	cytidine deamination	"The removal of amino group in the presence of water." [GOC:sm]	PANTHER
NV2t015198001.1	biological_process	GO:0042454	ribonucleoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl]	OMA
NV2t015198001.1	biological_process	GO:0072527	pyrimidine-containing compound metabolic process	"The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t015198001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015198001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t015198001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015198001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015198001.1	molecular_function	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	OMA
NV2t015198001.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	OMA
NV2t015199001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t015199001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015199001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t015199001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015200001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015202001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015204001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t015204001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015204001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t015204002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t015204002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015204002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t015204003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t015204003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015204003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t015204004.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t015204004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015204004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t015205001.1	biological_process	GO:0001654	eye development	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]	OMA
NV2t015205001.1	biological_process	GO:0050953	sensory perception of light stimulus	"The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]	InterPro
NV2t015205001.1	biological_process	GO:0050953	sensory perception of light stimulus	"The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]	OMA
NV2t015205001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t015205001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015205001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015208001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t015211001.1	molecular_function	GO:0140560	xylosyl alpha-1,3-xylosyltransferase activity	"Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains." [PMID:22117070, PMID:8982869, RHEA:22820]	PANTHER
NV2t015211002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t015211002.1	molecular_function	GO:0035252	UDP-xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [PMID:30127001]	OMA
NV2t015211002.1	molecular_function	GO:0140560	xylosyl alpha-1,3-xylosyltransferase activity	"Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains." [PMID:22117070, PMID:8982869, RHEA:22820]	PANTHER
NV2t015212001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t015212001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t015212001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015212002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t015212002.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t015212002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015212003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t015212003.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t015212003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015213001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015213001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	InterPro
NV2t015213001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t015213001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015213001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	InterPro
NV2t015213001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t015213001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t015214001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	InterPro
NV2t015214001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t015214001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t015214001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t015214001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t015214001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t015214001.1	molecular_function	GO:0004602	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]	OMA
NV2t015214001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015216001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015218001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015218001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015218001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t015218001.1	molecular_function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	OMA
NV2t015219001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015219001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t015219001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t015219001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t015219001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015224001.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t015224001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015225001.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	PANTHER
NV2t015225001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015225002.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	PANTHER
NV2t015225002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015225003.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	PANTHER
NV2t015225003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015225004.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	PANTHER
NV2t015225004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015225005.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	OMA
NV2t015225005.1	biological_process	GO:0006706	steroid catabolic process	"The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]	PANTHER
NV2t015225005.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015225005.1	molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	"Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]	OMA
NV2t015225005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015225005.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t015226001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t015226001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t015226001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t015226001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t015226002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t015227001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t015227001.1	molecular_function	GO:0016433	rRNA (adenine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators]	OMA
NV2t015227001.1	molecular_function	GO:0016433	rRNA (adenine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators]	PANTHER
NV2t015228001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t015228001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015229001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t015233001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015233002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015233002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015234001.1	biological_process	GO:0006081	cellular aldehyde metabolic process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015234001.1	biological_process	GO:0006081	cellular aldehyde metabolic process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t015234001.1	biological_process	GO:0006081	cellular aldehyde metabolic process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t015234001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015234001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	OMA
NV2t015234001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015234001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t015234002.1	biological_process	GO:0006081	cellular aldehyde metabolic process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015234002.1	biological_process	GO:0006081	cellular aldehyde metabolic process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t015234002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015234002.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t015235001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	OMA
NV2t015235001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t015235002.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t015235003.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t015235004.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t015235005.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t015236001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t015236001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t015237001.1	biological_process	GO:0006405	RNA export from nucleus	"The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t015237001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t015237001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t015237001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t015237001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t015237001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t015237001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t015237001.1	biological_process	GO:0050000	chromosome localization	"Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t015237001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015237001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t015237001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t015237001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t015237001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015237001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t015237001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t015237002.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t015238001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	InterPro
NV2t015238002.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	InterPro
NV2t015238003.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t015238003.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	InterPro
NV2t015238003.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	OMA
NV2t015238003.1	molecular_function	GO:0004864	protein phosphatase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t015239001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t015239001.1	biological_process	GO:0030030	cell projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t015239001.1	biological_process	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t015239001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t015239001.1	biological_process	GO:0098937	anterograde dendritic transport	"The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites." [ISBN:0815316194]	OMA
NV2t015239001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t015239001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t015239001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t015239001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t015239001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t015239001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t015239001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015239001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t015239001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t015239001.1	molecular_function	GO:0008574	plus-end-directed microtubule motor activity	"A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis." [GOC:vw, PMID:32842864]	OMA
NV2t015239001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t015239002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t015239002.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t015239002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t015240001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015240002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015240003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015241001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	OMA
NV2t015241001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015241001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t015242001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015242001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t015242001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t015242001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t015242001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t015242001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015242001.1	cellular_component	GO:0070776	MOZ/MORF histone acetyltransferase complex	"A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]	OMA
NV2t015242001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t015242001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	PANTHER
NV2t015243001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t015243001.1	biological_process	GO:0046579	positive regulation of Ras protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	OMA
NV2t015243001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015243001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015243001.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t015243001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015243001.1	molecular_function	GO:0008157	protein phosphatase 1 binding	"Binding to a protein phosphatase 1." [GOC:jl]	OMA
NV2t015247001.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	OMA
NV2t015247001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015247001.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t015247001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015247001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015247001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015247001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t015248001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t015249001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015249001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t015249001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t015250001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t015251001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015251001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t015251002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015251003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015258001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015259001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t015259001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t015264001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t015264001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t015268001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015268002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015270001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t015270001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015270001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015270001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015272001.1	biological_process	GO:0015868	purine ribonucleotide transport	"The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]	OMA
NV2t015272001.1	biological_process	GO:0072348	sulfur compound transport	"The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t015272001.1	biological_process	GO:0072530	purine-containing compound transmembrane transport	"The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t015272001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015272001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015272001.1	molecular_function	GO:0000295	adenine nucleotide transmembrane transporter activity	"Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other." [PMID:11566870]	OMA
NV2t015272001.1	molecular_function	GO:0005346	purine ribonucleotide transmembrane transporter activity	"Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t015272001.1	molecular_function	GO:0008514	organic anion transmembrane transporter activity	"Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t015272001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t015272001.1	molecular_function	GO:0015294	solute:monoatomic cation symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai]	OMA
NV2t015272001.1	molecular_function	GO:0042887	amide transmembrane transporter activity	"Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]	OMA
NV2t015272001.1	molecular_function	GO:1901682	sulfur compound transmembrane transporter activity	"Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t015273001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015273001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015278001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t015283001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t015285001.1	biological_process	GO:0070898	RNA polymerase III preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on a tRNA gene through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC), (which includes BDP1, BRF1, TBP, TFIIIC in human). The PIC engages RNA polymerase III on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH, PMID:11387215, PMID:12381659]	PANTHER
NV2t015289001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015289002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015297001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t015297001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015301001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t015302001.1	biological_process	GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	"The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967, PMID:17328678, PMID:18272355, PMID:19531363, PMID:21187438]	OMA
NV2t015302001.1	biological_process	GO:0006862	nucleotide transport	"The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732]	OMA
NV2t015302001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t015302001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t015302001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t015302001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	PANTHER
NV2t015302001.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t015302001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t015302001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t015302002.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	PANTHER
NV2t015302004.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	PANTHER
NV2t015303001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t015303001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015303002.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t015303002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015304001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015304001.1	cellular_component	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	PANTHER
NV2t015304001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015306001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t015306001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015308001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015308001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015308001.1	cellular_component	GO:0071144	heteromeric SMAD protein complex	"A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020]	PANTHER
NV2t015308001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015317001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015318001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015318002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015319001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015320001.1	biological_process	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	InterPro
NV2t015320001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015329001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015329001.1	biological_process	GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle	"Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t015329001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015330001.1	biological_process	GO:0032488	Cdc42 protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478]	PANTHER
NV2t015330001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015330001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015330002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015330002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015330003.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t015330003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015333001.1	biological_process	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	PANTHER
NV2t015335001.1	biological_process	GO:0071894	obsolete histone H2B conserved C-terminal lysine ubiquitination	"OBSOLETE. A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals." [GOC:mah, GOC:vw]	PANTHER
NV2t015335002.1	biological_process	GO:0071894	obsolete histone H2B conserved C-terminal lysine ubiquitination	"OBSOLETE. A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals." [GOC:mah, GOC:vw]	PANTHER
NV2t015335003.1	biological_process	GO:0071894	obsolete histone H2B conserved C-terminal lysine ubiquitination	"OBSOLETE. A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals." [GOC:mah, GOC:vw]	PANTHER
NV2t015336001.1	biological_process	GO:0070179	D-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [CHEBI:16523, GOC:jsg, GOC:mah]	PANTHER
NV2t015336002.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t015336002.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t015336002.1	biological_process	GO:0009070	serine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t015336002.1	biological_process	GO:0070179	D-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [CHEBI:16523, GOC:jsg, GOC:mah]	PANTHER
NV2t015336002.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t015336002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t015336002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015336002.1	molecular_function	GO:0016840	carbon-nitrogen lyase activity	"Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]	OMA
NV2t015336002.1	molecular_function	GO:0016854	racemase and epimerase activity	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732]	OMA
NV2t015336002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t015336003.1	biological_process	GO:0070179	D-serine biosynthetic process	"The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [CHEBI:16523, GOC:jsg, GOC:mah]	PANTHER
NV2t015337001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	InterPro
NV2t015337001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t015340001.1	biological_process	GO:0000056	ribosomal small subunit export from nucleus	"The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t015340001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	InterPro
NV2t015340001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t015340001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t015340001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015340001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015340001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t015340002.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	InterPro
NV2t015340002.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t015346001.1	biological_process	GO:0071894	obsolete histone H2B conserved C-terminal lysine ubiquitination	"OBSOLETE. A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, and K120 in mammals." [GOC:mah, GOC:vw]	PANTHER
NV2t015348001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t015350001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015350001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t015350001.1	molecular_function	GO:0008324	monoatomic cation transmembrane transporter activity	"Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015350002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015350002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t015350003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015350003.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t015350004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015350004.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t015351001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015351001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t015351001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t015353001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t015353001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t015353001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t015355001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t015355001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t015355001.1	biological_process	GO:0051764	actin crosslink formation	"The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai]	OMA
NV2t015355001.1	biological_process	GO:0061351	neural precursor cell proliferation	"The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf]	OMA
NV2t015355001.1	biological_process	GO:1904825	protein localization to microtubule plus-end	"A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:24039245]	PANTHER
NV2t015355001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t015355001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t015355001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t015355001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015355001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t015355001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t015355001.1	molecular_function	GO:0008093	cytoskeletal anchor activity	"The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238]	OMA
NV2t015355001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t015355002.1	biological_process	GO:1904825	protein localization to microtubule plus-end	"A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:24039245]	PANTHER
NV2t015355002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015355002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t015360001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t015360001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015362001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015362001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t015362001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015362001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015363001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t015363001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t015363001.1	cellular_component	GO:0097196	Shu complex	"A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p." [GOC:jh, PMID:15654096, PMID:19496932]	PANTHER
NV2t015363001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015363001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015366001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t015366001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015366001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015366001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015370001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t015370001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t015370002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t015371001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t015382001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015382001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015382001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t015382001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t015383001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	PANTHER
NV2t015383001.1	molecular_function	GO:0004499	N,N-dimethylaniline monooxygenase activity	"Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [RHEA:24468]	InterPro
NV2t015383001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t015383001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t015383001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t015383001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t015383001.1	molecular_function	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]	OMA
NV2t015384001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t015384001.1	molecular_function	GO:0050277	sedoheptulokinase activity	"Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate." [EC:2.7.1.14, RHEA:23844]	InterPro
NV2t015384001.1	molecular_function	GO:0050277	sedoheptulokinase activity	"Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate." [EC:2.7.1.14, RHEA:23844]	PANTHER
NV2t015385001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015385001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t015385001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t015385001.1	molecular_function	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	"Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t015386001.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t015386001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	OMA
NV2t015386001.1	biological_process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw]	InterPro
NV2t015386001.1	biological_process	GO:2000780	negative regulation of double-strand break repair	"Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t015386002.1	biological_process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw]	InterPro
NV2t015387001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015387001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t015387001.1	biological_process	GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle	"Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t015387001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t015387001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015387001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015388001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t015388001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t015390001.1	biological_process	GO:0001514	selenocysteine incorporation	"The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022]	OMA
NV2t015390001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015390001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t015390001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t015390001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015390001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015391001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t015394001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015394001.1	biological_process	GO:1901888	regulation of cell junction assembly	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	PANTHER
NV2t015394001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015394001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t015394002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015394002.1	biological_process	GO:1901888	regulation of cell junction assembly	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	PANTHER
NV2t015394002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015394002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t015394003.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t015394003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015394003.1	biological_process	GO:0006939	smooth muscle contraction	"A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]	OMA
NV2t015394003.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t015394003.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t015394003.1	biological_process	GO:0010825	positive regulation of centrosome duplication	"Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]	OMA
NV2t015394003.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t015394003.1	biological_process	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	OMA
NV2t015394003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t015394003.1	biological_process	GO:0030866	cortical actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:pf]	OMA
NV2t015394003.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015394003.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	OMA
NV2t015394003.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t015394003.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t015394003.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t015394003.1	biological_process	GO:1901888	regulation of cell junction assembly	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t015394003.1	biological_process	GO:1901888	regulation of cell junction assembly	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	PANTHER
NV2t015394003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015394003.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t015394003.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t015394003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015394003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015394003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t015394003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t015395001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t015395001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t015395001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t015395001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t015395001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015395001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t015395001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t015402001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t015402001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t015402001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	InterPro
NV2t015402001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t015403001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015404001.1	biological_process	GO:0010738	regulation of protein kinase A signaling	"Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t015404001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t015404001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015404001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015404001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015404001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015404001.1	molecular_function	GO:0034237	protein kinase A regulatory subunit binding	"Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah]	OMA
NV2t015406001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015406001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015406001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015406002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015406002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015406002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015406003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015406003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015406003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015407001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015407001.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	PANTHER
NV2t015407001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015407002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015407002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t015407002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t015407002.1	biological_process	GO:0032147	activation of protein kinase activity	"Any process that initiates the activity of an inactive protein kinase." [GOC:mah]	OMA
NV2t015407002.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	PANTHER
NV2t015407002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t015407002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015407002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015407003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015407003.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	PANTHER
NV2t015407003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015408001.1	biological_process	GO:0006020	inositol metabolic process	"The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684]	OMA
NV2t015408001.1	biological_process	GO:0044275	obsolete cellular carbohydrate catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t015408001.1	biological_process	GO:0046174	polyol catabolic process	"The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators]	OMA
NV2t015408001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015408001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t015408001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t015408001.1	molecular_function	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah]	OMA
NV2t015408001.1	molecular_function	GO:0050113	inositol oxygenase activity	"Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+." [RHEA:23696]	InterPro
NV2t015409001.1	biological_process	GO:0006775	fat-soluble vitamin metabolic process	"The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]	OMA
NV2t015409001.1	biological_process	GO:0006805	xenobiotic metabolic process	"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc]	OMA
NV2t015409001.1	biological_process	GO:0007599	hemostasis	"The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732]	OMA
NV2t015409001.1	biological_process	GO:0017187	peptidyl-glutamic acid carboxylation	"The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]	OMA
NV2t015409001.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t015409001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t015409001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t015409001.1	biological_process	GO:0050817	coagulation	"The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732]	OMA
NV2t015409001.1	biological_process	GO:1901661	quinone metabolic process	"The chemical reactions and pathways involving quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie]	OMA
NV2t015409001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t015409001.1	molecular_function	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	"Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t015409001.1	molecular_function	GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity	"Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues." [RHEA:57744]	InterPro
NV2t015410001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015413001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t015413001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015413001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015417001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015417002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t015417002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015417002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417003.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417003.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015417004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015417004.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417004.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015417005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015417005.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417005.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417006.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417006.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015417007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015417007.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417007.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417008.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015417008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015417008.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417008.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417008.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417008.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417009.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015417009.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015417009.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417009.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417009.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417009.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417010.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015417010.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015417010.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015417010.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417010.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417010.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015417011.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t015417011.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015417011.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015418001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t015419001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015419001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t015419002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015419002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t015423001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015423001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t015423001.1	molecular_function	GO:0000340	RNA 7-methylguanosine cap binding	"Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]	OMA
NV2t015423001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	InterPro
NV2t015423001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t015424001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015424001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t015424002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015425001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t015425001.1	molecular_function	GO:0098599	palmitoyl hydrolase activity	"Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate." [GOC:dos, GOC:pg]	InterPro
NV2t015427001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t015427001.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	PANTHER
NV2t015429001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015429001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t015429001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t015434001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015434001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t015434001.1	biological_process	GO:0050775	positive regulation of dendrite morphogenesis	"Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]	OMA
NV2t015434001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t015434001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t015434001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t015434001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t015434001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015434001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015435001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t015435001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t015435001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t015435001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t015435001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t015435001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t015435001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t015435001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t015435001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t015435001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t015436001.1	biological_process	GO:0016266	O-glycan processing	"The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130]	OMA
NV2t015436001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t015436001.1	molecular_function	GO:0035252	UDP-xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [PMID:30127001]	OMA
NV2t015436001.1	molecular_function	GO:0035252	UDP-xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [PMID:30127001]	PANTHER
NV2t015438001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	PANTHER
NV2t015440001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	PANTHER
NV2t015440001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015440001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015440001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015441001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015441001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015441002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015441003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015441005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015441006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015442001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015442001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t015442001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t015442001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t015442001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t015442001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t015443001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015443001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015443001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015443001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015444001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t015446001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015448001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015448001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015448001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t015448001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t015448001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015448002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015448002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t015448002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015449001.1	biological_process	GO:0003382	epithelial cell morphogenesis	"The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t015449001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t015449001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t015449001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t015449001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	OMA
NV2t015449001.1	biological_process	GO:0061951	establishment of protein localization to plasma membrane	"The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw]	OMA
NV2t015449001.1	biological_process	GO:1901214	obsolete regulation of neuron death	"OBSOLETE. Any process that modulates the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t015449001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t015449001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015449001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t015449001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015449001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t015449002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t015449002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015452001.1	biological_process	GO:0090251	protein localization involved in establishment of planar polarity	"Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t015452001.1	biological_process	GO:0090251	protein localization involved in establishment of planar polarity	"Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t015452001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015452001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t015452001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015453001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t015453001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t015453001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t015453001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t015454001.1	biological_process	GO:0007274	neuromuscular synaptic transmission	"The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]	PANTHER
NV2t015454001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015457001.1	biological_process	GO:0007274	neuromuscular synaptic transmission	"The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]	PANTHER
NV2t015458001.1	biological_process	GO:0007274	neuromuscular synaptic transmission	"The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]	PANTHER
NV2t015458001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t015458001.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	OMA
NV2t015467001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015467001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t015467001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015467001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015467001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t015467001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015467002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015467002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t015467002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015467002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468001.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468002.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468003.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468003.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468004.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468004.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468005.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468005.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468006.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468006.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468007.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468007.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468008.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468008.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468009.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468009.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468010.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468010.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468011.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468012.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015468012.1	biological_process	GO:1903361	protein localization to basolateral plasma membrane	"Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351]	PANTHER
NV2t015468012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015468013.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015470001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015470001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015470001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015473001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015476001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t015476001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t015476001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015476001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t015478001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015478001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015478001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015478001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015481001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015481001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015481001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015481001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015483001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t015483002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t015484001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t015484001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t015484001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t015484001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t015484001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t015484001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015484001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t015484001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t015484001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015484001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t015485001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t015485001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t015485001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t015486001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t015486001.1	biological_process	GO:2000779	regulation of double-strand break repair	"Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF]	PANTHER
NV2t015486001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015486002.1	biological_process	GO:2000779	regulation of double-strand break repair	"Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF]	PANTHER
NV2t015488001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t015488001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015488001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015488002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015488002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015488003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015488003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015490001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t015490001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t015490001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t015490001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015490001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015490001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t015490002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015490003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015490004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015492001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015492001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t015492001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015492002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015492002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t015492002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t015492002.1	molecular_function	GO:0004707	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	OMA
NV2t015492002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015492002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015492003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015492003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t015499001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t015499001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t015499001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t015500001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015500002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015501001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t015502001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t015502001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t015503001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t015503001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t015508001.1	biological_process	GO:0000266	mitochondrial fission	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]	OMA
NV2t015508001.1	biological_process	GO:0009060	aerobic respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]	OMA
NV2t015508001.1	biological_process	GO:0009060	aerobic respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]	PANTHER
NV2t015508001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t015508002.1	biological_process	GO:0009060	aerobic respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]	PANTHER
NV2t015509002.1	biological_process	GO:0048312	intracellular distribution of mitochondria	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]	OMA
NV2t015509002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t015509002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015509002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t015510001.1	biological_process	GO:0030100	regulation of endocytosis	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]	OMA
NV2t015510001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	OMA
NV2t015510001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	PANTHER
NV2t015510001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t015510001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t015510001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t015510002.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	PANTHER
NV2t015510002.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t015510003.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	PANTHER
NV2t015510003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t015511001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	OMA
NV2t015511001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	PANTHER
NV2t015511001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t015511001.1	molecular_function	GO:0016878	acid-thiol ligase activity	"Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1.-, GOC:mah]	OMA
NV2t015512001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015512001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015512001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015512001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015512001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015513001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015513002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015513003.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t015513003.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015513003.1	biological_process	GO:0034329	cell junction assembly	"A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]	OMA
NV2t015513003.1	biological_process	GO:0042953	lipoprotein transport	"The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]	OMA
NV2t015513003.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t015513003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t015513003.1	biological_process	GO:1901896	positive regulation of ATPase-coupled calcium transmembrane transporter activity	"Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]	OMA
NV2t015513003.1	biological_process	GO:1990456	mitochondrion-endoplasmic reticulum membrane tethering	"The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:19556461, PMID:27875684]	OMA
NV2t015513003.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t015513003.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t015513003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015513003.1	molecular_function	GO:0017128	phospholipid scramblase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]	OMA
NV2t015514002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t015514002.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t015514002.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t015514002.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t015514002.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t015514002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015514002.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	InterPro
NV2t015514002.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	OMA
NV2t015514003.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t015514003.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	InterPro
NV2t015514004.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t015514004.1	molecular_function	GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	"Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH." [RHEA:20345]	InterPro
NV2t015514005.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t015516001.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015516001.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t015516001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015516001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t015516002.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015516002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015516003.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015516003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015516004.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015516004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015516005.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015516005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015516006.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015516006.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015516007.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015516007.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015517001.1	biological_process	GO:0009185	ribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t015517001.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015517001.1	biological_process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]	OMA
NV2t015517001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t015517001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t015517001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015517001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015517001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t015517001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t015517001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015517001.1	molecular_function	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	"Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t015517001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t015517002.1	biological_process	GO:0009263	deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t015517002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015518001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t015519001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t015519001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t015519001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t015519002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t015519002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015519002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t015519002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t015522001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015524001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t015526001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015526001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015527001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t015527001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	PANTHER
NV2t015527001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t015527001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015528001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t015528001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	InterPro
NV2t015528001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	OMA
NV2t015528001.1	cellular_component	GO:0000940	outer kinetochore	"The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]	OMA
NV2t015528001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t015528001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t015529002.1	molecular_function	GO:0047134	protein-disulfide reductase (NAD(P)H) activity	"Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]	PANTHER
NV2t015529003.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t015529003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015529003.1	molecular_function	GO:0047134	protein-disulfide reductase (NAD(P)H) activity	"Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]	OMA
NV2t015529003.1	molecular_function	GO:0047134	protein-disulfide reductase (NAD(P)H) activity	"Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]	PANTHER
NV2t015532001.1	biological_process	GO:0006307	DNA alkylation repair	"The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases." [PMID:10946226, PMID:35543797]	OMA
NV2t015532001.1	biological_process	GO:0035511	obsolete oxidative DNA demethylation	"OBSOLETE. Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698]	OMA
NV2t015532001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t015532001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t015532001.1	molecular_function	GO:0035516	broad specificity oxidative DNA demethylase activity	"Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA." [PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499, RHEA:30299]	OMA
NV2t015532001.1	molecular_function	GO:0051747	cytosine C-5 DNA demethylase activity	"Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851]	PANTHER
NV2t015533001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015533001.1	biological_process	GO:0098656	monoatomic anion transmembrane transport	"The process in which a monoatomic anion is transported across a membrane. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	OMA
NV2t015533001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015533001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015533001.1	molecular_function	GO:0005343	organic acid:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1]	OMA
NV2t015533001.1	molecular_function	GO:0015137	citrate transmembrane transporter activity	"Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other." [GOC:ai, RHEA:33183]	OMA
NV2t015533001.1	molecular_function	GO:0015141	succinate transmembrane transporter activity	"Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t015533002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015533002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015534001.1	biological_process	GO:0008643	carbohydrate transport	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]	OMA
NV2t015534001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015534001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t015535001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015535001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015535001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015535001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015535001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015540001.1	molecular_function	GO:0004089	carbonate dehydratase activity	"Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O." [EC:4.2.1.1]	OMA
NV2t015540001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015540001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015541001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t015541001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015541002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t015541002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015542001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t015542001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t015542002.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t015542002.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t015543001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015545001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015545001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t015546001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015546001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015546001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t015547001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t015547001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t015547001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t015547001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t015547001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t015547001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015547001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t015547002.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t015547002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015547003.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t015547003.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t015547003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015547004.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t015547004.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015548001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	PANTHER
NV2t015557001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	InterPro
NV2t015557001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t015557001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015557002.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	InterPro
NV2t015557002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015560001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	InterPro
NV2t015560001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015560002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015563001.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	InterPro
NV2t015563001.1	biological_process	GO:0033387	putrescine biosynthetic process from ornithine	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]	PANTHER
NV2t015563001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t015563002.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	InterPro
NV2t015563002.1	biological_process	GO:0033387	putrescine biosynthetic process from ornithine	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]	PANTHER
NV2t015563002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t015563003.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	InterPro
NV2t015563003.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	OMA
NV2t015563003.1	biological_process	GO:0033387	putrescine biosynthetic process from ornithine	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]	PANTHER
NV2t015563003.1	biological_process	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	OMA
NV2t015563003.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t015563003.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t015563003.1	biological_process	GO:1901605	alpha-amino acid metabolic process	"The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t015563003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015563003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t015563003.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t015563003.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t015563004.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	InterPro
NV2t015563004.1	biological_process	GO:0033387	putrescine biosynthetic process from ornithine	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]	PANTHER
NV2t015563004.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t015563005.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	InterPro
NV2t015563005.1	biological_process	GO:0033387	putrescine biosynthetic process from ornithine	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]	PANTHER
NV2t015563005.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t015565001.1	biological_process	GO:0006084	acetyl-CoA metabolic process	"The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]	OMA
NV2t015565001.1	biological_process	GO:0006554	lysine catabolic process	"The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]	OMA
NV2t015565001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t015565001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015565001.1	molecular_function	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t015565001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t015565001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t015566001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t015566001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t015566001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t015566001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015566001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t015567002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t015567002.1	biological_process	GO:0007033	vacuole organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]	OMA
NV2t015567002.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t015567002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t015567002.1	biological_process	GO:0033059	cellular pigmentation	"The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07]	OMA
NV2t015567002.1	biological_process	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	OMA
NV2t015567002.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t015567002.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t015567002.1	cellular_component	GO:0030897	HOPS complex	"A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]	OMA
NV2t015567002.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	OMA
NV2t015567002.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t015567002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015568001.1	biological_process	GO:0051180	vitamin transport	"The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t015568001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	OMA
NV2t015568001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t015568001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t015568001.1	molecular_function	GO:0031419	cobalamin binding	"Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]	InterPro
NV2t015568001.1	molecular_function	GO:0046906	tetrapyrrole binding	"Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [GOC:curators, ISBN:0198506732]	OMA
NV2t015569001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t015570001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015570001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t015570001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015570001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t015570001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015570001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015570001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t015570001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015570001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015570001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015570002.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t015571001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t015571001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t015571001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t015571001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t015571001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t015573001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015573002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015575001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015575001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015575002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015577001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t015577001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015577001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015577001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015577002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t015577002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015577002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015577003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t015577003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015577003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015577003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015577004.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t015577004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015577004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015577004.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015581001.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	PANTHER
NV2t015581001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t015582001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015582001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015582001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t015587001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015588001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t015592001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t015592001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t015592001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015593001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t015593001.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	OMA
NV2t015593001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015593001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t015593001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t015593001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015593001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t015593001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t015596001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t015596001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015596001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015596001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t015599001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t015599001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t015599001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015599001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t015600001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t015600001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t015600001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t015600001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t015600001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t015600001.1	biological_process	GO:0042256	cytosolic ribosome assembly	"The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol." [GOC:ma, PMID:30467428]	InterPro
NV2t015600001.1	biological_process	GO:0042256	cytosolic ribosome assembly	"The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol." [GOC:ma, PMID:30467428]	OMA
NV2t015600001.1	biological_process	GO:0048534	hematopoietic or lymphoid organ development	"The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149]	OMA
NV2t015600001.1	biological_process	GO:0060326	cell chemotaxis	"The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]	OMA
NV2t015600001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t015600001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t015600001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015600001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t015600001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t015600001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t015603001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t015603001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t015603001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t015603001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t015603001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t015603001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t015603001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t015603001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t015603001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t015606001.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t015606001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015606001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015607001.1	cellular_component	GO:0032221	Rpd3S complex	"A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151]	PANTHER
NV2t015607001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t015609001.1	biological_process	GO:0006549	isoleucine metabolic process	"The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	OMA
NV2t015609001.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t015609001.1	biological_process	GO:0009068	aspartate family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t015609001.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t015609001.1	biological_process	GO:1901607	alpha-amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t015609001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015609001.1	molecular_function	GO:0016840	carbon-nitrogen lyase activity	"Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]	OMA
NV2t015609001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t015611001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t015611001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t015611001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015611001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t015612001.1	biological_process	GO:0007286	spermatid development	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]	OMA
NV2t015612001.1	biological_process	GO:0015918	sterol transport	"The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]	OMA
NV2t015612001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015612001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015612001.1	cellular_component	GO:0097038	perinuclear endoplasmic reticulum	"The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]	OMA
NV2t015612001.1	cellular_component	GO:0097038	perinuclear endoplasmic reticulum	"The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]	PANTHER
NV2t015612001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t015612001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t015612001.1	molecular_function	GO:0015485	cholesterol binding	"Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]	OMA
NV2t015614001.1	biological_process	GO:0036503	ERAD pathway	"The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]	PANTHER
NV2t015614001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015615001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t015615001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015616001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015619002.1	molecular_function	GO:0043035	chromatin insulator sequence binding	"Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]	PANTHER
NV2t015623001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015623001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t015623003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015624001.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	PANTHER
NV2t015626001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t015626001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015626001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015626001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015626001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t015627001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015632001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t015632001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015632001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015632001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015632001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t015634001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015636001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t015636001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t015636001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	InterPro
NV2t015636001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t015636001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t015636001.1	biological_process	GO:0072666	establishment of protein localization to vacuole	"The directed movement of a protein to a specific location in a vacuole." [GOC:mah]	OMA
NV2t015636001.1	cellular_component	GO:0000813	ESCRT I complex	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]	OMA
NV2t015636001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015636001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t015636001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	PANTHER
NV2t015637001.1	biological_process	GO:0042138	meiotic DNA double-strand break formation	"The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]	InterPro
NV2t015637001.1	biological_process	GO:0042138	meiotic DNA double-strand break formation	"The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]	PANTHER
NV2t015637001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	InterPro
NV2t015638001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t015638001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t015638001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015638001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t015639001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t015639001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t015639001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t015639001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t015639001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t015639001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015641001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t015641002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641013.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641014.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641015.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641016.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641017.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015641020.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015642001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t015642001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015643001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t015643001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015644001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t015644001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015646001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015647001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t015647001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t015647001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t015647001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t015648001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t015648001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015655001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015655001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015655001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015655001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015655001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015655001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t015655001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t015659001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t015659001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015664001.1	biological_process	GO:0002090	regulation of receptor internalization	"Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]	OMA
NV2t015664001.1	biological_process	GO:0048261	negative regulation of receptor-mediated endocytosis	"Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators]	OMA
NV2t015664001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015664001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015664001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t015664001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015664001.1	molecular_function	GO:0140036	ubiquitin-modified protein reader activity	"A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way." [PMID:26060076]	OMA
NV2t015665001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t015665001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t015665001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t015665001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t015665001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015665001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t015665001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t015666001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t015666001.1	cellular_component	GO:0005882	intermediate filament	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]	OMA
NV2t015666001.1	cellular_component	GO:0045095	keratin filament	"A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363]	PANTHER
NV2t015668001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t015668001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015668002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015668002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015669001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t015669002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015669002.1	molecular_function	GO:0004089	carbonate dehydratase activity	"Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O." [EC:4.2.1.1]	OMA
NV2t015669002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015669002.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t015669003.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t015669004.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t015669005.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t015669006.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t015671001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t015671001.1	biological_process	GO:0071479	cellular response to ionizing radiation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]	PANTHER
NV2t015671001.1	cellular_component	GO:0030896	checkpoint clamp complex	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]	InterPro
NV2t015671001.1	cellular_component	GO:0030896	checkpoint clamp complex	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]	OMA
NV2t015672001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t015672001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t015672002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t015672003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t015684001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t015684001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t015684002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t015684002.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t015684003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t015684003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t015684003.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	OMA
NV2t015684003.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t015684003.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t015684003.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t015685001.1	biological_process	GO:0006541	glutamine metabolic process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	OMA
NV2t015685001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t015685001.1	biological_process	GO:0019217	regulation of fatty acid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]	OMA
NV2t015685001.1	biological_process	GO:0031324	negative regulation of cellular metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t015685001.1	biological_process	GO:0034983	peptidyl-lysine deacetylation	"The removal of an acetyl group from an acetylated lysine residue in a peptide or protein." [GOC:BHF, GOC:mah]	OMA
NV2t015685001.1	biological_process	GO:0045833	negative regulation of lipid metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]	OMA
NV2t015685001.1	biological_process	GO:0046676	negative regulation of insulin secretion	"Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai]	OMA
NV2t015685001.1	biological_process	GO:0046889	positive regulation of lipid biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	OMA
NV2t015685001.1	biological_process	GO:0051341	regulation of oxidoreductase activity	"Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:ai]	OMA
NV2t015685001.1	biological_process	GO:0072350	tricarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [GOC:mah]	OMA
NV2t015685001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t015685001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	PANTHER
NV2t015685001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t015685001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t015685001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t015685001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t015685001.1	molecular_function	GO:0034979	NAD-dependent protein lysine deacetylase activity	"Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide." [GOC:BHF, GOC:mah, RHEA:43636]	OMA
NV2t015685001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t015685001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t015686001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	OMA
NV2t015686001.1	biological_process	GO:0006556	S-adenosylmethionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t015686001.1	biological_process	GO:0040031	snRNA modification	"The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl]	OMA
NV2t015686001.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t015686001.1	biological_process	GO:0061157	mRNA destabilization	"Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh]	OMA
NV2t015686001.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	PANTHER
NV2t015686001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015686001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015686001.1	molecular_function	GO:0001734	mRNA m(6)A methyltransferase activity	"Catalysis of the reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H+ + S-adenosyl-L-homocysteine. This activity is the methylation of adenines in mRNA with the consensus sequence RRACH, where R is a purine, and H is C, A, or U." [EC:2.1.1.348, GOC:hjd]	OMA
NV2t015686001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t015686001.1	molecular_function	GO:0008988	rRNA (adenine-N6-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [RHEA:58728]	OMA
NV2t015686001.1	molecular_function	GO:0017070	U6 snRNA binding	"Binding to a U6 small nuclear RNA (U6 snRNA)." [GOC:mah]	OMA
NV2t015686001.1	molecular_function	GO:0035613	RNA stem-loop binding	"Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]	OMA
NV2t015686001.1	molecular_function	GO:0106346	snRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule." [PMID:27573892]	OMA
NV2t015691001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t015691001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t015691001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t015691001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t015691001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t015691001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015691001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015691001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015691001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t015691001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t015691002.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t015696001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t015696001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t015696001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015696001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015696001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t015697001.1	biological_process	GO:0018193	peptidyl-amino acid modification	"The alteration of an amino acid residue in a peptide." [GOC:mah]	InterPro
NV2t015697001.1	biological_process	GO:0018193	peptidyl-amino acid modification	"The alteration of an amino acid residue in a peptide." [GOC:mah]	OMA
NV2t015697001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015698001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t015698001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t015698001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t015715001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t015715001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t015716001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t015716001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t015718001.1	biological_process	GO:0006650	glycerophospholipid metabolic process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t015718001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t015718001.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t015718001.1	biological_process	GO:0046503	glycerolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t015718001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t015718001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	OMA
NV2t015718001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t015718001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t015719001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t015719001.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t015719001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t015719001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t015721001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t015721001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t015721001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t015721002.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t015721002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t015721002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t015721003.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t015721003.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t015721003.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t015722001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015722001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015724001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t015724001.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t015724001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t015724001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t015724002.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t015724002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t015726001.1	biological_process	GO:0006576	biogenic amine metabolic process	"The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]	OMA
NV2t015726001.1	biological_process	GO:0006650	glycerophospholipid metabolic process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t015726001.1	biological_process	GO:0034308	primary alcohol metabolic process	"The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]	OMA
NV2t015726001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t015726001.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t015726001.1	biological_process	GO:0046503	glycerolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t015726001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t015726001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	OMA
NV2t015726001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t015726001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t015728001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t015728001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015730001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t015730001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t015730001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t015731001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t015731001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t015731001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t015731001.1	biological_process	GO:0097428	protein maturation by iron-sulfur cluster transfer	"The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]	InterPro
NV2t015731001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015731001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015731001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t015731001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015731001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t015736001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t015741001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	InterPro
NV2t015741001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	OMA
NV2t015741001.1	biological_process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t015741001.1	biological_process	GO:0140673	transcription elongation-coupled chromatin remodeling	"A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation." [PMID:22922743, PMID:28053344]	InterPro
NV2t015741001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015741001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t015741001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015743001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743002.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743003.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743004.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743005.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743006.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743007.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743008.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743009.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743010.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743011.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015743012.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t015745001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t015745002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t015745002.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t015745002.1	biological_process	GO:0044770	cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle]	OMA
NV2t015745002.1	biological_process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	"Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb]	OMA
NV2t015745002.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t015745002.1	biological_process	GO:0071383	cellular response to steroid hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah]	OMA
NV2t015745002.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t015745002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015745002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015745002.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t015745002.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t015745002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t015745002.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t015750001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015750001.1	molecular_function	GO:0001609	G protein-coupled adenosine receptor activity	"Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]	OMA
NV2t015750001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t015756001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015756001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015766001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t015766001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t015775001.1	molecular_function	GO:0015616	DNA translocase activity	"Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis." [GOC:mah, PMID:16428451, PMID:17631491]	PANTHER
NV2t015775001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t015776001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t015776001.1	biological_process	GO:0043486	obsolete histone exchange	"OBSOLETE. The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]	PANTHER
NV2t015776001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t015776001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t015776001.1	biological_process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	"Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]	OMA
NV2t015776001.1	cellular_component	GO:0000118	histone deacetylase complex	"A protein complex that possesses histone deacetylase activity." [GOC:mah]	OMA
NV2t015776001.1	cellular_component	GO:0000228	nuclear chromosome	"A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah]	OMA
NV2t015776001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t015776001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t015776001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t015776001.1	cellular_component	GO:0097346	INO80-type complex	"A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820]	OMA
NV2t015776001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t015776001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015776001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015776001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t015776001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t015779001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t015779001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	OMA
NV2t015779001.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	PANTHER
NV2t015779001.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t015779001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t015779001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015779001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015779001.1	molecular_function	GO:0004523	RNA-DNA hybrid ribonuclease activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	InterPro
NV2t015779001.1	molecular_function	GO:0004523	RNA-DNA hybrid ribonuclease activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	OMA
NV2t015781001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t015781001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t015781001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t015781001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t015781001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t015785001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t015785001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t015785001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t015785001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t015785001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t015785001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t015785001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t015786001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t015790001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015790001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t015790001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015790001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t015790001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015791001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t015791001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t015791001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t015794001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015794001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015794001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015794001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015794002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015794002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015794002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015794003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015794003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015794003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015795001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015795001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t015795001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015795001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015795001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015795002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015795002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015795002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015796001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t015799001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015799001.1	cellular_component	GO:0000137	Golgi cis cisterna	"The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]	OMA
NV2t015799001.1	cellular_component	GO:0005801	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	OMA
NV2t015799001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t015801001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015801001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t015801001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	PANTHER
NV2t015801001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t015802001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t015802001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t015802001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t015802001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	PANTHER
NV2t015802001.1	biological_process	GO:0051153	regulation of striated muscle cell differentiation	"Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]	OMA
NV2t015802001.1	biological_process	GO:0060284	regulation of cell development	"Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]	OMA
NV2t015802001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015803001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t015803001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t015803001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t015805001.1	biological_process	GO:0001667	ameboidal-type cell migration	"Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]	OMA
NV2t015805001.1	biological_process	GO:0001952	regulation of cell-matrix adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]	OMA
NV2t015805001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t015805001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t015805001.1	biological_process	GO:0007162	negative regulation of cell adhesion	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]	OMA
NV2t015805001.1	biological_process	GO:0010633	negative regulation of epithelial cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t015805001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t015805001.1	biological_process	GO:0045184	establishment of protein localization	"The directed movement of a protein to a specific location." [GOC:bf]	OMA
NV2t015805001.1	biological_process	GO:0048285	organelle fission	"The creation of two or more organelles by division of one organelle." [GOC:jid]	OMA
NV2t015805001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t015805001.1	biological_process	GO:0048762	mesenchymal cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid]	OMA
NV2t015805001.1	biological_process	GO:0048863	stem cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]	OMA
NV2t015805001.1	biological_process	GO:0090148	membrane fission	"A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t015805001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t015805001.1	biological_process	GO:0097750	endosome membrane tubulation	"A membrane tubulation process occurring in an endosome membrane." [GOC:bc, GOC:PARL, PMID:26911690]	OMA
NV2t015805001.1	biological_process	GO:1900024	regulation of substrate adhesion-dependent cell spreading	"Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf]	OMA
NV2t015805001.1	biological_process	GO:1901889	negative regulation of cell junction assembly	"Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t015805001.1	biological_process	GO:2000394	positive regulation of lamellipodium morphogenesis	"Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah]	OMA
NV2t015805001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t015805001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t015805001.1	cellular_component	GO:0016328	lateral plasma membrane	"The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]	OMA
NV2t015805001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t015805001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t015805001.1	cellular_component	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	OMA
NV2t015805001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t015805001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015805001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t015805001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t015806001.1	biological_process	GO:0006650	glycerophospholipid metabolic process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t015806001.1	biological_process	GO:0007029	endoplasmic reticulum organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015806001.1	biological_process	GO:0030149	sphingolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t015806001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t015806001.1	biological_process	GO:0046503	glycerolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t015806001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t015806001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	OMA
NV2t015806001.1	cellular_component	GO:0005640	nuclear outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684]	OMA
NV2t015806001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t015806001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t015806001.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t015806001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t015806001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t015806001.1	molecular_function	GO:0050290	sphingomyelin phosphodiesterase D activity	"Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+." [EC:3.1.4.41, RHEA:20984]	InterPro
NV2t015806001.1	molecular_function	GO:0050290	sphingomyelin phosphodiesterase D activity	"Catalysis of the reaction: H2O + sphingomyelin = ceramide 1-phosphate + choline + H+." [EC:3.1.4.41, RHEA:20984]	PANTHER
NV2t015808001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t015808001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t015810001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015810001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015811001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t015811001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015811002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t015811002.1	biological_process	GO:0034067	protein localization to Golgi apparatus	"A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]	OMA
NV2t015811002.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	OMA
NV2t015811002.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t015811002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t015811002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015811002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t015811002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015811002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t015812001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015812001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015812001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015812001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015812001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015812001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015813001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015813001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015813001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015814001.1	biological_process	GO:0000055	ribosomal large subunit export from nucleus	"The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t015814001.1	biological_process	GO:0000056	ribosomal small subunit export from nucleus	"The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t015814001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t015814001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t015814001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t015814001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t015814001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015814001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015814001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t015814001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t015816001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t015816001.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t015816001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	PANTHER
NV2t015816001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015816001.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t015816001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t015816001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t015819001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t015819001.1	biological_process	GO:0030155	regulation of cell adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]	OMA
NV2t015819001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t015819001.1	biological_process	GO:0045995	regulation of embryonic development	"Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]	OMA
NV2t015819001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t015820001.1	biological_process	GO:1902275	regulation of chromatin organization	"Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879]	OMA
NV2t015820001.1	biological_process	GO:1902275	regulation of chromatin organization	"Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879]	PANTHER
NV2t015820001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t015820001.1	cellular_component	GO:0035101	FACT complex	"A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage." [PMID:12934006, PMID:12934007, PMID:16678108, PMID:34731638]	OMA
NV2t015820001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015820001.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	OMA
NV2t015820001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t015822001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	PANTHER
NV2t015822001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015824001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t015824001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t015824001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t015824001.1	biological_process	GO:0007062	sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194]	OMA
NV2t015824001.1	biological_process	GO:0007080	mitotic metaphase chromosome alignment	"A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [ISBN:0815316194]	OMA
NV2t015824001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t015824001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t015824001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t015824001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t015824001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015824001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t015824001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015824001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t015824001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t015824001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t015824001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t015827001.1	biological_process	GO:0009452	7-methylguanosine RNA capping	"The sequence of enzymatic reactions by which the RNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:vw, PMID:9266685]	InterPro
NV2t015827001.1	molecular_function	GO:0071164	RNA cap trimethylguanosine synthase activity	"Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine." [PMID:11983179, PMID:18775984]	PANTHER
NV2t015829001.1	biological_process	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	OMA
NV2t015829001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015829001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015830001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015830001.1	molecular_function	GO:0015616	DNA translocase activity	"Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis." [GOC:mah, PMID:16428451, PMID:17631491]	PANTHER
NV2t015830001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t015830002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015830002.1	molecular_function	GO:0015616	DNA translocase activity	"Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis." [GOC:mah, PMID:16428451, PMID:17631491]	PANTHER
NV2t015830002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t015832001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t015832001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t015832002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t015833001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015833001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015833001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015834001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015834001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015834001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015837001.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t015837001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015837001.1	molecular_function	GO:0016176	superoxide-generating NADPH oxidase activator activity	"Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai]	InterPro
NV2t015837001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t015838001.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t015838001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015838002.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t015838002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015838003.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t015838003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015838004.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t015838004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015838005.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t015838005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015839001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015840001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015840002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015840003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015842001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t015842001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t015842001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t015842001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015842001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t015843001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	PANTHER
NV2t015844001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t015844001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015844002.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t015844002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015844002.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t015844002.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015848001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t015848001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015850001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t015850001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t015850001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t015850001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	PANTHER
NV2t015850001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t015850001.1	biological_process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	"Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]	OMA
NV2t015850001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t015850001.1	cellular_component	GO:0031391	Elg1 RFC-like complex	"A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842, PMID:23499004, PMID:27664980]	OMA
NV2t015850001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t015850001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015850001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015850001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015850001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015850001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t015850001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t015852001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t015852001.1	biological_process	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t015852001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t015852001.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t015852001.1	biological_process	GO:1904294	positive regulation of ERAD pathway	"Any process that activates or increases the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]	InterPro
NV2t015852001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t015857001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015857001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t015857002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015857002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t015857003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015857003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t015857003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t015857003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015857003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015857003.1	molecular_function	GO:0004707	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	OMA
NV2t015857003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015857003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015857005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015857005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015858001.1	biological_process	GO:0031110	regulation of microtubule polymerization or depolymerization	"Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	InterPro
NV2t015858001.1	biological_process	GO:0031110	regulation of microtubule polymerization or depolymerization	"Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	OMA
NV2t015858001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t015860001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t015860001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t015860001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t015860001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t015860001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t015860001.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t015860001.1	biological_process	GO:0033044	regulation of chromosome organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]	OMA
NV2t015860001.1	biological_process	GO:0044087	regulation of cellular component biogenesis	"Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t015860001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	OMA
NV2t015860001.1	biological_process	GO:0051129	negative regulation of cellular component organization	"Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t015860001.1	biological_process	GO:1904430	negative regulation of t-circle formation	"Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284]	PANTHER
NV2t015860001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015860001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015860001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	InterPro
NV2t015860001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t015860001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015860001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015860001.1	molecular_function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	InterPro
NV2t015860001.1	molecular_function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	OMA
NV2t015860001.1	molecular_function	GO:0070182	DNA polymerase binding	"Binding to a DNA polymerase." [GOC:BHF, GOC:mah]	OMA
NV2t015862001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015862002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t015862002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015862003.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t015862003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015862004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015863001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015863001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015863002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015863002.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t015863002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015863003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015863003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t015865002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t015869001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t015869001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015869001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015869001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t015869002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t015869002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015870001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t015870001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	OMA
NV2t015870001.1	molecular_function	GO:0004601	peroxidase activity	"Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O." [GOC:curators]	PANTHER
NV2t015870001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015870001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t015874001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015874001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015874001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015874001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015876001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t015876001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015876001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t015876001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t015876001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	PANTHER
NV2t015877001.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t015878001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t015878001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t015878001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t015878002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t015881001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t015881001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t015881001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t015881001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	OMA
NV2t015881001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	PANTHER
NV2t015882002.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t015882002.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t015882002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t015882002.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	OMA
NV2t015882002.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	PANTHER
NV2t015883001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015884001.1	biological_process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t015884001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t015884001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t015884001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t015884001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t015884001.1	cellular_component	GO:0042788	obsolete polysomal ribosome	"OBSOLETE. A ribosome bound to mRNA that forms part of a polysome." [GOC:jl]	PANTHER
NV2t015884001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t015884001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015884001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t015884001.1	molecular_function	GO:0101005	deubiquitinase activity	"An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:mec, PMID:30783221]	OMA
NV2t015885001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015885001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t015885001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t015885001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015885001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015885001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015886001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015886001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t015886001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t015886001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015886001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015886001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015887002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015887002.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t015887002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t015887002.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t015887002.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t015887002.1	cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]	OMA
NV2t015887002.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t015887002.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t015887002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015887002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015887002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015887003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015887003.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t015887003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015887003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015887004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015887004.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t015887004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015887004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015887005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015887005.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t015887005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015887005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015887006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t015887006.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	PANTHER
NV2t015887006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015887006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015888001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t015888002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t015889001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015889001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015890001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t015890002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t015891001.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t015891001.1	biological_process	GO:0009070	serine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t015891001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t015891001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	PANTHER
NV2t015891001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t015891001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015891001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t015891001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t015891001.1	molecular_function	GO:0036424	L-phosphoserine phosphatase activity	"Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid." [PMID:25037224, PMID:9188776, RHEA:21208]	InterPro
NV2t015892001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t015892002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t015892002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t015892002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t015892002.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t015893001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015893001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015893001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015893002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015893002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015893002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015893003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015893003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015893003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t015893003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t015893003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t015895001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t015895001.1	biological_process	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	OMA
NV2t015895001.1	biological_process	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	OMA
NV2t015895001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t015895001.1	biological_process	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t015895001.1	biological_process	GO:0051353	positive regulation of oxidoreductase activity	"Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]	OMA
NV2t015895001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t015895001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015895001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015895001.1	molecular_function	GO:0003958	NADPH-hemoprotein reductase activity	"Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4]	InterPro
NV2t015895001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015895001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t015895001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	InterPro
NV2t015895001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t015895001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015895001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t015895001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t015895001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t015896001.1	biological_process	GO:0043043	peptide biosynthetic process	"The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl]	OMA
NV2t015896001.1	biological_process	GO:0044550	secondary metabolite biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]	OMA
NV2t015896001.1	biological_process	GO:0046688	response to copper ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai]	OMA
NV2t015896001.1	biological_process	GO:0046938	phytochelatin biosynthetic process	"The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732]	InterPro
NV2t015896001.1	biological_process	GO:0098849	cellular detoxification of cadmium ion	"Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw]	OMA
NV2t015896001.1	biological_process	GO:0098849	cellular detoxification of cadmium ion	"Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw]	PANTHER
NV2t015896001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t015896001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t015898001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t015898001.1	biological_process	GO:0000266	mitochondrial fission	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]	OMA
NV2t015898001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t015898001.1	biological_process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]	OMA
NV2t015898001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t015898001.1	biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]	OMA
NV2t015898001.1	biological_process	GO:0007006	mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t015898001.1	biological_process	GO:0010637	negative regulation of mitochondrial fusion	"Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]	OMA
NV2t015898001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t015898001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t015898001.1	biological_process	GO:0030308	negative regulation of cell growth	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t015898001.1	biological_process	GO:0031648	protein destabilization	"Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]	OMA
NV2t015898001.1	biological_process	GO:0033233	regulation of protein sumoylation	"Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah]	OMA
NV2t015898001.1	biological_process	GO:0043330	response to exogenous dsRNA	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators]	OMA
NV2t015898001.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t015898001.1	biological_process	GO:0050691	regulation of defense response to virus by host	"Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph]	OMA
NV2t015898001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t015898001.1	biological_process	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t015898001.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t015898001.1	biological_process	GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t015898001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t015898001.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t015898001.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t015898001.1	biological_process	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	"Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t015898001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t015898001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t015898001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t015898001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t015898001.1	molecular_function	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	OMA
NV2t015898001.1	molecular_function	GO:0019789	SUMO transferase activity	"Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250]	OMA
NV2t015898001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t015898001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t015898001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t015900001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015900001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015905001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t015905001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	InterPro
NV2t015905001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	OMA
NV2t015905001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t015905001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t015905001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t015906001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	InterPro
NV2t015906001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	OMA
NV2t015907001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015907002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015908001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t015908001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t015908001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t015908001.1	biological_process	GO:0045880	positive regulation of smoothened signaling pathway	"Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t015908001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015908001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015908001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t015908001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t015908001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015908001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t015909001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t015909001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t015909001.1	biological_process	GO:0007507	heart development	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]	OMA
NV2t015909001.1	biological_process	GO:0008306	associative learning	"Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]	OMA
NV2t015909001.1	biological_process	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	OMA
NV2t015909001.1	biological_process	GO:0042063	gliogenesis	"The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]	OMA
NV2t015909001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	OMA
NV2t015909001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t015909001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t015909001.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	OMA
NV2t015909001.1	biological_process	GO:0045685	regulation of glial cell differentiation	"Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]	OMA
NV2t015909001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t015909001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t015909001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t015909001.1	biological_process	GO:0051961	negative regulation of nervous system development	"Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	OMA
NV2t015909001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t015920001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015921001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015921001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015922001.1	biological_process	GO:0006525	arginine metabolic process	"The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]	OMA
NV2t015922001.1	biological_process	GO:0006809	nitric oxide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]	InterPro
NV2t015922001.1	biological_process	GO:0007263	nitric oxide mediated signal transduction	"An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms." [GOC:jl, PMID:21549190]	OMA
NV2t015922001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t015922001.1	biological_process	GO:0009065	glutamine family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t015922001.1	biological_process	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	OMA
NV2t015922001.1	biological_process	GO:0031284	positive regulation of guanylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]	OMA
NV2t015922001.1	biological_process	GO:0032496	response to lipopolysaccharide	"Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464]	OMA
NV2t015922001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t015922001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t015922001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015922001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015922001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015922001.1	cellular_component	GO:0012506	vesicle membrane	"The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle]	OMA
NV2t015922001.1	molecular_function	GO:0004517	nitric-oxide synthase activity	"Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897]	OMA
NV2t015922001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015922001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t015922001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	InterPro
NV2t015922001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t015922001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t015922001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t015922001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t015922001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t015922001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t015923001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t015923001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015923001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015923001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t015924001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015924001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015924001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t015924001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015924001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015925001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015925001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015925001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015925002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t015925002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015925002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t015925002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015926001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015926001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t015926001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t015926001.1	biological_process	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	OMA
NV2t015926001.1	biological_process	GO:0040012	regulation of locomotion	"Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]	OMA
NV2t015926001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t015926001.1	biological_process	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	OMA
NV2t015926001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015926001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015926001.1	cellular_component	GO:0033588	elongator holoenzyme complex	"A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]	PANTHER
NV2t015926001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t015926001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t015926001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015926001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t015926001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t015926001.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t015926001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t015926001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t015927001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t015927001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015927001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015927001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t015928001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t015928001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015928001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015928001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t015932001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t015935001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	PANTHER
NV2t015935001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t015936001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015936001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015936002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t015936002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015936002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015936002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015939001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t015939001.1	cellular_component	GO:0030891	VCB complex	"A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071]	OMA
NV2t015939001.1	cellular_component	GO:0070449	elongin complex	"A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." [PMID:12676794]	InterPro
NV2t015939001.1	cellular_component	GO:0070449	elongin complex	"A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." [PMID:12676794]	OMA
NV2t015939001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015940001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t015940001.1	biological_process	GO:0071712	obsolete ER-associated misfolded protein catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [PMID:14607247, PMID:19520858]	PANTHER
NV2t015940001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t015940001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t015940001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t015941001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	PANTHER
NV2t015941001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015941002.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	PANTHER
NV2t015941002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015941003.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	PANTHER
NV2t015941003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015942001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t015942001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t015942001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t015942001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t015945001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t015945001.1	biological_process	GO:0030490	maturation of SSU-rRNA	"Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators]	InterPro
NV2t015945001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t015945001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015945001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t015945001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t015945001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t015945001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015946001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t015946001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t015947001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015947001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t015952001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t015952001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015953001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t015953001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t015953001.1	biological_process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t015953001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t015953001.1	biological_process	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t015953001.1	biological_process	GO:0050920	regulation of chemotaxis	"Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]	OMA
NV2t015953001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t015953001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t015953001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t015953001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t015953001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t015953001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	OMA
NV2t015953001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015953001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	OMA
NV2t015953001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	PANTHER
NV2t015954001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t015954001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t015955001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015955001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015955002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015955002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015955003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015955003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015955004.1	biological_process	GO:0035442	dipeptide transmembrane transport	"The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:vw]	OMA
NV2t015955004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015955004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015955004.1	biological_process	GO:0062208	positive regulation of pattern recognition receptor signaling pathway	"Any process that decreases the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]	OMA
NV2t015955004.1	biological_process	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	OMA
NV2t015955004.1	biological_process	GO:0098739	import across plasma membrane	"The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t015955004.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t015955004.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t015955004.1	molecular_function	GO:0015647	peptidoglycan transmembrane transporter activity	"Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t015955004.1	molecular_function	GO:0035673	oligopeptide transmembrane transporter activity	"Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732]	OMA
NV2t015955005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015955005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t015956001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015956001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015956001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t015958001.1	molecular_function	GO:0030729	acetoacetate-CoA ligase activity	"Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+." [EC:6.2.1.16, RHEA:16117]	InterPro
NV2t015958001.1	molecular_function	GO:0030729	acetoacetate-CoA ligase activity	"Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+." [EC:6.2.1.16, RHEA:16117]	PANTHER
NV2t015958002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t015958002.1	biological_process	GO:0032024	positive regulation of insulin secretion	"Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah]	OMA
NV2t015958002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015958002.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t015958002.1	molecular_function	GO:0016878	acid-thiol ligase activity	"Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1.-, GOC:mah]	OMA
NV2t015958002.1	molecular_function	GO:0030729	acetoacetate-CoA ligase activity	"Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+." [EC:6.2.1.16, RHEA:16117]	InterPro
NV2t015958002.1	molecular_function	GO:0030729	acetoacetate-CoA ligase activity	"Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+." [EC:6.2.1.16, RHEA:16117]	PANTHER
NV2t015959001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t015959001.1	biological_process	GO:0008652	amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732]	OMA
NV2t015959001.1	biological_process	GO:0009164	nucleoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl]	OMA
NV2t015959001.1	biological_process	GO:0033396	beta-alanine biosynthetic process via 3-ureidopropionate	"The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982]	PANTHER
NV2t015959001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t015959001.1	biological_process	GO:0072527	pyrimidine-containing compound metabolic process	"The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t015959001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t015959001.1	molecular_function	GO:0003837	beta-ureidopropionase activity	"Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]	OMA
NV2t015959001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t015959002.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t015959002.1	biological_process	GO:0033396	beta-alanine biosynthetic process via 3-ureidopropionate	"The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982]	PANTHER
NV2t015960001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015961001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015962001.1	biological_process	GO:0000055	ribosomal large subunit export from nucleus	"The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t015962001.1	biological_process	GO:0000056	ribosomal small subunit export from nucleus	"The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t015962001.1	biological_process	GO:0000070	mitotic sister chromatid segregation	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]	OMA
NV2t015962001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t015962001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t015962001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	OMA
NV2t015962001.1	biological_process	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	InterPro
NV2t015962001.1	biological_process	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t015962001.1	biological_process	GO:0009205	purine ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t015962001.1	biological_process	GO:0022414	reproductive process	"A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]	OMA
NV2t015962001.1	biological_process	GO:0032092	positive regulation of protein binding	"Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t015962001.1	biological_process	GO:0042307	positive regulation of protein import into nucleus	"Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl]	OMA
NV2t015962001.1	biological_process	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	OMA
NV2t015962001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t015962001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t015962001.1	biological_process	GO:0050658	RNA transport	"The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t015962001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t015962001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t015962001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t015962001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t015962001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t015962001.1	cellular_component	GO:0031074	nucleocytoplasmic transport complex	"Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]	OMA
NV2t015962001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t015962001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t015962001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t015962001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t015962001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t015962001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t015962001.1	molecular_function	GO:0070883	pre-miRNA binding	"Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]	OMA
NV2t015963001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t015963001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t015963001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t015963001.1	biological_process	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	"Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]	OMA
NV2t015963001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	OMA
NV2t015963001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t015963001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t015963001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t015963001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015963001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t015963001.1	cellular_component	GO:0042734	presynaptic membrane	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]	OMA
NV2t015963001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t015963001.1	cellular_component	GO:0048786	presynaptic active zone	"A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]	OMA
NV2t015963001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t015963001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t015964001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t015964001.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t015964001.1	molecular_function	GO:0050188	phosphoenolpyruvate mutase activity	"Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, RHEA:17013]	InterPro
NV2t015965001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t015965001.1	molecular_function	GO:0051019	mitogen-activated protein kinase binding	"Binding to a mitogen-activated protein kinase." [GOC:ai]	PANTHER
NV2t015971001.1	biological_process	GO:0042754	negative regulation of circadian rhythm	"Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]	OMA
NV2t015971001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015971001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015971002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015971003.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015971004.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015971006.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015972001.1	biological_process	GO:2000147	positive regulation of cell motility	"Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah]	OMA
NV2t015972001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015972001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t015972001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t015973001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t015973001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t015973001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t015973001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t015973001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t015973001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t015975001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015975001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t015975001.1	cellular_component	GO:0035097	histone methyltransferase complex	"A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]	OMA
NV2t015975001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t015978001.1	biological_process	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t015978001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t015978001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t015978001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t015978001.1	molecular_function	GO:0047617	fatty acyl-CoA hydrolase activity	"Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+." [RHEA:16781]	InterPro
NV2t015979001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015979001.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t015979002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015979002.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t015979003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t015979003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t015979003.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t015979003.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t015980001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015980001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015980001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015980002.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t015980002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t015980002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015980002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015980002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t015980002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015980002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t015980003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t015980003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t015981001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t015981001.1	biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	PANTHER
NV2t015981002.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t015981002.1	biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	PANTHER
NV2t015981003.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t015981003.1	biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	PANTHER
NV2t015981004.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t015981004.1	biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	PANTHER
NV2t015981005.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t015981005.1	biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	PANTHER
NV2t015981006.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t015981006.1	biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	PANTHER
NV2t015981007.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t015981007.1	biological_process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	"Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis]	PANTHER
NV2t015982001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t015984001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	InterPro
NV2t015984001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	OMA
NV2t015984001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	PANTHER
NV2t015984001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t015985001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t015986001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t015986001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t015986001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t015986001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t015986001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t015986001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t015986001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t015987001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015987001.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t015987002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015987002.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t015987003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015987003.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t015987004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015987004.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t015987005.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t015987005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t015987005.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t015987005.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	OMA
NV2t015987005.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t015987005.1	cellular_component	GO:0000439	transcription factor TFIIH core complex	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]	OMA
NV2t015987005.1	cellular_component	GO:0005675	transcription factor TFIIH holo complex	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]	OMA
NV2t015987005.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t015988001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t015988001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t015988001.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	OMA
NV2t015988001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t015988001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t015988001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015988001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t015988001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t015988001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t015988001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t015988001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t015988002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t015988002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t015989001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	InterPro
NV2t015989001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t015989001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	PANTHER
NV2t015990001.1	biological_process	GO:0002697	regulation of immune effector process	"Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]	OMA
NV2t015990001.1	biological_process	GO:0002920	regulation of humoral immune response	"Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add]	OMA
NV2t015990001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t015990001.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	OMA
NV2t015990001.1	biological_process	GO:0042256	cytosolic ribosome assembly	"The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol." [GOC:ma, PMID:30467428]	OMA
NV2t015990001.1	biological_process	GO:0042256	cytosolic ribosome assembly	"The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol." [GOC:ma, PMID:30467428]	PANTHER
NV2t015990001.1	biological_process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	"Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t015990001.1	biological_process	GO:1902531	regulation of intracellular signal transduction	"Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t015990001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t015990001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	InterPro
NV2t015990001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t015990001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t015990001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t015990001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t015990001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t015990001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t015991001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015991001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015991001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t015991002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015991002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015991003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015991003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t015992001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t015993001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	OMA
NV2t015993001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t015993001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t015993001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t015993001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t015993001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t015993001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t015993001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t015995001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015995001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015995001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015995001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t015995002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t015995002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t015995002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t015996001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t015996001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t015996001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t015998001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016000001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016002001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t016002001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t016005001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016005001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016005001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016005001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016007001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016007001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016007001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016007001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t016008001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016008001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016009001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016009001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016012001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t016012001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t016012001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t016012001.1	biological_process	GO:0042148	DNA strand invasion	"The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855]	PANTHER
NV2t016012001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t016012001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t016012001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t016012001.1	molecular_function	GO:0000400	four-way junction DNA binding	"Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]	OMA
NV2t016012001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t016012001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016012001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t016012001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t016012001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t016013001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	PANTHER
NV2t016013001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t016013001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t016013001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016013001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016014001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t016014001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016014001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016015001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t016015001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t016015001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t016015001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016015001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016015001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t016017001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t016017001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	PANTHER
NV2t016017001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t016018002.1	biological_process	GO:0000132	establishment of mitotic spindle orientation	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]	OMA
NV2t016018002.1	biological_process	GO:0007058	spindle assembly involved in female meiosis II	"The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]	OMA
NV2t016018002.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t016018002.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t016018002.1	biological_process	GO:0016319	mushroom body development	"The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]	OMA
NV2t016018002.1	biological_process	GO:0034454	microtubule anchoring at centrosome	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]	OMA
NV2t016018002.1	biological_process	GO:0040040	thermosensory behavior	"Behavior that is dependent upon the sensation of temperature." [GOC:ems]	OMA
NV2t016018002.1	biological_process	GO:0055059	asymmetric neuroblast division	"The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]	OMA
NV2t016018002.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t016018002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t016018002.1	cellular_component	GO:0031312	extrinsic component of organelle membrane	"The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]	OMA
NV2t016018002.1	cellular_component	GO:0045179	apical cortex	"The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]	OMA
NV2t016018002.1	cellular_component	GO:0045180	basal cortex	"The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf]	OMA
NV2t016018002.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	OMA
NV2t016018002.1	cellular_component	GO:0061689	tricellular tight junction	"An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet." [GOC:dk, GOC:dph, PMID:22520461, PMID:25822906]	OMA
NV2t016018002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016018002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016019001.1	biological_process	GO:0043401	steroid hormone mediated signaling pathway	"The series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]	OMA
NV2t016019001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016019001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016019001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t016019001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016019001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016019001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t016019001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t016019001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t016021001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t016021001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t016021001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016021001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t016021001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t016022001.1	biological_process	GO:0002682	regulation of immune system process	"Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t016022001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t016022001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t016022001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t016022001.1	biological_process	GO:0050727	regulation of inflammatory response	"Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]	OMA
NV2t016022001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t016022001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016022001.1	cellular_component	GO:0043227	membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t016022001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t016022001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t016022001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t016031001.1	biological_process	GO:0085020	protein K6-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]	PANTHER
NV2t016031001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016031002.1	biological_process	GO:0085020	protein K6-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]	PANTHER
NV2t016031002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016033001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016034001.1	biological_process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	"Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]	InterPro
NV2t016034002.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t016034002.1	biological_process	GO:0031325	positive regulation of cellular metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t016034002.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t016034002.1	biological_process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]	OMA
NV2t016034002.1	biological_process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	"Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]	InterPro
NV2t016034002.1	biological_process	GO:1901798	positive regulation of signal transduction by p53 class mediator	"Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	OMA
NV2t016034002.1	biological_process	GO:2001022	obsolete positive regulation of response to DNA damage stimulus	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]	OMA
NV2t016034002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016034002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016034002.1	cellular_component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	"A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]	OMA
NV2t016035001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016035001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016035001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016035001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016035001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016035002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016035002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016035002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016035002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016035002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016036001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016036001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016036001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016036001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016036001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t016036001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016036001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016036001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016039001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t016039001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016039001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016041001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016041002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016041003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016041004.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t016041004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016041004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016042001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016043001.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	PANTHER
NV2t016043001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016043001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016043001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t016043001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t016043002.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	PANTHER
NV2t016043002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016043002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t016043003.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	PANTHER
NV2t016043003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016043003.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t016044001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t016044001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	InterPro
NV2t016044001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t016044001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t016047001.1	biological_process	GO:0000338	protein deneddylation	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]	OMA
NV2t016047001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t016047001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t016047001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016047001.1	biological_process	GO:0046328	regulation of JNK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	OMA
NV2t016047001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t016047001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t016047001.1	biological_process	GO:1990182	exosomal secretion	"The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898]	OMA
NV2t016047001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t016047001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016047001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t016047001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	OMA
NV2t016047001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t016047001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t016047001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t016047001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016047001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016047001.1	molecular_function	GO:0019784	deNEDDylase activity	"An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated." [GOC:mah, PMID:25628956]	OMA
NV2t016047001.1	molecular_function	GO:0019784	deNEDDylase activity	"An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated." [GOC:mah, PMID:25628956]	PANTHER
NV2t016047001.1	molecular_function	GO:0101005	deubiquitinase activity	"An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:mec, PMID:30783221]	OMA
NV2t016048001.1	molecular_function	GO:1902936	phosphatidylinositol bisphosphate binding	"Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]	PANTHER
NV2t016053001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016053001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t016053001.1	biological_process	GO:0032922	circadian regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]	OMA
NV2t016053001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016053001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016053001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t016053001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t016053001.1	molecular_function	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	PANTHER
NV2t016054001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	PANTHER
NV2t016056001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t016056001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t016056001.1	biological_process	GO:0010754	negative regulation of cGMP-mediated signaling	"Any process that decreases the rate, frequency or extent of cGMP-mediated signaling." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t016056001.1	biological_process	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t016056001.1	molecular_function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate." [RHEA:14653]	OMA
NV2t016056001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016056001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t016058001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016059001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t016060001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t016061001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t016061001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t016062001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t016062001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t016062001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t016062001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t016062001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016062001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016065001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t016065001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t016065001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016065001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	InterPro
NV2t016065001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	OMA
NV2t016067001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t016067001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t016067001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t016069001.1	molecular_function	GO:0008474	palmitoyl-(protein) hydrolase activity	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]	PANTHER
NV2t016071001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016072001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t016072001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016072001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016072001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016072001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t016072001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016072001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t016074001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016074001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016074001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t016074001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016074001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016077001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016077001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016077001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016077001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016078001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016078001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016080001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016080001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016080001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016080001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016080001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016081001.1	biological_process	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	OMA
NV2t016081001.1	biological_process	GO:0043043	peptide biosynthetic process	"The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl]	OMA
NV2t016081001.1	biological_process	GO:0044550	secondary metabolite biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]	OMA
NV2t016081001.1	biological_process	GO:0046938	phytochelatin biosynthetic process	"The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732]	InterPro
NV2t016081001.1	biological_process	GO:0098849	cellular detoxification of cadmium ion	"Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw]	PANTHER
NV2t016081001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t016081001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016085001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	OMA
NV2t016085001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	PANTHER
NV2t016085001.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	InterPro
NV2t016085001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016085001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016085001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016085001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016085001.1	molecular_function	GO:0042800	histone H3K4 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein." [PMID:12086618]	OMA
NV2t016086001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016086001.1	biological_process	GO:0006898	receptor-mediated endocytosis	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]	OMA
NV2t016086001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016086001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t016086001.1	biological_process	GO:0016482	cytosolic transport	"The directed movement of substances or organelles within the cytosol." [GOC:ai]	OMA
NV2t016086001.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t016086001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t016086001.1	biological_process	GO:0032879	regulation of localization	"Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t016086001.1	biological_process	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t016086001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t016086001.1	cellular_component	GO:0030130	clathrin coat of trans-Golgi network vesicle	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]	OMA
NV2t016086001.1	cellular_component	GO:0030132	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	InterPro
NV2t016086001.1	cellular_component	GO:0030132	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	OMA
NV2t016086001.1	cellular_component	GO:0045334	clathrin-coated endocytic vesicle	"A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]	OMA
NV2t016086001.1	cellular_component	GO:0071439	clathrin complex	"A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411]	InterPro
NV2t016086001.1	cellular_component	GO:0071439	clathrin complex	"A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411]	PANTHER
NV2t016086001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t016086001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t016086001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016086001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t016087001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016087001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016087001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016087001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016088001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	OMA
NV2t016088001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t016088001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t016088001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t016088001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t016088001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t016088001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t016088001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t016088001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016089001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t016090001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016092001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t016092001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t016092001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t016092001.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	OMA
NV2t016092001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t016092001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016092001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t016092001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t016092001.1	molecular_function	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	OMA
NV2t016092002.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t016092002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016092003.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t016092003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016092004.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t016092004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016092005.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t016092005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016094001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t016094001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t016094001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t016095001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t016095001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016095001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016095001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t016096001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016096001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016096001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016096002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016096002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016096002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016096003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016096003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016096003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016096004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016096004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016096004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016097001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t016097001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	PANTHER
NV2t016097002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t016097002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	PANTHER
NV2t016097003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t016097003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t016097003.1	molecular_function	GO:0004566	beta-glucuronidase activity	"Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31]	OMA
NV2t016097003.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	PANTHER
NV2t016100001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t016100002.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t016100003.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t016101001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016101001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016101001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016103001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016103001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016103001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016103001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t016103001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t016106001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t016106001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016107001.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	PANTHER
NV2t016107001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t016109001.1	biological_process	GO:0006805	xenobiotic metabolic process	"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc]	OMA
NV2t016109001.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t016109001.1	biological_process	GO:0042572	retinol metabolic process	"The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]	OMA
NV2t016109001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t016109001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t016109001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t016109001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t016109001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t016109001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t016109001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t016109001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t016111001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t016111001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016111002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t016111002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016112001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t016112001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t016112001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t016112001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t016112001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016112001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t016112001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t016112001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016112001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016112001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016112001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016113001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t016113001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t016113001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t016113001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t016113001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t016113001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t016113001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t016114001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t016114001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t016114001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	PANTHER
NV2t016116001.1	cellular_component	GO:0005682	U5 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	InterPro
NV2t016116001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016116001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t016116001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t016116001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016116001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t016117001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t016117002.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	PANTHER
NV2t016118001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	InterPro
NV2t016118001.1	molecular_function	GO:0033204	ribonuclease P RNA binding	"Binding to RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963]	InterPro
NV2t016118002.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	InterPro
NV2t016118003.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t016118003.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t016118003.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016118003.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	InterPro
NV2t016118003.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	OMA
NV2t016118003.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t016118003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016118003.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t016118003.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t016119001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t016119001.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t016119001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t016119001.1	biological_process	GO:1901657	glycosyl compound metabolic process	"The chemical reactions and pathways involving glycosyl compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t016119001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	InterPro
NV2t016119001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t016119001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t016119001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t016119001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t016119001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t016119001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t016121001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t016121001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t016121001.1	biological_process	GO:0034620	cellular response to unfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]	OMA
NV2t016121001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t016121001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t016121001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016121001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016121001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016121001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016121001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t016121001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	OMA
NV2t016121001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t016121001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t016121001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t016122001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016122001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016123001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016124001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016127001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	PANTHER
NV2t016127001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t016127001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016127001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016127002.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	PANTHER
NV2t016127002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016127003.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	PANTHER
NV2t016127003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016128001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t016128001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016128001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016128001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t016128001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	PANTHER
NV2t016130001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t016130001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t016130001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t016130001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t016130002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t016130003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t016130003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t016130004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016132001.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	OMA
NV2t016132001.1	cellular_component	GO:0070877	microprocessor complex	"A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994]	OMA
NV2t016132001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t016132001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016132001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t016132001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t016132001.1	molecular_function	GO:0070878	primary miRNA binding	"Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding." [GOC:sl, PMID:15531877, PMID:15574589]	PANTHER
NV2t016133001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016135001.1	biological_process	GO:0006605	protein targeting	"The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]	OMA
NV2t016135001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t016135001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t016135001.1	biological_process	GO:1903232	melanosome assembly	"The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22511774]	PANTHER
NV2t016135001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t016135001.1	cellular_component	GO:0031085	BLOC-3 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248]	OMA
NV2t016135001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t016135001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t016136001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016136002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016136002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016136004.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	OMA
NV2t016136004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016136004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t016136004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016136004.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t016136004.1	molecular_function	GO:0004683	calmodulin-dependent protein kinase activity	"Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah, PMID:11264466]	OMA
NV2t016136004.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t016136004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016136004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016136005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016136005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016136006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016136007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016136007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016136008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016137001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t016137001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	PANTHER
NV2t016137001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016137001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016138001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016138001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t016138001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016138002.1	biological_process	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	OMA
NV2t016138002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016138002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t016138002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t016138002.1	biological_process	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t016138002.1	biological_process	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	OMA
NV2t016138002.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	OMA
NV2t016138002.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t016138002.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t016138002.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t016138002.1	biological_process	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t016138002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016138002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t016138002.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t016138002.1	cellular_component	GO:0036477	somatodendritic compartment	"The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]	OMA
NV2t016138002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t016138002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016138002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016138002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016138003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016138003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t016138003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016138004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016138004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t016138004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016138005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016138005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t016138005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016138006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016138006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t016138006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016141001.1	biological_process	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	"Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis]	PANTHER
NV2t016141001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016142001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t016142001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t016143002.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	PANTHER
NV2t016143003.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	PANTHER
NV2t016143005.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	PANTHER
NV2t016144001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	InterPro
NV2t016144001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	OMA
NV2t016144001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	PANTHER
NV2t016144001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t016144001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016144001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t016144001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t016144001.1	molecular_function	GO:0019781	NEDD8 activating enzyme activity	"Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924]	OMA
NV2t016144001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t016144002.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	InterPro
NV2t016144002.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	PANTHER
NV2t016144002.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t016144003.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	PANTHER
NV2t016144003.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t016144004.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	PANTHER
NV2t016144004.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t016145001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t016145001.1	biological_process	GO:0006909	phagocytosis	"A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]	OMA
NV2t016145001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t016145001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t016145001.1	biological_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	"The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]	OMA
NV2t016145001.1	biological_process	GO:0070863	positive regulation of protein exit from endoplasmic reticulum	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t016145001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	OMA
NV2t016145001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t016145001.1	biological_process	GO:2000010	positive regulation of protein localization to cell surface	"Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]	OMA
NV2t016145001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t016145001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t016145001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016145001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016147001.1	biological_process	GO:0031110	regulation of microtubule polymerization or depolymerization	"Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	InterPro
NV2t016147001.1	biological_process	GO:0031110	regulation of microtubule polymerization or depolymerization	"Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]	OMA
NV2t016147001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t016148001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016148001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t016148001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t016148001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	OMA
NV2t016148001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t016148001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t016148001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016148001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t016148001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t016148001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t016150001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t016150001.1	biological_process	GO:0071932	replication fork reversal	"Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved." [PMID:19406929]	PANTHER
NV2t016150001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t016150001.1	molecular_function	GO:0017108	5'-flap endonuclease activity	"Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]	OMA
NV2t016150001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	InterPro
NV2t016150001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t016151001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t016151001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016151001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016151001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016151001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016151001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t016151001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016151001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016153001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016155001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016155001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t016155001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t016155001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t016155001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	OMA
NV2t016155001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	PANTHER
NV2t016155001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t016155001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t016155001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t016155001.1	molecular_function	GO:0004703	G protein-coupled receptor kinase activity	"Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate." [GOC:dph]	OMA
NV2t016155001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016155001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016155002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016155002.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	PANTHER
NV2t016156001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016156001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016156001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016156001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016157001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	InterPro
NV2t016158001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016158001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016158001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016158001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016163001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016163001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016163001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016163002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016163002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016163002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016164001.1	biological_process	GO:0001708	cell fate specification	"The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate." [GOC:go_curators]	OMA
NV2t016164001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016164001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016164001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016164001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016164001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016164001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016164001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016164002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016164002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016164002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016164003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016164003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016164003.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016165001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t016165001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t016165001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t016165001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016165001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t016165001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t016165001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t016165001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t016165002.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t016165002.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t016165003.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t016165003.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t016167001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	PANTHER
NV2t016167001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016167002.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	PANTHER
NV2t016167002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016167002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016168001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t016168001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t016170001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016170002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016170002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016170002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t016170002.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t016172001.1	biological_process	GO:0042594	response to starvation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]	PANTHER
NV2t016172001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016172002.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t016172002.1	biological_process	GO:0042594	response to starvation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]	OMA
NV2t016172002.1	biological_process	GO:0042594	response to starvation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]	PANTHER
NV2t016172002.1	biological_process	GO:0044351	macropinocytosis	"An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size." [PMID:14732047]	OMA
NV2t016172002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016172002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016173001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t016175001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016175001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016175001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016175001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t016176001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016176001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016176001.1	molecular_function	GO:0015171	amino acid transmembrane transporter activity	"Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t016176001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016177001.1	biological_process	GO:2000781	positive regulation of double-strand break repair	"Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]	InterPro
NV2t016177001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016177002.1	biological_process	GO:2000781	positive regulation of double-strand break repair	"Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]	InterPro
NV2t016177002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016178001.1	biological_process	GO:0000395	mRNA 5'-splice site recognition	"Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	PANTHER
NV2t016178001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t016178001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t016178001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016180001.1	biological_process	GO:0051445	regulation of meiotic cell cycle	"Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016181001.1	biological_process	GO:0032786	positive regulation of DNA-templated transcription, elongation	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	OMA
NV2t016181001.1	biological_process	GO:0140673	transcription elongation-coupled chromatin remodeling	"A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation." [PMID:22922743, PMID:28053344]	InterPro
NV2t016181001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016181001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016182001.1	biological_process	GO:0001514	selenocysteine incorporation	"The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022]	OMA
NV2t016182001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t016182001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t016182001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t016182001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016182001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016188001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	PANTHER
NV2t016188001.1	molecular_function	GO:0004499	N,N-dimethylaniline monooxygenase activity	"Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [RHEA:24468]	InterPro
NV2t016188001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t016188001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t016188001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t016188001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t016190001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t016190001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t016190001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016190001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t016190001.1	molecular_function	GO:0015276	ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016194001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t016194001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t016194001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016194001.1	molecular_function	GO:0003884	D-amino-acid oxidase activity	"Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3]	InterPro
NV2t016194001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016194001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t016194001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t016194001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t016195001.1	biological_process	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	InterPro
NV2t016195001.1	biological_process	GO:0006913	nucleocytoplasmic transport	"The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]	OMA
NV2t016195001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t016195001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t016195001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016195001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016195001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t016197001.1	biological_process	GO:0006884	cell volume homeostasis	"Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t016197001.1	biological_process	GO:0055080	monoatomic cation homeostasis	"Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah]	OMA
NV2t016197001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016197001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t016197001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t016197001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016197001.1	molecular_function	GO:0015379	potassium:chloride symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.1.5]	OMA
NV2t016197001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016197002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016197002.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t016197002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016198001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t016198001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016198001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	OMA
NV2t016198001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t016198001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t016198001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t016198002.1	biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]	PANTHER
NV2t016198002.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t016198002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t016199001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016199002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016199002.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	InterPro
NV2t016199003.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016199004.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016199005.1	biological_process	GO:0014074	response to purine-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:ef]	OMA
NV2t016199005.1	biological_process	GO:0035590	purinergic nucleotide receptor signaling pathway	"The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:9755289]	OMA
NV2t016199005.1	biological_process	GO:0046683	response to organophosphorus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]	OMA
NV2t016199005.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016199005.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	InterPro
NV2t016199005.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t016199005.1	biological_process	GO:1902074	response to salt	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t016199005.1	cellular_component	GO:0005637	nuclear inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]	OMA
NV2t016199005.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t016199005.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t016199005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016199005.1	molecular_function	GO:0099094	ligand-gated monoatomic cation channel activity	"Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016199006.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016199006.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	InterPro
NV2t016199007.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016199008.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016199008.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	InterPro
NV2t016203001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016204001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016204001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016204001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t016204001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t016204001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t016204002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016204002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t016206001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t016206001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t016206001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t016208001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t016209001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t016209001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016209001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016209001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016210001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t016210001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016213001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016213001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016213001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016214001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016214002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016214003.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016214004.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016214005.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016214006.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016214007.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016214008.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t016216001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t016216001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t016216001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t016217001.1	biological_process	GO:1901605	alpha-amino acid metabolic process	"The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t016217001.1	molecular_function	GO:0003884	D-amino-acid oxidase activity	"Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3]	InterPro
NV2t016217001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016217001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t016217001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t016217001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t016218001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t016218001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t016218001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016219001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t016219002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t016219003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t016220001.1	biological_process	GO:0015914	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	InterPro
NV2t016220001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016220001.1	molecular_function	GO:0008525	phosphatidylcholine transporter activity	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]	OMA
NV2t016220001.1	molecular_function	GO:0008526	phosphatidylinositol transfer activity	"Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t016220001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t016220001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t016220001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016220001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016220001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t016221001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016221001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016221002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016221002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016221002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016222001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016222001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016222002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016222002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016222002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016222002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016222002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016222002.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t016223001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	InterPro
NV2t016223001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t016223001.1	biological_process	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	OMA
NV2t016223001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t016223001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t016223001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t016223001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t016225001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016225001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016226001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t016227001.1	molecular_function	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]	InterPro
NV2t016227001.1	molecular_function	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]	OMA
NV2t016229001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016229001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016230001.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	PANTHER
NV2t016230001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t016230001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t016230001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t016230001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t016230001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t016230001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t016232001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	InterPro
NV2t016232001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016232001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016232001.1	molecular_function	GO:0017070	U6 snRNA binding	"Binding to a U6 small nuclear RNA (U6 snRNA)." [GOC:mah]	InterPro
NV2t016232001.1	molecular_function	GO:0030623	U5 snRNA binding	"Binding to a U5 small nuclear RNA (U5 snRNA)." [GOC:jl]	InterPro
NV2t016232001.1	molecular_function	GO:0097157	pre-mRNA intronic binding	"Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624]	PANTHER
NV2t016236001.1	biological_process	GO:0000132	establishment of mitotic spindle orientation	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]	OMA
NV2t016236001.1	biological_process	GO:0001667	ameboidal-type cell migration	"Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]	OMA
NV2t016236001.1	biological_process	GO:0001675	acrosome assembly	"The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb]	OMA
NV2t016236001.1	biological_process	GO:0001764	neuron migration	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]	OMA
NV2t016236001.1	biological_process	GO:0007097	nuclear migration	"The directed movement of the nucleus to a specific location within a cell." [GOC:ai]	OMA
NV2t016236001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t016236001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t016236001.1	biological_process	GO:0007405	neuroblast proliferation	"The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]	OMA
NV2t016236001.1	biological_process	GO:0007423	sensory organ development	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]	OMA
NV2t016236001.1	biological_process	GO:0007611	learning or memory	"The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125]	OMA
NV2t016236001.1	biological_process	GO:0008090	retrograde axonal transport	"The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]	OMA
NV2t016236001.1	biological_process	GO:0008344	adult locomotory behavior	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]	OMA
NV2t016236001.1	biological_process	GO:0008347	glial cell migration	"The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]	OMA
NV2t016236001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t016236001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t016236001.1	biological_process	GO:0019226	transmission of nerve impulse	"The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194]	OMA
NV2t016236001.1	biological_process	GO:0021952	central nervous system projection neuron axonogenesis	"Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t016236001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016236001.1	biological_process	GO:0030855	epithelial cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]	OMA
NV2t016236001.1	biological_process	GO:0031023	microtubule organizing center organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016236001.1	biological_process	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	OMA
NV2t016236001.1	biological_process	GO:0045931	positive regulation of mitotic cell cycle	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t016236001.1	biological_process	GO:0047496	vesicle transport along microtubule	"The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl]	OMA
NV2t016236001.1	biological_process	GO:0048814	regulation of dendrite morphogenesis	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]	OMA
NV2t016236001.1	biological_process	GO:0048854	brain morphogenesis	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]	OMA
NV2t016236001.1	biological_process	GO:0050772	positive regulation of axonogenesis	"Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai]	OMA
NV2t016236001.1	biological_process	GO:0050905	neuromuscular process	"Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]	OMA
NV2t016236001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	OMA
NV2t016236001.1	biological_process	GO:0051642	centrosome localization	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t016236001.1	biological_process	GO:0051651	maintenance of location in cell	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]	OMA
NV2t016236001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	OMA
NV2t016236001.1	cellular_component	GO:0000235	astral microtubule	"Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]	OMA
NV2t016236001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t016236001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t016236001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t016236001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016236001.1	cellular_component	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	OMA
NV2t016236001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t016236001.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t016236001.1	cellular_component	GO:0031252	cell leading edge	"The area of a motile cell closest to the direction of movement." [GOC:pg]	OMA
NV2t016236001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t016236001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t016236001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t016236001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t016236001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016236001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t016236001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t016236001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	OMA
NV2t016236001.1	molecular_function	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	OMA
NV2t016236001.1	molecular_function	GO:0070840	dynein complex binding	"Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]	OMA
NV2t016236001.1	molecular_function	GO:0070840	dynein complex binding	"Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah]	PANTHER
NV2t016237001.1	biological_process	GO:0003014	renal system process	"A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]	OMA
NV2t016237001.1	biological_process	GO:0005979	regulation of glycogen biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]	OMA
NV2t016237001.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t016237001.1	biological_process	GO:0010799	regulation of peptidyl-threonine phosphorylation	"Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]	OMA
NV2t016237001.1	biological_process	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t016237001.1	biological_process	GO:0033135	regulation of peptidyl-serine phosphorylation	"Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	OMA
NV2t016237001.1	biological_process	GO:0034763	negative regulation of transmembrane transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]	OMA
NV2t016237001.1	biological_process	GO:0035305	negative regulation of dephosphorylation	"Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]	OMA
NV2t016237001.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	OMA
NV2t016237001.1	biological_process	GO:0043407	negative regulation of MAP kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t016237001.1	biological_process	GO:0043922	negative regulation by host of viral transcription	"Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:jl]	OMA
NV2t016237001.1	biological_process	GO:0045071	negative regulation of viral genome replication	"Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators]	OMA
NV2t016237001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016237001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016237001.1	biological_process	GO:0046627	negative regulation of insulin receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]	OMA
NV2t016237001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	OMA
NV2t016237001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t016237001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t016237001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	PANTHER
NV2t016237001.1	biological_process	GO:0051050	positive regulation of transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t016237001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t016237001.1	biological_process	GO:0051497	negative regulation of stress fiber assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	OMA
NV2t016237001.1	biological_process	GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t016237001.1	biological_process	GO:0051926	negative regulation of calcium ion transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t016237001.1	biological_process	GO:0070874	negative regulation of glycogen metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]	OMA
NV2t016237001.1	biological_process	GO:0071320	cellular response to cAMP	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah]	OMA
NV2t016237001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	OMA
NV2t016237001.1	biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]	OMA
NV2t016237001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t016237001.1	biological_process	GO:0090317	negative regulation of intracellular protein transport	"Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t016237001.1	biological_process	GO:0120031	plasma membrane bounded cell projection assembly	"Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t016237001.1	biological_process	GO:1905475	regulation of protein localization to membrane	"Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	OMA
NV2t016237001.1	biological_process	GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	"OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]	OMA
NV2t016237001.1	biological_process	GO:2001151	regulation of renal water transport	"Any process that modulates the frequency, rate or extent of renal water transport." [GOC:obol]	OMA
NV2t016237001.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t016237001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016237001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t016237001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t016237001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016237001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t016237001.1	cellular_component	GO:0031256	leading edge membrane	"The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]	OMA
NV2t016237001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t016237001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t016237001.1	molecular_function	GO:0004445	inositol-polyphosphate 5-phosphatase activity	"Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]	OMA
NV2t016237001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t016237001.1	molecular_function	GO:0016312	inositol bisphosphate phosphatase activity	"Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb]	OMA
NV2t016237001.1	molecular_function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]	OMA
NV2t016237001.1	molecular_function	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	"Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate." [GOC:mah]	OMA
NV2t016238003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016240001.1	cellular_component	GO:1990130	GATOR1 complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]	PANTHER
NV2t016240002.1	cellular_component	GO:1990130	GATOR1 complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]	PANTHER
NV2t016241001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016241001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t016242001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016242001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016242001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t016243001.1	biological_process	GO:0010508	positive regulation of autophagy	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t016243001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t016243001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t016243001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t016243001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t016243001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t016243001.1	cellular_component	GO:0035859	Seh1-associated complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112]	OMA
NV2t016243001.1	cellular_component	GO:1990130	GATOR1 complex	"A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]	PANTHER
NV2t016243001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t016244001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t016245001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t016246001.1	biological_process	GO:0006607	NLS-bearing protein import into nucleus	"The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai]	OMA
NV2t016246001.1	biological_process	GO:0006999	nuclear pore organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]	OMA
NV2t016246001.1	biological_process	GO:0036228	protein localization to nuclear inner membrane	"A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane." [GOC:dgf, PMID:16929305]	OMA
NV2t016246001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t016246001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t016246001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016246001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t016247001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t016247001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016247001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t016247001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t016247001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t016247002.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t016248001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016248001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016248001.1	molecular_function	GO:0015421	ABC-type oligopeptide transporter activity	"Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [RHEA:14429]	PANTHER
NV2t016248001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016248001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t016248001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t016248002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016248002.1	molecular_function	GO:0015421	ABC-type oligopeptide transporter activity	"Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [RHEA:14429]	PANTHER
NV2t016248002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016248002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t016250001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t016250001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	OMA
NV2t016250001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t016251001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t016251001.1	cellular_component	GO:0044613	nuclear pore central transport channel	"The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t016251001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016252001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t016252001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016252001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t016252001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t016252001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t016252002.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t016253001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016253001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016253001.1	molecular_function	GO:0015421	ABC-type oligopeptide transporter activity	"Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [RHEA:14429]	PANTHER
NV2t016253001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016253001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t016253001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t016254001.1	biological_process	GO:0032012	regulation of ARF protein signal transduction	"Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]	InterPro
NV2t016258001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t016258001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t016258001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t016258001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t016258001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t016259001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t016259002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t016261001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016261001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t016261001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	PANTHER
NV2t016261001.1	biological_process	GO:0007269	neurotransmitter secretion	"The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph]	OMA
NV2t016261001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t016261001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016261001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t016261001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t016261001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t016262001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t016262001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t016262001.1	biological_process	GO:0051791	medium-chain fatty acid metabolic process	"The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolisms]	OMA
NV2t016262001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016262001.1	molecular_function	GO:0004312	fatty acid synthase activity	"Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]	OMA
NV2t016262001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t016265001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016265001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016265001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016270001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t016270001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016270001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016270002.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t016270002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016270002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016273001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t016273001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016273001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016278002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t016279001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016279002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016280001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016283002.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t016283002.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	InterPro
NV2t016283002.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t016283002.1	biological_process	GO:0065004	protein-DNA complex assembly	"The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl]	OMA
NV2t016283002.1	biological_process	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	OMA
NV2t016283002.1	biological_process	GO:1902977	mitotic DNA replication preinitiation complex assembly	"Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	PANTHER
NV2t016283002.1	cellular_component	GO:0031261	DNA replication preinitiation complex	"A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184]	OMA
NV2t016283002.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t016283002.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t016283002.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t016284001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016285001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	InterPro
NV2t016285001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t016285001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t016285001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t016285001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t016285001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t016285001.1	molecular_function	GO:0050023	L-fuconate dehydratase activity	"Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O." [EC:4.2.1.68, RHEA:22772]	InterPro
NV2t016286001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016286001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016286001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016286002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016286002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016286003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016286003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016286004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016286004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016286005.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016286005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016286006.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016286006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016289001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016289001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016289001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016289002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016289002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016289002.1	biological_process	GO:0048255	mRNA stabilization	"Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid]	OMA
NV2t016289002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016289002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016289002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016289002.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t016289002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016289002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016289005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016289005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016289005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016289006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016289006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016289006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016289007.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016289007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016289007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016290001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t016290001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	PANTHER
NV2t016290001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016290001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016291001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	InterPro
NV2t016291001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t016291001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016291001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t016293001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t016293001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t016293001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016293001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016294001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016294001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t016294001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t016294001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t016294001.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t016294001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t016294001.1	biological_process	GO:0010977	negative regulation of neuron projection development	"Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t016294001.1	biological_process	GO:0016358	dendrite development	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]	OMA
NV2t016294001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t016294001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	OMA
NV2t016294001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016294001.1	biological_process	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t016294001.1	biological_process	GO:0070828	heterochromatin organization	"Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah]	OMA
NV2t016294001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016294001.1	cellular_component	GO:0016581	NuRD complex	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]	OMA
NV2t016294001.1	cellular_component	GO:0016581	NuRD complex	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]	PANTHER
NV2t016294001.1	cellular_component	GO:0035098	ESC/E(Z) complex	"A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]	OMA
NV2t016294001.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	OMA
NV2t016294001.1	cellular_component	GO:0098687	chromosomal region	"Any subdivision of a chromosome along its length." [GOC:dos]	OMA
NV2t016294001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t016294001.1	molecular_function	GO:0004407	histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [PMID:9893272, RHEA:58196]	OMA
NV2t016294001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	OMA
NV2t016295001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016295001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t016295001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t016295002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016295002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t016295003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016295003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t016296001.1	biological_process	GO:0006165	obsolete nucleoside diphosphate phosphorylation	"OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	OMA
NV2t016296001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t016296001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	OMA
NV2t016296001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t016296001.1	biological_process	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t016296001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t016296001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t016296001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t016296001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016296001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016297001.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	InterPro
NV2t016297001.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	OMA
NV2t016297001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t016297001.1	biological_process	GO:0033499	galactose catabolic process via UDP-galactose	"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821]	PANTHER
NV2t016297001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t016297001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016297001.1	molecular_function	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity	"Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7]	OMA
NV2t016297001.1	molecular_function	GO:0003978	UDP-glucose 4-epimerase activity	"Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]	OMA
NV2t016300001.1	biological_process	GO:0003400	regulation of COPII vesicle coating	"Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t016300001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t016300001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t016300001.1	cellular_component	GO:0030176	obsolete integral component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t016300001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t016300001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t016300001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016301001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t016301001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016301001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016306001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t016306002.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t016306003.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t016307001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t016307001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016308001.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	PANTHER
NV2t016308001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016308001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t016309001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t016310001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t016310002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t016310002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016311001.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	PANTHER
NV2t016311001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016311001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t016311001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t016311002.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	PANTHER
NV2t016311002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016311002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t016311003.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	PANTHER
NV2t016311003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016311003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t016311004.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	PANTHER
NV2t016311004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016311004.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t016316001.1	biological_process	GO:0097484	dendrite extension	"Long distance growth of a single dendrite involved in cellular development." [GOC:BHF, GOC:rl]	OMA
NV2t016316001.1	biological_process	GO:0097484	dendrite extension	"Long distance growth of a single dendrite involved in cellular development." [GOC:BHF, GOC:rl]	PANTHER
NV2t016316001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016316001.1	molecular_function	GO:0001099	basal RNA polymerase II transcription machinery binding	"Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH]	OMA
NV2t016317001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	PANTHER
NV2t016317002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t016317002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t016317002.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t016317002.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	PANTHER
NV2t016317002.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	OMA
NV2t016319001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016319001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016321001.1	biological_process	GO:0010529	obsolete negative regulation of transposition	"OBSOLETE. Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]	OMA
NV2t016321001.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	OMA
NV2t016321001.1	biological_process	GO:0035092	sperm DNA condensation	"The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001]	OMA
NV2t016321001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t016321001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t016321001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016321001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t016321001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t016321001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016321001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016321001.1	molecular_function	GO:0034584	piRNA binding	"Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]	OMA
NV2t016322001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016322002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016322003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016322003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t016322003.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t016322004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016322004.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t016325001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016325001.1	molecular_function	GO:0017171	serine hydrolase activity	"Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]	PANTHER
NV2t016325001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t016326001.1	biological_process	GO:1990918	double-strand break repair involved in meiotic recombination	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination." [GOC:mah, PMID:15238514]	PANTHER
NV2t016326001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016326001.1	molecular_function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	InterPro
NV2t016327001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t016327001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t016327001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t016327001.1	biological_process	GO:2000779	regulation of double-strand break repair	"Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t016327001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016327001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t016327001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016327001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016327001.1	cellular_component	GO:0030289	protein phosphatase 4 complex	"A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits." [GOC:bhm, PMID:10026142]	OMA
NV2t016327001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016327001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016327001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t016327002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016327002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016328001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t016330001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	InterPro
NV2t016330001.1	biological_process	GO:0048312	intracellular distribution of mitochondria	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]	OMA
NV2t016330001.1	biological_process	GO:0048312	intracellular distribution of mitochondria	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]	PANTHER
NV2t016330001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016330001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t016330001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016330002.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	InterPro
NV2t016330002.1	biological_process	GO:0048312	intracellular distribution of mitochondria	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]	PANTHER
NV2t016330002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016333001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t016333001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t016334001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t016334001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t016335001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t016335001.1	cellular_component	GO:0000347	THO complex	"The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]	OMA
NV2t016335001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t016337001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t016345001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t016345001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t016345002.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t016345002.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t016346001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t016346001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t016346001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t016346001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016346001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016346001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t016347001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t016347001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016348001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t016348001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016348002.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t016348002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t016348002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t016348002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016348002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016348002.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t016348003.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t016348003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016350001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t016350001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t016351001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t016351001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t016351001.1	cellular_component	GO:0070449	elongin complex	"A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." [PMID:12676794]	OMA
NV2t016351001.1	cellular_component	GO:0070449	elongin complex	"A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." [PMID:12676794]	PANTHER
NV2t016351001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t016352001.1	biological_process	GO:0007507	heart development	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]	OMA
NV2t016352001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016352001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016352001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016352001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	OMA
NV2t016352001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	PANTHER
NV2t016355001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016355001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016355001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016355001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016357001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016357001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016359001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016359001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016359001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016359001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016360001.1	biological_process	GO:0019321	pentose metabolic process	"The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t016360001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t016360001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t016360001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t016360001.1	molecular_function	GO:0008201	heparin binding	"Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t016360001.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t016360002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t016360002.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t016362001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016362001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016367001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016367001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t016367001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	PANTHER
NV2t016368001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t016368001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016368001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t016369001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t016370001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t016370001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016370001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t016371001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016371001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016371001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016373001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t016373001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t016373001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016373001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016374001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016375001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t016375001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t016375001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t016375001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t016375001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t016375001.1	molecular_function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	"Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324]	PANTHER
NV2t016377001.1	biological_process	GO:0097035	regulation of membrane lipid distribution	"Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909]	PANTHER
NV2t016377001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016377002.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016377002.1	biological_process	GO:0055091	phospholipid homeostasis	"Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t016377002.1	biological_process	GO:0071709	membrane assembly	"The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]	OMA
NV2t016377002.1	biological_process	GO:0097035	regulation of membrane lipid distribution	"Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909]	OMA
NV2t016377002.1	biological_process	GO:0097035	regulation of membrane lipid distribution	"Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909]	PANTHER
NV2t016377002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016377002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016378001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	PANTHER
NV2t016378002.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	PANTHER
NV2t016378003.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	PANTHER
NV2t016380001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t016380001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t016380001.1	biological_process	GO:0007006	mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016380001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t016380001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t016380001.1	biological_process	GO:1901537	positive regulation of DNA demethylation	"Any process that activates or increases the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]	PANTHER
NV2t016381001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t016381001.1	cellular_component	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	OMA
NV2t016381001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t016381001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t016381001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	PANTHER
NV2t016383001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t016383001.1	cellular_component	GO:0030133	transport vesicle	"Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]	OMA
NV2t016383001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t016383001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t016383001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	PANTHER
NV2t016384001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t016384001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t016384001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016384001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t016384001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t016384001.1	molecular_function	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	PANTHER
NV2t016385001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t016385001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t016385001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016385001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016385001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016386001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t016386001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016386002.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t016386002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016386002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016386003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t016386003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t016386003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t016386003.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t016386003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016386003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016386003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016387001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	InterPro
NV2t016387001.1	biological_process	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	"A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136]	OMA
NV2t016387001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t016387001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t016387001.1	molecular_function	GO:0005504	fatty acid binding	"Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]	OMA
NV2t016387001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t016387001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t016387001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t016387001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t016388001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t016388001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t016388001.1	molecular_function	GO:0004300	enoyl-CoA hydratase activity	"Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17]	OMA
NV2t016388001.1	molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	"Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]	OMA
NV2t016388001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016388001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t016389001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016389001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016391001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t016391001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t016391001.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t016391001.1	biological_process	GO:0044089	positive regulation of cellular component biogenesis	"Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]	OMA
NV2t016391001.1	biological_process	GO:0051054	positive regulation of DNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	OMA
NV2t016391001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t016391001.1	cellular_component	GO:0033557	Slx1-Slx4 complex	"A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]	InterPro
NV2t016391001.1	cellular_component	GO:0033557	Slx1-Slx4 complex	"A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]	OMA
NV2t016391001.1	cellular_component	GO:0033557	Slx1-Slx4 complex	"A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]	PANTHER
NV2t016391001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016391001.1	molecular_function	GO:0008821	crossover junction DNA endonuclease activity	"Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.21.10]	OMA
NV2t016391001.1	molecular_function	GO:0017108	5'-flap endonuclease activity	"Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]	OMA
NV2t016393001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	OMA
NV2t016393001.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t016393001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t016393001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t016393001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t016393001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016393001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016393001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t016393001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	PANTHER
NV2t016395001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t016397001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016398001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	InterPro
NV2t016398001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t016398001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t016398001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016398001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016398001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t016398001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016400001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016400001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t016402001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t016403001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016403001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t016403001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016407001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	PANTHER
NV2t016407002.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	PANTHER
NV2t016410001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	PANTHER
NV2t016416001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	PANTHER
NV2t016417001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	PANTHER
NV2t016420001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t016420001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016420001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016420001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016423001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t016423001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016423001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016423001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016426001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016426001.1	biological_process	GO:0099022	vesicle tethering	"The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion." [PMID:27243008]	OMA
NV2t016426001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t016426001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t016428001.1	biological_process	GO:0031326	regulation of cellular biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t016428001.1	biological_process	GO:0051171	obsolete regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t016428001.1	biological_process	GO:0070453	regulation of heme biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]	PANTHER
NV2t016428001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016428001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t016431001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016431001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t016432001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016432001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t016432002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016432002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t016432003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016432003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t016433001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t016433001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t016433001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t016434001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016434001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016434001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016434001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016434001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016435001.1	biological_process	GO:0006384	transcription initiation at RNA polymerase III promoter	"A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]	InterPro
NV2t016435001.1	biological_process	GO:0006384	transcription initiation at RNA polymerase III promoter	"A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]	OMA
NV2t016435001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t016435001.1	cellular_component	GO:0030880	RNA polymerase complex	"Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah]	InterPro
NV2t016435001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t016435001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t016437001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t016437001.1	biological_process	GO:0051259	protein complex oligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929]	InterPro
NV2t016437001.1	biological_process	GO:0051259	protein complex oligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929]	OMA
NV2t016437001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016437001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t016437001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t016437001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t016438001.1	biological_process	GO:0046359	butyrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid." [ISBN:0198506732]	PANTHER
NV2t016438001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t016438001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t016438001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t016439001.1	biological_process	GO:0000096	sulfur amino acid metabolic process	"The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]	OMA
NV2t016439001.1	biological_process	GO:0009069	serine family amino acid metabolic process	"The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t016439001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016439001.1	molecular_function	GO:0016783	sulfurtransferase activity	"Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544]	InterPro
NV2t016439001.1	molecular_function	GO:0016783	sulfurtransferase activity	"Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544]	OMA
NV2t016440001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t016440001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t016440001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016440001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t016440001.1	biological_process	GO:0046578	regulation of Ras protein signal transduction	"Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	OMA
NV2t016440001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t016440001.1	biological_process	GO:1903059	regulation of protein lipidation	"Any process that modulates the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]	OMA
NV2t016440001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t016440001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t016440001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016440001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016440001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t016441001.1	biological_process	GO:0000904	obsolete cell morphogenesis involved in differentiation	"OBSOLETE. The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators]	OMA
NV2t016441001.1	biological_process	GO:0001952	regulation of cell-matrix adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]	OMA
NV2t016441001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016441001.1	biological_process	GO:0007162	negative regulation of cell adhesion	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]	OMA
NV2t016441001.1	biological_process	GO:0007172	signal complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862]	InterPro
NV2t016441001.1	biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	"The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t016441001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t016441001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t016441001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t016441001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t016441001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t016441001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t016441001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t016441001.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t016441001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t016441001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t016441001.1	biological_process	GO:0048699	generation of neurons	"The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]	OMA
NV2t016441001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t016441001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t016441001.1	biological_process	GO:1901888	regulation of cell junction assembly	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t016441001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016441001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t016441001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t016441001.1	cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]	OMA
NV2t016441001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t016441001.1	cellular_component	GO:0043197	dendritic spine	"A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]	OMA
NV2t016441001.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t016441001.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t016441001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016441001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016441001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t016441001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t016441001.1	molecular_function	GO:0140677	molecular function activator activity	"A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t016442001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t016442001.1	biological_process	GO:0009306	protein secretion	"The controlled release of proteins from a cell." [GOC:ai]	OMA
NV2t016442001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t016442001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t016442001.1	biological_process	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t016442001.1	biological_process	GO:0045055	regulated exocytosis	"A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]	OMA
NV2t016442001.1	biological_process	GO:0061564	axon development	"The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr]	OMA
NV2t016442001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t016442001.1	biological_process	GO:0098876	vesicle-mediated transport to the plasma membrane	"The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos]	OMA
NV2t016442001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016442001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t016442001.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	OMA
NV2t016442001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t016442001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t016442001.1	cellular_component	GO:0098791	Golgi apparatus subcompartment	"A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus." [GOC:dos]	OMA
NV2t016442001.1	cellular_component	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t016442001.1	molecular_function	GO:0003925	G protein activity	"A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]	OMA
NV2t016442001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016442001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016442001.1	molecular_function	GO:0031489	myosin V binding	"Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]	OMA
NV2t016442002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016443001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016443001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016443001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016443001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016443001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t016443001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t016444001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	OMA
NV2t016444001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t016444001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t016444001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t016444001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t016445001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016445001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t016445001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	PANTHER
NV2t016445001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t016445001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t016447001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t016447001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t016447001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t016449001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016449001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t016449001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	PANTHER
NV2t016449001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t016449001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016449001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016451001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t016451001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016453001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t016453001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t016453001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t016453001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t016453001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t016453001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t016453001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016453001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t016453001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t016454001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016455001.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016455001.1	biological_process	GO:0035510	DNA dealkylation	"The removal of an alkyl group from one or more nucleotides within an DNA molecule." [GOC:bf]	OMA
NV2t016455001.1	biological_process	GO:0036090	cleavage furrow ingression	"Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [PMID:15811947, PMID:20687468]	OMA
NV2t016455001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t016455001.1	biological_process	GO:0070988	demethylation	"The process of removing one or more methyl groups from a molecule." [GOC:BHF, GOC:rl]	InterPro
NV2t016455001.1	biological_process	GO:1902275	regulation of chromatin organization	"Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879]	OMA
NV2t016455001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t016455001.1	cellular_component	GO:0070938	contractile ring	"A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]	OMA
NV2t016455001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t016455001.1	molecular_function	GO:0035516	broad specificity oxidative DNA demethylase activity	"Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA." [PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499, RHEA:30299]	OMA
NV2t016456001.1	biological_process	GO:0006936	muscle contraction	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]	OMA
NV2t016456001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t016456001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t016456001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t016456001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t016457001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016457001.1	molecular_function	GO:0070034	telomerase RNA binding	"Binding to the telomerase RNA template." [GOC:krc, PMID:16884717]	PANTHER
NV2t016458001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016458001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016458001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t016458001.1	molecular_function	GO:0005388	P-type calcium transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)." [RHEA:18105]	OMA
NV2t016458001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016458001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016458001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t016458002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016458002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016458002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t016458002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016458003.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016458003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016458003.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t016458003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016458004.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016458004.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t016458004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016458005.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016458005.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t016458005.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016458006.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016458006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016458006.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t016458006.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016458007.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016458007.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t016458007.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016459001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t016459001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t016459001.1	cellular_component	GO:0097526	spliceosomal tri-snRNP complex	"A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]	PANTHER
NV2t016459001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t016459001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t016459001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016461001.1	biological_process	GO:0006097	glyoxylate cycle	"A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732]	InterPro
NV2t016461001.1	biological_process	GO:0044262	obsolete cellular carbohydrate metabolic process	"OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t016461001.1	biological_process	GO:0046487	glyoxylate metabolic process	"The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]	OMA
NV2t016461001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t016461001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016461001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t016461001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016461001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016461001.1	molecular_function	GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	OMA
NV2t016462001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	InterPro
NV2t016462001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t016462001.1	biological_process	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]	OMA
NV2t016462001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016462001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016462001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t016463001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t016463001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t016463001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t016464001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t016464001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t016464001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	OMA
NV2t016466001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t016466001.1	cellular_component	GO:0097526	spliceosomal tri-snRNP complex	"A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]	PANTHER
NV2t016466001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016466002.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t016466002.1	cellular_component	GO:0097526	spliceosomal tri-snRNP complex	"A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]	PANTHER
NV2t016466002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016468001.1	biological_process	GO:0006097	glyoxylate cycle	"A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732]	InterPro
NV2t016468001.1	biological_process	GO:0044262	obsolete cellular carbohydrate metabolic process	"OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t016468001.1	biological_process	GO:0046487	glyoxylate metabolic process	"The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]	OMA
NV2t016468001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t016468001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t016468001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016468001.1	molecular_function	GO:0046912	acyltransferase activity, acyl groups converted into alkyl on transfer	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]	OMA
NV2t016469001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t016469001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t016469001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	InterPro
NV2t016469001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t016469001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016469001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t016470001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t016470001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t016470001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t016470001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	OMA
NV2t016470001.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t016470002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t016470002.1	molecular_function	GO:0019213	deacetylase activity	"Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]	PANTHER
NV2t016471001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t016471002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t016471002.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t016471002.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	OMA
NV2t016472001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t016472001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t016472001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016472001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016472001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t016472001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t016472001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t016474001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t016474001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t016476001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t016476002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t016481001.1	biological_process	GO:0000154	rRNA modification	"The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t016481001.1	biological_process	GO:0016556	mRNA modification	"The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t016481001.1	biological_process	GO:0031119	tRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]	OMA
NV2t016481001.1	biological_process	GO:0070131	positive regulation of mitochondrial translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]	OMA
NV2t016481001.1	biological_process	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	"The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]	OMA
NV2t016481001.1	biological_process	GO:0090646	mitochondrial tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw]	OMA
NV2t016481001.1	cellular_component	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	OMA
NV2t016481001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t016481001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t016481001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	PANTHER
NV2t016481001.1	molecular_function	GO:0016866	intramolecular transferase activity	"Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t016481001.1	molecular_function	GO:0070180	large ribosomal subunit rRNA binding	"Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]	OMA
NV2t016482001.1	biological_process	GO:0007129	homologous chromosome pairing at meiosis	"The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]	OMA
NV2t016482001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	InterPro
NV2t016482001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t016482001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	PANTHER
NV2t016482001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016482001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t016483001.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t016483002.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t016483003.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t016483004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016483004.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t016483005.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t016483006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016483006.1	cellular_component	GO:0038039	G protein-coupled receptor heterodimeric complex	"A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]	PANTHER
NV2t016483006.1	molecular_function	GO:0004965	G protein-coupled GABA receptor activity	"Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]	OMA
NV2t016486001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t016486001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t016486001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t016487001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016487001.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t016487001.1	biological_process	GO:0035610	protein side chain deglutamylation	"The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048]	PANTHER
NV2t016487001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t016487001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016487001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016488001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	PANTHER
NV2t016489001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t016489001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016489001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016490001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	OMA
NV2t016490001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016490001.1	biological_process	GO:0033619	membrane protein proteolysis	"The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains." [GOC:pde]	OMA
NV2t016490001.1	biological_process	GO:0036503	ERAD pathway	"The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]	OMA
NV2t016490001.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t016490001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t016490001.1	cellular_component	GO:0071556	obsolete integral component of lumenal side of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t016490001.1	cellular_component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	"The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]	OMA
NV2t016490001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t016490001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t016490001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t016490001.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	InterPro
NV2t016490001.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t016490001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t016493001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016493001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016493001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016494001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016494001.1	cellular_component	GO:0005689	U12-type spliceosomal complex	"Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]	PANTHER
NV2t016494001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016494001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016496001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t016496001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016496001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016496001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016496001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016496002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016496002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016496002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016500001.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t016500001.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	InterPro
NV2t016500001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t016500001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016500001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t016500001.1	molecular_function	GO:0070003	threonine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t016501001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016502001.1	cellular_component	GO:0031416	NatB complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]	PANTHER
NV2t016502001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016502002.1	biological_process	GO:0017196	N-terminal peptidyl-methionine acetylation	"The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]	OMA
NV2t016502002.1	cellular_component	GO:0031416	NatB complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]	OMA
NV2t016502002.1	cellular_component	GO:0031416	NatB complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]	PANTHER
NV2t016502002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t016502002.1	molecular_function	GO:0004596	peptide alpha-N-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [GOC:mah, PMID:30054468]	OMA
NV2t016502002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016502003.1	cellular_component	GO:0031416	NatB complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]	PANTHER
NV2t016502004.1	cellular_component	GO:0031416	NatB complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]	PANTHER
NV2t016502005.1	cellular_component	GO:0031416	NatB complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]	PANTHER
NV2t016503001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t016503001.1	biological_process	GO:0007007	inner mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016503001.1	biological_process	GO:0045039	protein insertion into mitochondrial inner membrane	"The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." [GOC:mcc, GOC:vw, PMID:18672008]	PANTHER
NV2t016503001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	OMA
NV2t016503001.1	biological_process	GO:0090151	establishment of protein localization to mitochondrial membrane	"The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t016503001.1	cellular_component	GO:0042719	mitochondrial intermembrane space protein transporter complex	"Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]	OMA
NV2t016508001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t016508001.1	biological_process	GO:0016598	protein arginylation	"The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]	PANTHER
NV2t016508001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t016512001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016514001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t016514001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t016514001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t016514001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t016515001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t016515001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t016515001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t016516001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t016516001.1	biological_process	GO:0007007	inner mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016516001.1	biological_process	GO:0045039	protein insertion into mitochondrial inner membrane	"The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." [GOC:mcc, GOC:vw, PMID:18672008]	PANTHER
NV2t016516001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	OMA
NV2t016516001.1	biological_process	GO:0071806	protein transmembrane transport	"The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw]	OMA
NV2t016516001.1	biological_process	GO:0090151	establishment of protein localization to mitochondrial membrane	"The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t016516001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t016516001.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t016516001.1	molecular_function	GO:0022884	macromolecule transmembrane transporter activity	"Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016516001.1	molecular_function	GO:0140318	protein transporter activity	"Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]	OMA
NV2t016518001.1	biological_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	InterPro
NV2t016518001.1	biological_process	GO:0019646	aerobic electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport]	OMA
NV2t016518001.1	biological_process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]	OMA
NV2t016518001.1	cellular_component	GO:0005746	mitochondrial respirasome	"The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]	OMA
NV2t016518001.1	cellular_component	GO:0070069	cytochrome complex	"A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah]	OMA
NV2t016518001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t016518001.1	cellular_component	GO:0098803	respiratory chain complex	"Any protein complex that is part of a respiratory chain." [GOC:dos]	OMA
NV2t016518001.1	cellular_component	GO:1902495	transmembrane transporter complex	"A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586]	OMA
NV2t016518001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t016519001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016519001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t016519001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t016519001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t016519001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t016519001.1	biological_process	GO:0070861	regulation of protein exit from endoplasmic reticulum	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t016519001.1	biological_process	GO:0090317	negative regulation of intracellular protein transport	"Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t016519001.1	cellular_component	GO:0000153	cytoplasmic ubiquitin ligase complex	"A ubiquitin ligase complex found in the cytoplasm." [GOC:mah]	OMA
NV2t016519001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t016519001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t016519001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t016519001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016519001.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t016519001.1	molecular_function	GO:1990381	ubiquitin-specific protease binding	"Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]	PANTHER
NV2t016522001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t016522001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016522001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016523001.1	biological_process	GO:0007369	gastrulation	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]	OMA
NV2t016523001.1	biological_process	GO:0031623	receptor internalization	"A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]	OMA
NV2t016523001.1	biological_process	GO:0061462	protein localization to lysosome	"A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]	OMA
NV2t016523001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	OMA
NV2t016523001.1	biological_process	GO:0072665	protein localization to vacuole	"A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd]	PANTHER
NV2t016523001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t016523001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t016523001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016523001.1	cellular_component	GO:0045334	clathrin-coated endocytic vesicle	"A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]	OMA
NV2t016523001.1	molecular_function	GO:0032050	clathrin heavy chain binding	"Binding to a clathrin heavy chain." [GOC:mah]	OMA
NV2t016523001.1	molecular_function	GO:0035612	AP-2 adaptor complex binding	"Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499]	OMA
NV2t016523001.1	molecular_function	GO:0140318	protein transporter activity	"Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]	OMA
NV2t016526001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t016527001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016527001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t016527001.1	biological_process	GO:1904659	glucose transmembrane transport	"The process in which glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050]	PANTHER
NV2t016527001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016527001.1	molecular_function	GO:0005355	glucose transmembrane transporter activity	"Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016527001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t016527001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016529001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t016530001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016530002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016530003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016530004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016530005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016532001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016533001.1	biological_process	GO:0006269	DNA replication, synthesis of primer	"The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718]	InterPro
NV2t016533001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	PANTHER
NV2t016533002.1	biological_process	GO:0006269	DNA replication, synthesis of primer	"The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718]	InterPro
NV2t016533002.1	biological_process	GO:0006269	DNA replication, synthesis of primer	"The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [PMID:11395402, PMID:38203225, PMID:38492718]	OMA
NV2t016533002.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t016533002.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	PANTHER
NV2t016533002.1	cellular_component	GO:0005658	alpha DNA polymerase:primase complex	"A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377]	OMA
NV2t016533002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016537001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016539001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016540001.1	cellular_component	GO:0030915	Smc5-Smc6 complex	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]	InterPro
NV2t016540001.1	cellular_component	GO:0030915	Smc5-Smc6 complex	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]	PANTHER
NV2t016540002.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t016540002.1	biological_process	GO:0006301	postreplication repair	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh]	OMA
NV2t016540002.1	cellular_component	GO:0000793	condensed chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]	OMA
NV2t016540002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016540002.1	cellular_component	GO:0030915	Smc5-Smc6 complex	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]	InterPro
NV2t016540002.1	cellular_component	GO:0030915	Smc5-Smc6 complex	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]	PANTHER
NV2t016540002.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t016540002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016540002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t016541001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t016541001.1	biological_process	GO:0035308	negative regulation of protein dephosphorylation	"Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	OMA
NV2t016541001.1	biological_process	GO:0035308	negative regulation of protein dephosphorylation	"Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	PANTHER
NV2t016541001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t016541001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t016541001.1	molecular_function	GO:0004865	protein serine/threonine phosphatase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb]	OMA
NV2t016541001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016541001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016543001.1	biological_process	GO:0031167	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	InterPro
NV2t016543001.1	biological_process	GO:0031167	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	PANTHER
NV2t016543001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t016543001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t016543001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016543001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t016543001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t016543001.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	OMA
NV2t016543001.1	molecular_function	GO:0062105	RNA 2'-O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide." [PMID:30626973, RHEA:58956]	OMA
NV2t016546001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t016546001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t016546002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016546002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016546002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016546003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016546003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016547001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016547001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016547001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016547002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016547002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016547003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016547003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016547004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016547004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016550001.1	molecular_function	GO:0061733	peptide-lysine-N-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide." [GOC:dph, RHEA:45948]	PANTHER
NV2t016552002.1	molecular_function	GO:0070005	cysteine-type aminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016552003.1	molecular_function	GO:0070005	cysteine-type aminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016555001.1	biological_process	GO:0000380	alternative mRNA splicing, via spliceosome	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]	OMA
NV2t016555001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t016556001.1	cellular_component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	"An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]	PANTHER
NV2t016556001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016556002.1	cellular_component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	"An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]	PANTHER
NV2t016556002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016556003.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t016556003.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t016556003.1	cellular_component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	"An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]	PANTHER
NV2t016556003.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t016556003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016557001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016557001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t016557001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016565001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016565001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016565001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016565001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016566001.1	biological_process	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	OMA
NV2t016566001.1	biological_process	GO:0042542	response to hydrogen peroxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]	OMA
NV2t016566001.1	biological_process	GO:0070301	cellular response to hydrogen peroxide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah]	PANTHER
NV2t016572001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016572001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016572001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016572001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016572001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016572002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016572002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016572002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016572002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016572002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016572003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016572003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016572003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016572003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016572003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016574001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016574001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016574001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016574001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016574001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016579001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t016579001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016579001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016579001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016580001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016580001.1	molecular_function	GO:0022832	voltage-gated channel activity	"Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016580002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016580002.1	molecular_function	GO:0022832	voltage-gated channel activity	"Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016580003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016580003.1	molecular_function	GO:0022832	voltage-gated channel activity	"Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016580004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016580004.1	molecular_function	GO:0022832	voltage-gated channel activity	"Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016580005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016580005.1	molecular_function	GO:0022832	voltage-gated channel activity	"Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016580006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016580006.1	molecular_function	GO:0022832	voltage-gated channel activity	"Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016580007.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016580007.1	molecular_function	GO:0022832	voltage-gated channel activity	"Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016583001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t016583001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016583001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016583001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t016584001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016584001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016586001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016587001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	PANTHER
NV2t016588001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t016590001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t016590001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t016590001.1	cellular_component	GO:0035658	Mon1-Ccz1 complex	"A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862]	InterPro
NV2t016590001.1	cellular_component	GO:0035658	Mon1-Ccz1 complex	"A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862]	OMA
NV2t016593001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t016593001.1	biological_process	GO:0016079	synaptic vesicle exocytosis	"Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg]	OMA
NV2t016593001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016593001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016593002.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t016593002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016593003.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t016593003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016595001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t016595001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t016595001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t016595001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t016595001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t016595001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t016595001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t016595001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t016596001.1	biological_process	GO:0043966	obsolete histone H3 acetylation	"OBSOLETE. The modification of histone H3 by the addition of an acetyl group." [GOC:jl]	PANTHER
NV2t016596001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t016597001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t016597001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016598001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t016598001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t016598002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t016599001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016599001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t016599001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016599001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016599001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t016599001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t016599001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t016599001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t016599001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t016601001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t016601001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t016602001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t016602001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t016602001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	OMA
NV2t016602001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	InterPro
NV2t016602001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t016602001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t016604001.1	molecular_function	GO:0008817	corrinoid adenosyltransferase activity	"Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin." [PMID:19933577, PMID:5946606]	PANTHER
NV2t016605001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016605001.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	PANTHER
NV2t016605002.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	PANTHER
NV2t016606001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t016606001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t016606001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016606001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016608001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016608001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t016610001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t016610001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016610002.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t016610002.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	OMA
NV2t016610002.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	OMA
NV2t016610002.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t016610002.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t016610002.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t016610002.1	cellular_component	GO:0031105	septin complex	"A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632]	OMA
NV2t016610002.1	cellular_component	GO:0032153	cell division site	"The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]	OMA
NV2t016610002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t016610002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016610002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016610002.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t016611001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016611001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016611001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t016611001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t016611001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t016613001.1	biological_process	GO:0006308	DNA catabolic process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t016613001.1	biological_process	GO:0006308	DNA catabolic process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t016613001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016613003.1	biological_process	GO:0006308	DNA catabolic process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t016613003.1	biological_process	GO:0006308	DNA catabolic process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t016613003.1	biological_process	GO:0006308	DNA catabolic process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t016613003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016613003.1	molecular_function	GO:0004536	DNA nuclease activity	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]	OMA
NV2t016614001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016614001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016614001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016616001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t016616001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016616001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016616001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t016616001.1	molecular_function	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	"Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38]	PANTHER
NV2t016617001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	InterPro
NV2t016619001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t016619001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t016619002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t016620001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t016620001.1	cellular_component	GO:0071006	U2-type catalytic step 1 spliceosome	"A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t016620002.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t016620002.1	biological_process	GO:0000245	spliceosomal complex assembly	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]	OMA
NV2t016620002.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t016620002.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t016620002.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t016620002.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t016620002.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t016620002.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t016620002.1	cellular_component	GO:0000974	Prp19 complex	"A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]	OMA
NV2t016620002.1	cellular_component	GO:0005662	DNA replication factor A complex	"A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]	OMA
NV2t016620002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016620002.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t016620002.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t016620002.1	cellular_component	GO:0071006	U2-type catalytic step 1 spliceosome	"A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t016620002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t016620002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t016620002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016620002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t016620002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t016620003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t016620003.1	cellular_component	GO:0071006	U2-type catalytic step 1 spliceosome	"A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t016620004.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t016620004.1	cellular_component	GO:0071006	U2-type catalytic step 1 spliceosome	"A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t016620004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016622001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t016622001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016622001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016623001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016623001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016623001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016623001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016624001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016624001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016624001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	PANTHER
NV2t016624002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t016624002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016624002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016624002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016624002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	PANTHER
NV2t016624002.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	InterPro
NV2t016624002.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	OMA
NV2t016624003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016624003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016624003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	PANTHER
NV2t016625001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t016625001.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t016625001.1	biological_process	GO:0051171	obsolete regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t016625001.1	biological_process	GO:0062012	regulation of small molecule metabolic process	"Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t016625001.1	biological_process	GO:0106064	regulation of cobalamin metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [PMID:29056341]	PANTHER
NV2t016625001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t016625001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016625001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t016625002.1	biological_process	GO:0106064	regulation of cobalamin metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [PMID:29056341]	PANTHER
NV2t016625002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016626001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t016626001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016626001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016626001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t016627001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t016627001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t016627001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t016627001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016627001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t016627001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t016630001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016632001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016632001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t016634001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016634001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016634001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t016634001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016634001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016636001.1	biological_process	GO:0031016	pancreas development	"The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones." [GOC:cvs]	InterPro
NV2t016636001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016636001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016637001.1	biological_process	GO:0006572	tyrosine catabolic process	"The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]	OMA
NV2t016637001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t016637001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t016637001.1	molecular_function	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah]	InterPro
NV2t016637001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t016637001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016637001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016640001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016640001.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t016643001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t016643001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t016643001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t016643001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016643001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016643001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t016643001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t016643001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016643001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016643001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016643001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t016644001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	OMA
NV2t016644001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t016644001.1	biological_process	GO:0042435	indole-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl]	OMA
NV2t016644001.1	biological_process	GO:0042446	hormone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t016644001.1	biological_process	GO:0043604	amide biosynthetic process	"The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]	OMA
NV2t016644001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t016644001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t016644001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t016644001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t016648001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016648001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016649001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t016649001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t016649001.1	biological_process	GO:0010639	negative regulation of organelle organization	"Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	OMA
NV2t016649001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t016649001.1	biological_process	GO:0062028	regulation of stress granule assembly	"Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778]	OMA
NV2t016649001.1	biological_process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t016649001.1	biological_process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t016649001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016649001.1	molecular_function	GO:0004864	protein phosphatase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t016649001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t016649001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t016649001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t016650001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016650002.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	OMA
NV2t016650002.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	OMA
NV2t016650002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016650002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t016653001.1	biological_process	GO:0006760	folic acid-containing compound metabolic process	"The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah]	InterPro
NV2t016653001.1	biological_process	GO:0006760	folic acid-containing compound metabolic process	"The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah]	OMA
NV2t016653001.1	biological_process	GO:0009396	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	InterPro
NV2t016653001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t016653001.1	biological_process	GO:0042559	pteridine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]	OMA
NV2t016653001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t016653001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t016653001.1	molecular_function	GO:0016832	aldehyde-lyase activity	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators]	OMA
NV2t016655001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016655001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t016655001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t016655001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t016655001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016655001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016656001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t016656001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	InterPro
NV2t016656001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016656001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t016656001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t016656001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t016656001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016656001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016656001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t016656001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t016656001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t016658001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t016658001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016659001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t016659001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016659001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016659001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016661001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016661001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	PANTHER
NV2t016663001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t016663001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t016663001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t016663001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	OMA
NV2t016663001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	PANTHER
NV2t016667002.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t016667002.1	biological_process	GO:0006623	protein targeting to vacuole	"The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t016667002.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t016667002.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	PANTHER
NV2t016667002.1	cellular_component	GO:0000813	ESCRT I complex	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]	OMA
NV2t016668001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t016668001.1	biological_process	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	OMA
NV2t016668001.1	biological_process	GO:0070476	rRNA (guanine-N7)-methylation	"The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah]	InterPro
NV2t016668001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016668001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t016668001.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	OMA
NV2t016668001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t016668001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t016670001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t016670001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016672001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016672001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t016672001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016674001.1	biological_process	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	"The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020]	PANTHER
NV2t016675001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	InterPro
NV2t016676001.1	biological_process	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	"The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020]	PANTHER
NV2t016676001.1	biological_process	GO:0042182	ketone catabolic process	"The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]	OMA
NV2t016676001.1	biological_process	GO:0046185	aldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t016676001.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t016676001.1	biological_process	GO:1901617	organic hydroxy compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t016676001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016676001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t016678001.1	biological_process	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	"The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020]	PANTHER
NV2t016678001.1	biological_process	GO:0042182	ketone catabolic process	"The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]	OMA
NV2t016678001.1	biological_process	GO:0046185	aldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t016678001.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t016678001.1	biological_process	GO:1901617	organic hydroxy compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t016678001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016678001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t016679001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	InterPro
NV2t016679002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	InterPro
NV2t016680001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t016680001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t016680001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016680001.1	cellular_component	GO:0070545	PeBoW complex	"A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269]	PANTHER
NV2t016681001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t016681001.1	biological_process	GO:0030048	actin filament-based movement	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]	OMA
NV2t016681001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t016681001.1	biological_process	GO:0051654	establishment of mitochondrion localization	"The directed movement of the mitochondrion to a specific location." [GOC:ai]	OMA
NV2t016681001.1	biological_process	GO:0090140	regulation of mitochondrial fission	"Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t016681001.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	OMA
NV2t016681001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t016681001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t016681001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t016681001.1	molecular_function	GO:0000146	microfilament motor activity	"A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]	OMA
NV2t016681001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016681001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016681001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t016681001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t016681001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t016682001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t016682001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t016682001.1	cellular_component	GO:0005801	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	OMA
NV2t016682001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016682001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t016682002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016682002.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t016683001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t016684001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t016684001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t016687001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016687001.1	molecular_function	GO:0051019	mitogen-activated protein kinase binding	"Binding to a mitogen-activated protein kinase." [GOC:ai]	PANTHER
NV2t016689001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016689001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016692001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t016692001.1	molecular_function	GO:0003968	RNA-dependent RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]	InterPro
NV2t016692002.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t016692002.1	molecular_function	GO:0003968	RNA-dependent RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]	InterPro
NV2t016694001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t016694001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t016694001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016694001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016697001.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	PANTHER
NV2t016697002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t016697002.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	OMA
NV2t016697002.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	PANTHER
NV2t016697002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016697002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t016697003.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	PANTHER
NV2t016698001.1	biological_process	GO:0035024	negative regulation of Rho protein signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	OMA
NV2t016698001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t016698001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t016698001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t016698001.1	cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]	OMA
NV2t016698001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t016698001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016698001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t016699001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t016699001.1	biological_process	GO:0051642	centrosome localization	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t016699001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	OMA
NV2t016699001.1	biological_process	GO:0061512	protein localization to cilium	"A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph]	PANTHER
NV2t016699001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t016699001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t016699001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t016699001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t016701001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t016702001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t016702001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t016702001.1	cellular_component	GO:0005673	transcription factor TFIIE complex	"A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462]	PANTHER
NV2t016703001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016705001.1	biological_process	GO:0018022	peptidyl-lysine methylation	"The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]	InterPro
NV2t016705001.1	biological_process	GO:0018026	peptidyl-lysine monomethylation	"The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]	PANTHER
NV2t016705001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016708001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t016708001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t016708001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	PANTHER
NV2t016708001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t016708001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t016708001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t016708001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t016708001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016709001.1	biological_process	GO:0045669	positive regulation of osteoblast differentiation	"Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]	PANTHER
NV2t016710001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t016710001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t016710001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t016710001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t016710001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t016710001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016710001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t016711001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016711001.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	InterPro
NV2t016713001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t016713001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	OMA
NV2t016713001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t016713001.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	OMA
NV2t016713001.1	biological_process	GO:0071712	obsolete ER-associated misfolded protein catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [PMID:14607247, PMID:19520858]	PANTHER
NV2t016713001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t016713001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t016713001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t016713001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t016713002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t016713002.1	biological_process	GO:0071712	obsolete ER-associated misfolded protein catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [PMID:14607247, PMID:19520858]	PANTHER
NV2t016714001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016714002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016714003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016714004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016715001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t016715001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t016715001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t016716001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t016716001.1	molecular_function	GO:0016853	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	InterPro
NV2t016716001.1	molecular_function	GO:0050121	N-acylglucosamine 2-epimerase activity	"Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN]	PANTHER
NV2t016718001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016718001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016718001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016719001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016719001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016721001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016721001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016721002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016721002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016721002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016723001.1	biological_process	GO:0007143	female meiotic nuclear division	"A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw]	OMA
NV2t016723001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t016723001.1	biological_process	GO:0030046	parallel actin filament bundle assembly	"Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194]	OMA
NV2t016723001.1	biological_process	GO:0033206	meiotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t016723001.1	biological_process	GO:0036089	cleavage furrow formation	"Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell." [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590]	OMA
NV2t016723001.1	biological_process	GO:0045010	actin nucleation	"The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]	OMA
NV2t016723001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t016723001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t016723001.1	biological_process	GO:0051295	establishment of meiotic spindle localization	"The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]	OMA
NV2t016723001.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	OMA
NV2t016723001.1	biological_process	GO:0051639	actin filament network formation	"The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]	PANTHER
NV2t016723001.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t016723001.1	biological_process	GO:2000781	positive regulation of double-strand break repair	"Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t016723001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t016723001.1	cellular_component	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	OMA
NV2t016723001.1	cellular_component	GO:0032154	cleavage furrow	"The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409]	OMA
NV2t016723001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t016724001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t016724001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016724001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t016724001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t016724001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t016724001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t016724001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016724001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t016724001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t016724001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016724001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016725001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t016725001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t016725001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t016725001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t016725001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t016725001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t016725001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t016725001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t016727001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016727001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t016727001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016727001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t016727001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016729001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016729001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016729001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t016729001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016729001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016729001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016729001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016730001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016730001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016730001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t016730001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t016730001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016730001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016730001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016731001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t016731001.1	biological_process	GO:0006562	proline catabolic process	"The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t016731001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016731001.1	molecular_function	GO:0004657	proline dehydrogenase activity	"Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [RHEA:23784]	OMA
NV2t016731001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t016731001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016731001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t016731001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t016733001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t016733001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t016733001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t016733002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t016736001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016736001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016736001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016737001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t016737001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016737001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t016737001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016737001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	InterPro
NV2t016737001.1	molecular_function	GO:0019104	DNA N-glycosylase activity	"Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]	InterPro
NV2t016737001.1	molecular_function	GO:0019104	DNA N-glycosylase activity	"Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]	OMA
NV2t016737001.1	molecular_function	GO:0019104	DNA N-glycosylase activity	"Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]	PANTHER
NV2t016737001.1	molecular_function	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate." [PMID:1698278, RHEA:66592]	OMA
NV2t016739001.1	biological_process	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	"The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]	OMA
NV2t016739001.1	molecular_function	GO:0019135	deoxyhypusine monooxygenase activity	"Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29]	OMA
NV2t016740001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016740001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	PANTHER
NV2t016740001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t016740001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016741001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t016741001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t016741001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t016741001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016741001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t016741001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t016741001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016743001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t016743001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	OMA
NV2t016743001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	PANTHER
NV2t016745001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t016745001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t016746001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t016746001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016746001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016747001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016747002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t016749001.1	biological_process	GO:0007041	lysosomal transport	"The directed movement of substances into, out of or within a lysosome." [GOC:ai]	OMA
NV2t016749001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t016749001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t016749001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t016749001.1	cellular_component	GO:0000938	GARP complex	"A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]	OMA
NV2t016749001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016749001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t016749001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t016750001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016750001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016750001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016750001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t016750002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016750002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t016750002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t016750002.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t016750002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016750002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016750002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016750002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t016750002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016750002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016750002.1	molecular_function	GO:0015459	potassium channel regulator activity	"Binds to and modulates the activity of a potassium channel." [GOC:dos, GOC:mah]	OMA
NV2t016750002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t016750002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t016751001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	InterPro
NV2t016751001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016751002.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	InterPro
NV2t016751002.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	OMA
NV2t016751002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016751002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016752001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016752001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016753001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t016753001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t016754001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t016754001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t016754001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t016754001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t016754002.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t016755001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016756001.1	biological_process	GO:0051684	maintenance of Golgi location	"Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016756002.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t016756002.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t016756002.1	biological_process	GO:0051642	centrosome localization	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t016756002.1	biological_process	GO:0051645	Golgi localization	"Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t016756002.1	biological_process	GO:0051651	maintenance of location in cell	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]	OMA
NV2t016756002.1	biological_process	GO:0051684	maintenance of Golgi location	"Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016756002.1	cellular_component	GO:0031616	spindle pole centrosome	"A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]	OMA
NV2t016756003.1	biological_process	GO:0051684	maintenance of Golgi location	"Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016756004.1	biological_process	GO:0051684	maintenance of Golgi location	"Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016756005.1	biological_process	GO:0051684	maintenance of Golgi location	"Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016757001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016757001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016757001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016757002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016757002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016757004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016757004.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016758001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016758002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016758002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016759001.1	biological_process	GO:0006165	obsolete nucleoside diphosphate phosphorylation	"OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	OMA
NV2t016759001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t016759001.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	OMA
NV2t016759001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t016759001.1	biological_process	GO:0009206	purine ribonucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t016759001.1	biological_process	GO:0030308	negative regulation of cell growth	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t016759001.1	biological_process	GO:0045839	negative regulation of mitotic nuclear division	"Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t016759001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016759001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t016759002.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t016759003.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t016759004.1	biological_process	GO:0006241	CTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732]	InterPro
NV2t016761001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016761001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t016761001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016761002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016761002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t016761003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016761003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016761003.1	biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling]	OMA
NV2t016761003.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t016761003.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t016761003.1	biological_process	GO:0030178	negative regulation of Wnt signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t016761003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t016761003.1	biological_process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	"Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT." [GOC:bf]	OMA
NV2t016761003.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t016761003.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t016761003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016761003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016761003.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t016761003.1	molecular_function	GO:0004707	MAP kinase activity	"Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]	OMA
NV2t016761003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016761003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016761003.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t016761003.1	molecular_function	GO:0042169	SH2 domain binding	"Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017]	OMA
NV2t016761003.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	OMA
NV2t016765001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t016766001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t016766001.1	biological_process	GO:0006108	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t016766001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	InterPro
NV2t016766001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t016766001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016766001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016766001.1	molecular_function	GO:0016615	malate dehydrogenase activity	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]	InterPro
NV2t016766001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t016766001.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	InterPro
NV2t016766001.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	OMA
NV2t016766001.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	PANTHER
NV2t016774001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016774001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016774002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016774002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016774003.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t016774003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016774003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016774003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016774004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016774004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016775001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t016775001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016775001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016775001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016775001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016775002.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t016775002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016775002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016775003.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t016775003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016775003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016775004.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t016775004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016775004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016775005.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t016775005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016775005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016775006.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	PANTHER
NV2t016775006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016775006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016776001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016776001.1	biological_process	GO:0007228	obsolete positive regulation of hh target transcription factor activity	"OBSOLETE. Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936]	PANTHER
NV2t016776001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016778001.1	biological_process	GO:0006836	neurotransmitter transport	"The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]	OMA
NV2t016778001.1	biological_process	GO:0015812	gamma-aminobutyric acid transport	"The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t016778001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t016778001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016778001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016778001.1	molecular_function	GO:0005283	amino acid:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]	OMA
NV2t016778001.1	molecular_function	GO:0008028	monocarboxylic acid transmembrane transporter activity	"Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]	OMA
NV2t016778001.1	molecular_function	GO:0015378	sodium:chloride symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-]	OMA
NV2t016779001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t016779001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t016779001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t016779001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t016779001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t016779001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016779001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016780001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t016780001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t016780001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t016780001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t016780001.1	molecular_function	GO:0008097	5S rRNA binding	"Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t016784001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t016784001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t016784001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016784001.1	biological_process	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	OMA
NV2t016784001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t016784001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t016784001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t016784001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016784001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t016784001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t016784001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t016785001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t016785001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t016785001.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t016785001.1	biological_process	GO:0051209	release of sequestered calcium ion into cytosol	"The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]	PANTHER
NV2t016785001.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t016785001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016785001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t016786001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016786001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t016789001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t016789001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016789001.1	molecular_function	GO:0047631	ADP-ribose diphosphatase activity	"Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]	InterPro
NV2t016789001.1	molecular_function	GO:0047631	ADP-ribose diphosphatase activity	"Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]	OMA
NV2t016790001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t016790001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t016790001.1	molecular_function	GO:0070300	phosphatidic acid binding	"Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [CHEBI:16337, GOC:jp, ISBN:0198506732]	OMA
NV2t016790001.1	molecular_function	GO:0070300	phosphatidic acid binding	"Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [CHEBI:16337, GOC:jp, ISBN:0198506732]	PANTHER
NV2t016791001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t016791001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016791001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016791001.1	molecular_function	GO:0008297	single-stranded DNA exodeoxyribonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah]	OMA
NV2t016791001.1	molecular_function	GO:0035312	5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]	OMA
NV2t016791001.1	molecular_function	GO:0045145	single-stranded DNA 5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101]	InterPro
NV2t016791001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t016791002.1	molecular_function	GO:0045145	single-stranded DNA 5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101]	InterPro
NV2t016792001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	InterPro
NV2t016792001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t016792001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016792002.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	InterPro
NV2t016792002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016792003.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	InterPro
NV2t016792003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016792004.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	InterPro
NV2t016792004.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t016793001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016793001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016793002.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016793002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016793003.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016793003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016793004.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016793004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016793005.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016793005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016793006.1	biological_process	GO:0007040	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	OMA
NV2t016793006.1	biological_process	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	OMA
NV2t016793006.1	biological_process	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	OMA
NV2t016793006.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t016793006.1	biological_process	GO:0043524	negative regulation of neuron apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t016793006.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t016793006.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t016793006.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t016793006.1	biological_process	GO:0072337	modified amino acid transport	"The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t016793006.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t016793006.1	biological_process	GO:1902475	L-alpha-amino acid transmembrane transport	"The directed movement of L-alpha-amino acid across a membrane by means of some agent such as a transporter or a pore." [GOC:kmv, GOC:TermGenie, PMID:14668347]	OMA
NV2t016793006.1	biological_process	GO:1990822	basic amino acid transmembrane transport	"The directed movement of basic amino acids from one side of a membrane to the other." [GOC:dph, GOC:vw]	OMA
NV2t016793006.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t016793006.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t016793006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016793006.1	cellular_component	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	OMA
NV2t016793006.1	cellular_component	GO:0098852	lytic vacuole membrane	"The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos]	OMA
NV2t016793006.1	cellular_component	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t016793006.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t016796001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t016796001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t016800001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t016800001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016804001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t016804001.1	molecular_function	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]	OMA
NV2t016806001.1	biological_process	GO:0042823	pyridoxal phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]	InterPro
NV2t016806001.1	biological_process	GO:0042823	pyridoxal phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]	OMA
NV2t016806001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016806001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t016806001.1	cellular_component	GO:1903600	glutaminase complex	"A protein complex which is capable of glutaminase activity." [GO_REF:0000088, GOC:TermGenie, PMID:14764090]	PANTHER
NV2t016806001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t016808001.1	biological_process	GO:0042823	pyridoxal phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]	InterPro
NV2t016808001.1	biological_process	GO:0042823	pyridoxal phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl]	PANTHER
NV2t016809001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t016809001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016817001.1	biological_process	GO:0019216	regulation of lipid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]	PANTHER
NV2t016820001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t016820001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t016820001.1	biological_process	GO:0048285	organelle fission	"The creation of two or more organelles by division of one organelle." [GOC:jid]	OMA
NV2t016820001.1	biological_process	GO:0051125	regulation of actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]	OMA
NV2t016820001.1	biological_process	GO:0140285	endosome fission	"The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane." [PMID:25416943, PMID:30220460]	PANTHER
NV2t016820001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t016820001.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	InterPro
NV2t016820001.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	OMA
NV2t016820002.1	biological_process	GO:0140285	endosome fission	"The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane." [PMID:25416943, PMID:30220460]	PANTHER
NV2t016820002.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	InterPro
NV2t016820003.1	biological_process	GO:0140285	endosome fission	"The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane." [PMID:25416943, PMID:30220460]	PANTHER
NV2t016820003.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	InterPro
NV2t016822001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t016822001.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	OMA
NV2t016822001.1	cellular_component	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	OMA
NV2t016822001.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	PANTHER
NV2t016822001.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	InterPro
NV2t016822001.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	OMA
NV2t016823001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016823001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016823001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016823001.1	molecular_function	GO:0015267	channel activity	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016828001.1	biological_process	GO:0003352	regulation of cilium movement	"Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]	OMA
NV2t016828001.1	biological_process	GO:0060285	cilium-dependent cell motility	"Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]	OMA
NV2t016828001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	InterPro
NV2t016828001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	OMA
NV2t016828001.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t016829001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t016829001.1	biological_process	GO:0019359	nicotinamide nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]	OMA
NV2t016829001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t016829001.1	molecular_function	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t016829001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t016829001.1	molecular_function	GO:0033735	aspartate dehydrogenase activity	"Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21]	InterPro
NV2t016829001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t016831001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t016831001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t016831001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016831001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016831001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t016832001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016832001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016832001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016832001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t016833001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	InterPro
NV2t016834001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016834001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t016834001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016835001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t016835001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016835001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016835001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016836001.1	biological_process	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	OMA
NV2t016836001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t016836001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t016836001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016836001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t016836001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t016836001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016836001.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	InterPro
NV2t016836001.1	molecular_function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity	"Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164]	OMA
NV2t016836001.1	molecular_function	GO:0070191	obsolete methionine-R-sulfoxide reductase activity	"OBSOLETE. Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin." [GOC:mcc, PMID:17535911, PMID:19049972]	PANTHER
NV2t016837001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t016837001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t016841001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016841001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t016842001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016842001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016842001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016844001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016844001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016844001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016848001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016848002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016849001.1	biological_process	GO:0015711	organic anion transport	"The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc]	OMA
NV2t016849001.1	biological_process	GO:0035627	ceramide transport	"The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart]	OMA
NV2t016849001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016849001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t016849001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t016849001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t016849001.1	molecular_function	GO:0051861	glycolipid binding	"Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [PMID:19635802]	OMA
NV2t016849001.1	molecular_function	GO:0097001	ceramide binding	"Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [GOC:sart]	OMA
NV2t016849001.1	molecular_function	GO:0120013	lipid transfer activity	"Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	InterPro
NV2t016849001.1	molecular_function	GO:0120014	phospholipid transfer activity	"Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t016849001.1	molecular_function	GO:0120017	ceramide transfer activity	"Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t016851001.1	biological_process	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	PANTHER
NV2t016851002.1	biological_process	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	PANTHER
NV2t016851003.1	biological_process	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	PANTHER
NV2t016854001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016854001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016855001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016855001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t016855001.1	molecular_function	GO:0004849	uridine kinase activity	"Catalysis of the reaction: ATP + uridine = ADP + UMP." [RHEA:16825]	OMA
NV2t016855001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016855001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t016857001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t016857001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016857001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t016859001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016859001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016859001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016860001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016860001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t016860001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016862001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t016862001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t016862001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016862001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016862001.1	molecular_function	GO:0030552	cAMP binding	"Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]	InterPro
NV2t016863001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t016863001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t016863001.1	biological_process	GO:0030277	maintenance of gastrointestinal epithelium	"Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah]	OMA
NV2t016863001.1	biological_process	GO:0060390	regulation of SMAD protein signal transduction	"Any process that modulates the rate, frequency or extent of SMAD protein signal transduction." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t016863001.1	biological_process	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	OMA
NV2t016863001.1	biological_process	GO:0090287	regulation of cellular response to growth factor stimulus	"Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]	OMA
NV2t016863001.1	biological_process	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t016863001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016863001.1	molecular_function	GO:0016853	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	OMA
NV2t016863001.1	molecular_function	GO:0016853	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	PANTHER
NV2t016863001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t016865001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016865001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t016865001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016865001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016870001.1	biological_process	GO:0001764	neuron migration	"The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators]	OMA
NV2t016870001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t016870001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t016870001.1	biological_process	GO:0007626	locomotory behavior	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]	OMA
NV2t016870001.1	biological_process	GO:0007631	feeding behavior	"Behavior associated with the intake of food." [GOC:mah]	OMA
NV2t016870001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t016870001.1	biological_process	GO:0016558	protein import into peroxisome matrix	"The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]	OMA
NV2t016870001.1	biological_process	GO:0016560	protein import into peroxisome matrix, docking	"The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507]	InterPro
NV2t016870001.1	biological_process	GO:0019395	fatty acid oxidation	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t016870001.1	biological_process	GO:0051640	organelle localization	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]	OMA
NV2t016870001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t016870001.1	cellular_component	GO:1990351	transporter complex	"A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]	OMA
NV2t016870001.1	cellular_component	GO:1990429	peroxisomal importomer complex	"A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:12667447, PMID:20154681, PMID:22375831]	PANTHER
NV2t016870001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016872001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	OMA
NV2t016872001.1	biological_process	GO:0034198	cellular response to amino acid starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]	OMA
NV2t016872001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t016872001.1	biological_process	GO:0034644	cellular response to UV	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]	OMA
NV2t016872001.1	biological_process	GO:0036499	PERK-mediated unfolded protein response	"The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041]	OMA
NV2t016872001.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t016872001.1	biological_process	GO:1901216	obsolete positive regulation of neuron death	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t016872001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016872001.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t016872001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t016872001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016872001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016872001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016872001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	InterPro
NV2t016872001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t016872001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016872001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t016872001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t016873001.1	biological_process	GO:0000266	mitochondrial fission	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]	OMA
NV2t016873001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t016873001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t016875001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t016875001.1	biological_process	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t016875001.1	biological_process	GO:0002832	negative regulation of response to biotic stimulus	"Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]	OMA
NV2t016875001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t016875001.1	biological_process	GO:0031348	negative regulation of defense response	"Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah]	OMA
NV2t016875001.1	biological_process	GO:0032102	negative regulation of response to external stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t016875001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016875001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016875001.1	biological_process	GO:0050688	regulation of defense response to virus	"Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]	OMA
NV2t016875001.1	biological_process	GO:0062207	regulation of pattern recognition receptor signaling pathway	"Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]	OMA
NV2t016875001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016875001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016875001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016875001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016875002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016875002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016877001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016877001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t016877002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016878001.1	biological_process	GO:0002115	store-operated calcium entry	"A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]	OMA
NV2t016878001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016878001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016878001.1	molecular_function	GO:0015279	store-operated calcium channel activity	"A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]	OMA
NV2t016879001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016879001.1	biological_process	GO:0001838	embryonic epithelial tube formation	"The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]	OMA
NV2t016879001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t016879001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t016879001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t016879001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t016879001.1	biological_process	GO:0043524	negative regulation of neuron apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t016879001.1	biological_process	GO:0048562	embryonic organ morphogenesis	"Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t016879001.1	biological_process	GO:0048592	eye morphogenesis	"The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t016879001.1	biological_process	GO:2000178	negative regulation of neural precursor cell proliferation	"Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]	OMA
NV2t016879001.1	cellular_component	GO:0031519	PcG protein complex	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]	OMA
NV2t016879001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t016879001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016879001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016879001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016879001.1	molecular_function	GO:0032452	histone demethylase activity	"Catalysis of the removal of a methyl group from a histone." [GOC:mah]	PANTHER
NV2t016879001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t016879001.1	molecular_function	GO:0051864	histone H3K36 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16362057]	OMA
NV2t016879002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016879002.1	molecular_function	GO:0032452	histone demethylase activity	"Catalysis of the removal of a methyl group from a histone." [GOC:mah]	PANTHER
NV2t016879003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016879003.1	molecular_function	GO:0032452	histone demethylase activity	"Catalysis of the removal of a methyl group from a histone." [GOC:mah]	PANTHER
NV2t016879004.1	molecular_function	GO:0032452	histone demethylase activity	"Catalysis of the removal of a methyl group from a histone." [GOC:mah]	PANTHER
NV2t016880001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016880001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t016880001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t016880001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t016880001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t016880001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016880001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016880001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016882001.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	InterPro
NV2t016882001.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	PANTHER
NV2t016882002.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	InterPro
NV2t016882002.1	biological_process	GO:0070475	rRNA base methylation	"The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]	PANTHER
NV2t016882002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t016882002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t016882002.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	OMA
NV2t016882002.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t016882002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t016885001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t016887001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t016887001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t016887001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t016887001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	PANTHER
NV2t016887001.1	biological_process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	"Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]	OMA
NV2t016887001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t016887001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t016887001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016887001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016887001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016887001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t016887001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t016887001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t016888001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t016888001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016888001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016888001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016889001.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t016889001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016889001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t016889001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t016889001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t016889001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t016889001.1	biological_process	GO:0007610	behavior	"The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]	OMA
NV2t016889001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t016889001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t016889001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t016889001.1	biological_process	GO:0031667	response to nutrient levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]	OMA
NV2t016889001.1	biological_process	GO:0032869	cellular response to insulin stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t016889001.1	biological_process	GO:0038202	TORC1 signaling	"A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]	OMA
NV2t016889001.1	biological_process	GO:0040012	regulation of locomotion	"Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]	OMA
NV2t016889001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t016889001.1	biological_process	GO:0045927	positive regulation of growth	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]	OMA
NV2t016889001.1	biological_process	GO:0045931	positive regulation of mitotic cell cycle	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t016889001.1	biological_process	GO:0045948	positive regulation of translational initiation	"Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t016889001.1	biological_process	GO:0046627	negative regulation of insulin receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]	OMA
NV2t016889001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t016889001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	OMA
NV2t016889001.1	biological_process	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	OMA
NV2t016889001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016889001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016889001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t016889001.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t016889001.1	molecular_function	GO:0004711	ribosomal protein S6 kinase activity	"Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]	OMA
NV2t016889001.1	molecular_function	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	OMA
NV2t016889001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t016889001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016889001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t016889002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016889002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t016889002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t016889002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016889003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016889003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t016889003.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t016889003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t016890001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016890001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016891001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t016891001.1	molecular_function	GO:0004045	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	InterPro
NV2t016891002.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t016891002.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t016891002.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t016891002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t016891002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016891002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t016891002.1	molecular_function	GO:0004045	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	InterPro
NV2t016891002.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t016891002.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t016892001.1	biological_process	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	"The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783]	OMA
NV2t016892001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	OMA
NV2t016892001.1	biological_process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	"Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators]	OMA
NV2t016892001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	OMA
NV2t016892001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	PANTHER
NV2t016892001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t016892001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t016892001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016892001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t016892001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016892001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t016893001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t016894001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016894001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016894001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016894001.1	molecular_function	GO:0015267	channel activity	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016895001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016895001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016895001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016895001.1	molecular_function	GO:0015267	channel activity	"Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016895002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016895002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016895003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016895003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016895004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016895004.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016895005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016897001.1	biological_process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	"Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]	PANTHER
NV2t016897001.1	molecular_function	GO:0008603	cAMP-dependent protein kinase regulator activity	"Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]	InterPro
NV2t016900001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t016901001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016901001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016901001.1	molecular_function	GO:0004970	glutamate-gated receptor activity	"Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]	OMA
NV2t016901001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t016901001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t016902001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016902001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t016902001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t016903001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016903001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t016903001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t016906001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016906002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016906003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t016906005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016906005.1	molecular_function	GO:0004033	aldo-keto reductase (NADPH) activity	"Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai]	OMA
NV2t016907001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	InterPro
NV2t016907001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t016907001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016907002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	InterPro
NV2t016907002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t016907002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t016908001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016908002.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t016908002.1	biological_process	GO:0022417	protein maturation by protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete]	OMA
NV2t016908002.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t016908002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t016908002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t016908002.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t016908002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t016908002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t016908002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016908002.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t016908002.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t016909001.1	biological_process	GO:0000731	DNA synthesis involved in DNA repair	"Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855]	OMA
NV2t016909001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t016909001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t016909001.1	cellular_component	GO:0043625	delta DNA polymerase complex	"A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]	PANTHER
NV2t016910001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t016910001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	InterPro
NV2t016910001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	OMA
NV2t016912001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t016912001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t016912001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t016912001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t016912001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016912001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016913001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	PANTHER
NV2t016913001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t016913001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t016913002.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	PANTHER
NV2t016913002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t016913002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t016913003.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	PANTHER
NV2t016913003.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t016913003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t016921001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t016921001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t016921001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t016922001.1	biological_process	GO:0061511	centriole elongation	"The centrosome organization process by which a centriole increases in length as part of the process of replication." [GOC:dph, PMID:21576394]	PANTHER
NV2t016923001.1	biological_process	GO:0044458	motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]	PANTHER
NV2t016923001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016923002.1	biological_process	GO:0044458	motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]	PANTHER
NV2t016923002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016923003.1	biological_process	GO:0044458	motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]	PANTHER
NV2t016923003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016928001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016930001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016931001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t016931001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016932001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t016932001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t016932001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t016932001.1	molecular_function	GO:0004896	cytokine receptor activity	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]	OMA
NV2t016932001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016932001.1	molecular_function	GO:0019955	cytokine binding	"Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]	OMA
NV2t016933001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t016935001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	InterPro
NV2t016935001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t016937001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t016937001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t016938001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	InterPro
NV2t016938001.1	biological_process	GO:1900461	positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter	"Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:11046133, PMID:8710886, PMID:9987114]	PANTHER
NV2t016938002.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	InterPro
NV2t016938002.1	biological_process	GO:1900461	positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter	"Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:11046133, PMID:8710886, PMID:9987114]	PANTHER
NV2t016938003.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	InterPro
NV2t016938003.1	biological_process	GO:1900461	positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter	"Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:11046133, PMID:8710886, PMID:9987114]	PANTHER
NV2t016939001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t016939001.1	molecular_function	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	"Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.3.3]	PANTHER
NV2t016939001.1	molecular_function	GO:0008373	sialyltransferase activity	"Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [GOC:cjm, PMID:26192491]	InterPro
NV2t016939001.1	molecular_function	GO:0008373	sialyltransferase activity	"Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [GOC:cjm, PMID:26192491]	OMA
NV2t016941001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t016941001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016941001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016941001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016941001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016943001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t016943001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016943001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016943001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t016944001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016944001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016944001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t016947001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	InterPro
NV2t016947001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t016947001.1	biological_process	GO:1901673	regulation of mitotic spindle assembly	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]	PANTHER
NV2t016948001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t016948001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t016948001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016948001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t016952001.1	biological_process	GO:0006658	phosphatidylserine metabolic process	"The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t016952001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t016952001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016952001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016953001.1	biological_process	GO:0045017	glycerolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	InterPro
NV2t016953001.1	biological_process	GO:0045017	glycerolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t016953001.1	molecular_function	GO:0004144	diacylglycerol O-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]	OMA
NV2t016954001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t016954001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t016954001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t016954001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016954001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016954001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016954001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016955001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016955001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t016955001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016955001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t016955001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t016958001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t016958001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t016958001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016958001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t016958001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t016958001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t016958001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t016960001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t016960001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t016960001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	InterPro
NV2t016961001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016961001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t016961001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t016961002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016961002.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t016961003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016961003.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t016965001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t016965001.1	biological_process	GO:2001235	positive regulation of apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t016965001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t016965001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t016965001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t016965001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t016968001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016968001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t016968001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t016969001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016969001.1	molecular_function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t016971001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t016971001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t016971002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t016972001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016972001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t016972001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t016972001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t016972002.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t016972002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t016973001.1	cellular_component	GO:0043291	RAVE complex	"A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802]	PANTHER
NV2t016974001.1	biological_process	GO:0009068	aspartate family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t016974001.1	molecular_function	GO:0008743	L-threonine 3-dehydrogenase activity	"Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + CO2 + NADH." [EC:1.1.1.103, RHEA:13161]	PANTHER
NV2t016974001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t016975001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t016975001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t016975001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t016977001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t016977001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t016977001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t016977001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t016977001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t016980001.1	biological_process	GO:0014074	response to purine-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:ef]	OMA
NV2t016980001.1	biological_process	GO:0035590	purinergic nucleotide receptor signaling pathway	"The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:9755289]	OMA
NV2t016980001.1	biological_process	GO:0046683	response to organophosphorus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544]	OMA
NV2t016980001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t016980001.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	InterPro
NV2t016980001.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t016980001.1	biological_process	GO:1902074	response to salt	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t016980001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t016980001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t016980001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t016980001.1	molecular_function	GO:0099094	ligand-gated monoatomic cation channel activity	"Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t016982001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t016982001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016984001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t016984001.1	molecular_function	GO:0009045	xylose isomerase activity	"Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5]	InterPro
NV2t016984001.1	molecular_function	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]	OMA
NV2t016985001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t016985001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t016986001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t016986001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t016986001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t016986001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t016986001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016986001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016986001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t016989001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016989001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016990001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t016990001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016990001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016990002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t016990002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016990002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016990003.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t016990003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016990003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t016993001.1	biological_process	GO:0030890	positive regulation of B cell proliferation	"Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah]	PANTHER
NV2t016993001.1	molecular_function	GO:0003953	NAD+ nucleosidase activity	"Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]	InterPro
NV2t016993001.1	molecular_function	GO:0003953	NAD+ nucleosidase activity	"Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]	OMA
NV2t016994001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t016994001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t016994001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	PANTHER
NV2t016994001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t016994001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t016996001.1	biological_process	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]	OMA
NV2t016996001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t016996001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t016996001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t016996001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t016996001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t016996001.1	molecular_function	GO:0004535	poly(A)-specific ribonuclease activity	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]	OMA
NV2t017004001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t017004001.1	biological_process	GO:0000165	MAPK cascade	"An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [PMID:20811974, PMID:9561267]	OMA
NV2t017004001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t017004001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t017004001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t017004001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t017004001.1	biological_process	GO:0031400	negative regulation of protein modification process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	OMA
NV2t017004001.1	biological_process	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	OMA
NV2t017004001.1	biological_process	GO:0034613	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	PANTHER
NV2t017004001.1	biological_process	GO:0044092	negative regulation of molecular function	"Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]	OMA
NV2t017004001.1	biological_process	GO:0046827	positive regulation of protein export from nucleus	"Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]	OMA
NV2t017004001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t017004001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017004001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017004001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017004001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t017004001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t017004001.1	molecular_function	GO:0050815	phosphoserine residue binding	"Binding to a phosphorylated serine residue within a protein." [GOC:ai]	OMA
NV2t017006001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t017006001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017006001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t017006001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017006001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017007001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t017007001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t017007001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t017007001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t017007001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t017007002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t017008001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t017008001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t017008001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017008001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017008001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t017008001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t017008001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017008001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017008002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t017008002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017008002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017008002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t017008002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017008003.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t017008003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017008003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017008003.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t017008003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017009001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t017009001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t017009001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t017009001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t017009001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t017009001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t017010001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t017010001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017010001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017010001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017011001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017011001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017011001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	PANTHER
NV2t017012001.1	biological_process	GO:0051646	mitochondrion localization	"Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t017014001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t017014001.1	cellular_component	GO:0005761	mitochondrial ribosome	"A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017016001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t017016001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t017016001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	OMA
NV2t017016001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t017016001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017016001.1	cellular_component	GO:0070877	microprocessor complex	"A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994]	PANTHER
NV2t017016001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t017016001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t017016001.1	molecular_function	GO:0004525	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	OMA
NV2t017019001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t017019001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t017019001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017019001.1	molecular_function	GO:0003884	D-amino-acid oxidase activity	"Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3]	InterPro
NV2t017019001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017019001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t017019001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t017019001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t017021001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017021001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017021001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t017021001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017021001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017022001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017022001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017022001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017022001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017023001.1	cellular_component	GO:0045254	pyruvate dehydrogenase complex	"A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:36863425]	PANTHER
NV2t017023001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017028001.1	biological_process	GO:0000707	meiotic DNA recombinase assembly	"During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983]	OMA
NV2t017028001.1	biological_process	GO:0007062	sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194]	OMA
NV2t017028001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t017028001.1	biological_process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]	OMA
NV2t017028001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t017028001.1	cellular_component	GO:0033065	Rad51C-XRCC3 complex	"A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, GOC:vw, PMID:12427746, PMID:16093548, PMID:17114795]	PANTHER
NV2t017028001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t017028001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t017028001.1	molecular_function	GO:0000400	four-way junction DNA binding	"Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]	OMA
NV2t017028001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017028001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t017028001.1	molecular_function	GO:0008821	crossover junction DNA endonuclease activity	"Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.21.10]	OMA
NV2t017028001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t017028001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t017030001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t017030001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t017030001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017030001.1	molecular_function	GO:0016408	C-acyltransferase activity	"Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]	OMA
NV2t017030001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017030001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t017033001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	PANTHER
NV2t017033002.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	PANTHER
NV2t017034001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t017034001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t017034001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t017034001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t017034001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t017036001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017036001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017036001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017037001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t017037001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017037001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017037001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t017037002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t017037002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017037003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t017037003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017039001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017039001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t017039001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017039001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	OMA
NV2t017039001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t017039001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t017039001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017039001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t017039001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t017039001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t017041001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017041001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017041001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t017041001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t017041001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017041001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017041001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t017041002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017041002.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t017041002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017045001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017045001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017045002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017045002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017045003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017045003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t017045003.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t017045003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t017045003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017045003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017045003.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t017045003.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t017045003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017045004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017045004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017045005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017045005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017045006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017045006.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017045007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017045007.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017045008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017045008.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017046001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t017046001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t017046002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t017048001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t017048001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t017048001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017048001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017048001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017048001.1	molecular_function	GO:0072545	L-tyrosine binding	"Binding to L-tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:mah]	InterPro
NV2t017049001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t017049001.1	biological_process	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	"The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]	PANTHER
NV2t017049001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017054001.1	biological_process	GO:0015804	neutral amino acid transport	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t017054001.1	biological_process	GO:0034763	negative regulation of transmembrane transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]	OMA
NV2t017054001.1	biological_process	GO:0051955	regulation of amino acid transport	"Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t017054001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017054001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017054001.1	molecular_function	GO:0015175	neutral L-amino acid transmembrane transporter activity	"Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017054001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017057001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017057001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t017057001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t017057002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017057002.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t017057002.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t017057002.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	InterPro
NV2t017057003.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017057003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017057003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t017057003.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t017057003.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	OMA
NV2t017057003.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	InterPro
NV2t017057003.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t017057004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017057004.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t017057004.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	InterPro
NV2t017057005.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017057005.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t017057005.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t017058001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	InterPro
NV2t017058001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t017058002.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	InterPro
NV2t017059001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t017059001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t017059001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t017059001.1	biological_process	GO:0006268	DNA unwinding involved in DNA replication	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]	OMA
NV2t017059001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t017059001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t017059001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t017059001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t017059001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t017059001.1	biological_process	GO:0034502	protein localization to chromosome	"Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah]	OMA
NV2t017059001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t017059001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t017059001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	OMA
NV2t017059001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t017059001.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	OMA
NV2t017059001.1	cellular_component	GO:0005662	DNA replication factor A complex	"A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]	OMA
NV2t017059001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t017059001.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	OMA
NV2t017059001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017059001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t017059001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017059001.1	molecular_function	GO:0043047	single-stranded telomeric DNA binding	"Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]	OMA
NV2t017060001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017061001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017061002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t017061002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017061002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017061003.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t017061003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017061003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017062001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	InterPro
NV2t017062001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t017063001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t017063001.1	biological_process	GO:0032979	protein insertion into mitochondrial inner membrane from matrix	"The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [GOC:vw, PMID:12880202, PMID:15473843]	OMA
NV2t017063001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t017063001.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	OMA
NV2t017063001.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	PANTHER
NV2t017063001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t017063001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017063001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017063001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t017063003.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	PANTHER
NV2t017063003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017063004.1	biological_process	GO:0034551	mitochondrial respiratory chain complex III assembly	"The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc]	PANTHER
NV2t017063004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017065001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t017065002.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t017066001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t017066002.1	biological_process	GO:0006119	oxidative phosphorylation	"The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309]	OMA
NV2t017066002.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t017066002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t017066002.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t017067001.1	biological_process	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	OMA
NV2t017067001.1	biological_process	GO:0009612	response to mechanical stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]	OMA
NV2t017067001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017067001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t017067001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t017069001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017069001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017069001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017069002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017069003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017070001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t017070001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t017070001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t017070001.1	biological_process	GO:0045792	negative regulation of cell size	"Any process that reduces cell size." [GOC:go_curators]	OMA
NV2t017070001.1	biological_process	GO:1903940	negative regulation of TORC2 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430]	OMA
NV2t017070001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t017070001.1	biological_process	GO:1904262	negative regulation of TORC1 signaling	"Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t017070001.1	biological_process	GO:2001233	regulation of apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t017070001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017072001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t017072001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017072001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017072001.1	molecular_function	GO:0016411	acylglycerol O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]	OMA
NV2t017072001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017072001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t017072001.1	molecular_function	GO:0042171	lysophosphatidic acid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]	OMA
NV2t017074001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017074001.1	molecular_function	GO:0072572	poly-ADP-D-ribose binding	"Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964]	InterPro
NV2t017074002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017074002.1	molecular_function	GO:0072572	poly-ADP-D-ribose binding	"Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964]	InterPro
NV2t017074003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017074003.1	molecular_function	GO:0072572	poly-ADP-D-ribose binding	"Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964]	InterPro
NV2t017076001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t017076001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t017076001.1	biological_process	GO:0032784	regulation of DNA-templated transcription elongation	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	OMA
NV2t017076001.1	biological_process	GO:0032784	regulation of DNA-templated transcription elongation	"Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	PANTHER
NV2t017076001.1	cellular_component	GO:0000347	THO complex	"The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]	OMA
NV2t017077001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t017077001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t017077001.1	molecular_function	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]	OMA
NV2t017077002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t017077002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	PANTHER
NV2t017077003.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	PANTHER
NV2t017077004.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	PANTHER
NV2t017077005.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	PANTHER
NV2t017078001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017078001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t017078002.1	biological_process	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	OMA
NV2t017078002.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t017078002.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t017078002.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t017078002.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t017078002.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t017078002.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t017078002.1	biological_process	GO:0048738	cardiac muscle tissue development	"The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]	OMA
NV2t017078002.1	biological_process	GO:0051171	obsolete regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t017078002.1	biological_process	GO:0051282	regulation of sequestering of calcium ion	"Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]	OMA
NV2t017078002.1	biological_process	GO:0060415	muscle tissue morphogenesis	"The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph]	OMA
NV2t017078002.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t017078002.1	biological_process	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	OMA
NV2t017078002.1	biological_process	GO:1901019	regulation of calcium ion transmembrane transporter activity	"Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie]	OMA
NV2t017078002.1	biological_process	GO:2001257	regulation of cation channel activity	"Any process that modulates the frequency, rate or extent of cation channel activity." [GOC:BHF]	OMA
NV2t017078002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017078002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017078002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017078002.1	cellular_component	GO:0016529	sarcoplasmic reticulum	"A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684]	OMA
NV2t017078002.1	cellular_component	GO:0030018	Z disc	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]	OMA
NV2t017078002.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t017078002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t017078002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t017078002.1	molecular_function	GO:0005528	FK506 binding	"Binding to a 23-membered macrolide lactone FK506." [GOC:jl]	OMA
NV2t017078002.1	molecular_function	GO:0034713	type I transforming growth factor beta receptor binding	"Binding to a type I transforming growth factor beta receptor." [GOC:BHF, GOC:mah]	OMA
NV2t017078002.1	molecular_function	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	OMA
NV2t017078002.1	molecular_function	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	OMA
NV2t017078002.1	molecular_function	GO:0048185	activin binding	"Binding to activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah]	OMA
NV2t017079001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017079001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017079001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017079001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017080001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017080001.1	biological_process	GO:0044275	obsolete cellular carbohydrate catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t017080001.1	biological_process	GO:1901658	glycosyl compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t017080001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t017080001.1	molecular_function	GO:0004566	beta-glucuronidase activity	"Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31]	OMA
NV2t017080001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t017080001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	PANTHER
NV2t017080002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017080002.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t017080003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017080003.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	PANTHER
NV2t017081003.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t017081003.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t017082001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t017082001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017083001.1	biological_process	GO:0070987	error-free translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh]	PANTHER
NV2t017083001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017083002.1	biological_process	GO:0070987	error-free translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh]	PANTHER
NV2t017083002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017083002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t017084001.1	biological_process	GO:0006646	phosphatidylethanolamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]	PANTHER
NV2t017084001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t017084001.1	biological_process	GO:0046337	phosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732]	OMA
NV2t017084001.1	biological_process	GO:0046474	glycerophospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t017084001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017084001.1	molecular_function	GO:0070567	cytidylyltransferase activity	"Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]	OMA
NV2t017085001.1	biological_process	GO:0006661	phosphatidylinositol biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]	OMA
NV2t017085001.1	biological_process	GO:0006661	phosphatidylinositol biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]	PANTHER
NV2t017085001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t017085001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017085001.1	molecular_function	GO:0003881	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity	"Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+." [EC:2.7.8.11, RHEA:11580]	OMA
NV2t017085001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t017085001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	InterPro
NV2t017085002.1	biological_process	GO:0006661	phosphatidylinositol biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]	PANTHER
NV2t017085002.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	InterPro
NV2t017090001.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	InterPro
NV2t017090001.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	OMA
NV2t017090002.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	InterPro
NV2t017090003.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	InterPro
NV2t017091001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	InterPro
NV2t017091001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	OMA
NV2t017091001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	OMA
NV2t017091001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017091001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t017091001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t017091001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t017091001.1	molecular_function	GO:0008252	nucleotidase activity	"Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [RHEA:22140]	OMA
NV2t017091001.1	molecular_function	GO:0052745	inositol phosphate phosphatase activity	"Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]	OMA
NV2t017091002.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	InterPro
NV2t017091002.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t017092001.1	biological_process	GO:0006448	regulation of translational elongation	"Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]	OMA
NV2t017092001.1	biological_process	GO:0018202	peptidyl-histidine modification	"The modification of peptidyl-histidine." [GOC:ma]	OMA
NV2t017092001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t017092001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t017092001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t017092001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017092001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t017092001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t017092001.1	molecular_function	GO:0090560	2-(3-amino-3-carboxypropyl)histidine synthase activity	"Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [GOC:pde, PMID:15485916]	InterPro
NV2t017096001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t017097001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t017098001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t017098002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t017098003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t017099001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017099001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t017101001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	PANTHER
NV2t017104001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017106001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t017106001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	InterPro
NV2t017106001.1	biological_process	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	"The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]	OMA
NV2t017106001.1	biological_process	GO:0090646	mitochondrial tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw]	OMA
NV2t017106001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017106001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017106001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017106001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017106001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t017106001.1	molecular_function	GO:0052381	tRNA dimethylallyltransferase activity	"Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine." [EC:2.5.1.75]	InterPro
NV2t017106001.1	molecular_function	GO:0052381	tRNA dimethylallyltransferase activity	"Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine." [EC:2.5.1.75]	PANTHER
NV2t017106001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t017109001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017109001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t017109001.1	molecular_function	GO:0004566	beta-glucuronidase activity	"Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31]	OMA
NV2t017109001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	PANTHER
NV2t017113001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t017113001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t017113001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t017113001.1	biological_process	GO:0032006	regulation of TOR signaling	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t017113001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017113001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t017113001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017115001.1	biological_process	GO:0015804	neutral amino acid transport	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t017115001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017115002.1	biological_process	GO:0015804	neutral amino acid transport	"The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t017115002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017115002.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t017115002.1	molecular_function	GO:0046943	carboxylic acid transmembrane transporter activity	"Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]	OMA
NV2t017116001.1	biological_process	GO:0016082	synaptic vesicle priming	"A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane." [GOC:mah, PMID:15217342, PMID:23060190]	OMA
NV2t017116001.1	biological_process	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	"Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]	OMA
NV2t017116001.1	biological_process	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	"Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940]	PANTHER
NV2t017116001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017116001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t017116001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t017116001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t017117001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	InterPro
NV2t017118001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t017118001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t017118001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t017118001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t017118001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t017118001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t017118001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t017118001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017118001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017119001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t017121001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t017121001.1	biological_process	GO:0008593	regulation of Notch signaling pathway	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t017121001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t017121001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017121001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	InterPro
NV2t017121001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	OMA
NV2t017121001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	PANTHER
NV2t017122001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017122001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t017123001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017124001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017124001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017124001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017124002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017124002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017125001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t017125001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t017125001.1	biological_process	GO:0031125	rRNA 3'-end processing	"Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah]	OMA
NV2t017125001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t017125001.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	OMA
NV2t017125001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t017125001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t017125001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t017125001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t017125001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017125001.1	molecular_function	GO:0047485	obsolete protein N-terminus binding	"OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t017128001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t017129001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t017129001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017129001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t017131001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t017131001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017131001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t017136001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t017137001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017137001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t017137001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t017137001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t017139001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017139001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t017139001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t017139001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t017141001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t017145002.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t017145002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017146001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017146001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t017147001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017147001.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	OMA
NV2t017147001.1	biological_process	GO:0044262	obsolete cellular carbohydrate metabolic process	"OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t017147001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t017147001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	InterPro
NV2t017147001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	OMA
NV2t017147001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t017147002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017149001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017149001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017149002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017149002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017151001.1	biological_process	GO:0009395	phospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t017151001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	InterPro
NV2t017151001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t017152001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t017153001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017153001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t017154001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t017156001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017156001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017156001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	PANTHER
NV2t017158001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t017158001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017159001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t017159001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017159001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017159001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t017160001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017164001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t017164001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017164001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017164002.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t017164002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017164002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017164003.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t017164003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017164003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017164004.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t017164004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017164004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017164005.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t017164005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017164005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017169001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017169001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t017169001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t017169001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t017169001.1	molecular_function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019]	PANTHER
NV2t017170001.1	biological_process	GO:0032786	positive regulation of DNA-templated transcription, elongation	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	PANTHER
NV2t017170002.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t017170002.1	biological_process	GO:0032786	positive regulation of DNA-templated transcription, elongation	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	OMA
NV2t017170002.1	biological_process	GO:0032786	positive regulation of DNA-templated transcription, elongation	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	PANTHER
NV2t017170002.1	cellular_component	GO:0000347	THO complex	"The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]	OMA
NV2t017170002.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t017170003.1	biological_process	GO:0032786	positive regulation of DNA-templated transcription, elongation	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH]	PANTHER
NV2t017171001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017171001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t017172001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017172001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017173001.1	biological_process	GO:0070125	mitochondrial translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]	PANTHER
NV2t017173001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017173002.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t017173002.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t017173002.1	biological_process	GO:0070125	mitochondrial translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]	PANTHER
NV2t017173002.1	cellular_component	GO:0042645	mitochondrial nucleoid	"The region of a mitochondrion to which the DNA is confined." [GOC:jl]	OMA
NV2t017173002.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t017173002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t017173002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017173002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t017174001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t017175001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	InterPro
NV2t017175001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t017175001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017175001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017175001.1	cellular_component	GO:0072487	MSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]	OMA
NV2t017175001.1	cellular_component	GO:0072487	MSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]	PANTHER
NV2t017175001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t017175001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t017175001.1	molecular_function	GO:0046972	histone H4K16 acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4." [EC:2.3.1.48]	OMA
NV2t017176002.1	biological_process	GO:0007286	spermatid development	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]	OMA
NV2t017180001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017180001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017180001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017180002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017180002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017180003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017180004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017180005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017180005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017180006.1	biological_process	GO:0000380	alternative mRNA splicing, via spliceosome	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]	OMA
NV2t017180006.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t017180006.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	OMA
NV2t017180006.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t017180006.1	biological_process	GO:0030856	regulation of epithelial cell differentiation	"Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]	OMA
NV2t017180006.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t017180006.1	biological_process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	"Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t017180006.1	biological_process	GO:0050678	regulation of epithelial cell proliferation	"Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]	OMA
NV2t017180006.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t017180006.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t017180006.1	biological_process	GO:0061041	regulation of wound healing	"Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph]	OMA
NV2t017180006.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t017180006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017180006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017180006.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t017180006.1	molecular_function	GO:0036002	pre-mRNA binding	"Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]	OMA
NV2t017181001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017181001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017182002.1	molecular_function	GO:0016846	carbon-sulfur lyase activity	"Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]	InterPro
NV2t017182002.1	molecular_function	GO:0016846	carbon-sulfur lyase activity	"Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]	OMA
NV2t017185001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017185001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017185001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017186001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t017186001.1	biological_process	GO:0031116	positive regulation of microtubule polymerization	"Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah]	OMA
NV2t017186001.1	biological_process	GO:1901673	regulation of mitotic spindle assembly	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]	OMA
NV2t017186001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017186001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017186001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017186001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t017186001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t017186001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017186001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t017186001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t017186001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t017186001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t017187001.1	biological_process	GO:0006275	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	InterPro
NV2t017187001.1	biological_process	GO:0006275	regulation of DNA replication	"Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]	OMA
NV2t017187001.1	biological_process	GO:0045786	negative regulation of cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t017196001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017196001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017197001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017197001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017197001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017197001.1	molecular_function	GO:0015276	ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017198001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t017199001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017199001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017199001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t017200001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017200001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017200001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t017205001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017205002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017205002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017205002.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t017206001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017206001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017206001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t017207001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017207001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017207001.1	cellular_component	GO:0043189	H4/H2A histone acetyltransferase complex	"A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah, GOC:rb]	InterPro
NV2t017207001.1	cellular_component	GO:0043189	H4/H2A histone acetyltransferase complex	"A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah, GOC:rb]	OMA
NV2t017208001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017208001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017210001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017210001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017210001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t017210001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t017213001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t017213001.1	biological_process	GO:0045214	sarcomere organization	"The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]	OMA
NV2t017213001.1	biological_process	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	OMA
NV2t017213001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017213001.1	cellular_component	GO:0030018	Z disc	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]	OMA
NV2t017213001.1	molecular_function	GO:0008307	structural constituent of muscle	"The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]	OMA
NV2t017213001.1	molecular_function	GO:0042805	actinin binding	"Binding to actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732]	OMA
NV2t017214001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t017215001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t017215001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t017215001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t017215001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t017216001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017216001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017216002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017216002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017216003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017216003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017216004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017216004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017216005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017216005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017216006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017216006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017216007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017217001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017217001.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t017217001.1	biological_process	GO:0035608	protein deglutamylation	"The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation." [GOC:sp, PMID:21074048]	InterPro
NV2t017217001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t017217001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017217001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017220001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t017220001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t017220001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t017220001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t017220001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t017220001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t017220001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t017220002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t017220002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t017220002.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t017221001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017221001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t017221001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017221001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t017221001.1	molecular_function	GO:0022843	voltage-gated monoatomic cation channel activity	"Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017223001.1	biological_process	GO:0070131	positive regulation of mitochondrial translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]	PANTHER
NV2t017224001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t017224001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	OMA
NV2t017224001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t017224001.1	biological_process	GO:0030388	fructose 1,6-bisphosphate metabolic process	"The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732]	PANTHER
NV2t017224001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t017224001.1	biological_process	GO:0042592	homeostatic process	"Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]	OMA
NV2t017224001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017224001.1	cellular_component	GO:0031674	I band	"A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131]	OMA
NV2t017224001.1	molecular_function	GO:0004332	fructose-bisphosphate aldolase activity	"Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate." [EC:4.1.2.13]	OMA
NV2t017225001.1	biological_process	GO:0001516	prostaglandin biosynthetic process	"The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai]	OMA
NV2t017225001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t017225001.1	biological_process	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t017225001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t017225001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t017225001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t017225001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t017225001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t017225001.1	biological_process	GO:0010739	positive regulation of protein kinase A signaling	"Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t017225001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t017225001.1	biological_process	GO:0031324	negative regulation of cellular metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t017225001.1	biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	OMA
NV2t017225001.1	biological_process	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]	OMA
NV2t017225001.1	biological_process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]	OMA
NV2t017225001.1	biological_process	GO:0050922	negative regulation of chemotaxis	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]	OMA
NV2t017225001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t017225001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t017225001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	OMA
NV2t017225001.1	biological_process	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541]	OMA
NV2t017225001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t017225001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017225001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017225001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017225001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t017225001.1	molecular_function	GO:0004167	dopachrome isomerase activity	"Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13041]	OMA
NV2t017225001.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t017225001.1	molecular_function	GO:0005126	cytokine receptor binding	"Binding to a cytokine receptor." [GOC:mah, GOC:vw]	OMA
NV2t017225001.1	molecular_function	GO:0042056	chemoattractant activity	"Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t017225001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t017225001.1	molecular_function	GO:0050178	phenylpyruvate tautomerase activity	"Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [RHEA:17097]	PANTHER
NV2t017226001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	PANTHER
NV2t017226001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t017226001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017227001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017227001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017227001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017227001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t017227002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017227002.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t017227003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017227003.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t017227004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017227004.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t017228001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t017228001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t017228001.1	biological_process	GO:0010795	regulation of ubiquinone biosynthetic process	"Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb]	OMA
NV2t017228001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t017228001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t017228002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t017229001.1	biological_process	GO:0006622	protein targeting to lysosome	"The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators]	OMA
NV2t017229001.1	biological_process	GO:0006898	receptor-mediated endocytosis	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]	OMA
NV2t017229001.1	biological_process	GO:0010976	positive regulation of neuron projection development	"Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t017229001.1	biological_process	GO:0015914	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	OMA
NV2t017229001.1	biological_process	GO:0043471	obsolete regulation of cellular carbohydrate catabolic process	"OBSOLETE. Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl]	OMA
NV2t017229001.1	biological_process	GO:0051336	regulation of hydrolase activity	"Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai]	OMA
NV2t017229001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t017229001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017229001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017229001.1	cellular_component	GO:0030666	endocytic vesicle membrane	"The lipid bilayer surrounding an endocytic vesicle." [GOC:mah]	OMA
NV2t017229001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t017229001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t017229001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t017229001.1	molecular_function	GO:0015485	cholesterol binding	"Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]	OMA
NV2t017229001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t017229001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t017229001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t017229001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t017230001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t017230001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t017230001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017230001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017230001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t017230001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t017230001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017230001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t017230001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017230001.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	OMA
NV2t017230001.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	PANTHER
NV2t017230001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t017230001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t017231001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017233001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017234001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017234001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017234001.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t017234002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017234002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017234002.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t017234003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017234003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017234003.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t017234004.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017234004.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017234004.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t017234005.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017234005.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017234005.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	PANTHER
NV2t017235001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t017235001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017235001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t017235001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017235001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017235001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t017235001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017235001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017236001.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	InterPro
NV2t017236001.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	OMA
NV2t017236001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t017236001.1	molecular_function	GO:0008135	translation factor activity, RNA binding	"Functions during translation by binding to RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw]	OMA
NV2t017237001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t017237001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017237001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t017237001.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t017237001.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t017237001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017237001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t017237001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t017237001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017240001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t017240001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t017240001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017240001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	InterPro
NV2t017240001.1	molecular_function	GO:0036374	glutathione hydrolase activity	"Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]	OMA
NV2t017242001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017242001.1	biological_process	GO:0006990	obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	"OBSOLETE. The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763]	PANTHER
NV2t017242001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t017243001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017243001.1	molecular_function	GO:0042799	histone H4K20 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein." [PMID:12086618]	InterPro
NV2t017243001.1	molecular_function	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	PANTHER
NV2t017244001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	PANTHER
NV2t017244002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	PANTHER
NV2t017244003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t017244003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t017244003.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	PANTHER
NV2t017244004.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t017244004.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	PANTHER
NV2t017245001.1	biological_process	GO:0071025	RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs." [GOC:dgf, GOC:krc, PMID:18644474]	InterPro
NV2t017245002.1	biological_process	GO:0071025	RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs." [GOC:dgf, GOC:krc, PMID:18644474]	InterPro
NV2t017246001.1	biological_process	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	InterPro
NV2t017246001.1	biological_process	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	OMA
NV2t017246001.1	biological_process	GO:0006222	UMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732]	OMA
NV2t017246001.1	biological_process	GO:0006541	glutamine metabolic process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	InterPro
NV2t017246001.1	biological_process	GO:0006541	glutamine metabolic process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	OMA
NV2t017246001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017246001.1	biological_process	GO:0009185	ribonucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t017246001.1	biological_process	GO:0009209	pyrimidine ribonucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t017246001.1	biological_process	GO:0019240	citrulline biosynthetic process	"The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732]	PANTHER
NV2t017246001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t017246001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t017246001.1	biological_process	GO:1901607	alpha-amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t017246001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017246001.1	cellular_component	GO:0016363	nuclear matrix	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]	OMA
NV2t017246001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t017246001.1	cellular_component	GO:0043195	terminal bouton	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]	OMA
NV2t017246001.1	molecular_function	GO:0004070	aspartate carbamoyltransferase activity	"Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate." [EC:2.1.3.2, RHEA:20013]	OMA
NV2t017246001.1	molecular_function	GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	"Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5, RHEA:18633]	OMA
NV2t017246001.1	molecular_function	GO:0004151	dihydroorotase activity	"Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+." [EC:3.5.2.3, RHEA:24296]	OMA
NV2t017246001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017246001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017246001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017246001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t017246001.1	molecular_function	GO:0016743	carboxyl- or carbamoyltransferase activity	"Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t017246001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t017246001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t017246001.1	molecular_function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	InterPro
NV2t017246001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t017246001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t017246001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t017248001.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	InterPro
NV2t017250001.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	InterPro
NV2t017253001.1	biological_process	GO:0045104	intermediate filament cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]	InterPro
NV2t017253001.1	biological_process	GO:0045104	intermediate filament cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]	OMA
NV2t017253001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017253001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017253001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017253001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017253001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t017254001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017255001.1	biological_process	GO:0045104	intermediate filament cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]	OMA
NV2t017255001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017256001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017256001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017260001.1	biological_process	GO:0045104	intermediate filament cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]	InterPro
NV2t017260001.1	biological_process	GO:0045104	intermediate filament cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]	OMA
NV2t017261001.1	biological_process	GO:0045104	intermediate filament cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]	InterPro
NV2t017261002.1	biological_process	GO:0045104	intermediate filament cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]	InterPro
NV2t017264001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t017264001.1	biological_process	GO:0032048	cardiolipin metabolic process	"The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah]	OMA
NV2t017264001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t017264001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t017264001.1	cellular_component	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex	"A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]	PANTHER
NV2t017264001.1	cellular_component	GO:0042645	mitochondrial nucleoid	"The region of a mitochondrion to which the DNA is confined." [GOC:jl]	OMA
NV2t017264001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t017264001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t017264001.1	molecular_function	GO:0004300	enoyl-CoA hydratase activity	"Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17]	OMA
NV2t017264001.1	molecular_function	GO:0016408	C-acyltransferase activity	"Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]	OMA
NV2t017264001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t017264001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t017264001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t017264001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t017264001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t017264002.1	cellular_component	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex	"A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]	InterPro
NV2t017264002.1	cellular_component	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex	"A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]	PANTHER
NV2t017264002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t017264002.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t017264003.1	cellular_component	GO:0016507	mitochondrial fatty acid beta-oxidation multienzyme complex	"A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]	PANTHER
NV2t017264003.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t017265001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017265001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t017268002.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t017269001.1	biological_process	GO:0060700	regulation of ribonuclease activity	"Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]	PANTHER
NV2t017269001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017270001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017272001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t017272001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t017272001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t017272001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017272001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t017272001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t017272001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t017273001.1	biological_process	GO:0006646	phosphatidylethanolamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]	PANTHER
NV2t017273001.1	biological_process	GO:0046337	phosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732]	OMA
NV2t017273001.1	biological_process	GO:0046474	glycerophospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t017273001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017273001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t017273001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	InterPro
NV2t017273001.1	molecular_function	GO:0017169	CDP-alcohol phosphatidyltransferase activity	"Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai]	OMA
NV2t017274001.1	biological_process	GO:0006473	protein acetylation	"The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t017274001.1	biological_process	GO:0034088	maintenance of mitotic sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]	OMA
NV2t017274001.1	biological_process	GO:0034088	maintenance of mitotic sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]	PANTHER
NV2t017274001.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	OMA
NV2t017274001.1	biological_process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	"Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]	OMA
NV2t017274001.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	OMA
NV2t017274001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t017274001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t017274001.1	cellular_component	GO:0031390	Ctf18 RFC-like complex	"A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842]	InterPro
NV2t017274001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t017274001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t017275001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017275001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t017275002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017275003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017278001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	InterPro
NV2t017278001.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	OMA
NV2t017278001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	OMA
NV2t017278001.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	PANTHER
NV2t017278001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t017278002.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	InterPro
NV2t017278002.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	PANTHER
NV2t017278003.1	biological_process	GO:0007099	centriole replication	"The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124]	InterPro
NV2t017278003.1	biological_process	GO:0071539	protein localization to centrosome	"A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]	PANTHER
NV2t017280001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017280001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017280002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017280002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017280002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017282001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t017282001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017282001.1	biological_process	GO:0035065	obsolete regulation of histone acetylation	"OBSOLETE. Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]	InterPro
NV2t017282001.1	biological_process	GO:0035066	obsolete positive regulation of histone acetylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]	OMA
NV2t017282001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017282001.1	cellular_component	GO:0070461	SAGA-type complex	"A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]	OMA
NV2t017282001.1	cellular_component	GO:0070461	SAGA-type complex	"A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]	PANTHER
NV2t017282001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t017282001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t017282001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017282001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017282001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017288001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t017288001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017292001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017293001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t017293001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t017293001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t017293001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t017293001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t017295001.1	cellular_component	GO:0071556	obsolete integral component of lumenal side of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t017295001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t017295001.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017297001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017297001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017297001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017298001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017298001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017299001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	InterPro
NV2t017299001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t017299001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t017299001.1	biological_process	GO:0051598	meiotic recombination checkpoint signaling	"A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes." [PMID:14718568]	OMA
NV2t017299001.1	biological_process	GO:0071479	cellular response to ionizing radiation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]	OMA
NV2t017299001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t017299001.1	cellular_component	GO:0030896	checkpoint clamp complex	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]	OMA
NV2t017299001.1	cellular_component	GO:0030896	checkpoint clamp complex	"Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]	PANTHER
NV2t017299001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017299001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t017300001.1	molecular_function	GO:0047372	acylglycerol lipase activity	"Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]	PANTHER
NV2t017303001.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t017303002.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t017303003.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t017303004.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t017303005.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t017303006.1	molecular_function	GO:0047372	acylglycerol lipase activity	"Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]	PANTHER
NV2t017303007.1	molecular_function	GO:0047372	acylglycerol lipase activity	"Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]	PANTHER
NV2t017304001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t017304001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017304001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t017304001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017304002.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t017304002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017306001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017306001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t017306001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017311001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t017311001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t017311001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017313001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t017313001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	PANTHER
NV2t017313001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t017313001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t017313001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t017313001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017313001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017313001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017313001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017318001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017318001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017318001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017319001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t017319001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017319001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t017319001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t017320001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017320001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t017320002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017320002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t017320003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017320003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t017320003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017320004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017320004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t017320004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017320005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017320005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t017320005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017320006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017320006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t017320007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017320007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t017320007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017320008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017320008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t017320008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t017320008.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t017320008.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017320008.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017321003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017321004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017321005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017331001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017331002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017331003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017331004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017331005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017331006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017331007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017332001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017332001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t017332001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017332001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017332002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017332002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t017332002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017332002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017332003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017332003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017332003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t017332003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t017332003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017332003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017332003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017335001.1	biological_process	GO:0002520	immune system development	"The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]	OMA
NV2t017335001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t017335001.1	biological_process	GO:0010467	gene expression	"The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950]	OMA
NV2t017335001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t017335001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t017335001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017335001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017335001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t017335001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t017335001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t017335001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t017335001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t017336001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t017336001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017336001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017336001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t017336001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017340001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	PANTHER
NV2t017341001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t017341001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017341001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017341001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t017342001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t017342001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t017342001.1	biological_process	GO:0031106	septin ring organization	"Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah]	PANTHER
NV2t017345001.1	biological_process	GO:0006650	glycerophospholipid metabolic process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t017345001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t017345001.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t017345001.1	biological_process	GO:0046503	glycerolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t017345001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017345001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017345001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t017345001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	OMA
NV2t017345002.1	biological_process	GO:0046475	glycerophospholipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t017348001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t017348001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t017348001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017348001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t017348001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t017348001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017348001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t017348001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t017348001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t017348001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t017349001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017350001.1	biological_process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	"Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation." [GOC:BHF]	PANTHER
NV2t017350001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017356001.1	biological_process	GO:0000003	obsolete reproduction	"OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732]	OMA
NV2t017356001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t017356001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017356001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t017356001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t017356001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t017356001.1	cellular_component	GO:0017053	transcription repressor complex	"A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]	OMA
NV2t017356001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t017357001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017357001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017357001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017357001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t017357002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017357002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017360001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017360001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t017360001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	InterPro
NV2t017360001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t017360001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017360001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t017362001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t017362001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017362001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t017365001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t017365001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t017365001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017365001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017365001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t017365001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t017365001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t017367001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t017367001.1	biological_process	GO:0110032	positive regulation of G2/MI transition of meiotic cell cycle	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408]	PANTHER
NV2t017367001.1	biological_process	GO:1902751	positive regulation of cell cycle G2/M phase transition	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	InterPro
NV2t017367001.1	biological_process	GO:1902751	positive regulation of cell cycle G2/M phase transition	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	OMA
NV2t017367001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t017368001.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	PANTHER
NV2t017368001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017368001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017368002.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	PANTHER
NV2t017368002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017368002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017368003.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	PANTHER
NV2t017368003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017368003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017368004.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	PANTHER
NV2t017368004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017368004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017368005.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	PANTHER
NV2t017368005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017368005.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017368006.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	PANTHER
NV2t017368006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017368006.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017368007.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	PANTHER
NV2t017368007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017368007.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017372001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t017372001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017372001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t017372001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017372001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017372001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t017374001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017374002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017374002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017374003.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017374004.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t017374004.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017374004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017374004.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t017374005.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017374006.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017374007.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017374007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017377001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t017377001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t017377001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t017377001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t017379001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017381001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017383001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017396001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t017404001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t017404001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017404001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t017404001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t017404001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017404001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	OMA
NV2t017404002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t017405001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t017405001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t017405001.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	OMA
NV2t017405001.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t017405001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t017405001.1	biological_process	GO:1904515	positive regulation of TORC2 signaling	"Any process that activates or increases the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25590601]	OMA
NV2t017405001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t017405001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017405001.1	cellular_component	GO:0031931	TORC1 complex	"A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t017405001.1	cellular_component	GO:0031932	TORC2 complex	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t017405001.1	cellular_component	GO:0034399	nuclear periphery	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]	OMA
NV2t017405001.1	cellular_component	GO:0070209	obsolete ASTRA complex	"OBSOLETE. A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720, PMID:22505622]	PANTHER
NV2t017405001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t017405001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t017405001.1	molecular_function	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	OMA
NV2t017405001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t017405001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t017405002.1	cellular_component	GO:0070209	obsolete ASTRA complex	"OBSOLETE. A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720, PMID:22505622]	PANTHER
NV2t017407001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017407001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017407002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017407002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017409001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017409001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017409001.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	PANTHER
NV2t017409002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017409002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017409002.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	PANTHER
NV2t017409003.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017409003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017409003.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	PANTHER
NV2t017409005.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017409005.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017409005.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	PANTHER
NV2t017410001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017410001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017410001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t017410001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t017410001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t017410001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t017410001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017410002.1	cellular_component	GO:1990316	Atg1/ULK1 kinase complex	"A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]	InterPro
NV2t017410002.1	cellular_component	GO:1990316	Atg1/ULK1 kinase complex	"A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]	PANTHER
NV2t017410003.1	cellular_component	GO:1990316	Atg1/ULK1 kinase complex	"A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]	InterPro
NV2t017410003.1	cellular_component	GO:1990316	Atg1/ULK1 kinase complex	"A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]	PANTHER
NV2t017411001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t017411001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017415001.1	biological_process	GO:2000641	regulation of early endosome to late endosome transport	"Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	PANTHER
NV2t017416001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017416001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t017416001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017417002.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t017420001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017423001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017423001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t017423001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017424001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t017424001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t017424001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017424001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t017427001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t017427001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t017427001.1	biological_process	GO:2000641	regulation of early endosome to late endosome transport	"Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	OMA
NV2t017427001.1	biological_process	GO:2000641	regulation of early endosome to late endosome transport	"Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]	PANTHER
NV2t017427001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t017427001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t017427001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t017430001.1	biological_process	GO:0046530	photoreceptor cell differentiation	"The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732]	OMA
NV2t017430001.1	cellular_component	GO:0005902	microvillus	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]	OMA
NV2t017430001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t017430001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017430001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t017430001.1	cellular_component	GO:1903561	extracellular vesicle	"Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233]	OMA
NV2t017430001.1	molecular_function	GO:0015485	cholesterol binding	"Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]	OMA
NV2t017430002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017430003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017430004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017430005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017432001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017433001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t017433001.1	biological_process	GO:0006560	proline metabolic process	"The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t017433001.1	biological_process	GO:0006561	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	InterPro
NV2t017433001.1	biological_process	GO:0009084	glutamine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t017433001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017433001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t017433001.1	molecular_function	GO:0004349	glutamate 5-kinase activity	"Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+." [EC:2.7.2.11, RHEA:14877]	OMA
NV2t017433001.1	molecular_function	GO:0004350	glutamate-5-semialdehyde dehydrogenase activity	"Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH." [EC:1.2.1.41, RHEA:19541]	OMA
NV2t017433001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017433001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t017433001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017433001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t017433001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t017433003.1	biological_process	GO:0006561	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	InterPro
NV2t017433003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t017433003.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t017433003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017433003.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t017433004.1	biological_process	GO:0006561	proline biosynthetic process	"The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732]	InterPro
NV2t017433004.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t017433004.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t017433004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017433004.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t017436001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	PANTHER
NV2t017438001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t017438001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t017439001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017439001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017439001.1	biological_process	GO:0032388	positive regulation of intracellular transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t017439001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t017439001.1	biological_process	GO:0060628	regulation of ER to Golgi vesicle-mediated transport	"Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb]	OMA
NV2t017439001.1	biological_process	GO:0090158	endoplasmic reticulum membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t017439001.1	biological_process	GO:1902117	positive regulation of organelle assembly	"Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie]	OMA
NV2t017439001.1	biological_process	GO:1903358	regulation of Golgi organization	"Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]	OMA
NV2t017439001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t017439001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t017439001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t017439001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t017439001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017439002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017439002.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t017442001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017442001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017442001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017445001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t017448001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t017448001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t017448001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017448001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017448001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017448001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017448002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017452001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t017452001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t017452001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017452001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017452001.1	molecular_function	GO:0030295	protein kinase activator activity	"Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t017452001.1	molecular_function	GO:0030295	protein kinase activator activity	"Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	PANTHER
NV2t017453001.1	molecular_function	GO:0080019	alcohol-forming very long-chain fatty acyl-CoA reductase activity	"Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:16980563]	PANTHER
NV2t017453002.1	biological_process	GO:0035336	long-chain fatty-acyl-CoA metabolic process	"The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]	OMA
NV2t017453002.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t017453002.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t017453002.1	molecular_function	GO:0080019	alcohol-forming very long-chain fatty acyl-CoA reductase activity	"Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:16980563]	PANTHER
NV2t017453003.1	molecular_function	GO:0080019	alcohol-forming very long-chain fatty acyl-CoA reductase activity	"Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:16980563]	PANTHER
NV2t017454001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017454001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t017454001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t017454001.1	biological_process	GO:0007409	axonogenesis	"De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]	OMA
NV2t017454001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t017454001.1	biological_process	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t017454001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t017454001.1	biological_process	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	OMA
NV2t017454001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t017454001.1	biological_process	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t017454001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t017454001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017454001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t017454001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t017454001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t017454001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t017454001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017454001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017454001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017454001.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	OMA
NV2t017454001.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t017454002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017454002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017454002.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t017456001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t017456001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t017456001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t017456001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t017456001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t017456001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017456001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t017456001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017458001.1	biological_process	GO:0019695	choline metabolic process	"The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]	OMA
NV2t017458001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t017458001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t017458001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t017458001.1	molecular_function	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t017458001.1	molecular_function	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t017458001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t017458001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t017458002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t017460001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t017460001.1	biological_process	GO:0007369	gastrulation	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]	OMA
NV2t017460001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t017460001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	OMA
NV2t017460001.1	biological_process	GO:0090504	epiboly	"The expansion of one cell sheet over other cells or yolk." [GOC:dph, GOC:tb]	OMA
NV2t017460001.1	biological_process	GO:1902412	regulation of mitotic cytokinesis	"Any process that modulates the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t017460001.1	cellular_component	GO:0000235	astral microtubule	"Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]	OMA
NV2t017460001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t017460001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t017460001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t017463001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t017463001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t017463001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017463001.1	cellular_component	GO:0070209	obsolete ASTRA complex	"OBSOLETE. A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720, PMID:22505622]	PANTHER
NV2t017463001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t017464001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t017464001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017465001.1	biological_process	GO:0007062	sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194]	OMA
NV2t017465001.1	biological_process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	"The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651]	PANTHER
NV2t017465001.1	cellular_component	GO:0008278	cohesin complex	"A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]	OMA
NV2t017465001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017466001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t017468001.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t017468002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t017468002.1	biological_process	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t017468002.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t017468002.1	biological_process	GO:0042593	glucose homeostasis	"Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]	OMA
NV2t017468002.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t017468002.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t017468002.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	InterPro
NV2t017468002.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	OMA
NV2t017468002.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t017468002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017468002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t017468003.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t017469001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t017469001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t017469001.1	biological_process	GO:0018230	peptidyl-L-cysteine S-palmitoylation	"The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106]	PANTHER
NV2t017469001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t017469001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t017469001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t017469002.1	biological_process	GO:0018230	peptidyl-L-cysteine S-palmitoylation	"The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106]	PANTHER
NV2t017471001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t017471001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017474001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t017474001.1	biological_process	GO:0000725	recombinational repair	"A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh]	OMA
NV2t017474001.1	biological_process	GO:0071479	cellular response to ionizing radiation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]	InterPro
NV2t017474001.1	biological_process	GO:0071479	cellular response to ionizing radiation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]	OMA
NV2t017474001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017474001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t017475001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t017475002.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t017475003.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t017475004.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t017476001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t017476001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t017476001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017476001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t017477001.1	molecular_function	GO:0051920	peroxiredoxin activity	"Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]	InterPro
NV2t017480001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t017480001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017480001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t017481001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	InterPro
NV2t017481001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t017481001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t017484001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017484001.1	cellular_component	GO:0010369	chromocenter	"A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888]	OMA
NV2t017484001.1	cellular_component	GO:0010369	chromocenter	"A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888]	PANTHER
NV2t017484001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t017485001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t017485001.1	molecular_function	GO:0098621	O-phosphoseryl-tRNA(Sec) selenium transferase activity	"Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid." [PMID:17142313, PMID:19608919, RHEA:25041]	InterPro
NV2t017486001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017487001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017488001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017488001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017488001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t017488001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017489001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t017489001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t017489001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017489001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017491001.1	biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]	PANTHER
NV2t017492001.1	biological_process	GO:0002183	cytoplasmic translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]	OMA
NV2t017492001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t017492001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t017492001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	PANTHER
NV2t017492001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t017492001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t017493001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017493001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t017493001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t017494001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017494001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017494001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t017494001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t017494001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t017494001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t017494001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017495001.1	biological_process	GO:0007274	neuromuscular synaptic transmission	"The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]	PANTHER
NV2t017495001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017495002.1	biological_process	GO:0007274	neuromuscular synaptic transmission	"The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]	PANTHER
NV2t017495002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017495003.1	biological_process	GO:0007274	neuromuscular synaptic transmission	"The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]	PANTHER
NV2t017495003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017495004.1	biological_process	GO:0007274	neuromuscular synaptic transmission	"The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435]	PANTHER
NV2t017495004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017495007.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	InterPro
NV2t017495008.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	InterPro
NV2t017495011.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	InterPro
NV2t017495012.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	InterPro
NV2t017498001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t017498001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t017498001.1	biological_process	GO:0097345	mitochondrial outer membrane permeabilization	"The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309]	PANTHER
NV2t017498001.1	cellular_component	GO:0005740	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	OMA
NV2t017499001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017499001.1	biological_process	GO:0140300	serine import into mitochondrion	"The process in which serine is transported from the cytosol into the mitochondrial matrix." [PMID:30442778]	OMA
NV2t017499001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	PANTHER
NV2t017499001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t017499001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t017499001.1	molecular_function	GO:0015075	monoatomic ion transmembrane transporter activity	"Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017499001.1	molecular_function	GO:0022889	obsolete serine transmembrane transporter activity	"OBSOLETE. Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729, RHEA:35031]	OMA
NV2t017501001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t017501001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t017502001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t017502001.1	cellular_component	GO:0033176	proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t017502001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t017504001.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	PANTHER
NV2t017504001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t017504001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t017504001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t017504001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t017505001.1	cellular_component	GO:0016593	Cdc73/Paf1 complex	"A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]	PANTHER
NV2t017505001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017506001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t017506001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t017506001.1	biological_process	GO:0070125	mitochondrial translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]	PANTHER
NV2t017506001.1	biological_process	GO:0070129	regulation of mitochondrial translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]	OMA
NV2t017506001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t017506001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t017506001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017507001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017507001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017507001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t017507002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017507002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017507003.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t017507005.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t017507006.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t017508001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t017508001.1	biological_process	GO:0045324	late endosome to vacuole transport	"The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]	PANTHER
NV2t017508002.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t017508002.1	biological_process	GO:0045324	late endosome to vacuole transport	"The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]	PANTHER
NV2t017509001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t017509001.1	biological_process	GO:0009067	aspartate family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t017509001.1	biological_process	GO:0043650	dicarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t017509001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017509001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t017509001.1	molecular_function	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	"Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1]	OMA
NV2t017509001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t017509001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017509001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t017509002.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t017509002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017509003.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	InterPro
NV2t017509003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017511001.1	biological_process	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	OMA
NV2t017511001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t017511001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t017511001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t017511001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	OMA
NV2t017511001.1	biological_process	GO:0070861	regulation of protein exit from endoplasmic reticulum	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017511001.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	OMA
NV2t017511001.1	biological_process	GO:0090317	negative regulation of intracellular protein transport	"Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t017511001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017511001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t017511001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t017511001.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	OMA
NV2t017515001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t017515001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t017515001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t017515001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t017515001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t017515001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t017515001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017516001.1	biological_process	GO:0031167	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	InterPro
NV2t017516001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t017516001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017516001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t017516001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017516001.1	molecular_function	GO:0008988	rRNA (adenine-N6-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [RHEA:58728]	OMA
NV2t017517001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017519001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017531001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017532001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t017532001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t017532001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017532001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017532001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017533001.1	biological_process	GO:0000272	polysaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480]	InterPro
NV2t017533001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t017533001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017534001.1	biological_process	GO:0010458	exit from mitosis	"The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]	OMA
NV2t017534001.1	cellular_component	GO:0000159	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	OMA
NV2t017534001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017534001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017534001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	InterPro
NV2t017534001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t017534001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t017535001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017535001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017536001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017536001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017536001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t017536001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017537001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017537001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017539001.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t017539001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017539002.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t017539002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017539003.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t017539003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017541001.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t017542001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	PANTHER
NV2t017543001.1	biological_process	GO:0097205	renal filtration	"A renal system process in which fluid circulating through the body is filtered through a barrier system." [GOC:pr, GOC:sart]	OMA
NV2t017543001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017543001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t017543001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017543001.1	molecular_function	GO:0005034	osmosensor activity	"Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb]	OMA
NV2t017543001.1	molecular_function	GO:0005227	calcium-activated cation channel activity	"Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	OMA
NV2t017543001.1	molecular_function	GO:0005261	monoatomic cation channel activity	"Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t017543001.1	molecular_function	GO:0022890	inorganic cation transmembrane transporter activity	"Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017545001.1	biological_process	GO:0043551	obsolete regulation of phosphatidylinositol 3-kinase activity	"OBSOLETE. Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf]	OMA
NV2t017545001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	OMA
NV2t017545001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017545001.1	molecular_function	GO:0141039	phosphatidylinositol 3-kinase inhibitor activity	"Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K)." [PMID:31686003]	InterPro
NV2t017547001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017547001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017547001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t017547001.1	molecular_function	GO:0061775	cohesin loader activity	"Facilitating a conformational change to load a cohesin complex around sister chromatids." [GOC:vw, PMID:26687354]	PANTHER
NV2t017548001.1	biological_process	GO:0046599	regulation of centriole replication	"Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]	OMA
NV2t017548001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t017548001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t017548001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017548001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t017549001.1	molecular_function	GO:0004065	arylsulfatase activity	"Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1]	PANTHER
NV2t017549001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t017552001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t017552001.1	molecular_function	GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	"Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [RHEA:21284]	OMA
NV2t017552001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017552002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t017552002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017553001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t017553001.1	molecular_function	GO:0061775	cohesin loader activity	"Facilitating a conformational change to load a cohesin complex around sister chromatids." [GOC:vw, PMID:26687354]	PANTHER
NV2t017553002.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t017553002.1	molecular_function	GO:0061775	cohesin loader activity	"Facilitating a conformational change to load a cohesin complex around sister chromatids." [GOC:vw, PMID:26687354]	PANTHER
NV2t017554001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t017554002.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t017554003.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t017554004.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t017554004.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	OMA
NV2t017554004.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t017554004.1	molecular_function	GO:0008195	phosphatidate phosphatase activity	"Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [GOC:pr, PMID:25814022, RHEA:27429]	OMA
NV2t017554004.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t017554005.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	PANTHER
NV2t017555001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017555001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017556001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	OMA
NV2t017556001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	InterPro
NV2t017556001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t017556001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t017556001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t017556001.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	InterPro
NV2t017556001.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	OMA
NV2t017556001.1	cellular_component	GO:0000145	exocyst	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]	OMA
NV2t017556001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017556001.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t017556001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t017556002.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	InterPro
NV2t017556003.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	InterPro
NV2t017556003.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	InterPro
NV2t017556004.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	InterPro
NV2t017556004.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	InterPro
NV2t017556005.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	InterPro
NV2t017556005.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	InterPro
NV2t017557001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t017557002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t017557002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t017557006.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t017559001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t017559001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t017559001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t017559001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	InterPro
NV2t017559001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t017559001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017560001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017560001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017561001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017561001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017561001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t017561001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017561001.1	molecular_function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]	OMA
NV2t017561001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t017562001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t017565001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t017565001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017567001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t017570001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t017570001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t017570001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t017570001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t017570001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t017571001.1	molecular_function	GO:0004896	cytokine receptor activity	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]	OMA
NV2t017571001.1	molecular_function	GO:0030368	interleukin-17 receptor activity	"Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]	PANTHER
NV2t017571002.1	molecular_function	GO:0030368	interleukin-17 receptor activity	"Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]	PANTHER
NV2t017574001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017574002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017574003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017578001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t017578001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017578001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017578001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017578001.1	cellular_component	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t017578001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t017579001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017580001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t017580001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	InterPro
NV2t017580001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t017584001.1	biological_process	GO:0042407	cristae formation	"The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t017584001.1	cellular_component	GO:0061617	MICOS complex	"Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277]	PANTHER
NV2t017584001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t017585001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t017585001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t017585001.1	biological_process	GO:0097510	base-excision repair, AP site formation via deaminated base removal	"A base-excision repair, AP site formation process occurring via excision of a deaminated base." [GOC:al, PMID:18789404]	PANTHER
NV2t017585001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017585001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017585001.1	molecular_function	GO:0004844	uracil DNA N-glycosylase activity	"Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623]	OMA
NV2t017585001.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	InterPro
NV2t017585002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t017585002.1	biological_process	GO:0097510	base-excision repair, AP site formation via deaminated base removal	"A base-excision repair, AP site formation process occurring via excision of a deaminated base." [GOC:al, PMID:18789404]	PANTHER
NV2t017585002.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	InterPro
NV2t017586001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t017586001.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	InterPro
NV2t017586001.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t017586001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017587001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t017587001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	PANTHER
NV2t017587001.1	biological_process	GO:0006903	vesicle targeting	"The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]	OMA
NV2t017587001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t017587001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017587001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t017587001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t017587001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t017587001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017587001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t017587001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t017587001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t017587001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t017587002.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	PANTHER
NV2t017587002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017588001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t017588001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t017588001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017588001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t017588002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t017588002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t017588002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t017588002.1	molecular_function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	"Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate." [RHEA:14653]	OMA
NV2t017588002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017588002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t017588003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017591001.1	biological_process	GO:0006509	membrane protein ectodomain proteolysis	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]	PANTHER
NV2t017592001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t017592001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017592002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017592002.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t017592002.1	biological_process	GO:0009404	toxin metabolic process	"The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2]	OMA
NV2t017592002.1	biological_process	GO:0010518	positive regulation of phospholipase activity	"Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t017592002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t017592002.1	biological_process	GO:0034067	protein localization to Golgi apparatus	"A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]	OMA
NV2t017592002.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t017592002.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t017592002.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t017592002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t017592002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017592002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t017592002.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t017592002.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t017592003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t017592003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017592004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t017592004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017594001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t017594001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017594001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t017594001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t017594001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017594002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017594003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017594004.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017594005.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017594006.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017594007.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017594008.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017595001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t017595001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017595002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017595003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017596001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017597001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t017597001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t017597001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t017597001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t017597001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t017597001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t017597001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t017599001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017600001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017606001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t017606001.1	biological_process	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	OMA
NV2t017606001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017606001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t017606001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t017606001.1	cellular_component	GO:0097060	synaptic membrane	"A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104]	PANTHER
NV2t017606001.1	molecular_function	GO:0005080	protein kinase C binding	"Binding to protein kinase C." [GOC:jl]	OMA
NV2t017606001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017609001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t017609001.1	biological_process	GO:0010564	regulation of cell cycle process	"Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t017609001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t017609001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t017609001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017609001.1	biological_process	GO:0044419	biological process involved in interspecies interaction between organisms	"Any process evolved to enable an interaction with an organism of a different species." [GOC:cc]	OMA
NV2t017609001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t017609001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t017609001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t017609001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017609001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t017609001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t017609001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t017609001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017609001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017609001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017611001.1	biological_process	GO:0036353	obsolete histone H2A-K119 monoubiquitination	"OBSOLETE. The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022]	PANTHER
NV2t017612001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t017614001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017614001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t017614002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017614003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017616001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017617001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017617001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017617001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t017617002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017617002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017618001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017619001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t017619001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t017619001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017619001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017620001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017620001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t017620002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017620002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017620002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t017620003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017620003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t017620004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017620004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t017620005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017620005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t017620006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017620006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t017623001.1	biological_process	GO:0031032	actomyosin structure organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t017623001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t017623001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t017625001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t017625001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017625001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t017628001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t017628001.1	biological_process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf]	PANTHER
NV2t017628001.1	molecular_function	GO:0004869	cysteine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]	InterPro
NV2t017628001.1	molecular_function	GO:0004869	cysteine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase." [GOC:dph, GOC:tb]	OMA
NV2t017630001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t017630001.1	biological_process	GO:0031331	positive regulation of cellular catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t017630001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t017630001.1	biological_process	GO:0045806	negative regulation of endocytosis	"Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators]	OMA
NV2t017630001.1	biological_process	GO:0045862	positive regulation of proteolysis	"Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]	OMA
NV2t017630001.1	biological_process	GO:0051926	negative regulation of calcium ion transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t017630001.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	OMA
NV2t017630001.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	PANTHER
NV2t017630001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t017630001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017630001.1	molecular_function	GO:0005246	calcium channel regulator activity	"Modulates the activity of a calcium channel." [GOC:mah]	OMA
NV2t017630001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017630001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t017630001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	OMA
NV2t017630001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t017630001.1	molecular_function	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t017631001.1	biological_process	GO:0006520	amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]	OMA
NV2t017631001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t017631001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	OMA
NV2t017631001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	InterPro
NV2t017633001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t017633001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017634001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017634001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017634001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017639001.1	biological_process	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	OMA
NV2t017639001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t017639001.1	cellular_component	GO:0033176	proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t017639001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017639001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017639001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t017639001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	PANTHER
NV2t017641001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t017641001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t017641001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017641001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017641002.1	biological_process	GO:0097250	mitochondrial respirasome assembly	"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]	PANTHER
NV2t017642001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t017642001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t017642001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017642001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017642001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017642001.1	molecular_function	GO:0004984	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	OMA
NV2t017643001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t017643001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t017643001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t017643001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	PANTHER
NV2t017643001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t017643002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t017643002.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	PANTHER
NV2t017644001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017644001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017644003.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017644003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017644004.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t017644004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017644005.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017644005.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017644006.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017644006.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017644007.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017644007.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017645001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017645001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017645001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t017645001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t017646001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t017646001.1	biological_process	GO:0036065	fucosylation	"The covalent attachment of a fucosyl group to an acceptor molecule." [GOC:sart, PMID:19948734]	OMA
NV2t017646001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017646001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017646001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	OMA
NV2t017646001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t017650001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017650002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017651001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017651001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t017651002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017651002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017651002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t017651002.1	biological_process	GO:0007596	blood coagulation	"The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [PMID:30700128]	InterPro
NV2t017651002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t017651002.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t017652001.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	PANTHER
NV2t017652003.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	PANTHER
NV2t017652004.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	PANTHER
NV2t017653001.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	PANTHER
NV2t017654001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017654001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017654002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017654002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017654003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017654003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017654003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t017654003.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t017655001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017655001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t017655001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t017655001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t017655001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t017655001.1	biological_process	GO:0043407	negative regulation of MAP kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t017655001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017655001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017655001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t017655001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t017655001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017655001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017655001.1	molecular_function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	"Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase." [GOC:bf]	OMA
NV2t017657001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017659001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017663001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017667001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017667001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017667001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	PANTHER
NV2t017669001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017672001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017672001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t017672001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t017672002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017672002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t017673001.1	biological_process	GO:0006044	N-acetylglucosamine metabolic process	"The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732]	OMA
NV2t017673001.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t017673001.1	molecular_function	GO:0045127	N-acetylglucosamine kinase activity	"Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H+." [EC:2.7.1.59, RHEA:17417]	PANTHER
NV2t017674001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t017674001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017674002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017674003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017676001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t017676001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t017677001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017677001.1	molecular_function	GO:0042799	histone H4K20 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein." [PMID:12086618]	InterPro
NV2t017677001.1	molecular_function	GO:0042799	histone H4K20 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein." [PMID:12086618]	PANTHER
NV2t017677002.1	biological_process	GO:0034968	obsolete histone lysine methylation	"OBSOLETE. The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr]	OMA
NV2t017677002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017677002.1	molecular_function	GO:0042799	histone H4K20 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein." [PMID:12086618]	OMA
NV2t017677002.1	molecular_function	GO:0042799	histone H4K20 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein." [PMID:12086618]	PANTHER
NV2t017678001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t017678001.1	molecular_function	GO:0016151	nickel cation binding	"Binding to a nickel (Ni) cation." [GOC:ai]	InterPro
NV2t017678001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t017678002.1	molecular_function	GO:0016151	nickel cation binding	"Binding to a nickel (Ni) cation." [GOC:ai]	InterPro
NV2t017678003.1	molecular_function	GO:0016151	nickel cation binding	"Binding to a nickel (Ni) cation." [GOC:ai]	InterPro
NV2t017679001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t017679001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t017679001.1	biological_process	GO:0022600	digestive system process	"A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]	OMA
NV2t017679001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t017679001.1	biological_process	GO:0046717	acid secretion	"The controlled release of acid by a cell or a tissue." [GOC:ai]	OMA
NV2t017679001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t017679001.1	biological_process	GO:1903522	regulation of blood circulation	"Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969]	OMA
NV2t017679001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017679001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017679001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t017679001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t017679001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t017679001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017680001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017680001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017681001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017681001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017681001.1	molecular_function	GO:0032036	myosin heavy chain binding	"Binding to a heavy chain of a myosin complex." [GOC:mah]	PANTHER
NV2t017682001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	InterPro
NV2t017684001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017684001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t017684001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017684001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017685001.1	biological_process	GO:0006694	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	OMA
NV2t017685001.1	biological_process	GO:0008210	estrogen metabolic process	"The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]	OMA
NV2t017685001.1	biological_process	GO:0042446	hormone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t017685001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017685001.1	molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	"Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]	OMA
NV2t017685001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017685001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t017685001.1	molecular_function	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	"Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25033]	OMA
NV2t017687001.1	biological_process	GO:0006694	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	OMA
NV2t017687001.1	biological_process	GO:0008210	estrogen metabolic process	"The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]	OMA
NV2t017687001.1	biological_process	GO:0042446	hormone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t017687001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017687001.1	molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	"Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]	OMA
NV2t017687001.1	molecular_function	GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	"Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [RHEA:21284]	OMA
NV2t017687001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017687001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t017687001.1	molecular_function	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	"Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25033]	OMA
NV2t017692001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t017692001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t017692001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t017692001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t017692001.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t017692001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t017692001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t017692001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t017692001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t017692001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t017693001.1	biological_process	GO:0006576	biogenic amine metabolic process	"The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]	OMA
NV2t017693001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t017693001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t017693001.1	biological_process	GO:0034308	primary alcohol metabolic process	"The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]	OMA
NV2t017693001.1	biological_process	GO:0034311	diol metabolic process	"The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic." [GOC:curators]	OMA
NV2t017693001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t017693001.1	biological_process	GO:0046337	phosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732]	OMA
NV2t017693001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t017693001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t017693001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	PANTHER
NV2t017693001.1	molecular_function	GO:0017040	N-acylsphingosine amidohydrolase activity	"Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]	OMA
NV2t017693001.1	molecular_function	GO:0017064	fatty acid amide hydrolase activity	"Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid." [PMID:15952893]	InterPro
NV2t017693001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	OMA
NV2t017695001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017695001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017696001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	PANTHER
NV2t017696002.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	PANTHER
NV2t017696003.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t017696003.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t017696003.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	PANTHER
NV2t017696003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017696004.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	PANTHER
NV2t017698001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017700001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t017700001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t017700001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t017700001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017700001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017701001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t017701001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017701002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t017701002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017701003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t017701003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017701004.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t017701004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017702001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017702001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017703001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017703001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t017703001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	PANTHER
NV2t017703001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017703001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017703001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017703001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t017703001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t017704001.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	InterPro
NV2t017704001.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	OMA
NV2t017704001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t017704001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017704001.1	molecular_function	GO:0008135	translation factor activity, RNA binding	"Functions during translation by binding to RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw]	OMA
NV2t017705001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017707001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t017707001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017709001.1	biological_process	GO:0006559	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	OMA
NV2t017709001.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	OMA
NV2t017709001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017709001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017709001.1	molecular_function	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	OMA
NV2t017709001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t017709001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t017709001.1	molecular_function	GO:0070404	NADH binding	"Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t017709002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017709002.1	molecular_function	GO:0070404	NADH binding	"Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t017710001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	PANTHER
NV2t017710001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t017710001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017710001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017716001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t017716001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t017716001.1	biological_process	GO:0009826	unidimensional cell growth	"The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399]	OMA
NV2t017716001.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	OMA
NV2t017716001.1	biological_process	GO:0097320	plasma membrane tubulation	"A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103]	PANTHER
NV2t017716001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t017716001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017716001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t017716001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	InterPro
NV2t017717001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017717001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t017717001.1	molecular_function	GO:0016798	hydrolase activity, acting on glycosyl bonds	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]	InterPro
NV2t017717001.1	molecular_function	GO:0016798	hydrolase activity, acting on glycosyl bonds	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]	OMA
NV2t017718001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	PANTHER
NV2t017718001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017719001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017719001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t017719001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t017719001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t017719001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017719001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t017721001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t017722001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t017722001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t017722001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017722001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017722001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t017722001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t017722001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017722001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017723001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t017723001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017723001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017725001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t017726001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017728001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t017728001.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	PANTHER
NV2t017728001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t017728001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t017728001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	InterPro
NV2t017728001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t017729001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t017729001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t017729001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	PANTHER
NV2t017729001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017729001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t017729001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t017729001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t017729002.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	PANTHER
NV2t017730001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t017730001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t017730001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t017730002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t017730002.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t017732007.1	biological_process	GO:0006937	regulation of muscle contraction	"Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators]	OMA
NV2t017732007.1	cellular_component	GO:0005861	troponin complex	"A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194]	OMA
NV2t017733001.1	biological_process	GO:0030719	P granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]	OMA
NV2t017733001.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	OMA
NV2t017733001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t017733001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t017734001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t017734001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t017734001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t017734002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t017734002.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t017734003.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t017734003.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t017736001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t017736002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t017736003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t017736003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017736003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017736003.1	molecular_function	GO:0004427	inorganic diphosphate phosphatase activity	"Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate." [EC:3.6.1.1, RHEA:24576]	OMA
NV2t017736003.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t017736003.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t017736003.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t017737001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t017737001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t017737001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t017737001.1	cellular_component	GO:0030687	preribosome, large subunit precursor	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]	PANTHER
NV2t017737001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t017739001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t017739001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017739001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017739001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017740001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017741001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017742001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017743001.1	biological_process	GO:0006646	phosphatidylethanolamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]	PANTHER
NV2t017743001.1	biological_process	GO:0046337	phosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732]	OMA
NV2t017743001.1	biological_process	GO:0046474	glycerophospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t017743001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017743001.1	molecular_function	GO:0004305	ethanolamine kinase activity	"Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine." [EC:2.7.1.82, RHEA:13069]	OMA
NV2t017744001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t017744001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t017744001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t017744001.1	biological_process	GO:0009240	isopentenyl diphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t017744001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017744001.1	molecular_function	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3.-, GOC:mah]	OMA
NV2t017749001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t017751001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017751001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017751001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t017751001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t017751001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t017752001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017755001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017755001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017755001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t017755001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t017755002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017756001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017756001.1	molecular_function	GO:0015929	hexosaminidase activity	"Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544]	PANTHER
NV2t017759001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t017759001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t017759001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t017759001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t017759001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t017763001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t017763001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017763001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t017765001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t017765001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017765004.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t017765004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017765005.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t017765005.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t017765005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017765005.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017765005.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t017765005.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t017765005.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t017765005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017768001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t017768001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t017768001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017768001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t017768001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t017768001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t017768001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017768001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017769001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017769001.1	molecular_function	GO:0032036	myosin heavy chain binding	"Binding to a heavy chain of a myosin complex." [GOC:mah]	PANTHER
NV2t017771001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t017773001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t017773001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017773001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t017773001.1	cellular_component	GO:0098839	postsynaptic density membrane	"The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos]	OMA
NV2t017773001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017773002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017773002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t017773002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017774001.1	biological_process	GO:0002188	translation reinitiation	"A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792]	OMA
NV2t017774001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t017774001.1	biological_process	GO:0075522	IRES-dependent viral translational initiation	"Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation." [GOC:bf, GOC:jl, PMID:19632368, VZ:867]	OMA
NV2t017774001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017774001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t017774001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t017774001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t017774001.1	cellular_component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	"An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]	PANTHER
NV2t017774001.1	cellular_component	GO:0099080	supramolecular complex	"A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos]	OMA
NV2t017774001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t017774001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t017774001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t017774001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017774002.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t017774002.1	cellular_component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	"An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]	PANTHER
NV2t017774003.1	cellular_component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	"An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]	PANTHER
NV2t017774004.1	cellular_component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	"An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]	PANTHER
NV2t017775001.1	molecular_function	GO:0004065	arylsulfatase activity	"Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1]	PANTHER
NV2t017775002.1	molecular_function	GO:0004065	arylsulfatase activity	"Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1]	PANTHER
NV2t017775003.1	molecular_function	GO:0004065	arylsulfatase activity	"Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1]	PANTHER
NV2t017775003.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t017776001.1	molecular_function	GO:0004065	arylsulfatase activity	"Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1]	PANTHER
NV2t017776001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t017777001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017777001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t017777001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t017777001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t017777001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t017777001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t017777001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t017777001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t017778001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t017778001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017779001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t017780001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017780001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t017782001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017783001.1	biological_process	GO:0006646	phosphatidylethanolamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732]	PANTHER
NV2t017783001.1	biological_process	GO:0006657	CDP-choline pathway	"The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450]	OMA
NV2t017783001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017783001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t017783001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	InterPro
NV2t017783001.1	molecular_function	GO:0017169	CDP-alcohol phosphatidyltransferase activity	"Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai]	OMA
NV2t017790001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t017790001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t017790001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t017790001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t017790001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t017790001.1	molecular_function	GO:0070182	DNA polymerase binding	"Binding to a DNA polymerase." [GOC:BHF, GOC:mah]	OMA
NV2t017790001.1	molecular_function	GO:0070182	DNA polymerase binding	"Binding to a DNA polymerase." [GOC:BHF, GOC:mah]	PANTHER
NV2t017791001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t017791001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t017791001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t017791001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017791001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t017791001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t017792001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017792001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017792001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t017792001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t017793001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t017795001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017795001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t017795001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017796001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t017796001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t017796001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017796001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017799001.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	InterPro
NV2t017799001.1	biological_process	GO:0045947	negative regulation of translational initiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t017799001.1	molecular_function	GO:0000900	mRNA regulatory element binding translation repressor activity	"Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370]	OMA
NV2t017800002.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t017800003.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t017801001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017801001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017801001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t017801001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t017801001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t017801001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t017802001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t017802001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t017802001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t017802001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t017802001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t017802001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t017802001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t017803001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017803001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017803001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017803001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017803002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017803002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017804001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t017804001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017804001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t017804001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017804001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017804001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t017804001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017804001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017805001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t017805001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t017805001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t017805001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t017805001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t017805001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t017805001.1	cellular_component	GO:0005826	actomyosin contractile ring	"A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, GOC:vw, ISBN:0805319409, ISBN:0815316194, PMID:28914606]	OMA
NV2t017805001.1	cellular_component	GO:0016363	nuclear matrix	"The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]	OMA
NV2t017805001.1	cellular_component	GO:0034657	GID complex	"A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species." [PMID:12686616, PMID:18508925, PMID:35682545]	OMA
NV2t017805001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t017805001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017805001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t017805001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t017806001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017806001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017806001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017806001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t017807001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017807001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017807001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t017807001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t017807002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017807002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017807002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t017807003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017807003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017807003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t017807004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017807004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017807004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t017808001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017808001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017808001.1	biological_process	GO:0007596	blood coagulation	"The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [PMID:30700128]	InterPro
NV2t017808001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t017809001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	OMA
NV2t017809001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t017809001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t017809001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t017809001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017809002.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t017809002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017812001.1	biological_process	GO:0036444	calcium import into the mitochondrion	"A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix." [GOC:vw]	OMA
NV2t017812001.1	biological_process	GO:0051560	mitochondrial calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]	OMA
NV2t017812001.1	cellular_component	GO:0034704	calcium channel complex	"An ion channel complex through which calcium ions pass." [GOC:mah]	OMA
NV2t017812001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t017812001.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	InterPro
NV2t017812001.1	cellular_component	GO:1990246	uniplex complex	"A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]	PANTHER
NV2t017813001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017813001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017813001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t017813001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017817001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t017817001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017817001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017817001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t017817001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t017817001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t017817001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017818001.1	biological_process	GO:0006939	smooth muscle contraction	"A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732]	OMA
NV2t017818001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t017818001.1	biological_process	GO:0007623	circadian rhythm	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]	OMA
NV2t017818001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t017818001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t017818001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017818001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017818001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t017818001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t017818001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t017818001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017818002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017818002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017818003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017818003.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017818004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017818004.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017818005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017818005.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017818006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017818006.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017818007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017818007.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t017821001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t017821001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t017821001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017821001.1	cellular_component	GO:0005694	chromosome	"A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]	OMA
NV2t017821001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t017821001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017821001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t017821001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t017821001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t017821001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t017822001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t017822001.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t017822001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	PANTHER
NV2t017822001.1	biological_process	GO:0051641	cellular localization	"A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw]	OMA
NV2t017822001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017822001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t017822001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t017822001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t017822001.1	cellular_component	GO:0030427	site of polarized growth	"Any part of a cell where non-isotropic growth takes place." [GOC:mah]	OMA
NV2t017822001.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	OMA
NV2t017822001.1	cellular_component	GO:0042734	presynaptic membrane	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]	OMA
NV2t017822001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t017822001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t017822001.1	cellular_component	GO:0051286	cell tip	"The region at the end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah]	OMA
NV2t017822001.1	molecular_function	GO:0004430	1-phosphatidylinositol 4-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+." [EC:2.7.1.67, RHEA:19877]	OMA
NV2t017822001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017822001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t017823001.1	biological_process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	"Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation." [GOC:BHF]	PANTHER
NV2t017824001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017824001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t017824001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t017824001.1	biological_process	GO:0042994	cytoplasmic sequestering of transcription factor	"The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]	OMA
NV2t017824001.1	biological_process	GO:0042994	cytoplasmic sequestering of transcription factor	"The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]	PANTHER
NV2t017824001.1	biological_process	GO:0045879	negative regulation of smoothened signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]	OMA
NV2t017824001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t017824001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t017824001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017824001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017824001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t017824001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017824001.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	InterPro
NV2t017824001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t017826001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017827001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t017827001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017827002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017827003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t017828001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	InterPro
NV2t017829001.1	molecular_function	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah]	InterPro
NV2t017831001.1	biological_process	GO:0032481	positive regulation of type I interferon production	"Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]	InterPro
NV2t017831001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	PANTHER
NV2t017833001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t017833001.1	biological_process	GO:0002218	activation of innate immune response	"Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]	OMA
NV2t017833001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t017833001.1	biological_process	GO:0032481	positive regulation of type I interferon production	"Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]	InterPro
NV2t017833001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t017833001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	PANTHER
NV2t017834001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t017834001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t017834001.1	biological_process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	"Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd]	OMA
NV2t017834001.1	biological_process	GO:0002218	activation of innate immune response	"Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]	OMA
NV2t017834001.1	biological_process	GO:0002230	positive regulation of defense response to virus by host	"Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]	OMA
NV2t017834001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t017834001.1	biological_process	GO:0016239	positive regulation of macroautophagy	"Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]	OMA
NV2t017834001.1	biological_process	GO:0032092	positive regulation of protein binding	"Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t017834001.1	biological_process	GO:0032481	positive regulation of type I interferon production	"Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]	InterPro
NV2t017834001.1	biological_process	GO:0043330	response to exogenous dsRNA	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators]	OMA
NV2t017834001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t017834001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017834001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	OMA
NV2t017834001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t017834001.1	biological_process	GO:0051259	protein complex oligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929]	OMA
NV2t017834001.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t017834001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	PANTHER
NV2t017834001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t017834001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t017834001.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t017834001.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t017834001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t017834001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t017834001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t017834001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t017834001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017834001.1	cellular_component	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	OMA
NV2t017834001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t017834001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t017834001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t017834001.1	molecular_function	GO:0035438	cyclic-di-GMP binding	"Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate." [GOC:bf]	OMA
NV2t017834001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t017834001.1	molecular_function	GO:0061507	2',3'-cyclic GMP-AMP binding	"Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages." [GOC:dph, PMID:23258412, PMID:23910378]	OMA
NV2t017834001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t017835001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t017835001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t017835001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017835001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017835001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t017836001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017837001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t017837001.1	biological_process	GO:0006637	acyl-CoA metabolic process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]	OMA
NV2t017837001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t017837001.1	cellular_component	GO:0009361	succinate-CoA ligase complex (ADP-forming)	"A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [GOC:jl, PMID:9874242]	PANTHER
NV2t017837001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t017837001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t017837001.1	molecular_function	GO:0004774	succinate-CoA ligase activity	"Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [GOC:ai]	OMA
NV2t017842001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017842001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017844001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t017844001.1	biological_process	GO:0016578	obsolete histone deubiquitination	"OBSOLETE. The modification of histones by removal of ubiquitin groups." [GOC:ai]	OMA
NV2t017844001.1	biological_process	GO:0045739	positive regulation of DNA repair	"Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators]	OMA
NV2t017844001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	OMA
NV2t017844001.1	cellular_component	GO:0070531	BRCA1-A complex	"A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749]	InterPro
NV2t017844001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t017844001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t017844001.1	molecular_function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341]	OMA
NV2t017844002.1	cellular_component	GO:0070531	BRCA1-A complex	"A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749]	InterPro
NV2t017845001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t017845001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t017845001.1	biological_process	GO:0007041	lysosomal transport	"The directed movement of substances into, out of or within a lysosome." [GOC:ai]	OMA
NV2t017845001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t017845001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t017845001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t017845001.1	biological_process	GO:0048854	brain morphogenesis	"The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]	OMA
NV2t017845001.1	cellular_component	GO:0000938	GARP complex	"A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]	OMA
NV2t017845001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017845001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t017845001.1	cellular_component	GO:1990745	EARP complex	"A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]	PANTHER
NV2t017845001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017845002.1	cellular_component	GO:1990745	EARP complex	"A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]	PANTHER
NV2t017845003.1	cellular_component	GO:1990745	EARP complex	"A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061]	PANTHER
NV2t017846001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t017846002.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t017849001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t017849001.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	OMA
NV2t017849001.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	PANTHER
NV2t017850001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t017850001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017850001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017852001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017852001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t017852001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017852002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017852002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t017852002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017852003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017852003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t017852003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t017852003.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t017852004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017852004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t017853001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t017853001.1	molecular_function	GO:0005518	collagen binding	"Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732]	OMA
NV2t017853001.1	molecular_function	GO:0008201	heparin binding	"Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t017853001.1	molecular_function	GO:0016504	peptidase activator activity	"Binds to and increases the activity of a peptidase." [GOC:ai]	OMA
NV2t017854001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t017854001.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t017854001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t017854001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t017854001.1	biological_process	GO:1901658	glycosyl compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t017854001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t017854001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t017856001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t017856001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t017856001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t017856001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	InterPro
NV2t017856001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t017856001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017856001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t017856001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t017858001.1	biological_process	GO:0050708	regulation of protein secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	PANTHER
NV2t017859001.1	biological_process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]	OMA
NV2t017859001.1	biological_process	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	OMA
NV2t017859001.1	biological_process	GO:0061101	neuroendocrine cell differentiation	"The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph]	OMA
NV2t017859001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	OMA
NV2t017859001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t017859001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t017859001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t017859001.1	cellular_component	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	"Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc]	OMA
NV2t017859001.1	cellular_component	GO:0097431	mitotic spindle pole	"Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]	OMA
NV2t017859001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t017859001.1	molecular_function	GO:0019207	kinase regulator activity	"Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]	OMA
NV2t017863001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017863002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017864001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t017865001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017865002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017865003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017865004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017867001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t017867001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t017867001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t017867001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t017867002.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t017867003.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t017867004.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	PANTHER
NV2t017869001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017869001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t017869001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017869001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017872001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t017877001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t017877002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017878001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t017878001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t017878001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t017878001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t017879001.1	molecular_function	GO:0017171	serine hydrolase activity	"Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]	PANTHER
NV2t017881001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t017881001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t017881001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t017883001.1	biological_process	GO:0008154	actin polymerization or depolymerization	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t017883001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t017883001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017883001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t017883001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t017883001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t017884001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t017884001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017885001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t017885002.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t017885003.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t017886001.1	biological_process	GO:0006801	superoxide metabolic process	"The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl]	OMA
NV2t017886001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t017886001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t017886002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t017887001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017887001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017887001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t017888001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t017888001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017888002.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t017888002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017889001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017889001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t017889001.1	biological_process	GO:0007409	axonogenesis	"De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]	OMA
NV2t017889001.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t017889001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017889001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t017889001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t017889001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t017889001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017889001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017889002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017889002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t017889002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017890001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017890001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	PANTHER
NV2t017890001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017893001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017895001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017896001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t017896001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017896001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t017896001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t017896001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t017896001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t017898001.1	molecular_function	GO:0003796	lysozyme activity	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan." [EC:3.2.1.17, PMID:22748813]	InterPro
NV2t017898001.1	molecular_function	GO:0003796	lysozyme activity	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan." [EC:3.2.1.17, PMID:22748813]	OMA
NV2t017899001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017899001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017899002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017899002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017899003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017899003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017900001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t017900001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t017900001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t017900001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017901001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t017901002.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t017902001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t017904001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017904001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t017904001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017904001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017906001.1	biological_process	GO:1902412	regulation of mitotic cytokinesis	"Any process that modulates the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t017906001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017907001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	InterPro
NV2t017907001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t017907001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t017907001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t017908001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017908002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017910001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t017910001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t017910001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017910001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017911001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017911001.1	biological_process	GO:0006986	response to unfolded protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]	InterPro
NV2t017911001.1	biological_process	GO:0006986	response to unfolded protein	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]	OMA
NV2t017911001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017911001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t017911001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t017913001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t017916001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t017916001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t017916001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t017916001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t017916001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t017917001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017917001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017917001.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t017917001.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t017917002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t017917002.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t017917002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t017917002.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t017917002.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t017917002.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t017917002.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t017917002.1	molecular_function	GO:0033549	MAP kinase phosphatase activity	"Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316]	OMA
NV2t017920001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t017920001.1	cellular_component	GO:0005637	nuclear inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]	OMA
NV2t017920001.1	cellular_component	GO:0030659	cytoplasmic vesicle membrane	"The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]	OMA
NV2t017920001.1	cellular_component	GO:0031526	brush border membrane	"The portion of the plasma membrane surrounding the brush border." [GOC:mah]	OMA
NV2t017920001.1	cellular_component	GO:0031526	brush border membrane	"The portion of the plasma membrane surrounding the brush border." [GOC:mah]	PANTHER
NV2t017920001.1	molecular_function	GO:0008514	organic anion transmembrane transporter activity	"Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t017920001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t017921001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t017921001.1	biological_process	GO:0048016	obsolete inositol phosphate-mediated signaling	"OBSOLETE. A intracellular signal transduction in which the signal is transmitted within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6)." [GOC:bf, GOC:ceb, GOC:signaling, ISBN:0198506732, PMID:11331907]	PANTHER
NV2t017922001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017924001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017924001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t017924001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t017924001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017924001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017924001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t017925001.1	biological_process	GO:0018205	peptidyl-lysine modification	"The modification of peptidyl-lysine." [GOC:go_curators]	OMA
NV2t017925001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t017925001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t017925001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017925001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t017925001.1	molecular_function	GO:0017118	lipoyltransferase activity	"Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N6-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H+." [PMID:10103005, RHEA:20473]	PANTHER
NV2t017926001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017926001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017926001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017926001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017926002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t017926002.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t017926002.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t017926002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017926002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017926002.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t017926002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017926002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017926003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017926003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017926003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017926003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017926004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017926004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017926004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017926004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017926005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t017926005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t017926005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017926005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017928001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017928002.1	biological_process	GO:0001667	ameboidal-type cell migration	"Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]	OMA
NV2t017928002.1	biological_process	GO:0003008	system process	"A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]	OMA
NV2t017928002.1	biological_process	GO:0007369	gastrulation	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]	OMA
NV2t017928002.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t017928002.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t017928002.1	biological_process	GO:0022612	gland morphogenesis	"The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete]	OMA
NV2t017928002.1	biological_process	GO:0035107	appendage morphogenesis	"The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089]	OMA
NV2t017928002.1	biological_process	GO:0042632	cholesterol homeostasis	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]	OMA
NV2t017928002.1	biological_process	GO:0044238	primary metabolic process	"The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]	OMA
NV2t017928002.1	biological_process	GO:0044281	small molecule metabolic process	"The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t017928002.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t017928002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t017928002.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t017928002.1	biological_process	GO:0048534	hematopoietic or lymphoid organ development	"The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149]	OMA
NV2t017928002.1	biological_process	GO:0048592	eye morphogenesis	"The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu]	OMA
NV2t017928002.1	biological_process	GO:0048754	branching morphogenesis of an epithelial tube	"The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t017928002.1	biological_process	GO:0050796	regulation of insulin secretion	"Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai]	OMA
NV2t017928002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t017928002.1	biological_process	GO:0061448	connective tissue development	"The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF]	OMA
NV2t017928002.1	biological_process	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	OMA
NV2t017928002.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	OMA
NV2t017928002.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t017928002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017928002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t017928002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017928002.1	molecular_function	GO:0015026	coreceptor activity	"Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]	OMA
NV2t017928002.1	molecular_function	GO:0017147	Wnt-protein binding	"Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]	OMA
NV2t017928002.1	molecular_function	GO:0042813	Wnt receptor activity	"Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]	OMA
NV2t017928003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017929001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t017931001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	PANTHER
NV2t017935001.1	biological_process	GO:0034470	obsolete ncRNA processing	"OBSOLETE. Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah, PMID:27573892]	InterPro
NV2t017935001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t017935001.1	molecular_function	GO:1990883	rRNA cytidine N-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA." [PMID:25402480]	PANTHER
NV2t017936001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t017938001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t017938001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t017938002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t017938002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t017938003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t017938003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t017940001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t017940001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t017940001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017940002.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t017940002.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t017940002.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t017940002.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t017940002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t017940002.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017940002.1	molecular_function	GO:0019202	amino acid kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]	OMA
NV2t017940003.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t017940003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t017940003.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017940004.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	InterPro
NV2t017940004.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t017940004.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017941001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t017941001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017943001.1	molecular_function	GO:0099122	RNA polymerase II C-terminal domain binding	"Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function." [PMID:20889714]	OMA
NV2t017943001.1	molecular_function	GO:0099122	RNA polymerase II C-terminal domain binding	"Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function." [PMID:20889714]	PANTHER
NV2t017945001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t017945001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t017945001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t017945001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t017945001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t017945001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017945001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t017945001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t017945001.1	molecular_function	GO:0046332	SMAD binding	"Binding to a SMAD signaling protein." [GOC:ai]	OMA
NV2t017945002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t017945002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t017945003.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t017945003.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t017945003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t017945004.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t017945004.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t017945004.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t017947001.1	biological_process	GO:0032483	regulation of Rab protein signal transduction	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]	OMA
NV2t017947001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t017947001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t017947001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017947001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t017947002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t017949001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017949001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t017949001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017949002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t017949002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	PANTHER
NV2t017949002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017950001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t017950001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t017950001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t017950001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t017950001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t017951001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	PANTHER
NV2t017951001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t017951001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t017953001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t017953001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t017953001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t017953001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t017953001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017954001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017954002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017954003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017955001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t017955001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t017955001.1	cellular_component	GO:0036128	CatSper complex	"A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039]	InterPro
NV2t017959001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017961001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017961001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t017961001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017964001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017964001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	InterPro
NV2t017964001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	OMA
NV2t017965001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t017965001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t017965001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	OMA
NV2t017965001.1	cellular_component	GO:0000176	nuclear exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t017965001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t017965001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017965001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017965001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t017965001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017967001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t017968001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t017968001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t017968002.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t017968002.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t017970001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t017970001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	PANTHER
NV2t017971001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t017971001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t017971001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t017971001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t017972002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t017972002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t017972003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t017972003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t017972004.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t017972004.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t017973001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t017973001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t017973001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017973001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t017973001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017974001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017974002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t017974002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017974002.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t017974002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017974002.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t017975001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t017975001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t017975001.1	biological_process	GO:0051231	spindle elongation	"The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai]	OMA
NV2t017975001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	OMA
NV2t017975001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	PANTHER
NV2t017975001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017975001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t017975001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t017975001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017975001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t017975001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t017975001.1	molecular_function	GO:0008574	plus-end-directed microtubule motor activity	"A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis." [GOC:vw, PMID:32842864]	OMA
NV2t017976001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t017976001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t017976001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t017976001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t017976001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t017976001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t017976001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t017976001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t017976001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t017976001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t017977001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t017978001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	InterPro
NV2t017978001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017979001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017981001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	PANTHER
NV2t017983001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t017983001.1	molecular_function	GO:0071207	histone pre-mRNA stem-loop binding	"Binding to a conserved stem-loop structure found in histone pre-mRNAs." [PMID:19470752]	PANTHER
NV2t017986001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017986001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t017987001.1	biological_process	GO:0031848	protection from non-homologous end joining at telomere	"A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah]	OMA
NV2t017987001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t017987001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t017987001.1	molecular_function	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	InterPro
NV2t017987001.1	molecular_function	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	OMA
NV2t017987002.1	molecular_function	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	InterPro
NV2t017987003.1	molecular_function	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	InterPro
NV2t017988001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t017988001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017988001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	InterPro
NV2t017988001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	OMA
NV2t017988001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t017988001.1	cellular_component	GO:0030122	AP-2 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426]	OMA
NV2t017988001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t017988001.1	molecular_function	GO:0035615	clathrin adaptor activity	"Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]	OMA
NV2t017988001.1	molecular_function	GO:0140312	cargo adaptor activity	"Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]	PANTHER
NV2t017988002.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t017988002.1	molecular_function	GO:0140312	cargo adaptor activity	"Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]	PANTHER
NV2t017988003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t017988003.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t017988003.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t017988003.1	molecular_function	GO:0140312	cargo adaptor activity	"Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254]	PANTHER
NV2t017989001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t017989001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t017989001.1	biological_process	GO:2001222	regulation of neuron migration	"Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol]	OMA
NV2t017989001.1	biological_process	GO:2001224	positive regulation of neuron migration	"Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol]	PANTHER
NV2t017989001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017989001.1	cellular_component	GO:0031252	cell leading edge	"The area of a motile cell closest to the direction of movement." [GOC:pg]	OMA
NV2t017989001.1	cellular_component	GO:0044295	axonal growth cone	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]	OMA
NV2t017991001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t017991001.1	biological_process	GO:0048477	oogenesis	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]	OMA
NV2t017991001.1	biological_process	GO:0048477	oogenesis	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]	PANTHER
NV2t017991001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t017991001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t017991001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017992001.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	InterPro
NV2t017992001.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	OMA
NV2t017992001.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t017992001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t017992001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t017992001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t017992001.1	molecular_function	GO:0004661	protein geranylgeranyltransferase activity	"Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375]	OMA
NV2t017992001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t017993001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t017993001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t017993001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t017993001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t017993001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t017993001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t017993001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t017996001.1	biological_process	GO:0006221	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t017996001.1	biological_process	GO:0006231	dTMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732]	InterPro
NV2t017996001.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t017996001.1	biological_process	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t017996001.1	biological_process	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t017996001.1	biological_process	GO:0009219	pyrimidine deoxyribonucleotide metabolic process	"The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t017996001.1	biological_process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]	OMA
NV2t017996001.1	biological_process	GO:0046653	tetrahydrofolate metabolic process	"The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	OMA
NV2t017996001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t017996001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t017996001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t017996001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t017996001.1	molecular_function	GO:0000900	mRNA regulatory element binding translation repressor activity	"Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370]	OMA
NV2t017996001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t017996001.1	molecular_function	GO:0016741	transferase activity, transferring one-carbon groups	"Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t017996001.1	molecular_function	GO:1990825	sequence-specific mRNA binding	"Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]	OMA
NV2t017998001.1	biological_process	GO:0022904	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	InterPro
NV2t017998001.1	biological_process	GO:0022904	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	OMA
NV2t017998001.1	biological_process	GO:0022904	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	PANTHER
NV2t017998001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t017999001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017999001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t017999002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t017999002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018002001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t018003001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t018003001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t018003001.1	molecular_function	GO:0004602	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]	OMA
NV2t018006001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018007001.1	biological_process	GO:0006144	purine nucleobase metabolic process	"The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]	OMA
NV2t018007001.1	biological_process	GO:0006145	purine nucleobase catabolic process	"The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]	PANTHER
NV2t018007001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t018007001.1	biological_process	GO:0072523	purine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t018007001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018007001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018007001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t018007001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t018007001.1	molecular_function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	InterPro
NV2t018007001.1	molecular_function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	OMA
NV2t018007001.1	molecular_function	GO:0050897	cobalt ion binding	"Binding to a cobalt ion (Co2+)." [GOC:ai]	InterPro
NV2t018007002.1	biological_process	GO:0006145	purine nucleobase catabolic process	"The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]	PANTHER
NV2t018007002.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t018010001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t018010001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	InterPro
NV2t018010001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t018010001.1	biological_process	GO:0071480	cellular response to gamma radiation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]	OMA
NV2t018010001.1	biological_process	GO:0071481	cellular response to X-ray	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah]	OMA
NV2t018010001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t018010001.1	cellular_component	GO:0043564	Ku70:Ku80 complex	"Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]	InterPro
NV2t018010001.1	cellular_component	GO:0043564	Ku70:Ku80 complex	"Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]	OMA
NV2t018010001.1	cellular_component	GO:0043564	Ku70:Ku80 complex	"Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]	PANTHER
NV2t018010001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t018010001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t018010001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t018010001.1	molecular_function	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	OMA
NV2t018010002.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	InterPro
NV2t018010002.1	cellular_component	GO:0043564	Ku70:Ku80 complex	"Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]	InterPro
NV2t018010002.1	cellular_component	GO:0043564	Ku70:Ku80 complex	"Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]	PANTHER
NV2t018011001.1	biological_process	GO:0010922	positive regulation of phosphatase activity	"Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t018011001.1	biological_process	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	OMA
NV2t018011001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t018011001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t018011001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	OMA
NV2t018011001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t018011001.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t018011001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t018012001.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t018012002.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t018012003.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t018013001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t018013001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t018013001.1	molecular_function	GO:0016878	acid-thiol ligase activity	"Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1.-, GOC:mah]	OMA
NV2t018013001.1	molecular_function	GO:0050218	propionate-CoA ligase activity	"Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN]	PANTHER
NV2t018015001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t018015001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t018015001.1	biological_process	GO:0045004	DNA replication proofreading	"Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai]	OMA
NV2t018015001.1	biological_process	GO:0045004	DNA replication proofreading	"Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai]	PANTHER
NV2t018015001.1	cellular_component	GO:0043625	delta DNA polymerase complex	"A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]	OMA
NV2t018015001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t018015001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018015001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018015001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018015001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	InterPro
NV2t018015001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t018015001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018015001.1	molecular_function	GO:0008296	3'-5'-DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]	OMA
NV2t018019001.1	cellular_component	GO:0090537	CERF complex	"An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters." [GOC:krc]	InterPro
NV2t018019001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018020001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018021001.1	biological_process	GO:0048066	developmental pigmentation	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]	PANTHER
NV2t018021001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018021002.1	biological_process	GO:0048066	developmental pigmentation	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]	PANTHER
NV2t018021002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018021003.1	biological_process	GO:0048066	developmental pigmentation	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]	PANTHER
NV2t018021003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018022001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018022001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t018022001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t018022001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t018023001.1	biological_process	GO:0006812	monoatomic cation transport	"The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t018023001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t018023001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018023001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t018023001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t018024001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t018024001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018024001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018024001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018024001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018026001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t018026001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018026001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018026001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018026001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018027001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018027001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018027001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018028001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	InterPro
NV2t018028001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	OMA
NV2t018028001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t018031001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t018031001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t018032001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t018032001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t018032001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t018032001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018032001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018033001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018033001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018038001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018038001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t018038001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018039001.1	biological_process	GO:0006828	manganese ion transport	"The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t018039001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t018039001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018039001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t018039001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018039001.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t018039001.1	molecular_function	GO:0015279	store-operated calcium channel activity	"A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]	OMA
NV2t018039001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t018039001.1	molecular_function	GO:0043178	alcohol binding	"Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]	OMA
NV2t018039001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t018041001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t018041001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t018042001.1	biological_process	GO:0048250	iron import into the mitochondrion	"The process in which iron is transported from the cytosol into the mitochondrial matrix." [GOC:jid, PMID:12006577]	OMA
NV2t018042001.1	biological_process	GO:0048250	iron import into the mitochondrion	"The process in which iron is transported from the cytosol into the mitochondrial matrix." [GOC:jid, PMID:12006577]	PANTHER
NV2t018042001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t018042001.1	molecular_function	GO:0005381	iron ion transmembrane transporter activity	"Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t018043001.1	biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]	PANTHER
NV2t018043001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018046001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t018046001.1	biological_process	GO:0012501	programmed cell death	"A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis]	OMA
NV2t018046001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t018046001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t018046001.1	biological_process	GO:0070372	regulation of ERK1 and ERK2 cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]	OMA
NV2t018046001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018046001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018046001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t018046001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t018046001.1	molecular_function	GO:0046570	methylthioribulose 1-phosphate dehydratase activity	"Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O." [EC:4.2.1.109, RHEA:15549]	PANTHER
NV2t018046001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018054001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t018054001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018056001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t018057001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t018057001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t018057001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018057001.1	molecular_function	GO:0016842	amidine-lyase activity	"Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]	OMA
NV2t018057001.1	molecular_function	GO:0061928	glutathione specific gamma-glutamylcyclotransferase activity	"Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine." [PMID:23070364, PMID:27913623]	InterPro
NV2t018058001.1	biological_process	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	InterPro
NV2t018058001.1	biological_process	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]	OMA
NV2t018058001.1	biological_process	GO:0006221	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t018058001.1	biological_process	GO:0006222	UMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732]	OMA
NV2t018058001.1	biological_process	GO:0019856	pyrimidine nucleobase biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]	PANTHER
NV2t018058001.1	biological_process	GO:0044205	'de novo' UMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen." [GOC:ecd, GOC:jl]	InterPro
NV2t018058001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018058001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018058001.1	molecular_function	GO:0004588	orotate phosphoribosyltransferase activity	"Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10]	InterPro
NV2t018058001.1	molecular_function	GO:0004588	orotate phosphoribosyltransferase activity	"Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10]	OMA
NV2t018058001.1	molecular_function	GO:0004590	orotidine-5'-phosphate decarboxylase activity	"Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP." [EC:4.1.1.23, RHEA:11596]	OMA
NV2t018059001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	InterPro
NV2t018059001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t018060001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018064001.1	molecular_function	GO:0050308	sugar-phosphatase activity	"Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN]	PANTHER
NV2t018066001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018067001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	InterPro
NV2t018069001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018070001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t018070001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018072001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t018072002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t018072003.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t018072004.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t018073001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t018073001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018077001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018077001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t018077001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018077001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t018077001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t018077001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018077001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018077001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018079001.1	molecular_function	GO:0048018	receptor ligand activity	"The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]	PANTHER
NV2t018081001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t018083001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018084001.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t018084001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018085001.1	biological_process	GO:0006264	mitochondrial DNA replication	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]	OMA
NV2t018085001.1	biological_process	GO:0009411	response to UV	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]	OMA
NV2t018085001.1	biological_process	GO:0019985	translesion synthesis	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]	OMA
NV2t018085001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t018085001.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	InterPro
NV2t018085001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018085001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t018085001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t018085001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t018085001.1	molecular_function	GO:0003896	DNA primase activity	"Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer." [GOC:mah, GOC:mcc, PMID:11395402, PMID:26184436, PMID:38203225, PMID:38492718]	OMA
NV2t018086001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018086001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t018086001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018086002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018086002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t018086002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018089001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018089001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018089001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t018089001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018089002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018089002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018089002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t018089002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018089003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018089003.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t018089003.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t018089003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018089003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018089003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t018089003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t018089003.1	molecular_function	GO:0005007	fibroblast growth factor receptor activity	"Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]	OMA
NV2t018089003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018089003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018089003.1	molecular_function	GO:0019838	growth factor binding	"Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators]	OMA
NV2t018091001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t018091001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	PANTHER
NV2t018091001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018091001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018092001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	PANTHER
NV2t018092001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t018093001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t018097001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t018099001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	PANTHER
NV2t018099001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018101001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t018101001.1	molecular_function	GO:0003968	RNA-dependent RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]	InterPro
NV2t018101002.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t018101002.1	molecular_function	GO:0003968	RNA-dependent RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]	InterPro
NV2t018103001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t018103002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018103002.1	molecular_function	GO:0005007	fibroblast growth factor receptor activity	"Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]	OMA
NV2t018103002.1	molecular_function	GO:0019838	growth factor binding	"Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators]	OMA
NV2t018104001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018104001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t018104001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018104001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018106001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t018106001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018106001.1	biological_process	GO:0097681	double-strand break repair via alternative nonhomologous end joining	"An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining]	PANTHER
NV2t018106001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018107001.1	biological_process	GO:0009631	cold acclimation	"Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]	OMA
NV2t018107001.1	biological_process	GO:0045724	positive regulation of cilium assembly	"Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]	OMA
NV2t018107001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t018107001.1	biological_process	GO:0070417	cellular response to cold	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp]	OMA
NV2t018107001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t018107001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t018107001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t018107001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t018107001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t018107001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t018107001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t018107001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t018107002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t018107002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t018108001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018108001.1	molecular_function	GO:0070063	RNA polymerase binding	"Binding to an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH]	InterPro
NV2t018110001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t018110001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018111001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t018111001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	OMA
NV2t018111001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	PANTHER
NV2t018111001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018111001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018111001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018111001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t018111001.1	molecular_function	GO:0030695	GTPase regulator activity	"Binds to and modulates the activity of a GTPase." [GOC:mah]	InterPro
NV2t018112001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	PANTHER
NV2t018112001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018114001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t018115001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018116001.1	biological_process	GO:0006805	xenobiotic metabolic process	"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc]	OMA
NV2t018116001.1	biological_process	GO:0009404	toxin metabolic process	"The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2]	OMA
NV2t018116001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t018116001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018116001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t018116001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t018116002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t018117001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t018117001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t018117001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018119001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t018119001.1	biological_process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210]	OMA
NV2t018119001.1	biological_process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]	OMA
NV2t018119001.1	biological_process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]	PANTHER
NV2t018119001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t018119001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018119001.1	molecular_function	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]	OMA
NV2t018120001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018120001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018120001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t018120002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018121001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t018121001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t018121001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t018121001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t018121001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t018121001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018121001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018121001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018122001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t018122002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t018122003.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t018122004.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t018123001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t018123001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	PANTHER
NV2t018123001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018123001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t018123001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018123001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018123001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018125001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018125001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018125002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018125002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018125003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018125003.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018125004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018125004.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018127001.1	biological_process	GO:0003008	system process	"A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]	OMA
NV2t018127001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t018127001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018127001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018127001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t018127001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t018127001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t018127001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018131001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t018133001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t018133001.1	biological_process	GO:0017157	regulation of exocytosis	"Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]	PANTHER
NV2t018133001.1	cellular_component	GO:0035253	ciliary rootlet	"A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]	OMA
NV2t018133001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t018133001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018133001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018133001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018134001.1	biological_process	GO:0010605	negative regulation of macromolecule metabolic process	"Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t018134001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t018134001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t018134001.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	PANTHER
NV2t018134001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018134001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	OMA
NV2t018135001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t018135002.1	biological_process	GO:0000055	ribosomal large subunit export from nucleus	"The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t018135002.1	biological_process	GO:0000056	ribosomal small subunit export from nucleus	"The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t018135002.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t018135002.1	biological_process	GO:0006405	RNA export from nucleus	"The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t018135002.1	biological_process	GO:0010824	regulation of centrosome duplication	"Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]	OMA
NV2t018135002.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t018135002.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t018135002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018135002.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t018135002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t018135002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018135002.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t018135002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t018135002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018135002.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t018135002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018135002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t018135002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t018135003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018135003.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t018135004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018135004.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t018135005.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t018137001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t018137001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t018137001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t018137001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t018137001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018137001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018137001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t018137001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t018137001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t018137002.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t018137002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t018140001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t018140001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018141001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018141001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t018146001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018146001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018146001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018147001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t018151001.1	cellular_component	GO:0048476	Holliday junction resolvase complex	"An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated." [PMID:11207366, PMID:12374758]	PANTHER
NV2t018151001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t018152001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018152001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018152001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t018153001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018153001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t018153001.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	PANTHER
NV2t018153001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t018153002.1	biological_process	GO:0001678	intracellular glucose homeostasis	"A homeostatic process involved in the maintenance of a steady state level of glucose within a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t018153002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018153002.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t018153002.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	OMA
NV2t018153002.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t018153002.1	biological_process	GO:0032024	positive regulation of insulin secretion	"Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah]	OMA
NV2t018153002.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	OMA
NV2t018153002.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	PANTHER
NV2t018153002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t018153002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018153002.1	molecular_function	GO:0004396	hexokinase activity	"Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1]	OMA
NV2t018153002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018153002.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t018153002.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t018153003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018153003.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t018153003.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	PANTHER
NV2t018153003.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t018153004.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018153004.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t018153004.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	PANTHER
NV2t018153004.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t018153005.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018153005.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t018153005.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	PANTHER
NV2t018153005.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t018153006.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018153006.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t018153006.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	PANTHER
NV2t018153006.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t018154001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t018154001.1	cellular_component	GO:0016591	RNA polymerase II, holoenzyme	"A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii]	OMA
NV2t018154001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t018154001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018154001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	PANTHER
NV2t018155001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t018156001.1	biological_process	GO:0070935	3'-UTR-mediated mRNA stabilization	"An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303]	PANTHER
NV2t018156001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018156001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018157001.1	biological_process	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]	InterPro
NV2t018157001.1	biological_process	GO:0016320	endoplasmic reticulum membrane fusion	"The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid]	OMA
NV2t018157001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t018157001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t018157001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t018157001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t018157001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t018158001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018158001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t018158002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018158002.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t018160001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018160001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	PANTHER
NV2t018160001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018160001.1	molecular_function	GO:0015075	monoatomic ion transmembrane transporter activity	"Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018163001.1	biological_process	GO:0007288	sperm axoneme assembly	"The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t018163001.1	biological_process	GO:1901317	regulation of flagellated sperm motility	"Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie]	OMA
NV2t018163001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t018163001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t018163001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t018163001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t018163001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t018163001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	PANTHER
NV2t018163002.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	PANTHER
NV2t018164001.1	biological_process	GO:0045724	positive regulation of cilium assembly	"Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]	PANTHER
NV2t018164002.1	biological_process	GO:0045724	positive regulation of cilium assembly	"Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]	PANTHER
NV2t018166001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t018166001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018166001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018167001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t018167001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t018167001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t018167001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018167001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018167001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018167001.1	molecular_function	GO:0017069	snRNA binding	"Binding to a small nuclear RNA (snRNA)." [GOC:mah]	OMA
NV2t018167001.1	molecular_function	GO:0097157	pre-mRNA intronic binding	"Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624]	OMA
NV2t018167001.1	molecular_function	GO:0097157	pre-mRNA intronic binding	"Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624]	PANTHER
NV2t018168001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018168003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168008.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168009.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168010.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168011.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168012.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168013.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018168015.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018170001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t018170001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	PANTHER
NV2t018170001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t018170001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t018172001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018172001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018172002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018173001.1	biological_process	GO:0032095	regulation of response to food	"Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add]	OMA
NV2t018173001.1	biological_process	GO:0032098	regulation of appetite	"Any process which modulates appetite, the desire or physical craving for food." [GOC:add]	OMA
NV2t018173001.1	biological_process	GO:0032102	negative regulation of response to external stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t018173001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t018173001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	PANTHER
NV2t018173001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018173001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t018174001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t018180001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t018180001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t018180001.1	biological_process	GO:0038060	nitric oxide-cGMP-mediated signaling	"An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632]	OMA
NV2t018180001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	OMA
NV2t018180001.1	biological_process	GO:0070482	response to oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]	PANTHER
NV2t018180001.1	cellular_component	GO:0008074	guanylate cyclase complex, soluble	"Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]	OMA
NV2t018180001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t018180001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t018180001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t018180002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018182001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018182001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018182001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018182002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018182002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018182002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018182003.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018182003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018182003.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018183001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018183001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018183001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018183002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018183002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018183002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018183003.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018183003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018183003.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018183004.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018183004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018183004.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018183005.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018183005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018183005.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018184001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018184001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018184001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018185001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018185001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018185001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018186001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018186001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018186001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018186002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018186002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018186002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018188001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	PANTHER
NV2t018190001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t018190001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018192001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t018192001.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t018192001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018192002.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t018192002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018192003.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t018192003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018194001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t018194001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018195001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018195001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018195001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018198001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t018199001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t018199001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t018199001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	OMA
NV2t018199001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	PANTHER
NV2t018200001.1	cellular_component	GO:0030686	90S preribosome	"A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]	PANTHER
NV2t018201001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018201001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t018201001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t018205001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	InterPro
NV2t018205001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t018205001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t018205002.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	InterPro
NV2t018205002.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t018207001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018207001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018207001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t018207001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018207001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018209001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t018213001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t018217001.1	biological_process	GO:0006274	DNA replication termination	"The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298]	OMA
NV2t018217001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t018217001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t018217001.1	biological_process	GO:0071241	cellular response to inorganic substance	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah]	OMA
NV2t018217001.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t018217001.1	biological_process	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	OMA
NV2t018217001.1	biological_process	GO:1902979	mitotic DNA replication termination	"Any DNA replication termination involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]	InterPro
NV2t018217001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018217001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t018217001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018218001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t018218001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t018218001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t018218001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018218001.1	cellular_component	GO:0034657	GID complex	"A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species." [PMID:12686616, PMID:18508925, PMID:35682545]	OMA
NV2t018218001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018218001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t018218001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t018220001.1	biological_process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	"Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation." [GOC:BHF]	PANTHER
NV2t018220001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018221001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018221001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018228001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t018228001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018228001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t018228001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t018231001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t018231001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018231001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t018234001.1	cellular_component	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	PANTHER
NV2t018234002.1	cellular_component	GO:0099503	secretory vesicle	"A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos]	PANTHER
NV2t018235001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	PANTHER
NV2t018240002.1	molecular_function	GO:0009019	obsolete tRNA (guanine-N1-)-methyltransferase activity	"OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [GOC:curators, PMID:782564]	PANTHER
NV2t018241001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t018241001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t018241001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018241001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t018242001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t018245001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	PANTHER
NV2t018245002.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	PANTHER
NV2t018246001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t018246001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018246001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018246002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t018246002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018246002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018246003.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t018246003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018246003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018246004.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t018246004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018246004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018246005.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t018246005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018246005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018247001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	InterPro
NV2t018247001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t018247001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018249001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	PANTHER
NV2t018250001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t018250001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t018250001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t018250001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t018250001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t018250001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t018253001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018254001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t018254001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018254001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018254001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t018255001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t018255001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018268001.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	InterPro
NV2t018268001.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	OMA
NV2t018268001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018268001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018268001.1	molecular_function	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+." [RHEA:11020]	OMA
NV2t018268001.1	molecular_function	GO:0051765	inositol tetrakisphosphate kinase activity	"Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai]	OMA
NV2t018268001.1	molecular_function	GO:0051765	inositol tetrakisphosphate kinase activity	"Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai]	PANTHER
NV2t018269001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t018270001.1	biological_process	GO:0006898	receptor-mediated endocytosis	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]	OMA
NV2t018270001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t018270001.1	biological_process	GO:0007416	synapse assembly	"The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah]	OMA
NV2t018270001.1	biological_process	GO:0010976	positive regulation of neuron projection development	"Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t018270001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018270001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t018270001.1	biological_process	GO:0045773	positive regulation of axon extension	"Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators]	OMA
NV2t018270001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t018270001.1	biological_process	GO:0050775	positive regulation of dendrite morphogenesis	"Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]	OMA
NV2t018270001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t018270001.1	biological_process	GO:0098974	postsynaptic actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos]	PANTHER
NV2t018270001.1	biological_process	GO:0099175	regulation of postsynapse organization	"Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t018270001.1	biological_process	GO:0099188	postsynaptic cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos]	OMA
NV2t018270001.1	biological_process	GO:0120031	plasma membrane bounded cell projection assembly	"Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t018270001.1	biological_process	GO:0140694	non-membrane-bounded organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081]	OMA
NV2t018270001.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t018270001.1	cellular_component	GO:0002102	podosome	"An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]	OMA
NV2t018270001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t018270001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t018270001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t018270001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t018270001.1	cellular_component	GO:0030427	site of polarized growth	"Any part of a cell where non-isotropic growth takes place." [GOC:mah]	OMA
NV2t018270001.1	cellular_component	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	OMA
NV2t018270001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t018270001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t018270001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018270001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t018273001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t018273001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018273001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018273001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018274001.1	biological_process	GO:0019835	cytolysis	"The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204]	OMA
NV2t018274001.1	biological_process	GO:0050829	defense response to Gram-negative bacterium	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]	OMA
NV2t018274001.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t018274001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018274001.1	molecular_function	GO:0140911	pore-forming activity	"An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death." [PMID:1406491, PMID:25157079, PMID:34387717]	InterPro
NV2t018275001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	PANTHER
NV2t018275003.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	PANTHER
NV2t018276001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	InterPro
NV2t018276001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	PANTHER
NV2t018277001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t018277001.1	molecular_function	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3.-, GOC:mah]	OMA
NV2t018277001.1	molecular_function	GO:0047750	cholestenol delta-isomerase activity	"Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [RHEA:15281]	InterPro
NV2t018278001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018278001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018278001.1	molecular_function	GO:0051184	obsolete cofactor transmembrane transporter activity	"OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]	PANTHER
NV2t018279001.1	biological_process	GO:0110104	mRNA alternative polyadenylation	"The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals)." [GOC:ans, PMID:28453393, PMID:29276085]	PANTHER
NV2t018279001.1	cellular_component	GO:0005849	mRNA cleavage factor complex	"Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856]	OMA
NV2t018279001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018279001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018279001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018279002.1	biological_process	GO:0110104	mRNA alternative polyadenylation	"The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals)." [GOC:ans, PMID:28453393, PMID:29276085]	PANTHER
NV2t018279002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018279003.1	biological_process	GO:0110104	mRNA alternative polyadenylation	"The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals)." [GOC:ans, PMID:28453393, PMID:29276085]	PANTHER
NV2t018279003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018279003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018279004.1	biological_process	GO:0110104	mRNA alternative polyadenylation	"The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals)." [GOC:ans, PMID:28453393, PMID:29276085]	PANTHER
NV2t018279004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018279004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018281001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018281001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t018281001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t018281001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t018281001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018281001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018281001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018281001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018282001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t018282001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018282001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018282002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t018282002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018283001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t018283001.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t018283001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t018283001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t018283001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t018283001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018283001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018283001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t018283001.1	molecular_function	GO:0030619	U1 snRNA binding	"Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah]	InterPro
NV2t018283001.1	molecular_function	GO:0030619	U1 snRNA binding	"Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah]	OMA
NV2t018283002.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t018283002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018283002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018284001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t018284001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t018284001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018284001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t018284001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t018284001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t018284001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t018284001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018284002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t018284002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018284002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t018284002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t018284002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018286001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t018286001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018286001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	PANTHER
NV2t018286001.1	cellular_component	GO:0044233	mitochondria-associated endoplasmic reticulum membrane contact site	"A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109]	OMA
NV2t018286001.1	molecular_function	GO:0017128	phospholipid scramblase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]	OMA
NV2t018288001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t018288001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t018288001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t018288001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	OMA
NV2t018288001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t018288001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t018288001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t018290001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t018290001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018292001.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t018292001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018292002.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t018292002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018292003.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	PANTHER
NV2t018292003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018293001.1	biological_process	GO:0045040	protein insertion into mitochondrial outer membrane	"The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes." [GOC:mcc, GOC:vw, PMID:18672008]	PANTHER
NV2t018293001.1	cellular_component	GO:0019867	outer membrane	"The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]	InterPro
NV2t018293002.1	biological_process	GO:0045040	protein insertion into mitochondrial outer membrane	"The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes." [GOC:mcc, GOC:vw, PMID:18672008]	PANTHER
NV2t018293002.1	cellular_component	GO:0019867	outer membrane	"The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]	InterPro
NV2t018294001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t018294001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t018294001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t018294001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018294001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t018294001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t018294001.1	molecular_function	GO:0060590	ATPase regulator activity	"Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]	OMA
NV2t018295001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	PANTHER
NV2t018297001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t018297002.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t018297003.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t018297003.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t018297003.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	OMA
NV2t018298001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t018298001.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	OMA
NV2t018298001.1	biological_process	GO:0035695	mitophagy by internal vacuole formation	"The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes." [GOC:autophagy, GOC:bf, GOC:sp, PMID:21264228]	PANTHER
NV2t018298001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t018302001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t018302001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t018302001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t018302001.1	biological_process	GO:0034446	substrate adhesion-dependent cell spreading	"The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732]	OMA
NV2t018302001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t018302001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t018302001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018304001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t018304001.1	molecular_function	GO:0032549	ribonucleoside binding	"Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]	InterPro
NV2t018306001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018306001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t018306001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018306001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018306002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018306002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t018306002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018306002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018310001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018310001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t018310001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018310001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018313001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018313001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t018313001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t018313001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018313001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018315001.1	cellular_component	GO:0031941	filamentous actin	"A two-stranded helical polymer of the protein actin." [GOC:mah]	PANTHER
NV2t018315001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018315002.1	cellular_component	GO:0031941	filamentous actin	"A two-stranded helical polymer of the protein actin." [GOC:mah]	PANTHER
NV2t018315002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018315003.1	cellular_component	GO:0031941	filamentous actin	"A two-stranded helical polymer of the protein actin." [GOC:mah]	PANTHER
NV2t018315003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018316001.1	cellular_component	GO:0031941	filamentous actin	"A two-stranded helical polymer of the protein actin." [GOC:mah]	PANTHER
NV2t018316001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018316002.1	cellular_component	GO:0031941	filamentous actin	"A two-stranded helical polymer of the protein actin." [GOC:mah]	PANTHER
NV2t018316002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018316003.1	cellular_component	GO:0031941	filamentous actin	"A two-stranded helical polymer of the protein actin." [GOC:mah]	PANTHER
NV2t018316003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018317001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t018317001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t018317001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018317001.1	molecular_function	GO:0004000	adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]	OMA
NV2t018317001.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t018317002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t018317002.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t018317003.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t018317003.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t018317004.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t018317004.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t018317005.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t018317005.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t018317006.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t018317006.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	PANTHER
NV2t018318001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t018318001.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t018318001.1	biological_process	GO:0038179	neurotrophin signaling pathway	"The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, Wikipedia:Neurotrophin]	OMA
NV2t018318001.1	biological_process	GO:0048011	neurotrophin TRK receptor signaling pathway	"The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor]	InterPro
NV2t018319001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018319001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t018319001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018319001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018319001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018321001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018321001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018321001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018324001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t018324002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t018329001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018329001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t018331001.1	biological_process	GO:0051983	regulation of chromosome segregation	"Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]	PANTHER
NV2t018331001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t018331001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018333001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t018333001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t018333001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018333001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t018333001.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	InterPro
NV2t018333001.1	molecular_function	GO:0043024	ribosomal small subunit binding	"Binding to a small ribosomal subunit." [GOC:go_curators]	OMA
NV2t018334001.1	biological_process	GO:0051262	protein tetramerization	"The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]	OMA
NV2t018334001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018334001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018334001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t018334001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	PANTHER
NV2t018334002.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	PANTHER
NV2t018340001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t018340001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	PANTHER
NV2t018341001.1	biological_process	GO:0048489	synaptic vesicle transport	"The directed movement of synaptic vesicles." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr]	OMA
NV2t018341001.1	cellular_component	GO:0008021	synaptic vesicle	"A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290]	OMA
NV2t018341001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t018344001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t018344001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018346002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346002.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018346003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346003.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018346004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346004.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018346005.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346005.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018346006.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346006.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018346007.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346007.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018346008.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t018346008.1	biological_process	GO:0050829	defense response to Gram-negative bacterium	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]	OMA
NV2t018346008.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t018346008.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018346008.1	molecular_function	GO:0001530	lipopolysaccharide binding	"Binding to a lipopolysaccharide." [PMID:11079463]	OMA
NV2t018346008.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018347001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t018347001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t018347001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t018348001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018348001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t018349001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t018349002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t018349002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018349002.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t018349002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t018349002.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t018349003.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t018350001.1	biological_process	GO:0038203	TORC2 signaling	"A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]	OMA
NV2t018350001.1	biological_process	GO:0038203	TORC2 signaling	"A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]	PANTHER
NV2t018350001.1	cellular_component	GO:0031932	TORC2 complex	"A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787]	OMA
NV2t018353001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t018354001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t018354001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t018354002.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t018354002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t018356001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t018358001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t018358001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018362001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018362001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018362001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018364001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t018364001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t018364002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t018364002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t018364002.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t018364002.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t018364002.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t018367001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t018367001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t018367001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018367001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t018369001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t018369001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t018369001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018369001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t018370001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t018370001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t018370001.1	biological_process	GO:0048753	pigment granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]	OMA
NV2t018370001.1	biological_process	GO:0070925	organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t018370001.1	cellular_component	GO:0031085	BLOC-3 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248]	OMA
NV2t018370001.1	cellular_component	GO:0031085	BLOC-3 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248]	PANTHER
NV2t018370001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t018371001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018371001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t018371001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018373001.1	biological_process	GO:0036353	obsolete histone H2A-K119 monoubiquitination	"OBSOLETE. The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022]	PANTHER
NV2t018373001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018374001.1	biological_process	GO:0036353	obsolete histone H2A-K119 monoubiquitination	"OBSOLETE. The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022]	PANTHER
NV2t018374001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018374001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t018376001.1	biological_process	GO:0006349	obsolete regulation of gene expression by genomic imprinting	"OBSOLETE. An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles." [PMID:11498578, PMID:31896690, PMID:7502071]	OMA
NV2t018376001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018376001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t018376001.1	biological_process	GO:0007549	sex-chromosome dosage compensation	"Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes." [GOC:ems, PMID:11498577, PMID:30049999, PMID:35306885]	OMA
NV2t018376001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t018376001.1	biological_process	GO:0036353	obsolete histone H2A-K119 monoubiquitination	"OBSOLETE. The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022]	PANTHER
NV2t018376001.1	cellular_component	GO:0000805	X chromosome	"The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system]	OMA
NV2t018376001.1	cellular_component	GO:0035102	PRC1 complex	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]	OMA
NV2t018376001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t018377001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t018377002.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	PANTHER
NV2t018378001.1	biological_process	GO:0001933	negative regulation of protein phosphorylation	"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t018378001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018378001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t018378001.1	biological_process	GO:0007029	endoplasmic reticulum organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0007254	JNK cascade	"A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation." [PMID:11790549, PMID:20811974, PMID:23125017]	OMA
NV2t018378001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t018378001.1	biological_process	GO:0007528	neuromuscular junction development	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]	OMA
NV2t018378001.1	biological_process	GO:0008340	determination of adult lifespan	"The pathways that regulate the duration of the adult phase of the life-cycle of an animal." [PMID:25561524, PMID:273723695, PMID:3424805]	OMA
NV2t018378001.1	biological_process	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t018378001.1	biological_process	GO:0009205	purine ribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t018378001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t018378001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t018378001.1	biological_process	GO:0010508	positive regulation of autophagy	"Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0010639	negative regulation of organelle organization	"Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0010738	regulation of protein kinase A signaling	"Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0010955	negative regulation of protein processing	"Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0014041	regulation of neuron maturation	"Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef]	OMA
NV2t018378001.1	biological_process	GO:0016242	negative regulation of macroautophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]	OMA
NV2t018378001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t018378001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t018378001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t018378001.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	OMA
NV2t018378001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0032091	negative regulation of protein binding	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0032092	positive regulation of protein binding	"Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0034260	negative regulation of GTPase activity	"Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649]	OMA
NV2t018378001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0035640	exploration behavior	"The specific behavior of an organism in response to a novel environment or stimulus." [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169]	OMA
NV2t018378001.1	biological_process	GO:0035751	regulation of lysosomal lumen pH	"Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:rph]	OMA
NV2t018378001.1	biological_process	GO:0040012	regulation of locomotion	"Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]	OMA
NV2t018378001.1	biological_process	GO:0043068	positive regulation of programmed cell death	"Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	OMA
NV2t018378001.1	biological_process	GO:0043406	positive regulation of MAP kinase activity	"Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t018378001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t018378001.1	biological_process	GO:0048312	intracellular distribution of mitochondria	"Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid]	OMA
NV2t018378001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0050848	regulation of calcium-mediated signaling	"Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai]	OMA
NV2t018378001.1	biological_process	GO:0051900	regulation of mitochondrial depolarization	"Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]	OMA
NV2t018378001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	OMA
NV2t018378001.1	biological_process	GO:0060079	excitatory postsynaptic potential	"A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef]	OMA
NV2t018378001.1	biological_process	GO:0060159	regulation of dopamine receptor signaling pathway	"Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]	OMA
NV2t018378001.1	biological_process	GO:0060628	regulation of ER to Golgi vesicle-mediated transport	"Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t018378001.1	biological_process	GO:0070973	protein localization to endoplasmic reticulum exit site	"A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0070997	obsolete neuron death	"OBSOLETE. The process of cell death in a neuron." [GOC:BHF, GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t018378001.1	biological_process	GO:0072593	reactive oxygen species metabolic process	"The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah]	OMA
NV2t018378001.1	biological_process	GO:0090066	regulation of anatomical structure size	"Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0090317	negative regulation of intracellular protein transport	"Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:0098815	modulation of excitatory postsynaptic potential	"Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dos]	OMA
NV2t018378001.1	biological_process	GO:0099175	regulation of postsynapse organization	"Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t018378001.1	biological_process	GO:1901215	obsolete negative regulation of neuron death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t018378001.1	biological_process	GO:1902692	regulation of neuroblast proliferation	"Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496]	OMA
NV2t018378001.1	biological_process	GO:1903206	obsolete negative regulation of hydrogen peroxide-induced cell death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14749723, PMID:24252804]	OMA
NV2t018378001.1	biological_process	GO:1903351	cellular response to dopamine	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]	OMA
NV2t018378001.1	biological_process	GO:1903649	obsolete regulation of cytoplasmic transport	"OBSOLETE. Any process that modulates the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409]	OMA
NV2t018378001.1	biological_process	GO:2000172	regulation of branching morphogenesis of a nerve	"Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]	OMA
NV2t018378001.1	biological_process	GO:2000300	regulation of synaptic vesicle exocytosis	"Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]	OMA
NV2t018378001.1	biological_process	GO:2000785	regulation of autophagosome assembly	"Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t018378001.1	biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t018378001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t018378001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t018378001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t018378001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t018378001.1	cellular_component	GO:0005798	Golgi-associated vesicle	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]	OMA
NV2t018378001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018378001.1	cellular_component	GO:0005902	microvillus	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]	OMA
NV2t018378001.1	cellular_component	GO:0016234	inclusion body	"A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]	OMA
NV2t018378001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t018378001.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t018378001.1	cellular_component	GO:0032473	cytoplasmic side of mitochondrial outer membrane	"The external (cytoplasmic) face of the mitochondrial outer membrane." [GOC:mah]	OMA
NV2t018378001.1	cellular_component	GO:0043204	perikaryon	"The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl]	OMA
NV2t018378001.1	cellular_component	GO:0044753	amphisome	"Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]	OMA
NV2t018378001.1	cellular_component	GO:0044754	autolysosome	"A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome or amphisome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases." [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921, PMID:24657946]	OMA
NV2t018378001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t018378001.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	OMA
NV2t018378001.1	cellular_component	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	OMA
NV2t018378001.1	cellular_component	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	OMA
NV2t018378001.1	cellular_component	GO:0120111	neuron projection cytoplasm	"All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha]	OMA
NV2t018378001.1	cellular_component	GO:1990909	Wnt signalosome	"A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]	OMA
NV2t018378001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t018378001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t018378001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018378001.1	molecular_function	GO:0004706	JUN kinase kinase kinase activity	"Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf]	OMA
NV2t018378001.1	molecular_function	GO:0004722	protein serine/threonine phosphatase activity	"Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]	OMA
NV2t018378001.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	OMA
NV2t018378001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t018378001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018378001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018378001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018378001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018378001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t018378001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t018378001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t018378001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t018378001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t018378001.1	molecular_function	GO:0044325	transmembrane transporter binding	"Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372]	OMA
NV2t018378001.1	molecular_function	GO:0051018	protein kinase A binding	"Binding to a protein kinase A." [GOC:ai]	OMA
NV2t018379001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t018380001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t018381001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t018381001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t018381001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t018381001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t018381001.1	biological_process	GO:0097428	protein maturation by iron-sulfur cluster transfer	"The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]	PANTHER
NV2t018381001.1	biological_process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	"Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]	OMA
NV2t018381001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018381001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018381001.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t018381001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t018381001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t018381001.1	molecular_function	GO:0016922	nuclear receptor binding	"Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974]	OMA
NV2t018381002.1	biological_process	GO:0097428	protein maturation by iron-sulfur cluster transfer	"The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]	PANTHER
NV2t018381003.1	biological_process	GO:0097428	protein maturation by iron-sulfur cluster transfer	"The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977]	PANTHER
NV2t018384001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t018384001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t018384001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t018384001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t018384001.1	biological_process	GO:0030865	cortical cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018384001.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	OMA
NV2t018384001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	OMA
NV2t018384001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	PANTHER
NV2t018384001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t018384001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018384001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t018384001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t018384001.1	cellular_component	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t018384001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018384001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018384001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018384001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018384001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t018385001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018385001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018385002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018385002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t018386001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018386002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018386003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018386004.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018386005.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018388001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018388001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t018388001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t018388001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018388001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t018388001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018389001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018393001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t018393001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018393001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t018393001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t018393001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018393001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018393001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t018395001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018397001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t018397001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t018397001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018397001.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	OMA
NV2t018397001.1	biological_process	GO:0008366	axon ensheathment	"Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]	OMA
NV2t018397001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t018397001.1	biological_process	GO:0015919	peroxisomal membrane transport	"The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai]	OMA
NV2t018397001.1	biological_process	GO:0019217	regulation of fatty acid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]	OMA
NV2t018397001.1	biological_process	GO:0031328	positive regulation of cellular biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t018397001.1	biological_process	GO:0031331	positive regulation of cellular catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t018397001.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	OMA
NV2t018397001.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t018397001.1	biological_process	GO:0046889	positive regulation of lipid biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]	OMA
NV2t018397001.1	biological_process	GO:0050996	positive regulation of lipid catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]	OMA
NV2t018397001.1	biological_process	GO:0062013	positive regulation of small molecule metabolic process	"Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t018397001.1	biological_process	GO:0106027	neuron projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923]	OMA
NV2t018397001.1	biological_process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	"Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804]	OMA
NV2t018397001.1	biological_process	GO:1905039	carboxylic acid transmembrane transport	"The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]	OMA
NV2t018397001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t018397001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018397001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t018397001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018397001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t018397001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t018397001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t018397001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t018397001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t018397001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t018397001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t018398001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	PANTHER
NV2t018399001.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	OMA
NV2t018399001.1	biological_process	GO:0099536	synaptic signaling	"Cell-cell signaling to, from or within a synapse." [GOC:dos]	PANTHER
NV2t018399001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018399001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018399001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018399001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t018401001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018401001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018401001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018401001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t018401001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t018402001.1	biological_process	GO:0090068	positive regulation of cell cycle process	"Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t018402001.1	biological_process	GO:1901987	regulation of cell cycle phase transition	"Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]	OMA
NV2t018402001.1	biological_process	GO:1901987	regulation of cell cycle phase transition	"Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]	PANTHER
NV2t018402001.1	biological_process	GO:2000105	positive regulation of DNA-templated DNA replication	"Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication." [GOC:mah]	OMA
NV2t018402001.1	cellular_component	GO:0031431	Dbf4-dependent protein kinase complex	"A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100]	OMA
NV2t018402001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t018402001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018402001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018402001.1	molecular_function	GO:0043539	protein serine/threonine kinase activator activity	"Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]	OMA
NV2t018403001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018403001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018403001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018405001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018405001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t018405001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t018405001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t018405001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t018405001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t018405001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018405001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018409001.1	biological_process	GO:0006637	acyl-CoA metabolic process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]	OMA
NV2t018409001.1	biological_process	GO:0006656	phosphatidylcholine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732]	OMA
NV2t018409001.1	biological_process	GO:0007589	body fluid secretion	"The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t018409001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	OMA
NV2t018409001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t018409001.1	biological_process	GO:0048732	gland development	"The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]	OMA
NV2t018409001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t018409001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018409001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t018409001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t018409001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018411001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018411001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018413001.1	biological_process	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	"The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020]	PANTHER
NV2t018413001.1	biological_process	GO:0042182	ketone catabolic process	"The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]	OMA
NV2t018413001.1	biological_process	GO:0046185	aldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t018413001.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t018413001.1	biological_process	GO:1901617	organic hydroxy compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t018413001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018413001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t018416001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018416001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018416001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018416001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018416001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018419001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t018419001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018419002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t018419002.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t018419002.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t018419002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t018419002.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t018419002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018419002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018419002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018420001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018420001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t018420001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	PANTHER
NV2t018422001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t018422001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018422001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t018422001.1	biological_process	GO:0022604	regulation of cell morphogenesis	"Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete]	OMA
NV2t018422001.1	biological_process	GO:0030177	positive regulation of Wnt signaling pathway	"Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t018422001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	OMA
NV2t018422001.1	biological_process	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	"The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism." [GOC:mah]	PANTHER
NV2t018422001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018422001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018422001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t018422001.1	molecular_function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341]	OMA
NV2t018423001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018423001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t018423001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t018425001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t018425001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t018425001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018425001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t018426001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t018428001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t018428001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018430001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t018430001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018430001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t018430001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t018430001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018430002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018430002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t018430002.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t018431001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t018431001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018431001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t018431001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t018431001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018432001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t018432001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018432002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018433001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018433001.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t018433001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018433001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t018433001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t018435001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018435001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018440001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t018440001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t018441001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t018441001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018442001.1	biological_process	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]	OMA
NV2t018442001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t018442001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t018442001.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	PANTHER
NV2t018442001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t018442001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018442001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t018442001.1	molecular_function	GO:0004535	poly(A)-specific ribonuclease activity	"Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]	OMA
NV2t018442001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018442001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018442002.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	InterPro
NV2t018442002.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	PANTHER
NV2t018442002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018442002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018442003.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	PANTHER
NV2t018442003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018442003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018442004.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	InterPro
NV2t018442004.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	PANTHER
NV2t018442004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018442004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018442005.1	cellular_component	GO:0031251	PAN complex	"A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]	PANTHER
NV2t018442005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018444001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t018444001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018444001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018444001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018444001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018444001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018444001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018444001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018445001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018445001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018445001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t018445002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018445002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018446001.1	biological_process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	InterPro
NV2t018446001.1	cellular_component	GO:0048500	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	InterPro
NV2t018446001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018446001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t018446002.1	biological_process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	InterPro
NV2t018446002.1	cellular_component	GO:0048500	signal recognition particle	"A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]	InterPro
NV2t018446002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018446002.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t018447001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	InterPro
NV2t018447001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t018447001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t018447001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t018447001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t018447001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t018447001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t018448001.1	molecular_function	GO:0019789	SUMO transferase activity	"Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250]	OMA
NV2t018448001.1	molecular_function	GO:0061656	SUMO conjugating enzyme activity	"Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph]	PANTHER
NV2t018450001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t018450001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018450001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018450001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018451001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018451001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t018451001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018451002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018451002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t018451002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018452001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018452002.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t018452002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t018452002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018452002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t018453001.1	molecular_function	GO:0070694	deoxyribonucleoside 5'-monophosphate N-glycosidase activity	"Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base." [GOC:ab, PMID:17234634]	PANTHER
NV2t018453002.1	biological_process	GO:0009125	nucleoside monophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t018453002.1	biological_process	GO:0009162	deoxyribonucleoside monophosphate metabolic process	"The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t018453002.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t018453002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018453002.1	molecular_function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	"Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]	OMA
NV2t018453002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t018453002.1	molecular_function	GO:0070694	deoxyribonucleoside 5'-monophosphate N-glycosidase activity	"Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base." [GOC:ab, PMID:17234634]	InterPro
NV2t018453002.1	molecular_function	GO:0070694	deoxyribonucleoside 5'-monophosphate N-glycosidase activity	"Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base." [GOC:ab, PMID:17234634]	PANTHER
NV2t018454001.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454002.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454003.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454004.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454005.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454006.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454007.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454008.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454009.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454010.1	biological_process	GO:0090314	positive regulation of protein targeting to membrane	"Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb]	PANTHER
NV2t018454011.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018454012.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018454012.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018455001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018456001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018456001.1	cellular_component	GO:1990513	CLOCK-BMAL transcription complex	"Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms." [GOC:bhm, PMID:23229515]	PANTHER
NV2t018456001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018465001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t018465001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t018465001.1	cellular_component	GO:0000790	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	PANTHER
NV2t018465001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018465001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018465001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018465001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018465001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018465002.1	cellular_component	GO:0000790	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	PANTHER
NV2t018465002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018465002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018465003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018465003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t018465004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018465004.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t018467001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t018467001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t018467001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	InterPro
NV2t018467001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t018467001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t018467001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t018469001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018469001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t018470001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018470001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t018470001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018470002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018470002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018471001.1	molecular_function	GO:0016231	beta-N-acetylglucosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]	PANTHER
NV2t018471001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t018471002.1	molecular_function	GO:0016231	beta-N-acetylglucosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]	PANTHER
NV2t018471002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t018471003.1	molecular_function	GO:0016231	beta-N-acetylglucosaminidase activity	"Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]	PANTHER
NV2t018471003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t018472001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t018472001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018472001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t018472001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t018472001.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	InterPro
NV2t018472001.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	PANTHER
NV2t018473001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018473001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018473001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018473001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018473001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018473002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018474001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t018474001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018474001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018474001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t018475001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t018475001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018475001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t018475001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018476001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	OMA
NV2t018476001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	PANTHER
NV2t018480001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t018482001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t018482001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t018482001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018482001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018482001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018486001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018486002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018486002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t018487001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018487001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t018487002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018488001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t018489001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018492001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t018492001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t018492001.1	biological_process	GO:0008608	attachment of spindle microtubules to kinetochore	"The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137]	OMA
NV2t018492001.1	biological_process	GO:0010212	response to ionizing radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]	OMA
NV2t018492001.1	biological_process	GO:0045739	positive regulation of DNA repair	"Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators]	OMA
NV2t018492001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	OMA
NV2t018492001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	OMA
NV2t018492001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t018492001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t018492001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t018492001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t018492002.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t018493001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018493001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t018493001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018496001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t018496001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t018496001.1	molecular_function	GO:0045134	UDP phosphatase activity	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]	PANTHER
NV2t018496002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t018496002.1	molecular_function	GO:0045134	UDP phosphatase activity	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]	PANTHER
NV2t018497001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t018497001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t018497001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018497001.1	molecular_function	GO:0019001	guanyl nucleotide binding	"Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t018497001.1	molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	"Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw]	InterPro
NV2t018497001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t018498001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t018498001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018500001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t018500001.1	biological_process	GO:0007007	inner mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018500001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t018500001.1	biological_process	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	OMA
NV2t018500001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t018500001.1	biological_process	GO:0044743	protein transmembrane import into intracellular organelle	"The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]	OMA
NV2t018500001.1	biological_process	GO:0045039	protein insertion into mitochondrial inner membrane	"The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." [GOC:mcc, GOC:vw, PMID:18672008]	PANTHER
NV2t018500001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	OMA
NV2t018500001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t018500001.1	biological_process	GO:0090151	establishment of protein localization to mitochondrial membrane	"The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t018500001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t018500001.1	biological_process	GO:2000379	positive regulation of reactive oxygen species metabolic process	"Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]	OMA
NV2t018500001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t018501001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t018501001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t018501001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t018501001.1	molecular_function	GO:0004651	polynucleotide 5'-phosphatase activity	"Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33]	PANTHER
NV2t018501001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t018502001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t018502001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018502001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018502002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018502003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018505001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t018505001.1	biological_process	GO:0044319	wound healing, spreading of cells	"The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface." [GOC:jl]	OMA
NV2t018505001.1	biological_process	GO:0045807	positive regulation of endocytosis	"Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]	OMA
NV2t018505001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t018505001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018505001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t018505001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018505001.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t018507001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t018507001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t018507001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t018507001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t018507001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t018507001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t018507001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018507001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018507001.1	molecular_function	GO:0008469	histone arginine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [PMID:8002954]	OMA
NV2t018507001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t018507001.1	molecular_function	GO:0035241	protein-arginine omega-N monomethyltransferase activity	"Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine." [EC:2.1.1.321, PMID:14705965, RESID:AA0069]	OMA
NV2t018507001.1	molecular_function	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965]	OMA
NV2t018507001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t018507001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t018507001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t018507002.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	InterPro
NV2t018509001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018509001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t018509001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t018509001.1	molecular_function	GO:0008422	beta-glucosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21, PMID:12594539]	PANTHER
NV2t018510001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t018513001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018513001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t018513001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t018513001.1	biological_process	GO:0008585	female gonad development	"The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t018513001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018513001.1	biological_process	GO:0051292	nuclear pore complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah]	OMA
NV2t018513001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t018513001.1	cellular_component	GO:0031080	nuclear pore outer ring	"A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t018513001.1	cellular_component	GO:0034399	nuclear periphery	"The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]	OMA
NV2t018513001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t018513001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t018515001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t018515001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018517001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018517001.1	molecular_function	GO:0001609	G protein-coupled adenosine receptor activity	"Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]	OMA
NV2t018517001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018517002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018517002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018517003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018517003.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018517004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018517004.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018517005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018517005.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018519001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t018519001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018519001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018521001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018522001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t018524001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t018530001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t018530001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t018530001.1	biological_process	GO:1903351	cellular response to dopamine	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]	OMA
NV2t018530001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018530001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018530001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018530001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t018531001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t018531001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t018532001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018533001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t018535001.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	PANTHER
NV2t018537001.1	biological_process	GO:0008218	bioluminescence	"The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732]	InterPro
NV2t018538001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t018538001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018538001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018538001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018546001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t018546001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018546001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018551001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018551001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018551002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t018551002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018552001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t018552001.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	PANTHER
NV2t018552002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t018552002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t018552002.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	PANTHER
NV2t018552003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t018552003.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	PANTHER
NV2t018552004.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t018552004.1	molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	"Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]	PANTHER
NV2t018555001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	OMA
NV2t018555001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t018555001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t018555001.1	cellular_component	GO:0097539	ciliary transition fiber	"A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium)." [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827]	PANTHER
NV2t018557001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t018557001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018557001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018558001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018560001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018560001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t018560001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t018560001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t018560001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018560001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018560001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018560002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018561001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018561001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018561001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t018561001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t018561001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t018561001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018561002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018561002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018561002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018562001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018562001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018562001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t018562001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t018562001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t018562001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t018562001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018563001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t018563001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018566001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t018566001.1	biological_process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, Wikipedia:Caspase]	OMA
NV2t018566001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t018566001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t018566001.1	biological_process	GO:0071495	cellular response to endogenous stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]	OMA
NV2t018566001.1	biological_process	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	OMA
NV2t018566001.1	biological_process	GO:0097202	activation of cysteine-type endopeptidase activity	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:21726810]	OMA
NV2t018566001.1	cellular_component	GO:0043293	apoptosome	"A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [GOC:mtg_apoptosis, PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137]	OMA
NV2t018566001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018566001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018566001.1	molecular_function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	"Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process." [GOC:mah, GOC:mtg_apoptosis]	OMA
NV2t018566001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t018566001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t018566001.1	molecular_function	GO:0043531	ADP binding	"Binding to ADP, adenosine 5'-diphosphate." [GOC:jl]	InterPro
NV2t018566002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t018566002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018566002.1	molecular_function	GO:0043531	ADP binding	"Binding to ADP, adenosine 5'-diphosphate." [GOC:jl]	InterPro
NV2t018567001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t018567001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t018567001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018567001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t018569001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018569001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018569001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018570001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t018570001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t018570001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t018572001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018573001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t018573001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t018573001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t018573001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t018574001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018574001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t018574001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018574001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018574001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t018574001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t018574001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t018574001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t018574001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t018574001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t018575001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	InterPro
NV2t018575001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018575001.1	cellular_component	GO:0042720	mitochondrial inner membrane peptidase complex	"Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]	PANTHER
NV2t018576001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018578001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t018578001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t018580001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t018580001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018580001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t018580001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t018581001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018581001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018581001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018584001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t018584001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018586001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t018588001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018588001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018588001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t018588001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t018588001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t018588001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t018588002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018589001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018589001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018589001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018589002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t018589002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018589002.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t018589002.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018589002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t018590001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t018590002.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t018590002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018590002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t018590002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018590002.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t018590002.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t018590002.1	cellular_component	GO:1990351	transporter complex	"A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]	OMA
NV2t018597001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018597001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018599001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t018599001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t018599001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t018599001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018599001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018599001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t018601001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t018601001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018601001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018601001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018602001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018602001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t018602001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t018603001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018603001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018603001.1	molecular_function	GO:0051184	obsolete cofactor transmembrane transporter activity	"OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]	PANTHER
NV2t018604001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018604001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t018605001.1	biological_process	GO:2000145	regulation of cell motility	"Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah]	OMA
NV2t018605001.1	biological_process	GO:2000146	negative regulation of cell motility	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah]	PANTHER
NV2t018609001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018609001.1	molecular_function	GO:0051184	obsolete cofactor transmembrane transporter activity	"OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]	PANTHER
NV2t018611001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018611001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018611001.1	molecular_function	GO:0051184	obsolete cofactor transmembrane transporter activity	"OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]	PANTHER
NV2t018613001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018614001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018615001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t018615001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	OMA
NV2t018615001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	OMA
NV2t018615001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	PANTHER
NV2t018615001.1	molecular_function	GO:0032977	membrane insertase activity	"Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]	OMA
NV2t018616001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616005.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616006.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616007.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616008.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616009.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616010.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616011.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018616012.1	cellular_component	GO:0031519	PcG protein complex	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]	PANTHER
NV2t018616013.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018618001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t018618001.1	biological_process	GO:0007338	single fertilization	"The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu]	OMA
NV2t018618001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018618001.1	cellular_component	GO:0097731	9+0 non-motile cilium	"A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:22118931]	OMA
NV2t018618001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t018618001.1	molecular_function	GO:0120160	intraciliary transport particle A binding	"Binding to an intraciliary transport particle A (IFT A) complex." [PMID:20889716]	PANTHER
NV2t018622001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t018622001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018622001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018622001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t018623001.1	biological_process	GO:0000958	mitochondrial mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]	OMA
NV2t018623001.1	biological_process	GO:0000965	mitochondrial RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]	OMA
NV2t018623001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t018623001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t018623001.1	biological_process	GO:0031331	positive regulation of cellular catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t018623001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t018623001.1	biological_process	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	OMA
NV2t018623001.1	biological_process	GO:0070584	obsolete mitochondrion morphogenesis	"OBSOLETE. The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah]	OMA
NV2t018623001.1	biological_process	GO:0071025	RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs." [GOC:dgf, GOC:krc, PMID:18644474]	OMA
NV2t018623001.1	cellular_component	GO:0000178	exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t018623001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018623001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t018623001.1	cellular_component	GO:0045025	mitochondrial degradosome	"A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer." [PMID:10397341, PMID:9829834]	PANTHER
NV2t018623001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t018623001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018623001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t018623001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t018623001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018623001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018623001.1	molecular_function	GO:0016817	hydrolase activity, acting on acid anhydrides	"Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]	OMA
NV2t018623001.1	molecular_function	GO:0034458	3'-5' RNA helicase activity	"Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis." [GOC:jp]	OMA
NV2t018624001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t018624001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018624001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t018624001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t018624001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t018624001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t018625001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018625001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018625001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018625001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018626001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018626001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018626001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018626001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018627001.1	biological_process	GO:0042554	superoxide anion generation	"The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]	PANTHER
NV2t018627001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018627001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t018627001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t018629001.1	biological_process	GO:0009312	oligosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t018629001.1	biological_process	GO:0018279	protein N-linked glycosylation via asparagine	"The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]	OMA
NV2t018629001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t018629001.1	cellular_component	GO:0005795	Golgi stack	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]	OMA
NV2t018629001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018629001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t018629001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t018629001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t018629001.1	molecular_function	GO:0140103	catalytic activity, acting on a glycoprotein	"Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t018631001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018631001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t018632001.1	biological_process	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	PANTHER
NV2t018632002.1	biological_process	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	PANTHER
NV2t018632003.1	biological_process	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	PANTHER
NV2t018632004.1	biological_process	GO:0043069	negative regulation of programmed cell death	"Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	PANTHER
NV2t018633001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t018633001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t018633001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t018633001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t018633001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018633001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t018633001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	PANTHER
NV2t018633002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t018633002.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t018633002.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	PANTHER
NV2t018634001.1	biological_process	GO:0006520	amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]	OMA
NV2t018634001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t018634001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t018634001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	PANTHER
NV2t018634001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018634001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t018634002.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	PANTHER
NV2t018634002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018635001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t018635001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t018635001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018635001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t018637001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018639001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018639001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018639001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018639001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018644001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t018644001.1	biological_process	GO:0046700	obsolete heterocycle catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]	OMA
NV2t018644001.1	biological_process	GO:1901361	organic cyclic compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t018644001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t018644001.1	molecular_function	GO:0004037	allantoicase activity	"Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11016]	InterPro
NV2t018644001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t018645001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018645001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018645002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018645002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018649001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t018649001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018649002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018649003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018650001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	InterPro
NV2t018651001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t018651001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t018651001.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t018651001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t018651001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t018651001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t018651001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018651001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t018651001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t018651001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t018651001.1	molecular_function	GO:0016798	hydrolase activity, acting on glycosyl bonds	"Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]	InterPro
NV2t018654001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t018654001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t018658001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t018658001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t018658001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t018658001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	OMA
NV2t018658001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018658001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018658001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t018658002.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t018658002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018658002.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t018659001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018659001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018659001.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t018659001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t018659001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018659001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t018660001.1	biological_process	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	OMA
NV2t018660001.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t018660001.1	cellular_component	GO:0005798	Golgi-associated vesicle	"Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]	OMA
NV2t018660001.1	cellular_component	GO:0005801	cis-Golgi network	"The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194]	OMA
NV2t018660001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t018660001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018660001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t018662001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018662001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018662001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018665001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018665001.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t018665002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018665002.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t018666001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t018666001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t018666001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t018666001.1	biological_process	GO:0140374	antiviral innate immune response	"A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [PMID:31006531]	OMA
NV2t018666001.1	biological_process	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t018666001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t018666001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t018666001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t018666001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t018666001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t018666001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t018666001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018666001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018666002.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t018666003.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t018667001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018669001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018670001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018670002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018672001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018672001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018672001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018674001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018674001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018674001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018674002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018674002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018674002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018677001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018677001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018677001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018683001.1	cellular_component	GO:0000790	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	PANTHER
NV2t018683001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018684001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t018684001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t018684001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t018684001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t018684001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t018684001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018684001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018693001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018693001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018693001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t018693001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018695001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t018695001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018695001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018695001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t018695001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t018698001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t018698001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t018698002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t018698002.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t018698003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t018698003.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t018699001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018699001.1	biological_process	GO:0033528	S-methylmethionine cycle	"A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441]	PANTHER
NV2t018699002.1	biological_process	GO:0033528	S-methylmethionine cycle	"A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441]	PANTHER
NV2t018701001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t018701001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t018702001.1	biological_process	GO:0006575	cellular modified amino acid metabolic process	"The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t018702001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018702001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t018702001.1	biological_process	GO:0033528	S-methylmethionine cycle	"A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441]	PANTHER
NV2t018702001.1	molecular_function	GO:0008172	S-methyltransferase activity	"Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai]	OMA
NV2t018702001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018702001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t018703001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t018704001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t018704001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t018704001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t018704001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t018704001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t018704001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018704001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t018705001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t018705001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018705002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t018705002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018705003.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t018705003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018706001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t018706001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t018706001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018706001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t018706002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018706003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018706004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018706005.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018706006.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018706008.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018706009.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018707001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t018707001.1	biological_process	GO:0006997	nucleus organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]	OMA
NV2t018707001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t018707001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t018707001.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t018707001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018707001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t018707001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t018707001.1	cellular_component	GO:0044614	nuclear pore cytoplasmic filaments	"Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t018707001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018707001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018707001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	InterPro
NV2t018707001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t018707001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	OMA
NV2t018708001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018708004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018708005.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018710001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018711001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018713001.1	biological_process	GO:0033169	obsolete histone H3-K9 demethylation	"OBSOLETE. The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone." [GOC:mah]	InterPro
NV2t018715001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t018715002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t018716001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t018716001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t018716001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t018716001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t018718001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t018718002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t018718003.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t018719001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t018720001.1	biological_process	GO:0071375	cellular response to peptide hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]	PANTHER
NV2t018720001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t018720001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t018720001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t018720001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t018720001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t018720001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t018723001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018723001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t018723001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018723001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018723001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t018723001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018723001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018725001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018725001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018725001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018725001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018725001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018729001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018729001.1	biological_process	GO:0048598	embryonic morphogenesis	"The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu]	PANTHER
NV2t018729001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018730001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018730001.1	molecular_function	GO:0015929	hexosaminidase activity	"Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544]	InterPro
NV2t018730002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018730002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t018730002.1	molecular_function	GO:0015929	hexosaminidase activity	"Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544]	InterPro
NV2t018730002.1	molecular_function	GO:0015929	hexosaminidase activity	"Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544]	OMA
NV2t018732001.1	molecular_function	GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	"Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine." [PMID:19014349, PMID:31869331, RHEA:27606]	InterPro
NV2t018732002.1	molecular_function	GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	"Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine." [PMID:19014349, PMID:31869331, RHEA:27606]	InterPro
NV2t018732003.1	biological_process	GO:0006659	phosphatidylserine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732]	OMA
NV2t018732003.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018732003.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t018732003.1	molecular_function	GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	"Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine." [PMID:19014349, PMID:31869331, RHEA:27606]	InterPro
NV2t018735001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018735001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018735001.1	molecular_function	GO:0051184	obsolete cofactor transmembrane transporter activity	"OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]	PANTHER
NV2t018738001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018738001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018738001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018743001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018743001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018743001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018743001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018743001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018745001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t018745001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018745001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018745001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t018748001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t018748001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018748001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018748001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t018749001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t018749001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018750002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t018750002.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t018750002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018750002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018750003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t018750003.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t018750003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t018750003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t018750003.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t018750003.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t018750003.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t018750003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018750003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018750003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018750003.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t018750003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018750004.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t018750004.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t018750004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018750004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018750005.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t018750005.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t018750005.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t018750005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018750005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018750005.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018750006.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t018750006.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t018750006.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018753001.1	biological_process	GO:0006072	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t018753001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t018753001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t018753001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	OMA
NV2t018753001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	InterPro
NV2t018753001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018753001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t018753001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t018753001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018754001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	PANTHER
NV2t018754001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	InterPro
NV2t018755001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018755001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t018755001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	OMA
NV2t018755001.1	biological_process	GO:0046835	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	PANTHER
NV2t018755001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t018755001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018755001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t018755001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018755001.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t018758001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t018758001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t018758001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t018758001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t018758001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t018760001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	OMA
NV2t018760001.1	biological_process	GO:0042246	tissue regeneration	"The regrowth of lost or destroyed tissues." [GOC:curators]	OMA
NV2t018760001.1	biological_process	GO:0046716	muscle cell cellular homeostasis	"The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]	OMA
NV2t018760001.1	biological_process	GO:0060538	skeletal muscle organ development	"The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph]	OMA
NV2t018760001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t018760001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t018760001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018760001.1	molecular_function	GO:0042285	xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t018760001.1	molecular_function	GO:0042285	xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	PANTHER
NV2t018760001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t018760002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018760002.1	molecular_function	GO:0042285	xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	PANTHER
NV2t018760003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018760003.1	molecular_function	GO:0042285	xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	PANTHER
NV2t018760004.1	molecular_function	GO:0042285	xylosyltransferase activity	"Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	PANTHER
NV2t018762001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t018762001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018762002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t018762002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t018763001.1	biological_process	GO:0019367	fatty acid elongation, saturated fatty acid	"Elongation of a saturated fatty acid chain." [GOC:mah]	OMA
NV2t018763001.1	biological_process	GO:0019368	fatty acid elongation, unsaturated fatty acid	"Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah]	OMA
NV2t018763001.1	biological_process	GO:0030148	sphingolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t018763001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	OMA
NV2t018763001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t018763001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018763001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018763001.1	molecular_function	GO:0009922	fatty acid elongase activity	"Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit." [PMID:16564093, PMID:19763486, RHEA:32727]	OMA
NV2t018764001.1	biological_process	GO:0019367	fatty acid elongation, saturated fatty acid	"Elongation of a saturated fatty acid chain." [GOC:mah]	OMA
NV2t018764001.1	biological_process	GO:0019368	fatty acid elongation, unsaturated fatty acid	"Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah]	OMA
NV2t018764001.1	biological_process	GO:0030148	sphingolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t018764001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	OMA
NV2t018764001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t018764001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018764001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018764001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t018764001.1	cellular_component	GO:0097447	dendritic tree	"The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]	OMA
NV2t018764001.1	molecular_function	GO:0009922	fatty acid elongase activity	"Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit." [PMID:16564093, PMID:19763486, RHEA:32727]	OMA
NV2t018764002.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t018764002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018764003.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t018764003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018764004.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t018764004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018765001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t018765001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t018765001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018765002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t018768001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t018768001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018768001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t018770001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018770001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018770001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018772001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t018772001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018772001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018772002.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t018772002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018775001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018775001.1	molecular_function	GO:0051184	obsolete cofactor transmembrane transporter activity	"OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]	PANTHER
NV2t018778001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t018778001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018778001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	InterPro
NV2t018778001.1	biological_process	GO:0007080	mitotic metaphase chromosome alignment	"A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division." [ISBN:0815316194]	OMA
NV2t018778001.1	biological_process	GO:0010458	exit from mitosis	"The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]	OMA
NV2t018778001.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t018778001.1	biological_process	GO:0031468	nuclear membrane reassembly	"The reformation of the nuclear membranes following their breakdown in the context of a normal process." [GOC:mah]	OMA
NV2t018778001.1	biological_process	GO:0032509	endosome transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]	OMA
NV2t018778001.1	biological_process	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	"The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]	PANTHER
NV2t018778001.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t018778001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t018778001.1	biological_process	GO:0044000	obsolete movement in host	"OBSOLETE. The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]	OMA
NV2t018778001.1	biological_process	GO:0060548	obsolete negative regulation of cell death	"OBSOLETE. Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t018778001.1	biological_process	GO:0061952	midbody abscission	"The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells." [PMID:12737809, PMID:29903934]	OMA
NV2t018778001.1	biological_process	GO:0071168	protein localization to chromatin	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]	OMA
NV2t018778001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t018778001.1	biological_process	GO:1901673	regulation of mitotic spindle assembly	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]	OMA
NV2t018778001.1	biological_process	GO:1902774	late endosome to lysosome transport	"The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442]	OMA
NV2t018778001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t018778001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t018778001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t018778001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t018778001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t018778001.1	cellular_component	GO:0005771	multivesicular body	"A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]	OMA
NV2t018778001.1	cellular_component	GO:0005828	kinetochore microtubule	"Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]	OMA
NV2t018778001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t018778001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t018778001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t018778001.1	cellular_component	GO:0036452	ESCRT complex	"An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536]	OMA
NV2t018778001.1	cellular_component	GO:0044753	amphisome	"Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]	OMA
NV2t018778001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t018779001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	InterPro
NV2t018779001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t018779001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018779001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018779001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018779001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018779001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t018779002.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	InterPro
NV2t018779002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018779003.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	InterPro
NV2t018779003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018779004.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	InterPro
NV2t018779004.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018780001.1	biological_process	GO:0006301	postreplication repair	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh]	OMA
NV2t018780001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t018780001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018781001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t018781001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t018781001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	OMA
NV2t018781001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	PANTHER
NV2t018781001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018781001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t018781002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t018781002.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	PANTHER
NV2t018781003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t018781003.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	PANTHER
NV2t018782001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t018782001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018782001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018783001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018783001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018783001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t018783002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018783002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018783002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t018783003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018783003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018783003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018783003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t018785001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018785001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018785001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018785002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018785002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018785003.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018785003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018785004.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018785004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018785005.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018786001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018786001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018786001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t018787001.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t018787002.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	InterPro
NV2t018787002.1	biological_process	GO:0006096	glycolytic process	"The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis]	OMA
NV2t018787002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018787002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t018787002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t018787002.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t018788002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018789001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t018789001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018789001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t018789001.1	molecular_function	GO:0018773	acetylpyruvate hydrolase activity	"Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate." [EC:3.7.1.6, RHEA:16097]	PANTHER
NV2t018791001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018791001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t018791001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t018791001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t018791001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018791001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018791001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018791002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018791002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t018791002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018791002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018792001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t018792001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018792002.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t018792002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018793001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018793001.1	biological_process	GO:0140300	serine import into mitochondrion	"The process in which serine is transported from the cytosol into the mitochondrial matrix." [PMID:30442778]	OMA
NV2t018793001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	PANTHER
NV2t018793001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t018793001.1	molecular_function	GO:0015075	monoatomic ion transmembrane transporter activity	"Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018793001.1	molecular_function	GO:0022889	obsolete serine transmembrane transporter activity	"OBSOLETE. Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729, RHEA:35031]	OMA
NV2t018795001.1	biological_process	GO:0006525	arginine metabolic process	"The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]	OMA
NV2t018795001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t018795001.1	biological_process	GO:0006560	proline metabolic process	"The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t018795001.1	biological_process	GO:0009065	glutamine family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t018795001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t018795001.1	molecular_function	GO:0004587	ornithine aminotransferase activity	"Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde." [EC:2.6.1.13]	InterPro
NV2t018795001.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t018795001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018795001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t018795001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t018795001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	PANTHER
NV2t018796001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018796001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018796001.1	molecular_function	GO:0005215	transporter activity	"Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]	PANTHER
NV2t018796001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018798001.1	cellular_component	GO:0032426	stereocilium tip	"A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation." [GOC:ecd, GOC:krc, PMID:17021180, PMID:27565685]	PANTHER
NV2t018800001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t018800001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t018800001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018800001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	PANTHER
NV2t018802001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t018802001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t018802001.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t018802001.1	biological_process	GO:0051791	medium-chain fatty acid metabolic process	"The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolisms]	OMA
NV2t018802001.1	biological_process	GO:0051793	medium-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolism]	PANTHER
NV2t018802001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t018802001.1	molecular_function	GO:0034338	short-chain carboxylesterase activity	"Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp]	OMA
NV2t018803001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t018803001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t018803001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t018803001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t018805001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t018805002.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t018805003.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t018806001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t018806001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t018806001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	PANTHER
NV2t018806001.1	molecular_function	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	"Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63]	OMA
NV2t018807001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t018807001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t018807001.1	biological_process	GO:0006423	cysteinyl-tRNA aminoacylation	"The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t018807001.1	biological_process	GO:0006423	cysteinyl-tRNA aminoacylation	"The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t018807001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018807001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t018807001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t018807001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018807001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t018809001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t018812001.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t018812001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t018812001.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t018812001.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	PANTHER
NV2t018812001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t018812001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t018812001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t018815001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018815001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018815001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018818001.1	biological_process	GO:0000154	rRNA modification	"The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t018818001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t018818001.1	biological_process	GO:0001522	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule." [GOC:hjd, GOC:mah]	OMA
NV2t018818001.1	biological_process	GO:0040031	snRNA modification	"The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl]	OMA
NV2t018818001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t018818001.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	OMA
NV2t018818001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t018818001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	InterPro
NV2t018818001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t018818001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t018818001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t018818001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t018818001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t018818001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t018818001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t018818001.1	molecular_function	GO:0034513	box H/ACA snoRNA binding	"Binding to a box H/ACA small nucleolar RNA." [GOC:mah]	PANTHER
NV2t018820001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t018820001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t018820001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t018820001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t018820001.1	biological_process	GO:0007520	myoblast fusion	"A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]	OMA
NV2t018820001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t018820001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018820001.1	biological_process	GO:0044351	macropinocytosis	"An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size." [PMID:14732047]	OMA
NV2t018820001.1	biological_process	GO:0050766	positive regulation of phagocytosis	"Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]	OMA
NV2t018820001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018820001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018820001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t018820001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t018820001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018820001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t018820001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t018820001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t018820002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018820002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t018820003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t018820007.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t018821001.1	biological_process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	"An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]	OMA
NV2t018821001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t018821001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018821001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018821001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t018821001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t018821001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t018821001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018821001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t018821001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t018821001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t018821002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018821002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t018825001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018825001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018825001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018827001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018827001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018827001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018827001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018827001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t018831001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018831001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018831001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018832001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018832001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018833001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t018833001.1	molecular_function	GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	"Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine." [GOC:imk, PMID:19965768, RHEA:62520]	PANTHER
NV2t018833002.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t018833002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t018833002.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t018833002.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	OMA
NV2t018833002.1	molecular_function	GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	"Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine." [GOC:imk, PMID:19965768, RHEA:62520]	PANTHER
NV2t018834001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t018834001.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	OMA
NV2t018834001.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	PANTHER
NV2t018836001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t018836001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t018836001.1	biological_process	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t018836001.1	biological_process	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	OMA
NV2t018836001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t018836001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018836001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t018836001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t018836001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018836001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018836001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t018836001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t018836001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t018836001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t018836001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t018836002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018836002.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t018836002.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t018839001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t018839001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018839001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018839001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t018841001.1	biological_process	GO:0010960	magnesium ion homeostasis	"Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb]	OMA
NV2t018841001.1	biological_process	GO:0030026	intracellular manganese ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of manganese ions within a cell." [GOC:mah]	PANTHER
NV2t018842001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t018842001.1	biological_process	GO:0090136	epithelial cell-cell adhesion	"The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t018842001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t018842001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018842001.1	cellular_component	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	OMA
NV2t018842001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t018842001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t018842001.1	molecular_function	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	OMA
NV2t018842001.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	OMA
NV2t018842001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t018842001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t018844001.1	biological_process	GO:0006658	phosphatidylserine metabolic process	"The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t018844001.1	biological_process	GO:0007626	locomotory behavior	"The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]	OMA
NV2t018844001.1	biological_process	GO:0042219	cellular modified amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t018844001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t018844001.1	biological_process	GO:0046464	acylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]	OMA
NV2t018844001.1	biological_process	GO:0052651	monoacylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [PMID:25290914]	PANTHER
NV2t018844001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018844001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	OMA
NV2t018844001.1	molecular_function	GO:0008474	palmitoyl-(protein) hydrolase activity	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]	OMA
NV2t018846001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t018846001.1	biological_process	GO:0006024	glycosaminoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	OMA
NV2t018846001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t018846001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t018846001.1	biological_process	GO:0030166	proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]	OMA
NV2t018846001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	PANTHER
NV2t018846001.1	biological_process	GO:0097435	supramolecular fiber organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr]	OMA
NV2t018846001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t018846001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018846001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018846001.1	molecular_function	GO:0046525	xylosylprotein 4-beta-galactosyltransferase activity	"Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133]	OMA
NV2t018846001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t018847001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018847001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t018847001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t018847001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	PANTHER
NV2t018847001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t018847001.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t018847001.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	OMA
NV2t018847001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t018847001.1	biological_process	GO:0050766	positive regulation of phagocytosis	"Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]	OMA
NV2t018847001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t018847001.1	cellular_component	GO:0097733	photoreceptor cell cilium	"A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment." [GOC:cilia, Wikipedia:Photoreceptor_cell#Histology]	OMA
NV2t018847001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018847001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t018847001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	OMA
NV2t018847001.1	molecular_function	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t018848001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t018848001.1	biological_process	GO:2001022	obsolete positive regulation of response to DNA damage stimulus	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]	OMA
NV2t018848001.1	cellular_component	GO:0000793	condensed chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]	OMA
NV2t018848001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018848001.1	cellular_component	GO:0030915	Smc5-Smc6 complex	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]	PANTHER
NV2t018848001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t018849001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t018851001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t018851001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018852001.1	biological_process	GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	"Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]	PANTHER
NV2t018852001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018852002.1	biological_process	GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	"Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]	PANTHER
NV2t018852002.1	biological_process	GO:0031125	rRNA 3'-end processing	"Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah]	OMA
NV2t018852002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t018852002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018852002.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	InterPro
NV2t018852002.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t018852002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018852002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t018853001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t018853001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	InterPro
NV2t018853001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t018853001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t018853001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018853001.1	molecular_function	GO:0000700	mismatch base pair DNA N-glycosylase activity	"Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623]	OMA
NV2t018853001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t018853001.1	molecular_function	GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	"Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]	OMA
NV2t018853001.1	molecular_function	GO:0032357	oxidized purine DNA binding	"Binding to a DNA region containing an oxidized purine residue." [GOC:vk]	OMA
NV2t018853001.1	molecular_function	GO:0035485	adenine/guanine mispair binding	"Binding to a double-stranded DNA region containing an A/G mispair." [GOC:bf, GOC:jh]	PANTHER
NV2t018853001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t018855001.1	biological_process	GO:0090140	regulation of mitochondrial fission	"Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t018855001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018856001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018856001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018856001.1	molecular_function	GO:0045182	translation regulator activity	"Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]	InterPro
NV2t018857001.1	biological_process	GO:0002940	tRNA N2-guanine methylation	"The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337]	OMA
NV2t018857001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018857001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018857001.1	molecular_function	GO:0004809	obsolete tRNA (guanine-N2-)-methyltransferase activity	"OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32]	OMA
NV2t018857001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018857001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t018857001.1	molecular_function	GO:0160102	tRNA (guanine(10)-N2)-methyltransferase activity	"Catalysis of the reaction: guanosine(10) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.214]	InterPro
NV2t018859001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t018859001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t018859001.1	biological_process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	"Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]	OMA
NV2t018859001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t018859001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t018859001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t018859001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t018859001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t018859001.1	molecular_function	GO:0016922	nuclear receptor binding	"Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974]	OMA
NV2t018863001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018863001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	PANTHER
NV2t018863001.1	molecular_function	GO:0016803	ether hydrolase activity	"Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai]	OMA
NV2t018865001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t018865001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t018865001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t018865001.1	cellular_component	GO:0030687	preribosome, large subunit precursor	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]	PANTHER
NV2t018865001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t018866001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t018868001.1	molecular_function	GO:0140297	DNA-binding transcription factor binding	"Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018]	PANTHER
NV2t018869001.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	OMA
NV2t018869001.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	PANTHER
NV2t018869001.1	biological_process	GO:0046835	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t018869001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018869001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018869001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018869001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t018869001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t018869001.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t018869002.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	PANTHER
NV2t018869002.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t018870001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t018870001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t018870001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t018870001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t018870001.1	molecular_function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019]	PANTHER
NV2t018870002.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t018870002.1	molecular_function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019]	PANTHER
NV2t018870003.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t018870003.1	molecular_function	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019]	PANTHER
NV2t018872001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018872001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t018872001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018872001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018872001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t018872001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t018873001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	OMA
NV2t018873001.1	biological_process	GO:0070897	transcription preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]	OMA
NV2t018873001.1	cellular_component	GO:0000120	RNA polymerase I transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I." [GOC:mah]	OMA
NV2t018873001.1	cellular_component	GO:0070860	RNA polymerase I core factor complex	"A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872]	PANTHER
NV2t018873001.1	molecular_function	GO:0001046	core promoter sequence-specific DNA binding	"Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH]	OMA
NV2t018873001.1	molecular_function	GO:0001163	RNA polymerase I transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH]	OMA
NV2t018873002.1	cellular_component	GO:0070860	RNA polymerase I core factor complex	"A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872]	PANTHER
NV2t018873003.1	cellular_component	GO:0070860	RNA polymerase I core factor complex	"A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872]	PANTHER
NV2t018873004.1	cellular_component	GO:0070860	RNA polymerase I core factor complex	"A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872]	PANTHER
NV2t018874001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t018874001.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	PANTHER
NV2t018875001.1	biological_process	GO:0000380	alternative mRNA splicing, via spliceosome	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]	OMA
NV2t018875001.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	OMA
NV2t018875001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t018875001.1	biological_process	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	OMA
NV2t018875001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018875001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t018875001.1	cellular_component	GO:0030532	small nuclear ribonucleoprotein complex	"A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t018875001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t018875001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018875001.1	molecular_function	GO:0030628	pre-mRNA 3'-splice site binding	"Binding to a pre-mRNA 3' splice site sequence." [GOC:jl]	InterPro
NV2t018875001.1	molecular_function	GO:0036002	pre-mRNA binding	"Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]	OMA
NV2t018875001.1	molecular_function	GO:0140098	catalytic activity, acting on RNA	"Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t018876001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018876002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018877001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018877001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t018877002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018877002.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t018878001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018878001.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	InterPro
NV2t018878001.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	OMA
NV2t018878001.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	PANTHER
NV2t018878001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018878001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018879001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018880001.1	molecular_function	GO:0030628	pre-mRNA 3'-splice site binding	"Binding to a pre-mRNA 3' splice site sequence." [GOC:jl]	InterPro
NV2t018881001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018881001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t018881002.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t018881002.1	biological_process	GO:0007029	endoplasmic reticulum organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018881002.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t018881002.1	biological_process	GO:0050766	positive regulation of phagocytosis	"Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]	OMA
NV2t018881002.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t018881002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t018881002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t018881002.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t018881002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t018881002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018881002.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t018881002.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t018881002.1	molecular_function	GO:0005537	mannose binding	"Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [GOC:jl, ISBN:0192800981]	OMA
NV2t018881002.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	OMA
NV2t018882001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018882001.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	InterPro
NV2t018882001.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	PANTHER
NV2t018882002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018882002.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	InterPro
NV2t018882002.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	PANTHER
NV2t018882003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018882003.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	InterPro
NV2t018882003.1	cellular_component	GO:0016602	CCAAT-binding factor complex	"A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851]	PANTHER
NV2t018884001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t018884001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t018884001.1	cellular_component	GO:0005686	U2 snRNP	"A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t018884001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018884001.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t018884001.1	cellular_component	GO:0034719	SMN-Sm protein complex	"A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408]	OMA
NV2t018884001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t018884001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t018884001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018884001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018885001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t018885001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t018885001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t018885001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t018887001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	InterPro
NV2t018887001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	OMA
NV2t018887001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t018887001.1	biological_process	GO:0060623	regulation of chromosome condensation	"Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb]	OMA
NV2t018887001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t018887001.1	cellular_component	GO:0000796	condensin complex	"A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis." [GOC:elh, PMID:17268547, PMID:21795393]	OMA
NV2t018887001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018887001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t018887001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t018887002.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	InterPro
NV2t018887002.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t018887003.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	InterPro
NV2t018887003.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t018887004.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	InterPro
NV2t018887004.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t018887005.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	InterPro
NV2t018887005.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t018888001.1	biological_process	GO:1903358	regulation of Golgi organization	"Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]	OMA
NV2t018888001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t018888001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t018888001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t018888002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t018889001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t018889001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t018889001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t018889001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t018889001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t018889001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t018889001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t018889001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t018889001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	OMA
NV2t018889001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t018889001.1	cellular_component	GO:0070069	cytochrome complex	"A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah]	OMA
NV2t018889001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t018889001.1	molecular_function	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai]	InterPro
NV2t018889001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t018890001.1	biological_process	GO:1990481	mRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]	PANTHER
NV2t018890001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t018890002.1	biological_process	GO:0016556	mRNA modification	"The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t018890002.1	biological_process	GO:0031119	tRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]	InterPro
NV2t018890002.1	biological_process	GO:0031119	tRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]	OMA
NV2t018890002.1	biological_process	GO:1990481	mRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]	PANTHER
NV2t018890002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018890002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018890002.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t018890002.1	molecular_function	GO:0016866	intramolecular transferase activity	"Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t018890003.1	biological_process	GO:0031119	tRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]	InterPro
NV2t018890003.1	biological_process	GO:1990481	mRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]	PANTHER
NV2t018890003.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t018891001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t018891001.1	molecular_function	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	"Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]	OMA
NV2t018891001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018891002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018891003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018895001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018895001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t018895001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t018895002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018895002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t018895003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018895003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t018895004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018895004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t018899001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018899001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018900001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018900002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018900002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018900002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018901001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018901002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t018902001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t018902001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018902001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t018902001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t018904001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t018904001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t018904001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t018904001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018904001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t018910001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018910001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t018912001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018912001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t018914001.1	biological_process	GO:0006693	prostaglandin metabolic process	"The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732]	OMA
NV2t018914001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t018914001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t018914001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t018914001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t018914001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t018914001.1	molecular_function	GO:0036132	13-prostaglandin reductase activity	"Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG_REACTION:R04556, KEGG_REACTION:R04557, PMID:17449869]	PANTHER
NV2t018915001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018915001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018915001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018915001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t018916001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t018916001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t018916001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t018916001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t018919001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018919002.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018919003.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t018920001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018920002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018920002.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t018922001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	OMA
NV2t018922001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	PANTHER
NV2t018922001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t018924001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t018924001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018924001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018924001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018924001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t018924001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t018924001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t018927001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t018927001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018927001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018928001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t018928001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t018928001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t018928001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t018928001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t018930001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t018932001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t018932001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018934001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018934002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018939001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t018939001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t018939001.1	biological_process	GO:0048814	regulation of dendrite morphogenesis	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]	PANTHER
NV2t018939001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t018940001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018940001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t018940001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t018940001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t018940001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t018940001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018940001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018940002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018940002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t018940003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018940003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t018941001.1	cellular_component	GO:1990023	mitotic spindle midzone	"The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]	PANTHER
NV2t018941002.1	biological_process	GO:0001578	microtubule bundle formation	"A process that results in a parallel arrangement of microtubules." [GOC:dph]	OMA
NV2t018941002.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t018941002.1	biological_process	GO:0051256	mitotic spindle midzone assembly	"The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120]	OMA
NV2t018941002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018941002.1	cellular_component	GO:1990023	mitotic spindle midzone	"The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t018941002.1	cellular_component	GO:1990023	mitotic spindle midzone	"The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]	PANTHER
NV2t018941002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t018942001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t018942001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t018942001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t018942001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t018942001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t018942001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t018942001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t018942001.1	molecular_function	GO:0030515	snoRNA binding	"Binding to a small nucleolar RNA." [GOC:mah]	OMA
NV2t018943001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t018943001.1	biological_process	GO:0016050	vesicle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]	OMA
NV2t018943001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t018943001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t018943001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	OMA
NV2t018943001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t018943002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t018943002.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t018943003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t018943003.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t018944001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t018944001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t018944001.1	biological_process	GO:0009435	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	InterPro
NV2t018944001.1	biological_process	GO:0009435	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	PANTHER
NV2t018944001.1	biological_process	GO:0019359	nicotinamide nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]	OMA
NV2t018944001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t018944001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018944001.1	molecular_function	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	"Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1]	OMA
NV2t018944001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t018944002.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t018944002.1	biological_process	GO:0009435	NAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]	PANTHER
NV2t018944002.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t018945001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018945001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t018945002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018945002.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t018945003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018945003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t018945003.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t018945003.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t018945003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018945004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018945004.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t018948001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t018950001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t018950001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t018950001.1	biological_process	GO:0009436	glyoxylate catabolic process	"The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732]	OMA
NV2t018950001.1	biological_process	GO:0042219	cellular modified amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t018950001.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t018950001.1	biological_process	GO:0046700	obsolete heterocycle catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]	OMA
NV2t018950001.1	biological_process	GO:0072330	monocarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t018950001.1	biological_process	GO:1901361	organic cyclic compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t018950001.1	biological_process	GO:1901606	alpha-amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t018950001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t018950001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t018950001.1	molecular_function	GO:0016832	aldehyde-lyase activity	"Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators]	OMA
NV2t018950001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t018951001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t018951001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t018951001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t018951001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t018951001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t018951001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t018951001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t018951001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t018951001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t018951002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t018952001.1	biological_process	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	InterPro
NV2t018952001.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t018952001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t018955001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t018955001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t018955001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t018962001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018962001.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t018962001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018962001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t018962001.1	biological_process	GO:1901658	glycosyl compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t018962001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t018962001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t018962002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018962002.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t018962002.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018962003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018962003.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t018962003.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018962004.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018962004.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t018962004.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018962005.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018962005.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t018962005.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018962006.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018962006.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t018962006.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018962007.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t018962007.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t018962007.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t018964001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t018964001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t018964001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t018964001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018964001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t018970001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t018970001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018970002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t018970002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018970003.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t018970003.1	biological_process	GO:0048172	regulation of short-term neuronal synaptic plasticity	"A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290]	OMA
NV2t018970003.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t018970003.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t018970003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t018970003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018970003.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t018970003.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t018970003.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t018970003.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t018970003.1	cellular_component	GO:0043679	axon terminus	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]	OMA
NV2t018970003.1	molecular_function	GO:0005452	solute:inorganic anion antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)." [GOC:mah]	OMA
NV2t018970003.1	molecular_function	GO:0008510	sodium:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1]	OMA
NV2t018970003.1	molecular_function	GO:0015108	chloride transmembrane transporter activity	"Enables the transfer of chloride ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t018970004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t018970004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018971001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018971001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018971002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t018971002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t018972001.1	biological_process	GO:0006882	intracellular zinc ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t018972001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018972001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t018972001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t018972001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t018972002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t018972002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t018983001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t018988001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t018989001.1	biological_process	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	PANTHER
NV2t018989002.1	biological_process	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	PANTHER
NV2t018991001.1	biological_process	GO:0006549	isoleucine metabolic process	"The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	OMA
NV2t018991001.1	biological_process	GO:0006551	L-leucine metabolic process	"The chemical reactions and pathways involving L-leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]	OMA
NV2t018991001.1	biological_process	GO:0006573	valine metabolic process	"The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai]	OMA
NV2t018991001.1	biological_process	GO:0009081	branched-chain amino acid metabolic process	"The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	InterPro
NV2t018991001.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	OMA
NV2t018991001.1	biological_process	GO:0009099	valine biosynthetic process	"The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]	PANTHER
NV2t018991001.1	biological_process	GO:1901607	alpha-amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie]	OMA
NV2t018991001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t018991001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018991001.1	molecular_function	GO:0052654	L-leucine transaminase activity	"Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN]	OMA
NV2t018991001.1	molecular_function	GO:0052655	L-valine transaminase activity	"Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN]	OMA
NV2t018991001.1	molecular_function	GO:0052656	L-isoleucine transaminase activity	"Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN]	OMA
NV2t018991002.1	biological_process	GO:0009081	branched-chain amino acid metabolic process	"The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	InterPro
NV2t018991002.1	biological_process	GO:0009099	valine biosynthetic process	"The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]	PANTHER
NV2t018991002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t018992001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	OMA
NV2t018992001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t018992001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t018992001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t018992001.1	molecular_function	GO:0061654	NEDD8 conjugating enzyme activity	"Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue." [GOC:dph]	OMA
NV2t019006001.1	biological_process	GO:0030199	collagen fibril organization	"Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194]	OMA
NV2t019006001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t019008001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019008002.1	cellular_component	GO:0031519	PcG protein complex	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]	PANTHER
NV2t019010001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t019010001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t019010002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t019010002.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t019010002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t019010002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t019010002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019010002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t019010003.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t019010003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t019013001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t019013001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	InterPro
NV2t019013001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	OMA
NV2t019015001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t019015001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t019015001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t019015001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t019015001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019015001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019015001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019015001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t019015001.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	InterPro
NV2t019015001.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	OMA
NV2t019015002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019016001.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	InterPro
NV2t019016001.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	OMA
NV2t019016001.1	biological_process	GO:0005978	glycogen biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	PANTHER
NV2t019016001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019016001.1	molecular_function	GO:0004373	glycogen (starch) synthase activity	"Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11]	OMA
NV2t019016001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t019016001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t019017001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t019017001.1	biological_process	GO:0006625	protein targeting to peroxisome	"The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]	OMA
NV2t019017001.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	InterPro
NV2t019017001.1	biological_process	GO:0015919	peroxisomal membrane transport	"The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai]	OMA
NV2t019017001.1	biological_process	GO:0045046	protein import into peroxisome membrane	"The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502]	PANTHER
NV2t019017001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t019017001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t019017002.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	InterPro
NV2t019017002.1	biological_process	GO:0045046	protein import into peroxisome membrane	"The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502]	PANTHER
NV2t019019001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019019001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019029001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t019029002.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t019029002.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	OMA
NV2t019029002.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t019029002.1	biological_process	GO:0006403	RNA localization	"A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t019029002.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t019029002.1	biological_process	GO:0031061	obsolete negative regulation of histone methylation	"OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]	OMA
NV2t019029002.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t019029002.1	biological_process	GO:0035066	obsolete positive regulation of histone acetylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]	OMA
NV2t019029002.1	biological_process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t019029002.1	biological_process	GO:0051569	obsolete regulation of histone H3-K4 methylation	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:ai]	OMA
NV2t019029002.1	biological_process	GO:0070897	transcription preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]	OMA
NV2t019029002.1	biological_process	GO:0071168	protein localization to chromatin	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]	OMA
NV2t019029002.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t019029002.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t019029002.1	biological_process	GO:1901838	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie]	OMA
NV2t019029002.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t019029002.1	biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t019029002.1	biological_process	GO:2001267	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	"Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t019029002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t019029002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019029002.1	cellular_component	GO:0097255	R2TP complex	"A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213]	OMA
NV2t019029002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t019029002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t019029002.1	molecular_function	GO:0001046	core promoter sequence-specific DNA binding	"Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH]	OMA
NV2t019029002.1	molecular_function	GO:0001163	RNA polymerase I transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH]	OMA
NV2t019029002.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t019029002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t019029002.1	molecular_function	GO:0051219	phosphoprotein binding	"Binding to a phosphorylated protein." [GOC:ai]	OMA
NV2t019035001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019036001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019036001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019036001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	PANTHER
NV2t019036001.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	OMA
NV2t019036001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019036001.1	molecular_function	GO:0016805	dipeptidase activity	"Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]	OMA
NV2t019036001.1	molecular_function	GO:0070573	metallodipeptidase activity	"Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019038001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019038001.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t019038001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019038001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019038001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	InterPro
NV2t019038002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019038002.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t019038002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019038002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019038002.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	InterPro
NV2t019038003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019038003.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t019038003.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019038003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019038003.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	InterPro
NV2t019039001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t019039001.1	biological_process	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	"Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]	OMA
NV2t019039001.1	biological_process	GO:0046785	microtubule polymerization	"The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators]	OMA
NV2t019039001.1	biological_process	GO:0051298	centrosome duplication	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]	OMA
NV2t019039001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t019039001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t019039001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t019039001.1	cellular_component	GO:0035371	microtubule plus-end	"The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273]	OMA
NV2t019039001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	InterPro
NV2t019039001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t019039001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	OMA
NV2t019039001.1	molecular_function	GO:0061863	microtubule plus end polymerase	"Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers." [PMID:27872152]	InterPro
NV2t019039001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t019039002.1	molecular_function	GO:0061863	microtubule plus end polymerase	"Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers." [PMID:27872152]	InterPro
NV2t019039003.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	InterPro
NV2t019039003.1	molecular_function	GO:0061863	microtubule plus end polymerase	"Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers." [PMID:27872152]	InterPro
NV2t019041001.1	biological_process	GO:0006007	glucose catabolic process	"The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]	InterPro
NV2t019041001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t019041001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t019041001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t019041001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t019041001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019041001.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t019041001.1	molecular_function	GO:0030145	manganese ion binding	"Binding to a manganese ion (Mn)." [GOC:ai]	InterPro
NV2t019041001.1	molecular_function	GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	"Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.12]	PANTHER
NV2t019041001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019041001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t019041002.1	biological_process	GO:0006007	glucose catabolic process	"The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]	InterPro
NV2t019041002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t019041002.1	molecular_function	GO:0030145	manganese ion binding	"Binding to a manganese ion (Mn)." [GOC:ai]	InterPro
NV2t019041002.1	molecular_function	GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	"Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.12]	PANTHER
NV2t019041002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019041003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t019041003.1	molecular_function	GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	"Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.12]	PANTHER
NV2t019041003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019042001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t019042002.1	biological_process	GO:2001135	regulation of endocytic recycling	"Any process that modulates the frequency, rate or extent of endocytic recycling." [GOC:obol]	PANTHER
NV2t019042002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t019042002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t019042003.1	biological_process	GO:2001135	regulation of endocytic recycling	"Any process that modulates the frequency, rate or extent of endocytic recycling." [GOC:obol]	PANTHER
NV2t019042003.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t019044001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t019045001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019045001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t019045002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019045002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t019046001.1	biological_process	GO:0006875	obsolete intracellular metal ion homeostasis	"OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of metal ions within a cell." [GOC:ai, GOC:mah]	PANTHER
NV2t019046001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019046001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	InterPro
NV2t019046002.1	biological_process	GO:0006875	obsolete intracellular metal ion homeostasis	"OBSOLETE. A homeostatic process involved in the maintenance of a steady state level of metal ions within a cell." [GOC:ai, GOC:mah]	PANTHER
NV2t019046002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019046002.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	InterPro
NV2t019046003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019047001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t019047001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t019048001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t019049001.1	biological_process	GO:0008154	actin polymerization or depolymerization	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t019049001.1	biological_process	GO:0051014	actin filament severing	"The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]	OMA
NV2t019049001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	OMA
NV2t019049001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t019049001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019049001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t019049001.1	molecular_function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	"Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t019049001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t019050001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t019050001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t019051001.1	biological_process	GO:0018209	peptidyl-serine modification	"The modification of peptidyl-serine." [GOC:go_curators]	PANTHER
NV2t019051002.1	biological_process	GO:0018209	peptidyl-serine modification	"The modification of peptidyl-serine." [GOC:go_curators]	PANTHER
NV2t019052001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t019052001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t019053001.1	biological_process	GO:0010977	negative regulation of neuron projection development	"Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t019053001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t019053001.1	biological_process	GO:0031111	negative regulation of microtubule polymerization or depolymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]	OMA
NV2t019053001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t019053001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t019053001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t019053001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019053001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t019053001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t019053001.1	cellular_component	GO:0044295	axonal growth cone	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]	OMA
NV2t019053001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t019053001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t019053001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019053001.1	molecular_function	GO:0005528	FK506 binding	"Binding to a 23-membered macrolide lactone FK506." [GOC:jl]	OMA
NV2t019053001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	OMA
NV2t019053002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t019053002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019058001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019058001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t019060001.1	biological_process	GO:0007010	cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t019060001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t019061001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	PANTHER
NV2t019061001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019062001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	PANTHER
NV2t019062001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019067001.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t019067001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019067002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019068001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t019069001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t019072001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t019072001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t019074001.1	biological_process	GO:0051016	barbed-end actin filament capping	"The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]	PANTHER
NV2t019074001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t019074001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t019076001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t019076001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019076001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t019076001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019076001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t019076001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t019077001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019077001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019078001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t019078001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019080001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t019080001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019080001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019080002.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t019080002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019080002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019082001.1	biological_process	GO:0006780	uroporphyrinogen III biosynthetic process	"The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai]	InterPro
NV2t019082001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t019082001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t019082001.1	biological_process	GO:0033014	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	InterPro
NV2t019082001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t019082001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t019082001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t019082001.1	biological_process	GO:0046394	carboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t019082001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t019082001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t019082001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t019083001.1	biological_process	GO:0006657	CDP-choline pathway	"The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450]	OMA
NV2t019083001.1	biological_process	GO:0006657	CDP-choline pathway	"The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450]	PANTHER
NV2t019083001.1	biological_process	GO:0046337	phosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732]	OMA
NV2t019083001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019083001.1	molecular_function	GO:0004305	ethanolamine kinase activity	"Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine." [EC:2.7.1.82, RHEA:13069]	OMA
NV2t019083002.1	biological_process	GO:0006657	CDP-choline pathway	"The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450]	PANTHER
NV2t019085001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t019085001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t019085001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t019085001.1	molecular_function	GO:0016776	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	OMA
NV2t019086001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t019088001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019090001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	OMA
NV2t019090001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t019090001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019090001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019091001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019091001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t019091001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t019091001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019091001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t019091001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019096001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019096001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t019096001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t019096001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019096001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019096001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t019096001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019096001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019096002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019096002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019096002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019096002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019096003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019096003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019096003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019096003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019096004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019096004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019096004.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019096004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019096005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019096005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019096005.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019096005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019096006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019096006.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019096006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019098001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019098001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019098001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019100001.1	biological_process	GO:0050848	regulation of calcium-mediated signaling	"Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai]	OMA
NV2t019100001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t019100001.1	molecular_function	GO:0022834	ligand-gated channel activity	"Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019100002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t019100003.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t019101001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t019103001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	PANTHER
NV2t019103001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019107001.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	OMA
NV2t019107001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t019107001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t019107001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t019107001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t019107001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t019107001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t019107001.1	cellular_component	GO:0097014	ciliary plasm	"All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]	PANTHER
NV2t019107001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019107001.1	molecular_function	GO:0045503	dynein light chain binding	"Binding to a light chain of the dynein complex." [GOC:bf]	OMA
NV2t019107001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	OMA
NV2t019110001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019110001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t019110001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019110001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019110001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019110002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019110002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t019110002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019110002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019110002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019110003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019110003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t019110003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019110003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019110003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019113001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019114001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019114002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019123001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019123001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019126001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t019126001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	PANTHER
NV2t019127001.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	PANTHER
NV2t019127001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019127001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019127002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t019127002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019127002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019127003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t019127003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019127003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019127003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019127004.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	PANTHER
NV2t019127004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019127004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019127005.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	PANTHER
NV2t019127005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019127005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019127006.1	biological_process	GO:0006376	mRNA splice site recognition	"Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]	PANTHER
NV2t019127006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019127006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019129001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019129004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019129005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019130001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t019130001.1	molecular_function	GO:0140603	obsolete ATP hydrolysis activity	"OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [GOC:curators]	PANTHER
NV2t019132001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t019132001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t019132001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t019132001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t019132001.1	molecular_function	GO:0140097	catalytic activity, acting on DNA	"Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t019146001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019146001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t019146001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t019146001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t019146001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019146001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t019146001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t019146001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t019146001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019146001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019146001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019146002.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t019146002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t019146002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019146002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019148001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019149001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t019149001.1	biological_process	GO:0015937	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	InterPro
NV2t019149001.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	OMA
NV2t019149001.1	biological_process	GO:0034030	ribonucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t019149001.1	biological_process	GO:0034033	purine nucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t019149001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019149001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019149001.1	molecular_function	GO:0004594	pantothenate kinase activity	"Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]	OMA
NV2t019149001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019149001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t019149001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t019149001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t019149001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t019150001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019150001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t019151001.1	cellular_component	GO:0033588	elongator holoenzyme complex	"A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]	InterPro
NV2t019151001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019153001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019153001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019161001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019161001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019161001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t019161001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t019161001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019161001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t019162001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t019162001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019162001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t019162001.1	cellular_component	GO:0000811	GINS complex	"A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]	OMA
NV2t019162001.1	cellular_component	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	OMA
NV2t019162001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t019162002.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019162003.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019162004.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019163001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019163001.1	molecular_function	GO:2001069	glycogen binding	"Binding to glycogen." [GOC:mengo_curators]	PANTHER
NV2t019165001.1	biological_process	GO:0018057	peptidyl-lysine oxidation	"The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121]	PANTHER
NV2t019165001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019165001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019165001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t019165001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t019165001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	InterPro
NV2t019165001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t019165002.1	biological_process	GO:0018057	peptidyl-lysine oxidation	"The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121]	PANTHER
NV2t019165002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019165002.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	InterPro
NV2t019165003.1	biological_process	GO:0018057	peptidyl-lysine oxidation	"The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121]	PANTHER
NV2t019165003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019165003.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	InterPro
NV2t019166001.1	biological_process	GO:0018057	peptidyl-lysine oxidation	"The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121]	PANTHER
NV2t019166001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019166001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019166001.1	molecular_function	GO:0004720	protein-lysine 6-oxidase activity	"Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide." [EC:1.4.3.13]	OMA
NV2t019166001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t019166001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t019166001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	InterPro
NV2t019168001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019168001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019168001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t019171001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t019171001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t019171001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019173002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019174001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t019174001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019174001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t019174001.1	biological_process	GO:1902412	regulation of mitotic cytokinesis	"Any process that modulates the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie]	InterPro
NV2t019174001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t019190001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t019190001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019192001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t019192001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t019192001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	OMA
NV2t019192001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019194003.1	molecular_function	GO:0030368	interleukin-17 receptor activity	"Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]	PANTHER
NV2t019194004.1	molecular_function	GO:0030368	interleukin-17 receptor activity	"Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]	PANTHER
NV2t019194006.1	molecular_function	GO:0030368	interleukin-17 receptor activity	"Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]	PANTHER
NV2t019194007.1	molecular_function	GO:0030368	interleukin-17 receptor activity	"Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]	PANTHER
NV2t019195001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	InterPro
NV2t019195001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t019198001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t019198001.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	InterPro
NV2t019198001.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	OMA
NV2t019198002.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	InterPro
NV2t019198003.1	biological_process	GO:0090522	vesicle tethering involved in exocytosis	"The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008]	InterPro
NV2t019199001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t019199001.1	biological_process	GO:0033108	mitochondrial respiratory chain complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]	OMA
NV2t019199001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t019199001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t019199001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t019199001.1	molecular_function	GO:0016531	copper chaperone activity	"Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376]	InterPro
NV2t019199001.1	molecular_function	GO:0016531	copper chaperone activity	"Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376]	OMA
NV2t019199002.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t019199002.1	molecular_function	GO:0016531	copper chaperone activity	"Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376]	InterPro
NV2t019200001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019200001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019200002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019200002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019200003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019200003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019206001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t019206001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t019206001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019206001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t019206002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t019206002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019207002.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	InterPro
NV2t019207002.1	molecular_function	GO:1990825	sequence-specific mRNA binding	"Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]	PANTHER
NV2t019207003.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	InterPro
NV2t019207003.1	molecular_function	GO:1990825	sequence-specific mRNA binding	"Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]	PANTHER
NV2t019207004.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	InterPro
NV2t019207004.1	molecular_function	GO:1990825	sequence-specific mRNA binding	"Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]	PANTHER
NV2t019207005.1	biological_process	GO:0006415	translational termination	"The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]	InterPro
NV2t019207005.1	molecular_function	GO:1990825	sequence-specific mRNA binding	"Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]	PANTHER
NV2t019209001.1	molecular_function	GO:0003796	lysozyme activity	"Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan." [EC:3.2.1.17, PMID:22748813]	InterPro
NV2t019209001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019211001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019211001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t019211002.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t019211002.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t019211002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019211002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019211002.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t019211003.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t019211003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019212001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t019212001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019212001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019224001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019224001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019224001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019224001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t019224001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t019226001.1	biological_process	GO:0002090	regulation of receptor internalization	"Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]	OMA
NV2t019226001.1	biological_process	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t019226001.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	OMA
NV2t019226001.1	biological_process	GO:0048261	negative regulation of receptor-mediated endocytosis	"Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators]	OMA
NV2t019226001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t019226001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019226001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t019227001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t019227002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t019228001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019228001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t019241001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019241001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t019245001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t019245001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019245001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t019245001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019245001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t019252001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019252001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019252001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019255001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t019255001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t019255001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t019255001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t019257001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t019257001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019258001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019258001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019259001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019259002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019259002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019259002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019259003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019259003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019259003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019259003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019259004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019259004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019259004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019260001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019260001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019260001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019260002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019260002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019260002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019260002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019260003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019260003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019260003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019266001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t019266001.1	biological_process	GO:0001837	epithelial to mesenchymal transition	"A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]	OMA
NV2t019266001.1	biological_process	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	OMA
NV2t019266001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t019266001.1	biological_process	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	OMA
NV2t019266001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t019266001.1	biological_process	GO:0043508	negative regulation of JUN kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl]	OMA
NV2t019266001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019266001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019266001.1	biological_process	GO:0050729	positive regulation of inflammatory response	"Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]	OMA
NV2t019266001.1	biological_process	GO:0051148	negative regulation of muscle cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]	OMA
NV2t019266001.1	biological_process	GO:0055006	cardiac cell development	"The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol]	OMA
NV2t019266001.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	OMA
NV2t019266001.1	biological_process	GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction	"Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade." [GOC:TermGenie]	OMA
NV2t019266001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019266001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019266002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019266003.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019266004.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019266005.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019266006.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019271001.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	PANTHER
NV2t019271002.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	PANTHER
NV2t019272002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019272003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019272004.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019273001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t019273001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t019273001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t019273001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019273001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t019273001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t019275001.1	biological_process	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	PANTHER
NV2t019275001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019275001.1	molecular_function	GO:0042799	histone H4K20 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein." [PMID:12086618]	InterPro
NV2t019275002.1	biological_process	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	PANTHER
NV2t019275002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019275002.1	molecular_function	GO:0042799	histone H4K20 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein." [PMID:12086618]	InterPro
NV2t019275003.1	biological_process	GO:0045814	negative regulation of gene expression, epigenetic	"An epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation." [PMID:22243696]	PANTHER
NV2t019286001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019286001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019286001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019302001.1	biological_process	GO:0000055	ribosomal large subunit export from nucleus	"The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t019302001.1	biological_process	GO:0000056	ribosomal small subunit export from nucleus	"The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]	OMA
NV2t019302001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	InterPro
NV2t019302001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	OMA
NV2t019302001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t019302001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019302001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t019302001.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	InterPro
NV2t019302001.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t019302001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t019302001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t019302002.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	InterPro
NV2t019302002.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	InterPro
NV2t019302002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t019302003.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	InterPro
NV2t019302003.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	InterPro
NV2t019303001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019304001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019304001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019304001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t019304001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t019304002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019304003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019304004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019304005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019304005.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t019304006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019304006.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t019305001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019305001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t019305002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019305002.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t019305003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019305003.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	InterPro
NV2t019309002.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t019309002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t019309002.1	molecular_function	GO:1905502	acetyl-CoA binding	"Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component." [GO_REF:0000067, GOC:bc, GOC:krc, GOC:PARL, GOC:TermGenie, PMID:24927529]	PANTHER
NV2t019310001.1	biological_process	GO:2001020	obsolete regulation of response to DNA damage stimulus	"OBSOLETE. Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]	OMA
NV2t019310001.1	biological_process	GO:2001020	obsolete regulation of response to DNA damage stimulus	"OBSOLETE. Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]	PANTHER
NV2t019310001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t019310001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t019310001.1	molecular_function	GO:0051998	protein carboxyl O-methyltransferase activity	"Catalysis of the transfer of a methyl group to a carboxyl group on a protein." [GOC:ai]	OMA
NV2t019310002.1	biological_process	GO:2001020	obsolete regulation of response to DNA damage stimulus	"OBSOLETE. Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol]	PANTHER
NV2t019311001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t019311001.1	biological_process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t019311001.1	biological_process	GO:0055070	copper ion homeostasis	"Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]	OMA
NV2t019311001.1	biological_process	GO:1902305	regulation of sodium ion transmembrane transport	"Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664]	OMA
NV2t019311001.1	biological_process	GO:1903828	negative regulation of protein localization	"Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t019311001.1	biological_process	GO:1904063	negative regulation of cation transmembrane transport	"Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482]	OMA
NV2t019311001.1	biological_process	GO:2000008	regulation of protein localization to cell surface	"Any process that modulates the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]	OMA
NV2t019311001.1	biological_process	GO:2000009	negative regulation of protein localization to cell surface	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]	PANTHER
NV2t019311001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t019312001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019312002.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t019312002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019312002.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t019312002.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t019312002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t019312002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t019312002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t019312003.1	molecular_function	GO:0008681	2-octaprenyl-6-methoxyphenol hydroxylase activity	"Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O." [PMID:27822549, PMID:4572721, RHEA:29407]	InterPro
NV2t019312003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019312003.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t019312003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t019312003.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t019312004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019312004.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t019312004.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t019312004.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t019313001.1	molecular_function	GO:0042392	sphingosine-1-phosphate phosphatase activity	"Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:8663293]	PANTHER
NV2t019315001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019315001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t019315001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t019316001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019316002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019316002.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t019316002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t019316002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t019316002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t019316002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019316002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019316002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019316003.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t019316003.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t019316003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019316003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019316004.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019317001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t019317001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019317001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019317001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019317001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019317003.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t019317003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019317003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019317003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019317004.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t019317004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019317004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019317004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019317005.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t019317005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019317005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019317005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019317006.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t019317006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019317006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019317006.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019317007.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t019317007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019317007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019317007.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019318002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t019318002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t019318002.1	biological_process	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t019318002.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t019318002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019318002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019318002.1	cellular_component	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t019318002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t019318002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019318002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t019318002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t019319001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019319001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t019319002.1	biological_process	GO:0035592	establishment of protein localization to extracellular region	"The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF]	PANTHER
NV2t019319002.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	InterPro
NV2t019319002.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t019319002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t019319003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019319003.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t019319004.1	biological_process	GO:0035592	establishment of protein localization to extracellular region	"The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF]	PANTHER
NV2t019319004.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t019319005.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019319005.1	molecular_function	GO:0004857	enzyme inhibitor activity	"Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc]	InterPro
NV2t019319005.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t019319005.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t019320001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019320001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019320001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019320001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019320002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019320002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019320003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019320003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019321001.1	biological_process	GO:0006744	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	PANTHER
NV2t019321001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t019321001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t019321002.1	biological_process	GO:0006744	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	PANTHER
NV2t019321003.1	biological_process	GO:0006744	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	PANTHER
NV2t019322001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019322002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019323001.1	biological_process	GO:0010923	negative regulation of phosphatase activity	"Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t019323001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	InterPro
NV2t019323001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	OMA
NV2t019331001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019331001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019339001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019339001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340005.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340006.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340007.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340007.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340008.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340008.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340009.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340009.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340010.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340010.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340011.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340011.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340012.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340012.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340013.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019340013.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019343001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019343001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t019345001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t019345001.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t019346001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019346001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019346001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t019350001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t019350001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t019350001.1	biological_process	GO:0090502	obsolete RNA phosphodiester bond hydrolysis, endonucleolytic	"OBSOLETE. The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb]	OMA
NV2t019350001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t019350001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	InterPro
NV2t019350001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t019350001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t019350001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t019351001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019351001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019363001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t019363001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019364001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t019364001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019366001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t019366001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019366001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t019367001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t019367001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019367001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019368001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t019368001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019368001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019368001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019368002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t019368002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019369001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	OMA
NV2t019369001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	PANTHER
NV2t019369001.1	biological_process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	"Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah]	OMA
NV2t019369001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t019372001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t019372001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019372001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t019372001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019372001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019372001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t019372001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019372001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019372002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019377001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019377001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019377001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t019377001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019388001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t019388001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t019388001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019388001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	OMA
NV2t019388002.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t019388003.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t019389001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t019389001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019390001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019391001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019391001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019391001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t019391002.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019391003.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019392001.1	cellular_component	GO:0097228	sperm principal piece	"The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836]	InterPro
NV2t019392002.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t019392002.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t019392002.1	cellular_component	GO:0097228	sperm principal piece	"The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836]	InterPro
NV2t019393001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t019393001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019394001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019397001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t019397001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t019397001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t019402002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019402002.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	InterPro
NV2t019402004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019402004.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	InterPro
NV2t019403001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019403001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	InterPro
NV2t019404001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019404001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	InterPro
NV2t019405001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019405001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019405001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019406001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t019406001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019406002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t019406002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019406003.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t019406003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019407001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t019407001.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	PANTHER
NV2t019407001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t019407001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019407002.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	PANTHER
NV2t019407002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019408001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t019408001.1	molecular_function	GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah]	PANTHER
NV2t019408002.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t019408002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t019408002.1	molecular_function	GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah]	PANTHER
NV2t019408003.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t019408003.1	biological_process	GO:1902775	mitochondrial large ribosomal subunit assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit." [GO_REF:0000079, GOC:TermGenie, PMID:24206665]	OMA
NV2t019408003.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t019408003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t019408003.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t019408003.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	OMA
NV2t019408003.1	molecular_function	GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah]	PANTHER
NV2t019408003.1	molecular_function	GO:0062105	RNA 2'-O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide." [PMID:30626973, RHEA:58956]	OMA
NV2t019408004.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t019408004.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t019408004.1	molecular_function	GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah]	PANTHER
NV2t019409001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t019409001.1	biological_process	GO:0045740	positive regulation of DNA replication	"Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators]	PANTHER
NV2t019409001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019411001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	InterPro
NV2t019411001.1	molecular_function	GO:0140223	general transcription initiation factor activity	"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]	PANTHER
NV2t019411002.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	InterPro
NV2t019411002.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t019411002.1	biological_process	GO:0006384	transcription initiation at RNA polymerase III promoter	"A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III." [GOC:mah, GOC:txnOH]	OMA
NV2t019411002.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t019411002.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t019411002.1	molecular_function	GO:0001016	RNA polymerase III transcription regulatory region sequence-specific DNA binding	"Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:12381659]	OMA
NV2t019411002.1	molecular_function	GO:0001046	core promoter sequence-specific DNA binding	"Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH]	OMA
NV2t019411002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t019411002.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t019411002.1	molecular_function	GO:0140223	general transcription initiation factor activity	"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]	PANTHER
NV2t019411003.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	InterPro
NV2t019411003.1	molecular_function	GO:0140223	general transcription initiation factor activity	"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]	PANTHER
NV2t019413001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019413001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t019413001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t019413001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t019413001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t019413001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019413001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019414001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019415001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019415001.1	biological_process	GO:0001711	endodermal cell fate commitment	"The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437]	OMA
NV2t019415001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t019415001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t019415001.1	biological_process	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t019415001.1	biological_process	GO:0019827	stem cell population maintenance	"The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437]	OMA
NV2t019415001.1	biological_process	GO:0031325	positive regulation of cellular metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t019415001.1	biological_process	GO:0051173	obsolete positive regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t019415001.1	cellular_component	GO:0016593	Cdc73/Paf1 complex	"A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]	OMA
NV2t019415001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t019415001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019415001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t019415001.1	molecular_function	GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	"Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944]	OMA
NV2t019415001.1	molecular_function	GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	"Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944]	PANTHER
NV2t019415002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019415002.1	molecular_function	GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	"Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944]	PANTHER
NV2t019415003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019416001.1	biological_process	GO:0140042	lipid droplet formation	"A process that results in the assembly, arrangement of constituent parts of a lipid droplet." [PMID:28011631]	PANTHER
NV2t019416002.1	biological_process	GO:0140042	lipid droplet formation	"A process that results in the assembly, arrangement of constituent parts of a lipid droplet." [PMID:28011631]	PANTHER
NV2t019416002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019423001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t019423002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t019424001.1	biological_process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]	OMA
NV2t019424001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t019424001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019424001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019424001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t019424001.1	biological_process	GO:0032780	negative regulation of ATP-dependent activity	"Any process that stops or reduces the rate of an ATP-dependent activity." [GOC:mah]	OMA
NV2t019424001.1	biological_process	GO:0043086	negative regulation of catalytic activity	"Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t019424001.1	biological_process	GO:0045787	positive regulation of cell cycle	"Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]	OMA
NV2t019424001.1	biological_process	GO:0071902	positive regulation of protein serine/threonine kinase activity	"Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah]	OMA
NV2t019424001.1	biological_process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t019424001.1	biological_process	GO:2001251	negative regulation of chromosome organization	"Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t019424001.1	cellular_component	GO:0000439	transcription factor TFIIH core complex	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]	OMA
NV2t019424001.1	cellular_component	GO:0005675	transcription factor TFIIH holo complex	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]	OMA
NV2t019424001.1	cellular_component	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	"Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc]	OMA
NV2t019424001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t019424001.1	molecular_function	GO:0047485	obsolete protein N-terminus binding	"OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t019424001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	InterPro
NV2t019424001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	OMA
NV2t019424002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019425001.1	biological_process	GO:0006306	obsolete DNA methylation	"OBSOLETE. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732]	OMA
NV2t019425001.1	biological_process	GO:0007141	male meiosis I	"A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]	OMA
NV2t019425001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t019425001.1	biological_process	GO:0009566	fertilization	"The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732]	OMA
NV2t019425001.1	biological_process	GO:0010529	obsolete negative regulation of transposition	"OBSOLETE. Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]	OMA
NV2t019425001.1	biological_process	GO:0010529	obsolete negative regulation of transposition	"OBSOLETE. Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]	PANTHER
NV2t019425001.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	OMA
NV2t019425001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019425001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t019425001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019425001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t019425001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019425001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019425001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t019426001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019426001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t019426001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019426001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019426002.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t019427001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t019427001.1	cellular_component	GO:0043292	contractile muscle fiber	"Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194]	OMA
NV2t019427001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t019427001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t019427001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t019427001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t019427001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t019428001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	PANTHER
NV2t019429001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	PANTHER
NV2t019432001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t019432001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t019432001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t019433001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019433001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t019433001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t019433001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	OMA
NV2t019433001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	PANTHER
NV2t019435001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t019436001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t019436001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t019437001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t019437001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t019442001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t019443001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t019443002.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t019443003.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t019444001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	PANTHER
NV2t019444001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t019445001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t019445001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019455001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t019455001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t019455001.1	biological_process	GO:0050727	regulation of inflammatory response	"Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]	OMA
NV2t019455001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t019455001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019455001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t019455001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t019455001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t019456001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t019458001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t019458001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t019467001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	OMA
NV2t019467001.1	biological_process	GO:1902653	secondary alcohol biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t019467001.1	cellular_component	GO:0005637	nuclear inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]	OMA
NV2t019467001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t019467001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t019467001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t019467001.1	molecular_function	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t019467001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t019467001.1	molecular_function	GO:0050613	delta14-sterol reductase activity	"Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70]	PANTHER
NV2t019468001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019469001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t019469001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019469001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019469001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t019469002.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t019469002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019470001.1	biological_process	GO:0000245	spliceosomal complex assembly	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]	OMA
NV2t019470001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t019470001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019470001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	OMA
NV2t019470001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	PANTHER
NV2t019473001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019473001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t019473001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019473001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t019473001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019473001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019473001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019473002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019473002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019473002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019473002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019474001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019475001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	InterPro
NV2t019475001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019475002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019475003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019476001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t019476001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t019476001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t019476001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	PANTHER
NV2t019476001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t019476001.1	biological_process	GO:0016071	mRNA metabolic process	"The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	OMA
NV2t019476001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t019476001.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	OMA
NV2t019476001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019476001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t019476001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019476001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019478001.1	biological_process	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	OMA
NV2t019478001.1	biological_process	GO:0043043	peptide biosynthetic process	"The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl]	OMA
NV2t019478001.1	biological_process	GO:0044550	secondary metabolite biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]	OMA
NV2t019478001.1	biological_process	GO:0046938	phytochelatin biosynthetic process	"The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732]	InterPro
NV2t019478001.1	biological_process	GO:0098849	cellular detoxification of cadmium ion	"Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw]	PANTHER
NV2t019478001.1	molecular_function	GO:0016755	aminoacyltransferase activity	"Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t019478001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t019480001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019480002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019480003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019480004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480004.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019480005.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480005.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019480007.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480007.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019480008.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480008.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480008.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019480009.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480009.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480009.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019480010.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019480010.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019480010.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019481001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019481001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t019482001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019482001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t019482001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019482001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019482001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019482001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t019482002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019482002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019482002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t019483001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019483001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019483001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t019483001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t019485001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019486001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019486002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019486002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t019486002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019489001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019491001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019492001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t019492001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t019492001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019492001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019494001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019494001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019496001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019497001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019497002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019497002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019498001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t019498001.1	biological_process	GO:0010592	positive regulation of lamellipodium assembly	"Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]	OMA
NV2t019498001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	OMA
NV2t019498001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019498001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t019498001.1	biological_process	GO:0050807	regulation of synapse organization	"Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t019498001.1	biological_process	GO:0051640	organelle localization	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]	OMA
NV2t019498001.1	biological_process	GO:0051962	positive regulation of nervous system development	"Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	OMA
NV2t019498001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t019498001.1	biological_process	GO:1903046	meiotic cell cycle process	"A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]	OMA
NV2t019498001.1	biological_process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	"Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299]	OMA
NV2t019498001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019498001.1	cellular_component	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	OMA
NV2t019498001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t019498001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t019498001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t019498001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019498001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t019498001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t019498002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t019501001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t019501001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t019502001.1	biological_process	GO:0000338	protein deneddylation	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]	OMA
NV2t019502001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t019502001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t019502001.1	biological_process	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]	OMA
NV2t019502001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t019502001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	OMA
NV2t019502001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t019502001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t019503001.1	biological_process	GO:0006020	inositol metabolic process	"The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684]	OMA
NV2t019503001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t019503001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t019503001.1	biological_process	GO:0034637	obsolete cellular carbohydrate biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah]	OMA
NV2t019503001.1	biological_process	GO:0046173	polyol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators]	OMA
NV2t019503001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019503001.1	molecular_function	GO:0004512	inositol-3-phosphate synthase activity	"Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10716]	OMA
NV2t019503002.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t019503003.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t019503004.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t019503005.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t019504001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019504001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019504001.1	biological_process	GO:0007586	digestion	"The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]	OMA
NV2t019504001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019504001.1	molecular_function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	OMA
NV2t019504001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019504001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019504002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019504002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t019504002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019504003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019504003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t019504004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019504004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t019504004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019506001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019506001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	InterPro
NV2t019506001.1	molecular_function	GO:0042781	3'-tRNA processing endoribonuclease activity	"Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [PMID:12032089, PMID:21208191]	OMA
NV2t019506001.1	molecular_function	GO:0042781	3'-tRNA processing endoribonuclease activity	"Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [PMID:12032089, PMID:21208191]	PANTHER
NV2t019507001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t019507001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t019507001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t019507001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t019507001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t019507001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t019507001.1	molecular_function	GO:0070180	large ribosomal subunit rRNA binding	"Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]	OMA
NV2t019507001.1	molecular_function	GO:0070180	large ribosomal subunit rRNA binding	"Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]	PANTHER
NV2t019513001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019513001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t019514001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t019514001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019514002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t019514002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019515001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t019515001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	InterPro
NV2t019515001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t019516001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t019516001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019516001.1	molecular_function	GO:0070568	guanylyltransferase activity	"Catalysis of the transfer of a guanylyl group to an acceptor." [GOC:mah]	OMA
NV2t019517001.1	biological_process	GO:0030162	regulation of proteolysis	"Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]	OMA
NV2t019517001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t019517001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t019517001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019517001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019517001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t019518001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t019519001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t019519001.1	biological_process	GO:0046474	glycerophospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	PANTHER
NV2t019519001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019519001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	InterPro
NV2t019519001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t019521001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	PANTHER
NV2t019521001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019521001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019521001.1	molecular_function	GO:0016423	tRNA (guanine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [GOC:go-curators]	OMA
NV2t019522001.1	biological_process	GO:0045595	regulation of cell differentiation	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]	PANTHER
NV2t019522001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t019523001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t019523001.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t019523002.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t019523002.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t019523002.1	biological_process	GO:0019985	translesion synthesis	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]	OMA
NV2t019523002.1	biological_process	GO:0042276	error-prone translesion synthesis	"The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]	PANTHER
NV2t019523002.1	cellular_component	GO:0008622	epsilon DNA polymerase complex	"A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]	InterPro
NV2t019523002.1	cellular_component	GO:0008622	epsilon DNA polymerase complex	"A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]	OMA
NV2t019523002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t019524001.1	biological_process	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	"The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783]	OMA
NV2t019524001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	OMA
NV2t019524001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t019524001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t019524001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t019524001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t019525001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t019525001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t019525001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t019525001.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t019525001.1	biological_process	GO:0032488	Cdc42 protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478]	PANTHER
NV2t019525001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t019525001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019525001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t019525002.1	biological_process	GO:0032488	Cdc42 protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Cdc42 subfamily relays a signal." [GOC:mah, PMID:18558478]	PANTHER
NV2t019525002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019526001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019526001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t019526001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t019527001.1	biological_process	GO:0006559	L-phenylalanine catabolic process	"The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]	OMA
NV2t019527001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t019527001.1	biological_process	GO:0009072	aromatic amino acid metabolic process	"The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]	InterPro
NV2t019527001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t019527001.1	molecular_function	GO:0004364	glutathione transferase activity	"Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]	OMA
NV2t019527001.1	molecular_function	GO:0016034	maleylacetoacetate isomerase activity	"Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2]	PANTHER
NV2t019527001.1	molecular_function	GO:0016859	cis-trans isomerase activity	"Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732]	OMA
NV2t019527001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t019531001.1	biological_process	GO:0045017	glycerolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	InterPro
NV2t019531002.1	biological_process	GO:0045017	glycerolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	InterPro
NV2t019532001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t019532001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t019532001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t019532001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019532001.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	OMA
NV2t019532001.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	PANTHER
NV2t019532002.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	PANTHER
NV2t019532003.1	cellular_component	GO:0030119	AP-type membrane coat adaptor complex	"Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]	PANTHER
NV2t019533001.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t019533001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019533002.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t019533002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019533004.1	biological_process	GO:0055074	calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t019533004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019536001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019536001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019536001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t019538001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019539001.1	biological_process	GO:2000272	negative regulation of signaling receptor activity	"Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol]	OMA
NV2t019539001.1	biological_process	GO:2000272	negative regulation of signaling receptor activity	"Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol]	PANTHER
NV2t019539001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019539001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019539001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t019539001.1	molecular_function	GO:0008022	obsolete protein C-terminus binding	"OBSOLETE. Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t019540001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019541001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019541001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t019542001.1	biological_process	GO:0045747	positive regulation of Notch signaling pathway	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t019542001.1	biological_process	GO:0045747	positive regulation of Notch signaling pathway	"Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	PANTHER
NV2t019542001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019544001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t019544001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t019545001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t019545001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t019546001.1	biological_process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	"Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr]	OMA
NV2t019546001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t019546001.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	OMA
NV2t019546001.1	cellular_component	GO:0005675	transcription factor TFIIH holo complex	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]	OMA
NV2t019546001.1	cellular_component	GO:0070985	transcription factor TFIIK complex	"A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993]	InterPro
NV2t019546001.1	cellular_component	GO:0070985	transcription factor TFIIK complex	"A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993]	PANTHER
NV2t019546001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	OMA
NV2t019547001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019547001.1	molecular_function	GO:0071253	connexin binding	"Binding to a connexin, any of a group of related proteins that assemble to form gap junctions." [GOC:mah, PMID:19864490]	InterPro
NV2t019547002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019547002.1	molecular_function	GO:0071253	connexin binding	"Binding to a connexin, any of a group of related proteins that assemble to form gap junctions." [GOC:mah, PMID:19864490]	InterPro
NV2t019548001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t019548001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019548001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019549001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019550001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	PANTHER
NV2t019550001.1	biological_process	GO:0098958	retrograde axonal transport of mitochondrion	"The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse." [GOC:dos]	OMA
NV2t019550001.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	OMA
NV2t019551001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019553001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t019553001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t019553001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t019553001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t019559001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019562001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t019562001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019562001.1	biological_process	GO:0001932	regulation of protein phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]	OMA
NV2t019562001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t019562001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t019562001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t019562001.1	biological_process	GO:0014067	obsolete negative regulation of phosphatidylinositol 3-kinase signaling	"OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef]	OMA
NV2t019562001.1	biological_process	GO:0031333	negative regulation of protein-containing complex assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t019562001.1	biological_process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t019562001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t019562001.1	biological_process	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	OMA
NV2t019562001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t019562001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t019562001.1	biological_process	GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t019562001.1	biological_process	GO:0062207	regulation of pattern recognition receptor signaling pathway	"Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]	OMA
NV2t019562001.1	biological_process	GO:0071456	cellular response to hypoxia	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]	OMA
NV2t019562001.1	biological_process	GO:1901796	regulation of signal transduction by p53 class mediator	"Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie]	OMA
NV2t019562001.1	biological_process	GO:1901837	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	"Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie]	OMA
NV2t019562001.1	biological_process	GO:1903006	positive regulation of protein K63-linked deubiquitination	"Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133]	OMA
NV2t019562001.1	biological_process	GO:1903715	regulation of aerobic respiration	"Any process that modulates the frequency, rate or extent of aerobic respiration." [GO_REF:0000058, GOC:TermGenie, PMID:19266076]	OMA
NV2t019562001.1	cellular_component	GO:0000792	heterochromatin	"A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156]	OMA
NV2t019562001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t019562001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t019562001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019562001.1	molecular_function	GO:0002039	p53 binding	"Binding to one of the p53 family of proteins." [GOC:hjd]	OMA
NV2t019562001.1	molecular_function	GO:0008097	5S rRNA binding	"Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]	OMA
NV2t019562001.1	molecular_function	GO:0008097	5S rRNA binding	"Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t019562001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t019563001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t019563002.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	OMA
NV2t019563002.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t019563002.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t019563002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019563002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019563002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019563003.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t019563003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019563004.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t019563004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019567001.1	biological_process	GO:0000379	tRNA-type intron splice site recognition and cleavage	"RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]	InterPro
NV2t019567001.1	biological_process	GO:0000379	tRNA-type intron splice site recognition and cleavage	"RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]	PANTHER
NV2t019567001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	InterPro
NV2t019567001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	OMA
NV2t019567001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t019567001.1	cellular_component	GO:1902555	endoribonuclease complex	"A protein complex which is capable of endoribonuclease activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t019567001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019567001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019567001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t019567001.1	molecular_function	GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah]	OMA
NV2t019567001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t019569001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019569001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019570001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t019570001.1	biological_process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	"Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]	OMA
NV2t019570001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t019570001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t019570001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t019570001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t019570001.1	molecular_function	GO:0016922	nuclear receptor binding	"Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974]	OMA
NV2t019570001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t019572001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t019572001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019572002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019573001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t019573001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019573001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019573002.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t019573002.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t019573002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019573002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019573002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019573003.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t019573003.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t019573004.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t019573004.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t019573004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019573004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019575001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t019575001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t019575001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t019576001.1	molecular_function	GO:0140110	transcription regulator activity	"A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]	PANTHER
NV2t019578001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t019581001.1	biological_process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	OMA
NV2t019581001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t019581001.1	biological_process	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	"A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544]	OMA
NV2t019581001.1	biological_process	GO:0035019	somatic stem cell population maintenance	"Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]	OMA
NV2t019581001.1	biological_process	GO:0044344	cellular response to fibroblast growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf]	OMA
NV2t019581001.1	biological_process	GO:0048103	somatic stem cell division	"The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089]	OMA
NV2t019581001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t019581001.1	biological_process	GO:0061158	3'-UTR-mediated mRNA destabilization	"An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:dph, GOC:jh]	OMA
NV2t019581001.1	biological_process	GO:0061326	renal tubule development	"The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10]	OMA
NV2t019581001.1	biological_process	GO:0070371	ERK1 and ERK2 cascade	"A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development." [PMID:20811974, PMID:23125017, PMID:28903453]	OMA
NV2t019581001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	OMA
NV2t019581001.1	biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]	OMA
NV2t019581001.1	biological_process	GO:0071383	cellular response to steroid hormone stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah]	OMA
NV2t019581001.1	biological_process	GO:0071560	cellular response to transforming growth factor beta stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]	OMA
NV2t019581001.1	biological_process	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie]	OMA
NV2t019581001.1	biological_process	GO:1901991	negative regulation of mitotic cell cycle phase transition	"Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721]	OMA
NV2t019581001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t019581001.1	biological_process	GO:2000737	negative regulation of stem cell differentiation	"Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol]	OMA
NV2t019581001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019581001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019581001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	InterPro
NV2t019581001.1	molecular_function	GO:0035925	mRNA 3'-UTR AU-rich region binding	"Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]	OMA
NV2t019581001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019581001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t019581002.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	InterPro
NV2t019581002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019584001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019584001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019584001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019589001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t019589001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t019589001.1	cellular_component	GO:0097431	mitotic spindle pole	"Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]	OMA
NV2t019589001.1	cellular_component	GO:0097431	mitotic spindle pole	"Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw]	PANTHER
NV2t019589001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019589001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t019591001.1	biological_process	GO:0009890	negative regulation of biosynthetic process	"Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]	InterPro
NV2t019592001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t019592001.1	biological_process	GO:0032988	protein-RNA complex disassembly	"The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah]	OMA
NV2t019592001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t019592001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t019592001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t019592001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019592001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019592001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019593001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t019593001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t019593001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t019593001.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	OMA
NV2t019593001.1	biological_process	GO:0051156	glucose 6-phosphate metabolic process	"The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]	PANTHER
NV2t019593001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019593001.1	molecular_function	GO:0004346	glucose-6-phosphatase activity	"Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate." [EC:3.1.3.9, RHEA:16689]	InterPro
NV2t019593001.1	molecular_function	GO:0019203	carbohydrate phosphatase activity	"Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah]	OMA
NV2t019595001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t019595001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t019595001.1	biological_process	GO:0032370	positive regulation of lipid transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t019595001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t019595001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t019595001.1	biological_process	GO:0042632	cholesterol homeostasis	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]	OMA
NV2t019595001.1	biological_process	GO:0043933	protein-containing complex organization	"Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah]	OMA
NV2t019595001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t019595001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t019595001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t019595001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t019595001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t019595001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t019595001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019595001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t019595001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t019595001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t019596001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019596001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019596001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019596001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t019596001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t019596001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t019597001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t019597001.1	biological_process	GO:0007292	female gamete generation	"Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732]	OMA
NV2t019597001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t019597001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t019597001.1	biological_process	GO:0048232	male gamete generation	"Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid]	OMA
NV2t019597001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t019597001.1	biological_process	GO:0071168	protein localization to chromatin	"Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]	OMA
NV2t019597001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019597001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	OMA
NV2t019597001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	PANTHER
NV2t019597001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t019597001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t019597001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019597001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t019597001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t019597001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t019597001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t019599001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	OMA
NV2t019599001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019599001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t019599001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t019599001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019599001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t019599001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t019600001.1	cellular_component	GO:0005892	acetylcholine-gated channel complex	"A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]	InterPro
NV2t019600001.1	cellular_component	GO:0005892	acetylcholine-gated channel complex	"A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462]	OMA
NV2t019600001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019602001.1	biological_process	GO:0010634	positive regulation of epithelial cell migration	"Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t019602001.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t019602001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t019602001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	OMA
NV2t019602001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t019602001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t019602001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019602001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019602001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t019603001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t019603001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t019603001.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t019603001.1	cellular_component	GO:0005673	transcription factor TFIIE complex	"A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462]	OMA
NV2t019603001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t019603001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t019604001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	PANTHER
NV2t019606001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	PANTHER
NV2t019606002.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	PANTHER
NV2t019606003.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	PANTHER
NV2t019607001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t019607001.1	biological_process	GO:0032367	intracellular cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah]	InterPro
NV2t019607001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t019607001.1	biological_process	GO:0055092	sterol homeostasis	"Any process involved in the maintenance of an internal steady state of sterol within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t019607001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019607001.1	molecular_function	GO:0015485	cholesterol binding	"Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732]	OMA
NV2t019607001.1	molecular_function	GO:0032934	sterol binding	"Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah]	InterPro
NV2t019607001.1	molecular_function	GO:0120013	lipid transfer activity	"Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t019608001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019608001.1	molecular_function	GO:0051033	RNA transmembrane transporter activity	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t019608002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019608002.1	molecular_function	GO:0051033	RNA transmembrane transporter activity	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t019608003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019608003.1	molecular_function	GO:0051033	RNA transmembrane transporter activity	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t019608004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019608004.1	molecular_function	GO:0051033	RNA transmembrane transporter activity	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t019608005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019608005.1	molecular_function	GO:0051033	RNA transmembrane transporter activity	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t019608006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019608006.1	molecular_function	GO:0051033	RNA transmembrane transporter activity	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t019609001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609001.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609002.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609003.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609003.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609004.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609004.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609005.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609005.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609006.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609006.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609007.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609008.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609008.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609008.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609009.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609009.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609009.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609009.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609010.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609010.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609010.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609010.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609011.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609011.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609011.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609011.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609012.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609012.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609012.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609012.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609013.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609013.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609013.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609013.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609013.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609014.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609014.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609014.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609014.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609014.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609015.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609015.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609015.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609015.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609015.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609016.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609016.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609016.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609016.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609016.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609017.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609017.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609017.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609017.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609017.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609018.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609018.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609018.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609018.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609018.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609019.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609019.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609019.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609019.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609019.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019609020.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019609020.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t019609020.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019609020.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019609020.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	PANTHER
NV2t019618001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019621002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019626001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019626001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019627001.1	biological_process	GO:0006826	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t019627001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t019627001.1	molecular_function	GO:0004322	ferroxidase activity	"Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [RHEA:11148]	OMA
NV2t019627001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t019627001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019627001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019627001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t019627002.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019627002.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019630001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019631001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019631002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019633001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019633001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t019634001.1	cellular_component	GO:0031515	tRNA (m1A) methyltransferase complex	"A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239]	InterPro
NV2t019639001.1	cellular_component	GO:0031515	tRNA (m1A) methyltransferase complex	"A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239]	InterPro
NV2t019639002.1	cellular_component	GO:0031515	tRNA (m1A) methyltransferase complex	"A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239]	InterPro
NV2t019640001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019642001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019642001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t019642001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019642001.1	molecular_function	GO:0004709	MAP kinase kinase kinase activity	"Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]	OMA
NV2t019642001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019642001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019642001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019642002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019642002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019642002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019642002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019642003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019642003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t019642003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019642003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019645001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t019645001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t019645001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t019645001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t019645001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019646001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t019646002.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t019648001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019648002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t019648003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648004.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648005.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648006.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648006.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648007.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648007.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648007.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648008.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648008.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648008.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648009.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648009.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648009.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648010.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648010.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648010.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648011.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648011.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648011.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648012.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648012.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648012.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648013.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648013.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648013.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019648014.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019648014.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019648014.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019650001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019650002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019651001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019651001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019651001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t019652001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019652001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019652001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019652001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t019658001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019658001.1	molecular_function	GO:0051033	RNA transmembrane transporter activity	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t019660001.1	biological_process	GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411]	PANTHER
NV2t019661001.1	biological_process	GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411]	PANTHER
NV2t019665001.1	biological_process	GO:0006687	glycosphingolipid metabolic process	"The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]	OMA
NV2t019665001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t019665001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t019665001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t019665001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	PANTHER
NV2t019665001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t019665001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t019665001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t019665001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t019666001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	PANTHER
NV2t019668001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019668001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t019668001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019668001.1	molecular_function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr]	OMA
NV2t019668001.1	molecular_function	GO:0017069	snRNA binding	"Binding to a small nuclear RNA (snRNA)." [GOC:mah]	InterPro
NV2t019668001.1	molecular_function	GO:0097322	7SK snRNA binding	"Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533]	OMA
NV2t019668001.1	molecular_function	GO:0097322	7SK snRNA binding	"Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533]	PANTHER
NV2t019669001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019669001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t019669001.1	molecular_function	GO:0017095	heparan sulfate 6-O-sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808]	PANTHER
NV2t019670001.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	PANTHER
NV2t019671001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019671001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t019671001.1	cellular_component	GO:0005838	proteasome regulatory particle	"A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t019676001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019676001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t019676002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019677001.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	PANTHER
NV2t019677001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019679001.1	biological_process	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t019679001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t019679001.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	InterPro
NV2t019679001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t019679001.1	biological_process	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437]	InterPro
NV2t019679001.1	biological_process	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437]	OMA
NV2t019679001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t019679001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019679001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019679001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019679001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t019681001.1	biological_process	GO:0006826	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t019681001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t019681001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t019681001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019681001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019681001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t019681002.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019681002.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019682001.1	biological_process	GO:0006826	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t019682001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t019682001.1	biological_process	GO:0051651	maintenance of location in cell	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]	OMA
NV2t019682001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019682001.1	molecular_function	GO:0004322	ferroxidase activity	"Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [RHEA:11148]	OMA
NV2t019682001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t019682001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019682001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019682001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t019684001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t019684001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t019684001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t019684001.1	molecular_function	GO:0035312	5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]	InterPro
NV2t019684001.1	molecular_function	GO:0035312	5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]	PANTHER
NV2t019684001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019684002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t019684002.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t019684002.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t019684002.1	molecular_function	GO:0035312	5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]	InterPro
NV2t019684002.1	molecular_function	GO:0035312	5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]	PANTHER
NV2t019684002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019684003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t019684003.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t019684003.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t019684003.1	molecular_function	GO:0035312	5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]	InterPro
NV2t019684003.1	molecular_function	GO:0035312	5'-3' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]	PANTHER
NV2t019684003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019685001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019685001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019685001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019685001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t019686001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019686001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t019687001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019687001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019687001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t019697001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019701003.1	biological_process	GO:0006826	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t019701003.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t019701003.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t019701003.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t019701003.1	biological_process	GO:0051651	maintenance of location in cell	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]	OMA
NV2t019701003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019701003.1	molecular_function	GO:0004322	ferroxidase activity	"Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [RHEA:11148]	OMA
NV2t019701003.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t019701003.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019701003.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019701003.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t019701004.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019701004.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019701005.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t019701005.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t019704001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019704001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t019704001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t019704001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019704001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t019705001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t019705001.1	biological_process	GO:1902983	DNA strand elongation involved in mitotic DNA replication	"Any DNA strand elongation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]	PANTHER
NV2t019706001.1	biological_process	GO:0030488	tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]	PANTHER
NV2t019709001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019709001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t019709001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t019709001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t019709001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019709001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019710001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t019710001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	OMA
NV2t019710001.1	molecular_function	GO:0101005	deubiquitinase activity	"An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:mec, PMID:30783221]	PANTHER
NV2t019713001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	InterPro
NV2t019713001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019714002.1	biological_process	GO:0071586	CAAX-box protein processing	"The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]	InterPro
NV2t019714003.1	biological_process	GO:0071586	CAAX-box protein processing	"The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]	InterPro
NV2t019717001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t019719001.1	biological_process	GO:0006144	purine nucleobase metabolic process	"The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]	OMA
NV2t019719001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t019719001.1	biological_process	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	OMA
NV2t019719001.1	biological_process	GO:0072523	purine-containing compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t019719001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019719001.1	molecular_function	GO:0004854	xanthine dehydrogenase activity	"Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4]	OMA
NV2t019719001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t019719001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019719001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019719001.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	InterPro
NV2t019719001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019719001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t019719001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t019719001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t019719001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t019719001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t019719001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t019719002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019719002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019719002.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	InterPro
NV2t019719002.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t019719002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t019719003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019719003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019719003.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	InterPro
NV2t019719003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019719003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t019719003.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t019719004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019719004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019719004.1	molecular_function	GO:0043546	molybdopterin cofactor binding	"Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]	InterPro
NV2t019720001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019721001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019725001.1	molecular_function	GO:0004089	carbonate dehydratase activity	"Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O." [EC:4.2.1.1]	OMA
NV2t019725001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019725001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019725002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019727001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019729001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019730001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019731001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019731001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t019733001.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t019733001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	InterPro
NV2t019733001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019733002.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t019733002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019733003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t019733003.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t019733003.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t019733003.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	InterPro
NV2t019733003.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t019733003.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t019733003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019733003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t019733004.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t019733004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019733005.1	biological_process	GO:0090385	phagosome-lysosome fusion	"The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb]	PANTHER
NV2t019733005.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	InterPro
NV2t019733005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019734001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t019734001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t019734001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t019734001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t019734001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t019734001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t019736001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t019736001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t019736001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t019736001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t019740001.1	biological_process	GO:0018216	peptidyl-arginine methylation	"The addition of a methyl group to an arginine residue in a protein." [GOC:mah]	OMA
NV2t019740001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t019740001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t019740001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t019740001.1	molecular_function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069]	OMA
NV2t019740001.1	molecular_function	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	"Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069]	PANTHER
NV2t019742001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t019742001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t019742001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t019742001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t019742001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t019742001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t019742001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t019742001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019742001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019742001.1	molecular_function	GO:0005104	fibroblast growth factor receptor binding	"Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb]	OMA
NV2t019742001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t019742001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t019743001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019743001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t019743001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019743001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019743001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019743002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019743002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t019743002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019743003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019743003.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t019743003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019743004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019743004.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t019743004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019743005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019743005.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t019743005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019743006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019743006.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t019743006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019745001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019745001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t019745001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t019746001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t019746001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t019746001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019746001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019746001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t019749001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019749001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019749001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019749001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t019749001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t019749001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t019750001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t019750001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t019750001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t019750001.1	biological_process	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	OMA
NV2t019750001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t019750001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019750001.1	cellular_component	GO:0030289	protein phosphatase 4 complex	"A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits." [GOC:bhm, PMID:10026142]	OMA
NV2t019750001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t019750001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t019750001.1	molecular_function	GO:0072542	protein phosphatase activator activity	"Binds to and increases the activity of a protein phosphatase." [GOC:mah]	PANTHER
NV2t019750002.1	molecular_function	GO:0072542	protein phosphatase activator activity	"Binds to and increases the activity of a protein phosphatase." [GOC:mah]	PANTHER
NV2t019750003.1	molecular_function	GO:0072542	protein phosphatase activator activity	"Binds to and increases the activity of a protein phosphatase." [GOC:mah]	PANTHER
NV2t019750004.1	molecular_function	GO:0072542	protein phosphatase activator activity	"Binds to and increases the activity of a protein phosphatase." [GOC:mah]	PANTHER
NV2t019751001.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	PANTHER
NV2t019751002.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t019751002.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	OMA
NV2t019751002.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	PANTHER
NV2t019753001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t019753001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019753001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019754001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t019754001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	PANTHER
NV2t019754001.1	biological_process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t019754001.1	biological_process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t019754001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019755001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t019755001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t019755001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019755002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t019755002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019758001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019759001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019759001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019759002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019760001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019760001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019760001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019761001.1	biological_process	GO:0019693	ribose phosphate metabolic process	"The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	PANTHER
NV2t019761002.1	biological_process	GO:0019693	ribose phosphate metabolic process	"The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	PANTHER
NV2t019761002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019762001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t019762001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019762001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t019762002.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t019762002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019762003.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t019762003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019762004.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t019762004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019762005.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t019762005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019762006.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t019762006.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019764001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t019764001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t019764001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t019764001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019764001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t019765001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019765001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t019765001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t019765001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019765002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019765002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t019765002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t019766001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t019766001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t019766002.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t019766002.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t019766002.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t019766002.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t019768001.1	biological_process	GO:0031998	regulation of fatty acid beta-oxidation	"Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah]	PANTHER
NV2t019769001.1	biological_process	GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	"The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]	OMA
NV2t019769001.1	biological_process	GO:0070901	mitochondrial tRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]	PANTHER
NV2t019769001.1	biological_process	GO:0090646	mitochondrial tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw]	OMA
NV2t019769001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t019769001.1	molecular_function	GO:0016423	tRNA (guanine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [GOC:go-curators]	OMA
NV2t019769001.1	molecular_function	GO:0052906	tRNA (guanine(37)-N1)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.228]	InterPro
NV2t019772001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	InterPro
NV2t019772001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t019772001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t019772001.1	cellular_component	GO:0044614	nuclear pore cytoplasmic filaments	"Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t019774001.1	biological_process	GO:0032527	protein exit from endoplasmic reticulum	"The directed movement of proteins from the endoplasmic reticulum." [GOC:rb]	PANTHER
NV2t019774001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019774002.1	biological_process	GO:0032527	protein exit from endoplasmic reticulum	"The directed movement of proteins from the endoplasmic reticulum." [GOC:rb]	PANTHER
NV2t019774002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019776001.1	cellular_component	GO:0031519	PcG protein complex	"A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]	PANTHER
NV2t019778001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t019778001.1	molecular_function	GO:0008453	alanine-glyoxylate transaminase activity	"Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44]	OMA
NV2t019778001.1	molecular_function	GO:0047304	2-aminoethylphosphonate-pyruvate transaminase activity	"Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, RHEA:17021]	InterPro
NV2t019779001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t019779002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t019780001.1	cellular_component	GO:0036128	CatSper complex	"A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039]	InterPro
NV2t019780001.1	cellular_component	GO:0097228	sperm principal piece	"The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836]	PANTHER
NV2t019781001.1	molecular_function	GO:0052751	GDP-mannose hydrolase activity	"Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate." [PMID:16766526]	PANTHER
NV2t019782001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t019782001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t019782002.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t019782002.1	biological_process	GO:0044458	motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf]	OMA
NV2t019782002.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t019782002.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t019782002.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t019782002.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t019782002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t019782002.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	OMA
NV2t019783001.1	biological_process	GO:0005980	glycogen catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732]	OMA
NV2t019783001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019783001.1	molecular_function	GO:0008184	glycogen phosphorylase activity	"Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]	InterPro
NV2t019783001.1	molecular_function	GO:0008184	glycogen phosphorylase activity	"Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]	OMA
NV2t019783001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019783001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t019783001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t019783002.1	molecular_function	GO:0008184	glycogen phosphorylase activity	"Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]	InterPro
NV2t019783002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019783002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t019783003.1	molecular_function	GO:0008184	glycogen phosphorylase activity	"Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]	InterPro
NV2t019783003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019783003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t019783004.1	molecular_function	GO:0008184	glycogen phosphorylase activity	"Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]	InterPro
NV2t019783004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019783004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t019784001.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	PANTHER
NV2t019785001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t019785001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	PANTHER
NV2t019786001.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	OMA
NV2t019786001.1	biological_process	GO:0009446	putrescine biosynthetic process	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t019786001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t019786001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t019786001.1	molecular_function	GO:0047632	agmatine deiminase activity	"Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]	PANTHER
NV2t019787001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019787001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t019790001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019790001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019790001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019790002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019790002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019790003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019790003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019792001.1	biological_process	GO:0008608	attachment of spindle microtubules to kinetochore	"The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137]	OMA
NV2t019792001.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	InterPro
NV2t019792001.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	OMA
NV2t019794002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t019798001.1	biological_process	GO:0034755	iron ion transmembrane transport	"A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah, PMID:11390404]	OMA
NV2t019798001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019798001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t019801001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t019803001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t019803002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t019805001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t019805004.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t019805006.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t019810001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t019810002.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t019810002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019810002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t019810002.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t019816001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019816001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019816002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019816002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019816003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019816003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t019816003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t019817001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	InterPro
NV2t019817001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t019817001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019817001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019817001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019817002.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	InterPro
NV2t019817002.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t019817002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019817002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019817002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019817003.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	InterPro
NV2t019817003.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t019817003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019817003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019817003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019820001.1	biological_process	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t019820001.1	biological_process	GO:0050708	regulation of protein secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	OMA
NV2t019820001.1	biological_process	GO:0050708	regulation of protein secretion	"Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	PANTHER
NV2t019820001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t019820001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019820001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t019821001.1	biological_process	GO:0000902	cell morphogenesis	"The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t019821001.1	biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t019821001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t019821001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t019821001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	OMA
NV2t019821001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t019821001.1	biological_process	GO:0048666	neuron development	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]	OMA
NV2t019821001.1	biological_process	GO:0051716	cellular response to stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl]	OMA
NV2t019821001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019821001.1	cellular_component	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	OMA
NV2t019821001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t019821001.1	cellular_component	GO:0045177	apical part of cell	"The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]	OMA
NV2t019821001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019821001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019821002.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t019821002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019821003.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t019821003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019822002.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019823001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t019823001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t019823001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t019823001.1	biological_process	GO:0035459	vesicle cargo loading	"The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle." [GOC:bf, GOC:lb]	OMA
NV2t019823001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t019823001.1	biological_process	GO:0090110	COPII-coated vesicle cargo loading	"The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb]	PANTHER
NV2t019823001.1	biological_process	GO:0090114	COPII-coated vesicle budding	"The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t019823001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t019823001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019823001.1	cellular_component	GO:0019898	extrinsic component of membrane	"The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]	OMA
NV2t019823001.1	cellular_component	GO:0030120	vesicle coat	"A membrane coat found on a coated vesicle." [GOC:mah]	OMA
NV2t019823001.1	cellular_component	GO:0030127	COPII vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]	InterPro
NV2t019823001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t019823001.1	cellular_component	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	OMA
NV2t019823001.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	OMA
NV2t019823001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t019823001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t019823001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019825001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019825001.1	biological_process	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	OMA
NV2t019825001.1	biological_process	GO:0050684	regulation of mRNA processing	"Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]	PANTHER
NV2t019825001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019825001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019825001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019825001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019825001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t019828001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019828002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t019830001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019830002.1	biological_process	GO:0019953	sexual reproduction	"A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid)." [Wikipedia:Sexual_reproduction]	OMA
NV2t019830002.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t019830002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019830002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019831001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t019831001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t019831001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t019831001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019831001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t019831002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019831003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t019835001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	OMA
NV2t019835001.1	biological_process	GO:0006085	acetyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]	PANTHER
NV2t019835001.1	biological_process	GO:0019427	acetyl-CoA biosynthetic process from acetate	"The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY]	InterPro
NV2t019835001.1	biological_process	GO:0032787	monocarboxylic acid metabolic process	"The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]	OMA
NV2t019835001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t019835001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t019835001.1	molecular_function	GO:0016878	acid-thiol ligase activity	"Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1.-, GOC:mah]	OMA
NV2t019835001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t019835001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t019835001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t019836001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019836001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019836001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	PANTHER
NV2t019836001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019836002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019836002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t019836002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019836002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019836003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019836003.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t019836003.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t019836003.1	biological_process	GO:0019221	cytokine-mediated signaling pathway	"The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629]	OMA
NV2t019836003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t019836003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t019836003.1	biological_process	GO:0043687	post-translational protein modification	"The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]	OMA
NV2t019836003.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019836003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019836003.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	OMA
NV2t019836003.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t019836003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019836003.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t019836003.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t019836003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019836003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019836003.1	molecular_function	GO:0035175	histone H3S10 kinase activity	"Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3." [GOC:bf, PMID:15041176]	OMA
NV2t019837001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019837001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t019837001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t019837001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t019842001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t019842001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019842001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019842001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019845001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t019845001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019845001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019846001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t019846001.1	biological_process	GO:0010557	positive regulation of macromolecule biosynthetic process	"Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t019846001.1	biological_process	GO:0015833	peptide transport	"The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t019846001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t019846001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t019846001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t019846001.1	biological_process	GO:0031328	positive regulation of cellular biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t019846001.1	biological_process	GO:0034514	mitochondrial unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004]	OMA
NV2t019846001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t019846001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t019846001.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t019846001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t019846001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t019846001.1	biological_process	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t019846001.1	biological_process	GO:0090374	oligopeptide export from mitochondrion	"The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115]	PANTHER
NV2t019846001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t019846001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t019846001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t019846001.1	biological_process	GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	"OBSOLETE. Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]	OMA
NV2t019846001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t019846001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019846001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019846001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t019846001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t019846001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t019846001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t019846001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t019846001.1	molecular_function	GO:1904680	peptide transmembrane transporter activity	"Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw]	OMA
NV2t019847001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019847001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t019847001.1	biological_process	GO:0003002	regionalization	"The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]	OMA
NV2t019847001.1	biological_process	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	OMA
NV2t019847001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t019847001.1	biological_process	GO:0009799	specification of symmetry	"The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators]	OMA
NV2t019847001.1	biological_process	GO:0010453	regulation of cell fate commitment	"Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]	OMA
NV2t019847001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t019847001.1	biological_process	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	OMA
NV2t019847001.1	biological_process	GO:0030513	positive regulation of BMP signaling pathway	"Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]	OMA
NV2t019847001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t019847001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t019847001.1	biological_process	GO:0048333	mesodermal cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh]	OMA
NV2t019847001.1	biological_process	GO:0048736	appendage development	"The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc]	OMA
NV2t019847001.1	biological_process	GO:0060393	obsolete regulation of pathway-restricted SMAD protein phosphorylation	"OBSOLETE. Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t019847001.1	biological_process	GO:0060395	SMAD protein signal transduction	"An intracellular signaling cassette that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus and regulates transcription of specific target genes." [GOC:BHF]	OMA
NV2t019847001.1	biological_process	GO:0060485	mesenchyme development	"The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph]	OMA
NV2t019847001.1	biological_process	GO:0060562	epithelial tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph]	OMA
NV2t019847001.1	biological_process	GO:0061311	cell surface receptor signaling pathway involved in heart development	"The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling]	OMA
NV2t019847001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t019847001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t019847001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019847001.1	molecular_function	GO:0005125	cytokine activity	"The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802]	OMA
NV2t019847001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t019847001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t019847001.1	molecular_function	GO:0070700	BMP receptor binding	"Binding to a BMP receptor." [GOC:BHF, GOC:vk]	OMA
NV2t019847002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019847002.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	InterPro
NV2t019850001.1	biological_process	GO:0008344	adult locomotory behavior	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]	OMA
NV2t019850001.1	biological_process	GO:0048512	circadian behavior	"The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr]	OMA
NV2t019850001.1	biological_process	GO:0050804	modulation of chemical synaptic transmission	"Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]	OMA
NV2t019850001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019850001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019850001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019851001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t019851001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019851001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	PANTHER
NV2t019852001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019853001.1	biological_process	GO:0000291	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]	OMA
NV2t019853001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t019853001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t019853001.1	biological_process	GO:0045948	positive regulation of translational initiation	"Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t019853001.1	biological_process	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]	OMA
NV2t019853001.1	biological_process	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]	PANTHER
NV2t019853001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t019853001.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	OMA
NV2t019853001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019853001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t019853001.1	molecular_function	GO:0003727	single-stranded RNA binding	"Binding to single-stranded RNA." [GOC:jl]	OMA
NV2t019853001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t019853002.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t019853002.1	biological_process	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	"Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]	PANTHER
NV2t019853002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019854001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t019854001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019854002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	OMA
NV2t019854002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t019854002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019854002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019855001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019855001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019857001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019857001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019858001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019860001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019861001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019861001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	InterPro
NV2t019861001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019861001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019862001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019862001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t019863001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019863001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019863002.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019863002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019864001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019864001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019866001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019866001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	InterPro
NV2t019866001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t019866001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019866001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t019866001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019866001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019868001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t019868001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t019872001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t019872001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t019872001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t019872001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019872001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t019872001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t019874001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019874001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019875001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	InterPro
NV2t019875001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t019875001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019875001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t019876001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t019876001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t019876001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t019876001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019876001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019876001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t019876001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t019876001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019876001.1	cellular_component	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	OMA
NV2t019876001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t019876001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t019876001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019876001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019876001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t019876001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t019876001.1	molecular_function	GO:0097157	pre-mRNA intronic binding	"Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624]	OMA
NV2t019876002.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019876002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019876003.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019876003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019876004.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019876004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019876005.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019876005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019876005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019876006.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019876006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019876007.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019876007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019876007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019876008.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019876008.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019876008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019877001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t019877001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	PANTHER
NV2t019877001.1	molecular_function	GO:0000062	fatty-acyl-CoA binding	"Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]	InterPro
NV2t019877001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t019877001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t019877001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t019877001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t019877001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t019878001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019878001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019879001.1	molecular_function	GO:0051864	histone H3K36 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16362057]	PANTHER
NV2t019880001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t019880001.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t019880002.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t019880002.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t019881001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t019881001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t019881001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t019881002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t019881002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t019889001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	InterPro
NV2t019889001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t019889001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	PANTHER
NV2t019889001.1	biological_process	GO:0051028	mRNA transport	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t019889001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t019889001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t019889001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019889001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t019889001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019889001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t019889001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019889001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t019891001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t019891001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019891001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019891001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t019891001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t019891001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t019891001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t019891001.1	molecular_function	GO:0022824	transmitter-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019891001.1	molecular_function	GO:0099095	ligand-gated monoatomic anion channel activity	"Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019891001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t019893001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t019893001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t019894001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019894001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019894001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019894002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019894002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019895001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019895001.1	molecular_function	GO:0032036	myosin heavy chain binding	"Binding to a heavy chain of a myosin complex." [GOC:mah]	PANTHER
NV2t019896001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t019896001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019896002.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t019896002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019896003.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t019896003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019896003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t019896003.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t019898001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t019898001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t019898001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	OMA
NV2t019898001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	OMA
NV2t019898001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t019898001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t019898001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t019898001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t019898001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019898001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019900001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	PANTHER
NV2t019900001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019902001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019902002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t019903001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t019903001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t019904001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019904001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t019905001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019906001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019906002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019909001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019909001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019909001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019909001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t019909001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019911001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t019911001.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t019911001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019911001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019911001.1	molecular_function	GO:0017147	Wnt-protein binding	"Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]	OMA
NV2t019911001.1	molecular_function	GO:0042813	Wnt receptor activity	"Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]	OMA
NV2t019912001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019912001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019912002.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019912002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019912003.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019912004.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t019913001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019913001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t019913001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t019913001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019914001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	OMA
NV2t019914001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t019914001.1	biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	OMA
NV2t019914001.1	biological_process	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah]	OMA
NV2t019914001.1	biological_process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t019914001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t019914001.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	InterPro
NV2t019914001.1	cellular_component	GO:0030014	CCR4-NOT complex	"The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114]	OMA
NV2t019914001.1	cellular_component	GO:0030015	CCR4-NOT core complex	"The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136]	PANTHER
NV2t019914001.1	molecular_function	GO:0005154	epidermal growth factor receptor binding	"Binding to an epidermal growth factor receptor." [GOC:ai]	OMA
NV2t019914001.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	OMA
NV2t019914001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t019914001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t019914001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t019915001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t019915001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t019916001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t019916001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t019916001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t019916001.1	biological_process	GO:0032091	negative regulation of protein binding	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t019916001.1	biological_process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t019916001.1	biological_process	GO:0070372	regulation of ERK1 and ERK2 cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]	OMA
NV2t019916001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t019916001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019916001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t019916001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t019916001.1	molecular_function	GO:1990444	F-box domain binding	"Binding to an F-box domain of a protein." [GOC:bf, GOC:PARL, InterPro:IPR001810, PMID:12628165]	PANTHER
NV2t019918001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019919001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019919002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019920001.1	biological_process	GO:0032504	obsolete multicellular organism reproduction	"OBSOLETE. The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid]	OMA
NV2t019920001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t019921001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t019922001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t019922001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t019922001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t019922001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019922001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019922001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t019922001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t019922001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t019922001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t019922002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t019922002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019922002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t019922003.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t019922003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019922003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t019923001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t019923001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t019923001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t019923001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019923001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019923001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t019923001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t019924001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t019924001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019924001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t019927001.1	biological_process	GO:0008592	regulation of Toll signaling pathway	"Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]	OMA
NV2t019927001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t019927001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019927001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t019927001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t019927001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t019927002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019927002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t019928001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t019928001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019928001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019928001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019937001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019937001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t019937001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t019937001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t019937001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019940001.1	biological_process	GO:0001654	eye development	"The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]	OMA
NV2t019940001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t019940001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t019940001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t019940001.1	biological_process	GO:0002702	positive regulation of production of molecular mediator of immune response	"Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]	OMA
NV2t019940001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t019940001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t019940001.1	biological_process	GO:0007162	negative regulation of cell adhesion	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]	OMA
NV2t019940001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	InterPro
NV2t019940001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t019940001.1	biological_process	GO:0007413	axonal fasciculation	"The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]	OMA
NV2t019940001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t019940001.1	biological_process	GO:0007612	learning	"Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544]	OMA
NV2t019940001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t019940001.1	biological_process	GO:0021952	central nervous system projection neuron axonogenesis	"Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t019940001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t019940001.1	biological_process	GO:0032101	regulation of response to external stimulus	"Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]	OMA
NV2t019940001.1	biological_process	GO:0032413	negative regulation of ion transmembrane transporter activity	"Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb]	OMA
NV2t019940001.1	biological_process	GO:0032414	positive regulation of ion transmembrane transporter activity	"Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb]	OMA
NV2t019940001.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t019940001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t019940001.1	biological_process	GO:0046580	negative regulation of Ras protein signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	OMA
NV2t019940001.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t019940001.1	biological_process	GO:0048168	regulation of neuronal synaptic plasticity	"A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, PMID:11891290]	OMA
NV2t019940001.1	biological_process	GO:0048562	embryonic organ morphogenesis	"Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t019940001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t019940001.1	biological_process	GO:0050806	positive regulation of synaptic transmission	"Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]	OMA
NV2t019940001.1	biological_process	GO:0050878	regulation of body fluid levels	"Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t019940001.1	biological_process	GO:0051965	positive regulation of synapse assembly	"Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr]	OMA
NV2t019940001.1	biological_process	GO:0060997	dendritic spine morphogenesis	"The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]	OMA
NV2t019940001.1	biological_process	GO:0061041	regulation of wound healing	"Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph]	OMA
NV2t019940001.1	biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]	OMA
NV2t019940001.1	biological_process	GO:0072359	circulatory system development	"The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009]	OMA
NV2t019940001.1	biological_process	GO:0090596	sensory organ morphogenesis	"Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]	OMA
NV2t019940001.1	biological_process	GO:0099601	regulation of neurotransmitter receptor activity	"Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos]	OMA
NV2t019940001.1	biological_process	GO:2000272	negative regulation of signaling receptor activity	"Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol]	OMA
NV2t019940001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t019940001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t019940001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t019940001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t019940001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t019940001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t019940001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	OMA
NV2t019940001.1	molecular_function	GO:0001540	amyloid-beta binding	"Binding to an amyloid-beta peptide/protein." [GOC:hjd]	OMA
NV2t019940001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t019940001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019940001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t019940001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t019940001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019940001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t019942001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t019942001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019942001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019942001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t019942002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t019942002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019942003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t019942003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019943001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t019943001.1	biological_process	GO:0005991	trehalose metabolic process	"The chemical reactions and pathways involving trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose." [GOC:jl, ISBN:0028623819]	InterPro
NV2t019943001.1	biological_process	GO:0005993	trehalose catabolic process	"The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose." [GOC:jl, ISBN:0028623819]	OMA
NV2t019943001.1	biological_process	GO:0005993	trehalose catabolic process	"The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose." [GOC:jl, ISBN:0028623819]	PANTHER
NV2t019943001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t019943001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t019943001.1	molecular_function	GO:0004555	alpha,alpha-trehalase activity	"Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [PMID:19897915, RHEA:32675]	OMA
NV2t019944001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t019944001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	PANTHER
NV2t019947001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t019947001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019947001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t019947001.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t019947001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t019947001.1	molecular_function	GO:0005248	voltage-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019947001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019948001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t019948001.1	biological_process	GO:0019236	response to pheromone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]	InterPro
NV2t019948001.1	biological_process	GO:0019236	response to pheromone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]	OMA
NV2t019950001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t019950001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t019950001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t019950001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019950001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t019950001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t019951001.1	biological_process	GO:0044528	regulation of mitochondrial mRNA stability	"Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs." [GOC:al, GOC:jl]	PANTHER
NV2t019954001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t019954001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t019955001.1	biological_process	GO:0032886	regulation of microtubule-based process	"Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]	OMA
NV2t019957001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t019959001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019959001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019959001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t019959001.1	molecular_function	GO:0004984	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	OMA
NV2t019959001.1	molecular_function	GO:0005549	odorant binding	"Binding to an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]	OMA
NV2t019960001.1	cellular_component	GO:0043592	exosporium	"The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg]	InterPro
NV2t019962001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	PANTHER
NV2t019962001.1	molecular_function	GO:0004298	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	InterPro
NV2t019962001.1	molecular_function	GO:0004298	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t019962001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t019963001.1	biological_process	GO:0001941	postsynaptic membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr]	OMA
NV2t019963001.1	biological_process	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]	InterPro
NV2t019963001.1	biological_process	GO:0007529	establishment of synaptic specificity at neuromuscular junction	"The biological process in which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete]	OMA
NV2t019963001.1	biological_process	GO:0031503	protein-containing complex localization	"A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t019963001.1	biological_process	GO:0032324	molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]	InterPro
NV2t019963001.1	biological_process	GO:0032324	molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]	OMA
NV2t019963001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t019963001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t019963001.1	biological_process	GO:0072578	neurotransmitter-gated ion channel clustering	"The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane." [GOC:dsf, PMID:20843816]	OMA
NV2t019963001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019963001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t019963001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t019963001.1	cellular_component	GO:0099572	postsynaptic specialization	"A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028]	OMA
NV2t019963001.1	molecular_function	GO:0061599	molybdopterin molybdotransferase activity	"Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP." [EC:2.10.1.1, GOC:dph]	PANTHER
NV2t019963001.1	molecular_function	GO:0070566	adenylyltransferase activity	"Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]	OMA
NV2t019965001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t019966001.1	biological_process	GO:0036149	phosphatidylinositol acyl-chain remodeling	"Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains." [GOC:mw, PMID:18094042, PMID:18772128]	PANTHER
NV2t019966001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019967001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019967001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019967001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019967002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019967002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019969001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t019969001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t019969001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t019970001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t019970001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t019970001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	OMA
NV2t019970001.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	PANTHER
NV2t019970001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019970002.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	PANTHER
NV2t019970003.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	PANTHER
NV2t019970004.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t019970004.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	PANTHER
NV2t019970006.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	PANTHER
NV2t019970007.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t019970007.1	biological_process	GO:0007034	vacuolar transport	"The directed movement of substances into, out of or within a vacuole." [GOC:ai]	PANTHER
NV2t019971001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019971001.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	OMA
NV2t019971001.1	biological_process	GO:0042558	pteridine-containing compound metabolic process	"The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019971001.1	biological_process	GO:0042558	pteridine-containing compound metabolic process	"The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]	OMA
NV2t019971001.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t019971001.1	biological_process	GO:0050667	homocysteine metabolic process	"The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732]	PANTHER
NV2t019971001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t019971001.1	molecular_function	GO:0008172	S-methyltransferase activity	"Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai]	OMA
NV2t019971001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019971001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t019971001.1	molecular_function	GO:0031419	cobalamin binding	"Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]	InterPro
NV2t019971001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019971001.1	molecular_function	GO:0046906	tetrapyrrole binding	"Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [GOC:curators, ISBN:0198506732]	OMA
NV2t019971002.1	biological_process	GO:0009086	methionine biosynthetic process	"The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019971002.1	biological_process	GO:0042558	pteridine-containing compound metabolic process	"The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]	InterPro
NV2t019971002.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	InterPro
NV2t019971002.1	biological_process	GO:0050667	homocysteine metabolic process	"The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732]	PANTHER
NV2t019971002.1	molecular_function	GO:0031419	cobalamin binding	"Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]	InterPro
NV2t019971002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t019973001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t019973001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t019973001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t019973001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t019973001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019973001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019973001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019973001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t019973002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t019973002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019973002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019973003.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t019973003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t019973003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t019975001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019975001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019976001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019976001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019977001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019977001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019977001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t019978001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t019978001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t019978001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t019978001.1	molecular_function	GO:0004300	enoyl-CoA hydratase activity	"Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17]	OMA
NV2t019979001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019979002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019980001.1	biological_process	GO:0010269	response to selenium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg]	PANTHER
NV2t019983001.1	molecular_function	GO:0008119	thiopurine S-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]	PANTHER
NV2t019983001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t019983001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t019984001.1	molecular_function	GO:0008119	thiopurine S-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]	PANTHER
NV2t019984001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t019986001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t019987001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t019987001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t019987001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019987001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t019987001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t019987001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t019987001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t019988001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t019988001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t019988001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t019988001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t019989001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t019989001.1	biological_process	GO:0003006	developmental process involved in reproduction	"A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]	OMA
NV2t019989001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t019989001.1	biological_process	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	OMA
NV2t019989001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t019989001.1	biological_process	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t019989001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t019989001.1	biological_process	GO:0031328	positive regulation of cellular biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t019989001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t019989001.1	biological_process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	"Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]	OMA
NV2t019989001.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t019989001.1	biological_process	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t019989001.1	biological_process	GO:0048609	multicellular organismal reproductive process	"The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t019989001.1	biological_process	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t019989001.1	biological_process	GO:0051173	obsolete positive regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t019989001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t019989001.1	biological_process	GO:0070212	protein poly-ADP-ribosylation	"The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain." [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]	OMA
NV2t019989001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t019989001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t019989001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t019989001.1	cellular_component	GO:0043596	nuclear replication fork	"The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]	OMA
NV2t019989001.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	OMA
NV2t019989001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t019989001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t019989001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t019989001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t019989001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t019989001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t019989001.1	molecular_function	GO:0031491	nucleosome binding	"Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]	OMA
NV2t019989001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t019989001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t019989001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	OMA
NV2t019989001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	PANTHER
NV2t019990001.1	molecular_function	GO:0017136	NAD-dependent histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [PMID:28450737]	OMA
NV2t019990001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t019990001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t019990001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t019990001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t019993001.1	biological_process	GO:0009744	response to sucrose	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]	OMA
NV2t019993001.1	biological_process	GO:0009749	response to glucose	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl]	OMA
NV2t019993001.1	biological_process	GO:0009750	response to fructose	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl]	OMA
NV2t019993001.1	biological_process	GO:0010043	response to zinc ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]	OMA
NV2t019993001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t019993001.1	biological_process	GO:0032868	response to insulin	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t019993001.1	biological_process	GO:0070873	regulation of glycogen metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]	OMA
NV2t019993001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t019993001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t019993001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t019993001.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t019997001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t019997002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t019997003.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t019998001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019998002.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019998003.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019998004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019998005.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t019998006.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020000001.1	cellular_component	GO:0036128	CatSper complex	"A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039]	InterPro
NV2t020000001.1	cellular_component	GO:0097228	sperm principal piece	"The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836]	PANTHER
NV2t020002001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t020002001.1	biological_process	GO:0045951	positive regulation of mitotic recombination	"Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators]	PANTHER
NV2t020002001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020002001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t020002001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	InterPro
NV2t020002001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t020002001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020002001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020002001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t020002001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020002001.1	molecular_function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	InterPro
NV2t020002001.1	molecular_function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	OMA
NV2t020006001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020006001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t020006001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t020006001.1	molecular_function	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	"Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732]	OMA
NV2t020007001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t020007001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t020007001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t020007001.1	biological_process	GO:0010720	positive regulation of cell development	"Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t020007001.1	biological_process	GO:0030865	cortical cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020007001.1	biological_process	GO:0035303	regulation of dephosphorylation	"Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]	OMA
NV2t020007001.1	biological_process	GO:0045579	positive regulation of B cell differentiation	"Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators]	PANTHER
NV2t020007001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t020007001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t020007001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t020007001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t020007001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t020009001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t020009001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t020009001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t020009001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t020010001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t020010001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020010001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t020012001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t020012002.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t020013001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t020013001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t020013001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t020013001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020013002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020014001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020015001.1	cellular_component	GO:1990023	mitotic spindle midzone	"The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw]	PANTHER
NV2t020016001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020017001.1	biological_process	GO:0046654	tetrahydrofolate biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732]	InterPro
NV2t020020001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t020029001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t020029001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020030001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020030001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t020031001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t020031001.1	biological_process	GO:0009312	oligosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t020031001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t020031001.1	cellular_component	GO:0005795	Golgi stack	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]	OMA
NV2t020031001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020031001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	OMA
NV2t020031001.1	molecular_function	GO:0140103	catalytic activity, acting on a glycoprotein	"Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t020035001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t020035001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	PANTHER
NV2t020038001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t020038001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	InterPro
NV2t020038001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t020039001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020039002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020039003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020040001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	InterPro
NV2t020040001.1	biological_process	GO:0006298	mismatch repair	"A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886]	OMA
NV2t020040001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t020040001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t020040001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t020040001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020040001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020040001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t020040001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t020040001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t020040001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t020040001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t020041001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020041001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t020041001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t020041001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t020041001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t020041001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t020041001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t020042001.1	biological_process	GO:0006014	D-ribose metabolic process	"The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732]	InterPro
NV2t020042001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t020042002.1	biological_process	GO:0006014	D-ribose metabolic process	"The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732]	InterPro
NV2t020042002.1	biological_process	GO:0019321	pentose metabolic process	"The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t020042002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t020042002.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t020042002.1	molecular_function	GO:0019200	carbohydrate kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]	OMA
NV2t020042002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t020045001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020047001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	InterPro
NV2t020048001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t020048001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t020048001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t020048001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t020048001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t020048001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t020048001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	OMA
NV2t020049001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t020049001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020049001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t020049001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t020049001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t020049001.1	molecular_function	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	"Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265]	OMA
NV2t020049001.1	molecular_function	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	"Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265]	PANTHER
NV2t020049002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t020049002.1	molecular_function	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	"Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265]	PANTHER
NV2t020050001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t020050001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020051001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020051001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t020051001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t020051001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	PANTHER
NV2t020051001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020054001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t020055001.1	biological_process	GO:0097191	extrinsic apoptotic signaling pathway	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152]	PANTHER
NV2t020056001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t020056001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	PANTHER
NV2t020056001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020059001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020060001.1	biological_process	GO:0034470	obsolete ncRNA processing	"OBSOLETE. Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah, PMID:27573892]	OMA
NV2t020060001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t020060001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t020060001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t020060001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t020060001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020060001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020060001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020061001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020063001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t020063001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t020063001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	PANTHER
NV2t020064001.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	PANTHER
NV2t020064002.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	PANTHER
NV2t020064003.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	PANTHER
NV2t020064004.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	PANTHER
NV2t020065001.1	molecular_function	GO:0008301	DNA binding, bending	"The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]	PANTHER
NV2t020066001.1	biological_process	GO:0000958	mitochondrial mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]	OMA
NV2t020066001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020066001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	InterPro
NV2t020066001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t020066001.1	biological_process	GO:0043457	regulation of cellular respiration	"Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl]	OMA
NV2t020066001.1	biological_process	GO:0043633	polyadenylation-dependent RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA." [GOC:dgf, GOC:jl, GOC:krc]	OMA
NV2t020066001.1	biological_process	GO:0045926	negative regulation of growth	"Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]	OMA
NV2t020066001.1	biological_process	GO:0050658	RNA transport	"The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t020066001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t020066001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t020066001.1	biological_process	GO:0061157	mRNA destabilization	"Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh]	OMA
NV2t020066001.1	biological_process	GO:0070584	obsolete mitochondrion morphogenesis	"OBSOLETE. The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah]	OMA
NV2t020066001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t020066001.1	biological_process	GO:0097222	mitochondrial mRNA polyadenylation	"The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails." [GOC:ans, PMID:18083837]	OMA
NV2t020066001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t020066001.1	biological_process	GO:2000627	positive regulation of miRNA catabolic process	"Any process that activates or increases the frequency, rate or extent of miRNA catabolic process." [GOC:dph]	OMA
NV2t020066001.1	cellular_component	GO:0000178	exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t020066001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t020066001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020066001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t020066001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t020066001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020066001.1	molecular_function	GO:0008266	poly(U) RNA binding	"Binding to a sequence of uracil residues in an RNA molecule." [GOC:mah]	OMA
NV2t020066001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	OMA
NV2t020066001.1	molecular_function	GO:0035198	miRNA binding	"Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]	OMA
NV2t020066001.1	molecular_function	GO:0070717	poly-purine tract binding	"Binding to a stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah]	OMA
NV2t020066002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020066002.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	InterPro
NV2t020067001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	InterPro
NV2t020067001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020067001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020068001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	OMA
NV2t020068001.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t020068001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020068001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t020068001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t020068002.1	biological_process	GO:0051923	sulfation	"The addition of a sulfate group to a molecule." [Wikipedia:Sulfation]	PANTHER
NV2t020068002.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t020070001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020070001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t020070001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t020070001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t020070001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t020070001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t020070001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t020070001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t020071001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020075001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t020075001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020075001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t020075001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t020075001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020075002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020075002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t020077001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020077001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t020079001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	InterPro
NV2t020079001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	OMA
NV2t020079001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t020079001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t020079001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t020084001.1	biological_process	GO:0006690	icosanoid metabolic process	"The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma]	OMA
NV2t020084001.1	biological_process	GO:0046942	carboxylic acid transport	"The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]	OMA
NV2t020084001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020084001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020084001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t020084001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020084001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t020084001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020084001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t020084001.1	molecular_function	GO:1901682	sulfur compound transmembrane transporter activity	"Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t020086001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020086001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t020086001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020090004.1	biological_process	GO:2000001	regulation of DNA damage checkpoint	"Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]	PANTHER
NV2t020091001.1	biological_process	GO:0006694	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	OMA
NV2t020091001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020091001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020091001.1	molecular_function	GO:0016229	steroid dehydrogenase activity	"Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]	OMA
NV2t020091001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t020091001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t020091001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t020092001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t020092001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t020092001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t020092001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020092001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020095001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020095001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020095001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020095001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020095001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020097001.1	biological_process	GO:0003008	system process	"A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]	OMA
NV2t020097001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t020097001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t020097001.1	biological_process	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	OMA
NV2t020097001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020097001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t020097001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020097001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t020097001.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t020097001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	OMA
NV2t020097001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t020097001.1	molecular_function	GO:0005432	calcium:sodium antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]	OMA
NV2t020097001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020099001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t020099001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020099001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	PANTHER
NV2t020101001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	PANTHER
NV2t020103001.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	InterPro
NV2t020103001.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	OMA
NV2t020103001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t020103001.1	molecular_function	GO:0051765	inositol tetrakisphosphate kinase activity	"Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai]	PANTHER
NV2t020105001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020105001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020105001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t020105002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020105002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020106001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020108001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t020108001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020108001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t020109001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020109001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t020110001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t020110001.1	biological_process	GO:0006952	defense response	"Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]	OMA
NV2t020110001.1	biological_process	GO:0048266	behavioral response to pain	"Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid]	OMA
NV2t020110001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020110001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t020110001.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t020110001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t020110001.1	molecular_function	GO:0005248	voltage-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020111001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020111001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t020112001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t020112001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020112001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t020113001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t020113001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020113001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t020113001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020113001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t020113001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t020113001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020113001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020115001.1	molecular_function	GO:0019171	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	"Catalysis of the reaction: a (3R)-hydroxyacyl-[acyl-carrier-protein] = a (2E)-enoyl-[acyl-carrier-protein] + H2O." [RHEA:13097]	PANTHER
NV2t020116001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020118001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020118001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t020119001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020119001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t020120001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020120001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020120001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t020121001.1	biological_process	GO:0007019	microtubule depolymerization	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]	OMA
NV2t020121001.1	biological_process	GO:1901673	regulation of mitotic spindle assembly	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]	OMA
NV2t020121001.1	biological_process	GO:1901673	regulation of mitotic spindle assembly	"Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie]	PANTHER
NV2t020121001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t020121001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t020121001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t020121001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t020121001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t020121001.1	cellular_component	GO:0035869	ciliary transition zone	"A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230]	OMA
NV2t020121001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t020121001.1	cellular_component	GO:0061673	mitotic spindle astral microtubule	"Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph]	OMA
NV2t020121001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t020122001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t020122001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t020122001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020122001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020122001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020124001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t020124001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020124002.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t020124002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020124003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020124004.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t020124004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020124005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020125003.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	OMA
NV2t020125003.1	cellular_component	GO:0044666	MLL3/4 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t020125003.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	OMA
NV2t020126001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020126001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t020128001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020129001.1	biological_process	GO:0097250	mitochondrial respirasome assembly	"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]	PANTHER
NV2t020131001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t020131001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020131001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020132001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t020132002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t020134001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020135001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t020135001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t020135001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t020135001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020135001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t020135001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	PANTHER
NV2t020135001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	InterPro
NV2t020135001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t020135001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020135001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020136001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020138001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020138001.1	biological_process	GO:0030203	glycosaminoglycan metabolic process	"The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	PANTHER
NV2t020138001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020138002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020138003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020138004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020139001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t020139001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020139002.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t020139002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020140001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020140001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020140001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020140001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t020140001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020140002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020140002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020140002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020140004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020140004.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020140004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020140005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020140005.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020140005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020140006.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020140006.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020140006.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020141001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020141001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020141001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020144001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020144001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020144001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020144002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020144002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020144003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020144003.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020144003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020144004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020144004.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020144004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020144005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020144005.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t020144005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020144006.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020144006.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020145001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	PANTHER
NV2t020146001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020146001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020146001.1	biological_process	GO:0008366	axon ensheathment	"Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]	OMA
NV2t020146001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t020146001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	PANTHER
NV2t020146001.1	molecular_function	GO:0016859	cis-trans isomerase activity	"Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732]	OMA
NV2t020146001.1	molecular_function	GO:0042284	sphingolipid delta-4 desaturase activity	"Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O." [PMID:12417141, RHEA:46544]	InterPro
NV2t020146001.1	molecular_function	GO:0042284	sphingolipid delta-4 desaturase activity	"Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O." [PMID:12417141, RHEA:46544]	OMA
NV2t020147001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020147001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020147001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t020147002.1	biological_process	GO:0106035	protein maturation by [4Fe-4S] cluster transfer	"The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]	PANTHER
NV2t020147002.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t020147003.1	biological_process	GO:0106035	protein maturation by [4Fe-4S] cluster transfer	"The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]	PANTHER
NV2t020147003.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t020148001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020149001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020149001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020150001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020150001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t020151001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020151001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	PANTHER
NV2t020151001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020151001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020152001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020153001.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t020153002.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t020153003.1	biological_process	GO:1902476	chloride transmembrane transport	"The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw]	PANTHER
NV2t020155001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020155001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t020155002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t020155003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t020156001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t020156001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020156001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	InterPro
NV2t020156001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t020156001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t020157001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t020157001.1	molecular_function	GO:0071933	Arp2/3 complex binding	"Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)." [GOC:mah]	InterPro
NV2t020158001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t020158001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t020158002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t020159001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020159001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020159001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020159001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020161001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020162001.1	biological_process	GO:0045003	double-strand break repair via synthesis-dependent strand annealing	"SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]	PANTHER
NV2t020162001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020162001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	InterPro
NV2t020164001.1	biological_process	GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair	"Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477]	PANTHER
NV2t020164001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t020165001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t020165001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	PANTHER
NV2t020165002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t020165002.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	PANTHER
NV2t020165003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t020165003.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	PANTHER
NV2t020166001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020166002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020168001.1	biological_process	GO:0033108	mitochondrial respiratory chain complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]	PANTHER
NV2t020169001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t020169001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t020169001.1	biological_process	GO:0035494	SNARE complex disassembly	"The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877]	PANTHER
NV2t020169001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020173001.1	biological_process	GO:0033108	mitochondrial respiratory chain complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]	OMA
NV2t020173001.1	biological_process	GO:0033108	mitochondrial respiratory chain complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]	PANTHER
NV2t020173001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020174001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t020174001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t020174001.1	biological_process	GO:0035494	SNARE complex disassembly	"The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877]	PANTHER
NV2t020174001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020175001.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t020175001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020175001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020176001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t020176001.1	molecular_function	GO:1990189	peptide-serine-alpha-N-acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide." [GOC:al, PMID:23912279]	PANTHER
NV2t020178001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t020178001.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t020178001.1	biological_process	GO:0046040	IMP metabolic process	"The chemical reactions and pathways involving IMP, inosine monophosphate." [GOC:go_curators]	PANTHER
NV2t020178001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020178001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020178001.1	molecular_function	GO:0016879	ligase activity, forming carbon-nitrogen bonds	"Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah]	OMA
NV2t020180001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t020180001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020180001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t020186001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020187001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020188001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t020188001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t020188001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t020188001.1	molecular_function	GO:0004896	cytokine receptor activity	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]	OMA
NV2t020188001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020188001.1	molecular_function	GO:0019955	cytokine binding	"Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]	OMA
NV2t020188002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t020188002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020188003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t020188003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020188004.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t020188004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020190001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t020190001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t020190001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020190001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t020190001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t020190001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t020190001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t020190001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020194001.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	PANTHER
NV2t020194002.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	PANTHER
NV2t020194003.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	PANTHER
NV2t020194004.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	PANTHER
NV2t020194005.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	PANTHER
NV2t020194006.1	biological_process	GO:0008154	actin polymerization or depolymerization	"Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t020194006.1	biological_process	GO:0010633	negative regulation of epithelial cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t020194006.1	biological_process	GO:0030838	positive regulation of actin filament polymerization	"Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah]	OMA
NV2t020194006.1	biological_process	GO:0045010	actin nucleation	"The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]	OMA
NV2t020194006.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t020194006.1	biological_process	GO:0051496	positive regulation of stress fiber assembly	"Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	OMA
NV2t020194006.1	biological_process	GO:0120033	negative regulation of plasma membrane bounded cell projection assembly	"Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc]	OMA
NV2t020194006.1	biological_process	GO:1900027	regulation of ruffle assembly	"Any process that modulates the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf]	OMA
NV2t020194006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020194006.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t020194006.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t020194006.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t020194006.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t020194006.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	OMA
NV2t020194006.1	molecular_function	GO:0017124	SH3 domain binding	"Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]	PANTHER
NV2t020195001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020195001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020196001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	OMA
NV2t020196001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020196001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020196001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t020196001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020196001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020201001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020201001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020201001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020201001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t020201002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020201002.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	OMA
NV2t020201002.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t020201002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020201002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020201002.1	molecular_function	GO:0005217	intracellularly ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020201002.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t020201002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020201002.1	molecular_function	GO:0015562	efflux transmembrane transporter activity	"Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020201002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020201002.1	molecular_function	GO:0099095	ligand-gated monoatomic anion channel activity	"Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020201002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t020201002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t020201003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020201003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020202001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t020202001.1	biological_process	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t020202001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t020202001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t020202001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	OMA
NV2t020202001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t020202001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t020202001.1	biological_process	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t020202001.1	biological_process	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t020202001.1	biological_process	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	OMA
NV2t020202001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t020202001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t020202001.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	OMA
NV2t020202001.1	cellular_component	GO:0071203	WASH complex	"A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]	PANTHER
NV2t020202001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t020202001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t020202001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	OMA
NV2t020203001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t020203001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020203001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t020204001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	OMA
NV2t020204001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t020204001.1	biological_process	GO:0046339	diacylglycerol metabolic process	"The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11481335]	OMA
NV2t020204001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t020204001.1	cellular_component	GO:0097038	perinuclear endoplasmic reticulum	"The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]	OMA
NV2t020204001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t020204001.1	molecular_function	GO:0016411	acylglycerol O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]	OMA
NV2t020205001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t020205001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t020205001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020205001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020205001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020205001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t020205001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t020206001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t020206001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020206002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t020206002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t020206002.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t020206002.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t020206002.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t020206002.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t020206002.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t020206002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020206002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020206002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020206002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t020206003.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t020206003.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t020206003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020206003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020206004.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t020206004.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t020206004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020206004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020211001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020211001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020211001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020213001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020213001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t020213001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t020213001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t020213001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t020213001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t020213001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t020215001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t020215001.1	biological_process	GO:0006108	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t020215001.1	biological_process	GO:0006734	NADH metabolic process	"The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t020215001.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	InterPro
NV2t020215001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020215001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020215001.1	molecular_function	GO:0016615	malate dehydrogenase activity	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]	InterPro
NV2t020215001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t020215001.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	InterPro
NV2t020215001.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	OMA
NV2t020215001.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	PANTHER
NV2t020215002.1	biological_process	GO:0019752	carboxylic acid metabolic process	"The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	InterPro
NV2t020215002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020215002.1	molecular_function	GO:0016615	malate dehydrogenase activity	"Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]	InterPro
NV2t020215002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t020215002.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	InterPro
NV2t020215002.1	molecular_function	GO:0030060	L-malate dehydrogenase activity	"Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37]	PANTHER
NV2t020219001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	InterPro
NV2t020219001.1	biological_process	GO:0035148	tube formation	"Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf]	PANTHER
NV2t020220001.1	biological_process	GO:0006309	apoptotic DNA fragmentation	"The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]	PANTHER
NV2t020220001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t020220001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t020220001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020220001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020224001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020224001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020224001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t020224001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t020224001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t020224001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020226001.1	biological_process	GO:0043045	epigenetic programming of gene expression	"A epigenetic process that happens during embryonic development that modulates gene expression potential at later stages of development of the organism, including the adult. Epigenetic regulation takes place via chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or cytosine DNA methylation." [GOC:go_curators, PMID:12138111, PMID:22868271]	OMA
NV2t020226001.1	biological_process	GO:1901537	positive regulation of DNA demethylation	"Any process that activates or increases the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]	OMA
NV2t020226001.1	biological_process	GO:1901537	positive regulation of DNA demethylation	"Any process that activates or increases the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]	PANTHER
NV2t020226001.1	cellular_component	GO:0001940	male pronucleus	"The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]	OMA
NV2t020226001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020226001.1	cellular_component	GO:0042585	germinal vesicle	"The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837]	OMA
NV2t020226001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t020226001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t020226002.1	biological_process	GO:1901537	positive regulation of DNA demethylation	"Any process that activates or increases the frequency, rate or extent of DNA demethylation." [GOC:TermGenie]	PANTHER
NV2t020227001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020227001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020228001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t020228001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020228001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t020229001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020231001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t020231001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t020232001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020232001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t020236001.1	cellular_component	GO:0017054	negative cofactor 2 complex	"A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413]	PANTHER
NV2t020236001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t020236001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t020236001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t020238001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t020238001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t020238001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	PANTHER
NV2t020238001.1	cellular_component	GO:0005658	alpha DNA polymerase:primase complex	"A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377]	OMA
NV2t020238001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t020239001.1	biological_process	GO:0055001	muscle cell development	"The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]	PANTHER
NV2t020239001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020239001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020241001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t020241001.1	biological_process	GO:0006999	nuclear pore organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]	OMA
NV2t020241001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t020241001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t020241001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020241001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t020241001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t020241001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t020241001.1	cellular_component	GO:0031080	nuclear pore outer ring	"A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	PANTHER
NV2t020241001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020241001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	OMA
NV2t020244001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020244001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020246001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t020246001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t020246001.1	biological_process	GO:0043551	obsolete regulation of phosphatidylinositol 3-kinase activity	"OBSOLETE. Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf]	OMA
NV2t020246001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	OMA
NV2t020246001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t020246001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t020246001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t020246001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020246001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t020246001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020246001.1	cellular_component	GO:0031312	extrinsic component of organelle membrane	"The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]	OMA
NV2t020246001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t020246001.1	cellular_component	GO:0031902	late endosome membrane	"The lipid bilayer surrounding a late endosome." [GOC:pz]	OMA
NV2t020246001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020246001.1	molecular_function	GO:0019207	kinase regulator activity	"Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]	OMA
NV2t020246001.1	molecular_function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341]	OMA
NV2t020246002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020247001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	InterPro
NV2t020247001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t020247001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t020247001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t020247001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t020247001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t020249001.1	biological_process	GO:0019216	regulation of lipid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]	OMA
NV2t020249001.1	biological_process	GO:0019216	regulation of lipid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]	PANTHER
NV2t020249001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	OMA
NV2t020249001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020250001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t020250001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t020250001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020250001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t020250001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t020250001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t020250001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t020250001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t020250001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t020251001.1	biological_process	GO:0000712	resolution of meiotic recombination intermediates	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]	OMA
NV2t020251001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t020251001.1	biological_process	GO:0000737	obsolete DNA catabolic process, endonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]	OMA
NV2t020251001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t020251001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t020251001.1	biological_process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]	OMA
NV2t020251001.1	biological_process	GO:0071216	cellular response to biotic stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]	OMA
NV2t020251001.1	biological_process	GO:0071495	cellular response to endogenous stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]	OMA
NV2t020251001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020251001.1	cellular_component	GO:0048476	Holliday junction resolvase complex	"An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated." [PMID:11207366, PMID:12374758]	PANTHER
NV2t020251001.1	cellular_component	GO:1905348	endonuclease complex	"A protein complex which is capable of endonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]	OMA
NV2t020251001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t020251001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t020251001.1	molecular_function	GO:0008821	crossover junction DNA endonuclease activity	"Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.21.10]	OMA
NV2t020251001.1	molecular_function	GO:0048256	flap endonuclease activity	"Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid]	OMA
NV2t020252001.1	biological_process	GO:0014059	regulation of dopamine secretion	"Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]	OMA
NV2t020252001.1	biological_process	GO:0017156	calcium-ion regulated exocytosis	"The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]	OMA
NV2t020252001.1	biological_process	GO:0017158	regulation of calcium ion-dependent exocytosis	"Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]	OMA
NV2t020252001.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t020252001.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t020252001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t020252001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t020252001.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t020252001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020252001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020252001.1	cellular_component	GO:0070382	exocytic vesicle	"A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]	OMA
NV2t020252001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t020252001.1	molecular_function	GO:0001786	phosphatidylserine binding	"Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]	OMA
NV2t020252001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020252001.1	molecular_function	GO:0005544	calcium-dependent phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]	OMA
NV2t020252001.1	molecular_function	GO:0030276	clathrin binding	"Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]	OMA
NV2t020254001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t020254001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020254001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020254001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020255001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t020255001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020255001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020255001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020260001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020261001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020261001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t020261001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t020261001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t020264001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	PANTHER
NV2t020264002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	PANTHER
NV2t020266001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	InterPro
NV2t020266001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	OMA
NV2t020266001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t020266001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t020266001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	PANTHER
NV2t020266001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020266001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t020266001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t020267001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020268001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020268001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t020268001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020268001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t020268001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020268001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020268001.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t020270001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t020270001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t020270001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t020270001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t020271001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020271003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020271004.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020271005.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020271006.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020271007.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020272001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	InterPro
NV2t020273001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t020273001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t020273001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020273001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t020273001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t020273001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t020273001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t020273001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t020274001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t020276001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t020277001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020277001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020277002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020277002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t020277002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t020277002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020277002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020277003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020277003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020277004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020277004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020278001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020278001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020279001.1	biological_process	GO:0033209	tumor necrosis factor-mediated signaling pathway	"The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t020279001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t020279001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t020279001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t020279001.1	biological_process	GO:0046330	positive regulation of JNK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	OMA
NV2t020279001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t020279001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t020279001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020279001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020279001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020279001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t020279001.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t020280001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020280002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020281001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t020281001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t020281001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t020281001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t020281001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t020283001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020283001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020283001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020287001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t020287001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t020287001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t020287001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t020287001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t020287001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t020287001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t020287001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020287001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t020287001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t020287001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t020287001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t020288001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020288001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020290001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	PANTHER
NV2t020290001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020291001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t020291001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t020291001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t020291001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t020291001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t020291001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t020291001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t020292001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t020292001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t020292001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t020292001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t020292001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t020292001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t020292001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t020292003.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t020292003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t020292003.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t020296001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t020299001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	PANTHER
NV2t020300001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t020300001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t020300001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	InterPro
NV2t020300001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	OMA
NV2t020300001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020300001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020300001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t020301001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020301001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020301001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t020301002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020301003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020301004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020302001.1	biological_process	GO:0090656	t-circle formation	"A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD)." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19214183, PMID:19581589, PMID:19809492, PMID:19858100]	PANTHER
NV2t020302001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t020302002.1	biological_process	GO:0090656	t-circle formation	"A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD)." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19214183, PMID:19581589, PMID:19809492, PMID:19858100]	PANTHER
NV2t020302002.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t020303001.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	InterPro
NV2t020303002.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	InterPro
NV2t020303003.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	InterPro
NV2t020303004.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	InterPro
NV2t020303004.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t020303005.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	InterPro
NV2t020303006.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	InterPro
NV2t020303007.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	InterPro
NV2t020304001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	OMA
NV2t020304001.1	cellular_component	GO:0030532	small nuclear ribonucleoprotein complex	"A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]	InterPro
NV2t020304001.1	cellular_component	GO:0030532	small nuclear ribonucleoprotein complex	"A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t020304001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t020304001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020305001.1	cellular_component	GO:0097526	spliceosomal tri-snRNP complex	"A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]	PANTHER
NV2t020306001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020306001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020306002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020308001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t020308001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020309001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t020309001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t020309001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t020309001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020309001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t020311002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311002.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311003.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311003.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311004.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311004.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t020311004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020311004.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311005.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311005.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311006.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311006.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311007.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311007.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311008.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311008.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311009.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311009.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311010.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311010.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311011.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311011.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311012.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311012.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020311013.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020311013.1	cellular_component	GO:0071004	U2-type prespliceosome	"A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]	PANTHER
NV2t020311013.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020312001.1	molecular_function	GO:0017174	glycine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]	InterPro
NV2t020312001.1	molecular_function	GO:1904047	S-adenosyl-L-methionine binding	"Binding to S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]	PANTHER
NV2t020312002.1	biological_process	GO:0006730	one-carbon metabolic process	"The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]	OMA
NV2t020312002.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	OMA
NV2t020312002.1	biological_process	GO:0043255	regulation of carbohydrate biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]	OMA
NV2t020312002.1	biological_process	GO:0046498	S-adenosylhomocysteine metabolic process	"The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine." [ISBN:0198506732]	OMA
NV2t020312002.1	biological_process	GO:0046500	S-adenosylmethionine metabolic process	"The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t020312002.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t020312002.1	biological_process	GO:1901052	sarcosine metabolic process	"The chemical reactions and pathways involving sarcosine." [GOC:TermGenie, GOC:yaf, PMID:17951379]	OMA
NV2t020312002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020312002.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t020312002.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t020312002.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t020312002.1	molecular_function	GO:0017174	glycine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]	InterPro
NV2t020312002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t020312002.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t020312002.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t020312002.1	molecular_function	GO:1904047	S-adenosyl-L-methionine binding	"Binding to S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]	PANTHER
NV2t020312003.1	molecular_function	GO:0017174	glycine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]	InterPro
NV2t020312003.1	molecular_function	GO:1904047	S-adenosyl-L-methionine binding	"Binding to S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]	PANTHER
NV2t020312004.1	molecular_function	GO:0017174	glycine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]	InterPro
NV2t020312004.1	molecular_function	GO:1904047	S-adenosyl-L-methionine binding	"Binding to S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]	PANTHER
NV2t020312005.1	molecular_function	GO:0017174	glycine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]	InterPro
NV2t020312005.1	molecular_function	GO:1904047	S-adenosyl-L-methionine binding	"Binding to S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]	PANTHER
NV2t020313001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t020313001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	PANTHER
NV2t020313001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t020313001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t020313001.1	molecular_function	GO:0030165	PDZ domain binding	"Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]	OMA
NV2t020315001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020315001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t020315001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t020315001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t020315001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t020315001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020318001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t020318001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t020318001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t020319001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020319001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t020322001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	PANTHER
NV2t020323001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	PANTHER
NV2t020323002.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	PANTHER
NV2t020324001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t020324001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t020324001.1	cellular_component	GO:0005834	heterotrimeric G-protein complex	"Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684]	OMA
NV2t020324001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t020324001.1	molecular_function	GO:0031681	G-protein beta-subunit binding	"Binding to a G-protein beta subunit." [GOC:mah]	InterPro
NV2t020324002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t020324002.1	molecular_function	GO:0031681	G-protein beta-subunit binding	"Binding to a G-protein beta subunit." [GOC:mah]	InterPro
NV2t020327001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t020327001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020327001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020328001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020328001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020328001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t020329001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020329001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020329001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t020330001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t020330001.1	molecular_function	GO:0004090	carbonyl reductase (NADPH) activity	"Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]	OMA
NV2t020330001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020330001.1	molecular_function	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	"Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25033]	OMA
NV2t020331002.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t020331002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t020331002.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	OMA
NV2t020331002.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t020331002.1	cellular_component	GO:0005669	transcription factor TFIID complex	"A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]	OMA
NV2t020331002.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t020331002.1	molecular_function	GO:0001091	RNA polymerase II general transcription initiation factor binding	"Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867]	OMA
NV2t020331002.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	OMA
NV2t020331002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t020331002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020331002.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t020331002.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	OMA
NV2t020331003.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t020332001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020333001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t020333001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	PANTHER
NV2t020333001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t020333001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t020333001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020334001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	InterPro
NV2t020335001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t020335002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020335002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020335002.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	PANTHER
NV2t020335003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020335003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020335003.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	PANTHER
NV2t020335004.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020335004.1	biological_process	GO:0006636	unsaturated fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]	OMA
NV2t020335004.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020335004.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	OMA
NV2t020335004.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	PANTHER
NV2t020335005.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020335005.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020335005.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	PANTHER
NV2t020337001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t020337001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t020337001.1	biological_process	GO:0044743	protein transmembrane import into intracellular organelle	"The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]	OMA
NV2t020337001.1	biological_process	GO:0050658	RNA transport	"The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t020337001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t020337001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t020337001.1	cellular_component	GO:0031307	obsolete integral component of mitochondrial outer membrane	"OBSOLETE. The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t020337001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t020337001.1	cellular_component	GO:0044233	mitochondria-associated endoplasmic reticulum membrane contact site	"A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109]	OMA
NV2t020337001.1	cellular_component	GO:0098799	outer mitochondrial membrane protein complex	"Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos]	OMA
NV2t020337001.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t020337001.1	molecular_function	GO:0022884	macromolecule transmembrane transporter activity	"Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020337001.1	molecular_function	GO:0042626	ATPase-coupled transmembrane transporter activity	"Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020337001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t020337001.1	molecular_function	GO:0140318	protein transporter activity	"Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]	OMA
NV2t020338001.1	biological_process	GO:0036158	outer dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	PANTHER
NV2t020338001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020340001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t020340001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t020340001.1	cellular_component	GO:0000159	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	OMA
NV2t020340001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020340001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020340001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t020340001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	InterPro
NV2t020340001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t020340001.1	molecular_function	GO:0072542	protein phosphatase activator activity	"Binds to and increases the activity of a protein phosphatase." [GOC:mah]	PANTHER
NV2t020341001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020341001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t020341001.1	molecular_function	GO:0019838	growth factor binding	"Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators]	OMA
NV2t020345001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t020345001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t020345001.1	biological_process	GO:0051246	regulation of protein metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t020345001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020345001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t020345001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t020345001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020345001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t020346001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020349001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t020349001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t020349002.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t020351001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t020351001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020351002.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t020351002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020351002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020353001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	OMA
NV2t020353001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t020353001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020353001.1	molecular_function	GO:0004521	RNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t020353001.1	molecular_function	GO:0016849	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t020353001.1	molecular_function	GO:0033897	ribonuclease T2 activity	"Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.19]	InterPro
NV2t020354001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t020354001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t020354001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t020354001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	PANTHER
NV2t020355001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020355001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	PANTHER
NV2t020355002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020355002.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	PANTHER
NV2t020355003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020355003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t020355003.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t020355003.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t020355003.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t020355003.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t020355003.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	PANTHER
NV2t020356001.1	biological_process	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	"Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]	OMA
NV2t020356001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t020356001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t020356001.1	biological_process	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	InterPro
NV2t020356001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t020356001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t020356001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t020356001.1	molecular_function	GO:0004435	phosphatidylinositol phospholipase C activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+." [EC:3.1.4.11, RHEA:33179]	OMA
NV2t020356001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020356001.1	molecular_function	GO:0030371	translation repressor activity	"Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt]	InterPro
NV2t020356001.1	molecular_function	GO:0030371	translation repressor activity	"Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt]	OMA
NV2t020357001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	InterPro
NV2t020357001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	PANTHER
NV2t020359001.1	biological_process	GO:0031648	protein destabilization	"Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]	OMA
NV2t020359001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020359001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020359001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020360001.1	biological_process	GO:0006071	glycerol metabolic process	"The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732]	InterPro
NV2t020360001.1	biological_process	GO:0019563	glycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t020362001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020362001.1	molecular_function	GO:0019208	phosphatase regulator activity	"Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]	PANTHER
NV2t020363001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020363001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020363001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020363001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020364001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t020364001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020364001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020364001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t020364001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t020364001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t020364001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t020364002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020364002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t020366001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020366001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020366001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t020368001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t020368001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020368001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020368001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t020368001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t020368001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t020368001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t020369001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020370001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020371001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020371001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020371001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t020371001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020371001.1	molecular_function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	OMA
NV2t020371001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020371001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020373001.1	biological_process	GO:0097720	calcineurin-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]	PANTHER
NV2t020373001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020375001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020375001.1	molecular_function	GO:0090599	alpha-glucosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose." [GOC:tb]	PANTHER
NV2t020377001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	PANTHER
NV2t020379001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020379001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020379001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t020379001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t020379001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020379001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020382001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020384001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	PANTHER
NV2t020389001.1	biological_process	GO:0007096	regulation of exit from mitosis	"Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]	InterPro
NV2t020389001.1	biological_process	GO:0007096	regulation of exit from mitosis	"Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]	OMA
NV2t020389001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020393001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020393001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020394001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t020395001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t020395002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t020396002.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t020396002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020396003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020396004.1	cellular_component	GO:0070971	endoplasmic reticulum exit site	"An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]	PANTHER
NV2t020397001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t020397001.1	biological_process	GO:0032324	molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]	OMA
NV2t020397001.1	biological_process	GO:0032447	protein urmylation	"Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw]	OMA
NV2t020397001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020397001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t020397001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	OMA
NV2t020397001.1	molecular_function	GO:0016783	sulfurtransferase activity	"Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544]	OMA
NV2t020397001.1	molecular_function	GO:0042292	URM1 activating enzyme activity	"Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]	PANTHER
NV2t020397001.1	molecular_function	GO:0070566	adenylyltransferase activity	"Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]	InterPro
NV2t020397001.1	molecular_function	GO:0070733	AMPylase activity	"Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins." [GOC:mah, PMID:19039103, PMID:19362538, PMID:33947243]	OMA
NV2t020399001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	InterPro
NV2t020399002.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	InterPro
NV2t020400001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t020400001.1	molecular_function	GO:0042292	URM1 activating enzyme activity	"Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]	PANTHER
NV2t020400002.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t020400002.1	molecular_function	GO:0042292	URM1 activating enzyme activity	"Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]	PANTHER
NV2t020401001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	InterPro
NV2t020401002.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	InterPro
NV2t020402001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020402001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020402001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020402001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020402002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020402002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020403001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020403001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t020403001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t020403001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020403001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t020404001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t020404001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t020404001.1	biological_process	GO:0002218	activation of innate immune response	"Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]	OMA
NV2t020404001.1	biological_process	GO:0002230	positive regulation of defense response to virus by host	"Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]	OMA
NV2t020404001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t020404001.1	biological_process	GO:0009409	response to cold	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]	OMA
NV2t020404001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t020404001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t020404001.1	biological_process	GO:0021955	central nervous system neuron axonogenesis	"Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t020404001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t020404001.1	biological_process	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t020404001.1	biological_process	GO:0031396	regulation of protein ubiquitination	"Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t020404001.1	biological_process	GO:0032273	positive regulation of protein polymerization	"Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]	OMA
NV2t020404001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t020404001.1	biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	OMA
NV2t020404001.1	biological_process	GO:0034605	cellular response to heat	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]	OMA
NV2t020404001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t020404001.1	biological_process	GO:0045429	positive regulation of nitric oxide biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]	OMA
NV2t020404001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t020404001.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t020404001.1	biological_process	GO:0048675	axon extension	"Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl]	OMA
NV2t020404001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t020404001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	OMA
NV2t020404001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t020404001.1	biological_process	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t020404001.1	biological_process	GO:0071897	DNA biosynthetic process	"The biosynthetic process resulting in the formation of DNA." [GOC:mah]	OMA
NV2t020404001.1	biological_process	GO:0090151	establishment of protein localization to mitochondrial membrane	"The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t020404001.1	biological_process	GO:0098586	cellular response to virus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:dos]	OMA
NV2t020404001.1	biological_process	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	OMA
NV2t020404001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020404001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020404001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020404001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020404001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t020404001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t020404001.1	cellular_component	GO:0044292	dendrite terminus	"A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134]	OMA
NV2t020404001.1	cellular_component	GO:0044295	axonal growth cone	"The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954]	OMA
NV2t020404001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t020404001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t020404001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020404001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	OMA
NV2t020404001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t020404001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t020404001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t020404001.1	molecular_function	GO:0030911	TPR domain binding	"Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah]	OMA
NV2t020404001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t020404001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t020404001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	OMA
NV2t020404001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t020404001.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	OMA
NV2t020404001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t020404001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t020404001.1	molecular_function	GO:0070182	DNA polymerase binding	"Binding to a DNA polymerase." [GOC:BHF, GOC:mah]	OMA
NV2t020404001.1	molecular_function	GO:0097110	scaffold protein binding	"Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes." [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]	OMA
NV2t020404001.1	molecular_function	GO:0097718	disordered domain specific binding	"Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698]	OMA
NV2t020404001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t020404001.1	molecular_function	GO:1990782	protein tyrosine kinase binding	"Binding to protein tyrosine kinase." [PMID:25499537]	OMA
NV2t020404002.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t020404003.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t020404004.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t020404004.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t020406001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020406001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020406001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t020406001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t020408001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t020408001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t020408001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t020408001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020408001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t020408001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t020408001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t020408001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	OMA
NV2t020408001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t020408001.1	biological_process	GO:0048308	organelle inheritance	"The partitioning of organelles between daughter cells at cell division." [GOC:jid]	OMA
NV2t020408001.1	biological_process	GO:1903008	organelle disassembly	"The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie]	OMA
NV2t020408001.1	biological_process	GO:1903358	regulation of Golgi organization	"Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]	OMA
NV2t020408001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t020408001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020408001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t020408001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t020408001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t020408001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t020408001.1	molecular_function	GO:0047485	obsolete protein N-terminus binding	"OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t020409001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t020410001.1	biological_process	GO:0034975	protein folding in endoplasmic reticulum	"A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw]	OMA
NV2t020410001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t020410001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t020410001.1	molecular_function	GO:0016972	thiol oxidase activity	"Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357]	OMA
NV2t020410001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t020410001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t020410002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t020412001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020412001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t020412002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020415001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020415001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020415001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t020417001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020417001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020417001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020417001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020418001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020418001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020418001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020418001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020418001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020419001.1	cellular_component	GO:0016460	myosin II complex	"A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin]	PANTHER
NV2t020419001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020419001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020419001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t020420001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020420001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020420001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t020421001.1	biological_process	GO:0034553	mitochondrial respiratory chain complex II assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]	InterPro
NV2t020421001.1	biological_process	GO:0034553	mitochondrial respiratory chain complex II assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]	OMA
NV2t020421001.1	biological_process	GO:0034553	mitochondrial respiratory chain complex II assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]	PANTHER
NV2t020421001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020422001.1	biological_process	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	PANTHER
NV2t020422002.1	biological_process	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	PANTHER
NV2t020423001.1	biological_process	GO:0006520	amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]	InterPro
NV2t020423001.1	biological_process	GO:0006520	amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]	OMA
NV2t020423001.1	molecular_function	GO:0004067	asparaginase activity	"Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]	PANTHER
NV2t020423001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020423001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t020424001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020424001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020427001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t020428001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t020429001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020429001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t020429001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t020429001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020429001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020429001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t020430001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t020430002.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t020431001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020431002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020433001.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	PANTHER
NV2t020434001.1	molecular_function	GO:0140293	ADP-ribosylglutamate hydrolase activity	"Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose." [PMID:23481255]	PANTHER
NV2t020435001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020435001.1	molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]	OMA
NV2t020435001.1	molecular_function	GO:0018025	calmodulin-lysine N-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60]	InterPro
NV2t020437001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t020437001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t020437001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t020441001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t020442001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020442001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020442001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020442001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020443001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020443001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020443001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020443001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t020443001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t020449001.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	PANTHER
NV2t020450001.1	biological_process	GO:0015850	organic hydroxy compound transport	"The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai]	OMA
NV2t020450001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020450001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020450001.1	molecular_function	GO:0008028	monocarboxylic acid transmembrane transporter activity	"Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]	OMA
NV2t020450001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020450001.1	molecular_function	GO:1901618	organic hydroxy compound transmembrane transporter activity	"Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t020450001.1	molecular_function	GO:1901702	salt transmembrane transporter activity	"Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t020450002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020450002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020450002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020451001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020451001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020451001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t020451002.1	molecular_function	GO:0008119	thiopurine S-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]	PANTHER
NV2t020451002.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t020453001.1	molecular_function	GO:0008119	thiopurine S-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]	PANTHER
NV2t020453001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t020454001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t020454001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020458001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t020458001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t020458002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t020458002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t020458003.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t020458003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t020460001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t020460001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t020461001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020461001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t020462001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020462001.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020462001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020462001.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020462002.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020462002.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020462002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020462002.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020462003.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020462003.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020462003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020462004.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	OMA
NV2t020462004.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020462004.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020462004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020462004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020462004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020462004.1	molecular_function	GO:0004652	obsolete polynucleotide adenylyltransferase activity	"OBSOLETE. Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19]	OMA
NV2t020462004.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020462005.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020462005.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020462005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020462005.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020462006.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020462006.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020462006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020462006.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020463001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020463003.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020463003.1	biological_process	GO:0043631	obsolete RNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl]	OMA
NV2t020463003.1	molecular_function	GO:0004652	obsolete polynucleotide adenylyltransferase activity	"OBSOLETE. Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19]	OMA
NV2t020465001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020465001.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020465001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020465001.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020465002.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	OMA
NV2t020465002.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020465002.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020465002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020465002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020465002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020465002.1	molecular_function	GO:0004652	obsolete polynucleotide adenylyltransferase activity	"OBSOLETE. Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19]	OMA
NV2t020465002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020465002.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020465003.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020465003.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020465003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020465003.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020465004.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020465004.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020465004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020465004.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020465005.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020465005.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020465005.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020465005.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020465006.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020465006.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020465006.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020465006.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020465007.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020465007.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020465007.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020465007.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020465008.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020465008.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020465008.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020465008.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020467001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	PANTHER
NV2t020467001.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	InterPro
NV2t020467001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020467001.1	molecular_function	GO:1990817	poly(A) RNA polymerase activity	"Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [PMID:13965521, RHEA:11332]	InterPro
NV2t020468001.1	molecular_function	GO:0050124	N-acylneuraminate-9-phosphatase activity	"Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN]	PANTHER
NV2t020471001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t020472001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020472001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t020473001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020473001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t020473001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t020473001.1	biological_process	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	OMA
NV2t020473001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020473001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t020473001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t020473001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020473001.1	molecular_function	GO:0031386	protein tag activity	"A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]	OMA
NV2t020473001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t020473001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t020474001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020474001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t020474001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t020474001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t020474001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t020474001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t020474001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t020474001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020474001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020474001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020474002.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t020474002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t020474002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020474002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020475001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020475001.1	biological_process	GO:0030574	collagen catabolic process	"The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t020475001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	InterPro
NV2t020475001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t020475001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t020475001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020475001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020475001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020479001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t020479001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020479001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	OMA
NV2t020479001.1	molecular_function	GO:0019825	oxygen binding	"Binding to oxygen (O2)." [GOC:jl]	PANTHER
NV2t020479001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t020479001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t020479001.1	molecular_function	GO:0140104	molecular carrier activity	"Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t020481001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t020481001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t020482001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020482001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020482001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020482001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020487001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020487001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020487001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t020488001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020488001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020488001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t020488001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t020494001.1	biological_process	GO:0000301	retrograde transport, vesicle recycling within Golgi	"The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363]	OMA
NV2t020494001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020494001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t020494001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	OMA
NV2t020494001.1	cellular_component	GO:0005795	Golgi stack	"The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]	OMA
NV2t020494001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020494001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	OMA
NV2t020494001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t020494001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t020495001.1	cellular_component	GO:0031417	NatC complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471]	PANTHER
NV2t020495001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t020496001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020496001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020497001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t020500001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020500001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020500001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020503001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020503001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020503001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020503001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020503001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020503002.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020503002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020504001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t020505001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	OMA
NV2t020505001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020505001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020505001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020505001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t020505001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020505001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020506001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t020506002.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t020506003.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t020507001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020507001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020507001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020507001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020507001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020508001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020508001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t020508001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t020508002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020508002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t020509001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	PANTHER
NV2t020509001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020509001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020509001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020509002.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	PANTHER
NV2t020509002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020509002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020509003.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	PANTHER
NV2t020510001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t020510001.1	molecular_function	GO:0004806	triglyceride lipase activity	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]	OMA
NV2t020510001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510002.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510002.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510003.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510003.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510004.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510004.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510004.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510005.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510005.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510005.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510006.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510006.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510006.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510007.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510007.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510007.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510008.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510008.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510008.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510009.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510009.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510009.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020510010.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t020510010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020510010.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020510010.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t020510010.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	InterPro
NV2t020511001.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t020511001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020511001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020511002.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t020511002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t020511002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020511002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020511003.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t020511003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t020511003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020511003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020511004.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t020511004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020511004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020512001.1	biological_process	GO:0006090	pyruvate metabolic process	"The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]	OMA
NV2t020512001.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t020512001.1	biological_process	GO:0016051	carbohydrate biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t020512001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t020512001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t020512001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020512001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t020512001.1	molecular_function	GO:0004736	pyruvate carboxylase activity	"Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20844]	OMA
NV2t020512001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020512001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020512001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020512001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020512002.1	biological_process	GO:0006094	gluconeogenesis	"The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY]	InterPro
NV2t020512002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t020512002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020512002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020513001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t020513001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t020513001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t020516001.1	biological_process	GO:0070197	meiotic attachment of telomere to nuclear envelope	"The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation." [GOC:jp, GOC:pr, GOC:vw, PMID:18818742]	PANTHER
NV2t020516001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t020518001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t020518001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020518001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020518001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t020518001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t020518001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t020518001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t020524001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020525001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t020525001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t020525001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t020525001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	PANTHER
NV2t020526001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t020526001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t020526001.1	molecular_function	GO:0052745	inositol phosphate phosphatase activity	"Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]	OMA
NV2t020526001.1	molecular_function	GO:0052745	inositol phosphate phosphatase activity	"Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai]	PANTHER
NV2t020527001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t020527001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t020527001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	InterPro
NV2t020527001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t020527001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t020527001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t020527001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t020527001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020527002.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	InterPro
NV2t020527002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020528001.1	biological_process	GO:0000070	mitotic sister chromatid segregation	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]	OMA
NV2t020528001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t020528001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t020528001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t020528001.1	biological_process	GO:0033044	regulation of chromosome organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]	OMA
NV2t020528001.1	biological_process	GO:0043044	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	PANTHER
NV2t020528001.1	biological_process	GO:0043618	obsolete regulation of transcription from RNA polymerase II promoter in response to stress	"OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]	OMA
NV2t020528001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020528001.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	OMA
NV2t020528001.1	biological_process	GO:0070914	UV-damage excision repair	"A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]	OMA
NV2t020528001.1	biological_process	GO:0071479	cellular response to ionizing radiation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]	OMA
NV2t020528001.1	biological_process	GO:0090068	positive regulation of cell cycle process	"Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t020528001.1	biological_process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t020528001.1	biological_process	GO:2000105	positive regulation of DNA-templated DNA replication	"Any process that activates or increases the frequency, rate or extent of DNA-templated DNA replication." [GOC:mah]	OMA
NV2t020528001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	OMA
NV2t020528001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t020528001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t020528001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020528001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t020528001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t020528001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t020528001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t020528001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t020529001.1	molecular_function	GO:0046921	alpha-(1->6)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai]	PANTHER
NV2t020531001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t020531001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020533001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t020533001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t020533001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t020533001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t020533001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t020533001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020534001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t020534001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t020534002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t020534002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t020535001.1	biological_process	GO:0006935	chemotaxis	"The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732]	OMA
NV2t020535001.1	biological_process	GO:0007600	sensory perception	"The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph]	OMA
NV2t020535001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t020535001.1	biological_process	GO:0009798	axis specification	"The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete]	OMA
NV2t020535001.1	biological_process	GO:0032880	regulation of protein localization	"Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t020535001.1	biological_process	GO:0033043	regulation of organelle organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]	OMA
NV2t020535001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	OMA
NV2t020535001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	InterPro
NV2t020535001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t020535001.1	biological_process	GO:1990778	protein localization to cell periphery	"A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]	OMA
NV2t020535001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t020535001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t020535001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t020535001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t020535001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t020535001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t020535001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t020535001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020535001.1	molecular_function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	"Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw]	OMA
NV2t020536001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020536001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020537001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t020537001.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t020537001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t020537001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020537002.1	biological_process	GO:0031398	positive regulation of protein ubiquitination	"Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	PANTHER
NV2t020537002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020537003.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t020537004.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t020538001.1	biological_process	GO:0000244	spliceosomal tri-snRNP complex assembly	"The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384]	PANTHER
NV2t020538001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t020538002.1	biological_process	GO:0000244	spliceosomal tri-snRNP complex assembly	"The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384]	PANTHER
NV2t020539001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t020539001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020539001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t020539001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t020539002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020539002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t020541001.1	biological_process	GO:0006011	UDP-glucose metabolic process	"The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]	InterPro
NV2t020541001.1	biological_process	GO:0006011	UDP-glucose metabolic process	"The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]	OMA
NV2t020541001.1	molecular_function	GO:0070569	uridylyltransferase activity	"Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]	InterPro
NV2t020541001.1	molecular_function	GO:0070569	uridylyltransferase activity	"Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]	OMA
NV2t020541002.1	biological_process	GO:0006011	UDP-glucose metabolic process	"The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]	InterPro
NV2t020541002.1	molecular_function	GO:0070569	uridylyltransferase activity	"Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]	InterPro
NV2t020541003.1	biological_process	GO:0006011	UDP-glucose metabolic process	"The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]	InterPro
NV2t020541003.1	molecular_function	GO:0070569	uridylyltransferase activity	"Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]	InterPro
NV2t020541004.1	biological_process	GO:0006011	UDP-glucose metabolic process	"The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]	InterPro
NV2t020541004.1	molecular_function	GO:0070569	uridylyltransferase activity	"Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]	InterPro
NV2t020541005.1	biological_process	GO:0006011	UDP-glucose metabolic process	"The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]	InterPro
NV2t020541005.1	molecular_function	GO:0070569	uridylyltransferase activity	"Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]	InterPro
NV2t020542001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t020542001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t020542001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020542001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020542002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t020542002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020543001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t020543001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t020543001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020543001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020543001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t020543002.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t020543002.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t020544001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020544001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	OMA
NV2t020544001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	PANTHER
NV2t020545001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020545001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020545001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020545001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020545001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t020545001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t020546002.1	biological_process	GO:0070370	cellular heat acclimation	"Any process that increases heat tolerance of a cell in response to high temperatures." [GOC:jp]	PANTHER
NV2t020546002.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	InterPro
NV2t020547001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t020547001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t020547001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t020547001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t020551001.1	biological_process	GO:0006882	intracellular zinc ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of zinc ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t020551001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020551001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t020551001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020551001.1	molecular_function	GO:0022883	zinc efflux transmembrane transporter activity	"Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020551001.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	InterPro
NV2t020551002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020551002.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	InterPro
NV2t020552001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020552001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020552001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020552003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020552003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020554001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t020554001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t020554001.1	biological_process	GO:0035329	hippo signaling	"An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation." [PMID:17318211, PMID:18328423, PMID:36347846]	OMA
NV2t020554001.1	biological_process	GO:0042127	regulation of cell population proliferation	"Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]	OMA
NV2t020554001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020554001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	InterPro
NV2t020554001.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	OMA
NV2t020554002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020554002.1	molecular_function	GO:0060090	molecular adaptor activity	"The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]	InterPro
NV2t020555001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t020555001.1	biological_process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]	OMA
NV2t020555001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t020555001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t020555001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t020555001.1	biological_process	GO:0044085	cellular component biogenesis	"A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]	OMA
NV2t020555001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t020555001.1	biological_process	GO:0048562	embryonic organ morphogenesis	"Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t020555001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t020555001.1	biological_process	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]	OMA
NV2t020555001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t020555001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020555001.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	OMA
NV2t020555001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t020555001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t020555001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t020555001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t020555001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t020555001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t020555001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t020555001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020555001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020555001.1	molecular_function	GO:0008143	poly(A) binding	"Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl]	OMA
NV2t020556001.1	molecular_function	GO:0047820	D-glutamate cyclase activity	"Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [EC:4.2.1.48, RHEA:22360]	PANTHER
NV2t020556002.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t020556002.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t020556002.1	molecular_function	GO:0009975	cyclase activity	"Catalysis of a ring closure reaction." [ISBN:0198547684]	OMA
NV2t020556002.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t020556002.1	molecular_function	GO:0047820	D-glutamate cyclase activity	"Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [EC:4.2.1.48, RHEA:22360]	PANTHER
NV2t020556003.1	molecular_function	GO:0047820	D-glutamate cyclase activity	"Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [EC:4.2.1.48, RHEA:22360]	PANTHER
NV2t020556004.1	molecular_function	GO:0047820	D-glutamate cyclase activity	"Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [EC:4.2.1.48, RHEA:22360]	PANTHER
NV2t020557001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t020557001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t020557001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t020557002.1	molecular_function	GO:0017136	NAD-dependent histone deacetylase activity	"Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [PMID:28450737]	OMA
NV2t020557002.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t020557002.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t020557002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t020557002.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t020557002.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t020558001.1	biological_process	GO:0007051	spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]	InterPro
NV2t020558002.1	biological_process	GO:0007051	spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]	InterPro
NV2t020561001.1	biological_process	GO:0046874	quinolinate metabolic process	"The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]	PANTHER
NV2t020561001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	InterPro
NV2t020561002.1	biological_process	GO:0006164	purine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t020561002.1	biological_process	GO:0006568	tryptophan metabolic process	"The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]	OMA
NV2t020561002.1	biological_process	GO:0019359	nicotinamide nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]	OMA
NV2t020561002.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t020561002.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t020561002.1	biological_process	GO:0046874	quinolinate metabolic process	"The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]	PANTHER
NV2t020561002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020561002.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	InterPro
NV2t020561002.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t020561002.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t020565001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020565001.1	biological_process	GO:0051754	meiotic sister chromatid cohesion, centromeric	"The cell cycle process in which centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576]	PANTHER
NV2t020565001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020566001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t020566001.1	biological_process	GO:0033108	mitochondrial respiratory chain complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]	OMA
NV2t020566001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	InterPro
NV2t020566001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t020566002.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	InterPro
NV2t020568001.1	biological_process	GO:0030322	stabilization of membrane potential	"The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t020568001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t020568001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020568001.1	molecular_function	GO:0015271	outward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]	OMA
NV2t020568001.1	molecular_function	GO:0022841	potassium ion leak channel activity	"Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020569001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t020570001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t020570001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020570001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020570001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020570001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020570001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t020571001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t020571001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t020571001.1	biological_process	GO:0006268	DNA unwinding involved in DNA replication	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]	OMA
NV2t020571001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t020571001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t020571001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	InterPro
NV2t020571001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	OMA
NV2t020571001.1	cellular_component	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	OMA
NV2t020571001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t020571001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t020571001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020571001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t020571001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	OMA
NV2t020571001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t020571001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t020572001.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	OMA
NV2t020572001.1	molecular_function	GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	"Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O." [EC:4.2.1.96, RHEA:11920]	InterPro
NV2t020572001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t020573001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	PANTHER
NV2t020573001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020574001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	PANTHER
NV2t020574002.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	PANTHER
NV2t020575001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	PANTHER
NV2t020576001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020576001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020576001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020576001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020576001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020576002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020576002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020576002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020576003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020576003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020576003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020577001.1	biological_process	GO:0070192	chromosome organization involved in meiotic cell cycle	"A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah]	PANTHER
NV2t020577001.1	biological_process	GO:1990426	mitotic recombination-dependent replication fork processing	"Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart." [GOC:mah, PMID:23093942]	InterPro
NV2t020577001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t020577001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	InterPro
NV2t020577001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020577001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t020578001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t020578002.1	biological_process	GO:0006896	Golgi to vacuole transport	"The directed movement of substances from the Golgi to the vacuole." [GOC:ai]	OMA
NV2t020578002.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	InterPro
NV2t020578002.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t020578002.1	cellular_component	GO:0000938	GARP complex	"A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]	OMA
NV2t020578002.1	cellular_component	GO:0098791	Golgi apparatus subcompartment	"A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus." [GOC:dos]	OMA
NV2t020578002.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t020580001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	PANTHER
NV2t020580001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t020580001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t020580001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020580001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020580001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t020582001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t020582001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020582001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t020582001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t020582001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t020582001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t020583001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t020585001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020585001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t020585001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t020585001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t020585001.1	molecular_function	GO:0005251	delayed rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]	OMA
NV2t020586001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	PANTHER
NV2t020587001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020590001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020591001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t020593001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t020593001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	PANTHER
NV2t020593001.1	biological_process	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t020593001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020593001.1	cellular_component	GO:0045252	oxoglutarate dehydrogenase complex	"A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present." [PMID:10672230]	InterPro
NV2t020593001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t020593001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t020593001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t020593001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t020593001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t020593001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t020594001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t020594001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t020594001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020594001.1	cellular_component	GO:0034657	GID complex	"A protein complex with ubiquitin ligase activity that, in Saccharomyces cerevisiae, is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. It appears to play a broader role in cellular homeostasis and development in other species." [PMID:12686616, PMID:18508925, PMID:35682545]	OMA
NV2t020594001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020595001.1	biological_process	GO:0090307	mitotic spindle assembly	"Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw]	OMA
NV2t020595001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t020595001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t020595001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t020595001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t020595001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t020595001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t020595001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t020597001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020597001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t020597001.1	molecular_function	GO:0017168	5-oxoprolinase (ATP-hydrolyzing) activity	"Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H2O = L-glutamate + ADP + 2 H+ + phosphate." [EC:3.5.2.9, RHEA:10348]	PANTHER
NV2t020598001.1	biological_process	GO:0005513	detection of calcium ion	"The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg]	OMA
NV2t020598001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t020598001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020598001.1	molecular_function	GO:0015269	calcium-activated potassium channel activity	"Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	OMA
NV2t020598001.1	molecular_function	GO:0015459	potassium channel regulator activity	"Binds to and modulates the activity of a potassium channel." [GOC:dos, GOC:mah]	OMA
NV2t020599001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	InterPro
NV2t020599001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	OMA
NV2t020599001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	OMA
NV2t020599001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	PANTHER
NV2t020599001.1	molecular_function	GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	"Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb]	OMA
NV2t020600001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020601001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020602001.1	cellular_component	GO:0030686	90S preribosome	"A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]	PANTHER
NV2t020602002.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t020602002.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t020602002.1	cellular_component	GO:0030686	90S preribosome	"A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]	PANTHER
NV2t020603001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020603001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t020603001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t020604001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020606001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020606001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t020607001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t020607001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	PANTHER
NV2t020607001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t020610001.1	biological_process	GO:0001508	action potential	"A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]	OMA
NV2t020610001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t020610001.1	biological_process	GO:0019226	transmission of nerve impulse	"The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194]	OMA
NV2t020610001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020610001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t020610001.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t020610001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t020610001.1	molecular_function	GO:0005248	voltage-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020610002.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t020610002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020610002.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t020611001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020611001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020611002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020611002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020612001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020612001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020612001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020612001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020614001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020614001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020614001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020614002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020614002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020614002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020614003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020614003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t020614003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020614004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020614004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020614004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020616001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616002.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616003.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616004.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616005.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616005.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616006.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616006.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616007.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616007.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616008.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616008.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616008.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616009.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616009.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616009.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616010.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616010.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616010.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616011.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616011.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616011.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616012.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616012.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616012.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616013.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616013.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616013.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616014.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616014.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616014.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616015.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616015.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616015.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020616016.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t020616016.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020616016.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020618001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t020618001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020618001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020620001.1	molecular_function	GO:0004500	dopamine beta-monooxygenase activity	"Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]	InterPro
NV2t020620001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t020621001.1	molecular_function	GO:0004500	dopamine beta-monooxygenase activity	"Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]	InterPro
NV2t020621001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t020623001.1	cellular_component	GO:0005736	RNA polymerase I complex	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t020623001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t020623002.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t020623002.1	cellular_component	GO:0005736	RNA polymerase I complex	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t020623002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t020623003.1	cellular_component	GO:0005736	RNA polymerase I complex	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t020623003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t020625001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t020625001.1	cellular_component	GO:0005736	RNA polymerase I complex	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t020625001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t020625002.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t020625002.1	cellular_component	GO:0005736	RNA polymerase I complex	"RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t020625002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t020629001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t020629001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020629001.1	biological_process	GO:0035066	obsolete positive regulation of histone acetylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]	OMA
NV2t020629001.1	biological_process	GO:0035522	obsolete monoubiquitinated histone H2A deubiquitination	"OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]	OMA
NV2t020629001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020629001.1	cellular_component	GO:0070461	SAGA-type complex	"A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]	OMA
NV2t020629001.1	cellular_component	GO:0070461	SAGA-type complex	"A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]	PANTHER
NV2t020629001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t020629001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t020629001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020629002.1	cellular_component	GO:0070461	SAGA-type complex	"A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]	PANTHER
NV2t020629003.1	cellular_component	GO:0070461	SAGA-type complex	"A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]	PANTHER
NV2t020629003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020631001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020631001.1	molecular_function	GO:0047536	2-aminoadipate transaminase activity	"Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12601]	PANTHER
NV2t020631002.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t020631002.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t020631002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020631002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t020631002.1	molecular_function	GO:0047536	2-aminoadipate transaminase activity	"Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12601]	PANTHER
NV2t020631003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020631003.1	molecular_function	GO:0047536	2-aminoadipate transaminase activity	"Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12601]	PANTHER
NV2t020632001.1	biological_process	GO:0002082	regulation of oxidative phosphorylation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph]	OMA
NV2t020632001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	InterPro
NV2t020632001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	OMA
NV2t020632001.1	biological_process	GO:0097250	mitochondrial respirasome assembly	"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]	OMA
NV2t020632001.1	biological_process	GO:0097250	mitochondrial respirasome assembly	"The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701]	PANTHER
NV2t020632001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t020633002.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t020633002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020633003.1	biological_process	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation	"Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]	PANTHER
NV2t020633003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020634001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020634001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020634001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t020634001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t020634001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t020635001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t020635001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t020635001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020635001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t020635002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t020637001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020637001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t020637001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t020637001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020637001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020639001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020639001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020639001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020640001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020640001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020640001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t020640001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020640001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020641001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020641001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020641001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t020641001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020641001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020641002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020641002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020641002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t020641002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020641002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020641003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020641003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020641003.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t020641003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020641003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020641004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020641004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020641004.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t020641004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020641004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020641005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020641005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020641005.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t020641005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020641005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020644001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020644001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020645001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020645001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t020645001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t020645001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t020645002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t020648001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t020652001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t020652001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t020652001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t020653001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	InterPro
NV2t020653001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t020654001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t020654001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t020654001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t020654001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020654001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t020654001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t020654001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t020655001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t020655001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t020655001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t020655001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t020656001.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	OMA
NV2t020656001.1	biological_process	GO:0031119	tRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]	OMA
NV2t020656001.1	biological_process	GO:0031119	tRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]	PANTHER
NV2t020656001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020656001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020656001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020656001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t020656001.1	molecular_function	GO:0016866	intramolecular transferase activity	"Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t020656001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t020660001.1	biological_process	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	InterPro
NV2t020660001.1	biological_process	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	OMA
NV2t020660001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020668001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020668001.1	biological_process	GO:1901475	pyruvate transmembrane transport	"The directed movement of pyruvate across a membrane." [GOC:TermGenie]	OMA
NV2t020668001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020668001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020668001.1	molecular_function	GO:0008028	monocarboxylic acid transmembrane transporter activity	"Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]	OMA
NV2t020668001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t020672001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020673001.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	PANTHER
NV2t020673001.1	molecular_function	GO:0030145	manganese ion binding	"Binding to a manganese ion (Mn)." [GOC:ai]	InterPro
NV2t020673001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t020673002.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	OMA
NV2t020673002.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	PANTHER
NV2t020673002.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t020673002.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	OMA
NV2t020673002.1	biological_process	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t020673002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020673002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020673002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t020673002.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t020673002.1	molecular_function	GO:0030145	manganese ion binding	"Binding to a manganese ion (Mn)." [GOC:ai]	InterPro
NV2t020673002.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t020673002.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t020673003.1	biological_process	GO:0035970	peptidyl-threonine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf]	PANTHER
NV2t020673003.1	molecular_function	GO:0030145	manganese ion binding	"Binding to a manganese ion (Mn)." [GOC:ai]	InterPro
NV2t020673003.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	InterPro
NV2t020680001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t020680001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t020680002.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t020680002.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t020680003.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t020681001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t020681001.1	biological_process	GO:0007093	mitotic cell cycle checkpoint signaling	"A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle]	OMA
NV2t020681001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t020681001.1	biological_process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]	OMA
NV2t020681001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t020681001.1	biological_process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t020681001.1	cellular_component	GO:0000159	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	OMA
NV2t020681001.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	OMA
NV2t020681001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020681001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020681001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t020681001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t020681001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	InterPro
NV2t020681001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t020681001.1	molecular_function	GO:0072542	protein phosphatase activator activity	"Binds to and increases the activity of a protein phosphatase." [GOC:mah]	PANTHER
NV2t020683001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t020683001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t020685001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020685001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020685001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020685001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t020687001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020687001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020687001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t020688001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020692001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t020692001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020692001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020692001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020692001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t020692001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020692001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t020694001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020694001.1	molecular_function	GO:1990275	preribosome binding	"Binding to a preribosome." [GOC:di, PMID:22735702]	PANTHER
NV2t020694002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020694002.1	molecular_function	GO:1990275	preribosome binding	"Binding to a preribosome." [GOC:di, PMID:22735702]	PANTHER
NV2t020696001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020696001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t020696001.1	biological_process	GO:1990575	mitochondrial L-ornithine transmembrane transport	"The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9237680]	PANTHER
NV2t020697001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t020697001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t020698001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t020698001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020698001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t020698001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t020698003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020698004.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020698005.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020698006.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020700001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t020700001.1	biological_process	GO:0043436	oxoacid metabolic process	"The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid]	OMA
NV2t020700001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t020700001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020700001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t020700001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t020701001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t020701001.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	InterPro
NV2t020701001.1	molecular_function	GO:0052717	tRNA-specific adenosine-34 deaminase activity	"Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule." [PMID:17875641, RHEA:43168]	PANTHER
NV2t020703001.1	biological_process	GO:0006405	RNA export from nucleus	"The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t020703001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	OMA
NV2t020703001.1	biological_process	GO:0035195	miRNA-mediated post-transcriptional gene silencing	"A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants." [GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604]	OMA
NV2t020703001.1	biological_process	GO:1900370	positive regulation of post-transcriptional gene silencing by RNA	"Any process that activates or increases the frequency, rate or extent of post-transcriptional gene silencing by RNA." [GOC:kmv, GOC:TermGenie, PMID:22412382]	OMA
NV2t020703001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020703001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020703001.1	cellular_component	GO:0016442	RISC complex	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]	OMA
NV2t020703001.1	cellular_component	GO:0031074	nucleocytoplasmic transport complex	"Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]	OMA
NV2t020703001.1	cellular_component	GO:0042565	RNA nuclear export complex	"A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123]	PANTHER
NV2t020703001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t020703001.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t020703001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t020703001.1	molecular_function	GO:0070883	pre-miRNA binding	"Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]	OMA
NV2t020703001.1	molecular_function	GO:1905172	RISC complex binding	"Binding to a RISC complex." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24882364]	OMA
NV2t020704001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020704001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t020704001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t020704001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t020704001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020704001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t020709001.1	biological_process	GO:0001952	regulation of cell-matrix adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]	OMA
NV2t020709001.1	biological_process	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t020709001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t020709001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t020709001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t020709001.1	biological_process	GO:0022408	negative regulation of cell-cell adhesion	"Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t020709001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t020709001.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	OMA
NV2t020709001.1	biological_process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t020709001.1	biological_process	GO:0043409	negative regulation of MAPK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]	PANTHER
NV2t020709001.1	biological_process	GO:0045931	positive regulation of mitotic cell cycle	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t020709001.1	biological_process	GO:0046329	negative regulation of JNK cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]	OMA
NV2t020709001.1	biological_process	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	OMA
NV2t020709001.1	biological_process	GO:0050922	negative regulation of chemotaxis	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]	OMA
NV2t020709001.1	biological_process	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t020709001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t020709001.1	biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]	OMA
NV2t020709001.1	biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]	OMA
NV2t020709001.1	biological_process	GO:1901888	regulation of cell junction assembly	"Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t020709001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020709001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020709001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020709001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t020709001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	OMA
NV2t020709001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	InterPro
NV2t020709001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t020709001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t020709001.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	OMA
NV2t020709001.1	molecular_function	GO:0033549	MAP kinase phosphatase activity	"Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316]	OMA
NV2t020713001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020713002.1	biological_process	GO:0006509	membrane protein ectodomain proteolysis	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]	OMA
NV2t020713002.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t020713002.1	biological_process	GO:0007220	Notch receptor processing	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]	OMA
NV2t020713002.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t020713002.1	biological_process	GO:0007610	behavior	"The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]	OMA
NV2t020713002.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t020713002.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t020713002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t020713002.1	biological_process	GO:0042987	amyloid precursor protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]	OMA
NV2t020713002.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t020713002.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t020713002.1	biological_process	GO:0050435	amyloid-beta metabolic process	"The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai]	OMA
NV2t020713002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020713002.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t020713002.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t020713002.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t020713002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t020713002.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t020713002.1	cellular_component	GO:0030018	Z disc	"Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]	OMA
NV2t020713002.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t020713002.1	cellular_component	GO:0031594	neuromuscular junction	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]	OMA
NV2t020713002.1	cellular_component	GO:0035253	ciliary rootlet	"A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]	OMA
NV2t020713002.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t020713002.1	cellular_component	GO:0043198	dendritic shaft	"Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln]	OMA
NV2t020713002.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t020713002.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t020713002.1	cellular_component	GO:0070765	gamma-secretase complex	"A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein." [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437]	OMA
NV2t020713002.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	InterPro
NV2t020713002.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t020713003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020713004.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	InterPro
NV2t020713005.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	InterPro
NV2t020713006.1	molecular_function	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]	InterPro
NV2t020714002.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t020714002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020714002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020714003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020718001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020720001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t020720001.1	biological_process	GO:0006436	tryptophanyl-tRNA aminoacylation	"The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t020720001.1	biological_process	GO:0006436	tryptophanyl-tRNA aminoacylation	"The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	OMA
NV2t020720001.1	biological_process	GO:0006436	tryptophanyl-tRNA aminoacylation	"The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t020720001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t020720001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t020720001.1	biological_process	GO:0022603	regulation of anatomical structure morphogenesis	"Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]	OMA
NV2t020720001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t020720001.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t020720001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020720001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020720001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t020720001.1	molecular_function	GO:0004830	tryptophan-tRNA ligase activity	"Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]	OMA
NV2t020720001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020720001.1	molecular_function	GO:0019210	kinase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah]	OMA
NV2t020720001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t020720001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t020720001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t020721001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t020721001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020721002.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t020721002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020721003.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t020721003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020721004.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t020721004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020721006.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t020721006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020721007.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t020721007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020722001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t020722001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020722002.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	InterPro
NV2t020722002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020722003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020725001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t020725001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020725001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t020725001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t020725001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t020725002.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020725003.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020728001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020735001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020735002.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	OMA
NV2t020735002.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t020735002.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020735002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t020735002.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t020735003.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020735004.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020735005.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020735006.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t020736001.1	biological_process	GO:0010466	negative regulation of peptidase activity	"Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t020736001.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t020736001.1	biological_process	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t020736001.1	biological_process	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t020736001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t020736001.1	biological_process	GO:0090085	regulation of protein deubiquitination	"Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t020736001.1	biological_process	GO:1903094	negative regulation of protein K48-linked deubiquitination	"Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21097510]	PANTHER
NV2t020736001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020736001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t020736001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t020736001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t020736001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020736001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t020736001.1	molecular_function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein." [GOC:al, PMID:20739285]	OMA
NV2t020736001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t020736001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t020737001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020737001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020737002.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t020737002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020737002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020737002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020739001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	OMA
NV2t020739001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t020739001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t020739001.1	molecular_function	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]	OMA
NV2t020739002.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	PANTHER
NV2t020740001.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t020740001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020740001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020740002.1	biological_process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	"Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	PANTHER
NV2t020740002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020740002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t020740002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020741001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020741001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t020741002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020741002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t020744001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t020744002.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t020744003.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t020744004.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t020746001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020746001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020751001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t020751001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t020751001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t020751001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t020751001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t020751001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020751002.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t020751002.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020752001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020752001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t020752002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020752002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020752002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t020752002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t020753001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020753001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020754001.1	biological_process	GO:0044528	regulation of mitochondrial mRNA stability	"Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs." [GOC:al, GOC:jl]	PANTHER
NV2t020755001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	OMA
NV2t020755001.1	biological_process	GO:0070897	transcription preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]	InterPro
NV2t020755001.1	biological_process	GO:0070897	transcription preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]	OMA
NV2t020755001.1	cellular_component	GO:0000126	transcription factor TFIIIB complex	"A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012]	OMA
NV2t020755001.1	cellular_component	GO:0097550	transcription preinitiation complex	"A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016]	PANTHER
NV2t020755001.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t020755001.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	OMA
NV2t020755001.1	molecular_function	GO:0140223	general transcription initiation factor activity	"A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018]	OMA
NV2t020755002.1	cellular_component	GO:0097550	transcription preinitiation complex	"A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016]	PANTHER
NV2t020755002.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t020757001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020757001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t020759001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	OMA
NV2t020759001.1	biological_process	GO:0046855	obsolete inositol phosphate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732]	OMA
NV2t020759001.1	molecular_function	GO:0008252	nucleotidase activity	"Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [RHEA:22140]	OMA
NV2t020759001.1	molecular_function	GO:0008441	3'(2'),5'-bisphosphate nucleotidase activity	"Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7]	PANTHER
NV2t020761001.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t020761001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020764001.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t020764001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020764001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t020764002.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t020764002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020765001.1	biological_process	GO:0033345	asparagine catabolic process via L-aspartate	"The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]	PANTHER
NV2t020765001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t020771001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	PANTHER
NV2t020772001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t020772001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t020772001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t020772001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t020772001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020772001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t020772001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t020773001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020773001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020774001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t020774001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t020777001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	InterPro
NV2t020777001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t020777001.1	biological_process	GO:0033499	galactose catabolic process via UDP-galactose	"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821]	PANTHER
NV2t020777001.1	molecular_function	GO:0016853	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	InterPro
NV2t020777001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	OMA
NV2t020777001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t020777001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t020778001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020778001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020778001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020778001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020778002.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020778002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020778002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020778002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020778003.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t020778003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020778003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020778003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020780001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t020780001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t020780001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	PANTHER
NV2t020780001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020781001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t020781001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t020788001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t020788001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t020788001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t020790001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020790001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t020790001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t020790001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020790001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020791001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020791001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020791001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020792001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t020792001.1	biological_process	GO:0007276	gamete generation	"The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]	OMA
NV2t020792001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t020792001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t020792001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t020792001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t020792001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t020792001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t020795001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t020797001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t020797001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t020797001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t020797001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t020797001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t020797002.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t020798001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020798001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t020798001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t020798001.1	biological_process	GO:0010637	negative regulation of mitochondrial fusion	"Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]	OMA
NV2t020798001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t020798001.1	biological_process	GO:1903852	positive regulation of cristae formation	"Any process that activates or increases the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012]	OMA
NV2t020798001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t020798001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t020798001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020799001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020799001.1	molecular_function	GO:0008568	microtubule severing ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [PMID:10910766]	InterPro
NV2t020799001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t020799001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t020799001.1	molecular_function	GO:0140603	obsolete ATP hydrolysis activity	"OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [GOC:curators]	PANTHER
NV2t020800001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	PANTHER
NV2t020800001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020800001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t020800001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020800001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020800001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020800001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020800001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t020801001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020801001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020801001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t020801002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020801003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020802001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t020802001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t020802001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t020802001.1	cellular_component	GO:0000178	exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t020802001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t020802001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t020802001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020804001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t020804001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t020804001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020804001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020805001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t020805001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t020805001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t020806001.1	biological_process	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	OMA
NV2t020806001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t020806001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t020806001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t020809001.1	biological_process	GO:0044878	mitotic cytokinesis checkpoint signaling	"A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed." [GOC:jl, GOC:mtg_cell_cycle, PMID:17538026]	PANTHER
NV2t020810001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t020810001.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	InterPro
NV2t020810001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t020810001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t020812001.1	biological_process	GO:0031167	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	PANTHER
NV2t020813001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t020814001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t020814001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t020814001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t020814001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020814001.1	molecular_function	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	"Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]	OMA
NV2t020815001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t020815001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t020817001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020817002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020819001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t020819001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t020819001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	OMA
NV2t020819001.1	molecular_function	GO:0004896	cytokine receptor activity	"Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]	OMA
NV2t020819001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020819001.1	molecular_function	GO:0019955	cytokine binding	"Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]	OMA
NV2t020821001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t020821001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t020821002.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t020822001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t020822001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020822001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t020826001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t020826001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t020826001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t020826001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t020827001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t020827001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t020828001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020828001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t020828001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t020828001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t020829001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020829001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020830001.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t020830001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t020830001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t020830001.1	molecular_function	GO:0016229	steroid dehydrogenase activity	"Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]	OMA
NV2t020830001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020833001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t020833001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	PANTHER
NV2t020833001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t020833001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t020833001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020834001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t020837001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t020838001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	InterPro
NV2t020838001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t020838001.1	molecular_function	GO:0004602	glutathione peroxidase activity	"Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9, PMID:36771108]	OMA
NV2t020839001.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	PANTHER
NV2t020839001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t020842001.1	biological_process	GO:0007224	smoothened signaling pathway	"The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15057936, PMID:15205520]	InterPro
NV2t020842001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	PANTHER
NV2t020844001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t020844001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t020844001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	InterPro
NV2t020844001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t020844001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t020844001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	PANTHER
NV2t020844001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t020844001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020844001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t020844001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t020845001.1	biological_process	GO:0006084	acetyl-CoA metabolic process	"The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]	OMA
NV2t020845001.1	biological_process	GO:0006695	cholesterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]	InterPro
NV2t020845001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t020845001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t020845001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	OMA
NV2t020845001.1	biological_process	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	"The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]	PANTHER
NV2t020845001.1	biological_process	GO:1902653	secondary alcohol biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t020845001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020845001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020845001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t020845001.1	molecular_function	GO:0016776	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	OMA
NV2t020846001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020846001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020846001.1	molecular_function	GO:0008235	metalloexopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]	OMA
NV2t020846001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t020846001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t020846001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020846002.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t020847001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t020847002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t020850001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t020850002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t020850002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t020852001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t020852001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020852001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t020853001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020853001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t020854001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t020854001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t020854001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t020854001.1	biological_process	GO:0006627	protein processing involved in protein targeting to mitochondrion	"The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]	PANTHER
NV2t020854001.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	OMA
NV2t020854001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020854001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	InterPro
NV2t020854001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t020854001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t020855001.1	biological_process	GO:0006525	arginine metabolic process	"The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]	OMA
NV2t020855001.1	biological_process	GO:0009065	glutamine family amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t020855001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020855001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020855001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t020855001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t020855001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t020856001.1	biological_process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	"A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]	OMA
NV2t020856001.1	biological_process	GO:0000291	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]	OMA
NV2t020856001.1	biological_process	GO:0006304	DNA modification	"The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]	OMA
NV2t020856001.1	biological_process	GO:0016072	rRNA metabolic process	"The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]	OMA
NV2t020856001.1	biological_process	GO:0031126	sno(s)RNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea." [GOC:krc, GOC:mah, PMID:17284456]	OMA
NV2t020856001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t020856001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t020856001.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t020856001.1	biological_process	GO:0071027	nuclear RNA surveillance	"A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474]	OMA
NV2t020856001.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t020856001.1	cellular_component	GO:0000176	nuclear exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t020856001.1	cellular_component	GO:0000791	euchromatin	"A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]	OMA
NV2t020856001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t020856001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020857001.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	OMA
NV2t020857001.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	PANTHER
NV2t020857001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t020857001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t020857001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t020857001.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t020857001.1	molecular_function	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t020857002.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	PANTHER
NV2t020857002.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t020857003.1	biological_process	GO:0009083	branched-chain amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]	PANTHER
NV2t020857003.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t020858001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t020858001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	PANTHER
NV2t020858001.1	molecular_function	GO:0016840	carbon-nitrogen lyase activity	"Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]	OMA
NV2t020858001.1	molecular_function	GO:0016844	strictosidine synthase activity	"Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15013]	InterPro
NV2t020859001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t020859002.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t020859002.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t020859002.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t020859002.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t020859002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t020859002.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t020859002.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t020859002.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t020859003.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	InterPro
NV2t020859003.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t020861001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020861001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020863001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t020863001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t020863001.1	biological_process	GO:0043487	regulation of RNA stability	"Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl]	OMA
NV2t020863001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020863001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t020863001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t020863001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t020863001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020863001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020864001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	InterPro
NV2t020864001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t020864001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020864001.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	PANTHER
NV2t020864002.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	InterPro
NV2t020864002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020864002.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	PANTHER
NV2t020864003.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	InterPro
NV2t020864003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020864003.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	PANTHER
NV2t020864004.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	InterPro
NV2t020864004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020864004.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	PANTHER
NV2t020864005.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	InterPro
NV2t020864005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020864005.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	PANTHER
NV2t020864006.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	InterPro
NV2t020864006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020864006.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	PANTHER
NV2t020865001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020865001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t020865001.1	biological_process	GO:0045786	negative regulation of cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t020865001.1	biological_process	GO:0045786	negative regulation of cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t020865001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t020865001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t020865001.1	cellular_component	GO:0035097	histone methyltransferase complex	"A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]	OMA
NV2t020865001.1	molecular_function	GO:0000403	Y-form DNA binding	"Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730]	OMA
NV2t020865001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t020865001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t020866001.1	biological_process	GO:0002183	cytoplasmic translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]	OMA
NV2t020866001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t020866001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t020866001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t020866001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020866001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t020866001.1	molecular_function	GO:0005092	GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]	OMA
NV2t020866001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020866001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t020866001.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t020866002.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t020866002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020866002.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t020866003.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t020866003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020866003.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t020866004.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t020866004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020866004.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t020866005.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t020866005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020866005.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t020867001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t020867001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t020867001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t020869001.1	biological_process	GO:0097039	protein linear polyubiquitination	"A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein." [GOC:jsg, GOC:sp, PMID:21455173, PMID:21455180, PMID:21455181]	PANTHER
NV2t020869001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020871001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t020871001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020871001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t020871001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t020871001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t020871001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t020871001.1	molecular_function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	"Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease]	OMA
NV2t020871001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020871001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t020872001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t020874001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t020874002.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t020874003.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	PANTHER
NV2t020876001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t020876001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t020876001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t020876001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t020876001.1	molecular_function	GO:0004879	nuclear receptor activity	"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]	OMA
NV2t020876001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020876001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020876001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t020876002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t020876003.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t020876003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020876003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t020878001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t020878001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t020878001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020878001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020879001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020879001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t020879001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	PANTHER
NV2t020879001.1	biological_process	GO:1990809	endoplasmic reticulum tubular network membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane." [PMID:20434336]	OMA
NV2t020879001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t020879001.1	cellular_component	GO:0071782	endoplasmic reticulum tubular network	"A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	OMA
NV2t020879001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t020879001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020879001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020879001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t020879002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	PANTHER
NV2t020879002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020880001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t020880001.1	biological_process	GO:0030100	regulation of endocytosis	"Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]	OMA
NV2t020880001.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	InterPro
NV2t020880001.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	OMA
NV2t020880001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020880001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t020880001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t020880001.1	molecular_function	GO:0003925	G protein activity	"A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]	OMA
NV2t020880001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020880001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020880002.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	InterPro
NV2t020880002.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t020880002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020880003.1	biological_process	GO:0032482	Rab protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rab subfamily relays a signal." [GOC:mah]	InterPro
NV2t020880003.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t020880003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020881001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020883001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t020883001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020884001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t020884001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020884001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t020885001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	OMA
NV2t020885001.1	biological_process	GO:0006469	negative regulation of protein kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t020885001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020885001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020885001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t020885001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t020885001.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	PANTHER
NV2t020885001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t020885001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t020885001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t020885001.1	molecular_function	GO:0000993	RNA polymerase II complex binding	"Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH]	OMA
NV2t020885001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t020885001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t020885002.1	cellular_component	GO:0072669	tRNA-splicing ligase complex	"A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021]	PANTHER
NV2t020890001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020890001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	PANTHER
NV2t020893001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020895001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	InterPro
NV2t020895001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t020896001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t020896001.1	biological_process	GO:0001711	endodermal cell fate commitment	"The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437]	OMA
NV2t020896001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t020896001.1	biological_process	GO:0006378	obsolete mRNA polyadenylation	"OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732]	OMA
NV2t020896001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t020896001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t020896001.1	biological_process	GO:0031062	obsolete positive regulation of histone methylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]	OMA
NV2t020896001.1	biological_process	GO:0031440	regulation of mRNA 3'-end processing	"Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	OMA
NV2t020896001.1	biological_process	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	OMA
NV2t020896001.1	biological_process	GO:0045596	negative regulation of cell differentiation	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t020896001.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	OMA
NV2t020896001.1	biological_process	GO:1902808	positive regulation of cell cycle G1/S phase transition	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie]	OMA
NV2t020896001.1	biological_process	GO:1903313	positive regulation of mRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t020896001.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t020896001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020896001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020896001.1	cellular_component	GO:0016593	Cdc73/Paf1 complex	"A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]	InterPro
NV2t020896001.1	cellular_component	GO:0016593	Cdc73/Paf1 complex	"A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]	OMA
NV2t020896001.1	molecular_function	GO:0000993	RNA polymerase II complex binding	"Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH]	OMA
NV2t020896001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t020897001.1	biological_process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	"Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators, GOC:pr]	InterPro
NV2t020897001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	PANTHER
NV2t020898001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020898001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t020898001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t020898001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t020898001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t020905001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t020905001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	OMA
NV2t020905001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t020905001.1	cellular_component	GO:0000930	gamma-tubulin complex	"A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]	OMA
NV2t020905001.1	cellular_component	GO:0031083	BLOC-1 complex	"A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]	OMA
NV2t020905001.1	cellular_component	GO:0099078	BORC complex	"A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167]	PANTHER
NV2t020905001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	OMA
NV2t020906001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020906003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t020907001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020907001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t020907001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t020910001.1	cellular_component	GO:0030176	obsolete integral component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t020910002.1	cellular_component	GO:0030176	obsolete integral component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t020910003.1	cellular_component	GO:0030176	obsolete integral component of endoplasmic reticulum membrane	"OBSOLETE. The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t020911001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020912001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t020912001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	PANTHER
NV2t020912002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t020912002.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	PANTHER
NV2t020912003.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t020912003.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t020912003.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t020912003.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t020912003.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	PANTHER
NV2t020912003.1	molecular_function	GO:0016881	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	OMA
NV2t020912003.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t020913001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t020913001.1	molecular_function	GO:0004500	dopamine beta-monooxygenase activity	"Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]	InterPro
NV2t020913001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t020913001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t020913001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t020913002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t020913002.1	molecular_function	GO:0004500	dopamine beta-monooxygenase activity	"Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1, RHEA:19117]	InterPro
NV2t020913002.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t020914001.1	biological_process	GO:0034312	diol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah]	OMA
NV2t020914001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t020914001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	PANTHER
NV2t020914001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t020914001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t020914001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t020914001.1	molecular_function	GO:0004758	serine C-palmitoyltransferase activity	"Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA." [EC:2.3.1.50, RHEA:14761]	OMA
NV2t020914001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t020914001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020914001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t020915001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020915001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020915001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t020915001.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t020915001.1	molecular_function	GO:0008327	methyl-CpG binding	"Binding to a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232]	OMA
NV2t020916001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t020916001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t020916001.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t020916001.1	molecular_function	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t020916001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t020916001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t020916001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t020916001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t020916001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t020916001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t020916001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t020916001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t020916002.1	molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]	InterPro
NV2t020916002.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	InterPro
NV2t020921001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t020921001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t020921001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t020921001.1	molecular_function	GO:0008171	O-methyltransferase activity	"Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t020924001.1	biological_process	GO:0000070	mitotic sister chromatid segregation	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]	OMA
NV2t020924001.1	biological_process	GO:0007094	mitotic spindle assembly checkpoint signaling	"A mitotic cell cycle checkpoint that delays mitotic sister chromatid separation and consequently the mitotic metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. Spindle assembly checkpoint signaling begins with the activated Mph family kinase, and results in the inhibition of the Anaphase Promoting Complex and its activator Sleepy/Cdc20 by the mitotic checkpoint complex (MCC)." [GOC:mtg_cell_cycle, PMID:12360190]	OMA
NV2t020924001.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	OMA
NV2t020924001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	OMA
NV2t020924001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t020924001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020924001.1	cellular_component	GO:0005828	kinetochore microtubule	"Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]	OMA
NV2t020924001.1	cellular_component	GO:1990423	RZZ complex	"A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]	OMA
NV2t020924001.1	cellular_component	GO:1990423	RZZ complex	"A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]	PANTHER
NV2t020924001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020924001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t020925001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020925001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t020927001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t020927001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t020927001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t020928001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t020928001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020928001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t020928001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	OMA
NV2t020928001.1	biological_process	GO:0035194	regulatory ncRNA-mediated post-transcriptional gene silencing	"A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation." [GOC:ems, PMID:11201747, PMID:11713190, PMID:15020054, PMID:15066275, PMID:18771919, PMID:32885814, PMID:33184244]	OMA
NV2t020928001.1	biological_process	GO:0046833	positive regulation of RNA export from nucleus	"Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]	OMA
NV2t020928001.1	biological_process	GO:1902369	negative regulation of RNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]	OMA
NV2t020928001.1	biological_process	GO:1902369	negative regulation of RNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457]	PANTHER
NV2t020928001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t020928001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t020928001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020930001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020930001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t020930001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020933001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t020933001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t020933001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020933001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t020935001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t020935001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	PANTHER
NV2t020935001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t020935001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020935001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020935001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020936001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	PANTHER
NV2t020936001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020937001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t020937001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t020937001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t020937001.1	biological_process	GO:0008360	regulation of cell shape	"Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t020937001.1	biological_process	GO:0030865	cortical cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t020937001.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	OMA
NV2t020937001.1	biological_process	GO:0043652	engulfment of apoptotic cell	"The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]	PANTHER
NV2t020937001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t020937001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t020937001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t020937001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t020937001.1	cellular_component	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t020937001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t020937001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t020937001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t020937001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t020939001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t020939001.1	biological_process	GO:0000423	mitophagy	"The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367]	OMA
NV2t020939001.1	biological_process	GO:0001933	negative regulation of protein phosphorylation	"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t020939001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t020939001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t020939001.1	biological_process	GO:0008333	endosome to lysosome transport	"The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]	OMA
NV2t020939001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t020939001.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	OMA
NV2t020939001.1	biological_process	GO:0016241	regulation of macroautophagy	"Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]	OMA
NV2t020939001.1	biological_process	GO:0033674	positive regulation of kinase activity	"Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]	OMA
NV2t020939001.1	biological_process	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [GOC:al, GOC:vw]	OMA
NV2t020939001.1	biological_process	GO:0043551	obsolete regulation of phosphatidylinositol 3-kinase activity	"OBSOLETE. Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf]	OMA
NV2t020939001.1	biological_process	GO:0045022	early endosome to late endosome transport	"The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194, PMID:29980602]	OMA
NV2t020939001.1	biological_process	GO:0045834	positive regulation of lipid metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]	OMA
NV2t020939001.1	biological_process	GO:0097352	autophagosome maturation	"Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293]	OMA
NV2t020939001.1	biological_process	GO:0098780	response to mitochondrial depolarisation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria." [GOC:dos]	OMA
NV2t020939001.1	biological_process	GO:0140056	organelle localization by membrane tethering	"The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684]	OMA
NV2t020939001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t020939001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t020939001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t020939001.1	cellular_component	GO:0031312	extrinsic component of organelle membrane	"The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah]	OMA
NV2t020939001.1	cellular_component	GO:0035032	phosphatidylinositol 3-kinase complex, class III	"A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069]	OMA
NV2t020939001.1	cellular_component	GO:0044233	mitochondria-associated endoplasmic reticulum membrane contact site	"A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109]	OMA
NV2t020939001.1	cellular_component	GO:0097632	extrinsic component of phagophore assembly site membrane	"The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf]	PANTHER
NV2t020939001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t020939001.1	cellular_component	GO:1990462	omegasome	"Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites." [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649]	OMA
NV2t020939001.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	OMA
NV2t020940001.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	PANTHER
NV2t020941001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020941001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020941001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020944001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t020947001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t020947001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	InterPro
NV2t020947001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	PANTHER
NV2t020948001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t020948001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t020948001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t020950001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t020950001.1	biological_process	GO:0031054	pre-miRNA processing	"A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]	InterPro
NV2t020950001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	PANTHER
NV2t020950001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t020950001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	InterPro
NV2t020951001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t020951001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t020952001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020952001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t020953001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020953001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t020953001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t020953001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t020953001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t020954001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t020954001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t020954001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t020954001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t020956001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t020956001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t020956001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t020959001.1	biological_process	GO:0019853	L-ascorbic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:ma, ISBN:0198547684]	PANTHER
NV2t020959001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t020959001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	InterPro
NV2t020959001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t020959001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t020959002.1	biological_process	GO:0019853	L-ascorbic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:ma, ISBN:0198547684]	PANTHER
NV2t020960001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t020960001.1	biological_process	GO:0007229	integrin-mediated signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t020960001.1	biological_process	GO:0010631	epithelial cell migration	"The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t020960001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t020960001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t020960001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t020960001.1	biological_process	GO:0050673	epithelial cell proliferation	"The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]	OMA
NV2t020960001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t020960001.1	biological_process	GO:0051049	regulation of transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t020960001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t020960001.1	biological_process	GO:0090162	establishment of epithelial cell polarity	"The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t020960001.1	biological_process	GO:0090303	positive regulation of wound healing	"Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF]	OMA
NV2t020960001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t020960001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t020960001.1	cellular_component	GO:0030055	cell-substrate junction	"A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002]	PANTHER
NV2t020960001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t020960001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t020960001.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t020962001.1	biological_process	GO:0043647	inositol phosphate metabolic process	"The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:jl]	OMA
NV2t020962001.1	biological_process	GO:0052746	obsolete inositol phosphorylation	"OBSOLETE. The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ISBN:0198506732]	PANTHER
NV2t020962001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t020962001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020962001.1	molecular_function	GO:0051765	inositol tetrakisphosphate kinase activity	"Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai]	OMA
NV2t020962001.1	molecular_function	GO:0051766	inositol trisphosphate kinase activity	"Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP + H+." [GOC:ai]	OMA
NV2t020962001.1	molecular_function	GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+." [RHEA:13253]	InterPro
NV2t020966001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t020971001.1	biological_process	GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	"The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]	InterPro
NV2t020971001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t020971001.1	molecular_function	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	"Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t020972001.1	biological_process	GO:0006165	obsolete nucleoside diphosphate phosphorylation	"OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	OMA
NV2t020972001.1	biological_process	GO:0009142	nucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t020972001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t020972001.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	OMA
NV2t020972001.1	molecular_function	GO:0004127	cytidylate kinase activity	"Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14]	OMA
NV2t020972001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t020972001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t020972001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t020972001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t020973001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t020973001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	InterPro
NV2t020973001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	OMA
NV2t020973001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t020973001.1	biological_process	GO:0045089	positive regulation of innate immune response	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]	OMA
NV2t020973001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t020973001.1	cellular_component	GO:0005666	RNA polymerase III complex	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t020973001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t020973001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t020973002.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	InterPro
NV2t020973002.1	cellular_component	GO:0005666	RNA polymerase III complex	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t020980001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t020980001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t020981001.1	biological_process	GO:0009190	cyclic nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t020981001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t020981001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t020981001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020981002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t020981002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020981003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t020981003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t020982001.1	cellular_component	GO:0045239	tricarboxylic acid cycle heteromeric enzyme complex	"Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]	InterPro
NV2t020982001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t020982001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t020983001.1	biological_process	GO:0032781	positive regulation of ATP-dependent activity	"Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah]	PANTHER
NV2t020983001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t020984001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020984001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t020984002.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t020985001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t020985001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t020985001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t020985001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t020985001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t020985001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t020985001.1	molecular_function	GO:0070008	serine-type exopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]	InterPro
NV2t020990001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t020991001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t020992001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t020992001.1	biological_process	GO:0032787	monocarboxylic acid metabolic process	"The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]	OMA
NV2t020992001.1	molecular_function	GO:0008410	CoA-transferase activity	"Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t020992001.1	molecular_function	GO:0008410	CoA-transferase activity	"Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t020992001.1	molecular_function	GO:0008775	acetate CoA-transferase activity	"Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8]	InterPro
NV2t020992001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t020997001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t020997001.1	molecular_function	GO:0070008	serine-type exopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]	InterPro
NV2t020998001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t020998001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t020998001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t020998001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	InterPro
NV2t020998001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t020998001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t020999001.1	biological_process	GO:0032781	positive regulation of ATP-dependent activity	"Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah]	OMA
NV2t020999001.1	biological_process	GO:0032781	positive regulation of ATP-dependent activity	"Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah]	PANTHER
NV2t020999001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t020999001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t020999001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021000001.1	biological_process	GO:0000820	regulation of glutamine family amino acid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators]	OMA
NV2t021000001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t021000001.1	biological_process	GO:0006108	malate metabolic process	"The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t021000001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t021000001.1	biological_process	GO:0031061	obsolete negative regulation of histone methylation	"OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]	OMA
NV2t021000001.1	biological_process	GO:0043604	amide biosynthetic process	"The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]	OMA
NV2t021000001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t021000001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t021000001.1	biological_process	GO:2000781	positive regulation of double-strand break repair	"Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t021000001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021000001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t021000001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021000001.1	cellular_component	GO:0045239	tricarboxylic acid cycle heteromeric enzyme complex	"Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]	InterPro
NV2t021000001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t021000001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t021000001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t021000001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t021001001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021007001.1	biological_process	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	InterPro
NV2t021007001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t021007002.1	biological_process	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	InterPro
NV2t021007002.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t021007003.1	biological_process	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	InterPro
NV2t021007003.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t021007004.1	biological_process	GO:0030705	cytoskeleton-dependent intracellular transport	"The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]	InterPro
NV2t021007004.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t021011001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t021014001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t021014001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t021014001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021014001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t021016001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t021016001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021016001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t021017001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021017001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t021017001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t021017001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t021017001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021017001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t021017001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021017001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021018001.1	biological_process	GO:0052746	obsolete inositol phosphorylation	"OBSOLETE. The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ISBN:0198506732]	PANTHER
NV2t021018001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021018001.1	molecular_function	GO:0035299	inositol pentakisphosphate 2-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+." [RHEA:20313]	InterPro
NV2t021018001.1	molecular_function	GO:0035299	inositol pentakisphosphate 2-kinase activity	"Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+." [RHEA:20313]	OMA
NV2t021019001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t021023001.1	biological_process	GO:0006491	N-glycan processing	"The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]	OMA
NV2t021023001.1	biological_process	GO:0006622	protein targeting to lysosome	"The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators]	OMA
NV2t021023001.1	biological_process	GO:0007040	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	OMA
NV2t021023001.1	biological_process	GO:0046835	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t021023001.1	biological_process	GO:0046835	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	PANTHER
NV2t021023001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t021023001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t021023001.1	cellular_component	GO:0061695	transferase complex, transferring phosphorus-containing groups	"A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph]	OMA
NV2t021023001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021023001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021023001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021023001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t021023002.1	biological_process	GO:0046835	carbohydrate phosphorylation	"The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732]	PANTHER
NV2t021023002.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021024001.1	biological_process	GO:0036503	ERAD pathway	"The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]	PANTHER
NV2t021024001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021024002.1	biological_process	GO:0036503	ERAD pathway	"The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857]	PANTHER
NV2t021024002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021025001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t021025001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t021025001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021025001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t021025001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t021025001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	PANTHER
NV2t021025001.1	molecular_function	GO:0042379	chemokine receptor binding	"Binding to a chemokine receptor." [GOC:ai]	OMA
NV2t021026001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t021028001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021028001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	InterPro
NV2t021028001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t021028001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	PANTHER
NV2t021028001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021028001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t021031001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021031001.1	molecular_function	GO:0051184	obsolete cofactor transmembrane transporter activity	"OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]	PANTHER
NV2t021032003.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t021032003.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	PANTHER
NV2t021032003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021032003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t021032004.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	PANTHER
NV2t021032004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021034001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	InterPro
NV2t021036001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021036001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021036001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021036001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021038001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t021038001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t021038001.1	molecular_function	GO:0004462	lactoylglutathione lyase activity	"Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19069]	OMA
NV2t021038001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021038001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021038002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021039001.1	biological_process	GO:0006829	zinc ion transport	"The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t021039001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021039003.1	biological_process	GO:0006829	zinc ion transport	"The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t021039003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021039004.1	biological_process	GO:0006829	zinc ion transport	"The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t021039004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021039004.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t021039004.1	molecular_function	GO:0005385	zinc ion transmembrane transporter activity	"Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t021041001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t021041001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021043001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t021043001.1	biological_process	GO:0048870	cell motility	"Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]	PANTHER
NV2t021043001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t021044001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t021044001.1	biological_process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]	OMA
NV2t021044001.1	biological_process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]	PANTHER
NV2t021044001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t021044001.1	cellular_component	GO:0045277	respiratory chain complex IV	"A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]	InterPro
NV2t021044001.1	cellular_component	GO:0045277	respiratory chain complex IV	"A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]	OMA
NV2t021045001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t021048001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t021050001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021050001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t021050001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t021052001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t021052001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t021052002.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t021052002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t021053001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t021053001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t021065001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021066001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021067001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t021067001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021069001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021069001.1	molecular_function	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	"Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]	PANTHER
NV2t021072001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021072001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021072001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021072001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t021072001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t021072001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021074001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021074002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021081001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021083001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021085001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t021085001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021085002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t021085002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021087001.1	biological_process	GO:0000423	mitophagy	"The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367]	OMA
NV2t021087001.1	biological_process	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	OMA
NV2t021087001.1	biological_process	GO:0007007	inner mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t021087001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t021087001.1	biological_process	GO:0032048	cardiolipin metabolic process	"The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah]	OMA
NV2t021087001.1	cellular_component	GO:0031966	mitochondrial membrane	"Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829]	OMA
NV2t021087001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t021087001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021087001.1	molecular_function	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity	"Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]	PANTHER
NV2t021090001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021092001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t021092001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021092001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021092002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021093001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t021093001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	InterPro
NV2t021093001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t021093001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021093001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t021093001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t021095001.1	cellular_component	GO:0035102	PRC1 complex	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]	PANTHER
NV2t021096001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	PANTHER
NV2t021097001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021097001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t021097001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t021097001.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	OMA
NV2t021097001.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	PANTHER
NV2t021097001.1	molecular_function	GO:0042826	histone deacetylase binding	"Binding to histone deacetylase." [GOC:jl]	OMA
NV2t021097002.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	PANTHER
NV2t021099001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t021099001.1	biological_process	GO:0006325	chromatin organization	"The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA." [PMID:20404130]	OMA
NV2t021099001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t021099001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t021099001.1	biological_process	GO:0007084	mitotic nuclear membrane reassembly	"The mitotic cell cycle process involving ESCRTIII that results in reformation of the nuclear envelope after mitotic nuclear division. In organisms undergoing closed mitosis this involves resealing or 'repair' of the nuclear envelope in the nuclear bridge." [PMID:26040712, PMID:28242692, PMID:32109380, PMID:32848252]	OMA
NV2t021099001.1	biological_process	GO:0030261	chromosome condensation	"The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]	OMA
NV2t021099001.1	biological_process	GO:0051348	negative regulation of transferase activity	"Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]	OMA
NV2t021099001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t021099001.1	cellular_component	GO:0000793	condensed chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]	OMA
NV2t021099001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t021099001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t021099001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021099001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021099001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t021099001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t021100001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t021100001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t021100001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t021100001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t021102001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021103001.1	biological_process	GO:0010951	negative regulation of endopeptidase activity	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t021103001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	InterPro
NV2t021103001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t021103001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t021104001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021105001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021105001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t021105002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021105002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t021105002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t021105002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t021105002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021105002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021105002.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	OMA
NV2t021105002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t021105002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021105003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021105003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t021107001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021108001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021108001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021108001.1	molecular_function	GO:0043014	alpha-tubulin binding	"Binding to the microtubule constituent protein alpha-tubulin." [GOC:jl]	InterPro
NV2t021108001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t021109001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t021109001.1	biological_process	GO:0010955	negative regulation of protein processing	"Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t021109001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t021109001.1	biological_process	GO:0045746	negative regulation of Notch signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t021109001.1	biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708]	OMA
NV2t021109001.1	biological_process	GO:1901575	organic substance catabolic process	"The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie]	OMA
NV2t021109001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t021109001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021109001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	OMA
NV2t021109001.1	molecular_function	GO:0016842	amidine-lyase activity	"Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]	OMA
NV2t021109001.1	molecular_function	GO:0061928	glutathione specific gamma-glutamylcyclotransferase activity	"Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine." [PMID:23070364, PMID:27913623]	InterPro
NV2t021111001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t021111001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021112001.1	biological_process	GO:0009158	ribonucleoside monophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t021112001.1	biological_process	GO:0046128	purine ribonucleoside metabolic process	"The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]	OMA
NV2t021112001.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t021112001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t021112001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021112001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021112001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t021112001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	InterPro
NV2t021112001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	OMA
NV2t021112001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	PANTHER
NV2t021113001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021114001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t021114001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t021114001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t021114001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021115001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t021115001.1	biological_process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	"Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb]	OMA
NV2t021115001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t021115001.1	cellular_component	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex	"A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]	InterPro
NV2t021115001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t021115001.1	molecular_function	GO:0000400	four-way junction DNA binding	"Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]	OMA
NV2t021115001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t021115001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t021115001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021115001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t021115001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021115001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t021115001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t021116001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t021116001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t021119001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t021119001.1	biological_process	GO:0016050	vesicle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]	OMA
NV2t021119001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t021119001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t021119001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	OMA
NV2t021119001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t021120001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t021120001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021121001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021121001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t021123001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021124001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	InterPro
NV2t021124001.1	molecular_function	GO:0034511	U3 snoRNA binding	"Binding to a U3 small nucleolar RNA." [GOC:mah]	PANTHER
NV2t021125001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t021126001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t021126001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021127001.1	biological_process	GO:0006082	organic acid metabolic process	"The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]	OMA
NV2t021127001.1	biological_process	GO:0006805	xenobiotic metabolic process	"The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc]	OMA
NV2t021127001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021127001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t021127001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t021127001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	OMA
NV2t021127001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t021127001.1	molecular_function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t021127001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t021127001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t021127001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t021131001.1	biological_process	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]	OMA
NV2t021131001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021131001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t021131001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t021131001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t021131001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t021131001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t021131001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t021131001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	PANTHER
NV2t021132001.1	biological_process	GO:0032417	positive regulation of sodium:proton antiporter activity	"Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah]	PANTHER
NV2t021132001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021135001.1	biological_process	GO:0006829	zinc ion transport	"The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t021135001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021135001.1	molecular_function	GO:0008324	monoatomic cation transmembrane transporter activity	"Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021137001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021137001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t021137001.1	cellular_component	GO:0035102	PRC1 complex	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]	OMA
NV2t021137001.1	cellular_component	GO:0035102	PRC1 complex	"A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979]	PANTHER
NV2t021137001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t021137001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t021141001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t021144001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t021144001.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	InterPro
NV2t021144002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t021144002.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	InterPro
NV2t021144002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021144002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t021144003.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t021144003.1	biological_process	GO:0006402	mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	InterPro
NV2t021145001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t021145001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t021145001.1	molecular_function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t021145001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t021145001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t021146001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t021146001.1	biological_process	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	OMA
NV2t021146001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t021146001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t021146001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021146001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t021146001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021146001.1	cellular_component	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	OMA
NV2t021146001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021146001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t021146001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t021146001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t021146001.1	molecular_function	GO:0045182	translation regulator activity	"Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]	OMA
NV2t021147001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t021147001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021147001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021147001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021147001.1	molecular_function	GO:0016885	ligase activity, forming carbon-carbon bonds	"Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-, GOC:jl, GOC:mah]	OMA
NV2t021147001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021147001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t021148001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021148002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021148003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021149001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021151001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021151002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021151003.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t021151003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021153001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021158001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158005.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021158006.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021158007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158009.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021158009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158010.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t021158010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158011.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t021158011.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021158011.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t021158011.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t021158011.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t021158011.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t021158011.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t021158011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158014.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021158015.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021158016.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021158018.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021158019.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021160001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021160001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021160002.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021160002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	OMA
NV2t021160002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021160002.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t021160002.1	molecular_function	GO:0050839	cell adhesion molecule binding	"Binding to a cell adhesion molecule." [GOC:ai]	OMA
NV2t021160003.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021166001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	PANTHER
NV2t021166001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t021166001.1	cellular_component	GO:0005762	mitochondrial large ribosomal subunit	"The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]	InterPro
NV2t021166001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t021166001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t021166001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t021168001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021168001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t021168001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021170004.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t021170005.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t021170006.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t021170007.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t021171001.1	biological_process	GO:0099041	vesicle tethering to Golgi	"The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion." [PMID:27243008]	PANTHER
NV2t021172001.1	cellular_component	GO:0031415	NatA complex	"A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471]	PANTHER
NV2t021172001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t021172001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t021173001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021173001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t021173002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021173002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t021173003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021173003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	PANTHER
NV2t021173003.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t021173003.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t021173003.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t021173003.1	biological_process	GO:0032874	positive regulation of stress-activated MAPK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]	OMA
NV2t021173003.1	biological_process	GO:0034614	cellular response to reactive oxygen species	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]	OMA
NV2t021173003.1	biological_process	GO:0042542	response to hydrogen peroxide	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]	OMA
NV2t021173003.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t021173003.1	biological_process	GO:0048308	organelle inheritance	"The partitioning of organelles between daughter cells at cell division." [GOC:jid]	OMA
NV2t021173003.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t021173003.1	biological_process	GO:0051683	establishment of Golgi localization	"The directed movement of the Golgi to a specific location." [GOC:ai]	OMA
NV2t021173003.1	biological_process	GO:0097193	intrinsic apoptotic signaling pathway	"The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]	OMA
NV2t021173003.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t021173003.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t021173003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021173003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021173003.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t021174001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021174001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t021183001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021183001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021183001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021184001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	InterPro
NV2t021184001.1	biological_process	GO:0071712	obsolete ER-associated misfolded protein catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [PMID:14607247, PMID:19520858]	PANTHER
NV2t021186001.1	biological_process	GO:0010165	response to X-ray	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray]	OMA
NV2t021186001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021186001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t021186001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021186001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021189001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	PANTHER
NV2t021189001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021191001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	PANTHER
NV2t021191001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021192001.1	biological_process	GO:0015701	bicarbonate transport	"The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t021192001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t021192001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t021192001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021192001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t021192001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t021192001.1	molecular_function	GO:0005452	solute:inorganic anion antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)." [GOC:mah]	OMA
NV2t021192001.1	molecular_function	GO:0008509	monoatomic anion transmembrane transporter activity	"Enables the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021193001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t021193001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t021193002.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t021193002.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t021193003.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t021193003.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t021193004.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t021193004.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t021193005.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t021193005.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t021196001.1	biological_process	GO:0001522	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule." [GOC:hjd, GOC:mah]	OMA
NV2t021196001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021196001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t021196001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	PANTHER
NV2t021196001.1	molecular_function	GO:0016866	intramolecular transferase activity	"Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t021198001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t021198001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	PANTHER
NV2t021198002.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t021198002.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	PANTHER
NV2t021198003.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t021198003.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	PANTHER
NV2t021202001.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	InterPro
NV2t021204001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t021204001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t021204001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t021204001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021205001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021205001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	InterPro
NV2t021205001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t021205001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021205001.1	molecular_function	GO:0004402	histone acetyltransferase activity	"Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]	OMA
NV2t021205001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021205002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021205003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021206001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	InterPro
NV2t021206002.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	InterPro
NV2t021211001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021211001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021214001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021215001.1	biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021216001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021217001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t021217001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021217001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021217001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021217001.1	molecular_function	GO:0016885	ligase activity, forming carbon-carbon bonds	"Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-, GOC:jl, GOC:mah]	OMA
NV2t021217001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021217001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t021217002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021217002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021217002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021218001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t021218001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021218001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t021219001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t021219001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t021219001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t021219001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t021219001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t021219001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t021219001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t021219002.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t021219002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t021219002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t021220001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021222001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	InterPro
NV2t021222001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	OMA
NV2t021222001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021222001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t021223001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	InterPro
NV2t021223001.1	biological_process	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	"Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]	OMA
NV2t021223001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021223001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t021225001.1	biological_process	GO:0098535	de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	"Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation." [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997]	PANTHER
NV2t021225002.1	biological_process	GO:0098535	de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	"Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation." [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997]	PANTHER
NV2t021225003.1	biological_process	GO:0098535	de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	"Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation." [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997]	PANTHER
NV2t021225004.1	biological_process	GO:0098535	de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	"Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation." [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997]	PANTHER
NV2t021229001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021229001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t021229001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t021229001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t021229001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t021229001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021229001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t021229001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021230001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021230001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t021230001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t021230001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t021230001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021230001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t021230001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021236001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t021236001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t021236001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t021237001.1	biological_process	GO:0043486	obsolete histone exchange	"OBSOLETE. The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]	PANTHER
NV2t021238001.1	cellular_component	GO:0034663	endoplasmic reticulum chaperone complex	"A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]	PANTHER
NV2t021238001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021238001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t021238001.1	molecular_function	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	OMA
NV2t021238001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t021239001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021239001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t021239001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t021239001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t021239001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t021239002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t021239002.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t021239003.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t021239003.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t021239004.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t021239004.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t021240001.1	biological_process	GO:0035493	SNARE complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468]	PANTHER
NV2t021240001.1	cellular_component	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	"A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]	InterPro
NV2t021240002.1	biological_process	GO:0035493	SNARE complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468]	PANTHER
NV2t021240003.1	biological_process	GO:0035493	SNARE complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468]	PANTHER
NV2t021240003.1	cellular_component	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	"A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251]	InterPro
NV2t021241001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021241001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t021241001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021241002.1	biological_process	GO:0007276	gamete generation	"The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]	OMA
NV2t021241002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t021241002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021241002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021241002.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t021241002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021241002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t021241002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021241002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021242001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t021242001.1	cellular_component	GO:0016272	prefoldin complex	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]	OMA
NV2t021242001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	PANTHER
NV2t021242001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t021242001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t021243001.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	InterPro
NV2t021243001.1	cellular_component	GO:0070552	BRISC complex	"A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]	PANTHER
NV2t021243001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021244001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t021244001.1	molecular_function	GO:0008251	tRNA-specific adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah]	InterPro
NV2t021244001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021244001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021244001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t021244001.1	molecular_function	GO:0052717	tRNA-specific adenosine-34 deaminase activity	"Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule." [PMID:17875641, RHEA:43168]	PANTHER
NV2t021245001.1	biological_process	GO:0006525	arginine metabolic process	"The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]	OMA
NV2t021245001.1	biological_process	GO:0009084	glutamine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t021245001.1	biological_process	GO:0042450	arginine biosynthetic process via ornithine	"The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl]	InterPro
NV2t021245001.1	biological_process	GO:0042450	arginine biosynthetic process via ornithine	"The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl]	PANTHER
NV2t021245001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021245001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t021245001.1	molecular_function	GO:0016842	amidine-lyase activity	"Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]	OMA
NV2t021252001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021252001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021252002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021252002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021252003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021254001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	OMA
NV2t021254001.1	biological_process	GO:0071569	protein ufmylation	"Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]	InterPro
NV2t021254001.1	biological_process	GO:1990592	protein K69-linked ufmylation	"A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498]	PANTHER
NV2t021254001.1	molecular_function	GO:0061650	ubiquitin-like protein conjugating enzyme activity	"Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph]	OMA
NV2t021256001.1	biological_process	GO:0006940	regulation of smooth muscle contraction	"Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]	OMA
NV2t021256001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t021256001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t021256001.1	biological_process	GO:0035296	regulation of tube diameter	"Any process that modulates the diameter of a tube." [GOC:bf]	OMA
NV2t021256001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t021256001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021256001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021256001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t021257001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021257001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t021257002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021257002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t021257002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t021257003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021257003.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t021257004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021257004.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t021260001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t021261001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021261001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t021262001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021262002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021263001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021265001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021265001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t021265001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021266001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021266001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t021266001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t021266001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021266002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021266002.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t021266002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t021268001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t021268001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021268001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021269001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t021269001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t021269001.1	cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]	OMA
NV2t021269001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t021269001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t021269001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t021269002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t021269002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t021270001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021271003.1	biological_process	GO:0007594	puparial adhesion	"The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma]	OMA
NV2t021271003.1	biological_process	GO:0042381	hemolymph coagulation	"Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]	OMA
NV2t021271003.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t021271003.1	cellular_component	GO:0062129	chitin-based extracellular matrix	"Any constituent part of a chitin-based noncellular, hardened, or membranous extracellular matrix secreted from the apical surface of an epithelial sheet." [PMID:23955854]	OMA
NV2t021271003.1	cellular_component	GO:0062130	adhesive extracellular matrix	"A extracellular matrix which attaches an organism to a substrate." [GOC:dph, GOC:ha, PMID:825230]	OMA
NV2t021273001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021274001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021274001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021274001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021274001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021274001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021280001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t021282001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t021282001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t021282001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021284001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t021291001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t021291001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021291001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t021291001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t021291001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021297001.1	molecular_function	GO:0008460	dTDP-glucose 4,6-dehydratase activity	"Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O." [EC:4.2.1.46, RHEA:17221]	PANTHER
NV2t021298001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t021298001.1	biological_process	GO:0019236	response to pheromone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]	InterPro
NV2t021298001.1	biological_process	GO:0019236	response to pheromone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]	OMA
NV2t021299001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021299001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021299001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021299001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021299002.1	biological_process	GO:0008016	regulation of heart contraction	"Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t021299002.1	biological_process	GO:0030003	intracellular monoatomic cation homeostasis	"A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:mah]	OMA
NV2t021299002.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t021299002.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t021299002.1	biological_process	GO:0098659	inorganic cation import across plasma membrane	"The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t021299002.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t021299002.1	biological_process	GO:0140115	export across plasma membrane	"The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg]	OMA
NV2t021299002.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	OMA
NV2t021299002.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021299002.1	cellular_component	GO:0005890	sodium:potassium-exchanging ATPase complex	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]	OMA
NV2t021299002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021299002.1	cellular_component	GO:0042383	sarcolemma	"The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]	OMA
NV2t021299002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021299002.1	molecular_function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:7.2.2.13]	OMA
NV2t021299002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021299002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021299002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t021299003.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021299003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021299003.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021299003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021300001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021300001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t021300001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021300001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021300001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021300001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t021300001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t021301001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t021301001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021301001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021301001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021301001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t021301001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t021302001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021302001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021302002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021302002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021302002.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021303001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021303001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021307001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t021308001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t021308001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021308001.1	molecular_function	GO:0043139	5'-3' DNA helicase activity	"Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [EC:5.6.2.3, GOC:jl]	PANTHER
NV2t021309001.1	biological_process	GO:0010587	miRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]	PANTHER
NV2t021309001.1	biological_process	GO:0035194	regulatory ncRNA-mediated post-transcriptional gene silencing	"A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation." [GOC:ems, PMID:11201747, PMID:11713190, PMID:15020054, PMID:15066275, PMID:18771919, PMID:32885814, PMID:33184244]	OMA
NV2t021309001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021309001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	OMA
NV2t021309001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021309001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t021309001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	OMA
NV2t021309001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021309001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	OMA
NV2t021309001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t021310001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021312001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021313001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t021313001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021314001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t021315001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t021315001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	OMA
NV2t021315001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t021315001.1	molecular_function	GO:0043139	5'-3' DNA helicase activity	"Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [EC:5.6.2.3, GOC:jl]	PANTHER
NV2t021316001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t021316001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021317001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t021317001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t021317001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021318001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021318001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t021321001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021321001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t021321001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	OMA
NV2t021321001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021321001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	OMA
NV2t021321001.1	molecular_function	GO:0030374	nuclear receptor coactivator activity	"A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb]	OMA
NV2t021321001.1	molecular_function	GO:0035198	miRNA binding	"Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]	PANTHER
NV2t021322001.1	biological_process	GO:0010587	miRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]	PANTHER
NV2t021322001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021323001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021324001.1	biological_process	GO:0045494	photoreceptor cell maintenance	"Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl]	InterPro
NV2t021328001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t021328001.1	biological_process	GO:0007414	axonal defasciculation	"Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X]	OMA
NV2t021328001.1	biological_process	GO:0007629	flight behavior	"The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907]	OMA
NV2t021328001.1	biological_process	GO:0007638	mechanosensory behavior	"Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]	OMA
NV2t021328001.1	biological_process	GO:0008039	synaptic target recognition	"The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]	OMA
NV2t021328001.1	biological_process	GO:0016199	axon midline choice point recognition	"The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]	OMA
NV2t021328001.1	biological_process	GO:0030537	larval behavior	"Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099]	OMA
NV2t021328001.1	biological_process	GO:0045467	R7 cell development	"The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]	OMA
NV2t021328001.1	biological_process	GO:0048814	regulation of dendrite morphogenesis	"Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]	OMA
NV2t021328001.1	biological_process	GO:0070593	dendrite self-avoidance	"The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]	OMA
NV2t021328001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021328001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t021328001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021328001.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	OMA
NV2t021329001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t021329001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021329001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t021329001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021330001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t021330001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t021330001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021330002.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t021330002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021330003.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t021330003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021331001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t021331001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021331001.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	OMA
NV2t021331001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021331002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021332001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021333001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021333001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021333001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021337001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t021337002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t021337003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t021338001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t021338001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021338001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021338001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021338001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t021338001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t021338002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t021338002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021338002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021338002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t021340001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t021340001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t021341001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021341002.1	biological_process	GO:0000266	mitochondrial fission	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]	InterPro
NV2t021341002.1	biological_process	GO:0000266	mitochondrial fission	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]	OMA
NV2t021341002.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t021341002.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t021341002.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	OMA
NV2t021341002.1	biological_process	GO:0007204	positive regulation of cytosolic calcium ion concentration	"Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai]	OMA
NV2t021341002.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	OMA
NV2t021341002.1	biological_process	GO:0019722	calcium-mediated signaling	"Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling]	OMA
NV2t021341002.1	biological_process	GO:0032368	regulation of lipid transport	"Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t021341002.1	biological_process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	"Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021341002.1	biological_process	GO:0032890	regulation of organic acid transport	"Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t021341002.1	biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t021341002.1	biological_process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	"The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:mtg_apoptosis, GOC:rk, PMID:12867994]	PANTHER
NV2t021341002.1	biological_process	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	"Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	OMA
NV2t021341002.1	biological_process	GO:0045936	negative regulation of phosphate metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	OMA
NV2t021341002.1	biological_process	GO:0051051	negative regulation of transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t021341002.1	biological_process	GO:0051560	mitochondrial calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]	OMA
NV2t021341002.1	biological_process	GO:0070584	obsolete mitochondrion morphogenesis	"OBSOLETE. The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah]	OMA
NV2t021341002.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t021341002.1	biological_process	GO:0090316	positive regulation of intracellular protein transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t021341002.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	OMA
NV2t021341002.1	biological_process	GO:1903578	regulation of ATP metabolic process	"Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849]	OMA
NV2t021341002.1	biological_process	GO:1905477	positive regulation of protein localization to membrane	"Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	OMA
NV2t021341002.1	biological_process	GO:1905953	negative regulation of lipid localization	"Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]	OMA
NV2t021341002.1	biological_process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t021341002.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t021341002.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t021341002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t021341002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021341002.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t021341003.1	biological_process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	"The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:mtg_apoptosis, GOC:rk, PMID:12867994]	PANTHER
NV2t021341003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021342001.1	biological_process	GO:0006826	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t021342001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t021342001.1	biological_process	GO:0051651	maintenance of location in cell	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]	OMA
NV2t021342001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021342001.1	molecular_function	GO:0004322	ferroxidase activity	"Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [RHEA:11148]	OMA
NV2t021342001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t021342001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t021342001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t021343001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t021343001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t021343001.1	biological_process	GO:0007229	integrin-mediated signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t021343001.1	biological_process	GO:0007599	hemostasis	"The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732]	OMA
NV2t021343001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t021343001.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	OMA
NV2t021343001.1	biological_process	GO:0033627	cell adhesion mediated by integrin	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]	PANTHER
NV2t021343001.1	biological_process	GO:0034109	homotypic cell-cell adhesion	"The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add]	OMA
NV2t021343001.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t021343001.1	biological_process	GO:0050817	coagulation	"The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732]	OMA
NV2t021343001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t021343001.1	cellular_component	GO:0008305	integrin complex	"A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]	OMA
NV2t021343001.1	molecular_function	GO:0005178	integrin binding	"Binding to an integrin." [GOC:ceb]	OMA
NV2t021346001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t021346001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021346001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021348001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021349001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t021349001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t021349001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021349001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021351001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021351001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021351001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t021351002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021351002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021351002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t021351003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021351003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021351003.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t021351004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021351004.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021351004.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t021352001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t021352001.1	biological_process	GO:0032367	intracellular cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah]	InterPro
NV2t021352001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t021352001.1	molecular_function	GO:0032934	sterol binding	"Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah]	PANTHER
NV2t021353001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021353001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021353003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021355002.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t021356001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	PANTHER
NV2t021356001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t021358001.1	biological_process	GO:1902410	mitotic cytokinetic process	"Any cytokinetic process that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t021360001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t021360001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021360001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t021360001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t021360001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021360002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t021360002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021360002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t021369001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t021369001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021369001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021369001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021370001.1	biological_process	GO:0007288	sperm axoneme assembly	"The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t021370001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021370001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	OMA
NV2t021372001.1	biological_process	GO:0003008	system process	"A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]	OMA
NV2t021372001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t021372001.1	biological_process	GO:0009628	response to abiotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb]	OMA
NV2t021372001.1	biological_process	GO:0030003	intracellular monoatomic cation homeostasis	"A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:mah]	OMA
NV2t021372001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	OMA
NV2t021372001.1	biological_process	GO:0042391	regulation of membrane potential	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]	OMA
NV2t021372001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	OMA
NV2t021372001.1	biological_process	GO:0098659	inorganic cation import across plasma membrane	"The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t021372001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t021372001.1	biological_process	GO:0140115	export across plasma membrane	"The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg]	OMA
NV2t021372001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021372001.1	cellular_component	GO:0005890	sodium:potassium-exchanging ATPase complex	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]	OMA
NV2t021372001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t021372001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t021372002.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t021372002.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021373001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t021373001.1	molecular_function	GO:0015645	fatty acid ligase activity	"Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [GOC:cjk, GOC:mah]	OMA
NV2t021373001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t021375001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t021384001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	OMA
NV2t021384001.1	biological_process	GO:1904668	positive regulation of ubiquitin protein ligase activity	"Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882]	OMA
NV2t021384001.1	biological_process	GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	"Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876]	OMA
NV2t021384001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t021384001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021384001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t021384001.1	molecular_function	GO:0010997	anaphase-promoting complex binding	"Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t021384001.1	molecular_function	GO:1990757	ubiquitin ligase activator activity	"Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242]	PANTHER
NV2t021385001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021385001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t021385001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021385001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021387001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021387001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	PANTHER
NV2t021387001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021387002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021387002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	PANTHER
NV2t021387002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021387003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021387003.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	PANTHER
NV2t021387003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021387003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t021387004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021387004.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	PANTHER
NV2t021387004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021387005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021387005.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	PANTHER
NV2t021387005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021387005.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t021387006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021387006.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	PANTHER
NV2t021387006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021387006.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t021387007.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021387007.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	PANTHER
NV2t021387007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021387007.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t021388001.1	biological_process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	"Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb]	PANTHER
NV2t021388001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021388001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021389001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t021389001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t021389001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t021389001.1	biological_process	GO:0033014	tetrapyrrole biosynthetic process	"The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	InterPro
NV2t021389001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t021389001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t021389001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t021389001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t021389001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t021389001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021389001.1	molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	"Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t021390001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t021390001.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t021390001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	OMA
NV2t021390001.1	molecular_function	GO:0015078	proton transmembrane transporter activity	"Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai]	OMA
NV2t021393001.1	biological_process	GO:0000070	mitotic sister chromatid segregation	"The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl]	OMA
NV2t021393001.1	cellular_component	GO:0000775	chromosome, centromeric region	"The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr]	OMA
NV2t021393001.1	cellular_component	GO:0032133	chromosome passenger complex	"A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]	OMA
NV2t021393001.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	OMA
NV2t021393001.1	cellular_component	GO:0051233	spindle midzone	"The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]	PANTHER
NV2t021394001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t021394001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021394001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021394002.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t021394002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021401001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t021401001.1	biological_process	GO:0007042	lysosomal lumen acidification	"Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid]	OMA
NV2t021401001.1	biological_process	GO:0007417	central nervous system development	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]	OMA
NV2t021401001.1	biological_process	GO:0008015	blood circulation	"The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]	OMA
NV2t021401001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t021401001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t021401001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t021401001.1	biological_process	GO:0016486	peptide hormone processing	"The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah]	OMA
NV2t021401001.1	biological_process	GO:0035295	tube development	"The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]	OMA
NV2t021401001.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	OMA
NV2t021401001.1	biological_process	GO:0048069	eye pigmentation	"Establishment of a pattern of pigment in the eye of an organism." [GOC:jid]	OMA
NV2t021401001.1	biological_process	GO:0050886	endocrine process	"The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544]	OMA
NV2t021401001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t021401001.1	biological_process	GO:0060323	head morphogenesis	"The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph]	OMA
NV2t021401001.1	biological_process	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	OMA
NV2t021401001.1	biological_process	GO:0071695	anatomical structure maturation	"A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah]	OMA
NV2t021401001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	OMA
NV2t021401001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t021401001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021401001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t021401001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t021401001.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t021401001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t021401001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	OMA
NV2t021402001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t021402001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	PANTHER
NV2t021403001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t021403001.1	biological_process	GO:0031334	positive regulation of protein-containing complex assembly	"Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t021403001.1	biological_process	GO:0045898	regulation of RNA polymerase II transcription preinitiation complex assembly	"Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]	OMA
NV2t021403001.1	biological_process	GO:0045899	positive regulation of RNA polymerase II transcription preinitiation complex assembly	"Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]	PANTHER
NV2t021403001.1	biological_process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	"Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]	OMA
NV2t021403001.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t021403001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021403001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021403001.1	cellular_component	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t021403001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021403001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021403001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t021403001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t021404001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t021404001.1	biological_process	GO:0008366	axon ensheathment	"Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]	OMA
NV2t021404001.1	biological_process	GO:0030148	sphingolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t021404001.1	biological_process	GO:0034312	diol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah]	OMA
NV2t021404001.1	biological_process	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	OMA
NV2t021404001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t021404001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t021404001.1	biological_process	GO:0071602	phytosphingosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol." [GOC:mah]	PANTHER
NV2t021404001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021404001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t021404001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021404001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021404001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	InterPro
NV2t021404001.1	molecular_function	GO:0017040	N-acylsphingosine amidohydrolase activity	"Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]	OMA
NV2t021409001.1	cellular_component	GO:0005581	collagen trimer	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]	InterPro
NV2t021409001.1	cellular_component	GO:0005581	collagen trimer	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]	OMA
NV2t021409001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021409001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t021411001.1	cellular_component	GO:0005581	collagen trimer	"A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]	InterPro
NV2t021411001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021413001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021413001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t021413001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021413001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021415001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t021415001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t021415001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t021417001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t021417001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t021417001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021417001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t021417001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t021419001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021419001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021419001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021423001.1	biological_process	GO:0055080	monoatomic cation homeostasis	"Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t021423002.1	biological_process	GO:0055080	monoatomic cation homeostasis	"Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t021423003.1	biological_process	GO:0055080	monoatomic cation homeostasis	"Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:jid, GOC:mah]	PANTHER
NV2t021427001.1	biological_process	GO:0006820	monoatomic anion transport	"The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom." [GOC:ai]	OMA
NV2t021427001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021427001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021427001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t021427001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021427001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t021428001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021428001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t021429001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t021429001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t021429001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t021429001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t021429001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t021429001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t021432001.1	biological_process	GO:0009308	amine metabolic process	"The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]	OMA
NV2t021432001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t021432001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t021432001.1	molecular_function	GO:0048038	quinone binding	"Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]	InterPro
NV2t021433001.1	molecular_function	GO:0048038	quinone binding	"Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]	InterPro
NV2t021438001.1	molecular_function	GO:0048038	quinone binding	"Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]	InterPro
NV2t021449001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021449001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t021450001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021450001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021450001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021450002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021450002.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t021450002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021450002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021450002.1	molecular_function	GO:0016885	ligase activity, forming carbon-carbon bonds	"Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-, GOC:jl, GOC:mah]	OMA
NV2t021450002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021450002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t021452001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t021452001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t021452001.1	biological_process	GO:0042797	tRNA transcription by RNA polymerase III	"The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t021452001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t021452001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t021452001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021452001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021453001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	PANTHER
NV2t021453001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t021454001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t021454001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021454001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t021454001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t021454001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t021454001.1	molecular_function	GO:0043843	ADP-specific glucokinase activity	"Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147]	PANTHER
NV2t021455001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021455002.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t021455002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021456001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t021456001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021456001.1	molecular_function	GO:0017110	nucleoside diphosphate phosphatase activity	"Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate." [EC:3.6.1.6]	OMA
NV2t021456001.1	molecular_function	GO:0044716	8-oxo-GDP phosphatase activity	"Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate." [GOC:pde, PMID:22556419, RHEA:62356]	PANTHER
NV2t021456002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021456002.1	molecular_function	GO:0044716	8-oxo-GDP phosphatase activity	"Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate." [GOC:pde, PMID:22556419, RHEA:62356]	PANTHER
NV2t021459001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t021459001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t021459001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t021459001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t021459001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t021459001.1	biological_process	GO:2000431	regulation of cytokinesis, actomyosin contractile ring assembly	"Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]	InterPro
NV2t021459001.1	biological_process	GO:2000431	regulation of cytokinesis, actomyosin contractile ring assembly	"Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]	OMA
NV2t021459001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021459001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t021459001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t021459001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t021459001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t021459002.1	biological_process	GO:2000431	regulation of cytokinesis, actomyosin contractile ring assembly	"Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]	InterPro
NV2t021461001.1	biological_process	GO:0003007	heart morphogenesis	"The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]	OMA
NV2t021461001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t021461001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t021461001.1	biological_process	GO:0022607	cellular component assembly	"The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]	OMA
NV2t021461001.1	biological_process	GO:0035239	tube morphogenesis	"The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]	OMA
NV2t021461001.1	biological_process	GO:0035329	hippo signaling	"An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation." [PMID:17318211, PMID:18328423, PMID:36347846]	OMA
NV2t021461001.1	biological_process	GO:0042246	tissue regeneration	"The regrowth of lost or destroyed tissues." [GOC:curators]	OMA
NV2t021461001.1	biological_process	GO:0042592	homeostatic process	"Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]	OMA
NV2t021461001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t021461001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021461001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021461001.1	biological_process	GO:0046620	regulation of organ growth	"Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]	OMA
NV2t021461001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t021461001.1	biological_process	GO:0048565	digestive tract development	"The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators]	OMA
NV2t021461001.1	biological_process	GO:0048568	embryonic organ development	"Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t021461001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t021461001.1	biological_process	GO:0060429	epithelium development	"The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]	OMA
NV2t021461001.1	biological_process	GO:0071495	cellular response to endogenous stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]	OMA
NV2t021461001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021461001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021461001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t021461001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t021461001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021461001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021461002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021461003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021461003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021461004.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021461005.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021463001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t021464001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t021466001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t021467001.1	biological_process	GO:0000338	protein deneddylation	"The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]	OMA
NV2t021467001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021467001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	InterPro
NV2t021467001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	OMA
NV2t021467001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t021467001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021467001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021467001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t021470001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021470001.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	PANTHER
NV2t021472001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021472001.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	PANTHER
NV2t021472001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021473001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021473001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021476001.1	biological_process	GO:0006826	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t021476001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t021476001.1	biological_process	GO:0051651	maintenance of location in cell	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]	OMA
NV2t021476001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021476001.1	molecular_function	GO:0004322	ferroxidase activity	"Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [RHEA:11148]	OMA
NV2t021476001.1	molecular_function	GO:0008198	ferrous iron binding	"Binding to a ferrous iron ion, Fe(II)." [GOC:ai]	OMA
NV2t021476001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t021476001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t021477001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021477002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021477003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021481001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t021481001.1	biological_process	GO:0019236	response to pheromone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]	InterPro
NV2t021481001.1	biological_process	GO:0019236	response to pheromone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]	OMA
NV2t021485001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021485002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021487001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021495001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021495001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t021495002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021495003.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021496001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021496002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021497001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021498001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021498002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021498003.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021498003.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t021498004.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021499001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021499001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t021500001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021501001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021501001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t021501002.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t021508001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021508001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021508001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021508001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021509001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t021509001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t021513001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021516001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	InterPro
NV2t021516001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t021516001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t021516001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021516001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	InterPro
NV2t021516001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021517001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021517001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021518001.1	biological_process	GO:0036149	phosphatidylinositol acyl-chain remodeling	"Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains." [GOC:mw, PMID:18094042, PMID:18772128]	PANTHER
NV2t021518001.1	biological_process	GO:0046488	phosphatidylinositol metabolic process	"The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]	OMA
NV2t021518001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021518001.1	molecular_function	GO:0016411	acylglycerol O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]	OMA
NV2t021518001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021518001.1	molecular_function	GO:0042171	lysophosphatidic acid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]	OMA
NV2t021518002.1	biological_process	GO:0036149	phosphatidylinositol acyl-chain remodeling	"Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains." [GOC:mw, PMID:18094042, PMID:18772128]	PANTHER
NV2t021518002.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021519001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t021519001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t021519001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t021519001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t021519001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t021519001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t021522001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t021522001.1	biological_process	GO:0030150	protein import into mitochondrial matrix	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]	InterPro
NV2t021522001.1	biological_process	GO:0030150	protein import into mitochondrial matrix	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]	PANTHER
NV2t021522001.1	biological_process	GO:0044743	protein transmembrane import into intracellular organelle	"The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]	OMA
NV2t021522001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021522001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t021522001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t021522001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t021522001.1	molecular_function	GO:0022884	macromolecule transmembrane transporter activity	"Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021522001.1	molecular_function	GO:0140318	protein transporter activity	"Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]	OMA
NV2t021523001.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t021523001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t021523001.1	biological_process	GO:0007417	central nervous system development	"The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089]	OMA
NV2t021523001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t021523001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t021523001.1	biological_process	GO:0030576	Cajal body organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238]	OMA
NV2t021523001.1	biological_process	GO:0033120	positive regulation of RNA splicing	"Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah]	OMA
NV2t021523001.1	biological_process	GO:0042023	DNA endoreduplication	"Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]	OMA
NV2t021523001.1	biological_process	GO:0042307	positive regulation of protein import into nucleus	"Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl]	OMA
NV2t021523001.1	biological_process	GO:0045787	positive regulation of cell cycle	"Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]	OMA
NV2t021523001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021523001.1	biological_process	GO:0045927	positive regulation of growth	"Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]	OMA
NV2t021523001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t021523001.1	biological_process	GO:0048589	developmental growth	"The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]	OMA
NV2t021523001.1	biological_process	GO:0051960	regulation of nervous system development	"Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	OMA
NV2t021523001.1	biological_process	GO:0061564	axon development	"The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr]	OMA
NV2t021523001.1	biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]	OMA
NV2t021523001.1	biological_process	GO:1902742	apoptotic process involved in development	"Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie]	OMA
NV2t021523001.1	biological_process	GO:1990261	pre-mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA)." [GOC:rb, PMID:22844259]	OMA
NV2t021523001.1	biological_process	GO:2000672	negative regulation of motor neuron apoptotic process	"Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]	OMA
NV2t021523001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t021523001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021523001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021523001.1	cellular_component	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	OMA
NV2t021523001.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t021523001.1	cellular_component	GO:0043204	perikaryon	"The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl]	OMA
NV2t021523001.1	cellular_component	GO:0097504	Gemini of coiled bodies	"Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, PMID:11031238, PMID:9683623, Wikipedia:Cell_nucleus#Cajal_bodies_and_gems]	OMA
NV2t021523001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021523001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021523001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	OMA
NV2t021526001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021528001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021528002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021530001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t021530001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021530001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021530002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t021530002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021530002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021531001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t021531001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t021531001.1	cellular_component	GO:0033551	monopolin complex	"A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824]	InterPro
NV2t021531001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021533001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021533001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021533001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t021533001.1	molecular_function	GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]	OMA
NV2t021533001.1	molecular_function	GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]	PANTHER
NV2t021533001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t021534001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t021534001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t021534001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	PANTHER
NV2t021534001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	InterPro
NV2t021534001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t021534001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t021534001.1	biological_process	GO:0045739	positive regulation of DNA repair	"Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators]	OMA
NV2t021534001.1	biological_process	GO:0050881	musculoskeletal movement	"The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph]	OMA
NV2t021534001.1	biological_process	GO:0051348	negative regulation of transferase activity	"Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]	OMA
NV2t021534001.1	biological_process	GO:0051351	positive regulation of ligase activity	"Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]	OMA
NV2t021534001.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t021534001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t021534001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t021534001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t021534001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t021534001.1	molecular_function	GO:0032356	oxidized DNA binding	"Binding to a DNA region containing an oxidized residue." [GOC:vk]	OMA
NV2t021535001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021535001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t021535001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t021535001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021535001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021535002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021535002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t021535002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021535003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021535003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t021535003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021537001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021537001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t021541001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t021541001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021541001.1	biological_process	GO:0098659	inorganic cation import across plasma membrane	"The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t021541001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t021541001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021541001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021541001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t021541001.1	molecular_function	GO:0015385	sodium:proton antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]	OMA
NV2t021541001.1	molecular_function	GO:0015386	potassium:proton antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-]	OMA
NV2t021542001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021544001.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t021544001.1	biological_process	GO:0009308	amine metabolic process	"The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]	OMA
NV2t021544001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t021544001.1	molecular_function	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t021544001.1	molecular_function	GO:0048038	quinone binding	"Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732]	InterPro
NV2t021549001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021550001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t021550001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t021550001.1	biological_process	GO:0046314	phosphocreatine biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]	PANTHER
NV2t021550001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t021550001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t021550001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t021550001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021551001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t021559001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t021559001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t021559001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	InterPro
NV2t021559001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	OMA
NV2t021560001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t021560001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t021560001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t021560001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t021560001.1	cellular_component	GO:0097730	non-motile cilium	"A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t021560001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021561001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t021561001.1	biological_process	GO:0030003	intracellular monoatomic cation homeostasis	"A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom." [GOC:ceb, GOC:mah]	OMA
NV2t021561001.1	biological_process	GO:0042391	regulation of membrane potential	"Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]	OMA
NV2t021561001.1	biological_process	GO:0050789	regulation of biological process	"Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]	OMA
NV2t021561001.1	biological_process	GO:0098659	inorganic cation import across plasma membrane	"The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t021561001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t021561001.1	biological_process	GO:0106027	neuron projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923]	OMA
NV2t021561001.1	biological_process	GO:0140115	export across plasma membrane	"The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg]	OMA
NV2t021561001.1	biological_process	GO:1901653	cellular response to peptide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t021561001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	OMA
NV2t021561001.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021561001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021561001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t021561001.1	cellular_component	GO:0005890	sodium:potassium-exchanging ATPase complex	"Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732]	OMA
NV2t021561001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021561001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t021561001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t021561001.1	cellular_component	GO:0043025	neuronal cell body	"The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]	OMA
NV2t021561001.1	cellular_component	GO:0098590	plasma membrane region	"A membrane that is a (regional) part of the plasma membrane." [GOC:dos]	OMA
NV2t021561001.1	cellular_component	GO:0098984	neuron to neuron synapse	"A synapse in which pre and post-synaptic cells are neurons." [GOC:dos]	OMA
NV2t021561001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021561001.1	molecular_function	GO:0001540	amyloid-beta binding	"Binding to an amyloid-beta peptide/protein." [GOC:hjd]	OMA
NV2t021561001.1	molecular_function	GO:0005391	P-type sodium:potassium-exchanging transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:7.2.2.13]	OMA
NV2t021561001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021561001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021561001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t021561001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t021561002.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021561002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021561002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021561002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021561003.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021561003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021561003.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021561003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021561004.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021561004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021561004.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021561004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021561005.1	biological_process	GO:1990573	potassium ion import across plasma membrane	"The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]	PANTHER
NV2t021561005.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t021561005.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021563001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	InterPro
NV2t021563001.1	biological_process	GO:0060294	cilium movement involved in cell motility	"Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]	PANTHER
NV2t021564001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t021564001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t021564001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t021564001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t021564001.1	molecular_function	GO:0004721	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]	InterPro
NV2t021564001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t021564001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t021564001.1	molecular_function	GO:0008962	phosphatidylglycerophosphatase activity	"Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [PMID:4292860]	PANTHER
NV2t021564001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t021564001.1	molecular_function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah]	OMA
NV2t021565001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t021565001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t021565001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t021565001.1	cellular_component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	"Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]	OMA
NV2t021565001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t021565001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	InterPro
NV2t021565001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t021565001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t021565001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t021565001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	OMA
NV2t021565001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	PANTHER
NV2t021566001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021566001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t021566001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t021566001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021567001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t021567001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t021567001.1	cellular_component	GO:1990071	TRAPPII protein complex	"A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]	OMA
NV2t021567001.1	cellular_component	GO:1990071	TRAPPII protein complex	"A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]	PANTHER
NV2t021567001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t021567002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t021567002.1	cellular_component	GO:1990071	TRAPPII protein complex	"A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]	PANTHER
NV2t021568001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t021568001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021569001.1	cellular_component	GO:0071986	Ragulator complex	"A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]	InterPro
NV2t021570001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	OMA
NV2t021570001.1	biological_process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	InterPro
NV2t021570001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t021570001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t021570001.1	biological_process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	"Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t021570001.1	biological_process	GO:0046339	diacylglycerol metabolic process	"The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11481335]	OMA
NV2t021570001.1	biological_process	GO:0046473	phosphatidic acid metabolic process	"The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]	OMA
NV2t021570001.1	biological_process	GO:0046474	glycerophospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t021570001.1	biological_process	GO:0046834	lipid phosphorylation	"The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732]	OMA
NV2t021570001.1	biological_process	GO:0046834	lipid phosphorylation	"The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732]	PANTHER
NV2t021570001.1	biological_process	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t021570001.1	biological_process	GO:2000370	positive regulation of clathrin-dependent endocytosis	"Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:BHF, GOC:mah]	OMA
NV2t021570001.1	cellular_component	GO:0005905	clathrin-coated pit	"A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835]	OMA
NV2t021570001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t021570001.1	molecular_function	GO:0004143	ATP-dependent diacylglycerol kinase activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+." [GOC:elh, RHEA:10272]	OMA
NV2t021570001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021570001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t021570001.1	molecular_function	GO:0019900	kinase binding	"Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]	OMA
NV2t021570001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t021570001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t021570002.1	biological_process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	"The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling]	InterPro
NV2t021570002.1	biological_process	GO:0046834	lipid phosphorylation	"The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732]	PANTHER
NV2t021570002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t021572001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	OMA
NV2t021572001.1	biological_process	GO:0007076	mitotic chromosome condensation	"The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t021572001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t021572001.1	biological_process	GO:0060623	regulation of chromosome condensation	"Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb]	OMA
NV2t021572001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t021572001.1	cellular_component	GO:0000793	condensed chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]	OMA
NV2t021572001.1	cellular_component	GO:0000796	condensin complex	"A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis." [GOC:elh, PMID:17268547, PMID:21795393]	OMA
NV2t021572001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021572001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t021572001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t021572001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t021572001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021572001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021572001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021572001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t021575001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t021581001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t021581001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021582001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t021586002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021587002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021591001.1	biological_process	GO:0006307	DNA alkylation repair	"The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases." [PMID:10946226, PMID:35543797]	InterPro
NV2t021591001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021591001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021591001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021591001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t021591001.1	cellular_component	GO:0031594	neuromuscular junction	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]	OMA
NV2t021591001.1	cellular_component	GO:1990391	DNA repair complex	"A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]	OMA
NV2t021591001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021591001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t021591001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021592001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021593001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t021593001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t021593001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t021593001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t021593001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t021593001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t021593001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t021593001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t021595001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t021595001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t021595001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	OMA
NV2t021595001.1	biological_process	GO:0032024	positive regulation of insulin secretion	"Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah]	OMA
NV2t021595001.1	biological_process	GO:0035336	long-chain fatty-acyl-CoA metabolic process	"The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]	PANTHER
NV2t021595001.1	biological_process	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	"The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]	OMA
NV2t021595001.1	biological_process	GO:0045017	glycerolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t021595001.1	biological_process	GO:1905952	regulation of lipid localization	"Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681]	OMA
NV2t021595001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t021595001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021595001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t021595001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021595001.1	cellular_component	GO:0044233	mitochondria-associated endoplasmic reticulum membrane contact site	"A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109]	OMA
NV2t021595001.1	molecular_function	GO:0004467	long-chain fatty acid-CoA ligase activity	"Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [RHEA:15421]	OMA
NV2t021600001.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	OMA
NV2t021600001.1	biological_process	GO:0032507	maintenance of protein location in cell	"Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]	OMA
NV2t021600001.1	biological_process	GO:0042989	sequestering of actin monomers	"The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators]	PANTHER
NV2t021600001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t021600001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t021600001.1	molecular_function	GO:0003785	actin monomer binding	"Binding to monomeric actin, also known as G-actin." [GOC:ai]	OMA
NV2t021601001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t021601001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t021601001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	PANTHER
NV2t021601001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t021601001.1	cellular_component	GO:0005674	transcription factor TFIIF complex	"A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]	OMA
NV2t021601001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t021603001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t021603001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	InterPro
NV2t021603001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t021603001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t021603001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t021603001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t021603001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021604001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021604001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021604001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t021604002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021604003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021604004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021604005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021604006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021605001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t021607001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021609001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t021609001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t021609001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021609001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t021609001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t021609001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t021611001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t021611001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t021611001.1	molecular_function	GO:0033781	cholesterol 24-hydroxylase activity	"Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+." [EC:1.14.14.25, RHEA:22716]	PANTHER
NV2t021613001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t021613001.1	biological_process	GO:0030510	regulation of BMP signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]	OMA
NV2t021613001.1	biological_process	GO:0030510	regulation of BMP signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]	PANTHER
NV2t021613001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t021613001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t021613001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021613001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021613001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021614001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t021614001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t021614001.1	biological_process	GO:0006303	double-strand break repair via nonhomologous end joining	"The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021]	OMA
NV2t021614001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t021614001.1	biological_process	GO:0007127	meiosis I	"The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324]	OMA
NV2t021614001.1	biological_process	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw]	OMA
NV2t021614001.1	biological_process	GO:0042138	meiotic DNA double-strand break formation	"The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]	OMA
NV2t021614001.1	biological_process	GO:0097552	mitochondrial double-strand break repair via homologous recombination	"The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:di, PMID:22214610]	PANTHER
NV2t021614001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t021614001.1	cellular_component	GO:0030870	Mre11 complex	"Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]	InterPro
NV2t021614001.1	cellular_component	GO:0030870	Mre11 complex	"Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]	OMA
NV2t021614001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t021614001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t021614001.1	molecular_function	GO:0004520	DNA endonuclease activity	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t021614001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021614001.1	molecular_function	GO:0008296	3'-5'-DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]	OMA
NV2t021614001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021614001.1	molecular_function	GO:0030145	manganese ion binding	"Binding to a manganese ion (Mn)." [GOC:ai]	InterPro
NV2t021614001.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t021614002.1	biological_process	GO:0097552	mitochondrial double-strand break repair via homologous recombination	"The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:di, PMID:22214610]	PANTHER
NV2t021614002.1	cellular_component	GO:0030870	Mre11 complex	"Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]	InterPro
NV2t021614002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021614002.1	molecular_function	GO:0030145	manganese ion binding	"Binding to a manganese ion (Mn)." [GOC:ai]	InterPro
NV2t021615001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021615001.1	biological_process	GO:0006810	transport	"The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t021615001.1	biological_process	GO:0006996	organelle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t021615001.1	biological_process	GO:0008286	insulin receptor signaling pathway	"The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]	OMA
NV2t021615001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t021615001.1	biological_process	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t021615001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t021615001.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t021615001.1	biological_process	GO:0030010	establishment of cell polarity	"The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t021615001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t021615001.1	biological_process	GO:0048468	cell development	"The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place." [GOC:go_curators]	OMA
NV2t021615001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t021615001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t021615001.1	biological_process	GO:0051050	positive regulation of transport	"Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t021615001.1	biological_process	GO:0051130	positive regulation of cellular component organization	"Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t021615001.1	biological_process	GO:0051649	establishment of localization in cell	"Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]	OMA
NV2t021615001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	OMA
NV2t021615001.1	biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t021615001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	OMA
NV2t021615001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t021615001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	OMA
NV2t021615001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021615001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021615001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t021615001.1	cellular_component	GO:0030877	beta-catenin destruction complex	"A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]	OMA
NV2t021615001.1	cellular_component	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	OMA
NV2t021615001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t021615001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021615001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021615001.1	molecular_function	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	OMA
NV2t021615001.1	molecular_function	GO:0050321	tau-protein kinase activity	"Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]	OMA
NV2t021616001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t021616001.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	InterPro
NV2t021616001.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	OMA
NV2t021616001.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	PANTHER
NV2t021616001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t021617001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t021617001.1	biological_process	GO:0034644	cellular response to UV	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]	OMA
NV2t021617001.1	biological_process	GO:2000435	negative regulation of protein neddylation	"Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol]	OMA
NV2t021617001.1	biological_process	GO:2000435	negative regulation of protein neddylation	"Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol]	PANTHER
NV2t021617001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t021617001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t021617001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021617001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	OMA
NV2t021617002.1	biological_process	GO:2000435	negative regulation of protein neddylation	"Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol]	PANTHER
NV2t021617003.1	biological_process	GO:2000435	negative regulation of protein neddylation	"Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol]	PANTHER
NV2t021618001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t021618001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021618001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t021618001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t021618001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t021618002.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t021619001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t021619001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t021619001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t021621001.1	cellular_component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	"An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]	PANTHER
NV2t021621001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021621001.1	molecular_function	GO:0031369	translation initiation factor binding	"Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]	InterPro
NV2t021622001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t021622001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t021622001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021622001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t021624001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t021624001.1	biological_process	GO:0050804	modulation of chemical synaptic transmission	"Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai]	OMA
NV2t021624001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	OMA
NV2t021624001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t021624001.1	molecular_function	GO:0042043	neurexin family protein binding	"Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512]	OMA
NV2t021626001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t021626001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t021626001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t021626001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t021628001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021629001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021629002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021630001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021631001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t021631001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t021631001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021634001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021635001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021636001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021636001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t021636001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t021636001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t021636001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021636001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t021636001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021636001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t021636001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021638001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021638001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t021638001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t021638001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t021638001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021638001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t021638001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021638002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021638002.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t021638002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t021638002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021639001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t021639001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021639001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t021639001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t021640001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	PANTHER
NV2t021641001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t021641001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021641001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t021641001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t021641001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021645001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021645001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021645001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021646002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021646002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021646003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021646003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021646004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021646004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021647001.1	biological_process	GO:0045004	DNA replication proofreading	"Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai]	PANTHER
NV2t021647001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021647002.1	biological_process	GO:0000082	G1/S transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle]	OMA
NV2t021647002.1	biological_process	GO:0000731	DNA synthesis involved in DNA repair	"Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855]	OMA
NV2t021647002.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t021647002.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t021647002.1	biological_process	GO:0045004	DNA replication proofreading	"Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai]	OMA
NV2t021647002.1	biological_process	GO:0045004	DNA replication proofreading	"Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai]	PANTHER
NV2t021647002.1	cellular_component	GO:0008622	epsilon DNA polymerase complex	"A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]	OMA
NV2t021647002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t021647002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021647002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021647002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t021647002.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t021647002.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	InterPro
NV2t021647002.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t021647002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021647002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021647002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021647002.1	molecular_function	GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]	OMA
NV2t021648001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021648001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021648001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t021648001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021649001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t021650001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021650001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021650001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021651001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021651001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021651001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t021651001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021651002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t021651002.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	PANTHER
NV2t021653001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t021653001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021656001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t021656001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t021656001.1	cellular_component	GO:0005664	nuclear origin of replication recognition complex	"A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]	OMA
NV2t021656001.1	cellular_component	GO:0031261	DNA replication preinitiation complex	"A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184]	OMA
NV2t021656001.1	cellular_component	GO:0031261	DNA replication preinitiation complex	"A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184]	PANTHER
NV2t021656001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t021656002.1	cellular_component	GO:0031261	DNA replication preinitiation complex	"A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184]	PANTHER
NV2t021657001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021659001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021659001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021659001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021659001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t021659002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021659002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021659003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021659003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021664001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021664001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t021664001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021664001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021664001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021664001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021664001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	PANTHER
NV2t021666001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021667001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t021669001.1	biological_process	GO:0006779	porphyrin-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation]	InterPro
NV2t021669001.1	biological_process	GO:0018130	obsolete heterocycle biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]	OMA
NV2t021669001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t021669001.1	biological_process	GO:0042168	heme metabolic process	"The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]	OMA
NV2t021669001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t021669001.1	biological_process	GO:0046148	pigment biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732]	OMA
NV2t021669001.1	biological_process	GO:1901362	organic cyclic compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie]	OMA
NV2t021669001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t021669001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t021669001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t021669001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t021669001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t021670001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	PANTHER
NV2t021671001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t021671001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t021672001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t021672001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t021672001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t021672001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t021673001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t021673001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t021673001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t021673001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	PANTHER
NV2t021673001.1	biological_process	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	"Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie]	OMA
NV2t021673001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t021673001.1	cellular_component	GO:0031391	Elg1 RFC-like complex	"A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842, PMID:23499004, PMID:27664980]	OMA
NV2t021673001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t021673001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t021673001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021673001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021673001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021673001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t021673001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t021674001.1	biological_process	GO:0030837	negative regulation of actin filament polymerization	"Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]	OMA
NV2t021674001.1	biological_process	GO:0032507	maintenance of protein location in cell	"Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]	OMA
NV2t021674001.1	biological_process	GO:0042989	sequestering of actin monomers	"The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators]	PANTHER
NV2t021674001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t021674001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t021674001.1	molecular_function	GO:0003785	actin monomer binding	"Binding to monomeric actin, also known as G-actin." [GOC:ai]	OMA
NV2t021676001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t021676001.1	molecular_function	GO:0043539	protein serine/threonine kinase activator activity	"Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]	OMA
NV2t021676001.1	molecular_function	GO:0043539	protein serine/threonine kinase activator activity	"Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]	PANTHER
NV2t021677001.1	biological_process	GO:0006073	obsolete cellular glucan metabolic process	"OBSOLETE. The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell." [ISBN:0198547684]	OMA
NV2t021677001.1	biological_process	GO:0009251	glucan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]	OMA
NV2t021677001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t021677001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t021677001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t021677001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t021677001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t021678001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t021678001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	OMA
NV2t021678001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t021678001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t021678002.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t021678002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t021679001.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	InterPro
NV2t021679001.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	OMA
NV2t021679001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	OMA
NV2t021679001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	PANTHER
NV2t021679001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021679001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021679001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t021679001.1	molecular_function	GO:0016776	phosphotransferase activity, phosphate group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]	OMA
NV2t021679002.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	InterPro
NV2t021679002.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	PANTHER
NV2t021679003.1	biological_process	GO:0032958	inositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah]	InterPro
NV2t021679003.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	PANTHER
NV2t021680001.1	biological_process	GO:1901911	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	"The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752]	PANTHER
NV2t021680001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	InterPro
NV2t021680001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021680002.1	biological_process	GO:0009154	purine ribonucleotide catabolic process	"The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t021680002.1	biological_process	GO:0043647	inositol phosphate metabolic process	"The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:jl]	OMA
NV2t021680002.1	biological_process	GO:1901911	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	"The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752]	PANTHER
NV2t021680002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021680002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021680002.1	molecular_function	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity	"Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate." [EC:3.6.1.52]	OMA
NV2t021680002.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	InterPro
NV2t021680002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021680002.1	molecular_function	GO:0034431	bis(5'-adenosyl)-hexaphosphatase activity	"Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008, RHEA:32047]	OMA
NV2t021680002.1	molecular_function	GO:0050072	obsolete m7G(5')pppN diphosphatase activity	"OBSOLETE. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [GOC:curators]	OMA
NV2t021680003.1	biological_process	GO:1901911	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	"The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752]	PANTHER
NV2t021680003.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	InterPro
NV2t021680003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021680004.1	biological_process	GO:1901911	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	"The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752]	PANTHER
NV2t021680004.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	InterPro
NV2t021680004.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021682001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t021682001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021683001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	PANTHER
NV2t021684001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021684001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t021684001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t021684001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t021684001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021684001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021684001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021686001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	PANTHER
NV2t021687001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021687001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t021687001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t021687001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t021687001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021687001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021687001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021689001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	PANTHER
NV2t021691001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t021703001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t021703001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t021703001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t021703001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t021703001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t021703001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t021703001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t021704001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021707001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t021707001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t021707001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t021707001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t021707001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t021707001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t021708001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t021708001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021711001.1	biological_process	GO:0016575	obsolete histone deacetylation	"OBSOLETE. The modification of histones by removal of acetyl groups." [GOC:ai]	InterPro
NV2t021711001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021712001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021712001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021715001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t021715001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t021715001.1	biological_process	GO:0046185	aldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]	OMA
NV2t021715001.1	biological_process	GO:0046294	formaldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]	InterPro
NV2t021715001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t021715001.1	biological_process	GO:1990748	cellular detoxification	"Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw]	OMA
NV2t021715001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021715001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t021715002.1	biological_process	GO:0046294	formaldehyde catabolic process	"The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]	InterPro
NV2t021716001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t021716001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t021716001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t021716001.1	biological_process	GO:0046580	negative regulation of Ras protein signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	PANTHER
NV2t021716001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021716002.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t021716002.1	biological_process	GO:0046580	negative regulation of Ras protein signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	PANTHER
NV2t021716002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021719001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021719001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t021719001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t021719001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021719001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021719001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021725001.1	biological_process	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	OMA
NV2t021725001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t021725001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t021725001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t021725001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t021725001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t021725001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t021725001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t021728001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021728001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021729001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t021729001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021730001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021730001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021732001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t021733001.1	biological_process	GO:0000281	mitotic cytokinesis	"A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle]	OMA
NV2t021733001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t021733001.1	biological_process	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t021733001.1	biological_process	GO:0060285	cilium-dependent cell motility	"Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013]	OMA
NV2t021733001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t021733001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t021733001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t021733001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t021733001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t021733001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021733001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021733001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t021736001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t021736001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t021736001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t021736001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021736001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021736001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t021737001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t021737001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021738001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021739001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t021739001.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t021739001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021739001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021739001.1	molecular_function	GO:0017147	Wnt-protein binding	"Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]	OMA
NV2t021739001.1	molecular_function	GO:0042813	Wnt receptor activity	"Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]	OMA
NV2t021741001.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t021741001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021743001.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t021743001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021749001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021749001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t021749001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t021749001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t021749001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021749001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021749001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021750001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	PANTHER
NV2t021751001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021751001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021751001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021756001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t021756001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t021756001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t021756001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t021756001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t021756001.1	biological_process	GO:0030334	regulation of cell migration	"Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t021756001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t021756001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t021756001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t021756001.1	biological_process	GO:0060997	dendritic spine morphogenesis	"The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]	OMA
NV2t021756001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021756001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021756001.1	cellular_component	GO:0043197	dendritic spine	"A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]	OMA
NV2t021756001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t021756001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021756002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t021756003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t021757001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021763001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t021763001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t021763001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t021764001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021766001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t021766001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021766001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t021767001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t021767001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021769001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021769001.1	molecular_function	GO:0015234	thiamine transmembrane transporter activity	"Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021769001.1	molecular_function	GO:0090482	vitamin transmembrane transporter activity	"Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb]	InterPro
NV2t021770001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t021770001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021771001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t021771001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t021771001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t021771001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021771001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t021771001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021773002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	InterPro
NV2t021773002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	OMA
NV2t021773002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t021773002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021773002.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t021773002.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021774001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021774001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t021774001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t021774001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021774001.1	molecular_function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]	OMA
NV2t021774002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021774002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t021774003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021774003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t021774004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021774004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t021774005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021774005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t021774006.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021774006.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t021775001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021775002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021775003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021775004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t021775004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021776001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t021776001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021776002.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t021776002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021777001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t021777001.1	cellular_component	GO:0036513	Derlin-1 retrotranslocation complex	"A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]	PANTHER
NV2t021778001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t021778001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021778002.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	PANTHER
NV2t021778002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021779001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t021779001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t021779001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t021779001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t021779001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021779001.1	cellular_component	GO:0036513	Derlin-1 retrotranslocation complex	"A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]	PANTHER
NV2t021779001.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t021779001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t021780001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t021780001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t021780002.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t021780002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t021780002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t021780002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t021781001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t021781001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t021781001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	OMA
NV2t021781001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021781001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t021781001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t021781002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t021781002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021781002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t021781003.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t021781003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021781003.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t021782001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021783001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t021783001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	OMA
NV2t021783001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t021783001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021783001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t021783002.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t021783002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021784001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t021784001.1	biological_process	GO:0043406	positive regulation of MAP kinase activity	"Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t021784001.1	biological_process	GO:1903358	regulation of Golgi organization	"Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]	OMA
NV2t021784001.1	biological_process	GO:1903358	regulation of Golgi organization	"Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]	PANTHER
NV2t021784001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t021784001.1	cellular_component	GO:0090443	FAR/SIN/STRIPAK complex	"A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body." [GOC:vw, PMID:21561862, PMID:22119525]	OMA
NV2t021784001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t021788001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021788001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021788001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t021788001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021793001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021794001.1	biological_process	GO:0002698	negative regulation of immune effector process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]	OMA
NV2t021794001.1	biological_process	GO:0002699	positive regulation of immune effector process	"Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]	OMA
NV2t021794001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t021794001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t021794001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t021794001.1	biological_process	GO:0007000	nucleolus organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah]	OMA
NV2t021794001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t021794001.1	biological_process	GO:0009892	negative regulation of metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t021794001.1	biological_process	GO:0009893	positive regulation of metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t021794001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t021794001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t021794001.1	biological_process	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	OMA
NV2t021794001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t021794001.1	biological_process	GO:0045089	positive regulation of innate immune response	"Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]	OMA
NV2t021794001.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t021794001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t021794001.1	biological_process	GO:0050728	negative regulation of inflammatory response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]	OMA
NV2t021794001.1	biological_process	GO:0050729	positive regulation of inflammatory response	"Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]	OMA
NV2t021794001.1	biological_process	GO:0050829	defense response to Gram-negative bacterium	"Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]	OMA
NV2t021794001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t021794001.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t021794001.1	biological_process	GO:0060284	regulation of cell development	"Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]	OMA
NV2t021794001.1	biological_process	GO:0060326	cell chemotaxis	"The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]	OMA
NV2t021794001.1	biological_process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	"An immune response against microbes mediated by anti-microbial peptides in body fluid." [PMID:15761415, PMID:24287494]	OMA
NV2t021794001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t021794001.1	cellular_component	GO:0014069	postsynaptic density	"An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]	OMA
NV2t021794001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t021794001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t021794001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t021794001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t021794001.1	molecular_function	GO:0019838	growth factor binding	"Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators]	OMA
NV2t021794001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t021794001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t021803001.1	molecular_function	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	InterPro
NV2t021806001.1	biological_process	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	"The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579]	PANTHER
NV2t021811001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t021811001.1	biological_process	GO:0036159	inner dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t021811001.1	biological_process	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	"The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579]	PANTHER
NV2t021811001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t021814001.1	molecular_function	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	InterPro
NV2t021822001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021822002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021822003.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021825001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t021825001.1	molecular_function	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	OMA
NV2t021827001.1	biological_process	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry	"The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579]	PANTHER
NV2t021828001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021828001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t021828001.1	molecular_function	GO:0005055	laminin receptor activity	"Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671]	OMA
NV2t021828001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021831001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t021831001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t021831001.1	biological_process	GO:0022904	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	OMA
NV2t021831001.1	biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	"A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]	PANTHER
NV2t021831001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t021831001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t021831001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	InterPro
NV2t021831001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t021833001.1	biological_process	GO:0015813	L-glutamate transmembrane transport	"The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	PANTHER
NV2t021833001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021833002.1	biological_process	GO:0015813	L-glutamate transmembrane transport	"The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	PANTHER
NV2t021833002.1	biological_process	GO:0070778	L-aspartate transmembrane transport	"The directed movement of L-aspartate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	OMA
NV2t021833002.1	biological_process	GO:0072348	sulfur compound transport	"The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t021833002.1	biological_process	GO:0089718	amino acid import across plasma membrane	"The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186]	OMA
NV2t021833002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021833002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021833002.1	molecular_function	GO:0005313	L-glutamate transmembrane transporter activity	"Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021833002.1	molecular_function	GO:0015175	neutral L-amino acid transmembrane transporter activity	"Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t021833002.1	molecular_function	GO:0015501	glutamate:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1]	OMA
NV2t021833002.1	molecular_function	GO:1901682	sulfur compound transmembrane transporter activity	"Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t021833003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021833003.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t021833004.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021833004.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t021833005.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t021833005.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t021836001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021836001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t021836002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021837001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t021842001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t021842001.1	biological_process	GO:0007020	microtubule nucleation	"The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712]	OMA
NV2t021842001.1	biological_process	GO:0031122	cytoplasmic microtubule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t021842001.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	OMA
NV2t021842001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	OMA
NV2t021842001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t021842001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021842001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t021842001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t021842001.1	cellular_component	GO:0005827	polar microtubule	"Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194]	OMA
NV2t021842001.1	cellular_component	GO:0008275	gamma-tubulin small complex	"A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075]	OMA
NV2t021842001.1	cellular_component	GO:0032153	cell division site	"The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305]	OMA
NV2t021842001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	InterPro
NV2t021842001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	OMA
NV2t021842001.1	molecular_function	GO:0051011	microtubule minus-end binding	"Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	OMA
NV2t021842002.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t021842002.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	InterPro
NV2t021842003.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t021842003.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	InterPro
NV2t021846001.1	biological_process	GO:0016180	snRNA processing	"Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres." [PMID:15196465, PMID:31815536]	OMA
NV2t021846001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	OMA
NV2t021846001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	PANTHER
NV2t021848001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t021848001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t021848001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t021848001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t021848001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t021848001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	PANTHER
NV2t021848001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	InterPro
NV2t021848001.1	molecular_function	GO:0008092	cytoskeletal protein binding	"Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]	OMA
NV2t021850001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021850001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t021850001.1	biological_process	GO:0032793	positive regulation of CREB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]	InterPro
NV2t021850001.1	biological_process	GO:0032793	positive regulation of CREB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]	OMA
NV2t021850001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t021850001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t021850001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t021850001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t021850001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021850001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021850001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021851001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t021851001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t021851001.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t021851001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t021851001.1	biological_process	GO:0048585	negative regulation of response to stimulus	"Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t021851001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	OMA
NV2t021851001.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	OMA
NV2t021851001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t021851001.1	biological_process	GO:1901799	negative regulation of proteasomal protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t021851001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021851001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021851001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021851001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t021851001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t021851001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t021851001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t021851001.1	molecular_function	GO:0032183	SUMO binding	"Binding to the small ubiquitin-like protein SUMO." [GOC:mah]	OMA
NV2t021851002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t021851002.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t021851002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t021851002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021852001.1	biological_process	GO:0046331	lateral inhibition	"Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]	OMA
NV2t021853001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t021853001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t021853001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021853002.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t021853002.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t021853002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021853002.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	InterPro
NV2t021853003.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t021853003.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t021853003.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	PANTHER
NV2t021853003.1	cellular_component	GO:0033176	proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t021853003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021853003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021853003.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t021853003.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t021853003.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t021855001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021855001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t021855001.1	molecular_function	GO:0005055	laminin receptor activity	"Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671]	OMA
NV2t021855001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021856001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t021856001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021856001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021856001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021856001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021856001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t021856001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t021857002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021857002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021858001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021858001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021858002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021858002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021858003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021858003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021858004.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021858004.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021858005.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021858005.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021858006.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021858006.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021858007.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021858007.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t021859001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t021859001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t021859001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t021859001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t021859001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t021860001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t021860001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t021860001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t021860001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t021860001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021860001.1	molecular_function	GO:0015038	glutathione disulfide oxidoreductase activity	"Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah]	OMA
NV2t021860001.1	molecular_function	GO:0016209	antioxidant activity	"Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]	OMA
NV2t021860001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t021860001.1	molecular_function	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t021860001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t021860001.1	molecular_function	GO:0047134	protein-disulfide reductase (NAD(P)H) activity	"Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]	OMA
NV2t021860001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t021860001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t021860001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t021860001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t021861001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021861001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021862001.1	biological_process	GO:0019441	tryptophan catabolic process to kynurenine	"The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]	OMA
NV2t021862001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021862001.1	molecular_function	GO:0004061	arylformamidase activity	"Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9]	OMA
NV2t021862001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t021862001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t021863001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t021864001.1	biological_process	GO:0070861	regulation of protein exit from endoplasmic reticulum	"Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021864001.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021864001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	OMA
NV2t021864001.1	biological_process	GO:0090317	negative regulation of intracellular protein transport	"Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb]	OMA
NV2t021864001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021864001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021864001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t021864001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t021864001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021865001.1	biological_process	GO:0001933	negative regulation of protein phosphorylation	"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t021865001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t021865001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t021865001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t021865001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t021865001.1	biological_process	GO:0036490	regulation of translation in response to endoplasmic reticulum stress	"Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]	OMA
NV2t021865001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t021865001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t021865001.1	biological_process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t021865001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021865001.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	OMA
NV2t021865001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	OMA
NV2t021865001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t021865001.1	molecular_function	GO:0046875	ephrin receptor binding	"Binding to an ephrin receptor." [GOC:ai]	OMA
NV2t021866001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t021866001.1	biological_process	GO:0007480	imaginal disc-derived leg morphogenesis	"The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]	OMA
NV2t021866001.1	biological_process	GO:0007483	genital disc morphogenesis	"The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]	OMA
NV2t021866001.1	biological_process	GO:0008544	epidermis development	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]	OMA
NV2t021866001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t021866001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t021866001.1	biological_process	GO:0042659	regulation of cell fate specification	"Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators]	OMA
NV2t021866001.1	biological_process	GO:0045664	regulation of neuron differentiation	"Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]	OMA
NV2t021866001.1	biological_process	GO:0051450	myoblast proliferation	"The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]	OMA
NV2t021866001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021866001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t021866001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021866001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t021870001.1	biological_process	GO:0001558	regulation of cell growth	"Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t021870001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	PANTHER
NV2t021870001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t021870001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t021870001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	OMA
NV2t021870001.1	molecular_function	GO:0005520	insulin-like growth factor binding	"Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732]	OMA
NV2t021871001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t021871001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t021871001.1	molecular_function	GO:0032934	sterol binding	"Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah]	PANTHER
NV2t021872001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t021872001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t021872001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t021872001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021872001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	OMA
NV2t021872001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	PANTHER
NV2t021873001.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	InterPro
NV2t021873001.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	PANTHER
NV2t021873002.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	InterPro
NV2t021873002.1	cellular_component	GO:0030008	TRAPP complex	"A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]	PANTHER
NV2t021874001.1	biological_process	GO:0009301	snRNA transcription	"The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382]	OMA
NV2t021874001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t021874001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	PANTHER
NV2t021874001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	InterPro
NV2t021874001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t021875001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t021875001.1	biological_process	GO:0009725	response to hormone	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]	OMA
NV2t021875001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	OMA
NV2t021875001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	PANTHER
NV2t021875001.1	cellular_component	GO:0044665	MLL1/2 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t021875001.1	cellular_component	GO:0044666	MLL3/4 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t021875001.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	OMA
NV2t021875001.1	molecular_function	GO:0000976	transcription cis-regulatory region binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]	OMA
NV2t021875001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021875001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t021876001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021878001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t021878001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t021878001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021878001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021878001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t021878001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t021879002.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t021879002.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t021879002.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t021879003.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t021879003.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t021879003.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t021880001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t021880001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t021880001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t021880001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t021880001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t021880001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t021880001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t021880001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t021880001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021880001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t021880002.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t021880002.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t021880002.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t021881001.1	biological_process	GO:0006644	phospholipid metabolic process	"The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t021881001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	OMA
NV2t021881001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t021881001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	InterPro
NV2t021881001.1	biological_process	GO:0016042	lipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t021881001.1	biological_process	GO:0046903	secretion	"The controlled release of a substance by a cell or a tissue." [GOC:ai]	OMA
NV2t021881001.1	biological_process	GO:0050482	arachidonic acid secretion	"The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai]	InterPro
NV2t021881001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t021881001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t021881001.1	molecular_function	GO:0047498	calcium-dependent phospholipase A2 activity	"Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4]	PANTHER
NV2t021884001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t021886001.1	biological_process	GO:0045930	negative regulation of mitotic cell cycle	"Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t021887001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t021887001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t021887001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021887001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021887001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	OMA
NV2t021887001.1	molecular_function	GO:0047940	glucuronokinase activity	"Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H+." [EC:2.7.1.43, RHEA:17005]	PANTHER
NV2t021888001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t021888001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t021888001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t021888001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t021888001.1	biological_process	GO:0046580	negative regulation of Ras protein signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	OMA
NV2t021888001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t021888002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t021888002.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t021890001.1	molecular_function	GO:0019202	amino acid kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]	OMA
NV2t021890001.1	molecular_function	GO:0019202	amino acid kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]	PANTHER
NV2t021891001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t021891001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t021892001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021892001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021892001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021892002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021892002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021893001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021893001.1	molecular_function	GO:0051033	RNA transmembrane transporter activity	"Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]	PANTHER
NV2t021893002.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t021893002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021893002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t021893002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t021893002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t021893002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t021893002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t021894001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t021894001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t021894001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t021894001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t021894001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t021894001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t021894001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t021894001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t021896001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t021898001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t021898001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021902001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021902010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021903001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t021903001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021903001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021903002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021903002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021903003.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021903003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021903004.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021903004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021904001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021904001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021905001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t021912001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t021915001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021918008.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t021924001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021924002.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t021926001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021926001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021927001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021927001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t021927001.1	molecular_function	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	OMA
NV2t021929001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t021929001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t021929001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	OMA
NV2t021929001.1	molecular_function	GO:0008239	dipeptidyl-peptidase activity	"Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]	PANTHER
NV2t021929001.1	molecular_function	GO:0070008	serine-type exopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]	InterPro
NV2t021930001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t021930001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t021930002.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t021930002.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	PANTHER
NV2t021931001.1	cellular_component	GO:0070761	pre-snoRNP complex	"A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390]	PANTHER
NV2t021931002.1	cellular_component	GO:0070761	pre-snoRNP complex	"A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390]	PANTHER
NV2t021932001.1	biological_process	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	OMA
NV2t021932001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t021932001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021932001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t021932001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t021932002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021932002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t021932003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021932003.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t021932004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021932004.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t021932005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021932005.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t021933001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t021933001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t021934001.1	biological_process	GO:0006694	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	OMA
NV2t021934001.1	biological_process	GO:0008210	estrogen metabolic process	"The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]	OMA
NV2t021934001.1	biological_process	GO:0042446	hormone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t021934001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021934001.1	molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	"Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]	OMA
NV2t021934001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t021934001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t021935001.1	biological_process	GO:0016236	macroautophagy	"The autophagic process that proceeds via the formation of an autophagosome." [PMID:24366339]	PANTHER
NV2t021937001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t021937001.1	molecular_function	GO:0015386	potassium:proton antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-]	OMA
NV2t021937002.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t021938001.1	biological_process	GO:0034080	CENP-A containing chromatin assembly	"The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403, PMID:35422390]	PANTHER
NV2t021938001.1	biological_process	GO:0034508	centromere complex assembly	"The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]	InterPro
NV2t021938001.1	biological_process	GO:0034508	centromere complex assembly	"The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]	OMA
NV2t021938001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t021940001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t021940001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t021940001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021940001.1	molecular_function	GO:0005267	potassium channel activity	"Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t021941001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t021941001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t021941001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t021941001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t021941001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t021941001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t021941001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t021942001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t021942001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t021943001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t021943001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021943002.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t021943002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021946001.1	biological_process	GO:0006747	FAD biosynthetic process	"The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide." [GOC:ai, PMID:20822113]	PANTHER
NV2t021946001.1	biological_process	GO:0009165	nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]	OMA
NV2t021946001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t021946001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t021946001.1	molecular_function	GO:0070566	adenylyltransferase activity	"Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]	OMA
NV2t021947001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021947001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021948001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t021949001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t021950001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021950001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021950001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021950001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021951001.1	biological_process	GO:0006535	cysteine biosynthetic process from serine	"The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]	InterPro
NV2t021951001.1	biological_process	GO:0019343	cysteine biosynthetic process via cystathionine	"The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators]	InterPro
NV2t021951001.1	biological_process	GO:0019344	cysteine biosynthetic process	"The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]	PANTHER
NV2t021951002.1	biological_process	GO:0000097	sulfur amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]	OMA
NV2t021951002.1	biological_process	GO:0006535	cysteine biosynthetic process from serine	"The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]	InterPro
NV2t021951002.1	biological_process	GO:0006563	L-serine metabolic process	"The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg]	OMA
NV2t021951002.1	biological_process	GO:0009070	serine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]	OMA
NV2t021951002.1	biological_process	GO:0019343	cysteine biosynthetic process via cystathionine	"The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators]	InterPro
NV2t021951002.1	biological_process	GO:0019344	cysteine biosynthetic process	"The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]	PANTHER
NV2t021951002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021951002.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t021953001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021953001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t021954001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t021954001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t021954001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t021954001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t021954001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t021954001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t021954001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t021955001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t021955001.1	biological_process	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	PANTHER
NV2t021955002.1	biological_process	GO:0002683	negative regulation of immune system process	"Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t021955002.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t021955002.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t021955002.1	biological_process	GO:0010720	positive regulation of cell development	"Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t021955002.1	biological_process	GO:0010721	negative regulation of cell development	"Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t021955002.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t021955002.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	OMA
NV2t021955002.1	biological_process	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	OMA
NV2t021955002.1	biological_process	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	PANTHER
NV2t021955002.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t021955002.1	biological_process	GO:0051241	negative regulation of multicellular organismal process	"Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t021955002.1	biological_process	GO:1903706	regulation of hemopoiesis	"Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761]	OMA
NV2t021955002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021955002.1	molecular_function	GO:0004445	inositol-polyphosphate 5-phosphatase activity	"Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]	OMA
NV2t021955002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021956001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t021956001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021956001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021956001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021957001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t021957001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t021959001.1	biological_process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	"The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway." [PMID:8396717]	OMA
NV2t021959001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021959001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t021959001.1	biological_process	GO:0031323	regulation of cellular metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]	OMA
NV2t021959001.1	biological_process	GO:0031401	positive regulation of protein modification process	"Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]	OMA
NV2t021959001.1	biological_process	GO:0031623	receptor internalization	"A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]	OMA
NV2t021959001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t021959001.1	biological_process	GO:0045746	negative regulation of Notch signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t021959001.1	biological_process	GO:0048260	positive regulation of receptor-mediated endocytosis	"Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]	OMA
NV2t021959001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t021959001.1	biological_process	GO:0065009	regulation of molecular function	"Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]	OMA
NV2t021959001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	OMA
NV2t021959001.1	biological_process	GO:1903320	regulation of protein modification by small protein conjugation or removal	"Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t021959001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t021959001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021959001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021959001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t021959001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t021960001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t021961001.1	biological_process	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	PANTHER
NV2t021965001.1	biological_process	GO:0035332	positive regulation of hippo signaling	"Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]	OMA
NV2t021965001.1	biological_process	GO:0035332	positive regulation of hippo signaling	"Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t021965001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021965001.1	cellular_component	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]	OMA
NV2t021965001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021965002.1	biological_process	GO:0035332	positive regulation of hippo signaling	"Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t021965002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021965003.1	biological_process	GO:0035332	positive regulation of hippo signaling	"Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t021965003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021965004.1	biological_process	GO:0035332	positive regulation of hippo signaling	"Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t021965004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021965005.1	biological_process	GO:0035332	positive regulation of hippo signaling	"Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf]	PANTHER
NV2t021965005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021966001.1	biological_process	GO:0006595	polyamine metabolic process	"The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	OMA
NV2t021966001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t021966001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t021966001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t021966001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t021966002.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t021969001.1	biological_process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	"An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process." [GOC:BHF, GOC:mah, GOC:signaling]	PANTHER
NV2t021969001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021969001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021969001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021971001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t021971001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t021972001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t021972001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t021972001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t021972001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t021972001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021972001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t021973001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021973001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t021975001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021975001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t021975001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t021976001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t021976001.1	biological_process	GO:0036065	fucosylation	"The covalent attachment of a fucosyl group to an acceptor molecule." [GOC:sart, PMID:19948734]	OMA
NV2t021976001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021976001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021976001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	OMA
NV2t021976001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t021976002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021976002.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t021976003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021976003.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t021977001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t021977001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t021977001.1	biological_process	GO:1901800	positive regulation of proteasomal protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198]	OMA
NV2t021977001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t021977001.1	cellular_component	GO:0008540	proteasome regulatory particle, base subcomplex	"The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb]	OMA
NV2t021977001.1	cellular_component	GO:0031981	nuclear lumen	"The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]	OMA
NV2t021977001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021977001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021977001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t021977002.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t021977002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t021979001.1	biological_process	GO:0048678	response to axon injury	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]	OMA
NV2t021979001.1	biological_process	GO:0048678	response to axon injury	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]	PANTHER
NV2t021979001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021979001.1	cellular_component	GO:0032433	filopodium tip	"The end of a filopodium distal to the body of the cell." [GOC:mah]	OMA
NV2t021979001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t021979001.1	cellular_component	GO:0043226	organelle	"Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t021979001.1	cellular_component	GO:0098862	cluster of actin-based cell projections	"A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos]	OMA
NV2t021979001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t021980001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t021980001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t021980001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t021980001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t021980002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t021980002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	PANTHER
NV2t021981001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021981001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t021981001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021981001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021981002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t021981002.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t021981002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t021981002.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t021981002.1	cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]	OMA
NV2t021981002.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t021981002.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t021981002.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t021981002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021981002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t021981002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t021982001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t021982001.1	cellular_component	GO:1902554	serine/threonine protein kinase complex	"A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223]	OMA
NV2t021982001.1	molecular_function	GO:0034237	protein kinase A regulatory subunit binding	"Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah]	OMA
NV2t021982001.1	molecular_function	GO:0034237	protein kinase A regulatory subunit binding	"Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah]	PANTHER
NV2t021983001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t021983001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	OMA
NV2t021983001.1	biological_process	GO:0043001	Golgi to plasma membrane protein transport	"The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]	PANTHER
NV2t021983001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t021984001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t021984001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021984002.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t021984002.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t021984002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021984002.1	molecular_function	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	"Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]	OMA
NV2t021984002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021984002.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t021985001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t021985001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t021985001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t021986001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t021987001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	InterPro
NV2t021987001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	OMA
NV2t021987001.1	cellular_component	GO:1990726	Lsm1-7-Pat1 complex	"A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]	PANTHER
NV2t021987001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t021988001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	OMA
NV2t021988001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t021988001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t021988001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t021988001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t021990001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t021990001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t021994001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021994001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021994002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021994002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021994003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021994003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021994004.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021994004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021994005.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t021994005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021994006.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t021994006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t021998001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t021998001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t021999001.1	biological_process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	"Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah]	InterPro
NV2t021999001.1	biological_process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	"Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah]	OMA
NV2t021999001.1	molecular_function	GO:0004865	protein serine/threonine phosphatase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb]	OMA
NV2t022001001.1	biological_process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	"A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083]	OMA
NV2t022001001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t022001001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t022001001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022001001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	OMA
NV2t022001001.1	molecular_function	GO:0015095	magnesium ion transmembrane transporter activity	"Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf]	OMA
NV2t022001001.1	molecular_function	GO:0032977	membrane insertase activity	"Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]	OMA
NV2t022003001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t022003001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	InterPro
NV2t022003001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t022004001.1	biological_process	GO:0009132	nucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022004001.1	biological_process	GO:1901292	nucleoside phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie]	OMA
NV2t022004001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022004001.1	molecular_function	GO:0004382	GDP phosphatase activity	"Catalysis of the reaction: GDP + H2O = GMP + phosphate." [PMID:2989286, RHEA:22156]	OMA
NV2t022004001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022004001.1	molecular_function	GO:0045134	UDP phosphatase activity	"Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876]	OMA
NV2t022006001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	InterPro
NV2t022006001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t022006001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022006001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t022006001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t022013001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	OMA
NV2t022013001.1	biological_process	GO:0006465	signal peptide processing	"The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t022013001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t022013001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022013001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022014001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t022015001.1	biological_process	GO:1905475	regulation of protein localization to membrane	"Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	PANTHER
NV2t022015001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	InterPro
NV2t022018001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t022018001.1	biological_process	GO:1905475	regulation of protein localization to membrane	"Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690]	PANTHER
NV2t022018001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	InterPro
NV2t022018001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t022019001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t022019001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t022019001.1	molecular_function	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3.-, GOC:mah]	OMA
NV2t022019001.1	molecular_function	GO:0047750	cholestenol delta-isomerase activity	"Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [RHEA:15281]	InterPro
NV2t022020001.1	biological_process	GO:0000731	DNA synthesis involved in DNA repair	"Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855]	OMA
NV2t022020001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t022020001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t022020001.1	biological_process	GO:0070914	UV-damage excision repair	"A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]	OMA
NV2t022020001.1	biological_process	GO:1904161	DNA synthesis involved in UV-damage excision repair	"Any DNA synthesis that is involved in UV-damage excision repair." [GO_REF:0000060, GOC:TermGenie, PMID:10704216]	PANTHER
NV2t022020001.1	cellular_component	GO:0043625	delta DNA polymerase complex	"A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]	InterPro
NV2t022020001.1	cellular_component	GO:0043625	delta DNA polymerase complex	"A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]	OMA
NV2t022020001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t022020002.1	biological_process	GO:1904161	DNA synthesis involved in UV-damage excision repair	"Any DNA synthesis that is involved in UV-damage excision repair." [GO_REF:0000060, GOC:TermGenie, PMID:10704216]	PANTHER
NV2t022020002.1	cellular_component	GO:0043625	delta DNA polymerase complex	"A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]	InterPro
NV2t022021001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022021001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022022001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t022022001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022023001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022023001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022023001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022024001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	InterPro
NV2t022024001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t022024001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022024001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t022024002.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	InterPro
NV2t022025001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t022025001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t022025001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t022025001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	OMA
NV2t022025001.1	cellular_component	GO:0015934	large ribosomal subunit	"The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732]	PANTHER
NV2t022025001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t022025001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t022026001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022026002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022030001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t022030001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022033002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022033002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022033002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022034001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t022034001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t022034001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t022034001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t022034001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t022034001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t022036001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	InterPro
NV2t022036001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t022036001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t022037001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022037001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t022037001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t022037001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t022037001.1	cellular_component	GO:0070847	core mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t022037001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t022039001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	PANTHER
NV2t022039001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022040001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022041001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t022041002.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	InterPro
NV2t022042001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022042001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022042001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022042001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022044001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t022044001.1	biological_process	GO:0006282	regulation of DNA repair	"Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]	InterPro
NV2t022044001.1	biological_process	GO:0006282	regulation of DNA repair	"Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]	OMA
NV2t022044001.1	biological_process	GO:0009225	nucleotide-sugar metabolic process	"The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]	OMA
NV2t022044001.1	biological_process	GO:0031056	obsolete regulation of histone modification	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]	OMA
NV2t022044001.1	biological_process	GO:0043170	macromolecule metabolic process	"The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah]	OMA
NV2t022044001.1	biological_process	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	OMA
NV2t022044001.1	biological_process	GO:1990966	ATP generation from poly-ADP-D-ribose	"The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming." [PMID:27257257]	PANTHER
NV2t022044001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022044001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022044001.1	molecular_function	GO:0004649	poly(ADP-ribose) glycohydrolase activity	"Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]	OMA
NV2t022046001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022046001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t022047001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t022047001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	OMA
NV2t022047001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t022048001.1	biological_process	GO:0045116	protein neddylation	"Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]	OMA
NV2t022048001.1	biological_process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	"Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb]	OMA
NV2t022048001.1	biological_process	GO:2000436	positive regulation of protein neddylation	"Any process that activates or increases the frequency, rate or extent of protein neddylation." [GOC:obol]	OMA
NV2t022048001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t022048001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022048001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022048001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022048001.1	molecular_function	GO:0031624	ubiquitin conjugating enzyme binding	"Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]	OMA
NV2t022048001.1	molecular_function	GO:0032182	ubiquitin-like protein binding	"Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah]	OMA
NV2t022048001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	OMA
NV2t022048001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t022050001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022050001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t022052001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022052001.1	molecular_function	GO:0017128	phospholipid scramblase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]	InterPro
NV2t022052001.1	molecular_function	GO:0017128	phospholipid scramblase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]	OMA
NV2t022054001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t022054001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022054001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t022054001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022054001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022056001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t022056001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022056001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022056001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022056001.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t022057001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022057001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022058001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t022058001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022058001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022058001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022058001.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t022058002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022058002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022067001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022067001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022071001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t022071001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022071001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022071002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t022071002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022071002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022071003.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t022071003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022071003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022071004.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t022071004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022071004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022071005.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t022071005.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022071005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022071006.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t022071006.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022071006.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022075001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t022075001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	InterPro
NV2t022076001.1	biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t022076002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022077001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022077001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022079001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022079001.1	biological_process	GO:0071363	cellular response to growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]	PANTHER
NV2t022079001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022080001.1	biological_process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	"The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t022081001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t022081001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022083001.1	biological_process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	InterPro
NV2t022083001.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t022083002.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t022083002.1	biological_process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	InterPro
NV2t022083002.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t022083002.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t022083002.1	biological_process	GO:0070972	protein localization to endoplasmic reticulum	"A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]	OMA
NV2t022083002.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t022083002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t022083002.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t022083002.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t022083002.1	cellular_component	GO:0098796	membrane protein complex	"Any protein complex that is part of a membrane." [GOC:dos]	OMA
NV2t022083002.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t022083002.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t022083002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t022083002.1	molecular_function	GO:0043021	ribonucleoprotein complex binding	"Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]	OMA
NV2t022083003.1	biological_process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	InterPro
NV2t022083003.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t022083003.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t022083004.1	biological_process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	InterPro
NV2t022083004.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t022083004.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t022083004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022083005.1	biological_process	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	"The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]	InterPro
NV2t022083005.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t022083005.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t022083005.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022084001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022085001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	OMA
NV2t022085001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022085001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t022085001.1	molecular_function	GO:0005452	solute:inorganic anion antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out)." [GOC:mah]	OMA
NV2t022085001.1	molecular_function	GO:0015605	organophosphate ester transmembrane transporter activity	"Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc]	OMA
NV2t022085001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022085001.1	molecular_function	GO:1901505	carbohydrate derivative transmembrane transporter activity	"Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t022087001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t022088001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	PANTHER
NV2t022088002.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	PANTHER
NV2t022088003.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	PANTHER
NV2t022088004.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t022088004.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	PANTHER
NV2t022088005.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	PANTHER
NV2t022089001.1	biological_process	GO:0006509	membrane protein ectodomain proteolysis	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]	OMA
NV2t022089001.1	biological_process	GO:0007220	Notch receptor processing	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]	OMA
NV2t022089001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t022089001.1	biological_process	GO:0010950	positive regulation of endopeptidase activity	"Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t022089001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t022089001.1	biological_process	GO:0031293	membrane protein intracellular domain proteolysis	"The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018]	OMA
NV2t022089001.1	biological_process	GO:0034205	amyloid-beta formation	"The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP)." [GOC:mah]	OMA
NV2t022089001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t022089001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022089001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t022089001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t022089001.1	cellular_component	GO:0070765	gamma-secretase complex	"A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein." [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437]	OMA
NV2t022089001.1	cellular_component	GO:0070765	gamma-secretase complex	"A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein." [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437]	PANTHER
NV2t022091001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t022101001.1	molecular_function	GO:0003839	gamma-glutamylcyclotransferase activity	"Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [PMID:18515354]	PANTHER
NV2t022101001.1	molecular_function	GO:0016842	amidine-lyase activity	"Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]	OMA
NV2t022104001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022109001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t022109001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022109001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022110001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022110001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t022111001.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	PANTHER
NV2t022112001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022112001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t022112001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022112002.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t022112002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022112002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t022112002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t022112002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t022112002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t022112002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022112002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022115001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t022115001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t022116001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022116001.1	molecular_function	GO:0043047	single-stranded telomeric DNA binding	"Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]	InterPro
NV2t022116001.1	molecular_function	GO:0098505	G-rich strand telomeric DNA binding	"Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150]	PANTHER
NV2t022117001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t022117001.1	biological_process	GO:0006821	chloride transport	"The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t022117001.1	biological_process	GO:0006884	cell volume homeostasis	"Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t022117001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	PANTHER
NV2t022117001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022117001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022117001.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t022117001.1	cellular_component	GO:0034715	pICln-Sm protein complex	"A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266]	InterPro
NV2t022117001.1	cellular_component	GO:0120114	Sm-like protein family complex	"A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles." [GOC:bhm, GOC:krc, PMID:19121818, PMID:27627834]	OMA
NV2t022118001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022118001.1	biological_process	GO:0015937	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	InterPro
NV2t022118001.1	biological_process	GO:0015937	coenzyme A biosynthetic process	"The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	PANTHER
NV2t022118001.1	biological_process	GO:0034030	ribonucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t022118001.1	biological_process	GO:0034033	purine nucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t022118001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022118001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022118001.1	molecular_function	GO:0004594	pantothenate kinase activity	"Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]	OMA
NV2t022118001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022120001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022120001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t022120001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t022120001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t022120001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t022120001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022120001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022121001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t022121001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022121001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022121001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022121001.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	InterPro
NV2t022121001.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	OMA
NV2t022125001.1	cellular_component	GO:0005740	mitochondrial envelope	"The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]	OMA
NV2t022125001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022125001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022125001.1	molecular_function	GO:0048039	ubiquinone binding	"Binding to ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jid, ISBN:0582227089]	PANTHER
NV2t022126001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022126001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022126001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022127001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022127001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t022129001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t022129001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022130001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t022131001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t022131001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022131001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022131001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022131001.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t022132001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022132001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022132001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t022132002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022132002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022136001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022136001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022136001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t022138001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	InterPro
NV2t022138001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t022140001.1	biological_process	GO:0006414	translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]	InterPro
NV2t022140001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t022140001.1	biological_process	GO:0070125	mitochondrial translational elongation	"The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]	PANTHER
NV2t022140001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022140001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	InterPro
NV2t022140001.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t022140001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t022140001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022140001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t022142001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022142001.1	biological_process	GO:0060964	regulation of miRNA-mediated gene silencing	"A process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs)." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604]	InterPro
NV2t022143001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t022143001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022143001.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	InterPro
NV2t022143001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t022145001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t022145001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022145001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022148001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022148001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t022153001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022153001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022153002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022155001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t022155002.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t022156001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	OMA
NV2t022156001.1	biological_process	GO:0009259	ribonucleotide metabolic process	"The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022156001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t022156001.1	cellular_component	GO:0032299	ribonuclease H2 complex	"A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815]	InterPro
NV2t022156001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t022156001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t022162001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022164001.1	biological_process	GO:0006304	DNA modification	"The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]	OMA
NV2t022164001.1	biological_process	GO:0009307	DNA restriction-modification system	"A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme." [GOC:jl, UniProtKB-KW:KW-0680]	InterPro
NV2t022164001.1	biological_process	GO:0098542	defense response to other organism	"Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos]	OMA
NV2t022164001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t022164001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022164001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t022164001.1	molecular_function	GO:0004519	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t022165001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t022165001.1	biological_process	GO:0006497	protein lipidation	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]	OMA
NV2t022165001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t022165001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t022165001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t022165001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t022165001.1	biological_process	GO:0018410	C-terminal protein amino acid modification	"The alteration of the C-terminal amino acid residue in a protein." [GOC:mah]	OMA
NV2t022165001.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t022165001.1	biological_process	GO:0032774	RNA biosynthetic process	"The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH]	OMA
NV2t022165001.1	biological_process	GO:0061912	obsolete selective autophagy	"OBSOLETE. The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490]	OMA
NV2t022165001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	OMA
NV2t022165001.1	cellular_component	GO:0000421	autophagosome membrane	"The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete]	PANTHER
NV2t022165001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t022165001.1	cellular_component	GO:0036020	endolysosome membrane	"The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]	OMA
NV2t022165001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t022165001.1	cellular_component	GO:0044232	organelle membrane contact site	"A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880]	OMA
NV2t022165001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t022165001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022165001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t022165001.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	OMA
NV2t022167001.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022167002.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022167003.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022167004.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022167005.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022167006.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022167007.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t022167007.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022167007.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022167008.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022167009.1	molecular_function	GO:0045296	cadherin binding	"Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]	PANTHER
NV2t022168001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t022168001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t022168001.1	biological_process	GO:0016574	obsolete histone ubiquitination	"OBSOLETE. The modification of histones by addition of ubiquitin groups." [GOC:ai]	OMA
NV2t022168001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t022168001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t022168001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t022168001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t022168001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t022168001.1	biological_process	GO:0048869	cellular developmental process	"A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t022168001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t022168001.1	biological_process	GO:0070914	UV-damage excision repair	"A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]	OMA
NV2t022168001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022168001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022168001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t022168001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t022168001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t022168001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t022168001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t022168001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t022170001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022170001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022170001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022170001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022170001.1	molecular_function	GO:0008241	peptidyl-dipeptidase activity	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]	OMA
NV2t022171001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022173001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t022173001.1	biological_process	GO:0007423	sensory organ development	"The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]	OMA
NV2t022173001.1	biological_process	GO:0007605	sensory perception of sound	"The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]	OMA
NV2t022173001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t022173001.1	biological_process	GO:0030048	actin filament-based movement	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]	OMA
NV2t022173001.1	biological_process	GO:0035315	hair cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf]	OMA
NV2t022173001.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	OMA
NV2t022173001.1	biological_process	GO:0120036	plasma membrane bounded cell projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc]	OMA
NV2t022173001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022173001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t022173001.1	cellular_component	GO:0005902	microvillus	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]	OMA
NV2t022173001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t022173001.1	cellular_component	GO:0016461	unconventional myosin complex	"A portmanteau term for myosins other than myosin II." [GOC:ma]	OMA
NV2t022173001.1	molecular_function	GO:0000146	microfilament motor activity	"A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]	OMA
NV2t022173001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022173001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022173001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t022173002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t022173002.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t022173002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022173003.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t022173003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022174001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022174001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022174001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022174001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022177001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022177001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022177001.1	molecular_function	GO:0005055	laminin receptor activity	"Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671]	OMA
NV2t022177002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022177003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022177004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022177005.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022177006.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022177007.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022177008.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022179001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022179001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022179001.1	molecular_function	GO:0005055	laminin receptor activity	"Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671]	OMA
NV2t022180001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t022180001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t022180001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t022181001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022181001.1	biological_process	GO:0072344	rescue of stalled ribosome	"A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543]	OMA
NV2t022181001.1	biological_process	GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411]	OMA
NV2t022181001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t022181001.1	cellular_component	GO:1990391	DNA repair complex	"A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]	OMA
NV2t022181001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022181001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	InterPro
NV2t022181001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t022181001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	PANTHER
NV2t022182001.1	biological_process	GO:0006072	glycerol-3-phosphate metabolic process	"The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t022182001.1	biological_process	GO:0006641	triglyceride metabolic process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]	OMA
NV2t022182001.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	OMA
NV2t022182001.1	biological_process	GO:0019400	alditol metabolic process	"The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]	OMA
NV2t022182001.1	biological_process	GO:0046167	glycerol-3-phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	OMA
NV2t022182001.1	biological_process	GO:0046167	glycerol-3-phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	PANTHER
NV2t022182001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022182001.1	molecular_function	GO:0004370	glycerol kinase activity	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+." [EC:2.7.1.30, RHEA:21644]	OMA
NV2t022182001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t022182001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	InterPro
NV2t022185001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022186001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022186001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022186001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022187001.1	biological_process	GO:0009914	hormone transport	"The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]	OMA
NV2t022187001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022187001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022187001.1	molecular_function	GO:0015173	aromatic amino acid transmembrane transporter activity	"Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022187001.1	molecular_function	GO:0015291	secondary active transmembrane transporter activity	"Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]	OMA
NV2t022187001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022188001.1	biological_process	GO:0003006	developmental process involved in reproduction	"A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]	OMA
NV2t022188001.1	biological_process	GO:0006308	DNA catabolic process	"The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022188001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t022188001.1	biological_process	GO:0006950	response to stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t022188001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t022188001.1	biological_process	GO:0016441	post-transcriptional gene silencing	"The inactivation of gene expression that occurs after transcription." [GOC:mah, PMID:15020054]	OMA
NV2t022188001.1	biological_process	GO:0022411	cellular component disassembly	"A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]	OMA
NV2t022188001.1	biological_process	GO:0030422	siRNA processing	"A process leading to the generation of a functional small interfering RNA (siRNA). Includes the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides. May also include amplification of the siRNA by RNA-directed RNA polymerase." [GOC:mah, PMID:11524674, PMID:19239886, PMID:20687832]	OMA
NV2t022188001.1	biological_process	GO:0031054	pre-miRNA processing	"A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]	InterPro
NV2t022188001.1	biological_process	GO:0031054	pre-miRNA processing	"A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]	OMA
NV2t022188001.1	biological_process	GO:0048522	positive regulation of cellular process	"Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t022188001.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t022188001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t022188001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t022188001.1	biological_process	GO:0051252	regulation of RNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	OMA
NV2t022188001.1	biological_process	GO:0070922	RISC complex assembly	"The process in which a single-stranded small RNA is incorporated within the RNA-initiated silencing complex (RISC). The assembly includes the maturation of the small RNA, the stabilization of the complex by accessory proteins of the RISC complex, duplex separation and the release of the second strand, forming a base-pairing completent complex that mediates gene silencing by small RNA." [PMID:14512631, PMID:14744438, PMID:19239886, PMID:22233755, PMID:27184117]	OMA
NV2t022188001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	PANTHER
NV2t022188001.1	biological_process	GO:0097194	execution phase of apoptosis	"A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595]	OMA
NV2t022188001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022188001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022188001.1	cellular_component	GO:0016442	RISC complex	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]	OMA
NV2t022188001.1	cellular_component	GO:0070578	RISC-loading complex	"A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]	OMA
NV2t022188001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t022188001.1	molecular_function	GO:0004525	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	OMA
NV2t022188001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022188001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022188001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022188001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022188001.1	molecular_function	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t022188001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	InterPro
NV2t022188001.1	molecular_function	GO:0070883	pre-miRNA binding	"Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]	OMA
NV2t022188002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t022188002.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	PANTHER
NV2t022188002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022188002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022188002.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	InterPro
NV2t022188003.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t022188003.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	PANTHER
NV2t022188003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022188003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022188003.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	InterPro
NV2t022188004.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t022188004.1	biological_process	GO:0031054	pre-miRNA processing	"A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]	InterPro
NV2t022188004.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	PANTHER
NV2t022188004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022188004.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	InterPro
NV2t022189001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022189001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022189001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t022190001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022190001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t022191001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t022191001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t022191002.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t022191002.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t022192001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022192001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022192001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022192002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022192002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022192002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022192003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022192003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022192003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022192004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022192004.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022192004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022192005.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022192005.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022192005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022192006.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022192006.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022192006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022192007.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022192007.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022192007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022192008.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022192008.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022192008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022195001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022195001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022195001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022195002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022195002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t022198001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t022198001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022198001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t022198001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t022198001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022198001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t022199001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022200001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t022200001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022200001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t022200001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t022200001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022200001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t022200001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t022202001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t022202001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022202001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t022202001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t022202001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022202001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t022202001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t022205001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	PANTHER
NV2t022205001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022205002.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	PANTHER
NV2t022205002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022205003.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	PANTHER
NV2t022205003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022205004.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	PANTHER
NV2t022205004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022205005.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	PANTHER
NV2t022205005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022205006.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	PANTHER
NV2t022205006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022205006.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t022207001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t022207001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022207001.1	molecular_function	GO:0008139	nuclear localization sequence binding	"Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai]	OMA
NV2t022207001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t022207001.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t022207002.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t022207003.1	molecular_function	GO:0061608	nuclear import signal receptor activity	"Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]	PANTHER
NV2t022216001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t022217001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t022217001.1	molecular_function	GO:0033819	lipoyl(octanoyl) transferase activity	"Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]." [RHEA:17665]	InterPro
NV2t022217001.1	molecular_function	GO:0033819	lipoyl(octanoyl) transferase activity	"Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]." [RHEA:17665]	PANTHER
NV2t022218001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t022218001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022218001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022218001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022218001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	PANTHER
NV2t022218001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022218001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t022219001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t022219001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t022219001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	OMA
NV2t022219001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t022220001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t022220001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022220001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t022221001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t022222001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t022222001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t022222002.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t022222002.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t022223001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022224001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t022224001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022224001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022224001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022224002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022224002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022227001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022227001.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	OMA
NV2t022227001.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	PANTHER
NV2t022227002.1	cellular_component	GO:0070822	Sin3-type complex	"Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]	PANTHER
NV2t022228001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022228001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022228001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t022230001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t022230001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022230001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t022230001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t022230001.1	molecular_function	GO:0035250	UDP-galactosyltransferase activity	"Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195]	PANTHER
NV2t022231001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t022231001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022231001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022231001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022233001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t022233001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022233001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t022233001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t022233001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022233001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t022233001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t022234001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t022234001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022234001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022234001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t022236001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t022236001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022236001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022238001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t022238001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t022239001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t022239002.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t022240001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t022240001.1	biological_process	GO:0030336	negative regulation of cell migration	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t022240001.1	biological_process	GO:0032486	Rap protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rap subfamily relays a signal." [GOC:mah]	OMA
NV2t022240001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022240001.1	molecular_function	GO:0003925	G protein activity	"A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015]	OMA
NV2t022240001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022240001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t022240001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t022241001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t022241001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	InterPro
NV2t022242001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022242002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022242003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022248001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022255001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022256001.1	biological_process	GO:0019262	N-acetylneuraminate catabolic process	"The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]	PANTHER
NV2t022256001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t022256001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	OMA
NV2t022258001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022258001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022258001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022258002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022258002.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022258003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022258003.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022259001.1	biological_process	GO:0051645	Golgi localization	"Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t022259002.1	biological_process	GO:0051645	Golgi localization	"Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	PANTHER
NV2t022260001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022260001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t022260001.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t022260001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t022260001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t022260001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022260001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022260002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022260002.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t022260003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022260003.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t022260003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022260004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022260004.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t022260004.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t022260004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022260005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022260005.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t022260005.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t022260005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022260006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022260006.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t022260006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022260007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022260007.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t022260007.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t022260007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022260008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022260008.1	biological_process	GO:0043408	regulation of MAPK cascade	"Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]	PANTHER
NV2t022260008.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t022260008.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022263001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022265001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022265001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022265001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t022265002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022265002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022266001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022266001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t022266001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022268001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t022268001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t022268001.1	cellular_component	GO:0000159	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	OMA
NV2t022268001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022268001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	OMA
NV2t022268001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022268001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t022268001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022268002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022268002.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022268003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022268003.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022268004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022268004.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022268005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022268005.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022268006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022268006.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	PANTHER
NV2t022269001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022270001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022271001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t022271001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022271001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t022271002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t022271002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022271002.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t022271003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t022271003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022271003.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t022274001.1	biological_process	GO:0051503	adenine nucleotide transport	"The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t022274001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022274001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t022274001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022274001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022276001.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	InterPro
NV2t022276001.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	PANTHER
NV2t022276001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022276001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022276001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022276002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t022276002.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	InterPro
NV2t022276002.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	OMA
NV2t022276002.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	PANTHER
NV2t022276002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022276002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022276002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022276002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022276003.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	InterPro
NV2t022276003.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	PANTHER
NV2t022276003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022276003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022276003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022277001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t022277001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t022277001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t022278001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022278001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022278001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t022279001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022279001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022280001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t022280001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t022280001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t022280001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t022280001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t022280001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t022280001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t022280001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t022280002.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t022280002.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t022281001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t022281001.1	biological_process	GO:0019433	triglyceride catabolic process	"The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732]	OMA
NV2t022281001.1	biological_process	GO:0019433	triglyceride catabolic process	"The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t022281001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t022281001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022281001.1	molecular_function	GO:0004771	sterol esterase activity	"Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]	OMA
NV2t022281001.1	molecular_function	GO:0004806	triglyceride lipase activity	"Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3]	OMA
NV2t022281001.1	molecular_function	GO:0016298	lipase activity	"Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah, ISBN:0198506732]	InterPro
NV2t022281001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022282001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022282001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022282001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022283001.1	biological_process	GO:0010888	negative regulation of lipid storage	"Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t022283001.1	biological_process	GO:0010893	positive regulation of steroid biosynthetic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb]	OMA
NV2t022283001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t022283001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t022283001.1	biological_process	GO:0030301	cholesterol transport	"The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]	OMA
NV2t022283001.1	biological_process	GO:0032374	regulation of cholesterol transport	"Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t022283001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t022283001.1	biological_process	GO:0033993	response to lipid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]	OMA
NV2t022283001.1	biological_process	GO:0034250	positive regulation of amide metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]	OMA
NV2t022283001.1	biological_process	GO:0042632	cholesterol homeostasis	"Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]	OMA
NV2t022283001.1	biological_process	GO:0042987	amyloid precursor protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]	OMA
NV2t022283001.1	biological_process	GO:0043933	protein-containing complex organization	"Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah]	OMA
NV2t022283001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t022283001.1	biological_process	GO:0050714	positive regulation of protein secretion	"Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]	OMA
NV2t022283001.1	biological_process	GO:0051247	positive regulation of protein metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]	OMA
NV2t022283001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t022283001.1	biological_process	GO:0055091	phospholipid homeostasis	"Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t022283001.1	biological_process	GO:0062013	positive regulation of small molecule metabolic process	"Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw]	OMA
NV2t022283001.1	biological_process	GO:1901264	carbohydrate derivative transport	"The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie]	OMA
NV2t022283001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t022283001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022283001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t022283001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t022283001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022283001.1	molecular_function	GO:0008525	phosphatidylcholine transporter activity	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]	OMA
NV2t022283001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022283001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t022283001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t022283001.1	molecular_function	GO:0120013	lipid transfer activity	"Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t022283001.1	molecular_function	GO:0140303	intramembrane lipid transporter activity	"Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084]	OMA
NV2t022283001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t022283001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t022283001.1	molecular_function	GO:1901618	organic hydroxy compound transmembrane transporter activity	"Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t022283002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t022283002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022283002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t022283003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t022283003.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t022284001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022285001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022286001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t022286001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022290001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022291001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022293001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t022293001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022293002.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t022293002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022293003.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t022293003.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t022293003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022293003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022294001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022295001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t022295001.1	molecular_function	GO:0031210	phosphatidylcholine binding	"Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t022296001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t022296001.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t022296001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t022296001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t022296001.1	biological_process	GO:1901658	glycosyl compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t022296001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t022296001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t022298001.1	biological_process	GO:0046579	positive regulation of Ras protein signal transduction	"Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	PANTHER
NV2t022299001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022300001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	PANTHER
NV2t022301001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t022301001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t022301001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t022301001.1	biological_process	GO:1902969	mitotic DNA replication	"Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie]	OMA
NV2t022301001.1	biological_process	GO:1902975	mitotic DNA replication initiation	"Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]	InterPro
NV2t022301001.1	biological_process	GO:1902975	mitotic DNA replication initiation	"Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie]	PANTHER
NV2t022301001.1	cellular_component	GO:0005658	alpha DNA polymerase:primase complex	"A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377]	OMA
NV2t022301001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022301001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022301001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t022301001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t022301001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	InterPro
NV2t022301001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t022301001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022301001.1	molecular_function	GO:0017076	purine nucleotide binding	"Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]	OMA
NV2t022301001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t022302002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022302002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022302002.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t022303001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022304001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	PANTHER
NV2t022304001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t022304001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t022304001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t022304001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t022305001.1	cellular_component	GO:0000782	telomere cap complex	"A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh]	OMA
NV2t022305001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t022305001.1	cellular_component	GO:1990879	CST complex	"A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19854130, PMID:22965356]	InterPro
NV2t022305001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t022309001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t022309001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022309001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t022310001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	OMA
NV2t022310001.1	biological_process	GO:0006767	water-soluble vitamin metabolic process	"The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl]	OMA
NV2t022310001.1	biological_process	GO:0033013	tetrapyrrole metabolic process	"The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah]	OMA
NV2t022310001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022310001.1	molecular_function	GO:0016722	oxidoreductase activity, acting on metal ions	"Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah]	OMA
NV2t022310001.1	molecular_function	GO:0032451	demethylase activity	"Catalysis of the removal of a methyl group from a substrate." [GOC:mah]	OMA
NV2t022310001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t022310001.1	molecular_function	GO:0043295	glutathione binding	"Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]	OMA
NV2t022310001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t022310001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t022312001.1	biological_process	GO:0051056	regulation of small GTPase mediated signal transduction	"Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]	InterPro
NV2t022312001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t022312001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022314001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022314001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022314005.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022314005.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022314006.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022314006.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022314007.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022314007.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022314008.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022314010.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022314010.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022314011.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022314011.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022317001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022317001.1	biological_process	GO:0046928	regulation of neurotransmitter secretion	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]	PANTHER
NV2t022317001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022317002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022317002.1	biological_process	GO:0046928	regulation of neurotransmitter secretion	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]	PANTHER
NV2t022317002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022317002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022317003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022318001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022318001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022318001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022318001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022318002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022318002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022318002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022318002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022318003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022318003.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022318004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022318004.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022319001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022321001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022321001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022321001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t022321001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	InterPro
NV2t022321001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t022321001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022321001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022323001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022323001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022323001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022324001.1	biological_process	GO:0002009	morphogenesis of an epithelium	"The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]	OMA
NV2t022324001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t022324001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022324001.1	biological_process	GO:0007369	gastrulation	"A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846]	OMA
NV2t022324001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t022324001.1	biological_process	GO:0007507	heart development	"The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948]	OMA
NV2t022324001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t022324001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t022324001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t022324001.1	biological_process	GO:0043067	regulation of programmed cell death	"Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]	OMA
NV2t022324001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022324001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t022324001.1	biological_process	GO:0048562	embryonic organ morphogenesis	"Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t022324001.1	biological_process	GO:0071396	cellular response to lipid	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]	OMA
NV2t022324001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t022324001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t022324001.1	cellular_component	GO:0044666	MLL3/4 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t022324001.1	cellular_component	GO:0044666	MLL3/4 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]	PANTHER
NV2t022324001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022324001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022324001.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	OMA
NV2t022324001.1	molecular_function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	"Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [GOC:sp, PMID:20622853]	OMA
NV2t022324001.1	molecular_function	GO:1990841	promoter-specific chromatin binding	"Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]	OMA
NV2t022324002.1	cellular_component	GO:0044666	MLL3/4 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]	PANTHER
NV2t022324002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022324003.1	cellular_component	GO:0044666	MLL3/4 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]	PANTHER
NV2t022324003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022325001.1	biological_process	GO:0006641	triglyceride metabolic process	"The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732]	OMA
NV2t022325001.1	biological_process	GO:0016310	phosphorylation	"The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]	OMA
NV2t022325001.1	biological_process	GO:0019400	alditol metabolic process	"The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]	OMA
NV2t022325001.1	biological_process	GO:0046167	glycerol-3-phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	OMA
NV2t022325001.1	biological_process	GO:0046167	glycerol-3-phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	PANTHER
NV2t022325001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022325001.1	molecular_function	GO:0004370	glycerol kinase activity	"Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+." [EC:2.7.1.30, RHEA:21644]	OMA
NV2t022325001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t022325002.1	biological_process	GO:0046167	glycerol-3-phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]	PANTHER
NV2t022325002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t022326001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022326001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022329001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t022330001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022330001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022330001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022330001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022330001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t022331001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022331001.1	biological_process	GO:0050435	amyloid-beta metabolic process	"The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai]	PANTHER
NV2t022331001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022338001.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t022338001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022338002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022338003.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t022338003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022338004.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t022338004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022339001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	OMA
NV2t022339001.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t022339001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022339001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022339001.1	molecular_function	GO:0017147	Wnt-protein binding	"Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]	OMA
NV2t022339001.1	molecular_function	GO:0042813	Wnt receptor activity	"Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]	OMA
NV2t022340001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t022340001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	PANTHER
NV2t022340001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022341001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t022341001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t022341001.1	molecular_function	GO:0017099	very-long-chain fatty acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [RHEA:19181]	PANTHER
NV2t022341001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t022341002.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t022341002.1	molecular_function	GO:0017099	very-long-chain fatty acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [RHEA:19181]	PANTHER
NV2t022341003.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t022341003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022341003.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t022341003.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	OMA
NV2t022341003.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t022341003.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t022341003.1	molecular_function	GO:0017099	very-long-chain fatty acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [RHEA:19181]	PANTHER
NV2t022341003.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t022341003.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t022341003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t022341003.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t022341003.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t022342001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t022347001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t022349001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022349001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t022350001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t022350001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	PANTHER
NV2t022353001.1	biological_process	GO:0007492	endoderm development	"The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb]	InterPro
NV2t022353001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022354001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t022354001.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	OMA
NV2t022354001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t022354001.1	cellular_component	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	OMA
NV2t022354001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	InterPro
NV2t022354001.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	OMA
NV2t022354001.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	InterPro
NV2t022354003.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	InterPro
NV2t022354003.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	InterPro
NV2t022354004.1	cellular_component	GO:0005876	spindle microtubule	"Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]	InterPro
NV2t022354004.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	InterPro
NV2t022355001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t022355002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t022355003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t022356001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t022356001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t022359001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022359001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t022361001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t022361001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t022362001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t022362001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t022362001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t022362002.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	PANTHER
NV2t022362002.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t022363001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022365001.1	biological_process	GO:0045039	protein insertion into mitochondrial inner membrane	"The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." [GOC:mcc, GOC:vw, PMID:18672008]	PANTHER
NV2t022365001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022366001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t022366001.1	biological_process	GO:0080009	obsolete mRNA methylation	"OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]	InterPro
NV2t022366001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022370001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022370001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022370001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022370001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022370001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022370001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t022371001.1	biological_process	GO:0007602	phototransduction	"The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]	OMA
NV2t022371001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	OMA
NV2t022371001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t022371001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022371001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022371001.1	molecular_function	GO:0008020	G protein-coupled photoreceptor activity	"Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732]	OMA
NV2t022373001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t022373001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t022373001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t022373001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	PANTHER
NV2t022375001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022375001.1	molecular_function	GO:0008083	growth factor activity	"The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]	OMA
NV2t022376001.1	biological_process	GO:0006309	apoptotic DNA fragmentation	"The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520]	PANTHER
NV2t022376001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022377001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022377001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t022377001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t022377002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022377002.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t022378001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022381001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022381001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022382001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022384001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022384001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022384002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022384002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022387001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022388001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022388001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022388001.1	molecular_function	GO:0005055	laminin receptor activity	"Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671]	OMA
NV2t022391001.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t022391002.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t022391003.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t022391004.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t022391006.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t022392001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t022392001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022392001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022392001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022394001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t022394001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022394001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022397001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022397001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t022397001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022397001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022397001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t022397001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022397001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022397001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022397002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022397002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022397002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022397002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022398001.1	molecular_function	GO:0017134	fibroblast growth factor binding	"Binding to a fibroblast growth factor." [PMID:9806903]	PANTHER
NV2t022399001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022399001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022399001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022399001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022400001.1	biological_process	GO:0019262	N-acetylneuraminate catabolic process	"The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]	PANTHER
NV2t022400001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t022400001.1	biological_process	GO:0046348	amino sugar catabolic process	"The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators]	OMA
NV2t022400001.1	biological_process	GO:0046395	carboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t022400001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t022400001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t022400001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t022400001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t022400002.1	biological_process	GO:0019262	N-acetylneuraminate catabolic process	"The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732]	PANTHER
NV2t022400002.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t022403001.1	biological_process	GO:0002183	cytoplasmic translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]	OMA
NV2t022403001.1	cellular_component	GO:0016281	eukaryotic translation initiation factor 4F complex	"The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:32883864, PMID:8449919]	OMA
NV2t022403001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t022403001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t022403001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t022403001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t022403001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022403001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022403002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t022403002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t022403002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022403003.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t022403003.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	PANTHER
NV2t022403003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022404001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t022404001.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t022404001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t022404002.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t022404002.1	biological_process	GO:0051123	RNA polymerase II preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." [GOC:txnOH, PMID:15020047, PMID:31300188]	PANTHER
NV2t022404002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t022405001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t022408001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022408001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t022408002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022409001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t022412001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	InterPro
NV2t022412001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t022412001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022412001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022412001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t022412001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t022412001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t022412001.1	molecular_function	GO:0004519	endonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]	OMA
NV2t022412001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t022413001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t022413001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022413001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t022413001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t022413001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t022413001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022413001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t022416001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022420001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t022420001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022420001.1	molecular_function	GO:0019783	ubiquitin-like protein peptidase activity	"An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins." [PMID:19489724]	OMA
NV2t022420001.1	molecular_function	GO:0019786	protein-phosphatidylethanolamide deconjugating activity	"Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328]	InterPro
NV2t022420002.1	molecular_function	GO:0019786	protein-phosphatidylethanolamide deconjugating activity	"Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328]	InterPro
NV2t022420003.1	molecular_function	GO:0019786	protein-phosphatidylethanolamide deconjugating activity	"Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328]	InterPro
NV2t022421001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	PANTHER
NV2t022421001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022421001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022423001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	PANTHER
NV2t022423001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022423001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022430001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022430001.1	molecular_function	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t022430001.1	molecular_function	GO:0046592	polyamine oxidase activity	"Catalysis of the oxidative degradation or interconversion of polyamines." [PMID:1567380]	PANTHER
NV2t022431001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022431001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t022431001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t022431002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022431002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t022432001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t022432001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t022432001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t022440001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t022442001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022442001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022444001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t022444001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t022444001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t022444001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022444001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022444001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022446001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022446001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t022446001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t022448001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022448001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022448001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t022448001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t022448001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t022449001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t022449001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t022449001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t022449001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t022449001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	PANTHER
NV2t022450001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	InterPro
NV2t022451001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022451001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022451001.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t022451001.1	molecular_function	GO:0140410	monoatomic cation:bicarbonate symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)." [PMID:27166256]	PANTHER
NV2t022454001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022454001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022455001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t022455002.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t022458001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t022458001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022458001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t022458002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t022458002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022458002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t022459001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022459001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t022459001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t022459001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t022459001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t022459001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t022459001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t022459002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022459002.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t022459002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t022459002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t022460001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t022460001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022460001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022460001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t022460001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t022460001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t022460001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t022460001.1	molecular_function	GO:0005254	chloride channel activity	"Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t022460001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t022460001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t022461001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022461001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022461001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022462001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t022462001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t022462001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t022462001.1	molecular_function	GO:0004721	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]	InterPro
NV2t022462001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t022462001.1	molecular_function	GO:0008962	phosphatidylglycerophosphatase activity	"Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [PMID:4292860]	PANTHER
NV2t022462002.1	molecular_function	GO:0008962	phosphatidylglycerophosphatase activity	"Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [PMID:4292860]	PANTHER
NV2t022465001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022465001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022465001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t022465001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t022465001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t022465001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t022465001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t022466001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t022466001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022466001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022466002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t022466002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t022466002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t022466002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022466002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t022466002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022466003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t022466003.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t022466003.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022467001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022467002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022468001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022469001.1	biological_process	GO:0051881	regulation of mitochondrial membrane potential	"Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]	InterPro
NV2t022471001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022471001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	InterPro
NV2t022474001.1	biological_process	GO:0000154	rRNA modification	"The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t022474001.1	biological_process	GO:0001522	pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine within an RNA molecule." [GOC:hjd, GOC:mah]	OMA
NV2t022474001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t022474001.1	biological_process	GO:0016556	mRNA modification	"The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t022474001.1	biological_process	GO:0031126	sno(s)RNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea." [GOC:krc, GOC:mah, PMID:17284456]	OMA
NV2t022474001.1	biological_process	GO:0040031	snRNA modification	"The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl]	OMA
NV2t022474001.1	biological_process	GO:1990481	mRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]	PANTHER
NV2t022474001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t022474001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t022474001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t022474001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t022474001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022474001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022474001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022474001.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t022474001.1	molecular_function	GO:0016866	intramolecular transferase activity	"Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t022474002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t022474002.1	biological_process	GO:1990481	mRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]	PANTHER
NV2t022474002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022474002.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t022474003.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t022474003.1	biological_process	GO:1990481	mRNA pseudouridine synthesis	"The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136]	PANTHER
NV2t022474003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022474003.1	molecular_function	GO:0009982	pseudouridine synthase activity	"Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah, RHEA:48348]	InterPro
NV2t022476001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t022476001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t022476001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t022476001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t022476001.1	biological_process	GO:0044260	obsolete cellular macromolecule metabolic process	"OBSOLETE. The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [GOC:mah]	OMA
NV2t022476001.1	biological_process	GO:0044804	nucleophagy	"A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549]	PANTHER
NV2t022476001.1	cellular_component	GO:0000153	cytoplasmic ubiquitin ligase complex	"A ubiquitin ligase complex found in the cytoplasm." [GOC:mah]	OMA
NV2t022476001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022476001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022476001.1	molecular_function	GO:0019787	ubiquitin-like protein transferase activity	"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]	InterPro
NV2t022476001.1	molecular_function	GO:0019787	ubiquitin-like protein transferase activity	"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]	OMA
NV2t022477001.1	biological_process	GO:0006302	double-strand break repair	"The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]	OMA
NV2t022477001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t022477001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t022477001.1	biological_process	GO:0051351	positive regulation of ligase activity	"Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]	PANTHER
NV2t022477001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022477001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t022477002.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t022477002.1	biological_process	GO:0051351	positive regulation of ligase activity	"Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]	PANTHER
NV2t022479001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t022479001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t022479001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t022479001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t022479001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t022479001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t022479001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t022479001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t022479001.1	biological_process	GO:0051650	establishment of vesicle localization	"The directed movement of a vesicle to a specific location." [GOC:ai]	OMA
NV2t022479001.1	cellular_component	GO:0030121	AP-1 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]	OMA
NV2t022479001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t022479001.1	molecular_function	GO:0035615	clathrin adaptor activity	"Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]	InterPro
NV2t022479001.1	molecular_function	GO:0035615	clathrin adaptor activity	"Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179]	OMA
NV2t022480001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022480001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022480001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022480001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022482001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022482001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022482001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022482002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022482002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022483001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t022483001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t022483001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t022483001.1	biological_process	GO:1901661	quinone metabolic process	"The chemical reactions and pathways involving quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie]	OMA
NV2t022483001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022483001.1	molecular_function	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	"Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]." [RHEA:24052]	OMA
NV2t022483001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022483001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t022483001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t022483001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t022486001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t022486001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t022486001.1	molecular_function	GO:0019148	D-cysteine desulfhydrase activity	"Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15]	PANTHER
NV2t022489001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t022493001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022493001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022493001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	InterPro
NV2t022493001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022493002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022493002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t022493002.1	biological_process	GO:0018107	peptidyl-threonine phosphorylation	"The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]	OMA
NV2t022493002.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022493002.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	InterPro
NV2t022493002.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t022493002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022493002.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t022493002.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t022493002.1	molecular_function	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	OMA
NV2t022493002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022493002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022493003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022493003.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022493003.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	InterPro
NV2t022493003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022494001.1	biological_process	GO:0006569	tryptophan catabolic process	"The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]	OMA
NV2t022494001.1	biological_process	GO:0009651	response to salt stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]	OMA
NV2t022494001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t022494001.1	biological_process	GO:0019674	NAD metabolic process	"The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]	OMA
NV2t022494001.1	biological_process	GO:0019805	quinolinate biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]	InterPro
NV2t022494001.1	biological_process	GO:0043650	dicarboxylic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]	OMA
NV2t022494001.1	biological_process	GO:0070189	kynurenine metabolic process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]	OMA
NV2t022494001.1	biological_process	GO:0070189	kynurenine metabolic process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]	PANTHER
NV2t022494001.1	biological_process	GO:0072525	pyridine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah]	OMA
NV2t022494001.1	biological_process	GO:1901216	obsolete positive regulation of neuron death	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t022494001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t022494001.1	molecular_function	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t022494001.1	molecular_function	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]	OMA
NV2t022494001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t022494001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t022494002.1	biological_process	GO:0070189	kynurenine metabolic process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]	PANTHER
NV2t022494002.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t022494003.1	biological_process	GO:0019805	quinolinate biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]	InterPro
NV2t022494003.1	biological_process	GO:0070189	kynurenine metabolic process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]	PANTHER
NV2t022494003.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t022494004.1	biological_process	GO:0019805	quinolinate biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]	InterPro
NV2t022494004.1	biological_process	GO:0070189	kynurenine metabolic process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]	PANTHER
NV2t022494004.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t022495001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022495001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022495002.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022495002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022495003.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022495003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022495004.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022495004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022495005.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022495005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022495006.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022495006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022495007.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022495007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022499001.1	biological_process	GO:0031144	proteasome localization	"Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah]	OMA
NV2t022499001.1	biological_process	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	"A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation." [PMID:20080635, PMID:21211726]	InterPro
NV2t022499001.1	biological_process	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	"A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation." [PMID:20080635, PMID:21211726]	OMA
NV2t022499001.1	biological_process	GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	"A protein quality control pathway that results in the breakdown of misfolded, damaged or unassembled proteins via a mechanism in which the proteins are ubiquitinated, and then targeted to nuclear proteasomes for degradation." [PMID:20080635, PMID:21211726]	PANTHER
NV2t022499001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022500001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t022500002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t022500003.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t022502001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	InterPro
NV2t022502001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t022502001.1	biological_process	GO:0006637	acyl-CoA metabolic process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]	OMA
NV2t022502001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022502001.1	cellular_component	GO:0042709	succinate-CoA ligase complex	"A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [GOC:jl, PMID:10671455]	PANTHER
NV2t022502001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t022502001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t022502001.1	molecular_function	GO:0004774	succinate-CoA ligase activity	"Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [GOC:ai]	OMA
NV2t022502001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022502001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022502001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t022505001.1	molecular_function	GO:0019135	deoxyhypusine monooxygenase activity	"Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29]	InterPro
NV2t022505001.1	molecular_function	GO:0019135	deoxyhypusine monooxygenase activity	"Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29]	PANTHER
NV2t022506001.1	biological_process	GO:0007130	synaptonemal complex assembly	"The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]	OMA
NV2t022506001.1	cellular_component	GO:0000795	synaptonemal complex	"A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh]	OMA
NV2t022507001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t022508001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t022508001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t022509001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022509001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t022509001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t022509002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022509002.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t022509002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t022509003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022509003.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t022509003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t022509004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022509004.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t022509004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t022510001.1	biological_process	GO:0009914	hormone transport	"The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]	OMA
NV2t022510001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022510001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022510001.1	molecular_function	GO:0015291	secondary active transmembrane transporter activity	"Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]	OMA
NV2t022510001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022512001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t022512001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	InterPro
NV2t022512002.1	biological_process	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	"The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]	InterPro
NV2t022513001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022513001.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t022513001.1	cellular_component	GO:0005753	mitochondrial proton-transporting ATP synthase complex	"A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]	OMA
NV2t022513001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t022513001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t022513001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	PANTHER
NV2t022514001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t022514001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022514001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t022514001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t022514001.1	molecular_function	GO:1990259	histone H2AQ104 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to Q105 in yeast." [PMID:24352239]	PANTHER
NV2t022515001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022516001.1	biological_process	GO:0006413	translational initiation	"The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]	InterPro
NV2t022516001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022516001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	PANTHER
NV2t022518001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t022518001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022519001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t022519001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022519001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t022519001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t022521001.1	biological_process	GO:0048384	retinoic acid receptor signaling pathway	"The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands." [GOC:dgh]	InterPro
NV2t022521001.1	molecular_function	GO:0004879	nuclear receptor activity	"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]	OMA
NV2t022521001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022521001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022521001.1	molecular_function	GO:0034056	estrogen response element binding	"Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005]	PANTHER
NV2t022521001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t022521001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t022523001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022524001.1	biological_process	GO:0000380	alternative mRNA splicing, via spliceosome	"The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]	OMA
NV2t022524001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	InterPro
NV2t022524001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	OMA
NV2t022524001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t022524001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022524001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022524001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022525001.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	PANTHER
NV2t022525001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t022525001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022525002.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	PANTHER
NV2t022525002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t022525002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022525003.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	PANTHER
NV2t022525003.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t022525003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022525004.1	biological_process	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]	OMA
NV2t022525004.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t022525004.1	biological_process	GO:0007276	gamete generation	"The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]	OMA
NV2t022525004.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t022525004.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t022525004.1	biological_process	GO:0033962	P-body assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]	OMA
NV2t022525004.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	OMA
NV2t022525004.1	biological_process	GO:0034063	stress granule assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]	PANTHER
NV2t022525004.1	biological_process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	"An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs." [PMID:14744438, PMID:15196554]	OMA
NV2t022525004.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t022525004.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t022525004.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022525004.1	cellular_component	GO:0010494	cytoplasmic stress granule	"A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989]	OMA
NV2t022525004.1	cellular_component	GO:0016442	RISC complex	"A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]	OMA
NV2t022525004.1	cellular_component	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]	OMA
NV2t022525004.1	cellular_component	GO:0120025	plasma membrane bounded cell projection	"A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t022525004.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t022525004.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t022525004.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t022525004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022525004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022525004.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t022526001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t022526001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022526001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022526001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022526001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022526001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022529001.1	biological_process	GO:0045017	glycerolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	InterPro
NV2t022529001.1	biological_process	GO:0045017	glycerolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t022529001.1	molecular_function	GO:0004144	diacylglycerol O-acyltransferase activity	"Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]	OMA
NV2t022530001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t022530001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022530001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t022530001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t022531001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	InterPro
NV2t022531001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t022531002.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	InterPro
NV2t022531002.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t022531003.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t022532001.1	biological_process	GO:0030576	Cajal body organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238]	OMA
NV2t022532001.1	biological_process	GO:0030576	Cajal body organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238]	PANTHER
NV2t022532001.1	cellular_component	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	OMA
NV2t022532001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022532001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022534001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t022535001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	OMA
NV2t022535001.1	biological_process	GO:0033490	cholesterol biosynthetic process via lathosterol	"The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341]	PANTHER
NV2t022535001.1	biological_process	GO:1902653	secondary alcohol biosynthetic process	"The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t022535001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t022535001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022535001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022535001.1	molecular_function	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]	OMA
NV2t022536001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t022536001.1	biological_process	GO:0033490	cholesterol biosynthetic process via lathosterol	"The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341]	PANTHER
NV2t022536001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022536001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022536001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t022537001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022537001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022537001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022537001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	PANTHER
NV2t022539001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t022539001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t022539001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	OMA
NV2t022539001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t022539001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022539001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t022539001.1	molecular_function	GO:0033204	ribonuclease P RNA binding	"Binding to RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963]	PANTHER
NV2t022539001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t022541001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t022541001.1	biological_process	GO:0016973	poly(A)+ mRNA export from nucleus	"The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]	OMA
NV2t022541001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t022541001.1	biological_process	GO:0043488	regulation of mRNA stability	"Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]	OMA
NV2t022541001.1	biological_process	GO:0045595	regulation of cell differentiation	"Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]	OMA
NV2t022541001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022541001.1	biological_process	GO:0048534	hematopoietic or lymphoid organ development	"The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149]	OMA
NV2t022541001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t022541001.1	biological_process	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	"Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw]	OMA
NV2t022541001.1	biological_process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf]	OMA
NV2t022541001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022541001.1	cellular_component	GO:0044615	nuclear pore nuclear basket	"A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]	OMA
NV2t022541001.1	cellular_component	GO:0070390	transcription export complex 2	"A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829]	OMA
NV2t022541001.1	cellular_component	GO:0070390	transcription export complex 2	"A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829]	PANTHER
NV2t022541001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t022541001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022541001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022542001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t022542001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t022542001.1	biological_process	GO:0007017	microtubule-based process	"Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]	InterPro
NV2t022542001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022542001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t022542001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t022542001.1	molecular_function	GO:0005200	structural constituent of cytoskeleton	"The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]	OMA
NV2t022542001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022542001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t022544001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	InterPro
NV2t022544001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t022544001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t022544001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t022545001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022545001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t022547001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t022547001.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t022547002.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t022547002.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t022547003.1	biological_process	GO:0006826	iron ion transport	"The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t022547003.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t022547003.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022547003.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t022547003.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t022547003.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t022547004.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t022547004.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t022547005.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t022547005.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t022547006.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	InterPro
NV2t022547006.1	molecular_function	GO:0008199	ferric iron binding	"Binding to a ferric iron ion, Fe(III)." [GOC:ai]	PANTHER
NV2t022548001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t022548001.1	biological_process	GO:0006625	protein targeting to peroxisome	"The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]	OMA
NV2t022548001.1	biological_process	GO:0015919	peroxisomal membrane transport	"The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai]	OMA
NV2t022548001.1	biological_process	GO:0045046	protein import into peroxisome membrane	"The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502]	PANTHER
NV2t022548001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	InterPro
NV2t022548001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t022548001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022548001.1	molecular_function	GO:0005048	signal sequence binding	"Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]	OMA
NV2t022549001.1	biological_process	GO:0006729	tetrahydrobiopterin biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]	OMA
NV2t022549001.1	molecular_function	GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	"Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O." [EC:4.2.1.96, RHEA:11920]	InterPro
NV2t022549001.1	molecular_function	GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	"Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O." [EC:4.2.1.96, RHEA:11920]	PANTHER
NV2t022549001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t022551001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022551001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022558001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t022558002.1	biological_process	GO:0007288	sperm axoneme assembly	"The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t022558002.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t022558002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022558002.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t022558002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022560001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t022560001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t022560001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t022560001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t022560001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t022560001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t022560001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022560001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022561001.1	biological_process	GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	"The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb]	InterPro
NV2t022561001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t022561001.1	molecular_function	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	"Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022563001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	InterPro
NV2t022563001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	OMA
NV2t022563001.1	cellular_component	GO:0034518	RNA cap binding complex	"A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation." [GOC:mah]	OMA
NV2t022563001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t022563001.1	molecular_function	GO:0000339	RNA cap binding	"Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc]	OMA
NV2t022563001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022563001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022564001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022564001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022564001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022564001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022564001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t022566001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022566001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t022566002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022566002.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t022568001.1	biological_process	GO:0006749	glutathione metabolic process	"The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732]	PANTHER
NV2t022568001.1	biological_process	GO:1901170	naphthalene catabolic process	"The chemical reactions and pathways resulting in the breakdown of naphthalene." [GOC:TermGenie, GOC:yaf, PMID:11133965]	InterPro
NV2t022568001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022568001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t022569001.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t022569001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022569002.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t022569002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022569003.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t022569005.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t022569005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022569006.1	biological_process	GO:0070286	axonemal dynein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621]	PANTHER
NV2t022569006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022571001.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t022571001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022571002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022571002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t022571002.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t022571002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022571003.1	biological_process	GO:0045329	carnitine biosynthetic process	"The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	PANTHER
NV2t022571003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022571004.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t022571004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022572001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t022572001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022572002.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t022572002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022573001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t022573001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022573001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t022573001.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022573001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t022574001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022574001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022574001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t022574001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022576001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t022576001.1	biological_process	GO:0006360	transcription by RNA polymerase I	"The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH]	OMA
NV2t022576001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t022576001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	OMA
NV2t022576001.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	OMA
NV2t022576001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t022576001.1	cellular_component	GO:0032993	protein-DNA complex	"A macromolecular complex containing both protein and DNA molecules." [GOC:mah]	OMA
NV2t022576001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t022576001.1	molecular_function	GO:0003899	DNA-directed 5'-3' RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf]	OMA
NV2t022576001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022577001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t022577002.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t022577002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022577003.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	InterPro
NV2t022577003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022578001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022578001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022578001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t022579001.1	biological_process	GO:0006221	pyrimidine nucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022579001.1	biological_process	GO:0006233	dTDP biosynthetic process	"The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732]	InterPro
NV2t022579001.1	biological_process	GO:0006235	dTTP biosynthetic process	"The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732]	PANTHER
NV2t022579001.1	biological_process	GO:0009116	nucleoside metabolic process	"The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]	OMA
NV2t022579001.1	biological_process	GO:0009132	nucleoside diphosphate metabolic process	"The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022579001.1	biological_process	GO:0009148	pyrimidine nucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022579001.1	biological_process	GO:0009211	pyrimidine deoxyribonucleoside triphosphate metabolic process	"The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022579001.1	biological_process	GO:0009219	pyrimidine deoxyribonucleotide metabolic process	"The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t022579001.1	biological_process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah]	OMA
NV2t022579001.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t022579001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022579001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022579001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t022579001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022579001.1	molecular_function	GO:0009041	UMP/dUMP kinase activity	"Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators]	OMA
NV2t022580001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022582001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022582001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022582001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t022582001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022584001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t022584001.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t022584001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022584001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022584001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t022585001.1	biological_process	GO:0006509	membrane protein ectodomain proteolysis	"The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]	OMA
NV2t022585001.1	biological_process	GO:0007220	Notch receptor processing	"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]	OMA
NV2t022585001.1	biological_process	GO:0010950	positive regulation of endopeptidase activity	"Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t022585001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	InterPro
NV2t022585001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	OMA
NV2t022585001.1	biological_process	GO:0031293	membrane protein intracellular domain proteolysis	"The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018]	OMA
NV2t022585001.1	biological_process	GO:0034205	amyloid-beta formation	"The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP)." [GOC:mah]	OMA
NV2t022585001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t022585001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t022585001.1	cellular_component	GO:0070765	gamma-secretase complex	"A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein." [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437]	OMA
NV2t022585001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t022585001.1	molecular_function	GO:0030674	protein-macromolecule adaptor activity	"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw]	OMA
NV2t022585001.1	molecular_function	GO:0070851	growth factor receptor binding	"Binding to a growth factor receptor." [GOC:mah, GOC:vw]	OMA
NV2t022586001.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t022586001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t022586001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t022586001.1	biological_process	GO:0042148	DNA strand invasion	"The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855]	PANTHER
NV2t022586001.1	cellular_component	GO:0005657	replication fork	"The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]	OMA
NV2t022586001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t022586001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t022586001.1	molecular_function	GO:0000400	four-way junction DNA binding	"Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]	OMA
NV2t022586001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022586001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t022586001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t022586001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t022588001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022588001.1	cellular_component	GO:0045281	succinate dehydrogenase complex	"A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701]	InterPro
NV2t022588001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t022589001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t022589001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022589002.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t022589002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022589003.1	biological_process	GO:0000722	telomere maintenance via recombination	"Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777]	OMA
NV2t022589003.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t022589003.1	biological_process	GO:0051984	positive regulation of chromosome segregation	"Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]	OMA
NV2t022589003.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t022589003.1	cellular_component	GO:0000793	condensed chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]	OMA
NV2t022589003.1	cellular_component	GO:0000803	sex chromosome	"A chromosome involved in sex determination." [GOC:elh]	OMA
NV2t022589003.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t022589003.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t022589003.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t022589003.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t022589003.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t022589003.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t022589003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022589003.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t022589003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t022589003.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t022589003.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t022589004.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t022590001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	OMA
NV2t022590001.1	biological_process	GO:0035082	axoneme assembly	"The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194]	PANTHER
NV2t022591001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022591002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022591002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t022592001.1	biological_process	GO:0019432	triglyceride biosynthetic process	"The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732]	PANTHER
NV2t022592001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t022592001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t022593001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t022593001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022593001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022593001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t022593002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t022593002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022593002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022593002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t022593003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t022593003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022593003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022593003.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t022594001.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	InterPro
NV2t022594001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022594001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022594001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022594002.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t022594002.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	InterPro
NV2t022594002.1	cellular_component	GO:0089701	U2AF complex	"A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]	OMA
NV2t022594002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t022594002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022594002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022594002.1	molecular_function	GO:0036002	pre-mRNA binding	"Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]	OMA
NV2t022594002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022594002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t022595001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t022595001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022595001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022595001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022595001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022595001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t022595001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t022597001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022597001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022597001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022597001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022598001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022598001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022598001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022598001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022600001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022602001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022602001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022602001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022603001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t022603001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t022603001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t022603001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t022603001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t022603001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t022603001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t022603001.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t022603001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t022603002.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t022603002.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t022603003.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t022603003.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t022603004.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t022603004.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t022603005.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t022603005.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t022604001.1	biological_process	GO:0001736	establishment of planar polarity	"Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]	OMA
NV2t022604001.1	biological_process	GO:0001838	embryonic epithelial tube formation	"The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]	OMA
NV2t022604001.1	biological_process	GO:0003143	embryonic heart tube morphogenesis	"The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]	OMA
NV2t022604001.1	biological_process	GO:0003401	axis elongation	"The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t022604001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t022604001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t022604001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t022604001.1	biological_process	GO:0008544	epidermis development	"The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003]	OMA
NV2t022604001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t022604001.1	biological_process	GO:0009952	anterior/posterior pattern specification	"The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]	OMA
NV2t022604001.1	biological_process	GO:0009967	positive regulation of signal transduction	"Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t022604001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t022604001.1	biological_process	GO:0030111	regulation of Wnt signaling pathway	"Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t022604001.1	biological_process	GO:0035567	non-canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin." [PMID:37804416]	OMA
NV2t022604001.1	biological_process	GO:0045176	apical protein localization	"Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]	OMA
NV2t022604001.1	biological_process	GO:0048546	digestive tract morphogenesis	"The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131]	OMA
NV2t022604001.1	biological_process	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t022604001.1	biological_process	GO:0060027	convergent extension involved in gastrulation	"The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082]	OMA
NV2t022604001.1	biological_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	"A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton." [PMID:11532397, PMID:25349257, PMID:28293032, PMID:37804416]	PANTHER
NV2t022604001.1	biological_process	GO:0061061	muscle structure development	"The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph]	OMA
NV2t022604001.1	biological_process	GO:0072001	renal system development	"The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System]	OMA
NV2t022604001.1	biological_process	GO:0090175	regulation of establishment of planar polarity	"Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t022604001.1	biological_process	GO:0090596	sensory organ morphogenesis	"Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893]	OMA
NV2t022604001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	OMA
NV2t022604001.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t022604001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022604001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t022604001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t022604001.1	cellular_component	GO:0016328	lateral plasma membrane	"The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]	OMA
NV2t022604001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022609001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t022609002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t022610001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t022612001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t022612001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022614001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022615001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t022615001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022615001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t022615001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t022616001.1	biological_process	GO:0000820	regulation of glutamine family amino acid metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators]	OMA
NV2t022616001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022616001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022616001.1	molecular_function	GO:0015174	basic amino acid transmembrane transporter activity	"Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022616001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022616001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t022618001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t022618001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t022618001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022618001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t022618001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t022618001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t022619001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t022619001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t022619001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	InterPro
NV2t022619001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	OMA
NV2t022622001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t022622001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t022622001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022622001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022622001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t022622001.1	molecular_function	GO:0005539	glycosaminoglycan binding	"Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t022624001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t022624001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022626001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t022626001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t022626001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022626001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022626001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t022626001.1	molecular_function	GO:0005539	glycosaminoglycan binding	"Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t022627001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022627001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022627001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t022627001.1	molecular_function	GO:0005539	glycosaminoglycan binding	"Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t022629001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t022629001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	OMA
NV2t022629001.1	biological_process	GO:0072657	protein localization to membrane	"A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah]	PANTHER
NV2t022629001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022629001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t022629001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022629001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022629001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t022632001.1	biological_process	GO:0007129	homologous chromosome pairing at meiosis	"The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152]	OMA
NV2t022632001.1	biological_process	GO:0034085	establishment of sister chromatid cohesion	"The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase." [GOC:jh, GOC:mah, PMID:14623866]	OMA
NV2t022632001.1	biological_process	GO:0051177	meiotic sister chromatid cohesion	"The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai]	OMA
NV2t022632001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t022632001.1	cellular_component	GO:0000795	synaptonemal complex	"A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh]	OMA
NV2t022632001.1	cellular_component	GO:0008278	cohesin complex	"A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]	OMA
NV2t022632001.1	cellular_component	GO:0008278	cohesin complex	"A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095]	PANTHER
NV2t022632001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t022633001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t022633001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022633001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022633001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022635001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t022635001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022635001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022636001.1	cellular_component	GO:0031213	RSF complex	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179]	InterPro
NV2t022638001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t022638001.1	molecular_function	GO:0019148	D-cysteine desulfhydrase activity	"Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15]	PANTHER
NV2t022641001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022642001.1	biological_process	GO:0006188	IMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732]	OMA
NV2t022642001.1	biological_process	GO:0032264	IMP salvage	"Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]	InterPro
NV2t022642001.1	biological_process	GO:0046033	AMP metabolic process	"The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators]	PANTHER
NV2t022642001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022642001.1	molecular_function	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	OMA
NV2t022642001.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	InterPro
NV2t022642001.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	OMA
NV2t022642002.1	biological_process	GO:0032264	IMP salvage	"Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]	InterPro
NV2t022642002.1	biological_process	GO:0046033	AMP metabolic process	"The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators]	PANTHER
NV2t022642002.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	InterPro
NV2t022642003.1	biological_process	GO:0032264	IMP salvage	"Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]	InterPro
NV2t022642003.1	biological_process	GO:0046033	AMP metabolic process	"The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators]	PANTHER
NV2t022643001.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	PANTHER
NV2t022643002.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	PANTHER
NV2t022643003.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	PANTHER
NV2t022643004.1	molecular_function	GO:1990380	K48-linked deubiquitinase activity	"Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin." [GOC:bf, GOC:PARL, PMID:22970133]	PANTHER
NV2t022643005.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t022643005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022646001.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646002.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646003.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646004.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646005.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646005.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646006.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646006.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646007.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646007.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646008.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646008.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646009.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646009.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646010.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646010.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646011.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646011.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646012.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646012.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022646013.1	biological_process	GO:0043484	regulation of RNA splicing	"Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]	PANTHER
NV2t022646013.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022647001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t022648001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	InterPro
NV2t022648001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t022648001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t022651001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t022651001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022651001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t022651001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t022651001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022652001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022652001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t022653001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022653001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t022653001.1	molecular_function	GO:0008240	tripeptidyl-peptidase activity	"Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]	PANTHER
NV2t022654001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022654001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t022654001.1	molecular_function	GO:0008240	tripeptidyl-peptidase activity	"Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]	PANTHER
NV2t022655001.1	biological_process	GO:0034620	cellular response to unfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]	OMA
NV2t022655001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t022655001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t022655001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022655001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022655001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	PANTHER
NV2t022656001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022656001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022656001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022656001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022656001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t022656001.1	molecular_function	GO:0008240	tripeptidyl-peptidase activity	"Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]	OMA
NV2t022656001.1	molecular_function	GO:0008240	tripeptidyl-peptidase activity	"Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]	PANTHER
NV2t022659001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022659001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t022659001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t022659001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022659001.1	cellular_component	GO:0005667	transcription regulator complex	"A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]	OMA
NV2t022659001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t022659001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022660001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022661001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t022661001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022661001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022663001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022663001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022663001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022663001.1	molecular_function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022663001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022664001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t022664001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t022664001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t022664001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t022664001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t022664002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t022664002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t022664003.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t022664003.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t022664004.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t022664004.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t022664005.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t022664005.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t022664006.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t022664006.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t022665001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022665001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022668001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t022668001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t022668001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	InterPro
NV2t022668001.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	OMA
NV2t022668002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t022668002.1	molecular_function	GO:0004565	beta-galactosidase activity	"Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]	InterPro
NV2t022669001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t022669001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t022669001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	OMA
NV2t022669001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	PANTHER
NV2t022669001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022669001.1	cellular_component	GO:0001669	acrosomal vesicle	"A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]	OMA
NV2t022669001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t022669001.1	molecular_function	GO:0005245	voltage-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]	OMA
NV2t022669002.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	PANTHER
NV2t022669002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022669003.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	PANTHER
NV2t022669003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t022670001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t022670001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022670001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	InterPro
NV2t022670001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t022672001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t022672001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022674001.1	biological_process	GO:0006507	GPI anchor release	"The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane." [GOC:mah, PMID:18811934]	OMA
NV2t022674001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t022674001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t022674001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t022674001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t022674001.1	molecular_function	GO:0004630	phospholipase D activity	"Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4]	OMA
NV2t022675001.1	biological_process	GO:0015813	L-glutamate transmembrane transport	"The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	PANTHER
NV2t022675001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022675001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022675001.1	molecular_function	GO:0005313	L-glutamate transmembrane transporter activity	"Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022675001.1	molecular_function	GO:0015175	neutral L-amino acid transmembrane transporter activity	"Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022675001.1	molecular_function	GO:0015501	glutamate:sodium symporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1]	OMA
NV2t022675002.1	biological_process	GO:0015813	L-glutamate transmembrane transport	"The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	PANTHER
NV2t022675002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022676001.1	biological_process	GO:0006650	glycerophospholipid metabolic process	"The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732]	OMA
NV2t022676001.1	biological_process	GO:0010677	obsolete negative regulation of cellular carbohydrate metabolic process	"OBSOLETE. Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]	OMA
NV2t022676001.1	biological_process	GO:0010906	regulation of glucose metabolic process	"Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]	OMA
NV2t022676001.1	biological_process	GO:0019400	alditol metabolic process	"The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732]	OMA
NV2t022676001.1	biological_process	GO:0031327	negative regulation of cellular biosynthetic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t022676001.1	biological_process	GO:0034637	obsolete cellular carbohydrate biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah]	OMA
NV2t022676001.1	biological_process	GO:0043255	regulation of carbohydrate biosynthetic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]	OMA
NV2t022676001.1	biological_process	GO:0046173	polyol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators]	OMA
NV2t022676001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022676001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t022676001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t022676001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t022676001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	PANTHER
NV2t022678001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t022678002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t022678002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t022678002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t022678002.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	InterPro
NV2t022678002.1	molecular_function	GO:0016885	ligase activity, forming carbon-carbon bonds	"Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-, GOC:jl, GOC:mah]	OMA
NV2t022679001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t022679001.1	cellular_component	GO:0072487	MSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]	InterPro
NV2t022679001.1	cellular_component	GO:0072487	MSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852]	OMA
NV2t022679001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t022679001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t022680001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t022680001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t022680001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t022680001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022680001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t022682001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t022683001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t022683001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t022683001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t022683001.1	biological_process	GO:0071230	cellular response to amino acid stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah]	OMA
NV2t022683001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	OMA
NV2t022683001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022683001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t022683001.1	cellular_component	GO:1905360	GTPase complex	"A protein complex which is capable of GTPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006]	OMA
NV2t022683001.1	cellular_component	GO:1990131	Gtr1-Gtr2 GTPase complex	"A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins." [GOC:rb, PMID:10388807, PMID:16143306]	PANTHER
NV2t022683001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t022683001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022683001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022683001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t022685001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t022685001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t022685001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	PANTHER
NV2t022685001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t022685001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022685001.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	OMA
NV2t022685001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022685001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t022686001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022686001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t022687001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t022687001.1	biological_process	GO:0009226	nucleotide-sugar biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]	OMA
NV2t022687001.1	biological_process	GO:0009298	GDP-mannose biosynthetic process	"The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	InterPro
NV2t022687001.1	biological_process	GO:0009298	GDP-mannose biosynthetic process	"The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]	PANTHER
NV2t022687001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022687001.1	molecular_function	GO:0004476	mannose-6-phosphate isomerase activity	"Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8]	InterPro
NV2t022687001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022687001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022687001.1	molecular_function	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]	OMA
NV2t022688001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022688001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022688001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t022690001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t022690001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022691001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	InterPro
NV2t022691001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t022691001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022691001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022692001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t022692001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t022692001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t022692001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	InterPro
NV2t022692001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t022693001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022693001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022693001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t022693002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022693002.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t022693003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022693003.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t022694001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t022694001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t022694001.1	biological_process	GO:0006268	DNA unwinding involved in DNA replication	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]	OMA
NV2t022694001.1	biological_process	GO:0006270	DNA replication initiation	"The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding." [PMID:28209641]	OMA
NV2t022694001.1	biological_process	GO:0019219	regulation of nucleobase-containing compound metabolic process	"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	OMA
NV2t022694001.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t022694001.1	biological_process	GO:0042325	regulation of phosphorylation	"Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]	OMA
NV2t022694001.1	biological_process	GO:0060255	regulation of macromolecule metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t022694001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t022694001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022694001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	InterPro
NV2t022694001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	OMA
NV2t022694001.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	PANTHER
NV2t022694001.1	cellular_component	GO:0071162	CMG complex	"A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417]	OMA
NV2t022694001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t022694001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022694001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022694001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022694001.1	molecular_function	GO:0017116	single-stranded DNA helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl]	OMA
NV2t022694002.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t022694002.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t022694002.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	InterPro
NV2t022694002.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	PANTHER
NV2t022694002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022694003.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t022694003.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t022694003.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	InterPro
NV2t022694003.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	PANTHER
NV2t022694003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022694004.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t022694004.1	biological_process	GO:0032508	DNA duplex unwinding	"The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]	InterPro
NV2t022694004.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	InterPro
NV2t022694004.1	cellular_component	GO:0042555	MCM complex	"A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]	PANTHER
NV2t022694004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022695001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t022695001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	PANTHER
NV2t022695002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t022695002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	PANTHER
NV2t022695003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t022695003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	PANTHER
NV2t022696001.1	biological_process	GO:0071679	commissural neuron axon guidance	"The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]	PANTHER
NV2t022696001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022698001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022698001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t022698001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t022698001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022698001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022698001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022698001.1	molecular_function	GO:0008241	peptidyl-dipeptidase activity	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]	OMA
NV2t022701001.1	molecular_function	GO:0017128	phospholipid scramblase activity	"Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]	InterPro
NV2t022703001.1	biological_process	GO:0032386	regulation of intracellular transport	"Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]	OMA
NV2t022703001.1	biological_process	GO:0035721	intraciliary retrograde transport	"The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia]	OMA
NV2t022703001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t022703001.1	biological_process	GO:0060632	regulation of microtubule-based movement	"Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]	OMA
NV2t022703001.1	biological_process	GO:1902017	regulation of cilium assembly	"Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]	OMA
NV2t022703001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t022703001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t022703001.1	cellular_component	GO:0005868	cytoplasmic dynein complex	"Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311]	OMA
NV2t022703001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t022703001.1	cellular_component	GO:0031021	interphase microtubule organizing center	"A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790]	OMA
NV2t022703001.1	cellular_component	GO:0097546	ciliary base	"Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444]	OMA
NV2t022703001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022703001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t022707001.1	biological_process	GO:0006955	immune response	"Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add]	OMA
NV2t022707001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022707001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022707001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022707001.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t022721001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t022721001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t022721001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022721001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022721001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t022721001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t022723001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t022723001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t022723001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t022723001.1	cellular_component	GO:0031307	obsolete integral component of mitochondrial outer membrane	"OBSOLETE. The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t022724001.1	biological_process	GO:0042073	intraciliary transport	"The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2]	OMA
NV2t022724001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	InterPro
NV2t022724001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t022724001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t022724001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t022724001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t022724001.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t022725001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t022725001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t022725001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022725001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022725001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t022726002.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t022726003.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t022727001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022727001.1	molecular_function	GO:0051787	misfolded protein binding	"Binding to a misfolded protein." [GOC:ai]	PANTHER
NV2t022728001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022728001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022728001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022731001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022731001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022733001.1	molecular_function	GO:0008484	sulfuric ester hydrolase activity	"Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]	OMA
NV2t022735001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022735001.1	molecular_function	GO:0036122	BMP binding	"Binding to a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951]	PANTHER
NV2t022736001.1	biological_process	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	InterPro
NV2t022736001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t022738001.1	biological_process	GO:0015813	L-glutamate transmembrane transport	"The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore." [PMID:21307582]	PANTHER
NV2t022738001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022738001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t022740001.1	biological_process	GO:0030890	positive regulation of B cell proliferation	"Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah]	PANTHER
NV2t022740001.1	molecular_function	GO:0003953	NAD+ nucleosidase activity	"Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]	InterPro
NV2t022740002.1	biological_process	GO:0030890	positive regulation of B cell proliferation	"Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah]	PANTHER
NV2t022740002.1	molecular_function	GO:0003953	NAD+ nucleosidase activity	"Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]	InterPro
NV2t022740002.1	molecular_function	GO:0003953	NAD+ nucleosidase activity	"Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]	OMA
NV2t022745001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022745001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022745001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t022745001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022745001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022747001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	OMA
NV2t022747001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t022747001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t022747001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022749001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t022749001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t022749001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t022749001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t022749001.1	biological_process	GO:0070593	dendrite self-avoidance	"The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]	OMA
NV2t022749001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022749001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022749001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t022749001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022749001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t022750001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022750001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022750002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022750002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022751001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022752003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t022752003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t022756001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022756001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022756001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022756001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022756001.1	molecular_function	GO:0008241	peptidyl-dipeptidase activity	"Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]	OMA
NV2t022758001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022758001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022758001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t022758001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022760001.1	biological_process	GO:1903724	positive regulation of centriole elongation	"Any process that activates or increases the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]	PANTHER
NV2t022763001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t022767001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	OMA
NV2t022767001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022767001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t022767001.1	molecular_function	GO:0016783	sulfurtransferase activity	"Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544]	OMA
NV2t022771001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t022772001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t022772001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t022772001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t022772001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t022772001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t022773001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t022773001.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t022773001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t022773001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022773001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022773001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022773001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022773001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t022773001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022774001.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	PANTHER
NV2t022779001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t022779001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022779001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t022780001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022781001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t022783001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	PANTHER
NV2t022783003.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	PANTHER
NV2t022783004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t022783005.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t022784001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t022784001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t022784001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t022784001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t022784001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022784001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t022784001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022785001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t022785001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t022785001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t022785001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022785001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t022785001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022787001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t022787001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	InterPro
NV2t022787001.1	cellular_component	GO:0030286	dynein complex	"Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]	OMA
NV2t022787001.1	molecular_function	GO:0003777	microtubule motor activity	"A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864]	OMA
NV2t022787001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022787001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t022787001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	OMA
NV2t022789001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022789001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t022789001.1	molecular_function	GO:0051959	dynein light intermediate chain binding	"Binding to a light intermediate chain of the dynein complex." [GOC:bf]	InterPro
NV2t022791001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t022791001.1	biological_process	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	"The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309]	InterPro
NV2t022791001.1	biological_process	GO:0044255	cellular lipid metabolic process	"The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]	OMA
NV2t022791001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t022791001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022791001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	InterPro
NV2t022791001.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t022793001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022793001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t022793001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022794001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t022794001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	OMA
NV2t022794001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	InterPro
NV2t022794001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t022794001.1	molecular_function	GO:0050152	omega-amidase activity	"Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN]	PANTHER
NV2t022797001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022797001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t022797001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022798001.1	biological_process	GO:0006541	glutamine metabolic process	"The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]	OMA
NV2t022798001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t022798001.1	biological_process	GO:0009066	aspartate family amino acid metabolic process	"The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t022798001.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t022798001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	InterPro
NV2t022798001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t022798001.1	molecular_function	GO:0050152	omega-amidase activity	"Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN]	PANTHER
NV2t022800001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t022801001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t022802001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t022803001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022803001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t022803002.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	InterPro
NV2t022803002.1	molecular_function	GO:0001784	phosphotyrosine residue binding	"Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584]	InterPro
NV2t022803002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t022804001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t022804001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022804001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t022804002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022804002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t022806001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	InterPro
NV2t022806002.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	InterPro
NV2t022806003.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	InterPro
NV2t022806004.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	InterPro
NV2t022806005.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	InterPro
NV2t022806006.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	InterPro
NV2t022806007.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	InterPro
NV2t022807001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	PANTHER
NV2t022807001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022807001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022808001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	PANTHER
NV2t022808001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t022808001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022808002.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	PANTHER
NV2t022808002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022808002.1	molecular_function	GO:0042800	histone H3K4 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein." [PMID:12086618]	OMA
NV2t022813001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022813001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022813001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022817001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t022817001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t022817001.1	molecular_function	GO:0005179	hormone activity	"The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]	OMA
NV2t022823002.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t022823002.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t022823002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t022823002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022823002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t022823002.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t022823003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t022823003.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t022825001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t022825001.1	biological_process	GO:0007007	inner mitochondrial membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t022825001.1	biological_process	GO:0030308	negative regulation of cell growth	"Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t022825001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t022825001.1	biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t022825001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t022825001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022825001.1	biological_process	GO:0051205	protein insertion into membrane	"The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]	OMA
NV2t022825001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t022825001.1	biological_process	GO:0071396	cellular response to lipid	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]	OMA
NV2t022825001.1	biological_process	GO:0072593	reactive oxygen species metabolic process	"The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah]	OMA
NV2t022825001.1	biological_process	GO:0090151	establishment of protein localization to mitochondrial membrane	"The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t022825001.1	biological_process	GO:0097190	apoptotic signaling pathway	"The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]	OMA
NV2t022825001.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t022825001.1	biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t022825001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t022825001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t022825001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t022825001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t022826001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t022826001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t022826001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022826001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t022830001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022830001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022830001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t022833001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022833001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022834001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t022836001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t022837001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022837001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022837002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022837002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022837003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022837003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022838001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022838001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022838001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022840001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t022843001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t022843001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t022843001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t022843001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t022845001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t022845001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022845001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022845001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022846001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t022846001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t022846002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t022846003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t022846003.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t022846004.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t022846004.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t022846004.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t022846004.1	cellular_component	GO:0030904	retromer complex	"A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157]	OMA
NV2t022846004.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t022846004.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t022846004.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t022846005.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t022846005.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t022846006.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t022846006.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t022851001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t022851001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022851001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022851001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t022851001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t022851002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022851003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022851004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t022851005.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t022853001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t022853001.1	biological_process	GO:0051225	spindle assembly	"The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]	OMA
NV2t022853001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022853001.1	cellular_component	GO:0005875	microtubule associated complex	"Any multimeric complex connected to a microtubule." [GOC:jl]	OMA
NV2t022853001.1	cellular_component	GO:0070652	HAUS complex	"A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]	InterPro
NV2t022854001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022854001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022854001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022855001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t022855001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t022855001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t022855001.1	biological_process	GO:0048490	anterograde synaptic vesicle transport	"The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg]	OMA
NV2t022855001.1	biological_process	GO:0048753	pigment granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]	OMA
NV2t022855001.1	cellular_component	GO:0030117	membrane coat	"Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]	InterPro
NV2t022855001.1	cellular_component	GO:0030123	AP-3 adaptor complex	"A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]	InterPro
NV2t022855001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	OMA
NV2t022855001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t022855001.1	molecular_function	GO:0030742	GTP-dependent protein binding	"Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state." [GOC:go_curators, GOC:krc]	OMA
NV2t022856001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t022856001.1	biological_process	GO:0002090	regulation of receptor internalization	"Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]	OMA
NV2t022856001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	OMA
NV2t022856001.1	biological_process	GO:0016241	regulation of macroautophagy	"Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]	OMA
NV2t022856001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t022856001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t022856001.1	biological_process	GO:0048584	positive regulation of response to stimulus	"Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid]	OMA
NV2t022856001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t022856001.1	biological_process	GO:1900186	negative regulation of clathrin-dependent endocytosis	"Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:TermGenie]	OMA
NV2t022856001.1	biological_process	GO:2000785	regulation of autophagosome assembly	"Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t022856001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022856001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022856001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t022856001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t022856001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t022856002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022856002.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t022856003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022856003.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t022856004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022856004.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t022861001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t022861001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t022861001.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t022861001.1	biological_process	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t022861001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	OMA
NV2t022861001.1	biological_process	GO:1901097	negative regulation of autophagosome maturation	"Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079]	OMA
NV2t022861001.1	biological_process	GO:2000780	negative regulation of double-strand break repair	"Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF]	OMA
NV2t022861001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022861001.1	cellular_component	GO:0005776	autophagosome	"A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]	OMA
NV2t022861001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t022861001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022861001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t022861001.1	cellular_component	GO:0090734	site of DNA damage	"A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg]	OMA
NV2t022861001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022861001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t022861001.1	molecular_function	GO:0036435	K48-linked polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein." [GOC:al, PMID:20739285]	OMA
NV2t022861001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t022863001.1	biological_process	GO:0071526	semaphorin-plexin signaling pathway	"The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]	PANTHER
NV2t022863001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022863002.1	biological_process	GO:0071526	semaphorin-plexin signaling pathway	"The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]	PANTHER
NV2t022863002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022863003.1	biological_process	GO:0071526	semaphorin-plexin signaling pathway	"The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]	PANTHER
NV2t022863003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022870001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t022870001.1	biological_process	GO:0015711	organic anion transport	"The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc]	OMA
NV2t022870001.1	biological_process	GO:0035621	ER to Golgi ceramide transport	"The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229]	PANTHER
NV2t022870001.1	biological_process	GO:0035627	ceramide transport	"The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart]	OMA
NV2t022870001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t022870001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t022870001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022870001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t022870001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t022870001.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	OMA
NV2t022870001.1	molecular_function	GO:0097001	ceramide binding	"Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [GOC:sart]	OMA
NV2t022870001.1	molecular_function	GO:0120014	phospholipid transfer activity	"Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t022870001.1	molecular_function	GO:0120017	ceramide transfer activity	"Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t022870002.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t022870002.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t022870003.1	biological_process	GO:0035621	ER to Golgi ceramide transport	"The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229]	PANTHER
NV2t022870003.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t022870004.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	PANTHER
NV2t022870004.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t022870005.1	biological_process	GO:0035621	ER to Golgi ceramide transport	"The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229]	PANTHER
NV2t022870005.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t022877001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022880002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022880002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022880002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022880003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022880003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022880004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022880004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022880005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022880005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022880006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022880006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t022881001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022881001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022881001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022881001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t022882001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022882001.1	molecular_function	GO:0051119	sugar transmembrane transporter activity	"Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022890001.1	biological_process	GO:0002064	epithelial cell development	"The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]	OMA
NV2t022890001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t022890001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t022890001.1	biological_process	GO:0030048	actin filament-based movement	"Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]	OMA
NV2t022890001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t022890001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t022890001.1	biological_process	GO:0061318	renal filtration cell differentiation	"The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [GOC:dph, GOC:mtg_kidney_jan10]	OMA
NV2t022890001.1	biological_process	GO:0097205	renal filtration	"A renal system process in which fluid circulating through the body is filtered through a barrier system." [GOC:pr, GOC:sart]	OMA
NV2t022890001.1	biological_process	GO:0099518	vesicle cytoskeletal trafficking	"The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl]	OMA
NV2t022890001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022890001.1	cellular_component	GO:0005902	microvillus	"Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194]	OMA
NV2t022890001.1	cellular_component	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	OMA
NV2t022890001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t022890001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t022890001.1	cellular_component	GO:0045334	clathrin-coated endocytic vesicle	"A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]	OMA
NV2t022890001.1	molecular_function	GO:0000146	microfilament motor activity	"A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949]	OMA
NV2t022890001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022890001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t022890001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022890001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t022890001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t022890001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t022890001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t022892001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022892002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022892003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022893001.1	biological_process	GO:0046103	inosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]	PANTHER
NV2t022893001.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	InterPro
NV2t022893002.1	biological_process	GO:0006154	adenosine catabolic process	"The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]	OMA
NV2t022893002.1	biological_process	GO:0034654	nucleobase-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]	OMA
NV2t022893002.1	biological_process	GO:0044283	small molecule biosynthetic process	"The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]	OMA
NV2t022893002.1	biological_process	GO:0046103	inosine biosynthetic process	"The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]	PANTHER
NV2t022893002.1	biological_process	GO:0072522	purine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah]	OMA
NV2t022893002.1	biological_process	GO:1901137	carbohydrate derivative biosynthetic process	"The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t022893002.1	molecular_function	GO:0004000	adenosine deaminase activity	"Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]	OMA
NV2t022893002.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	InterPro
NV2t022900001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t022900001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t022900001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t022900001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022900001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022900001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t022900001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	InterPro
NV2t022900001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	PANTHER
NV2t022900001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t022900001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t022902001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022902001.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	PANTHER
NV2t022902001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022902001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022902002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022902002.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	PANTHER
NV2t022902002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022902002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022902003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022902003.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t022902003.1	biological_process	GO:0034332	adherens junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t022902003.1	biological_process	GO:0042996	regulation of Golgi to plasma membrane protein transport	"Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]	OMA
NV2t022902003.1	biological_process	GO:0050776	regulation of immune response	"Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]	OMA
NV2t022902003.1	biological_process	GO:0051224	negative regulation of protein transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t022902003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022902003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022902003.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t022902003.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	PANTHER
NV2t022902003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022902003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022902003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t022902003.1	molecular_function	GO:0034236	protein kinase A catalytic subunit binding	"Binding to one or both of the catalytic subunits of protein kinase A." [GOC:mah]	OMA
NV2t022902003.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t022902004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022902004.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	PANTHER
NV2t022902004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022902004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022902005.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022902005.1	biological_process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	"Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16835242]	PANTHER
NV2t022902005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022902005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022902006.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022902006.1	biological_process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	"Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16835242]	PANTHER
NV2t022902006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022902006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022902007.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022902007.1	biological_process	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	"Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16835242]	PANTHER
NV2t022902007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022902007.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022902008.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022902008.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	PANTHER
NV2t022902008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022902008.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t022904001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t022904001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t022904001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022904001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t022904001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t022904001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t022904001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022907001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t022907001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t022907001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	OMA
NV2t022907001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t022907001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t022909001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022910001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t022913002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022913002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t022916001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022916001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022916002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022916002.1	biological_process	GO:0042060	wound healing	"The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]	OMA
NV2t022916002.1	biological_process	GO:0048066	developmental pigmentation	"The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089]	OMA
NV2t022916002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t022916002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t022916002.1	biological_process	GO:0050932	regulation of pigment cell differentiation	"Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai]	OMA
NV2t022916002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022916002.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022916002.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t022916002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022917001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t022917001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t022917001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t022917001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t022917001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t022928001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t022928001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022930001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022931001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t022931001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t022931001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022931001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t022932001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t022933001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t022933001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022933001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022938001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022938001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022938002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022938002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022938003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t022938003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022939001.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t022939001.1	biological_process	GO:0006680	glucosylceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]	PANTHER
NV2t022939002.1	biological_process	GO:0006680	glucosylceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]	PANTHER
NV2t022939003.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t022939003.1	biological_process	GO:0006665	sphingolipid metabolic process	"The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	InterPro
NV2t022939003.1	biological_process	GO:0006680	glucosylceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]	PANTHER
NV2t022939003.1	biological_process	GO:0006687	glycosphingolipid metabolic process	"The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]	OMA
NV2t022939003.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t022939003.1	biological_process	GO:0007040	lysosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:0007610	behavior	"The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973]	OMA
NV2t022939003.1	biological_process	GO:0008340	determination of adult lifespan	"The pathways that regulate the duration of the adult phase of the life-cycle of an animal." [PMID:25561524, PMID:273723695, PMID:3424805]	OMA
NV2t022939003.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t022939003.1	biological_process	GO:0030258	lipid modification	"The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:0031329	regulation of cellular catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:0031333	negative regulation of protein-containing complex assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:0032006	regulation of TOR signaling	"Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:0034312	diol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:0035304	regulation of protein dephosphorylation	"Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	OMA
NV2t022939003.1	biological_process	GO:0035306	positive regulation of dephosphorylation	"Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]	OMA
NV2t022939003.1	biological_process	GO:0042176	regulation of protein catabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]	OMA
NV2t022939003.1	biological_process	GO:0042592	homeostatic process	"Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]	OMA
NV2t022939003.1	biological_process	GO:0043243	positive regulation of protein-containing complex disassembly	"Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]	OMA
NV2t022939003.1	biological_process	GO:0043407	negative regulation of MAP kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t022939003.1	biological_process	GO:0046513	ceramide biosynthetic process	"The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]	OMA
NV2t022939003.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t022939003.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	OMA
NV2t022939003.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	OMA
NV2t022939003.1	biological_process	GO:1901136	carbohydrate derivative catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t022939003.1	biological_process	GO:1901215	obsolete negative regulation of neuron death	"OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t022939003.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t022939003.1	biological_process	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	"Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834]	OMA
NV2t022939003.1	biological_process	GO:1903061	positive regulation of protein lipidation	"Any process that activates or increases the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394]	OMA
NV2t022939003.1	biological_process	GO:1904457	positive regulation of neuronal action potential	"Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967]	OMA
NV2t022939003.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t022939003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t022939003.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t022939003.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t022939003.1	molecular_function	GO:0004348	glucosylceramidase activity	"Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]	OMA
NV2t022939003.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t022939003.1	molecular_function	GO:0046527	glucosyltransferase activity	"Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732]	OMA
NV2t022940001.1	molecular_function	GO:0034237	protein kinase A regulatory subunit binding	"Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah]	PANTHER
NV2t022940002.1	molecular_function	GO:0034237	protein kinase A regulatory subunit binding	"Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah]	PANTHER
NV2t022941001.1	biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	"Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]	OMA
NV2t022941001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022941001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t022941001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	PANTHER
NV2t022943002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t022943002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t022944001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t022944001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	InterPro
NV2t022944001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	OMA
NV2t022944001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	PANTHER
NV2t022944001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t022944002.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	InterPro
NV2t022944003.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	InterPro
NV2t022947001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022950001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t022950001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022951001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t022951001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022960001.1	molecular_function	GO:0030983	mismatched DNA binding	"Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah]	InterPro
NV2t022960001.1	molecular_function	GO:0140664	ATP-dependent DNA damage sensor activity	"A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387]	InterPro
NV2t022962001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t022962001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t022962001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t022963001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t022963001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t022963001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t022963001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t022963001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022963001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t022963001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t022963001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t022963001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t022964001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022964001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022964001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022964002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t022966001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t022966001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022967001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022967002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022970001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t022970001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022971001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t022971001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t022971001.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t022971001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t022971001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t022971001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t022971001.1	molecular_function	GO:0004839	ubiquitin activating enzyme activity	"Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme]	OMA
NV2t022971001.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t022971002.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t022971002.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t022971002.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t022971003.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t022971003.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t022971003.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t022971004.1	biological_process	GO:0032446	protein modification by small protein conjugation	"A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]	PANTHER
NV2t022971004.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t022971004.1	molecular_function	GO:0008641	ubiquitin-like modifier activating enzyme activity	"Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]	InterPro
NV2t022974001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t022974001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t022974001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022974001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022975001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t022975001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t022975001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t022982002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022983001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t022984001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022985001.1	cellular_component	GO:0009897	external side of plasma membrane	"The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	OMA
NV2t022985001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022985001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t022992001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022992001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t022992002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022992002.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t022992003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t022992003.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t022994001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	InterPro
NV2t022994001.1	biological_process	GO:0006383	transcription by RNA polymerase III	"The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659]	OMA
NV2t022994001.1	cellular_component	GO:0055029	nuclear DNA-directed RNA polymerase complex	"A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]	OMA
NV2t022994001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t022995001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t022995001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t022995001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t022995001.1	molecular_function	GO:0008242	omega peptidase activity	"Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379]	OMA
NV2t022995001.1	molecular_function	GO:0016920	pyroglutamyl-peptidase activity	"Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [GOC:mah, PMID:9920379]	InterPro
NV2t022997001.1	biological_process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t022997001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t022997001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t022997001.1	molecular_function	GO:0004952	dopamine neurotransmitter receptor activity	"Combining with the neurotransmitter dopamine to initiate a change in cell activity." [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983]	OMA
NV2t022997001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t022999001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t023000001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t023000001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t023000001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t023000001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t023000001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t023000001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t023000001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t023000001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	PANTHER
NV2t023004001.1	biological_process	GO:0035023	regulation of Rho protein signal transduction	"Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]	PANTHER
NV2t023004001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t023004001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t023006001.1	biological_process	GO:1904825	protein localization to microtubule plus-end	"A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:24039245]	PANTHER
NV2t023006001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023006001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t023009001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023009001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023013001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023019001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023019001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t023019001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023022001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023029001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023029001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023031001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023035001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023055001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t023055001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023063001.1	cellular_component	GO:0030687	preribosome, large subunit precursor	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]	PANTHER
NV2t023064001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023064001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023064001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t023064001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t023064001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t023064001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023064001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023064002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023064002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t023064002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t023064002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023066001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023066001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023066001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023067001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023067001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023067001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023067001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023067002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023067002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023067003.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023067003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023073001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023073001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023078001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023078001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023078001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023078001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023083001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t023083001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023083001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023083001.1	molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase." [GOC:ai]	InterPro
NV2t023083001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023083001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t023086001.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	InterPro
NV2t023086001.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	OMA
NV2t023086001.1	biological_process	GO:0006739	NADP metabolic process	"The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	OMA
NV2t023086001.1	biological_process	GO:0006739	NADP metabolic process	"The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]	PANTHER
NV2t023086001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t023086001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t023086001.1	molecular_function	GO:0004450	isocitrate dehydrogenase (NADP+) activity	"Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH." [RHEA:19629]	OMA
NV2t023086001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t023086001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t023089001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t023089001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t023089001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023089001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023089001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023089001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t023091001.1	cellular_component	GO:1990879	CST complex	"A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19854130, PMID:22965356]	PANTHER
NV2t023091001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	InterPro
NV2t023091001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t023092001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t023092001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t023092001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023093001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023093001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023093001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023093002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023093002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023093002.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023093002.1	molecular_function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023093002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023095001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t023095001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t023095001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023095001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t023096001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023096001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023096001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023096001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023098001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t023098001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t023098001.1	cellular_component	GO:0031514	motile cilium	"A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]	OMA
NV2t023099001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023099001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023099001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t023099001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023099001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023101001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023101001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023101001.1	molecular_function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	"Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]	OMA
NV2t023101001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023101001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023103001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023103001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t023103001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t023103001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023103001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023103001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t023103002.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t023103003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023103003.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t023103003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023103004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023103004.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t023103004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023103005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023103005.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t023103005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023108001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t023108001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023108002.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t023108002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023108003.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t023108003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023108004.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t023108004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023110001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t023110001.1	biological_process	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]	OMA
NV2t023110001.1	biological_process	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]	PANTHER
NV2t023110001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t023110001.1	biological_process	GO:0006493	protein O-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]	OMA
NV2t023110001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t023110001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t023110001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t023110001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	InterPro
NV2t023110001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t023110001.1	molecular_function	GO:0004610	phosphoacetylglucosamine mutase activity	"Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23804]	InterPro
NV2t023110001.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	InterPro
NV2t023110001.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	OMA
NV2t023111001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t023111001.1	biological_process	GO:0006264	mitochondrial DNA replication	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]	InterPro
NV2t023111001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t023112001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t023112001.1	biological_process	GO:0006421	asparaginyl-tRNA aminoacylation	"The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t023112002.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t023112002.1	biological_process	GO:0006421	asparaginyl-tRNA aminoacylation	"The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t023112003.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t023112003.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t023112003.1	biological_process	GO:0006421	asparaginyl-tRNA aminoacylation	"The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t023112003.1	biological_process	GO:0006421	asparaginyl-tRNA aminoacylation	"The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t023112003.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t023112003.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t023112003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023112003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023112003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023112003.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t023112003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023112003.1	molecular_function	GO:0042379	chemokine receptor binding	"Binding to a chemokine receptor." [GOC:ai]	OMA
NV2t023112003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t023113001.1	biological_process	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]	PANTHER
NV2t023113001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t023113001.1	molecular_function	GO:0004610	phosphoacetylglucosamine mutase activity	"Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23804]	InterPro
NV2t023113001.1	molecular_function	GO:0016868	intramolecular phosphotransferase activity	"Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]	InterPro
NV2t023114001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	InterPro
NV2t023114001.1	biological_process	GO:0006264	mitochondrial DNA replication	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]	InterPro
NV2t023114001.1	biological_process	GO:0006264	mitochondrial DNA replication	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]	OMA
NV2t023114001.1	cellular_component	GO:0005760	gamma DNA polymerase complex	"A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093]	OMA
NV2t023114001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t023114001.1	molecular_function	GO:0003887	DNA-directed DNA polymerase activity	"Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]	OMA
NV2t023114001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	OMA
NV2t023114001.1	molecular_function	GO:0008408	3'-5' exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]	PANTHER
NV2t023115001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023115001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t023116001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023116001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023116001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023117001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023118001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t023118001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t023118001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t023118001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023118001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023118001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t023118001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	InterPro
NV2t023118001.1	cellular_component	GO:0019773	proteasome core complex, alpha-subunit complex	"The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779]	PANTHER
NV2t023118001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t023118001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t023119001.1	biological_process	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly	"The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]	InterPro
NV2t023120001.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t023120001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t023122001.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t023122001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t023122002.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t023122003.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t023123001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t023124001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t023124001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t023124001.1	biological_process	GO:0071711	basement membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah]	OMA
NV2t023124001.1	biological_process	GO:0090527	obsolete actin filament reorganization	"OBSOLETE. A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments." [GOC:dph, GOC:tb]	OMA
NV2t023124001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t023124001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023124001.1	cellular_component	GO:0005927	muscle tendon junction	"A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]	OMA
NV2t023124001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023124001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023124002.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	PANTHER
NV2t023125001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t023125001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t023125001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t023125001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023127001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023127001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t023127001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023127001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t023129001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023129001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t023130001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t023130001.1	molecular_function	GO:0016853	isomerase activity	"Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]	InterPro
NV2t023130001.1	molecular_function	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]	OMA
NV2t023130001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t023130001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t023130001.1	molecular_function	GO:0047938	glucose-6-phosphate 1-epimerase activity	"Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN]	PANTHER
NV2t023131001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023133001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023133001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	PANTHER
NV2t023134001.1	biological_process	GO:0032793	positive regulation of CREB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]	OMA
NV2t023134001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023134001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	InterPro
NV2t023134001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t023134001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023134001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023134001.1	molecular_function	GO:0008140	cAMP response element binding protein binding	"Binding to a cAMP response element binding protein (a CREB protein)." [GOC:mah]	OMA
NV2t023134002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023135001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t023135001.1	biological_process	GO:1903479	mitotic actomyosin contractile ring assembly actin filament organization	"Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t023135001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023135002.1	biological_process	GO:0007173	epidermal growth factor receptor signaling pathway	"The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	OMA
NV2t023135002.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t023135002.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t023135002.1	biological_process	GO:0032956	regulation of actin cytoskeleton organization	"Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]	OMA
NV2t023135002.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t023135002.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t023135002.1	biological_process	GO:0045860	positive regulation of protein kinase activity	"Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]	OMA
NV2t023135002.1	biological_process	GO:0051592	response to calcium ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]	OMA
NV2t023135002.1	biological_process	GO:0071248	cellular response to metal ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]	OMA
NV2t023135002.1	biological_process	GO:0071364	cellular response to epidermal growth factor stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]	OMA
NV2t023135002.1	biological_process	GO:1901701	cellular response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t023135002.1	biological_process	GO:1902075	cellular response to salt	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921]	OMA
NV2t023135002.1	biological_process	GO:1903479	mitotic actomyosin contractile ring assembly actin filament organization	"Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t023135002.1	biological_process	GO:1990138	neuron projection extension	"Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009]	OMA
NV2t023135002.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t023135002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023135002.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t023135002.1	cellular_component	GO:0005911	cell-cell junction	"A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264]	OMA
NV2t023135002.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t023135002.1	cellular_component	GO:0030426	growth cone	"The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]	OMA
NV2t023135002.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t023135002.1	cellular_component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	"The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah]	OMA
NV2t023135002.1	cellular_component	GO:0036464	cytoplasmic ribonucleoprotein granule	"A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898]	OMA
NV2t023135002.1	molecular_function	GO:0005078	MAP-kinase scaffold activity	"The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336]	OMA
NV2t023135002.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t023135002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023135002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023135002.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t023135002.1	molecular_function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	"Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]	OMA
NV2t023135002.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t023135002.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t023135002.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t023135002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t023135002.1	molecular_function	GO:0043539	protein serine/threonine kinase activator activity	"Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators]	OMA
NV2t023135002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t023136001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023136001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023136001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023138001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023138001.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	InterPro
NV2t023138001.1	biological_process	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	PANTHER
NV2t023138001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023138002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023138002.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	InterPro
NV2t023138002.1	biological_process	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	PANTHER
NV2t023138002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023138003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023138003.1	biological_process	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	"The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]	InterPro
NV2t023138003.1	biological_process	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	PANTHER
NV2t023138003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023139001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t023139001.1	biological_process	GO:0036297	interstrand cross-link repair	"Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]	OMA
NV2t023139001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023139001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023139001.1	molecular_function	GO:0004527	exonuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]	OMA
NV2t023139001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t023139001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t023139001.1	molecular_function	GO:0070336	flap-structured DNA binding	"Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154]	PANTHER
NV2t023144001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t023144001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023144001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t023144001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t023144001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t023144001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t023144001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023144001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t023144001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t023144001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023144002.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t023144002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023144002.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t023144002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t023144002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023144003.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t023144003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023144003.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t023144003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t023144003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023145001.1	biological_process	GO:0006182	cGMP biosynthetic process	"The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732]	InterPro
NV2t023145001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023145001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t023145001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t023145001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t023145001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t023145001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023145001.1	molecular_function	GO:0004383	guanylate cyclase activity	"Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]	OMA
NV2t023145001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t023145001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023147001.1	biological_process	GO:0007168	receptor guanylyl cyclase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030]	PANTHER
NV2t023147001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t023154001.1	molecular_function	GO:1902936	phosphatidylinositol bisphosphate binding	"Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]	PANTHER
NV2t023155001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t023155001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t023155001.1	biological_process	GO:0010212	response to ionizing radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]	OMA
NV2t023155001.1	biological_process	GO:0030174	regulation of DNA-templated DNA replication initiation	"Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah]	OMA
NV2t023155001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	InterPro
NV2t023155001.1	biological_process	GO:0033314	mitotic DNA replication checkpoint signaling	"A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle]	OMA
NV2t023155001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023155001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t023156001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t023156001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023156002.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t023156002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023156003.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t023156003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023157001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023158001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023158001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023164001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023164002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t023164002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023164002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t023165001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t023168001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	OMA
NV2t023168001.1	biological_process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	"Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators]	OMA
NV2t023168001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t023168001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023168001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t023168001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	InterPro
NV2t023168001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	OMA
NV2t023168001.1	molecular_function	GO:0097602	cullin family protein binding	"Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375]	PANTHER
NV2t023171001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023172001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t023172001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t023175001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t023175002.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t023175002.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t023175002.1	biological_process	GO:0036158	outer dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t023175002.1	cellular_component	GO:0005858	axonemal dynein complex	"A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194]	OMA
NV2t023175002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023175002.1	molecular_function	GO:0045503	dynein light chain binding	"Binding to a light chain of the dynein complex." [GOC:bf]	OMA
NV2t023175002.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	OMA
NV2t023175002.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t023175003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023175003.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t023175004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023175004.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t023175005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023175005.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t023175006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023175006.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t023177001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023179001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023179001.1	molecular_function	GO:0045504	dynein heavy chain binding	"Binding to a heavy chain of the dynein complex." [GOC:bf]	PANTHER
NV2t023181001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t023181001.1	biological_process	GO:0006858	extracellular transport	"The transport of substances that occurs outside cells." [GOC:go_curators]	OMA
NV2t023181001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t023181001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t023181001.1	biological_process	GO:0099111	microtubule-based transport	"A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	OMA
NV2t023181001.1	cellular_component	GO:0005881	cytoplasmic microtubule	"Any microtubule in the cytoplasm of a cell." [GOC:mah]	OMA
NV2t023181001.1	cellular_component	GO:0005930	axoneme	"The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684]	OMA
NV2t023185001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023185002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023186001.1	cellular_component	GO:0000922	spindle pole	"Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]	OMA
NV2t023186001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023186001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t023186001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023186001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023186001.1	molecular_function	GO:0008568	microtubule severing ATPase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [PMID:10910766]	OMA
NV2t023186001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023186001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t023186001.1	molecular_function	GO:0140603	obsolete ATP hydrolysis activity	"OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [GOC:curators]	PANTHER
NV2t023187001.1	molecular_function	GO:0019202	amino acid kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]	PANTHER
NV2t023188001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	InterPro
NV2t023188001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t023188001.1	biological_process	GO:0016539	intein-mediated protein splicing	"The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]	InterPro
NV2t023188001.1	biological_process	GO:0016540	protein autoprocessing	"Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]	InterPro
NV2t023194001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	InterPro
NV2t023194001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t023194001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023195001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t023195001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t023195001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t023196001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t023196001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023205001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t023215001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023215001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t023215001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023215002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023215002.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t023215003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023215003.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t023215003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023218001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023218001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t023218001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023218002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023218002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t023218002.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t023218002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t023218002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023218002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023225001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023225001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023225001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023225001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t023225001.1	molecular_function	GO:0047974	guanosine deaminase activity	"Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]	PANTHER
NV2t023225002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023225002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023225002.1	molecular_function	GO:0047974	guanosine deaminase activity	"Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]	PANTHER
NV2t023225003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023225003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023225003.1	molecular_function	GO:0047974	guanosine deaminase activity	"Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]	PANTHER
NV2t023228001.1	biological_process	GO:0006152	purine nucleoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators]	OMA
NV2t023228001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023228001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023228001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023228001.1	molecular_function	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]	OMA
NV2t023228001.1	molecular_function	GO:0019239	deaminase activity	"Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl]	OMA
NV2t023228001.1	molecular_function	GO:0047974	guanosine deaminase activity	"Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]	PANTHER
NV2t023229001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t023229001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023229001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023229002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023229003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023229003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023230001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023230001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023235001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t023235001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023235001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023235001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023237001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t023237001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t023237001.1	cellular_component	GO:0015630	microtubule cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]	OMA
NV2t023237001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	InterPro
NV2t023237001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	OMA
NV2t023238001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t023238001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t023239001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023240001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t023240001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t023241001.1	biological_process	GO:0007035	vacuolar acidification	"Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid]	OMA
NV2t023241001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t023241001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023241001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t023241001.1	cellular_component	GO:0043291	RAVE complex	"A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802]	PANTHER
NV2t023241001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023242001.1	molecular_function	GO:0016432	tRNA-uridine aminocarboxypropyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25]	OMA
NV2t023244001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023245001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023245002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023247001.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t023247001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023247001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t023247002.1	cellular_component	GO:0090575	RNA polymerase II transcription regulator complex	"A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb]	PANTHER
NV2t023247002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023247002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t023248001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t023248001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t023248001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023248001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023248001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t023248001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t023250001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023250001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023251001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023251001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023251001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023251001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023251001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023251002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023251002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023252001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023252001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t023252001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t023252001.1	biological_process	GO:0046777	protein autophosphorylation	"The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732]	OMA
NV2t023252001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023252001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023252001.1	molecular_function	GO:0004683	calmodulin-dependent protein kinase activity	"Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah, PMID:11264466]	OMA
NV2t023252001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t023252001.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t023252001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023252001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023252002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023252002.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t023252003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023252003.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t023252004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023252004.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	PANTHER
NV2t023252004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023254001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t023255001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t023255001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023255002.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t023255002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023257001.1	biological_process	GO:0034972	obsolete histone H3-R26 methylation	"OBSOLETE. The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]	PANTHER
NV2t023257001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023258001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023262001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023262001.1	molecular_function	GO:0070034	telomerase RNA binding	"Binding to the telomerase RNA template." [GOC:krc, PMID:16884717]	PANTHER
NV2t023264001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264001.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264002.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264003.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264004.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264005.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t023264006.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264006.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023264006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264007.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264007.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264008.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264008.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264009.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264009.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264010.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264010.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264010.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264011.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264011.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264011.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264012.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264012.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264012.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023264013.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023264013.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	PANTHER
NV2t023264013.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023269001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t023269001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023269001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	InterPro
NV2t023269001.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t023269002.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t023269002.1	biological_process	GO:0045332	phospholipid translocation	"The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]	OMA
NV2t023269002.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t023269002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023269002.1	cellular_component	GO:1990351	transporter complex	"A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578]	OMA
NV2t023269002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t023269002.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t023269002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023269002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023269002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t023269002.1	molecular_function	GO:0140303	intramembrane lipid transporter activity	"Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084]	OMA
NV2t023269002.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	InterPro
NV2t023269002.1	molecular_function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	"Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084]	PANTHER
NV2t023270001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023271001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023272001.1	biological_process	GO:0006869	lipid transport	"The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]	InterPro
NV2t023274001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023274001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023275001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023275001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023275001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t023275001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t023275001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t023275001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t023275001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t023276001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t023276001.1	biological_process	GO:0007194	negative regulation of adenylate cyclase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t023276001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023276001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023276001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023277001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023277001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023278001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023278001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023279001.1	biological_process	GO:0007194	negative regulation of adenylate cyclase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t023279001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023279001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023279001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023279002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023279002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023279003.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t023279003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023280001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023280001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t023280001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023280001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023282001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t023282001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023282001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t023282001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t023285001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t023288001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023288001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t023292001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023292001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t023292001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t023292001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023292001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t023292001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023293001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t023293001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023293002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023295001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023295001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023295002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023295002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023301002.1	cellular_component	GO:0009898	cytoplasmic side of plasma membrane	"The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb]	PANTHER
NV2t023302001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	OMA
NV2t023302001.1	molecular_function	GO:0004035	alkaline phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]	OMA
NV2t023302001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t023304001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023304001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	PANTHER
NV2t023306001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t023306001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t023306001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t023306001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t023306001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t023306001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t023306001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t023307001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023307001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023307002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023307002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023307003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023307003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023307004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023307004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023308001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	InterPro
NV2t023308001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t023308001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023309001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023309002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023309003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023310001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t023310001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t023310001.1	biological_process	GO:0051099	positive regulation of binding	"Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]	OMA
NV2t023310001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023310001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	OMA
NV2t023310001.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	PANTHER
NV2t023310001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t023310001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023310001.1	molecular_function	GO:0017022	myosin binding	"Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah]	OMA
NV2t023310001.1	molecular_function	GO:0035613	RNA stem-loop binding	"Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544]	OMA
NV2t023310001.1	molecular_function	GO:0048027	mRNA 5'-UTR binding	"Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid]	OMA
NV2t023310001.1	molecular_function	GO:1990825	sequence-specific mRNA binding	"Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]	OMA
NV2t023310002.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	PANTHER
NV2t023310002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t023310002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023310003.1	cellular_component	GO:0005844	obsolete polysome	"OBSOLETE. A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871]	PANTHER
NV2t023310003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t023310003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023313001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023313001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023313001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023316001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023316001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023317001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t023317001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t023317001.1	biological_process	GO:0002757	immune response-activating signaling pathway	"The series of molecular signals generated by a ligand binding to its receptor that lead to the activation or perpetuation of an immune response." [GOC:add]	OMA
NV2t023317001.1	biological_process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]	OMA
NV2t023317001.1	biological_process	GO:0006119	oxidative phosphorylation	"The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309]	OMA
NV2t023317001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t023317001.1	biological_process	GO:0006851	mitochondrial calcium ion transmembrane transport	"The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai]	OMA
NV2t023317001.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t023317001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	PANTHER
NV2t023317001.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	OMA
NV2t023317001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t023317001.1	biological_process	GO:0010876	lipid localization	"Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t023317001.1	biological_process	GO:0010918	positive regulation of mitochondrial membrane potential	"Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb]	OMA
NV2t023317001.1	biological_process	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t023317001.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	OMA
NV2t023317001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t023317001.1	biological_process	GO:0051259	protein complex oligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929]	OMA
NV2t023317001.1	biological_process	GO:0090297	positive regulation of mitochondrial DNA replication	"Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb]	OMA
NV2t023317001.1	biological_process	GO:1903727	positive regulation of phospholipid metabolic process	"Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240]	OMA
NV2t023317001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t023317001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t023317001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t023317001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023317001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t023317001.1	cellular_component	GO:0098802	plasma membrane signaling receptor complex	"Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos]	OMA
NV2t023317001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t023317001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t023317001.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	OMA
NV2t023318001.1	molecular_function	GO:0008134	transcription factor binding	"Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732]	InterPro
NV2t023318001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t023319001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023319001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t023319001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023321001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t023321001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t023321001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t023321001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t023321002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	PANTHER
NV2t023323001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t023323001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t023323001.1	cellular_component	GO:0030677	ribonuclease P complex	"A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]	OMA
NV2t023323001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023323001.1	molecular_function	GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	"Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]	OMA
NV2t023323001.1	molecular_function	GO:0033204	ribonuclease P RNA binding	"Binding to RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963]	PANTHER
NV2t023323001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t023325001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t023325001.1	biological_process	GO:1902749	regulation of cell cycle G2/M phase transition	"Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie]	OMA
NV2t023325001.1	cellular_component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	"Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]	OMA
NV2t023325001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023325001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	InterPro
NV2t023325001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	OMA
NV2t023325002.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	InterPro
NV2t023328001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t023328001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023328001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023328001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023328001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t023328001.1	molecular_function	GO:0005432	calcium:sodium antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]	OMA
NV2t023328002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023328002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023328002.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t023328003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023328003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023328003.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t023329001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t023329001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023329001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t023329001.1	biological_process	GO:0016573	obsolete histone acetylation	"OBSOLETE. The modification of a histone by the addition of an acetyl group." [GOC:ai]	OMA
NV2t023329001.1	cellular_component	GO:0032783	super elongation complex	"A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae." [PMID:17150956, PMID:30102332]	OMA
NV2t023329001.1	cellular_component	GO:0035267	NuA4 histone acetyltransferase complex	"A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]	OMA
NV2t023329001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t023329001.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t023330001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023331002.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t023331003.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t023331004.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t023331005.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t023331006.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t023331007.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t023331008.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t023331009.1	cellular_component	GO:0140268	endoplasmic reticulum-plasma membrane contact site	"A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]	PANTHER
NV2t023332001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023332001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023333001.1	biological_process	GO:0006777	Mo-molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473]	InterPro
NV2t023333001.1	biological_process	GO:0032324	molybdopterin cofactor biosynthetic process	"The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]	OMA
NV2t023333001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023333001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t023333001.1	cellular_component	GO:0019008	molybdopterin synthase complex	"A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772]	OMA
NV2t023333001.1	molecular_function	GO:0016783	sulfurtransferase activity	"Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544]	OMA
NV2t023333001.1	molecular_function	GO:0030366	molybdopterin synthase activity	"Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783]	InterPro
NV2t023334001.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t023334001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023334001.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t023334001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023334002.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t023334002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023334002.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t023334002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023334003.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t023334003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023334003.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t023334003.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t023334003.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t023334003.1	molecular_function	GO:0005248	voltage-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023334003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023334004.1	biological_process	GO:0006814	sodium ion transport	"The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t023334004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023334004.1	biological_process	GO:0086010	membrane depolarization during action potential	"The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]	PANTHER
NV2t023334004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023335001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t023335001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t023335001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t023335001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t023338001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023338001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023338001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023338001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t023338001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023338001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t023338001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023339001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023339001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023339001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023339001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t023339001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023339001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t023339001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023340001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023340001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023340001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t023340001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023340001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t023340001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023340001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t023340001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023342001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	OMA
NV2t023342001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	InterPro
NV2t023342001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t023343001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t023343001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023344001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t023344001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023344001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t023345001.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	InterPro
NV2t023345001.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	OMA
NV2t023345001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t023345001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023345002.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	InterPro
NV2t023345002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023345003.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	InterPro
NV2t023345003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023345004.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	InterPro
NV2t023345004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023346001.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	OMA
NV2t023346001.1	biological_process	GO:0016559	peroxisome fission	"The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]	InterPro
NV2t023346001.1	biological_process	GO:0016559	peroxisome fission	"The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]	PANTHER
NV2t023346001.1	biological_process	GO:0048285	organelle fission	"The creation of two or more organelles by division of one organelle." [GOC:jid]	OMA
NV2t023347001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	OMA
NV2t023347001.1	biological_process	GO:0019941	modification-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]	OMA
NV2t023347001.1	biological_process	GO:0034612	response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	OMA
NV2t023347001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023347001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023347001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t023347001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023347001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t023347001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t023347001.1	molecular_function	GO:0070628	proteasome binding	"Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]	OMA
NV2t023350001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023350001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023353001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023353001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023353001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023353002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023353002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023357001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023357001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023359001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023359001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t023359001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023359001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023359001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t023362001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023364001.1	biological_process	GO:0085020	protein K6-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]	PANTHER
NV2t023364001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023364002.1	biological_process	GO:0085020	protein K6-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]	PANTHER
NV2t023364002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023364003.1	biological_process	GO:0085020	protein K6-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp]	PANTHER
NV2t023364003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023366001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023366001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t023366001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t023366001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t023366001.1	biological_process	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t023366001.1	biological_process	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	OMA
NV2t023366001.1	biological_process	GO:0048513	animal organ development	"Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid]	OMA
NV2t023366001.1	biological_process	GO:0048523	negative regulation of cellular process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid]	OMA
NV2t023366001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023366001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	OMA
NV2t023366001.1	molecular_function	GO:0004708	MAP kinase kinase activity	"Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684]	OMA
NV2t023366001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023366001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023366001.1	molecular_function	GO:0097110	scaffold protein binding	"Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes." [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]	OMA
NV2t023366002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023367001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t023367001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	OMA
NV2t023367001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t023367001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t023367001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t023367001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t023367001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t023370001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023371001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023371002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023372001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023374001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023375001.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	InterPro
NV2t023375001.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	PANTHER
NV2t023380001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023380001.1	biological_process	GO:0007216	G protein-coupled glutamate receptor signaling pathway	"A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, GOC:signaling, PMID:9131252]	OMA
NV2t023380001.1	biological_process	GO:2001256	regulation of store-operated calcium entry	"Any process that modulates the frequency, rate or extent of store-operated calcium entry." [GOC:BHF]	PANTHER
NV2t023380001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t023380001.1	molecular_function	GO:0035256	G protein-coupled glutamate receptor binding	"Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor)." [GOC:bf, ISBN:0198506732, PMID:9069287]	InterPro
NV2t023382001.1	biological_process	GO:0022008	neurogenesis	"Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]	PANTHER
NV2t023382001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023383001.1	biological_process	GO:0042796	snRNA transcription by RNA polymerase III	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t023384001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t023384001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t023384001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t023384001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t023384001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t023385001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t023385001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t023385001.1	biological_process	GO:0044249	cellular biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]	OMA
NV2t023385001.1	biological_process	GO:0048872	homeostasis of number of cells	"Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]	OMA
NV2t023385001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023385001.1	biological_process	GO:1901566	organonitrogen compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t023385001.1	biological_process	GO:1904983	glycine import into mitochondrion	"The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380]	InterPro
NV2t023385001.1	biological_process	GO:1904983	glycine import into mitochondrion	"The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380]	PANTHER
NV2t023385001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t023385001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t023385001.1	molecular_function	GO:0015187	glycine transmembrane transporter activity	"Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai]	OMA
NV2t023385002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023385002.1	biological_process	GO:1904983	glycine import into mitochondrion	"The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380]	InterPro
NV2t023385002.1	biological_process	GO:1904983	glycine import into mitochondrion	"The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380]	PANTHER
NV2t023387001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	PANTHER
NV2t023387001.1	cellular_component	GO:0000444	MIS12/MIND type complex	"A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270]	InterPro
NV2t023387002.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	PANTHER
NV2t023387002.1	cellular_component	GO:0000444	MIS12/MIND type complex	"A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270]	InterPro
NV2t023387003.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t023387003.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	PANTHER
NV2t023387003.1	cellular_component	GO:0000444	MIS12/MIND type complex	"A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270]	InterPro
NV2t023387003.1	cellular_component	GO:0000939	inner kinetochore	"The region of a kinetochore closest to centromeric DNA which contains many CENP proteins organized in various subcomplexes including CENP-C, CENP-LN, CENP-HIKM, CENP-OPQUR and CENP-TWSX, but excluding the CENP-A containing heterochromatin." [GOC:clt, PMID:10619130, PMID:11483983, PMID:32516549]	OMA
NV2t023388001.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	InterPro
NV2t023388001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t023388001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	PANTHER
NV2t023388002.1	biological_process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732]	InterPro
NV2t023388002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t023388002.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	PANTHER
NV2t023388003.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t023388003.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	PANTHER
NV2t023389001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t023389001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023389001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023389001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023390001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	PANTHER
NV2t023390001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t023392001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t023392001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t023392001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023393001.1	biological_process	GO:0006596	polyamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732]	OMA
NV2t023393001.1	biological_process	GO:0009446	putrescine biosynthetic process	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t023393001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t023393001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t023393001.1	molecular_function	GO:0047632	agmatine deiminase activity	"Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]	PANTHER
NV2t023395001.1	biological_process	GO:0009446	putrescine biosynthetic process	"The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732]	InterPro
NV2t023395001.1	molecular_function	GO:0047632	agmatine deiminase activity	"Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]	PANTHER
NV2t023396001.1	biological_process	GO:0050982	detection of mechanical stimulus	"The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	PANTHER
NV2t023396001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023399001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023400001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023400001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023402001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023402001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023402001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023402001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023402002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023402002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023403001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023404001.1	biological_process	GO:0018095	protein polyglutamylation	"The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202]	InterPro
NV2t023406001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	InterPro
NV2t023406001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	OMA
NV2t023406001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t023407001.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t023407001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t023407002.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t023407002.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t023407003.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	InterPro
NV2t023407003.1	biological_process	GO:0016055	Wnt signaling pathway	"The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state." [PMID:11532397]	OMA
NV2t023407003.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t023407003.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t023407003.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t023410001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410002.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410003.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410003.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410004.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410004.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410005.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410005.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410006.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410006.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410007.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410007.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410008.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410008.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410009.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410009.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410010.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410010.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410011.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410011.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410012.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410012.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410013.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t023410013.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410013.1	molecular_function	GO:0003746	translation elongation factor activity	"Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]	OMA
NV2t023410013.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t023410013.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023410013.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t023410013.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t023410014.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t023410014.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023412001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023415001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t023415001.1	biological_process	GO:0050728	negative regulation of inflammatory response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]	OMA
NV2t023415001.1	biological_process	GO:0051438	regulation of ubiquitin-protein transferase activity	"Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb]	OMA
NV2t023415001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023415001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t023415001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t023415001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t023415001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023415001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	OMA
NV2t023417001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	OMA
NV2t023417001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t023419001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	OMA
NV2t023419001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	PANTHER
NV2t023419001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t023419001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t023421001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023421001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023421001.1	molecular_function	GO:0008188	neuropeptide receptor activity	"Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]	OMA
NV2t023421002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023421003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023421004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023421005.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023421006.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023421007.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421007.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023421008.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421008.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023421009.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023421009.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023422001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023422001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t023429001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t023429001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t023429001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t023431001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t023431001.1	molecular_function	GO:0017108	5'-flap endonuclease activity	"Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]	OMA
NV2t023433001.1	biological_process	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	OMA
NV2t023433001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023433001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t023433001.1	biological_process	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t023433001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023433001.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t023433001.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	OMA
NV2t023435001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t023435001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023435001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t023435001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023435001.1	molecular_function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	"Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+." [GOC:ai, RHEA:25277]	OMA
NV2t023435001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t023435002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023435002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023435002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t023435003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023435003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023435003.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t023435004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023435004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023435004.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t023435005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023435005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023435005.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t023435006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023435006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023435006.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t023436001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023436001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023436001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023438001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023438001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023438001.1	molecular_function	GO:0019789	SUMO transferase activity	"Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250]	OMA
NV2t023438001.1	molecular_function	GO:0061665	SUMO ligase activity	"Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate." [GOC:dph]	PANTHER
NV2t023442001.1	biological_process	GO:0005977	glycogen metabolic process	"The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732]	OMA
NV2t023442001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t023442001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t023442001.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	OMA
NV2t023442001.1	biological_process	GO:0045936	negative regulation of phosphate metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]	OMA
NV2t023442001.1	biological_process	GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	"OBSOLETE. The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it." [ISBN:0198506732]	OMA
NV2t023442001.1	biological_process	GO:0050790	regulation of catalytic activity	"Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw]	OMA
NV2t023442001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023442001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023442001.1	cellular_component	GO:0005791	rough endoplasmic reticulum	"The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732]	OMA
NV2t023442001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023442001.1	cellular_component	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	"The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos]	OMA
NV2t023442001.1	cellular_component	GO:0098588	bounding membrane of organelle	"The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos]	OMA
NV2t023442001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t023442001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t023442001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t023442001.1	molecular_function	GO:0019203	carbohydrate phosphatase activity	"Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah]	InterPro
NV2t023442001.1	molecular_function	GO:0019203	carbohydrate phosphatase activity	"Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah]	OMA
NV2t023442001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t023442001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t023442001.1	molecular_function	GO:2001069	glycogen binding	"Binding to glycogen." [GOC:mengo_curators]	OMA
NV2t023442001.1	molecular_function	GO:2001070	starch binding	"Binding to starch." [GOC:mengo_curators]	InterPro
NV2t023443001.1	biological_process	GO:0035610	protein side chain deglutamylation	"The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048]	PANTHER
NV2t023443001.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	InterPro
NV2t023443001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023443002.1	biological_process	GO:0001754	eye photoreceptor cell differentiation	"The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]	OMA
NV2t023443002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023443002.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t023443002.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t023443002.1	biological_process	GO:0018200	peptidyl-glutamic acid modification	"The modification of peptidyl-glutamic acid." [GOC:go_curators]	OMA
NV2t023443002.1	biological_process	GO:0018410	C-terminal protein amino acid modification	"The alteration of the C-terminal amino acid residue in a protein." [GOC:mah]	OMA
NV2t023443002.1	biological_process	GO:0021953	central nervous system neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t023443002.1	biological_process	GO:0035610	protein side chain deglutamylation	"The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048]	PANTHER
NV2t023443002.1	biological_process	GO:0048646	anatomical structure formation involved in morphogenesis	"The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb]	OMA
NV2t023443002.1	biological_process	GO:0050905	neuromuscular process	"Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]	OMA
NV2t023443002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023443002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t023443002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023443002.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	InterPro
NV2t023443002.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t023443002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023443002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023443002.1	molecular_function	GO:0015631	tubulin binding	"Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]	OMA
NV2t023443003.1	biological_process	GO:0035610	protein side chain deglutamylation	"The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048]	PANTHER
NV2t023443003.1	molecular_function	GO:0004181	metallocarboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	InterPro
NV2t023443003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023444001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t023444001.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t023444001.1	biological_process	GO:0106035	protein maturation by [4Fe-4S] cluster transfer	"The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]	InterPro
NV2t023444001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t023445001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023445001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t023445001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t023445001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t023445001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	OMA
NV2t023445001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	PANTHER
NV2t023445001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023445001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023445001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t023445001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t023445001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023445001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023449001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023449001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023449001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	PANTHER
NV2t023449001.1	molecular_function	GO:0005247	voltage-gated chloride channel activity	"Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023451001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023451001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023451001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023451001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t023452001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023452002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023452003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023452003.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t023452003.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t023452003.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t023454001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023454001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023454001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023455001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023456001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t023456001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	PANTHER
NV2t023456001.1	cellular_component	GO:0000813	ESCRT I complex	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]	OMA
NV2t023456001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t023457001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023457001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023457002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023457002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t023457002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023459001.1	molecular_function	GO:0035197	siRNA binding	"Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283]	PANTHER
NV2t023460001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023460001.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t023460001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023460001.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t023463001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023463002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023467001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023467001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t023467001.1	biological_process	GO:0061668	mitochondrial ribosome assembly	"The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph]	OMA
NV2t023467001.1	biological_process	GO:0061668	mitochondrial ribosome assembly	"The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph]	PANTHER
NV2t023467001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t023467001.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t023469001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t023469001.1	biological_process	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]	InterPro
NV2t023469001.1	biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	"The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]	OMA
NV2t023469001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	OMA
NV2t023469001.1	cellular_component	GO:0030126	COPI vesicle coat	"One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]	PANTHER
NV2t023469001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t023469001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023470001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t023470001.1	biological_process	GO:0015986	proton motive force-driven ATP synthesis	"The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]	InterPro
NV2t023470001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t023470001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	OMA
NV2t023470001.1	cellular_component	GO:0045259	proton-transporting ATP synthase complex	"A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663]	OMA
NV2t023470001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023470001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023470001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023470001.1	molecular_function	GO:0016874	ligase activity	"Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah]	OMA
NV2t023470001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	InterPro
NV2t023470001.1	molecular_function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	"Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57722]	InterPro
NV2t023471001.1	biological_process	GO:0000105	histidine biosynthetic process	"The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]	InterPro
NV2t023471001.1	biological_process	GO:0008652	amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732]	OMA
NV2t023471001.1	molecular_function	GO:0000107	imidazoleglycerol-phosphate synthase activity	"Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+." [RHEA:24793]	InterPro
NV2t023471001.1	molecular_function	GO:0000107	imidazoleglycerol-phosphate synthase activity	"Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+." [RHEA:24793]	PANTHER
NV2t023471001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t023471001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t023471001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t023471001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t023473001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t023473001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t023473001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023473001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023473001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023473001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023474001.1	biological_process	GO:0003254	regulation of membrane depolarization	"Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]	OMA
NV2t023474001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	OMA
NV2t023474001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023474001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t023474001.1	cellular_component	GO:0098855	HCN channel complex	"A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart." [PMID:20829353]	PANTHER
NV2t023474001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023475001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t023475001.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t023475001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023475001.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023475002.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023475003.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023475004.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023475005.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023475006.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023476001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023476001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023476001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023476001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t023477001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023477001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023477001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023477001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t023478002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t023478002.1	biological_process	GO:0007411	axon guidance	"The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]	OMA
NV2t023478002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023478002.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023478003.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023478004.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023479001.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023480001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t023480001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023481001.1	molecular_function	GO:0098632	cell-cell adhesion mediator activity	"The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion]	PANTHER
NV2t023482001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t023482001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023484001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023487001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023487001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t023487001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023487002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023487003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023489001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023489001.1	cellular_component	GO:0030140	trans-Golgi network transport vesicle	"A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]	OMA
NV2t023489001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t023497001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023498001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t023498001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t023498001.1	biological_process	GO:0006363	termination of RNA polymerase I transcription	"A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit." [GOC:mah, GOC:txnOH, PMID:10684922, PMID:27371117]	PANTHER
NV2t023498001.1	biological_process	GO:0016071	mRNA metabolic process	"The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	OMA
NV2t023498001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t023498001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023498001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023498001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023501001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023503001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t023503001.1	cellular_component	GO:0005666	RNA polymerase III complex	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t023503002.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t023503002.1	cellular_component	GO:0005666	RNA polymerase III complex	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t023504001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	OMA
NV2t023504001.1	biological_process	GO:0006363	termination of RNA polymerase I transcription	"A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit." [GOC:mah, GOC:txnOH, PMID:10684922, PMID:27371117]	PANTHER
NV2t023504001.1	biological_process	GO:0016071	mRNA metabolic process	"The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732]	OMA
NV2t023504001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t023504001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023504001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023504001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023506001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023506001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t023508001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t023508001.1	cellular_component	GO:0005666	RNA polymerase III complex	"RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t023512001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023512001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023512002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023512002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023512003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023512003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023512004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023512004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023512004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023512004.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023515001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t023515001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t023515001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023515001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023515001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023516001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t023516001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t023516001.1	biological_process	GO:0009150	purine ribonucleotide metabolic process	"The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t023516001.1	biological_process	GO:0015936	coenzyme A metabolic process	"The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	InterPro
NV2t023516001.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	PANTHER
NV2t023516001.1	biological_process	GO:0033875	ribonucleoside bisphosphate metabolic process	"The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t023516001.1	biological_process	GO:0034032	purine nucleoside bisphosphate metabolic process	"The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t023516001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t023516001.1	molecular_function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	"Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH." [PMID:29224355, RHEA:15989]	InterPro
NV2t023516001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t023516001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t023516001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t023516001.1	molecular_function	GO:0050661	NADP binding	"Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]	InterPro
NV2t023516002.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t023516002.1	biological_process	GO:0015936	coenzyme A metabolic process	"The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]	InterPro
NV2t023516002.1	biological_process	GO:0016126	sterol biosynthetic process	"The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]	PANTHER
NV2t023516002.1	molecular_function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	"Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH." [PMID:29224355, RHEA:15989]	InterPro
NV2t023516002.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	InterPro
NV2t023517001.1	biological_process	GO:0051321	meiotic cell cycle	"Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]	PANTHER
NV2t023517001.1	molecular_function	GO:0043015	gamma-tubulin binding	"Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl]	InterPro
NV2t023518001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023518001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t023518001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t023518001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t023519001.1	molecular_function	GO:1990756	ubiquitin-like ligase-substrate adaptor activity	"The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]	PANTHER
NV2t023520001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t023520001.1	biological_process	GO:0018195	peptidyl-arginine modification	"The modification of peptidyl-arginine." [GOC:go_curators]	OMA
NV2t023520001.1	biological_process	GO:0042543	protein N-linked glycosylation via arginine	"The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine." [RESID:AA0327]	PANTHER
NV2t023521001.1	biological_process	GO:0009566	fertilization	"The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732]	OMA
NV2t023521001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t023521001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	OMA
NV2t023521001.1	biological_process	GO:0048240	sperm capacitation	"A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818]	PANTHER
NV2t023521001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023521001.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t023521001.1	molecular_function	GO:0005227	calcium-activated cation channel activity	"Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]	OMA
NV2t023522001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t023522001.1	biological_process	GO:0045910	negative regulation of DNA recombination	"Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]	PANTHER
NV2t023522001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t023524001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023524001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t023524001.1	molecular_function	GO:0005261	monoatomic cation channel activity	"Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023526001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023526001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t023526001.1	molecular_function	GO:0005261	monoatomic cation channel activity	"Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023527001.1	biological_process	GO:0046491	L-methylmalonyl-CoA metabolic process	"The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals." [GOC:jsg, GOC:mah, ISBN:0198506732]	PANTHER
NV2t023528001.1	biological_process	GO:0090435	protein localization to nuclear envelope	"A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb]	PANTHER
NV2t023529001.1	biological_process	GO:0016567	protein ubiquitination	"The process in which one or more ubiquitin groups are added to a protein." [GOC:ai]	PANTHER
NV2t023529001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023530001.1	biological_process	GO:0072488	ammonium transmembrane transport	"The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah]	InterPro
NV2t023530001.1	biological_process	GO:0097272	ammonium homeostasis	"Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560]	PANTHER
NV2t023530001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023530001.1	molecular_function	GO:0008519	ammonium transmembrane transporter activity	"Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640]	OMA
NV2t023531001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t023531001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t023531001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023531001.1	cellular_component	GO:0033588	elongator holoenzyme complex	"A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209]	InterPro
NV2t023531001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t023531001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t023531001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t023531001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023531001.1	molecular_function	GO:0043621	obsolete protein self-association	"OBSOLETE. Binding to a domain within the same polypeptide." [GOC:jl]	OMA
NV2t023532001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023533001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023533001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t023533002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023533002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023533002.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	OMA
NV2t023533002.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t023533003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023533003.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t023534001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t023534001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t023535001.1	biological_process	GO:0006936	muscle contraction	"A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]	OMA
NV2t023535001.1	biological_process	GO:0007015	actin filament organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]	OMA
NV2t023535001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t023535001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t023535001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t023536001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t023536001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	InterPro
NV2t023536001.1	cellular_component	GO:0005665	RNA polymerase II, core complex	"RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]	PANTHER
NV2t023536001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023537001.1	cellular_component	GO:0033186	CAF-1 complex	"A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276]	PANTHER
NV2t023538002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023538003.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023540001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023540002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023541001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023543001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023543002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023544001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023544001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t023544001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023544001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023544002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023544002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023544003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023544003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023544004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023544004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023545001.1	cellular_component	GO:0099078	BORC complex	"A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167]	PANTHER
NV2t023545001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t023545002.1	cellular_component	GO:0099078	BORC complex	"A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167]	PANTHER
NV2t023545003.1	cellular_component	GO:0099078	BORC complex	"A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167]	PANTHER
NV2t023547001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t023547001.1	biological_process	GO:0045132	meiotic chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]	OMA
NV2t023547001.1	biological_process	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	"The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in mitosis." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]	OMA
NV2t023547001.1	biological_process	GO:0051383	kinetochore organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t023547001.1	biological_process	GO:0051383	kinetochore organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t023547001.1	cellular_component	GO:0031262	Ndc80 complex	"An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis." [GOC:vw, PMID:28502666, PMID:34810257]	InterPro
NV2t023547001.1	cellular_component	GO:0031262	Ndc80 complex	"An essential outer kinetochore complex involved in the attachment of microtubule ends to the chromosomes during mitosis." [GOC:vw, PMID:28502666, PMID:34810257]	OMA
NV2t023547001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t023552001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552001.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552002.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552003.1	biological_process	GO:0007409	axonogenesis	"De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]	OMA
NV2t023552003.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	OMA
NV2t023552003.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023552003.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023552003.1	molecular_function	GO:0000987	cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018]	OMA
NV2t023552003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552004.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552004.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552005.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552005.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552006.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552006.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552006.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552007.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552007.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552007.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552008.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552008.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552008.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552009.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552009.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552009.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552010.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552010.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552010.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552011.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552011.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552011.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023552012.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023552012.1	biological_process	GO:0048665	neuron fate specification	"The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]	PANTHER
NV2t023552012.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023557001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t023557001.1	biological_process	GO:0009063	amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t023557001.1	biological_process	GO:0022904	respiratory electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]	OMA
NV2t023557001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t023557001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t023557001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t023557001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t023557001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t023557001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t023559001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023559001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t023559001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t023559001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023559001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023559001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023559001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023560001.1	biological_process	GO:0032483	regulation of Rab protein signal transduction	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]	PANTHER
NV2t023560003.1	biological_process	GO:0032483	regulation of Rab protein signal transduction	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]	PANTHER
NV2t023560004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023560005.1	biological_process	GO:0032483	regulation of Rab protein signal transduction	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]	PANTHER
NV2t023562001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t023562001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t023562001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023562001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023562002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t023562002.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t023562002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023562003.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t023562003.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t023562003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023562004.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t023562004.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t023562004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023566001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t023566001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023566002.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t023566002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023567001.1	biological_process	GO:0005513	detection of calcium ion	"The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg]	OMA
NV2t023567001.1	biological_process	GO:0006816	calcium ion transport	"The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t023567001.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t023567001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t023567001.1	biological_process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t023567001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t023567001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t023567001.1	biological_process	GO:0010646	regulation of cell communication	"Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]	OMA
NV2t023567001.1	biological_process	GO:0023051	regulation of signaling	"Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]	OMA
NV2t023567001.1	biological_process	GO:0051924	regulation of calcium ion transport	"Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t023567001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t023567001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023567001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023567001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023567001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023567001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t023567001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t023572001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023572001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023572001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023573001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023573001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023573001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023573001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t023573001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023573001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t023573001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023574001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t023574001.1	molecular_function	GO:0106050	tRNA 2'-O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide." [PMID:17242307]	InterPro
NV2t023574001.1	molecular_function	GO:0106050	tRNA 2'-O-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide." [PMID:17242307]	OMA
NV2t023576001.1	biological_process	GO:0030206	chondroitin sulfate biosynthetic process	"The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]	OMA
NV2t023576001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t023576001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t023576001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	InterPro
NV2t023576001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t023576001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t023576001.1	molecular_function	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	"Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN]	PANTHER
NV2t023579001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t023579001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t023579001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t023579001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t023579001.1	biological_process	GO:0048863	stem cell differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]	OMA
NV2t023579001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023579001.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	OMA
NV2t023579001.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	PANTHER
NV2t023579002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t023579002.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	PANTHER
NV2t023579003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t023579003.1	molecular_function	GO:0030971	receptor tyrosine kinase binding	"Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah]	PANTHER
NV2t023580001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	PANTHER
NV2t023582001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t023582001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023582002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t023582002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023582002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023582002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023583001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t023583001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t023583001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t023583001.1	biological_process	GO:0008334	histone mRNA metabolic process	"The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:krc, GOC:mah, PMID:17855393]	OMA
NV2t023583001.1	biological_process	GO:0033044	regulation of chromosome organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]	OMA
NV2t023583001.1	biological_process	GO:0033260	nuclear DNA replication	"The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t023583001.1	biological_process	GO:0043244	regulation of protein-containing complex disassembly	"Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]	OMA
NV2t023583001.1	biological_process	GO:0044770	cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle]	OMA
NV2t023583001.1	biological_process	GO:0051052	regulation of DNA metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	OMA
NV2t023583001.1	biological_process	GO:0061158	3'-UTR-mediated mRNA destabilization	"An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:dph, GOC:jh]	OMA
NV2t023583001.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	OMA
NV2t023583001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t023583001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t023583001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t023583001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023583001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023583001.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	OMA
NV2t023583001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t023583001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t023583001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t023583001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023583001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t023583001.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t023583001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t023583001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023583001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023583001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023583001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023583001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t023583001.1	molecular_function	GO:0042162	telomeric DNA binding	"Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]	OMA
NV2t023583001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t023583002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023583002.1	molecular_function	GO:0004386	helicase activity	"Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl]	InterPro
NV2t023583002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023583002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023584001.1	biological_process	GO:0006790	sulfur compound metabolic process	"The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]	PANTHER
NV2t023585001.1	biological_process	GO:0032483	regulation of Rab protein signal transduction	"Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]	PANTHER
NV2t023585001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023586001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t023586001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023586001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023586001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t023586001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	PANTHER
NV2t023590001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t023590001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t023590001.1	cellular_component	GO:0005672	transcription factor TFIIA complex	"A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669]	OMA
NV2t023591001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023593001.1	biological_process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	"The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos]	PANTHER
NV2t023593001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023593001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023594001.1	biological_process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	"The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732]	OMA
NV2t023594001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023594001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023594001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023594002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023596001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023596001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t023596001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	PANTHER
NV2t023596001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t023596001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023596001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023596001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t023601002.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t023601002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023601002.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t023601002.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t023603001.1	molecular_function	GO:0047150	betaine-homocysteine S-methyltransferase activity	"Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22336]	PANTHER
NV2t023604002.1	biological_process	GO:0048013	ephrin receptor signaling pathway	"The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb]	PANTHER
NV2t023604002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023605001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023605001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t023605001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023605001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023605001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t023605001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t023605001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023605001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023606001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t023606001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t023606001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t023606001.1	biological_process	GO:0016197	endosomal transport	"The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732]	OMA
NV2t023606001.1	biological_process	GO:1990126	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	PANTHER
NV2t023606001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t023606001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023606001.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	InterPro
NV2t023606001.1	molecular_function	GO:0032266	phosphatidylinositol-3-phosphate binding	"Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]	OMA
NV2t023606001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t023607001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	PANTHER
NV2t023607001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t023607001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t023607002.1	biological_process	GO:0044237	cellular metabolic process	"The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]	OMA
NV2t023607002.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t023607002.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	OMA
NV2t023607002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t023607002.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	OMA
NV2t023607002.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	PANTHER
NV2t023607002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t023607002.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t023608001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	PANTHER
NV2t023609001.1	cellular_component	GO:0008180	COP9 signalosome	"A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]	PANTHER
NV2t023609001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023610001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t023610001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023610001.1	molecular_function	GO:0016790	thiolester hydrolase activity	"Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-]	OMA
NV2t023610001.1	molecular_function	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]	OMA
NV2t023613001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023613001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023613001.1	biological_process	GO:0016485	protein processing	"Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]	PANTHER
NV2t023613001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t023613001.1	molecular_function	GO:0008236	serine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t023615001.1	biological_process	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	OMA
NV2t023615001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t023615001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t023615001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	PANTHER
NV2t023617001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023617001.1	molecular_function	GO:0050072	obsolete m7G(5')pppN diphosphatase activity	"OBSOLETE. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [GOC:curators]	PANTHER
NV2t023617001.1	molecular_function	GO:0140933	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	"Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+." [PMID:18820299, PMID:29483298]	InterPro
NV2t023617002.1	molecular_function	GO:0050072	obsolete m7G(5')pppN diphosphatase activity	"OBSOLETE. Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [GOC:curators]	PANTHER
NV2t023618001.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	PANTHER
NV2t023618002.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t023618002.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t023618002.1	molecular_function	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	"Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl]	OMA
NV2t023618002.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	InterPro
NV2t023618002.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	PANTHER
NV2t023618003.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	InterPro
NV2t023618003.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	PANTHER
NV2t023618004.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	InterPro
NV2t023618004.1	molecular_function	GO:0051377	mannose-ethanolamine phosphotransferase activity	"Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]	PANTHER
NV2t023619001.1	biological_process	GO:0001952	regulation of cell-matrix adhesion	"Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]	OMA
NV2t023619001.1	biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]	OMA
NV2t023619001.1	biological_process	GO:0007162	negative regulation of cell adhesion	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]	OMA
NV2t023619001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t023619001.1	biological_process	GO:0010506	regulation of autophagy	"Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]	OMA
NV2t023619001.1	biological_process	GO:0010942	obsolete positive regulation of cell death	"OBSOLETE. Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]	OMA
NV2t023619001.1	biological_process	GO:0030148	sphingolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t023619001.1	biological_process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	"A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]	OMA
NV2t023619001.1	biological_process	GO:0033628	regulation of cell adhesion mediated by integrin	"Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]	OMA
NV2t023619001.1	biological_process	GO:0033993	response to lipid	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]	OMA
NV2t023619001.1	biological_process	GO:0034312	diol biosynthetic process	"The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah]	OMA
NV2t023619001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t023619001.1	biological_process	GO:0044271	obsolete cellular nitrogen compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]	OMA
NV2t023619001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t023619001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	PANTHER
NV2t023619001.1	biological_process	GO:0060049	regulation of protein glycosylation	"Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr]	OMA
NV2t023619001.1	biological_process	GO:1901700	response to oxygen-containing compound	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t023619001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t023619001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t023619001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	InterPro
NV2t023619001.1	molecular_function	GO:0017040	N-acylsphingosine amidohydrolase activity	"Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]	OMA
NV2t023620001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023620001.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	PANTHER
NV2t023622002.1	biological_process	GO:2001046	positive regulation of integrin-mediated signaling pathway	"Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol]	PANTHER
NV2t023622002.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	InterPro
NV2t023623001.1	biological_process	GO:0017196	N-terminal peptidyl-methionine acetylation	"The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]	OMA
NV2t023623001.1	cellular_component	GO:0031414	N-terminal protein acetyltransferase complex	"A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah]	OMA
NV2t023623001.1	cellular_component	GO:0031417	NatC complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471]	InterPro
NV2t023623001.1	cellular_component	GO:0031417	NatC complex	"A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471]	PANTHER
NV2t023624001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t023624001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023624001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t023624002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t023625001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t023625001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t023625001.1	biological_process	GO:0051261	protein depolymerization	"The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]	OMA
NV2t023625001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t023625001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023625001.1	cellular_component	GO:0098793	presynapse	"The part of a synapse that is part of the presynaptic cell." [GOC:dos]	OMA
NV2t023625001.1	cellular_component	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	OMA
NV2t023625001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023625001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t023630001.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	InterPro
NV2t023630001.1	biological_process	GO:0022900	electron transport chain	"A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport]	OMA
NV2t023630001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t023630001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t023631001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023631001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023631001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023631001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023635001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t023635001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023638001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t023638001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023638001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023638001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t023640001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023643001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023644001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023644001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023644001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t023644001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023646001.1	biological_process	GO:0050658	RNA transport	"The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t023646001.1	biological_process	GO:0051170	import into nucleus	"The directed movement of substances into the nucleus." [GOC:ai]	OMA
NV2t023646001.1	biological_process	GO:0061015	snRNA import into nucleus	"The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t023646001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023646001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023648001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023650001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t023650001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023652001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023652001.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t023652002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023652002.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t023652003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023652003.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t023652004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023652004.1	biological_process	GO:1904257	zinc ion import into Golgi lumen	"The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi lumen." [GO_REF:0000075, GOC:TermGenie, PMID:25732056]	PANTHER
NV2t023654001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023654001.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	PANTHER
NV2t023654001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023654001.1	molecular_function	GO:0005216	monoatomic ion channel activity	"Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023655001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	PANTHER
NV2t023660001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023660001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t023660001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023662001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	PANTHER
NV2t023662001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023662001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t023662001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t023662001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t023664001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t023664001.1	biological_process	GO:0031167	rRNA methylation	"The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]	InterPro
NV2t023664001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023664001.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	InterPro
NV2t023664001.1	molecular_function	GO:0008173	RNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]	OMA
NV2t023667001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023667001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023667001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023667001.1	molecular_function	GO:0004984	olfactory receptor activity	"Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]	OMA
NV2t023668001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t023668001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t023668001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t023668001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023668001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t023668001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t023668001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t023668001.1	molecular_function	GO:0016018	cyclosporin A binding	"Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb]	OMA
NV2t023669001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t023669001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t023669001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t023669001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t023669001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t023670001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t023670001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t023670001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t023670001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t023670001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t023672001.1	biological_process	GO:1901006	ubiquinone-6 biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone-6." [GOC:TermGenie]	PANTHER
NV2t023672001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t023672001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t023672001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t023673001.1	biological_process	GO:0070197	meiotic attachment of telomere to nuclear envelope	"The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation." [GOC:jp, GOC:pr, GOC:vw, PMID:18818742]	InterPro
NV2t023673001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t023673001.1	molecular_function	GO:0060590	ATPase regulator activity	"Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]	OMA
NV2t023674001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023676001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023676001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023676001.1	molecular_function	GO:0043531	ADP binding	"Binding to ADP, adenosine 5'-diphosphate." [GOC:jl]	InterPro
NV2t023678001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023678001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t023680001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023680001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t023680001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023680001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023680002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023680002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023680002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023681001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t023681001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023681001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t023681001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t023681001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023681001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023681001.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	PANTHER
NV2t023681001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t023681001.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	InterPro
NV2t023681001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t023681001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023681001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023683001.1	biological_process	GO:0009966	regulation of signal transduction	"Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t023683001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t023683001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023683001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t023684001.1	biological_process	GO:0008643	carbohydrate transport	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]	OMA
NV2t023684001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t023684001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t023685001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t023685001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t023685001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t023685001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t023685001.1	cellular_component	GO:0016581	NuRD complex	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]	OMA
NV2t023685001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t023685001.1	molecular_function	GO:0008327	methyl-CpG binding	"Binding to a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232]	OMA
NV2t023685001.1	molecular_function	GO:0008327	methyl-CpG binding	"Binding to a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232]	PANTHER
NV2t023687001.1	biological_process	GO:0002181	cytoplasmic translation	"The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]	OMA
NV2t023687001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023687001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t023687001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t023687001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t023688001.1	biological_process	GO:0008643	carbohydrate transport	"The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]	OMA
NV2t023688001.1	biological_process	GO:0043474	pigment metabolic process involved in pigmentation	"The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:dph, GOC:jl, GOC:tb]	OMA
NV2t023688001.1	biological_process	GO:0048021	regulation of melanin biosynthetic process	"Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid]	OMA
NV2t023688001.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t023688001.1	biological_process	GO:0072348	sulfur compound transport	"The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t023688001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t023688001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t023688001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023688001.1	cellular_component	GO:0048770	pigment granule	"A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]	OMA
NV2t023688001.1	molecular_function	GO:0015175	neutral L-amino acid transmembrane transporter activity	"Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023688001.1	molecular_function	GO:0015293	symporter activity	"Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]	OMA
NV2t023688001.1	molecular_function	GO:1901682	sulfur compound transmembrane transporter activity	"Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t023688002.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t023688003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023688003.1	biological_process	GO:0071702	organic substance transport	"The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah]	PANTHER
NV2t023689001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023689001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t023689001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t023690001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t023690002.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t023690003.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t023690003.1	biological_process	GO:0070848	response to growth factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah]	OMA
NV2t023690003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t023690003.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t023690003.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t023691001.1	biological_process	GO:0006000	fructose metabolic process	"The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732]	InterPro
NV2t023691001.1	biological_process	GO:0006003	fructose 2,6-bisphosphate metabolic process	"The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732]	InterPro
NV2t023691001.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t023691001.1	biological_process	GO:0019637	organophosphate metabolic process	"The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732]	OMA
NV2t023691001.1	biological_process	GO:1901135	carbohydrate derivative metabolic process	"The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie]	OMA
NV2t023691001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023691001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023691001.1	molecular_function	GO:0008443	phosphofructokinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule." [GOC:jl]	OMA
NV2t023691001.1	molecular_function	GO:0019203	carbohydrate phosphatase activity	"Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah]	OMA
NV2t023691002.1	biological_process	GO:0006000	fructose metabolic process	"The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732]	InterPro
NV2t023691002.1	biological_process	GO:0006003	fructose 2,6-bisphosphate metabolic process	"The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732]	InterPro
NV2t023691003.1	biological_process	GO:0006000	fructose metabolic process	"The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732]	InterPro
NV2t023691003.1	biological_process	GO:0006003	fructose 2,6-bisphosphate metabolic process	"The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732]	InterPro
NV2t023691004.1	biological_process	GO:0006000	fructose metabolic process	"The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732]	InterPro
NV2t023691004.1	biological_process	GO:0006003	fructose 2,6-bisphosphate metabolic process	"The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732]	InterPro
NV2t023692001.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t023692002.1	biological_process	GO:0009097	isoleucine biosynthetic process	"The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]	PANTHER
NV2t023694001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t023694001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023694001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023694001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t023694001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023694001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t023694001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t023694002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t023694002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023694002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023694002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023694002.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t023694003.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t023694003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023694003.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023694003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023694003.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t023694004.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t023694004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023694004.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023694004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023694004.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t023694005.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t023694005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023694005.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023694005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023694005.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t023697001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023697001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023698001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023698001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023699001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023699001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t023699001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023699001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023699002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023699002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023700001.1	biological_process	GO:0006518	peptide metabolic process	"The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators]	OMA
NV2t023700001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t023700001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t023700001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023700001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023700001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023700001.1	molecular_function	GO:0004504	peptidylglycine monooxygenase activity	"Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3]	OMA
NV2t023700001.1	molecular_function	GO:0005507	copper ion binding	"Binding to a copper (Cu) ion." [GOC:ai]	OMA
NV2t023700001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t023700002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t023700002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023700002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t023700002.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t023704001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023704001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t023704001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023706002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023706002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023706004.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023706004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023706006.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023706006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023707001.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t023707001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023707001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t023708001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t023708001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t023708002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t023709001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t023709001.1	molecular_function	GO:0046316	gluconokinase activity	"Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+." [EC:2.7.1.12, RHEA:19433]	PANTHER
NV2t023709002.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t023709002.1	molecular_function	GO:0046316	gluconokinase activity	"Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+." [EC:2.7.1.12, RHEA:19433]	PANTHER
NV2t023709003.1	biological_process	GO:0009313	oligosaccharide catabolic process	"The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t023709003.1	biological_process	GO:0044275	obsolete cellular carbohydrate catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]	OMA
NV2t023709003.1	biological_process	GO:0072329	monocarboxylic acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah]	OMA
NV2t023709003.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t023709003.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t023709003.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t023709003.1	molecular_function	GO:0046316	gluconokinase activity	"Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+." [EC:2.7.1.12, RHEA:19433]	PANTHER
NV2t023710001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t023710001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t023710001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023710001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t023711001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023711001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023711001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t023713001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t023713001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t023715001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023716001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023716001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023723001.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t023723002.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	InterPro
NV2t023723002.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t023723003.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	InterPro
NV2t023723003.1	biological_process	GO:0044772	mitotic cell cycle phase transition	"The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]	PANTHER
NV2t023725001.1	biological_process	GO:0001775	cell activation	"A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell." [GOC:mgi_curators]	OMA
NV2t023725001.1	biological_process	GO:0002376	immune system process	"Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add]	OMA
NV2t023725001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t023725001.1	biological_process	GO:0051452	intracellular pH reduction	"Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]	OMA
NV2t023725001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023725001.1	cellular_component	GO:0030660	Golgi-associated vesicle membrane	"The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]	OMA
NV2t023725001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t023725001.1	molecular_function	GO:0008308	voltage-gated monoatomic anion channel activity	"Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729]	OMA
NV2t023726001.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t023726001.1	cellular_component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	"Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]	OMA
NV2t023726001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t023726001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	InterPro
NV2t023726001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t023726001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t023726001.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t023726001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	OMA
NV2t023726001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	PANTHER
NV2t023727001.1	biological_process	GO:0006887	exocytosis	"A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285]	OMA
NV2t023727001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	OMA
NV2t023727001.1	biological_process	GO:0006893	Golgi to plasma membrane transport	"The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]	PANTHER
NV2t023727001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t023727001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t023727001.1	cellular_component	GO:0000145	exocyst	"A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152]	OMA
NV2t023727001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t023728001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023728001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t023728001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023728001.1	molecular_function	GO:0015252	proton channel activity	"Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023728001.1	molecular_function	GO:0022843	voltage-gated monoatomic cation channel activity	"Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023730001.1	biological_process	GO:0070920	regulation of regulatory ncRNA processing	"Any process that modulates the frequency, rate or extent of regulatory non-coding RNA processing." [GOC:mah]	PANTHER
NV2t023732001.1	molecular_function	GO:0035591	signaling adaptor activity	"The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498]	PANTHER
NV2t023733001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023733001.1	molecular_function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	"Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]	PANTHER
NV2t023739001.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	InterPro
NV2t023739001.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	OMA
NV2t023739001.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	PANTHER
NV2t023739001.1	molecular_function	GO:0008318	protein prenyltransferase activity	"Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]	OMA
NV2t023739002.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	InterPro
NV2t023739002.1	biological_process	GO:0018342	protein prenylation	"The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]	PANTHER
NV2t023741001.1	biological_process	GO:0006857	oligopeptide transport	"The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732]	OMA
NV2t023741001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023741001.1	biological_process	GO:0140206	dipeptide import across plasma membrane	"The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]	PANTHER
NV2t023741001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023741001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023741002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023741002.1	biological_process	GO:0140206	dipeptide import across plasma membrane	"The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]	PANTHER
NV2t023741003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023741003.1	biological_process	GO:0140206	dipeptide import across plasma membrane	"The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]	PANTHER
NV2t023741004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023741004.1	biological_process	GO:0140206	dipeptide import across plasma membrane	"The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946]	PANTHER
NV2t023742001.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t023742001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t023742001.1	biological_process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t023742001.1	biological_process	GO:0042795	snRNA transcription by RNA polymerase II	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]	OMA
NV2t023742001.1	biological_process	GO:0042795	snRNA transcription by RNA polymerase II	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t023742001.1	biological_process	GO:0042796	snRNA transcription by RNA polymerase III	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]	OMA
NV2t023742001.1	biological_process	GO:0045945	positive regulation of transcription by RNA polymerase III	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH]	OMA
NV2t023742001.1	cellular_component	GO:0000791	euchromatin	"A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156]	OMA
NV2t023742001.1	cellular_component	GO:0008023	transcription elongation factor complex	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]	InterPro
NV2t023742001.1	cellular_component	GO:0008023	transcription elongation factor complex	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]	OMA
NV2t023742001.1	cellular_component	GO:0015030	Cajal body	"A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785]	OMA
NV2t023742001.1	cellular_component	GO:0016607	nuclear speck	"A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]	OMA
NV2t023742001.1	cellular_component	GO:0035363	histone locus body	"A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235]	OMA
NV2t023742001.1	molecular_function	GO:0000987	cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers." [GOC:txnOH-2018]	OMA
NV2t023742001.1	molecular_function	GO:0019902	phosphatase binding	"Binding to a phosphatase." [GOC:jl]	OMA
NV2t023742002.1	biological_process	GO:0042795	snRNA transcription by RNA polymerase II	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t023742002.1	cellular_component	GO:0008023	transcription elongation factor complex	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]	InterPro
NV2t023742003.1	biological_process	GO:0042795	snRNA transcription by RNA polymerase II	"The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]	PANTHER
NV2t023742003.1	cellular_component	GO:0008023	transcription elongation factor complex	"Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]	InterPro
NV2t023743001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023743001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t023743001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t023743002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023743002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t023745001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t023745001.1	biological_process	GO:0006754	ATP biosynthetic process	"The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732]	PANTHER
NV2t023745001.1	biological_process	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t023745001.1	molecular_function	GO:0008796	bis(5'-nucleosyl)-tetraphosphatase activity	"Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai]	InterPro
NV2t023745001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t023745001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023747001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t023747001.1	biological_process	GO:0007019	microtubule depolymerization	"The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]	PANTHER
NV2t023747001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023747001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t023748001.1	biological_process	GO:0051028	mRNA transport	"The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	InterPro
NV2t023748001.1	biological_process	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	"The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism." [GOC:mah]	PANTHER
NV2t023748001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t023748001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023748001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023748001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023750001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t023750001.1	biological_process	GO:0006513	protein monoubiquitination	"Addition of a single ubiquitin group to a protein." [GOC:ai]	OMA
NV2t023750001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t023750001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	OMA
NV2t023750001.1	molecular_function	GO:0061631	ubiquitin conjugating enzyme activity	"Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph]	PANTHER
NV2t023751001.1	biological_process	GO:0006012	galactose metabolic process	"The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732]	OMA
NV2t023751001.1	biological_process	GO:0006793	phosphorus metabolic process	"The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus." [GOC:ai]	OMA
NV2t023751001.1	biological_process	GO:0009225	nucleotide-sugar metabolic process	"The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]	OMA
NV2t023751001.1	biological_process	GO:0016052	carbohydrate catabolic process	"The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732]	OMA
NV2t023751001.1	biological_process	GO:0033499	galactose catabolic process via UDP-galactose	"The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821]	InterPro
NV2t023751001.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t023751001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023751001.1	molecular_function	GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	"Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13989]	InterPro
NV2t023751001.1	molecular_function	GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	"Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13989]	OMA
NV2t023751001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023752001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	PANTHER
NV2t023757001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t023757001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t023760001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t023760001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t023760001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023760001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023760002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t023760002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023763001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t023763001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t023763001.1	biological_process	GO:0006435	threonyl-tRNA aminoacylation	"The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t023763001.1	biological_process	GO:0006435	threonyl-tRNA aminoacylation	"The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t023763001.1	biological_process	GO:0043039	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	InterPro
NV2t023763001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023763001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t023763001.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t023763001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023765001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023776001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023777001.1	biological_process	GO:0035308	negative regulation of protein dephosphorylation	"Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	PANTHER
NV2t023777002.1	biological_process	GO:0035308	negative regulation of protein dephosphorylation	"Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	PANTHER
NV2t023778001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023778001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	PANTHER
NV2t023780001.1	biological_process	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	OMA
NV2t023780001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t023780001.1	biological_process	GO:0030148	sphingolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t023780001.1	biological_process	GO:0030497	fatty acid elongation	"The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]	OMA
NV2t023780001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	OMA
NV2t023780001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t023780001.1	biological_process	GO:0045069	regulation of viral genome replication	"Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai]	OMA
NV2t023780001.1	biological_process	GO:0048524	positive regulation of viral process	"Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl]	OMA
NV2t023780001.1	biological_process	GO:0065008	regulation of biological quality	"Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t023780001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t023780001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t023780001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t023781001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023781001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023782001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t023782001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t023782001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t023782001.1	cellular_component	GO:0009368	endopeptidase Clp complex	"A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464]	OMA
NV2t023782001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023782001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023782001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023782001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t023782001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t023782001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t023782001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t023782001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t023782002.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t023782002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023782002.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t023785001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023785001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023785001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023788001.1	biological_process	GO:0000301	retrograde transport, vesicle recycling within Golgi	"The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363]	OMA
NV2t023788001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t023788001.1	biological_process	GO:0070085	glycosylation	"The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah]	OMA
NV2t023788001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t023788001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	OMA
NV2t023789001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023790001.1	biological_process	GO:0006478	peptidyl-tyrosine sulfation	"The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172]	OMA
NV2t023790001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t023790001.1	molecular_function	GO:0008476	protein-tyrosine sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]	InterPro
NV2t023790001.1	molecular_function	GO:0008476	protein-tyrosine sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]	OMA
NV2t023793001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023793001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023793001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023794001.1	biological_process	GO:0009060	aerobic respiration	"The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590]	OMA
NV2t023794001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t023794001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	OMA
NV2t023794001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t023794001.1	cellular_component	GO:0045272	plasma membrane respiratory chain complex I	"A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t023794001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t023794001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t023794001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t023794001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	InterPro
NV2t023794001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t023794001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t023795001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t023796001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t023796001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023797001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t023797001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023797001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023797001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023797002.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t023797002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023797002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023798001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t023798001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023798001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023798002.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t023798002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023798002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023798003.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t023798003.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023798003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023798004.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t023798004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023798004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t023798004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t023799001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023800001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	InterPro
NV2t023800001.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t023800002.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	InterPro
NV2t023800002.1	biological_process	GO:0048478	obsolete replication fork protection	"OBSOLETE. Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]	PANTHER
NV2t023802001.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t023802001.1	molecular_function	GO:0003968	RNA-dependent RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]	InterPro
NV2t023802002.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t023802002.1	molecular_function	GO:0003968	RNA-dependent RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]	InterPro
NV2t023802003.1	cellular_component	GO:0031380	nuclear RNA-directed RNA polymerase complex	"A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]	PANTHER
NV2t023802003.1	molecular_function	GO:0003968	RNA-dependent RNA polymerase activity	"Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf]	InterPro
NV2t023803005.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t023803005.1	molecular_function	GO:0035529	NADH pyrophosphatase activity	"Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [PMID:12399474, PMID:20181750, RHEA:48868]	PANTHER
NV2t023804001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t023804001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t023804001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	InterPro
NV2t023804001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t023806001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023806001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023807001.1	biological_process	GO:0000266	mitochondrial fission	"The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]	OMA
NV2t023807001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t023807001.1	biological_process	GO:0042407	cristae formation	"The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]	OMA
NV2t023807001.1	biological_process	GO:0055091	phospholipid homeostasis	"Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t023807001.1	biological_process	GO:0061564	axon development	"The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr]	OMA
NV2t023807001.1	biological_process	GO:0090148	membrane fission	"A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t023807001.1	biological_process	GO:0090149	mitochondrial membrane fission	"A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t023807001.1	cellular_component	GO:0005741	mitochondrial outer membrane	"The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]	OMA
NV2t023807001.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t023808001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023808002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023808003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023808004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023808005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023809001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t023810001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t023810001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	OMA
NV2t023812001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t023812001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	InterPro
NV2t023812001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t023812001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t023812001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	OMA
NV2t023815001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t023815001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t023815001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023815001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023815001.1	molecular_function	GO:0016500	protein-hormone receptor activity	"Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]	InterPro
NV2t023818001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023825001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023825001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023825001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t023825001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t023825001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t023825001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023828001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t023828001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023828001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023828001.1	molecular_function	GO:0008417	fucosyltransferase activity	"Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]	OMA
NV2t023828001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t023829001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t023829001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t023829001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t023830001.1	biological_process	GO:0019367	fatty acid elongation, saturated fatty acid	"Elongation of a saturated fatty acid chain." [GOC:mah]	OMA
NV2t023830001.1	biological_process	GO:0019368	fatty acid elongation, unsaturated fatty acid	"Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah]	OMA
NV2t023830001.1	biological_process	GO:0030148	sphingolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]	OMA
NV2t023830001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	OMA
NV2t023830001.1	biological_process	GO:0042761	very long-chain fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t023830001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t023830001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023830001.1	molecular_function	GO:0009922	fatty acid elongase activity	"Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit." [PMID:16564093, PMID:19763486, RHEA:32727]	OMA
NV2t023832001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023832001.1	molecular_function	GO:0050840	extracellular matrix binding	"Binding to a component of the extracellular matrix." [GOC:ai]	PANTHER
NV2t023833001.1	biological_process	GO:0099525	presynaptic dense core vesicle exocytosis	"The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208]	PANTHER
NV2t023833001.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t023833002.1	biological_process	GO:0007528	neuromuscular junction development	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013]	OMA
NV2t023833002.1	biological_process	GO:0016081	synaptic vesicle docking	"The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process." [PMID:15217342]	OMA
NV2t023833002.1	biological_process	GO:0016082	synaptic vesicle priming	"A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane." [GOC:mah, PMID:15217342, PMID:23060190]	OMA
NV2t023833002.1	biological_process	GO:0016188	synaptic vesicle maturation	"Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709]	OMA
NV2t023833002.1	biological_process	GO:0035249	synaptic transmission, glutamatergic	"The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos]	OMA
NV2t023833002.1	biological_process	GO:0099525	presynaptic dense core vesicle exocytosis	"The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208]	OMA
NV2t023833002.1	biological_process	GO:0099525	presynaptic dense core vesicle exocytosis	"The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208]	PANTHER
NV2t023833002.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t023833002.1	cellular_component	GO:0031594	neuromuscular junction	"The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln]	OMA
NV2t023833002.1	cellular_component	GO:0042734	presynaptic membrane	"A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]	OMA
NV2t023833002.1	cellular_component	GO:0043195	terminal bouton	"Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]	OMA
NV2t023833002.1	cellular_component	GO:0098831	presynaptic active zone cytoplasmic component	"A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles." [GOC:dos]	OMA
NV2t023833002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023833002.1	molecular_function	GO:0005516	calmodulin binding	"Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]	OMA
NV2t023833002.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	InterPro
NV2t023833002.1	molecular_function	GO:0005543	phospholipid binding	"Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t023833002.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t023834001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t023836001.1	biological_process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t023836001.1	biological_process	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]	OMA
NV2t023836001.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	OMA
NV2t023836001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	OMA
NV2t023836001.1	biological_process	GO:0070936	protein K48-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]	OMA
NV2t023836001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t023836001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t023836001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t023836001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t023838001.1	biological_process	GO:0009247	glycolipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators]	OMA
NV2t023838001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023838001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t023839001.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t023839001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023839001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t023839001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023839001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023839001.1	molecular_function	GO:0008273	calcium, potassium:sodium antiporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1]	OMA
NV2t023842001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	InterPro
NV2t023842001.1	biological_process	GO:0006102	isocitrate metabolic process	"The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732]	PANTHER
NV2t023842001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t023842001.1	molecular_function	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]	OMA
NV2t023842001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t023842001.1	molecular_function	GO:0051287	NAD binding	"Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]	InterPro
NV2t023845001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t023845001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023845001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t023846001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t023846001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t023846001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	OMA
NV2t023849001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t023850001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023850001.1	biological_process	GO:0098655	monoatomic cation transmembrane transport	"The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom." [GOC:dos, GOC:vw]	OMA
NV2t023850001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t023850001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t023850001.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t023850001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023851001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023851001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023851001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023851001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t023851001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023851001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t023851001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023852001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023852001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023852001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023852001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t023852001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023852001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023852001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t023852001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t023852001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023854001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023854001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023854001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023854001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t023854001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023854001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t023854001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023855001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t023855002.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	InterPro
NV2t023856001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t023856001.1	biological_process	GO:0043048	dolichyl monophosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl]	PANTHER
NV2t023856001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t023856001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	OMA
NV2t023856001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t023859001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023859001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023859001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t023859001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t023859001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t023859001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023859001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023861001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023861001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	PANTHER
NV2t023863001.1	biological_process	GO:0061709	reticulophagy	"The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717]	PANTHER
NV2t023864001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t023864001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t023865001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	OMA
NV2t023865001.1	molecular_function	GO:0008253	5'-nucleotidase activity	"Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]	PANTHER
NV2t023866001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t023866002.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t023866003.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t023883001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	PANTHER
NV2t023883001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023884001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t023884001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t023884001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023884002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t023884002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t023884002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023885001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023886001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t023886001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	OMA
NV2t023886001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t023886001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t023886001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023886001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t023886002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t023886002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t023886002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023886003.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t023886003.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t023886003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t023888001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t023888001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t023890001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t023890001.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t023890002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t023890002.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t023890003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023890003.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	InterPro
NV2t023890003.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	OMA
NV2t023890003.1	molecular_function	GO:0140658	ATP-dependent chromatin remodeler activity	"An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]	PANTHER
NV2t023891001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023891001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023891001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023891001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023893001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023893001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t023893001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t023893002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023893002.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t023893003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023893003.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t023902001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t023903001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t023904001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	PANTHER
NV2t023904001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023905001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t023905002.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t023907001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t023907002.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t023908001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t023908001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	PANTHER
NV2t023909001.1	biological_process	GO:0001818	negative regulation of cytokine production	"Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t023909001.1	biological_process	GO:0001933	negative regulation of protein phosphorylation	"Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t023909001.1	biological_process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	"Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]	OMA
NV2t023909001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t023909001.1	biological_process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]	OMA
NV2t023909001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t023909001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	OMA
NV2t023909001.1	biological_process	GO:0045292	mRNA cis splicing, via spliceosome	"The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335]	PANTHER
NV2t023909001.1	biological_process	GO:0045824	negative regulation of innate immune response	"Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]	OMA
NV2t023909001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t023909001.1	biological_process	GO:0062207	regulation of pattern recognition receptor signaling pathway	"Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]	OMA
NV2t023909001.1	biological_process	GO:0071222	cellular response to lipopolysaccharide	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]	OMA
NV2t023909001.1	biological_process	GO:0071356	cellular response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	OMA
NV2t023909001.1	biological_process	GO:1902532	negative regulation of intracellular signal transduction	"Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t023909001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023909001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t023909001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t023909001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t023909001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t023909001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023910001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t023910001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t023910001.1	cellular_component	GO:0005763	mitochondrial small ribosomal subunit	"The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]	PANTHER
NV2t023910001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t023910001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t023910001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t023910001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t023912001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023912001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023912001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023912001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t023912001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023912001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t023912001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023913001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t023913001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023913001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023913001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t023913001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t023913001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t023913001.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t023913001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t023913001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t023914001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t023914001.1	biological_process	GO:0007031	peroxisome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]	OMA
NV2t023914001.1	biological_process	GO:0015718	monocarboxylic acid transport	"The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]	OMA
NV2t023914001.1	biological_process	GO:0015919	peroxisomal membrane transport	"The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai]	OMA
NV2t023914001.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	OMA
NV2t023914001.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t023914001.1	biological_process	GO:1905039	carboxylic acid transmembrane transport	"The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563]	OMA
NV2t023914001.1	cellular_component	GO:0005778	peroxisomal membrane	"The lipid bilayer surrounding a peroxisome." [GOC:mah]	OMA
NV2t023914001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023914001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t023914001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023914001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023914001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t023914001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t023915001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023915001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t023917001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t023917001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t023917001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023917001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023918001.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t023918001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023918001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t023918002.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t023918002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023918002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t023919001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023919001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t023919001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t023919001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t023919001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t023919001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t023919002.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t023919002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t023920001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	OMA
NV2t023920001.1	cellular_component	GO:0072546	EMC complex	"A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176]	PANTHER
NV2t023920001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t023920001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023923001.1	molecular_function	GO:0004035	alkaline phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]	OMA
NV2t023923001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t023923002.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	InterPro
NV2t023925001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t023925001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t023925001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t023925001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t023925001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t023925001.1	cellular_component	GO:0005768	endosome	"A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]	OMA
NV2t023925001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t023926001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t023926001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023929001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023931001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t023931001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023931001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023933001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	PANTHER
NV2t023933001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023936001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023936001.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t023936001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023936001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t023936002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023936002.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t023936002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023936003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023936003.1	cellular_component	GO:0034751	aryl hydrocarbon receptor complex	"A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]	PANTHER
NV2t023938001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t023938001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023938001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t023938001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023938002.1	biological_process	GO:0000278	mitotic cell cycle	"Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]	OMA
NV2t023938002.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t023938002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t023938002.1	biological_process	GO:0016578	obsolete histone deubiquitination	"OBSOLETE. The modification of histones by removal of ubiquitin groups." [GOC:ai]	OMA
NV2t023938002.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t023938002.1	biological_process	GO:0031647	regulation of protein stability	"Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t023938002.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t023938002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023938002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023938002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t023938002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t023938002.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t023938002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t023938002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t023938002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t023939001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t023939001.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	OMA
NV2t023939001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023939001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t023939001.1	molecular_function	GO:0004525	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	OMA
NV2t023941001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023941001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t023941001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t023941002.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023941002.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t023941003.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023941003.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t023941004.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t023941004.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t023946001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023946001.1	molecular_function	GO:0008375	acetylglucosaminyltransferase activity	"Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732]	PANTHER
NV2t023946001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t023946001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t023947001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t023947001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023947001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023947001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t023947002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t023947002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023947002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023947002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023947002.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t023947002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023947002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t023949001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t023949001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023949001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023949001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t023949001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t023949001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t023949001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t023957001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023957001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023957001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023957002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023957002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023957002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023957003.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023957003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t023957003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023957003.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t023957003.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023957003.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t023957003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023957003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t023957004.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023957004.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023957004.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023957005.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023957005.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023957005.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023957006.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023957006.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023957006.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023957007.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t023957007.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t023957007.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t023959001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023959001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023959001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t023961001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023961001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023961001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t023962001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t023962001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t023965001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t023965001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t023965001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t023968001.1	biological_process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	"Any semaphorin-plexin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009]	PANTHER
NV2t023969001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t023969001.1	biological_process	GO:0006687	glycosphingolipid metabolic process	"The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]	OMA
NV2t023969001.1	biological_process	GO:0009311	oligosaccharide metabolic process	"The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732]	OMA
NV2t023969001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t023969001.1	biological_process	GO:0046514	ceramide catabolic process	"The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]	OMA
NV2t023969001.1	biological_process	GO:1901658	glycosyl compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t023969001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023969001.1	molecular_function	GO:0015925	galactosidase activity	"Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai]	OMA
NV2t023970001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t023970001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t023970001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023970001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023973001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023973001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023973001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023973001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t023974001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023974001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023974001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023974001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t023975001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t023975001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023975001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t023975001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t023976001.1	biological_process	GO:0060147	regulation of post-transcriptional gene silencing	"Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]	InterPro
NV2t023976001.1	biological_process	GO:0060147	regulation of post-transcriptional gene silencing	"Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]	OMA
NV2t023976001.1	cellular_component	GO:0005925	focal adhesion	"A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]	OMA
NV2t023976002.1	biological_process	GO:0060147	regulation of post-transcriptional gene silencing	"Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]	InterPro
NV2t023979001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t023979001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t023979001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t023979001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t023981001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023990001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t023990001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t023990001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023990001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t023990001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t023990001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t023991001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	OMA
NV2t023991001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t023991001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t023991001.1	cellular_component	GO:0055087	Ski complex	"A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509, PMID:18042677]	PANTHER
NV2t023991001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t023992001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	OMA
NV2t023992001.1	biological_process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	"A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494]	PANTHER
NV2t023992001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t023992001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t023996001.1	biological_process	GO:0007097	nuclear migration	"The directed movement of the nucleus to a specific location within a cell." [GOC:ai]	OMA
NV2t023996001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t023996001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t023996001.1	biological_process	GO:0010825	positive regulation of centrosome duplication	"Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]	OMA
NV2t023996001.1	biological_process	GO:0045724	positive regulation of cilium assembly	"Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators]	OMA
NV2t023996001.1	biological_process	GO:0046601	positive regulation of centriole replication	"Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai]	OMA
NV2t023996001.1	biological_process	GO:0061351	neural precursor cell proliferation	"The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf]	OMA
NV2t023996001.1	biological_process	GO:1903722	regulation of centriole elongation	"Any process that modulates the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]	OMA
NV2t023996001.1	biological_process	GO:1903724	positive regulation of centriole elongation	"Any process that activates or increases the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062]	PANTHER
NV2t023996001.1	biological_process	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t023996001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t023996001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t023998001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024002001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t024005001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024005001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024005001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024005001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024006001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024006001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024008001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024008001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024008001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t024008001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t024009001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024009001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t024009002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024009002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t024009002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t024009002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t024009002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024010001.1	biological_process	GO:0008202	steroid metabolic process	"The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]	OMA
NV2t024010001.1	biological_process	GO:0032787	monocarboxylic acid metabolic process	"The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]	OMA
NV2t024010001.1	biological_process	GO:1901615	organic hydroxy compound metabolic process	"The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t024010001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t024010001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t024010001.1	molecular_function	GO:0016854	racemase and epimerase activity	"Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732]	OMA
NV2t024011001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024011001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	OMA
NV2t024011001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024011001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024013001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024013001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024013001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024013001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t024015001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t024015001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024015001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024015001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t024016001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t024016001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024016001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024016001.1	molecular_function	GO:0005272	sodium channel activity	"Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t024017001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t024017001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024017001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024017001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t024018001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024018001.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	PANTHER
NV2t024019001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024019001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t024019001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024019001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024019001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t024020001.1	cellular_component	GO:0034457	Mpp10 complex	"A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p." [GOC:mah, PMID:17515605]	InterPro
NV2t024021001.1	cellular_component	GO:0043197	dendritic spine	"A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]	PANTHER
NV2t024021001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024023001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t024024001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t024024001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t024024001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024024001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024024001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024024001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024025001.1	cellular_component	GO:0071782	endoplasmic reticulum tubular network	"A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336]	PANTHER
NV2t024025001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t024025001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t024027001.1	biological_process	GO:0030097	hemopoiesis	"The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]	OMA
NV2t024027001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024028001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t024028002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t024029001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t024031001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	OMA
NV2t024031001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t024031001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024031001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024031002.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t024031003.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t024032001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t024032002.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t024033001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t024033001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t024033001.1	biological_process	GO:0042273	ribosomal large subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	PANTHER
NV2t024033001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t024033001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t024033001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t024034001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t024035001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t024035001.1	biological_process	GO:0061462	protein localization to lysosome	"A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph]	OMA
NV2t024035001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t024035001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t024035001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024036001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024036001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	PANTHER
NV2t024037001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t024037001.1	biological_process	GO:1903351	cellular response to dopamine	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945]	OMA
NV2t024037001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024037001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024037001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	OMA
NV2t024037001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t024038001.1	biological_process	GO:0051170	import into nucleus	"The directed movement of substances into the nucleus." [GOC:ai]	PANTHER
NV2t024038002.1	biological_process	GO:0051170	import into nucleus	"The directed movement of substances into the nucleus." [GOC:ai]	OMA
NV2t024038002.1	biological_process	GO:0051170	import into nucleus	"The directed movement of substances into the nucleus." [GOC:ai]	PANTHER
NV2t024038002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024040002.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024040002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t024040002.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024040002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t024040002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t024040002.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t024040002.1	molecular_function	GO:0004879	nuclear receptor activity	"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]	OMA
NV2t024040002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024040002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t024040002.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t024040003.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t024040003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024040003.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t024040004.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t024040004.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024040004.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t024040005.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t024040005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024040005.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t024045001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t024045001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024046001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t024046001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024048001.1	biological_process	GO:0006478	peptidyl-tyrosine sulfation	"The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172]	OMA
NV2t024048001.1	molecular_function	GO:0008476	protein-tyrosine sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]	InterPro
NV2t024048001.1	molecular_function	GO:0008476	protein-tyrosine sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]	OMA
NV2t024049001.1	biological_process	GO:0006478	peptidyl-tyrosine sulfation	"The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172]	OMA
NV2t024049001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t024049001.1	molecular_function	GO:0008476	protein-tyrosine sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]	InterPro
NV2t024049001.1	molecular_function	GO:0008476	protein-tyrosine sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]	OMA
NV2t024050001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t024050001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024050001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t024051001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024052001.1	molecular_function	GO:0003993	acid phosphatase activity	"Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]	OMA
NV2t024052001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t024052001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t024052001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t024053001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	InterPro
NV2t024053001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	OMA
NV2t024053001.1	cellular_component	GO:0005751	mitochondrial respiratory chain complex IV	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t024053001.1	molecular_function	GO:0004129	cytochrome-c oxidase activity	"Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [RHEA:11436]	OMA
NV2t024056001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t024056001.1	biological_process	GO:0045727	positive regulation of translation	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t024056001.1	biological_process	GO:1903259	exon-exon junction complex disassembly	"The disaggregation of an exon-exon junction complex into its constituent components." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:24967911]	InterPro
NV2t024056001.1	biological_process	GO:1903259	exon-exon junction complex disassembly	"The disaggregation of an exon-exon junction complex into its constituent components." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:24967911]	OMA
NV2t024056001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024056001.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	OMA
NV2t024056001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t024056001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t024057001.1	biological_process	GO:0006099	tricarboxylic acid cycle	"A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732]	OMA
NV2t024057001.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t024057001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t024057001.1	cellular_component	GO:0009353	obsolete mitochondrial oxoglutarate dehydrogenase complex	"OBSOLETE. A mitochondrial complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975]	InterPro
NV2t024057001.1	cellular_component	GO:0009353	obsolete mitochondrial oxoglutarate dehydrogenase complex	"OBSOLETE. A mitochondrial complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975]	PANTHER
NV2t024057001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t024057001.1	cellular_component	GO:1990204	oxidoreductase complex	"Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432]	OMA
NV2t024057001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t024059001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t024059001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t024059001.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	OMA
NV2t024059001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t024059001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t024059001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024059001.1	cellular_component	GO:0032045	guanyl-nucleotide exchange factor complex	"A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah]	OMA
NV2t024059001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t024059001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t024066001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t024066001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t024066001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t024066001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t024066001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t024066001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t024068001.1	biological_process	GO:0010033	response to organic substance	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676]	OMA
NV2t024068001.1	biological_process	GO:0010951	negative regulation of endopeptidase activity	"Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]	OMA
NV2t024068001.1	biological_process	GO:0031330	negative regulation of cellular catabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]	OMA
NV2t024068001.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	OMA
NV2t024068001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t024068001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t024068001.1	molecular_function	GO:0002020	protease binding	"Binding to a protease or a peptidase." [GOC:hjd]	OMA
NV2t024068001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024068001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	InterPro
NV2t024068001.1	molecular_function	GO:0008191	metalloendopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]	OMA
NV2t024070001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t024070001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t024071001.1	biological_process	GO:0006694	steroid biosynthetic process	"The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]	OMA
NV2t024071001.1	biological_process	GO:0008210	estrogen metabolic process	"The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732]	OMA
NV2t024071001.1	biological_process	GO:0042446	hormone biosynthetic process	"The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl]	OMA
NV2t024071001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024071001.1	molecular_function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	"Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor." [EC:1.1.1.62]	OMA
NV2t024071001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024071001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t024072001.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	InterPro
NV2t024072001.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	PANTHER
NV2t024072002.1	biological_process	GO:0007346	regulation of mitotic cell cycle	"Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t024072002.1	cellular_component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	"Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]	OMA
NV2t024072002.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t024072002.1	molecular_function	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	"Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]	InterPro
NV2t024072002.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t024072002.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t024072002.1	molecular_function	GO:0043130	ubiquitin binding	"Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]	OMA
NV2t024072002.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	OMA
NV2t024072002.1	molecular_function	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity	"Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810]	PANTHER
NV2t024073001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t024073001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t024073001.1	molecular_function	GO:0000030	mannosyltransferase activity	"Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm]	OMA
NV2t024073001.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t024073002.1	molecular_function	GO:0016757	glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t024077001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t024077001.1	biological_process	GO:0051966	regulation of synaptic transmission, glutamatergic	"Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]	PANTHER
NV2t024077001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024077001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024079001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024079002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024079003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024079004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024079005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024079006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024079007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024079008.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024081001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t024081001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t024081001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024081001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024081001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t024082001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t024082001.1	biological_process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	"Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]	InterPro
NV2t024082001.1	biological_process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	"Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH]	OMA
NV2t024082001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t024082001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t024085001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024085001.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	PANTHER
NV2t024087001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024087001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024087001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024087001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024088001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024088001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024088001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024090001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t024090001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t024090001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t024090001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t024090001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t024090001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024090001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t024090001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t024093001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t024094001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024094001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t024095001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024095001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024095001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024095001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024097001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t024097001.1	biological_process	GO:0008380	RNA splicing	"The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]	OMA
NV2t024097001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024097001.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	OMA
NV2t024097001.1	cellular_component	GO:0035145	exon-exon junction complex	"A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]	PANTHER
NV2t024097001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024097001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024097001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	InterPro
NV2t024097001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t024100001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024100001.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t024100002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024100002.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t024100003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024100003.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t024100004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024100004.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t024100005.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024103001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	PANTHER
NV2t024104001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024104001.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t024104002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024104002.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t024104003.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t024104003.1	biological_process	GO:0007032	endosome organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t024104003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024104003.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t024104003.1	biological_process	GO:0018126	protein hydroxylation	"The addition of a hydroxy group to a protein amino acid." [GOC:ai]	OMA
NV2t024104003.1	biological_process	GO:0018205	peptidyl-lysine modification	"The modification of peptidyl-lysine." [GOC:go_curators]	OMA
NV2t024104003.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	OMA
NV2t024104003.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t024104003.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t024104003.1	biological_process	GO:0033059	cellular pigmentation	"The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07]	OMA
NV2t024104003.1	biological_process	GO:0033363	secretory granule organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]	OMA
NV2t024104003.1	biological_process	GO:0051648	vesicle localization	"Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai]	OMA
NV2t024104003.1	biological_process	GO:0061025	membrane fusion	"The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]	OMA
NV2t024104003.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t024104003.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t024104003.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t024104003.1	cellular_component	GO:0030136	clathrin-coated vesicle	"A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]	OMA
NV2t024104003.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	OMA
NV2t024104003.1	cellular_component	GO:0031901	early endosome membrane	"The lipid bilayer surrounding an early endosome." [GOC:pz]	OMA
NV2t024104003.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	OMA
NV2t024104003.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t024104003.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t024104003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t024104003.1	molecular_function	GO:0044877	protein-containing complex binding	"Binding to a macromolecular complex." [GOC:jl]	OMA
NV2t024104004.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024104004.1	cellular_component	GO:0033263	CORVET complex	"A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]	PANTHER
NV2t024105001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024105001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024105001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024105001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024106001.1	biological_process	GO:0010890	positive regulation of sequestering of triglyceride	"Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t024106001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	OMA
NV2t024106001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	PANTHER
NV2t024106001.1	cellular_component	GO:0005811	lipid droplet	"An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb]	OMA
NV2t024106001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024106002.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	PANTHER
NV2t024107001.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t024107001.1	biological_process	GO:0070897	transcription preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]	OMA
NV2t024107001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024107001.1	cellular_component	GO:0032993	protein-DNA complex	"A macromolecular complex containing both protein and DNA molecules." [GOC:mah]	OMA
NV2t024107001.1	cellular_component	GO:0097550	transcription preinitiation complex	"A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016]	PANTHER
NV2t024107001.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t024107001.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	OMA
NV2t024108001.1	biological_process	GO:0009152	purine ribonucleotide biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t024108001.1	biological_process	GO:0034030	ribonucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t024108001.1	biological_process	GO:0034033	purine nucleoside bisphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde]	OMA
NV2t024108001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024108001.1	cellular_component	GO:0071513	phosphopantothenoylcysteine decarboxylase complex	"A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces." [GOC:jh, PMID:19915539]	PANTHER
NV2t024108001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t024108001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t024108001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t024108001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t024108001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t024109001.1	biological_process	GO:0006284	base-excision repair	"In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]	OMA
NV2t024109001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	InterPro
NV2t024109001.1	biological_process	GO:0009650	UV protection	"Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]	OMA
NV2t024109001.1	biological_process	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	OMA
NV2t024109001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t024109001.1	biological_process	GO:0070914	UV-damage excision repair	"A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]	OMA
NV2t024109001.1	biological_process	GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair	"Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477]	OMA
NV2t024109001.1	biological_process	GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair	"Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477]	PANTHER
NV2t024109001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t024109001.1	molecular_function	GO:0003684	damaged DNA binding	"Binding to damaged DNA." [GOC:jl]	OMA
NV2t024109001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t024109001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t024109001.1	molecular_function	GO:1990837	sequence-specific double-stranded DNA binding	"Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]	OMA
NV2t024111001.1	biological_process	GO:0006909	phagocytosis	"A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732]	OMA
NV2t024112001.1	biological_process	GO:0007059	chromosome segregation	"The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw]	OMA
NV2t024112001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	InterPro
NV2t024112001.1	cellular_component	GO:0000939	inner kinetochore	"The region of a kinetochore closest to centromeric DNA which contains many CENP proteins organized in various subcomplexes including CENP-C, CENP-LN, CENP-HIKM, CENP-OPQUR and CENP-TWSX, but excluding the CENP-A containing heterochromatin." [GOC:clt, PMID:10619130, PMID:11483983, PMID:32516549]	OMA
NV2t024112001.1	cellular_component	GO:0031511	Mis6-Sim4 complex	"A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182]	PANTHER
NV2t024113002.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t024113002.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t024113004.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t024113004.1	cellular_component	GO:0016591	RNA polymerase II, holoenzyme	"A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii]	OMA
NV2t024113005.1	biological_process	GO:0006368	transcription elongation by RNA polymerase II	"The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	InterPro
NV2t024114001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t024114001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	PANTHER
NV2t024117001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024117002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024117003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024121001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t024121001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t024121001.1	molecular_function	GO:0003678	DNA helicase activity	"Unwinding of a DNA helix, driven by ATP hydrolysis." [GOC:jl]	OMA
NV2t024123001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t024123001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t024123001.1	biological_process	GO:0010977	negative regulation of neuron projection development	"Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t024123001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t024123001.1	biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	"The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf]	OMA
NV2t024123001.1	biological_process	GO:1903078	positive regulation of protein localization to plasma membrane	"Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]	OMA
NV2t024123001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024123001.1	cellular_component	GO:0044306	neuron projection terminus	"The specialized, terminal region of a neuron projection such as an axon or a dendrite." [GOC:jl]	OMA
NV2t024123001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t024125001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t024125001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024127001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024127001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t024127001.1	biological_process	GO:0014902	myotube differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]	OMA
NV2t024127001.1	biological_process	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	"Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]	OMA
NV2t024127001.1	biological_process	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	"Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction." [GOC:ai]	OMA
NV2t024127001.1	biological_process	GO:0055001	muscle cell development	"The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]	OMA
NV2t024127001.1	biological_process	GO:0060537	muscle tissue development	"The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]	OMA
NV2t024127001.1	biological_process	GO:0060538	skeletal muscle organ development	"The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph]	OMA
NV2t024127001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t024127001.1	cellular_component	GO:0031965	nuclear membrane	"Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]	OMA
NV2t024127001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t024128001.1	molecular_function	GO:0001784	phosphotyrosine residue binding	"Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584]	PANTHER
NV2t024131001.1	molecular_function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]	OMA
NV2t024131001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t024131001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t024132001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t024132001.1	biological_process	GO:0019222	regulation of metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]	OMA
NV2t024132001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024132001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024132001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024132001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024134001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024137001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t024137001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t024137001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	PANTHER
NV2t024137001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t024137001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t024140001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024140001.1	biological_process	GO:0051606	detection of stimulus	"The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]	OMA
NV2t024140001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024140001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024140001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024141001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	PANTHER
NV2t024141001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t024141001.1	molecular_function	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	InterPro
NV2t024142001.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	PANTHER
NV2t024142001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t024142002.1	biological_process	GO:0031123	RNA 3'-end processing	"Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]	PANTHER
NV2t024142002.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t024143001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t024143001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	OMA
NV2t024143001.1	biological_process	GO:0006432	phenylalanyl-tRNA aminoacylation	"The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t024143001.1	biological_process	GO:0008033	tRNA processing	"The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]	OMA
NV2t024143001.1	biological_process	GO:0043039	tRNA aminoacylation	"The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]	InterPro
NV2t024143001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t024143001.1	molecular_function	GO:0000049	tRNA binding	"Binding to a transfer RNA." [GOC:ai]	OMA
NV2t024143001.1	molecular_function	GO:0004826	phenylalanine-tRNA ligase activity	"Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]	OMA
NV2t024143001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024145001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024145001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024145003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024145003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024148001.1	biological_process	GO:0030832	regulation of actin filament length	"Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah]	PANTHER
NV2t024148001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	InterPro
NV2t024148001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t024148001.1	molecular_function	GO:0003774	cytoskeletal motor activity	"Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]	OMA
NV2t024148001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024148001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024153001.1	biological_process	GO:0002084	protein depalmitoylation	"The removal of palymitoyl groups from a lipoprotein." [GOC:hjd]	OMA
NV2t024153001.1	biological_process	GO:0099175	regulation of postsynapse organization	"Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t024153001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024153001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t024153001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	PANTHER
NV2t024153001.1	molecular_function	GO:0008474	palmitoyl-(protein) hydrolase activity	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]	OMA
NV2t024153002.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	PANTHER
NV2t024153003.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	PANTHER
NV2t024154001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t024154001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t024154001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	OMA
NV2t024155001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t024155001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024155001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	PANTHER
NV2t024158001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t024159001.1	biological_process	GO:0046928	regulation of neurotransmitter secretion	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]	OMA
NV2t024159001.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t024159001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t024159001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024159002.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t024159003.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t024159004.1	cellular_component	GO:0016021	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t024161001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t024161001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t024161001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t024161001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024161001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024162001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t024162001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024163001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t024163001.1	biological_process	GO:0051453	regulation of intracellular pH	"Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t024163001.1	cellular_component	GO:0005773	vacuole	"A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]	OMA
NV2t024163001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024163001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024164001.1	biological_process	GO:0000956	nuclear-transcribed mRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]	OMA
NV2t024164001.1	biological_process	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	"The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]	InterPro
NV2t024164001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t024164001.1	biological_process	GO:1902373	negative regulation of mRNA catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865]	OMA
NV2t024164001.1	biological_process	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]	OMA
NV2t024164001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t024164001.1	cellular_component	GO:0070939	Dsl1/NZR complex	"A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722, PMID:21550981]	PANTHER
NV2t024164001.1	cellular_component	GO:0099023	vesicle tethering complex	"Any protein complex that plays a role in vesicle tethering." [GOC:dos, GOC:vw, PMID:27243008]	OMA
NV2t024164001.1	cellular_component	GO:0140534	endoplasmic reticulum protein-containing complex	"A protein complex that is part of an endoplasmic reticulum." [GOC:pg]	OMA
NV2t024164001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t024164001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024171001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024171001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	PANTHER
NV2t024171002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024171003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024171004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024171004.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	PANTHER
NV2t024173001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t024173001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024173001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t024173001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t024173001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t024173001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t024173001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t024173001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t024174001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024180001.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t024180001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t024180002.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t024180002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t024180003.1	biological_process	GO:0035461	vitamin transmembrane transport	"The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:bf]	OMA
NV2t024180003.1	biological_process	GO:0071938	vitamin A transport	"The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	OMA
NV2t024180003.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t024180003.1	biological_process	GO:0098657	import into cell	"The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos]	OMA
NV2t024180003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024180003.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t024180004.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t024180004.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t024180005.1	biological_process	GO:0071939	vitamin A import into cell	"The directed movement of vitamin A from outside of a cell, across the plasma membrane and into the cytosol. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551]	PANTHER
NV2t024180005.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t024182001.1	biological_process	GO:0006606	protein import into nucleus	"The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]	PANTHER
NV2t024185001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t024185001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024192001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	PANTHER
NV2t024194001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024194001.1	molecular_function	GO:0047865	dimethylglycine dehydrogenase activity	"Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.4, RHEA:52856]	PANTHER
NV2t024194002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024194002.1	molecular_function	GO:0047865	dimethylglycine dehydrogenase activity	"Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.4, RHEA:52856]	PANTHER
NV2t024195001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t024195001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t024195001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024195001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024195001.1	molecular_function	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t024196001.1	biological_process	GO:0032418	lysosome localization	"Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]	OMA
NV2t024196001.1	cellular_component	GO:0099078	BORC complex	"A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167]	PANTHER
NV2t024196001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t024198001.1	cellular_component	GO:0034456	UTP-C complex	"A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605]	PANTHER
NV2t024199001.1	biological_process	GO:0007286	spermatid development	"The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators]	OMA
NV2t024199001.1	biological_process	GO:0034612	response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	OMA
NV2t024199001.1	biological_process	GO:0044829	positive regulation by host of viral genome replication	"A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication." [GOC:jl]	OMA
NV2t024199001.1	biological_process	GO:0048599	oocyte development	"The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]	OMA
NV2t024199001.1	biological_process	GO:0051729	germline cell cycle switching, mitotic to meiotic cell cycle	"The process in which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]	OMA
NV2t024199001.1	cellular_component	GO:0005622	intracellular anatomical structure	"A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]	PANTHER
NV2t024199001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024199001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024199001.1	cellular_component	GO:0035770	ribonucleoprotein granule	"A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445]	OMA
NV2t024199001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024199001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024199001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024199001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024199001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024199001.1	molecular_function	GO:0034458	3'-5' RNA helicase activity	"Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis." [GOC:jp]	OMA
NV2t024199001.1	molecular_function	GO:0070063	RNA polymerase binding	"Binding to an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH]	OMA
NV2t024199001.1	molecular_function	GO:1990247	N6-methyladenosine-containing RNA reader activity	"A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]	OMA
NV2t024200001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024200001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024200001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024200001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024200001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024200001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t024200001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024203001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	OMA
NV2t024203001.1	biological_process	GO:0016072	rRNA metabolic process	"The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]	OMA
NV2t024203001.1	biological_process	GO:0016075	rRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]	PANTHER
NV2t024203001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t024203001.1	cellular_component	GO:0000178	exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t024203001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024203001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t024203001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t024203001.1	molecular_function	GO:0004540	RNA nuclease activity	"Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]	InterPro
NV2t024203001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t024204001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024205001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024205001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024205002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024205002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024211001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024211001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024212001.1	biological_process	GO:0000722	telomere maintenance via recombination	"Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777]	OMA
NV2t024212001.1	biological_process	GO:0000724	double-strand break repair via homologous recombination	"The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]	OMA
NV2t024212001.1	biological_process	GO:0022402	cell cycle process	"The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]	OMA
NV2t024212001.1	biological_process	GO:0034184	positive regulation of maintenance of mitotic sister chromatid cohesion	"Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]	OMA
NV2t024212001.1	biological_process	GO:0051984	positive regulation of chromosome segregation	"Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]	OMA
NV2t024212001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t024212001.1	cellular_component	GO:0000793	condensed chromosome	"A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]	OMA
NV2t024212001.1	cellular_component	GO:0000803	sex chromosome	"A chromosome involved in sex determination." [GOC:elh]	OMA
NV2t024212001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t024212001.1	cellular_component	GO:0030915	Smc5-Smc6 complex	"A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152]	InterPro
NV2t024212001.1	cellular_component	GO:0035861	site of double-strand break	"A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]	OMA
NV2t024212001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t024212001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t024212001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024212001.1	molecular_function	GO:0008094	ATP-dependent activity, acting on DNA	"Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt]	OMA
NV2t024212001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t024212001.1	molecular_function	GO:0140299	small molecule sensor activity	"Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879]	OMA
NV2t024213001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024213001.1	molecular_function	GO:0008201	heparin binding	"Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t024213001.1	molecular_function	GO:0048019	receptor antagonist activity	"The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor." [GOC:ceb, ISBN:0198506732]	OMA
NV2t024213001.1	molecular_function	GO:0050750	low-density lipoprotein particle receptor binding	"Binding to a low-density lipoprotein receptor." [GOC:ai]	InterPro
NV2t024213001.1	molecular_function	GO:0070325	lipoprotein particle receptor binding	"Binding to a lipoprotein particle receptor." [GOC:BHF, GOC:rl]	OMA
NV2t024215001.1	biological_process	GO:0015031	protein transport	"The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t024215001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t024215001.1	cellular_component	GO:0010008	endosome membrane	"The lipid bilayer surrounding an endosome." [GOC:mah]	OMA
NV2t024215001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024215001.1	cellular_component	GO:0032588	trans-Golgi network membrane	"The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]	OMA
NV2t024215001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t024215001.1	cellular_component	GO:0055038	recycling endosome membrane	"The lipid bilayer surrounding a recycling endosome." [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]	PANTHER
NV2t024216001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024216001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024216001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024216001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t024216002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024216002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024217001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024217001.1	molecular_function	GO:0008201	heparin binding	"Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t024217001.1	molecular_function	GO:0048019	receptor antagonist activity	"The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor." [GOC:ceb, ISBN:0198506732]	OMA
NV2t024217001.1	molecular_function	GO:0050750	low-density lipoprotein particle receptor binding	"Binding to a low-density lipoprotein receptor." [GOC:ai]	InterPro
NV2t024217001.1	molecular_function	GO:0070325	lipoprotein particle receptor binding	"Binding to a lipoprotein particle receptor." [GOC:BHF, GOC:rl]	OMA
NV2t024218001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t024218002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t024218003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t024218004.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t024219001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t024219002.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t024219002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024219003.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t024219003.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t024219003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024219004.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t024219004.1	biological_process	GO:0045943	positive regulation of transcription by RNA polymerase I	"Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t024219004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024221001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t024223001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024224001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t024224001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t024224001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t024224001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024224001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t024224001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t024224001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t024224001.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t024224001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t024225001.1	biological_process	GO:0016072	rRNA metabolic process	"The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732]	OMA
NV2t024225001.1	biological_process	GO:0016075	rRNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]	PANTHER
NV2t024225001.1	biological_process	GO:0034661	obsolete ncRNA catabolic process	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:mah]	OMA
NV2t024225001.1	molecular_function	GO:0000175	3'-5'-RNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]	OMA
NV2t024226001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024226002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024228001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024228002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024229001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024229002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t024229002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024229002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t024229003.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024231001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024232001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t024232001.1	biological_process	GO:0044743	protein transmembrane import into intracellular organelle	"The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]	OMA
NV2t024232001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t024232001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t024232001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t024232001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t024232001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t024232001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t024232001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t024233001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	OMA
NV2t024233001.1	molecular_function	GO:0008419	RNA lariat debranching enzyme activity	"Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [PMID:7519612]	PANTHER
NV2t024233001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	InterPro
NV2t024233001.1	molecular_function	GO:0016788	hydrolase activity, acting on ester bonds	"Catalysis of the hydrolysis of any ester bond." [GOC:jl]	OMA
NV2t024234001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024234001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024234001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t024235001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024235001.1	molecular_function	GO:0008227	G protein-coupled amine receptor activity	"Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]	OMA
NV2t024235001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t024235002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024235002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t024235003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024235003.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t024236001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024236001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024237001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024237001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t024238001.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	PANTHER
NV2t024238001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t024238002.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	OMA
NV2t024238002.1	biological_process	GO:0006979	response to oxidative stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]	PANTHER
NV2t024238002.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t024238002.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	InterPro
NV2t024238002.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t024239001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t024239001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t024239001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t024239001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t024240001.1	biological_process	GO:0090251	protein localization involved in establishment of planar polarity	"Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t024241001.1	biological_process	GO:0090251	protein localization involved in establishment of planar polarity	"Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t024241001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024242001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024242001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024242001.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t024243001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t024244001.1	biological_process	GO:0007064	mitotic sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]	InterPro
NV2t024244001.1	biological_process	GO:0034088	maintenance of mitotic sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]	PANTHER
NV2t024244001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024244002.1	biological_process	GO:0007064	mitotic sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]	InterPro
NV2t024244002.1	biological_process	GO:0034088	maintenance of mitotic sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]	PANTHER
NV2t024244002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024244003.1	biological_process	GO:0007064	mitotic sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]	InterPro
NV2t024244003.1	biological_process	GO:0034088	maintenance of mitotic sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]	OMA
NV2t024244003.1	biological_process	GO:0034088	maintenance of mitotic sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]	PANTHER
NV2t024244003.1	biological_process	GO:0071921	cohesin loading	"The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA." [GOC:dph, GOC:mah, GOC:vw, PMID:10882066, PMID:17113138, PMID:26687354]	OMA
NV2t024244003.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t024244003.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t024244003.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t024244003.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t024244003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024244003.1	molecular_function	GO:0047485	obsolete protein N-terminus binding	"OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t024244004.1	biological_process	GO:0007064	mitotic sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]	InterPro
NV2t024244004.1	biological_process	GO:0034088	maintenance of mitotic sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]	PANTHER
NV2t024244004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024244005.1	biological_process	GO:0007064	mitotic sister chromatid cohesion	"The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]	InterPro
NV2t024244005.1	biological_process	GO:0034088	maintenance of mitotic sister chromatid cohesion	"The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]	PANTHER
NV2t024244005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024245001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024245001.1	biological_process	GO:0006338	chromatin remodeling	"A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]	OMA
NV2t024245001.1	biological_process	GO:0006476	protein deacetylation	"The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]	OMA
NV2t024245001.1	biological_process	GO:0016570	obsolete histone modification	"OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]	OMA
NV2t024245001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t024245001.1	cellular_component	GO:0016581	NuRD complex	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]	OMA
NV2t024245001.1	cellular_component	GO:0016581	NuRD complex	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]	PANTHER
NV2t024245001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t024245001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t024245002.1	cellular_component	GO:0016581	NuRD complex	"An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]	PANTHER
NV2t024246001.1	cellular_component	GO:0031941	filamentous actin	"A two-stranded helical polymer of the protein actin." [GOC:mah]	PANTHER
NV2t024246002.1	cellular_component	GO:0031941	filamentous actin	"A two-stranded helical polymer of the protein actin." [GOC:mah]	PANTHER
NV2t024247001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024247001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024247001.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	OMA
NV2t024247001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024247001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t024247001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t024248001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t024248001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t024248001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t024248001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t024248001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t024248001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t024248001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t024248001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024248001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t024248001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t024249001.1	biological_process	GO:0060070	canonical Wnt signaling pathway	"A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [PMID:11532397, PMID:19619488]	PANTHER
NV2t024249001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024252001.1	molecular_function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	"Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [PMID:28450737]	PANTHER
NV2t024252001.1	molecular_function	GO:0070403	NAD+ binding	"Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	InterPro
NV2t024253001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024253001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024253001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t024253001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t024253001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	OMA
NV2t024253001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t024253001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t024253001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024257001.1	cellular_component	GO:1990498	mitotic spindle microtubule	"Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw]	PANTHER
NV2t024258001.1	biological_process	GO:0034553	mitochondrial respiratory chain complex II assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf]	PANTHER
NV2t024259001.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t024259001.1	biological_process	GO:0000245	spliceosomal complex assembly	"The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]	OMA
NV2t024259001.1	biological_process	GO:0006370	7-methylguanosine mRNA capping	"The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively." [GOC:mah, PMID:9266685]	OMA
NV2t024259001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	InterPro
NV2t024259001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t024259001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t024259001.1	biological_process	GO:0008334	histone mRNA metabolic process	"The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:krc, GOC:mah, PMID:17855393]	OMA
NV2t024259001.1	biological_process	GO:0016070	RNA metabolic process	"The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	InterPro
NV2t024259001.1	biological_process	GO:0030307	positive regulation of cell growth	"Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]	OMA
NV2t024259001.1	biological_process	GO:0031124	mRNA 3'-end processing	"Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	OMA
NV2t024259001.1	biological_process	GO:0031440	regulation of mRNA 3'-end processing	"Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	OMA
NV2t024259001.1	biological_process	GO:0033120	positive regulation of RNA splicing	"Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah]	OMA
NV2t024259001.1	biological_process	GO:0042789	mRNA transcription by RNA polymerase II	"The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:jl, ISBN:0321000382]	OMA
NV2t024259001.1	biological_process	GO:0048024	regulation of mRNA splicing, via spliceosome	"Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid]	OMA
NV2t024259001.1	biological_process	GO:0051099	positive regulation of binding	"Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]	OMA
NV2t024259001.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t024259001.1	biological_process	GO:0090501	obsolete RNA phosphodiester bond hydrolysis	"OBSOLETE. The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	OMA
NV2t024259001.1	biological_process	GO:1903313	positive regulation of mRNA metabolic process	"Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw]	OMA
NV2t024259001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024259001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024259001.1	cellular_component	GO:0034518	RNA cap binding complex	"A protein complex that binds to an RNA cap structure to mediate RNA processing and/or translation initiation." [GOC:mah]	OMA
NV2t024259001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t024259001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t024259001.1	molecular_function	GO:0000340	RNA 7-methylguanosine cap binding	"Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]	OMA
NV2t024259001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t024259001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024259001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t024260001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t024260001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t024260001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t024260001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t024260001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t024262001.1	biological_process	GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	"The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]	PANTHER
NV2t024262001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024262002.1	biological_process	GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	"The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]	InterPro
NV2t024262002.1	biological_process	GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	"The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]	PANTHER
NV2t024262002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024262003.1	biological_process	GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	"The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]	InterPro
NV2t024262003.1	biological_process	GO:0018406	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	"The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]	PANTHER
NV2t024262003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024263001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t024263001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024263001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024263002.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	PANTHER
NV2t024263002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024263002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024264001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	OMA
NV2t024264001.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	PANTHER
NV2t024264001.1	cellular_component	GO:0001401	SAM complex	"A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361]	InterPro
NV2t024264001.1	cellular_component	GO:0098799	outer mitochondrial membrane protein complex	"Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos]	OMA
NV2t024264001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t024264002.1	biological_process	GO:0007005	mitochondrion organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]	PANTHER
NV2t024264002.1	cellular_component	GO:0001401	SAM complex	"A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361]	InterPro
NV2t024265001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024265001.1	cellular_component	GO:0070985	transcription factor TFIIK complex	"A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993]	PANTHER
NV2t024265002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024265002.1	cellular_component	GO:0070985	transcription factor TFIIK complex	"A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993]	PANTHER
NV2t024268001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t024268001.1	molecular_function	GO:0019003	GDP binding	"Binding to GDP, guanosine 5'-diphosphate." [GOC:ai]	PANTHER
NV2t024270001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t024270001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t024270002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	InterPro
NV2t024270002.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	PANTHER
NV2t024273001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t024273002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t024274001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t024274001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t024274001.1	biological_process	GO:1904951	positive regulation of establishment of protein localization	"Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t024274001.1	biological_process	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	OMA
NV2t024274001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t024274001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024274001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t024274001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t024274001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024274001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024274001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t024274001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t024274001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t024274001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t024274001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t024274002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024274002.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t024274002.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t024274003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024274003.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t024274003.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t024274004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024274004.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t024274004.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t024279001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t024279001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024279001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024279001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t024279002.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t024279002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024280001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024281001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024284001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024284002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024284003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024284004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024285001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t024285001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024286001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024287001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024289001.1	biological_process	GO:0035725	sodium ion transmembrane transport	"A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw]	PANTHER
NV2t024289001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024289001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024289001.1	molecular_function	GO:0015280	ligand-gated sodium channel activity	"Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah]	OMA
NV2t024290001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024290001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t024290001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t024290001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t024290001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	PANTHER
NV2t024291001.1	biological_process	GO:1904108	protein localization to ciliary inversin compartment	"A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890]	PANTHER
NV2t024291001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t024291001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	OMA
NV2t024291001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024292001.1	biological_process	GO:0042760	very long-chain fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons." [PMID:7744868]	PANTHER
NV2t024292001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024292001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024292001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t024292001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t024292001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t024294001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	InterPro
NV2t024294001.1	biological_process	GO:0036159	inner dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	PANTHER
NV2t024295001.1	biological_process	GO:0008150	biological_process	"A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt]	OMA
NV2t024295001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	InterPro
NV2t024295001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	OMA
NV2t024295001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024295001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t024295002.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	InterPro
NV2t024295002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024295002.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t024295003.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	InterPro
NV2t024295003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024295003.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t024302001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t024303001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t024303002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t024305001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t024306001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t024307001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t024307001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t024307001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t024307001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024307001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t024307001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t024308001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	PANTHER
NV2t024310001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	PANTHER
NV2t024310001.1	molecular_function	GO:0003756	protein disulfide isomerase activity	"Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]	InterPro
NV2t024310001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t024310001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t024312001.1	biological_process	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	OMA
NV2t024312001.1	biological_process	GO:0030509	BMP signaling pathway	"The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827]	PANTHER
NV2t024312001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024312001.1	biological_process	GO:0048681	negative regulation of axon regeneration	"Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]	OMA
NV2t024312001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024312001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t024312001.1	molecular_function	GO:0015026	coreceptor activity	"Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]	OMA
NV2t024315001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024315001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t024315001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t024315001.1	molecular_function	GO:0015925	galactosidase activity	"Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai]	OMA
NV2t024315002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024315002.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t024319001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024319001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t024319001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t024319001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t024319002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024319002.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t024319003.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024319003.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t024320001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024320001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024320001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024320001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024325001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t024325001.1	biological_process	GO:0032447	protein urmylation	"Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw]	OMA
NV2t024325001.1	biological_process	GO:0034227	tRNA thio-modification	"The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]	InterPro
NV2t024325001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024325001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024325001.1	molecular_function	GO:0031386	protein tag activity	"A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]	OMA
NV2t024331001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t024331001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t024331001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024332001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t024332001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t024332001.1	biological_process	GO:0030890	positive regulation of B cell proliferation	"Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah]	PANTHER
NV2t024332001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t024332001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024332001.1	molecular_function	GO:0003953	NAD+ nucleosidase activity	"Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]	InterPro
NV2t024332001.1	molecular_function	GO:0003953	NAD+ nucleosidase activity	"Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]	OMA
NV2t024332001.1	molecular_function	GO:0016849	phosphorus-oxygen lyase activity	"Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t024334001.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t024336001.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t024342001.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t024342002.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t024343001.1	biological_process	GO:0019321	pentose metabolic process	"The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t024343001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t024343001.1	molecular_function	GO:0008376	acetylgalactosaminyltransferase activity	"Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732]	OMA
NV2t024343001.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t024348001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t024348001.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t024355001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t024358002.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t024358003.1	molecular_function	GO:0046556	alpha-L-arabinofuranosidase activity	"Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf]	InterPro
NV2t024359001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t024359002.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	PANTHER
NV2t024365001.1	biological_process	GO:0000727	double-strand break repair via break-induced replication	"The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]	OMA
NV2t024365001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024365001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t024365001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	OMA
NV2t024365001.1	biological_process	GO:0044773	mitotic DNA damage checkpoint signaling	"A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie]	PANTHER
NV2t024365001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024365001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t024365001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024365001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024367001.1	biological_process	GO:0000712	resolution of meiotic recombination intermediates	"The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]	OMA
NV2t024367001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t024367001.1	molecular_function	GO:0008310	single-stranded DNA 3'-5' DNA exonuclease activity	"Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358]	OMA
NV2t024368001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t024368001.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t024368001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t024368001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t024368001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024368001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024368001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t024368001.1	molecular_function	GO:0017069	snRNA binding	"Binding to a small nuclear RNA (snRNA)." [GOC:mah]	OMA
NV2t024375002.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t024375002.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t024377001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t024377001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t024377001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t024377001.1	biological_process	GO:0010639	negative regulation of organelle organization	"Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]	OMA
NV2t024377001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t024377001.1	biological_process	GO:0016242	negative regulation of macroautophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]	OMA
NV2t024377001.1	biological_process	GO:0045732	positive regulation of protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]	OMA
NV2t024377001.1	biological_process	GO:0048280	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	PANTHER
NV2t024377001.1	biological_process	GO:2000785	regulation of autophagosome assembly	"Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t024377001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t024377001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t024377001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t024377001.1	cellular_component	GO:0030134	COPII-coated ER to Golgi transport vesicle	"A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII]	OMA
NV2t024377001.1	cellular_component	GO:0030658	transport vesicle membrane	"The lipid bilayer surrounding a transport vesicle." [GOC:mah]	OMA
NV2t024377001.1	cellular_component	GO:0030662	coated vesicle membrane	"The lipid bilayer surrounding a coated vesicle." [GOC:mah]	OMA
NV2t024377001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t024377001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t024377001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t024377002.1	biological_process	GO:0048280	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	PANTHER
NV2t024377003.1	biological_process	GO:0048280	vesicle fusion with Golgi apparatus	"The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid]	PANTHER
NV2t024378002.1	biological_process	GO:0019408	dolichol biosynthetic process	"The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732]	PANTHER
NV2t024378002.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t024378004.1	biological_process	GO:0019408	dolichol biosynthetic process	"The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732]	PANTHER
NV2t024378004.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t024379001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024379002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024380001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t024380001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t024380001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t024380001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024380001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024380001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t024386001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024386001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t024386001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	OMA
NV2t024386001.1	biological_process	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	"An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component." [GOC:al, GOC:bf, PMID:16079177]	OMA
NV2t024386001.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	InterPro
NV2t024386001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024386001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024386001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024386001.1	molecular_function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655]	OMA
NV2t024386001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024389001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024389002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024389002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024389002.1	molecular_function	GO:0005044	scavenger receptor activity	"Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]	OMA
NV2t024393001.1	biological_process	GO:0070897	transcription preinitiation complex assembly	"The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC). The PIC engages the RNA polymerase on its DNA template strand and sparks polymerization of the first few RNA nucleotides." [GOC:txnOH]	InterPro
NV2t024393001.1	cellular_component	GO:0097550	transcription preinitiation complex	"A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016]	PANTHER
NV2t024393001.1	molecular_function	GO:0017025	TBP-class protein binding	"Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]	InterPro
NV2t024394001.1	biological_process	GO:0009791	post-embryonic development	"The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]	PANTHER
NV2t024394002.1	biological_process	GO:0009791	post-embryonic development	"The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]	OMA
NV2t024394002.1	biological_process	GO:0009791	post-embryonic development	"The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]	PANTHER
NV2t024394003.1	biological_process	GO:0009791	post-embryonic development	"The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]	PANTHER
NV2t024395001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t024395001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t024395001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	PANTHER
NV2t024395001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024395001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024395001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t024395001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t024395001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t024396001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t024396001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	PANTHER
NV2t024402001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t024402002.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t024410001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t024410001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t024410001.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	OMA
NV2t024410001.1	cellular_component	GO:0032040	small-subunit processome	"A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]	PANTHER
NV2t024410001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t024410001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024411001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024411001.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t024411001.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t024411002.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024411002.1	biological_process	GO:0006004	fucose metabolic process	"The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732]	InterPro
NV2t024411002.1	biological_process	GO:0016139	glycoside catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]	PANTHER
NV2t024411002.1	biological_process	GO:0019318	hexose metabolic process	"The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732]	OMA
NV2t024411002.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t024415001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t024416001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024416001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024416001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024416001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024419001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t024420001.1	biological_process	GO:0030199	collagen fibril organization	"Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194]	OMA
NV2t024420001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t024423001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t024426001.1	biological_process	GO:0006066	alcohol metabolic process	"The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732]	OMA
NV2t024426001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t024426001.1	biological_process	GO:0006720	isoprenoid metabolic process	"The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684]	OMA
NV2t024426001.1	cellular_component	GO:0031501	mannosyltransferase complex	"A complex that posseses mannosyltransferase activity." [GOC:mah]	OMA
NV2t024426001.1	cellular_component	GO:0033185	dolichol-phosphate-mannose synthase complex	"A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346]	PANTHER
NV2t024426001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	InterPro
NV2t024426001.1	molecular_function	GO:0030234	enzyme regulator activity	"Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t024427001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024427001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024427001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t024427001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t024427001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t024435004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024436001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t024436001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t024436001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024436002.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	OMA
NV2t024436002.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t024436002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t024436002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024436002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024436002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024437001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t024437001.1	biological_process	GO:0010457	centriole-centriole cohesion	"The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]	OMA
NV2t024437001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	OMA
NV2t024437001.1	biological_process	GO:1902017	regulation of cilium assembly	"Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]	OMA
NV2t024437001.1	biological_process	GO:1902017	regulation of cilium assembly	"Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545]	PANTHER
NV2t024437001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t024437001.1	cellular_component	GO:0005814	centriole	"A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]	OMA
NV2t024437001.1	cellular_component	GO:0036126	sperm flagellum	"A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]	OMA
NV2t024437001.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t024442001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t024442001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t024444001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024444001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t024444001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024444001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024444001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024444001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024444001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t024446001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	InterPro
NV2t024446001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t024446001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t024457001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024459001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t024459001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024459001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t024459001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t024461001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t024461001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t024461001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t024461001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024461001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024463001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	OMA
NV2t024463001.1	cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]	PANTHER
NV2t024463001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024464001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	InterPro
NV2t024464001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t024464001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t024464001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	OMA
NV2t024465001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024465001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024465001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024465001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024465001.1	molecular_function	GO:0004523	RNA-DNA hybrid ribonuclease activity	"Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]	OMA
NV2t024467001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024468001.1	cellular_component	GO:0070062	extracellular exosome	"A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]	PANTHER
NV2t024468001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	InterPro
NV2t024471001.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	InterPro
NV2t024471001.1	biological_process	GO:0070478	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	"The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [PMID:12769863]	PANTHER
NV2t024471001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024471002.1	biological_process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	"The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]	OMA
NV2t024471002.1	biological_process	GO:0000291	obsolete nuclear-transcribed mRNA catabolic process, exonucleolytic	"OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]	OMA
NV2t024471002.1	biological_process	GO:0006401	RNA catabolic process	"The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]	InterPro
NV2t024471002.1	biological_process	GO:0070478	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	"The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [PMID:12769863]	PANTHER
NV2t024471002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024471002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t024471002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t024471002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t024471002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024471002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024472001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t024472001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024472001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t024472001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t024473001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t024473001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t024473001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t024473001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t024473001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t024474001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024474002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024476001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t024476001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024477001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024477001.1	molecular_function	GO:0004849	uridine kinase activity	"Catalysis of the reaction: ATP + uridine = ADP + UMP." [RHEA:16825]	OMA
NV2t024477001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024477001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t024477001.1	molecular_function	GO:0050262	ribosylnicotinamide kinase activity	"Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide." [EC:2.7.1.22, PMID:17914902, RHEA:14017]	PANTHER
NV2t024480001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	OMA
NV2t024480001.1	biological_process	GO:0034472	snRNA 3'-end processing	"Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]	PANTHER
NV2t024480001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024480001.1	cellular_component	GO:0032039	integrator complex	"A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]	OMA
NV2t024481001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t024481002.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t024484001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t024485001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024485001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024485001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t024486001.1	biological_process	GO:0033617	mitochondrial cytochrome c oxidase assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]	PANTHER
NV2t024486001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024487001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t024487001.1	biological_process	GO:0051131	chaperone-mediated protein complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]	PANTHER
NV2t024487001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t024487001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024487001.1	cellular_component	GO:0016272	prefoldin complex	"A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]	OMA
NV2t024487001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t024487001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t024487001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t024493001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024493001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t024493001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024493001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024493002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024493002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t024493002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024493003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024493003.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024495001.1	biological_process	GO:0006828	manganese ion transport	"The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t024495001.1	biological_process	GO:0051480	regulation of cytosolic calcium ion concentration	"Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph]	OMA
NV2t024495001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024495001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t024495001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024495001.1	cellular_component	GO:0034703	cation channel complex	"An ion channel complex through which cations pass." [GOC:mah]	OMA
NV2t024495001.1	molecular_function	GO:0015279	store-operated calcium channel activity	"A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]	OMA
NV2t024495001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t024495001.1	molecular_function	GO:0043178	alcohol binding	"Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]	OMA
NV2t024495001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t024495002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024495002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t024495002.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t024495003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024495003.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t024495003.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t024496001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t024496002.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t024496003.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t024496004.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t024497001.1	biological_process	GO:1903358	regulation of Golgi organization	"Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788]	PANTHER
NV2t024497001.1	cellular_component	GO:0005815	microtubule organizing center	"An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center]	InterPro
NV2t024501001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024501001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024501001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024501001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024501001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024501001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024503001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024503001.1	molecular_function	GO:0051864	histone H3K36 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16362057]	OMA
NV2t024503001.1	molecular_function	GO:0051864	histone H3K36 demethylase activity	"Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16362057]	PANTHER
NV2t024504001.1	biological_process	GO:0032259	methylation	"The process in which a methyl group is covalently attached to a molecule." [GOC:mah]	InterPro
NV2t024504001.1	biological_process	GO:0097309	obsolete cap1 mRNA methylation	"OBSOLETE. Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356]	PANTHER
NV2t024507001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024507001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t024507001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t024507001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024509001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024509001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t024509001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024511001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024513001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	InterPro
NV2t024513001.1	biological_process	GO:0071704	organic substance metabolic process	"The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah]	OMA
NV2t024513001.1	molecular_function	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	"Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]	OMA
NV2t024527001.1	biological_process	GO:0006874	intracellular calcium ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell." [GOC:ceb, GOC:mah]	OMA
NV2t024527001.1	biological_process	GO:0090150	establishment of protein localization to membrane	"The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t024527001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t024527001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t024527001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024527001.1	molecular_function	GO:0015662	P-type ion transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]	OMA
NV2t024527001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t024527001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t024527001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	OMA
NV2t024527001.1	molecular_function	GO:0140318	protein transporter activity	"Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423]	OMA
NV2t024527001.1	molecular_function	GO:0140358	P-type transmembrane transporter activity	"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]	InterPro
NV2t024530001.1	biological_process	GO:0006139	nucleobase-containing compound metabolic process	"Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]	OMA
NV2t024530001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024530001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	OMA
NV2t024533001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024533001.1	molecular_function	GO:1990430	extracellular matrix protein binding	"Binding to a protein that is part of an extracellular matrix." [PMID:22355679]	PANTHER
NV2t024535001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t024535001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t024535002.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t024535002.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	InterPro
NV2t024538001.1	biological_process	GO:0007130	synaptonemal complex assembly	"The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]	InterPro
NV2t024538001.1	biological_process	GO:0007130	synaptonemal complex assembly	"The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732]	OMA
NV2t024538001.1	cellular_component	GO:0000801	central element	"A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh]	OMA
NV2t024540001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t024540002.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t024540002.1	biological_process	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	"The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783]	OMA
NV2t024540002.1	biological_process	GO:0048167	regulation of synaptic plasticity	"A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]	OMA
NV2t024540002.1	biological_process	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t024540002.1	biological_process	GO:0048638	regulation of developmental growth	"Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]	OMA
NV2t024540002.1	biological_process	GO:0051960	regulation of nervous system development	"Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]	OMA
NV2t024540002.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t024540002.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t024540002.1	biological_process	GO:0090129	positive regulation of synapse maturation	"Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t024540002.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t024540002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t024540002.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t024540002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t024540003.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t024540003.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	InterPro
NV2t024542001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024542001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024542001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t024543001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t024543001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024544001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t024544001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024546001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024546001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024546001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024546001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024553001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t024556001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024556001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024566001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024568001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t024569001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024570001.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t024570002.1	biological_process	GO:1905515	non-motile cilium assembly	"The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834]	PANTHER
NV2t024571001.1	biological_process	GO:0000226	microtubule cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]	OMA
NV2t024571001.1	biological_process	GO:0006839	mitochondrial transport	"Transport of substances into, out of or within a mitochondrion." [GOC:ai]	OMA
NV2t024571001.1	biological_process	GO:0021952	central nervous system projection neuron axonogenesis	"Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]	OMA
NV2t024571001.1	biological_process	GO:0106027	neuron projection organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923]	OMA
NV2t024571001.1	biological_process	GO:1990535	neuron projection maintenance	"The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:kmv, PMID:25359212]	PANTHER
NV2t024571001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t024574001.1	biological_process	GO:0000077	DNA damage checkpoint signaling	"A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah]	OMA
NV2t024574001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024574001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t024574001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024574001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	OMA
NV2t024578001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t024581001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t024581001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t024581001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t024581001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024581001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t024581001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t024581001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t024581001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t024582001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024582001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024582001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t024582001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t024583001.1	biological_process	GO:0035590	purinergic nucleotide receptor signaling pathway	"The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:9755289]	OMA
NV2t024583001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024583001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024583002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024584001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024584001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024584001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024584001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024587001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024587001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024587001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024590001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024590001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024590001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024591001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024591002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024592001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t024592001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t024592001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t024592001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t024592001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t024592001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t024592002.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t024592002.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t024594001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t024594001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	OMA
NV2t024594001.1	cellular_component	GO:1902636	kinociliary basal body	"A ciliary basal body that is part of a kinocilium." [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574]	PANTHER
NV2t024594001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024594001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024594001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t024594001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t024594001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t024595001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t024595001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	PANTHER
NV2t024595001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024595001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t024595001.1	molecular_function	GO:0004300	enoyl-CoA hydratase activity	"Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." [EC:4.2.1.17]	OMA
NV2t024596001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t024596001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t024596001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024596001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t024596001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024599001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024599001.1	molecular_function	GO:0030159	signaling receptor complex adaptor activity	"The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]	PANTHER
NV2t024603001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t024603001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t024603001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t024603001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t024603001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t024603001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024603001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t024603002.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t024603002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t024603002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024607001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t024607001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024608001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t024608001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t024608001.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t024608001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t024608001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t024608001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024608001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t024608002.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t024608002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t024608002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024608003.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t024608003.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t024608003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024608004.1	molecular_function	GO:0008395	steroid hydroxylase activity	"Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544]	PANTHER
NV2t024608004.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t024608004.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024611001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024611001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024618001.1	biological_process	GO:0034454	microtubule anchoring at centrosome	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]	PANTHER
NV2t024618001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024618002.1	biological_process	GO:0034454	microtubule anchoring at centrosome	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]	PANTHER
NV2t024618002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024618003.1	biological_process	GO:0034454	microtubule anchoring at centrosome	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]	PANTHER
NV2t024618004.1	biological_process	GO:0034454	microtubule anchoring at centrosome	"Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]	PANTHER
NV2t024619001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t024620001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t024621001.1	biological_process	GO:0045053	protein retention in Golgi apparatus	"The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]	PANTHER
NV2t024622001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t024622001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	InterPro
NV2t024622001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t024622001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t024622001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024622002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	InterPro
NV2t024622002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t024622002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024625001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t024625001.1	molecular_function	GO:0016407	acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]	OMA
NV2t024625001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t024628001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024629001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024629002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024631001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024632001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t024632001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t024632001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024632001.1	cellular_component	GO:0030687	preribosome, large subunit precursor	"A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]	PANTHER
NV2t024632001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t024632001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	InterPro
NV2t024632001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t024633001.1	biological_process	GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair	"Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477]	PANTHER
NV2t024634001.1	biological_process	GO:0006879	intracellular iron ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t024634001.1	biological_process	GO:0036296	response to increased oxygen levels	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al]	OMA
NV2t024634001.1	biological_process	GO:0071453	cellular response to oxygen levels	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah]	OMA
NV2t024634001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t024634001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024634001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024634001.1	cellular_component	GO:0016471	vacuolar proton-transporting V-type ATPase complex	"A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]	OMA
NV2t024634001.1	molecular_function	GO:0019899	enzyme binding	"Binding to an enzyme, a protein with catalytic activity." [GOC:jl]	OMA
NV2t024634001.1	molecular_function	GO:0046961	proton-transporting ATPase activity, rotational mechanism	"Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721]	OMA
NV2t024635001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024635001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t024635001.1	biological_process	GO:0006491	N-glycan processing	"The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]	OMA
NV2t024635001.1	biological_process	GO:0006516	glycoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t024635001.1	biological_process	GO:0006517	protein deglycosylation	"The removal of sugar residues from a glycosylated protein." [GOC:mah]	OMA
NV2t024635001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t024635001.1	biological_process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	"The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966]	PANTHER
NV2t024635001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024635001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024635001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024635001.1	molecular_function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	"Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655]	OMA
NV2t024635001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024636001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t024636001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024636001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024636001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t024636001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t024639001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t024642001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t024643001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t024643001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024643001.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t024643001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	InterPro
NV2t024643001.1	cellular_component	GO:0045211	postsynaptic membrane	"A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]	OMA
NV2t024643001.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t024643001.1	molecular_function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	"Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]	OMA
NV2t024643001.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	PANTHER
NV2t024645001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024646001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024647001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024647001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024647001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024647001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t024649001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024649001.1	molecular_function	GO:0015179	L-amino acid transmembrane transporter activity	"Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024650001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t024650001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t024650001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	InterPro
NV2t024650001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t024650001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t024650001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t024650001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024650001.1	molecular_function	GO:0001784	phosphotyrosine residue binding	"Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584]	OMA
NV2t024650001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	InterPro
NV2t024650001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t024650001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024651001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024651002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024653001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024653001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t024654001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t024654001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024654001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t024654001.1	molecular_function	GO:0005035	death receptor activity	"Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death." [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]	OMA
NV2t024654001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024654001.1	molecular_function	GO:0015026	coreceptor activity	"Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]	OMA
NV2t024654001.1	molecular_function	GO:0043121	neurotrophin binding	"Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl]	OMA
NV2t024654001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t024655001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024655001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t024658001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024658001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t024658002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024658002.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t024658003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024658003.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t024658004.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t024658005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024658005.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t024659001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024659002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024660001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t024660001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t024660001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t024660002.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t024660002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t024660002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t024660002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t024660002.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t024660002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t024660002.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t024660003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t024660003.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t024660003.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t024661001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024662001.1	cellular_component	GO:0097014	ciliary plasm	"All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]	PANTHER
NV2t024662001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024662002.1	cellular_component	GO:0097014	ciliary plasm	"All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]	PANTHER
NV2t024662002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024664001.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t024664001.1	molecular_function	GO:0047389	glycerophosphocholine phosphodiesterase activity	"Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN]	PANTHER
NV2t024664002.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t024664002.1	molecular_function	GO:0047389	glycerophosphocholine phosphodiesterase activity	"Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN]	PANTHER
NV2t024664003.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t024664004.1	molecular_function	GO:0008081	phosphoric diester hydrolase activity	"Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-]	InterPro
NV2t024664004.1	molecular_function	GO:0047389	glycerophosphocholine phosphodiesterase activity	"Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN]	PANTHER
NV2t024665001.1	biological_process	GO:0006486	protein glycosylation	"A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr]	OMA
NV2t024665001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024665001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t024665001.1	molecular_function	GO:0016758	hexosyltransferase activity	"Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t024666001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t024666001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024666001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024666002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t024666002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024667001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	InterPro
NV2t024667001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024667001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024670001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024670001.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t024670002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024670002.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t024670003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024670003.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t024670004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024670004.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t024670005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024670005.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t024670006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024670006.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t024670007.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024670007.1	molecular_function	GO:0070577	lysine-acetylated histone binding	"Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]	PANTHER
NV2t024672001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t024680001.1	molecular_function	GO:1901981	phosphatidylinositol phosphate binding	"Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487]	PANTHER
NV2t024694001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t024694001.1	biological_process	GO:0016036	cellular response to phosphate starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl]	PANTHER
NV2t024694001.1	biological_process	GO:0035435	phosphate ion transmembrane transport	"The process in which a phosphate is transported across a membrane." [GOC:vw]	OMA
NV2t024694001.1	biological_process	GO:0046718	symbiont entry into host cell	"The process by which a symbiont breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the symbiont or its genome is released into the host cell." [GOC:jl]	OMA
NV2t024694001.1	biological_process	GO:0055082	intracellular chemical homeostasis	"A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell." [GOC:isa_complete, GOC:jid]	OMA
NV2t024694001.1	biological_process	GO:0098771	inorganic ion homeostasis	"Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos]	OMA
NV2t024694001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t024694001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024694001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024694001.1	molecular_function	GO:0015103	inorganic anion transmembrane transporter activity	"Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t024694001.1	molecular_function	GO:0015562	efflux transmembrane transporter activity	"Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t024694001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t024694001.1	molecular_function	GO:0043178	alcohol binding	"Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]	OMA
NV2t024694002.1	biological_process	GO:0016036	cellular response to phosphate starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl]	PANTHER
NV2t024694002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024694003.1	biological_process	GO:0016036	cellular response to phosphate starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl]	PANTHER
NV2t024694003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024694004.1	biological_process	GO:0016036	cellular response to phosphate starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl]	PANTHER
NV2t024694004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024695001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024695001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t024695002.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t024695002.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t024695002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024695002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024695002.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t024697001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024697001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t024697001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t024697001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024699001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024699001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t024699001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t024699001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024699002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024699002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t024699002.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024701001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t024701001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t024701001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t024703001.1	biological_process	GO:0071929	alpha-tubulin acetylation	"The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050]	InterPro
NV2t024703001.1	biological_process	GO:0071929	alpha-tubulin acetylation	"The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050]	PANTHER
NV2t024706001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t024706001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024707001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024707001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t024709001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024712001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024712001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t024716001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024716001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t024717001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t024717001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t024717001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024717001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024717001.1	cellular_component	GO:0098794	postsynapse	"The part of a synapse that is part of the post-synaptic cell." [GOC:dos]	PANTHER
NV2t024718001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024718001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024718001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t024718002.1	biological_process	GO:0030036	actin cytoskeleton organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t024718002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024718002.1	cellular_component	GO:0030054	cell junction	"A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264]	OMA
NV2t024718002.1	cellular_component	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	OMA
NV2t024718002.1	cellular_component	GO:0042995	cell projection	"A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t024718002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024718002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024718002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024718002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t024718002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t024718003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024718003.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t024719001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t024719001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t024719001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t024720001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t024720001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t024720001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t024720001.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	OMA
NV2t024720001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t024720001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t024720002.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t024720002.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t024720003.1	cellular_component	GO:0030131	clathrin adaptor complex	"A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]	InterPro
NV2t024720003.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	PANTHER
NV2t024721001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t024721001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024721001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024721001.1	cellular_component	GO:0031090	organelle membrane	"A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah]	OMA
NV2t024721001.1	cellular_component	GO:0031985	Golgi cisterna	"Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]	OMA
NV2t024721001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t024722001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t024725001.1	biological_process	GO:0030150	protein import into mitochondrial matrix	"The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]	PANTHER
NV2t024726001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t024726001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	OMA
NV2t024726001.1	biological_process	GO:0072583	clathrin-dependent endocytosis	"An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965]	PANTHER
NV2t024726001.1	cellular_component	GO:0030130	clathrin coat of trans-Golgi network vesicle	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]	OMA
NV2t024726001.1	cellular_component	GO:0030132	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	InterPro
NV2t024726001.1	cellular_component	GO:0030132	clathrin coat of coated pit	"The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]	OMA
NV2t024726001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t024726001.1	molecular_function	GO:0032050	clathrin heavy chain binding	"Binding to a clathrin heavy chain." [GOC:mah]	OMA
NV2t024727001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t024727001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t024727001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t024729001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729002.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729004.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729004.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729005.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729005.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729006.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729006.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729006.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729007.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729007.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729007.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729008.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729008.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729008.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729009.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729009.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024729009.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729009.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t024729009.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t024729009.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729010.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729010.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729010.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729011.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729011.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729012.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729013.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729013.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729014.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729015.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729015.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729015.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729016.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729016.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729016.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729017.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729017.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024729018.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024729018.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t024729018.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t024730001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t024730001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t024730001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t024730001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t024730001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t024730001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t024730001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t024731001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024732001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t024732002.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t024732002.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t024738001.1	biological_process	GO:0006027	glycosaminoglycan catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]	InterPro
NV2t024738001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	InterPro
NV2t024738001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t024740001.1	biological_process	GO:0071705	nitrogen compound transport	"The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t024740001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024740001.1	molecular_function	GO:0015103	inorganic anion transmembrane transporter activity	"Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai]	OMA
NV2t024740001.1	molecular_function	GO:1901702	salt transmembrane transporter activity	"Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie]	OMA
NV2t024741002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024742001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024747001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024747002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024747003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024751001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t024751001.1	cellular_component	GO:0071014	post-mRNA release spliceosomal complex	"A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]	PANTHER
NV2t024751001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024752001.1	biological_process	GO:0001666	response to hypoxia	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]	OMA
NV2t024752001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t024752001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t024752001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	OMA
NV2t024752001.1	biological_process	GO:0032091	negative regulation of protein binding	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t024752001.1	biological_process	GO:0032092	positive regulation of protein binding	"Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t024752001.1	biological_process	GO:0032465	regulation of cytokinesis	"Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]	OMA
NV2t024752001.1	biological_process	GO:0034249	negative regulation of amide metabolic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]	OMA
NV2t024752001.1	biological_process	GO:0035304	regulation of protein dephosphorylation	"Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]	OMA
NV2t024752001.1	biological_process	GO:0035306	positive regulation of dephosphorylation	"Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]	OMA
NV2t024752001.1	biological_process	GO:0042177	negative regulation of protein catabolic process	"Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082]	OMA
NV2t024752001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t024752001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t024752001.1	biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024752001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	OMA
NV2t024752001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t024752001.1	biological_process	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t024752001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t024752001.1	biological_process	GO:0051443	positive regulation of ubiquitin-protein transferase activity	"Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb]	OMA
NV2t024752001.1	biological_process	GO:0060393	obsolete regulation of pathway-restricted SMAD protein phosphorylation	"OBSOLETE. Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]	OMA
NV2t024752001.1	biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]	OMA
NV2t024752001.1	biological_process	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	"Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]	OMA
NV2t024752001.1	biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	"Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb]	OMA
NV2t024752001.1	biological_process	GO:0090287	regulation of cellular response to growth factor stimulus	"Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]	OMA
NV2t024752001.1	biological_process	GO:1900180	regulation of protein localization to nucleus	"Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie]	OMA
NV2t024752001.1	biological_process	GO:2000146	negative regulation of cell motility	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah]	OMA
NV2t024752001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024752001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t024752001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t024752001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t024752001.1	cellular_component	GO:0098978	glutamatergic synapse	"A synapse that uses glutamate as a neurotransmitter." [GOC:dos]	OMA
NV2t024752001.1	cellular_component	GO:0099524	postsynaptic cytosol	"The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos]	OMA
NV2t024752001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t024752001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t024752001.1	molecular_function	GO:0003774	cytoskeletal motor activity	"Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]	OMA
NV2t024752001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024752001.1	molecular_function	GO:0008013	beta-catenin binding	"Binding to a catenin beta subunit." [GOC:bf]	OMA
NV2t024752001.1	molecular_function	GO:0031434	mitogen-activated protein kinase kinase binding	"Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase." [GOC:mah]	OMA
NV2t024752001.1	molecular_function	GO:0032794	GTPase activating protein binding	"Binding to a GTPase activating protein." [GOC:nln]	OMA
NV2t024752001.1	molecular_function	GO:0050815	phosphoserine residue binding	"Binding to a phosphorylated serine residue within a protein." [GOC:ai]	OMA
NV2t024764001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t024764001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t024764001.1	biological_process	GO:0031507	heterochromatin formation	"An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [PMID:25192661, PMID:33827924]	OMA
NV2t024764001.1	biological_process	GO:0031507	heterochromatin formation	"An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [PMID:25192661, PMID:33827924]	PANTHER
NV2t024764001.1	cellular_component	GO:0008622	epsilon DNA polymerase complex	"A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]	OMA
NV2t024764001.1	cellular_component	GO:0008623	CHRAC	"An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192]	OMA
NV2t024764001.1	molecular_function	GO:0031490	chromatin DNA binding	"Binding to DNA that is assembled into chromatin." [GOC:mah]	OMA
NV2t024764001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t024764001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t024765001.1	cellular_component	GO:0005956	protein kinase CK2 complex	"A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779]	OMA
NV2t024765001.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	InterPro
NV2t024765001.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	OMA
NV2t024765001.1	molecular_function	GO:0019887	protein kinase regulator activity	"Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]	PANTHER
NV2t024767001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t024767001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t024767001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t024767001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t024767001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t024767001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t024767001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t024767001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t024767001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t024771001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t024774001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024774001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024774001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t024775001.1	biological_process	GO:0007052	mitotic spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah]	OMA
NV2t024775001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t024775001.1	cellular_component	GO:0000159	protein phosphatase type 2A complex	"A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]	OMA
NV2t024775001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024775001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024775001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t024775001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t024775001.1	molecular_function	GO:0019211	phosphatase activator activity	"Binds to and increases the activity of a phosphatase." [GOC:ai]	InterPro
NV2t024775001.1	molecular_function	GO:0019888	protein phosphatase regulator activity	"Binds to and modulates the activity of a protein phosphatase." [GOC:ai]	OMA
NV2t024775002.1	molecular_function	GO:0019211	phosphatase activator activity	"Binds to and increases the activity of a phosphatase." [GOC:ai]	InterPro
NV2t024775003.1	molecular_function	GO:0019211	phosphatase activator activity	"Binds to and increases the activity of a phosphatase." [GOC:ai]	InterPro
NV2t024776001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t024776001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t024776001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t024776001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024776001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t024776001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t024776002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t024776002.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t024779001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t024779001.1	biological_process	GO:0002253	activation of immune response	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t024779001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024779001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024779001.1	biological_process	GO:0006956	complement activation	"Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149]	InterPro
NV2t024779001.1	biological_process	GO:0006959	humoral immune response	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]	OMA
NV2t024779001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t024779001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t024781001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024782001.1	biological_process	GO:0008219	cell death	"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]	OMA
NV2t024782001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t024782001.1	biological_process	GO:0031670	cellular response to nutrient	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah]	OMA
NV2t024782001.1	biological_process	GO:0071310	cellular response to organic substance	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah]	OMA
NV2t024782001.1	biological_process	GO:1901655	cellular response to ketone	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t024782001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024782001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t024782001.1	molecular_function	GO:0003958	NADPH-hemoprotein reductase activity	"Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4]	InterPro
NV2t024782001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t024782001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	InterPro
NV2t024782001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t024782001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024782001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t024782001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t024782001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	PANTHER
NV2t024782001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t024786001.1	biological_process	GO:0007601	visual perception	"The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]	OMA
NV2t024786001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t024786001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024786001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024789001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t024789001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024789001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024789001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024789001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t024789001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t024789001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t024790001.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t024790001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024790001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024797001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t024797001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t024797001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t024797001.1	biological_process	GO:0009607	response to biotic stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]	OMA
NV2t024797001.1	biological_process	GO:0009968	negative regulation of signal transduction	"Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm]	OMA
NV2t024797001.1	biological_process	GO:0010604	positive regulation of macromolecule metabolic process	"Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]	OMA
NV2t024797001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t024797001.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t024797001.1	biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	"The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]	OMA
NV2t024797001.1	biological_process	GO:0031333	negative regulation of protein-containing complex assembly	"Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]	OMA
NV2t024797001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t024797001.1	biological_process	GO:0035437	maintenance of protein localization in endoplasmic reticulum	"Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum." [GOC:bf, GOC:vw]	OMA
NV2t024797001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t024797001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t024797001.1	biological_process	GO:0051173	obsolete positive regulation of nitrogen compound metabolic process	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]	OMA
NV2t024797001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t024797001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t024797001.1	biological_process	GO:0072594	establishment of protein localization to organelle	"The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah]	OMA
NV2t024797001.1	biological_process	GO:0080090	regulation of primary metabolic process	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]	OMA
NV2t024797001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t024797001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024797001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t024797001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t024797001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t024797001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t024797001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024797001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t024797001.1	cellular_component	GO:0034663	endoplasmic reticulum chaperone complex	"A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]	OMA
NV2t024797001.1	cellular_component	GO:0071944	cell periphery	"The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures." [GOC:pdt]	OMA
NV2t024797001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024797001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t024797001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t024797001.1	molecular_function	GO:0031072	heat shock protein binding	"Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]	OMA
NV2t024797001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t024797001.1	molecular_function	GO:0044183	protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009]	OMA
NV2t024797001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t024797001.1	molecular_function	GO:0140662	ATP-dependent protein folding chaperone	"Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453]	InterPro
NV2t024799001.1	biological_process	GO:0010212	response to ionizing radiation	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]	OMA
NV2t024799001.1	biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	"Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]	OMA
NV2t024799001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	OMA
NV2t024799001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	OMA
NV2t024799001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024799001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t024799001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t024800001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024800001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t024800001.1	biological_process	GO:0031061	obsolete negative regulation of histone methylation	"OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]	OMA
NV2t024800001.1	biological_process	GO:0043966	obsolete histone H3 acetylation	"OBSOLETE. The modification of histone H3 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t024800001.1	biological_process	GO:0043967	obsolete histone H4 acetylation	"OBSOLETE. The modification of histone H4 by the addition of an acetyl group." [GOC:jl]	OMA
NV2t024800001.1	biological_process	GO:0045815	transcription initiation-coupled chromatin remodeling	"An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA." [PMID:34414474]	OMA
NV2t024800001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t024800001.1	biological_process	GO:0051302	regulation of cell division	"Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]	OMA
NV2t024800001.1	biological_process	GO:0051568	obsolete histone H3-K4 methylation	"OBSOLETE. The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr]	OMA
NV2t024800001.1	biological_process	GO:0051571	obsolete positive regulation of histone H3-K4 methylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah]	OMA
NV2t024800001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t024800001.1	cellular_component	GO:0044545	NSL complex	"A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]	OMA
NV2t024800001.1	cellular_component	GO:0044665	MLL1/2 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t024800001.1	cellular_component	GO:0044666	MLL3/4 complex	"A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]	OMA
NV2t024800001.1	cellular_component	GO:0048188	Set1C/COMPASS complex	"A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538]	OMA
NV2t024800001.1	cellular_component	GO:0140672	ATAC complex	"A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation." [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424]	OMA
NV2t024800001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024800001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t024800001.1	molecular_function	GO:0042800	histone H3K4 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein." [PMID:12086618]	OMA
NV2t024800002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024800003.1	cellular_component	GO:0005730	nucleolus	"A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]	PANTHER
NV2t024800003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024801001.1	biological_process	GO:0006525	arginine metabolic process	"The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators]	OMA
NV2t024801001.1	biological_process	GO:0006526	arginine biosynthetic process	"The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ISBN:0198506732]	InterPro
NV2t024801001.1	biological_process	GO:0006526	arginine biosynthetic process	"The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ISBN:0198506732]	PANTHER
NV2t024801001.1	biological_process	GO:0006575	cellular modified amino acid metabolic process	"The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t024801001.1	biological_process	GO:0007623	circadian rhythm	"Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]	OMA
NV2t024801001.1	biological_process	GO:0009066	aspartate family amino acid metabolic process	"The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]	OMA
NV2t024801001.1	biological_process	GO:0009084	glutamine family amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]	OMA
NV2t024801001.1	biological_process	GO:0022408	negative regulation of cell-cell adhesion	"Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t024801001.1	biological_process	GO:0033554	cellular response to stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]	OMA
NV2t024801001.1	biological_process	GO:0043604	amide biosynthetic process	"The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators]	OMA
NV2t024801001.1	biological_process	GO:0043648	dicarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]	OMA
NV2t024801001.1	biological_process	GO:0045429	positive regulation of nitric oxide biosynthetic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]	OMA
NV2t024801001.1	biological_process	GO:0072350	tricarboxylic acid metabolic process	"The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [GOC:mah]	OMA
NV2t024801001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024801001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024801001.1	molecular_function	GO:0004055	argininosuccinate synthase activity	"Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5]	InterPro
NV2t024801001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024801001.1	molecular_function	GO:0016597	amino acid binding	"Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t024801001.1	molecular_function	GO:0016879	ligase activity, forming carbon-nitrogen bonds	"Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah]	OMA
NV2t024801001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t024802001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024802001.1	molecular_function	GO:0003730	mRNA 3'-UTR binding	"Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah]	OMA
NV2t024802001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t024802001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024802001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t024802001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t024802001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t024802001.1	molecular_function	GO:0070402	NADPH binding	"Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]	PANTHER
NV2t024804001.1	biological_process	GO:0007131	reciprocal meiotic recombination	"The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]	OMA
NV2t024804001.1	cellular_component	GO:0000795	synaptonemal complex	"A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh]	OMA
NV2t024804001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t024804001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t024805001.1	biological_process	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	InterPro
NV2t024805001.1	biological_process	GO:0010038	response to metal ion	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]	OMA
NV2t024806001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024806001.1	biological_process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	PANTHER
NV2t024806001.1	cellular_component	GO:0032021	NELF complex	"A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062]	OMA
NV2t024806001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024806001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024806001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t024806002.1	biological_process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	PANTHER
NV2t024806002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024806002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024807001.1	biological_process	GO:0006915	apoptotic process	"A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]	OMA
NV2t024807001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t024807001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t024807001.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	OMA
NV2t024807001.1	biological_process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	"Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	PANTHER
NV2t024808001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t024808001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t024808001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t024808001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t024808001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024808001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024808001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024808001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t024809001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024809001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024809001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t024809002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024809003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024809004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024811001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024811001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024811001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t024812001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t024812001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t024812001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t024813001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t024813001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t024813001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024814001.1	biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]	PANTHER
NV2t024814002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024814002.1	biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	"The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]	PANTHER
NV2t024814002.1	biological_process	GO:0042996	regulation of Golgi to plasma membrane protein transport	"Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]	OMA
NV2t024814002.1	biological_process	GO:0045597	positive regulation of cell differentiation	"Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]	OMA
NV2t024814002.1	biological_process	GO:0048566	embryonic digestive tract development	"The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators]	OMA
NV2t024814002.1	biological_process	GO:0051224	negative regulation of protein transport	"Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t024814002.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t024814002.1	biological_process	GO:0060541	respiratory system development	"The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]	OMA
NV2t024814002.1	biological_process	GO:2000026	regulation of multicellular organismal development	"Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]	OMA
NV2t024814002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t024814002.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t024814002.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t024814002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024816001.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	OMA
NV2t024816001.1	biological_process	GO:0008593	regulation of Notch signaling pathway	"Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]	OMA
NV2t024816001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t024816001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	InterPro
NV2t024816001.1	molecular_function	GO:0046922	peptide-O-fucosyltransferase activity	"Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]	OMA
NV2t024817001.1	biological_process	GO:0006282	regulation of DNA repair	"Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]	OMA
NV2t024817001.1	biological_process	GO:0006366	transcription by RNA polymerase II	"The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382]	OMA
NV2t024817001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024817001.1	biological_process	GO:0031056	obsolete regulation of histone modification	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]	OMA
NV2t024817001.1	biological_process	GO:0031297	replication fork processing	"The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542]	OMA
NV2t024817001.1	biological_process	GO:0031440	regulation of mRNA 3'-end processing	"Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]	OMA
NV2t024817001.1	biological_process	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	"Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t024817001.1	biological_process	GO:0051099	positive regulation of binding	"Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]	OMA
NV2t024817001.1	biological_process	GO:0051147	regulation of muscle cell differentiation	"Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]	OMA
NV2t024817001.1	biological_process	GO:0051239	regulation of multicellular organismal process	"Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t024817001.1	biological_process	GO:0051851	modulation by host of symbiont process	"The process in which an host alters or subverts a process in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]	OMA
NV2t024817001.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	OMA
NV2t024817001.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t024817001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t024817001.1	biological_process	GO:0120187	positive regulation of protein localization to chromatin	"Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453]	OMA
NV2t024817001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t024817001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t024817001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t024817001.1	cellular_component	GO:0070691	P-TEFb complex	"A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T." [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067, Wikipedia:P-TEFb]	OMA
NV2t024817001.1	molecular_function	GO:0001223	transcription coactivator binding	"Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc]	OMA
NV2t024817001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t024817001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t024817001.1	molecular_function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	"Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]	OMA
NV2t024817001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024817001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024817001.1	molecular_function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	"Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II." [EC:2.7.11.23, GOC:mah, PMID:28248323]	OMA
NV2t024817001.1	molecular_function	GO:0097322	7SK snRNA binding	"Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533]	OMA
NV2t024817002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024817002.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t024818001.1	biological_process	GO:0006654	phosphatidic acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732]	PANTHER
NV2t024818001.1	biological_process	GO:0008654	phospholipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732]	OMA
NV2t024818001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024818001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024818001.1	molecular_function	GO:0016411	acylglycerol O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]	OMA
NV2t024818001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t024818001.1	molecular_function	GO:0042171	lysophosphatidic acid acyltransferase activity	"Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]	OMA
NV2t024822001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024822001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	PANTHER
NV2t024822001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t024823001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t024824001.1	cellular_component	GO:0031011	Ino80 complex	"A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820]	PANTHER
NV2t024825001.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	PANTHER
NV2t024825001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024826001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t024826001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024826002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t024826002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t024826002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024827001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t024827001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	PANTHER
NV2t024827001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024827002.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	PANTHER
NV2t024827002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024827003.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	PANTHER
NV2t024827003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024841001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024841001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t024841001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t024843001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t024843001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t024844001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t024844001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t024844001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t024845001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t024845001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024845002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t024845002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024845003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t024845003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024845004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t024845004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t024846001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024846001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t024847001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t024847001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024847001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t024847001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t024849001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t024849001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t024849001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024849001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t024849001.1	molecular_function	GO:0050479	glyceryl-ether monooxygenase activity	"Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN]	PANTHER
NV2t024850001.1	biological_process	GO:0018026	peptidyl-lysine monomethylation	"The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]	PANTHER
NV2t024850003.1	biological_process	GO:0018026	peptidyl-lysine monomethylation	"The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]	PANTHER
NV2t024851001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024851002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024851002.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	PANTHER
NV2t024852001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t024852001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024852001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024854001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t024854001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t024854001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t024854001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t024854001.1	molecular_function	GO:0047536	2-aminoadipate transaminase activity	"Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12601]	PANTHER
NV2t024855001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t024857001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t024857001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t024857001.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	OMA
NV2t024857002.1	molecular_function	GO:0008061	chitin binding	"Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732]	InterPro
NV2t024861001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024861001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024861001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024863001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t024867001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t024868001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024868001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t024868001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024868001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024868001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t024870001.1	biological_process	GO:0010608	post-transcriptional regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]	OMA
NV2t024870001.1	biological_process	GO:0035196	miRNA processing	"A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604]	OMA
NV2t024870001.1	biological_process	GO:0051640	organelle localization	"Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]	OMA
NV2t024870001.1	biological_process	GO:0051642	centrosome localization	"Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]	OMA
NV2t024870001.1	biological_process	GO:0051651	maintenance of location in cell	"Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]	OMA
NV2t024870001.1	cellular_component	GO:0000776	kinetochore	"A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]	OMA
NV2t024870001.1	cellular_component	GO:0031616	spindle pole centrosome	"A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]	OMA
NV2t024870001.1	cellular_component	GO:0072686	mitotic spindle	"A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]	OMA
NV2t024870001.1	molecular_function	GO:0035198	miRNA binding	"Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]	OMA
NV2t024871001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	InterPro
NV2t024871001.1	cellular_component	GO:0005852	eukaryotic translation initiation factor 3 complex	"A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]	OMA
NV2t024871001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024871001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t024871001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t024871001.1	molecular_function	GO:0003743	translation initiation factor activity	"Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]	OMA
NV2t024871001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t024872001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024872001.1	biological_process	GO:0071985	multivesicular body sorting pathway	"A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537]	InterPro
NV2t024872001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t024872001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t024873001.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t024873001.1	biological_process	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	"Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]	OMA
NV2t024873001.1	biological_process	GO:0046755	viral budding	"A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space." [ISBN:0781718325, VZ:1947]	PANTHER
NV2t024873001.1	cellular_component	GO:0000813	ESCRT I complex	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]	InterPro
NV2t024873001.1	cellular_component	GO:0000813	ESCRT I complex	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]	OMA
NV2t024873001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024873001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t024873001.1	cellular_component	GO:0005770	late endosome	"A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]	OMA
NV2t024873001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024873001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024873001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t024873002.1	biological_process	GO:0046755	viral budding	"A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space." [ISBN:0781718325, VZ:1947]	PANTHER
NV2t024873002.1	cellular_component	GO:0000813	ESCRT I complex	"An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]	InterPro
NV2t024874001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	InterPro
NV2t024874001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t024874001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t024874001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t024874001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	OMA
NV2t024874001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t024875001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t024875001.1	biological_process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	"Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators]	OMA
NV2t024875001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t024875001.1	biological_process	GO:0070536	protein K63-linked deubiquitination	"A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]	OMA
NV2t024875001.1	biological_process	GO:0071108	protein K48-linked deubiquitination	"A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]	OMA
NV2t024875001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024875001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t024875001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t024875001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t024875001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t024875001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	InterPro
NV2t024875001.1	molecular_function	GO:0004843	cysteine-type deubiquitinase activity	"An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated." [GOC:jh2, PMID:30783221]	OMA
NV2t024875001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024875001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t024876001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t024876001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024876001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024882001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t024882001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	OMA
NV2t024882001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t024885001.1	cellular_component	GO:0034974	Swi5-Swi2 complex	"A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching." [PMID:14663140]	PANTHER
NV2t024886001.1	biological_process	GO:0003341	cilium movement	"The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]	OMA
NV2t024886001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t024886001.1	biological_process	GO:0036158	outer dynein arm assembly	"The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]	OMA
NV2t024886001.1	cellular_component	GO:0035253	ciliary rootlet	"A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867]	OMA
NV2t024886001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	OMA
NV2t024886001.1	cellular_component	GO:0097542	ciliary tip	"Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]	OMA
NV2t024886001.1	cellular_component	GO:0097542	ciliary tip	"Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417]	PANTHER
NV2t024887001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t024887001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t024887001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t024887001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t024887001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t024887001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t024887001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024889001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t024889001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t024891001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024891001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024891001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024891001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024891001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024891001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t024891001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024891001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t024896001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t024896001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t024896001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t024896001.1	molecular_function	GO:0031406	carboxylic acid binding	"Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]	OMA
NV2t024896001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t024896001.1	molecular_function	GO:0048029	monosaccharide binding	"Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid]	OMA
NV2t024896001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t024896001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t024896002.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t024897001.1	biological_process	GO:0034402	obsolete recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex	"OBSOLETE. The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044]	PANTHER
NV2t024899001.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	InterPro
NV2t024901001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t024902001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t024902001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t024902001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t024902001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024902001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024902001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024902001.1	molecular_function	GO:0031386	protein tag activity	"A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, PMID:19028679, PMID:20054389, PMID:6305978]	OMA
NV2t024905001.1	molecular_function	GO:0000062	fatty-acyl-CoA binding	"Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]	InterPro
NV2t024905001.1	molecular_function	GO:0000062	fatty-acyl-CoA binding	"Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732]	PANTHER
NV2t024905001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024905001.1	molecular_function	GO:0008289	lipid binding	"Binding to a lipid." [GOC:ai]	OMA
NV2t024905001.1	molecular_function	GO:0032559	adenyl ribonucleotide binding	"Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]	OMA
NV2t024905001.1	molecular_function	GO:0033218	amide binding	"Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah]	OMA
NV2t024905001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t024905001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t024907001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t024907001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t024908001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	OMA
NV2t024908001.1	molecular_function	GO:0016836	hydro-lyase activity	"Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-]	PANTHER
NV2t024909001.1	biological_process	GO:0006260	DNA replication	"The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]	OMA
NV2t024909001.1	biological_process	GO:0006264	mitochondrial DNA replication	"The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai]	PANTHER
NV2t024909001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t024909001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t024910001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024910001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t024910001.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	PANTHER
NV2t024910001.1	biological_process	GO:0051304	chromosome separation	"The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243]	OMA
NV2t024910001.1	molecular_function	GO:0004712	protein serine/threonine/tyrosine kinase activity	"Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]	OMA
NV2t024910001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024910001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024910001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024910002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024910002.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	PANTHER
NV2t024910002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024910002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024910003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024910003.1	biological_process	GO:0034501	protein localization to kinetochore	"Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]	PANTHER
NV2t024910003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024910003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t024911001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t024911001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024911001.1	molecular_function	GO:0030695	GTPase regulator activity	"Binds to and modulates the activity of a GTPase." [GOC:mah]	InterPro
NV2t024911002.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t024911002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024911002.1	molecular_function	GO:0030695	GTPase regulator activity	"Binds to and modulates the activity of a GTPase." [GOC:mah]	InterPro
NV2t024911003.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t024911003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024911003.1	molecular_function	GO:0030695	GTPase regulator activity	"Binds to and modulates the activity of a GTPase." [GOC:mah]	InterPro
NV2t024911004.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t024911004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024911004.1	molecular_function	GO:0030695	GTPase regulator activity	"Binds to and modulates the activity of a GTPase." [GOC:mah]	InterPro
NV2t024911005.1	biological_process	GO:0000132	establishment of mitotic spindle orientation	"A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]	OMA
NV2t024911005.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	PANTHER
NV2t024911005.1	cellular_component	GO:0099738	cell cortex region	"The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos]	OMA
NV2t024911005.1	molecular_function	GO:0001965	G-protein alpha-subunit binding	"Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]	OMA
NV2t024911005.1	molecular_function	GO:0005092	GDP-dissociation inhibitor activity	"Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]	OMA
NV2t024911005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024911005.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t024911005.1	molecular_function	GO:0030695	GTPase regulator activity	"Binds to and modulates the activity of a GTPase." [GOC:mah]	InterPro
NV2t024913001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t024913001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t024913002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t024913002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t024914001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t024914001.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t024914001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t024914001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t024914001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024914001.1	molecular_function	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	"Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]	OMA
NV2t024914002.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t024914002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024914003.1	biological_process	GO:0035269	protein O-linked mannosylation	"The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]	PANTHER
NV2t024914003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024916001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024916001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024916001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024916001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024918001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t024918001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t024918001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	InterPro
NV2t024918001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t024921001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	InterPro
NV2t024921001.1	molecular_function	GO:0008146	sulfotransferase activity	"Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators]	OMA
NV2t024925001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024925001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024925001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t024927001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024927001.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024928001.1	molecular_function	GO:0008381	mechanosensitive monoatomic ion channel activity	"Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]	PANTHER
NV2t024929001.1	molecular_function	GO:0050998	nitric-oxide synthase binding	"Binding to nitric-oxide synthase." [GOC:ai]	PANTHER
NV2t024929002.1	molecular_function	GO:0050998	nitric-oxide synthase binding	"Binding to nitric-oxide synthase." [GOC:ai]	PANTHER
NV2t024931001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t024931001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t024931001.1	biological_process	GO:0030001	metal ion transport	"The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t024931001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024931001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024932001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t024932001.1	biological_process	GO:0015867	ATP transport	"The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t024932001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024932001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t024932001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t024932001.1	molecular_function	GO:0005347	ATP transmembrane transporter activity	"Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai]	OMA
NV2t024932001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024932001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024932002.1	biological_process	GO:0015867	ATP transport	"The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	PANTHER
NV2t024932002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024932002.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	InterPro
NV2t024932002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024933001.1	biological_process	GO:1901053	sarcosine catabolic process	"The chemical reactions and pathways resulting in the breakdown of sarcosine." [GOC:TermGenie, GOC:yaf, PMID:17951379]	OMA
NV2t024933001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t024933001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t024933001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024933001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024933001.1	molecular_function	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t024933002.1	biological_process	GO:1901053	sarcosine catabolic process	"The chemical reactions and pathways resulting in the breakdown of sarcosine." [GOC:TermGenie, GOC:yaf, PMID:17951379]	PANTHER
NV2t024933002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024933002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024933003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t024933003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024933003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t024934001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t024934001.1	biological_process	GO:0006970	response to osmotic stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]	OMA
NV2t024934001.1	biological_process	GO:0009792	embryo development ending in birth or egg hatching	"The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	OMA
NV2t024934001.1	biological_process	GO:0009886	post-embryonic animal morphogenesis	"The process, occurring after animal embryonic development, by which anatomical structures are generated and organized." [GOC:go_curators]	OMA
NV2t024934001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t024934001.1	molecular_function	GO:0004879	nuclear receptor activity	"A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]	PANTHER
NV2t024934001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t024934001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t024934001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t024934001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t024935001.1	biological_process	GO:0031623	receptor internalization	"A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732]	OMA
NV2t024935001.1	biological_process	GO:0048488	synaptic vesicle endocytosis	"A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]	OMA
NV2t024935001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024935001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t024935001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024935001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t024935001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t024935001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t024935001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t024935001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t024935001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t024935002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t024935002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t024937001.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t024937002.1	molecular_function	GO:0070679	inositol 1,4,5 trisphosphate binding	"Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]	PANTHER
NV2t024939001.1	biological_process	GO:0002684	positive regulation of immune system process	"Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]	OMA
NV2t024939001.1	biological_process	GO:0006911	phagocytosis, engulfment	"The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149]	OMA
NV2t024939001.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t024939001.1	biological_process	GO:0008284	positive regulation of cell population proliferation	"Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t024939001.1	biological_process	GO:0022409	positive regulation of cell-cell adhesion	"Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]	OMA
NV2t024939001.1	biological_process	GO:0030041	actin filament polymerization	"Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t024939001.1	biological_process	GO:0030335	positive regulation of cell migration	"Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]	OMA
NV2t024939001.1	biological_process	GO:0045087	innate immune response	"Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]	OMA
NV2t024939001.1	biological_process	GO:0050921	positive regulation of chemotaxis	"Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]	OMA
NV2t024939001.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	OMA
NV2t024939001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t024939001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t024939001.1	biological_process	GO:0097178	ruffle assembly	"The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42." [GOC:yaf, http:en.wikipedia.org/wiki/Membrane_ruffling, PMID:12556481]	PANTHER
NV2t024939001.1	biological_process	GO:0120031	plasma membrane bounded cell projection assembly	"Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t024939001.1	biological_process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	"Any signaling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]	OMA
NV2t024939001.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t024939001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024939001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024939001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t024939001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t024939001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t024939001.1	cellular_component	GO:0031256	leading edge membrane	"The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]	OMA
NV2t024939001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024939001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024939001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t024941001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024941001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t024941001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t024941002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t024941002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t024941002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t024945001.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t024945001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024945002.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t024945002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024945003.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t024945003.1	cellular_component	GO:0046540	U4/U6 x U5 tri-snRNP complex	"A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543]	PANTHER
NV2t024945003.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t024945003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024945003.1	molecular_function	GO:0017070	U6 snRNA binding	"Binding to a U6 small nuclear RNA (U6 snRNA)." [GOC:mah]	OMA
NV2t024945003.1	molecular_function	GO:0030621	U4 snRNA binding	"Binding to a U4 small nuclear RNA (U4 snRNA)." [GOC:jl]	OMA
NV2t024946001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t024946001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t024946001.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t024946001.1	biological_process	GO:0051128	regulation of cellular component organization	"Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]	OMA
NV2t024946001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024946001.1	cellular_component	GO:0031982	vesicle	"Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles]	OMA
NV2t024946001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t024946001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024946001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t024947001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t024947001.1	biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	PANTHER
NV2t024947002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t024947002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	OMA
NV2t024947002.1	biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	OMA
NV2t024947002.1	biological_process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	"Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]	PANTHER
NV2t024947002.1	molecular_function	GO:0001784	phosphotyrosine residue binding	"Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584]	OMA
NV2t024947002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t024948001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024949001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024949001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t024949001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t024949001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	PANTHER
NV2t024949001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t024950001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024951001.1	molecular_function	GO:0005488	binding	"The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]	OMA
NV2t024951001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024951001.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t024951002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024951002.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t024951003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t024951003.1	molecular_function	GO:0051010	microtubule plus-end binding	"Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]	PANTHER
NV2t024955001.1	biological_process	GO:0006536	glutamate metabolic process	"The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]	OMA
NV2t024955001.1	biological_process	GO:0006760	folic acid-containing compound metabolic process	"The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah]	OMA
NV2t024955001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t024955001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t024955001.1	biological_process	GO:0009396	folic acid-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]	InterPro
NV2t024955001.1	biological_process	GO:0042398	cellular modified amino acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t024955001.1	biological_process	GO:0042559	pteridine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]	OMA
NV2t024955001.1	biological_process	GO:0046901	tetrahydrofolylpolyglutamate biosynthetic process	"The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]	PANTHER
NV2t024955001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t024955001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024955001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024955001.1	molecular_function	GO:0016881	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	InterPro
NV2t024955001.1	molecular_function	GO:0016881	acid-amino acid ligase activity	"Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]	OMA
NV2t024959001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024959001.1	molecular_function	GO:0008175	tRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah]	OMA
NV2t024963001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t024963001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t024965001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t024965001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t024965001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t024965001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	PANTHER
NV2t024965001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024968001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t024968001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	PANTHER
NV2t024968001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t024972001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t024972001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	OMA
NV2t024974001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t024974001.1	biological_process	GO:0035522	obsolete monoubiquitinated histone H2A deubiquitination	"OBSOLETE. The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459]	OMA
NV2t024974001.1	cellular_component	GO:0000124	SAGA complex	"A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486]	OMA
NV2t024974001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t024974001.1	cellular_component	GO:0070461	SAGA-type complex	"A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012]	InterPro
NV2t024974001.1	molecular_function	GO:0003713	transcription coactivator activity	"A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t024977001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024977001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024977002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024978001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024978001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t024978001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t024978001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t024978002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t024978002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t024979001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024979002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024979003.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t024980001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t024981001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	OMA
NV2t024981001.1	biological_process	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	OMA
NV2t024981001.1	biological_process	GO:0030317	flagellated sperm motility	"The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031]	OMA
NV2t024981001.1	biological_process	GO:0030518	intracellular steroid hormone receptor signaling pathway	"The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor." [GOC:mah, GOC:signaling]	OMA
NV2t024981001.1	biological_process	GO:0031397	negative regulation of protein ubiquitination	"Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah]	OMA
NV2t024981001.1	biological_process	GO:0042026	protein refolding	"The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]	OMA
NV2t024981001.1	biological_process	GO:0043065	positive regulation of apoptotic process	"Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t024981001.1	biological_process	GO:0043508	negative regulation of JUN kinase activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl]	OMA
NV2t024981001.1	biological_process	GO:0051223	regulation of protein transport	"Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t024981001.1	biological_process	GO:0070585	protein localization to mitochondrion	"A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd]	OMA
NV2t024981001.1	biological_process	GO:1904950	negative regulation of establishment of protein localization	"Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445]	OMA
NV2t024981001.1	biological_process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	"Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis]	OMA
NV2t024981001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t024981001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t024981001.1	cellular_component	GO:0043232	intracellular non-membrane-bounded organelle	"Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]	OMA
NV2t024981001.1	molecular_function	GO:0001664	G protein-coupled receptor binding	"Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph]	OMA
NV2t024981001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t024981001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t024981001.1	molecular_function	GO:0019904	protein domain specific binding	"Binding to a specific domain of a protein." [GOC:go_curators]	OMA
NV2t024981001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t024981001.1	molecular_function	GO:0030957	Tat protein binding	"Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689]	OMA
NV2t024981001.1	molecular_function	GO:0031625	ubiquitin protein ligase binding	"Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]	OMA
NV2t024981001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	InterPro
NV2t024981001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t024981001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t024981001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t024981001.1	molecular_function	GO:0070325	lipoprotein particle receptor binding	"Binding to a lipoprotein particle receptor." [GOC:BHF, GOC:rl]	OMA
NV2t024983001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024983001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024983001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024983001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024984003.1	biological_process	GO:0050808	synapse organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]	PANTHER
NV2t024985001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t024985001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t024985001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t024985001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t024985001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	OMA
NV2t024989001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t024989001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t024989001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t024989001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t024998001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025004001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025004001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t025004001.1	cellular_component	GO:0005856	cytoskeleton	"A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, PMID:16959967, PMID:27419875]	OMA
NV2t025004001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025004001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025004001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025004001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t025004001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t025004001.1	molecular_function	GO:0070063	RNA polymerase binding	"Binding to an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH]	OMA
NV2t025005001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025005001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025005001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025005002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025005002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025006001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025006001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025006001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025006002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025006002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025006003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025006003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025007001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t025007001.1	biological_process	GO:1902652	secondary alcohol metabolic process	"The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]	OMA
NV2t025007001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025007001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025007001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t025007001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t025007001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t025007002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025007002.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t025007003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025007003.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t025009001.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t025009001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025009002.1	biological_process	GO:0045047	protein targeting to ER	"The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]	PANTHER
NV2t025009002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025010001.1	biological_process	GO:0015914	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	InterPro
NV2t025010001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025010001.1	molecular_function	GO:0008525	phosphatidylcholine transporter activity	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]	OMA
NV2t025010001.1	molecular_function	GO:0008526	phosphatidylinositol transfer activity	"Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t025010001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t025010001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t025010001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t025010001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t025011001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t025011001.1	biological_process	GO:0015914	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	InterPro
NV2t025011001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t025011001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t025011001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t025011001.1	molecular_function	GO:0008525	phosphatidylcholine transporter activity	"Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732]	OMA
NV2t025011001.1	molecular_function	GO:0008526	phosphatidylinositol transfer activity	"Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t025011001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	OMA
NV2t025011001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t025011001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t025011001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t025011001.1	molecular_function	GO:0120016	sphingolipid transfer activity	"Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]	OMA
NV2t025011002.1	biological_process	GO:0015914	phospholipid transport	"The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]	InterPro
NV2t025011002.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	PANTHER
NV2t025012001.1	biological_process	GO:0009987	cellular process	"Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]	OMA
NV2t025012001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t025012001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t025012001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t025012001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t025012001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025012001.1	cellular_component	GO:0030139	endocytic vesicle	"A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]	OMA
NV2t025012001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025012001.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t025012001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025012001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025012001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	OMA
NV2t025012001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t025012002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t025012003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t025014001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025015001.1	biological_process	GO:0001845	phagolysosome assembly	"The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149]	OMA
NV2t025015001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t025015001.1	biological_process	GO:0006892	post-Golgi vesicle-mediated transport	"The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]	OMA
NV2t025015001.1	biological_process	GO:0008543	fibroblast growth factor receptor signaling pathway	"The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]	OMA
NV2t025015001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	PANTHER
NV2t025015001.1	biological_process	GO:0016482	cytosolic transport	"The directed movement of substances or organelles within the cytosol." [GOC:ai]	OMA
NV2t025015001.1	biological_process	GO:0032456	endocytic recycling	"The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491]	OMA
NV2t025015001.1	biological_process	GO:0042742	defense response to bacterium	"Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]	OMA
NV2t025015001.1	biological_process	GO:0043277	apoptotic cell clearance	"The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684]	OMA
NV2t025015001.1	biological_process	GO:0045995	regulation of embryonic development	"Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]	OMA
NV2t025015001.1	biological_process	GO:0090382	phagosome maturation	"A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb]	InterPro
NV2t025015001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t025015001.1	cellular_component	GO:0005802	trans-Golgi network	"The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]	OMA
NV2t025015001.1	cellular_component	GO:0045335	phagocytic vesicle	"A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t025015001.1	cellular_component	GO:0055037	recycling endosome	"An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044]	OMA
NV2t025015001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t025015001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t025015001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t025016001.1	biological_process	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	"The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]	OMA
NV2t025016001.1	biological_process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	"Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	PANTHER
NV2t025016001.1	cellular_component	GO:0005758	mitochondrial intermembrane space	"The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]	OMA
NV2t025016001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t025016001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t025016001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t025021001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025021002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025025002.1	molecular_function	GO:0043035	chromatin insulator sequence binding	"Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]	PANTHER
NV2t025025003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025025003.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025025003.1	molecular_function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859]	OMA
NV2t025025003.1	molecular_function	GO:0043035	chromatin insulator sequence binding	"Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]	PANTHER
NV2t025027001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t025027001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025028001.1	biological_process	GO:0043419	urea catabolic process	"The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl]	InterPro
NV2t025028001.1	molecular_function	GO:0016151	nickel cation binding	"Binding to a nickel (Ni) cation." [GOC:ai]	InterPro
NV2t025028001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025028001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t025028002.1	biological_process	GO:0043419	urea catabolic process	"The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl]	InterPro
NV2t025028002.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t025028002.1	biological_process	GO:0044282	small molecule catabolic process	"The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]	OMA
NV2t025028002.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t025028002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025028002.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t025028002.1	molecular_function	GO:0009039	urease activity	"Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5, RHEA:20557]	InterPro
NV2t025028002.1	molecular_function	GO:0016151	nickel cation binding	"Binding to a nickel (Ni) cation." [GOC:ai]	InterPro
NV2t025028002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025028002.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t025028002.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t025028002.1	molecular_function	GO:0046914	transition metal ion binding	"Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]	OMA
NV2t025029001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t025029001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t025029001.1	molecular_function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]	OMA
NV2t025029001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t025029001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t025029001.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t025029002.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	InterPro
NV2t025029002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t025029002.1	molecular_function	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity	"Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced NADPH--hemoprotein reductase = acetate + androst-4-ene-3,17-dione + 2 H+ + H2O + oxidized NADPH--hemoprotein reductase." [MetaCyc:4.1.2.30-RXN, RHEA:14753]	PANTHER
NV2t025031001.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	InterPro
NV2t025031001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t025031002.1	biological_process	GO:0006165	obsolete nucleoside diphosphate phosphorylation	"OBSOLETE. The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]	OMA
NV2t025031002.1	biological_process	GO:0009142	nucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t025031002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025031002.1	cellular_component	GO:0043229	intracellular organelle	"Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t025031002.1	cellular_component	GO:0097729	9+2 motile cilium	"A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931]	OMA
NV2t025031002.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	InterPro
NV2t025031002.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	OMA
NV2t025031002.1	molecular_function	GO:0004127	cytidylate kinase activity	"Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14]	OMA
NV2t025031002.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t025031002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025031002.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t025031002.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t025033001.1	biological_process	GO:0006974	DNA damage response	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]	OMA
NV2t025033001.1	biological_process	GO:0018142	obsolete protein-DNA covalent cross-linking	"OBSOLETE. The formation of a covalent cross-link between DNA and a protein." [GOC:ma]	InterPro
NV2t025033001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t025033001.1	molecular_function	GO:0003697	single-stranded DNA binding	"Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]	OMA
NV2t025033002.1	biological_process	GO:0018142	obsolete protein-DNA covalent cross-linking	"OBSOLETE. The formation of a covalent cross-link between DNA and a protein." [GOC:ma]	InterPro
NV2t025033003.1	biological_process	GO:0018142	obsolete protein-DNA covalent cross-linking	"OBSOLETE. The formation of a covalent cross-link between DNA and a protein." [GOC:ma]	InterPro
NV2t025034001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025034001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t025034002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025034002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t025034003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025034003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t025034003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025034003.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t025034003.1	molecular_function	GO:0004697	diacylglycerol-dependent serine/threonine kinase activity	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]	OMA
NV2t025034003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025034003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025034003.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	InterPro
NV2t025034004.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025034004.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	PANTHER
NV2t025034004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025035001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025035001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025037001.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t025037001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025037002.1	biological_process	GO:0071277	cellular response to calcium ion	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]	PANTHER
NV2t025037002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025039001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025039001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025039001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t025042001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025044001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	PANTHER
NV2t025045001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025045001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025045001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025048001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025048001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025048001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025048001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025052001.1	biological_process	GO:0006772	thiamine metabolic process	"The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025052001.1	biological_process	GO:0006796	phosphate-containing compound metabolic process	"The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]	OMA
NV2t025052001.1	biological_process	GO:0009229	thiamine diphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0140512713]	InterPro
NV2t025052001.1	biological_process	GO:0009229	thiamine diphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0140512713]	PANTHER
NV2t025052001.1	biological_process	GO:0019438	obsolete aromatic compound biosynthetic process	"OBSOLETE. The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]	OMA
NV2t025052001.1	biological_process	GO:0034308	primary alcohol metabolic process	"The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]	OMA
NV2t025052001.1	biological_process	GO:0042364	water-soluble vitamin biosynthetic process	"The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl]	OMA
NV2t025052001.1	biological_process	GO:0044272	sulfur compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]	OMA
NV2t025052001.1	biological_process	GO:0072528	pyrimidine-containing compound biosynthetic process	"The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah]	OMA
NV2t025052001.1	biological_process	GO:0090407	organophosphate biosynthetic process	"The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg]	OMA
NV2t025052001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025052001.1	molecular_function	GO:0016772	transferase activity, transferring phosphorus-containing groups	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t025052001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t025052001.1	molecular_function	GO:0030975	thiamine binding	"Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg]	InterPro
NV2t025052001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t025052001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t025052001.1	molecular_function	GO:0043178	alcohol binding	"Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]	OMA
NV2t025052001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t025053001.1	biological_process	GO:0035434	copper ion transmembrane transport	"The directed movement of copper cation across a membrane." [GOC:vw]	InterPro
NV2t025054001.1	biological_process	GO:0051298	centrosome duplication	"The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]	PANTHER
NV2t025056001.1	biological_process	GO:0006351	DNA-templated transcription	"The synthesis of an RNA transcript from a DNA template." [GOC:jl, GOC:txnOH]	InterPro
NV2t025056001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025057001.1	biological_process	GO:0031145	anaphase-promoting complex-dependent catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442]	OMA
NV2t025057001.1	biological_process	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	"Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators]	OMA
NV2t025057001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	OMA
NV2t025057001.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t025057001.1	cellular_component	GO:0005680	anaphase-promoting complex	"A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]	OMA
NV2t025057001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025057002.1	biological_process	GO:0070979	protein K11-linked ubiquitination	"A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135]	PANTHER
NV2t025057002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025058001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025058001.1	molecular_function	GO:0070034	telomerase RNA binding	"Binding to the telomerase RNA template." [GOC:krc, PMID:16884717]	PANTHER
NV2t025060001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025060001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	InterPro
NV2t025060001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t025061001.1	biological_process	GO:0006081	cellular aldehyde metabolic process	"The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t025061001.1	biological_process	GO:0051289	protein homotetramerization	"The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]	OMA
NV2t025061001.1	molecular_function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	"Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]	OMA
NV2t025061001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025061001.1	molecular_function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]	InterPro
NV2t025061001.1	molecular_function	GO:0047105	4-trimethylammoniobutyraldehyde dehydrogenase activity	"Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN]	PANTHER
NV2t025062001.1	biological_process	GO:0006878	intracellular copper ion homeostasis	"A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell." [GOC:ai, GOC:mah]	OMA
NV2t025062001.1	biological_process	GO:0035434	copper ion transmembrane transport	"The directed movement of copper cation across a membrane." [GOC:vw]	InterPro
NV2t025062001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025062001.1	molecular_function	GO:0005375	copper ion transmembrane transporter activity	"Enables the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t025063001.1	biological_process	GO:0035434	copper ion transmembrane transport	"The directed movement of copper cation across a membrane." [GOC:vw]	InterPro
NV2t025063001.1	molecular_function	GO:0005375	copper ion transmembrane transporter activity	"Enables the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t025064001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025068001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t025070001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025070001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025072001.1	biological_process	GO:0048168	regulation of neuronal synaptic plasticity	"A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, PMID:11891290]	OMA
NV2t025072001.1	biological_process	GO:2001222	regulation of neuron migration	"Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol]	InterPro
NV2t025072001.1	biological_process	GO:2001222	regulation of neuron migration	"Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol]	OMA
NV2t025072001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025073001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t025073001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025073001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025073001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025073002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t025073002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025075001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025075002.1	biological_process	GO:0030974	thiamine pyrophosphate transmembrane transport	"The process in which thiamine pyrophosphate is transported across a membrane." [GOC:mlg]	OMA
NV2t025075002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025075002.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t025075002.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t025075002.1	molecular_function	GO:0015234	thiamine transmembrane transporter activity	"Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t025075003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025075003.1	cellular_component	GO:0031305	obsolete integral component of mitochondrial inner membrane	"OBSOLETE. The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]	PANTHER
NV2t025076001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t025076002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t025076002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025076002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t025078001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	InterPro
NV2t025078001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t025089001.1	biological_process	GO:0006897	endocytosis	"A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363, Wikipedia:Endocytosis]	OMA
NV2t025090001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025090001.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t025090002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025090002.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t025090003.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025090003.1	biological_process	GO:0090141	positive regulation of mitochondrial fission	"Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t025092001.1	biological_process	GO:0003143	embryonic heart tube morphogenesis	"The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]	OMA
NV2t025092001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025092001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025092001.1	biological_process	GO:0007368	determination of left/right symmetry	"The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid]	OMA
NV2t025092001.1	biological_process	GO:0007492	endoderm development	"The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb]	OMA
NV2t025092001.1	biological_process	GO:0007498	mesoderm development	"The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]	OMA
NV2t025092001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t025092001.1	biological_process	GO:0035265	organ growth	"The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t025092001.1	biological_process	GO:0050793	regulation of developmental process	"Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]	OMA
NV2t025092001.1	biological_process	GO:0055007	cardiac muscle cell differentiation	"The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart]	OMA
NV2t025092001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025092001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025092001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025092001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025096001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025096001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025096001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t025097001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t025097001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t025097001.1	biological_process	GO:0033108	mitochondrial respiratory chain complex assembly	"The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]	OMA
NV2t025097001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t025097001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t025097001.1	molecular_function	GO:0043022	ribosome binding	"Binding to a ribosome." [GOC:go_curators]	OMA
NV2t025097002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t025099001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025099001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025100001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025100001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025100001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t025101001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025101001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025101001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t025101001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t025103001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	InterPro
NV2t025103001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t025103001.1	biological_process	GO:0016311	dephosphorylation	"The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]	InterPro
NV2t025103001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t025103001.1	molecular_function	GO:0004725	protein tyrosine phosphatase activity	"Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]	OMA
NV2t025103001.1	molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	"Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah]	OMA
NV2t025103001.1	molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	"Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]	InterPro
NV2t025103001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t025103001.1	molecular_function	GO:0033549	MAP kinase phosphatase activity	"Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316]	OMA
NV2t025108001.1	biological_process	GO:0000086	G2/M transition of mitotic cell cycle	"The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle]	OMA
NV2t025108001.1	biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]	OMA
NV2t025108001.1	biological_process	GO:0043153	entrainment of circadian clock by photoperiod	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]	OMA
NV2t025108001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t025108001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025108001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025108001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	InterPro
NV2t025108001.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	OMA
NV2t025108001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025108002.1	cellular_component	GO:0019005	SCF ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]	InterPro
NV2t025108002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025109001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t025109001.1	biological_process	GO:0045454	cell redox homeostasis	"Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t025109001.1	biological_process	GO:0098869	cellular oxidant detoxification	"Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide." [GOC:dos, GOC:vw]	InterPro
NV2t025109001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025109001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025109001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025109001.1	molecular_function	GO:0051920	peroxiredoxin activity	"Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]	InterPro
NV2t025109001.1	molecular_function	GO:0051920	peroxiredoxin activity	"Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH." [RHEA:10008]	OMA
NV2t025110001.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025110001.1	biological_process	GO:0009056	catabolic process	"The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]	OMA
NV2t025110001.1	biological_process	GO:0043603	amide metabolic process	"The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators]	OMA
NV2t025110001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025110001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	InterPro
NV2t025110001.1	molecular_function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	"Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]	OMA
NV2t025110002.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025110003.1	biological_process	GO:0006807	obsolete nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025112001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t025112001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025112001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025112001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025112001.1	molecular_function	GO:0008559	ABC-type xenobiotic transporter activity	"Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2]	OMA
NV2t025112001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025112001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t025112002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t025112002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025112002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025112002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t025113001.1	biological_process	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	InterPro
NV2t025114001.1	biological_process	GO:0034453	microtubule anchoring	"Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah]	InterPro
NV2t025114001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t025114001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025115001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	OMA
NV2t025115001.1	biological_process	GO:0034599	cellular response to oxidative stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]	PANTHER
NV2t025115001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025115001.1	molecular_function	GO:0032542	sulfiredoxin activity	"Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934]	OMA
NV2t025117001.1	biological_process	GO:0007283	spermatogenesis	"The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]	InterPro
NV2t025117001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t025117001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025117001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025117001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025117001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t025117001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t025118001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025118001.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t025118001.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t025118002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025118002.1	biological_process	GO:0070588	calcium ion transmembrane transport	"A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah]	InterPro
NV2t025118002.1	biological_process	GO:0098703	calcium ion import across plasma membrane	"The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos]	PANTHER
NV2t025118002.1	cellular_component	GO:0005891	voltage-gated calcium channel complex	"A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]	OMA
NV2t025118002.1	molecular_function	GO:0005245	voltage-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]	OMA
NV2t025121001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t025121001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t025123001.1	cellular_component	GO:0005765	lysosomal membrane	"The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]	OMA
NV2t025123001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t025125001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025125001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025129001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	PANTHER
NV2t025130001.1	cellular_component	GO:0030173	obsolete integral component of Golgi membrane	"OBSOLETE. The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]	PANTHER
NV2t025130001.1	molecular_function	GO:0015035	protein-disulfide reductase activity	"Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385]	OMA
NV2t025130001.1	molecular_function	GO:0016972	thiol oxidase activity	"Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357]	InterPro
NV2t025130001.1	molecular_function	GO:0016972	thiol oxidase activity	"Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357]	OMA
NV2t025132001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025132002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025132003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025133001.1	cellular_component	GO:0005929	cilium	"A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]	OMA
NV2t025133001.1	cellular_component	GO:0036064	ciliary basal body	"A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]	PANTHER
NV2t025134001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025135001.1	biological_process	GO:0008283	cell population proliferation	"The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]	OMA
NV2t025135001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025135001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025135001.1	cellular_component	GO:0030496	midbody	"A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]	OMA
NV2t025135001.1	cellular_component	GO:0032154	cleavage furrow	"The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409]	OMA
NV2t025135001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025136001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	InterPro
NV2t025136001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025137001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t025137001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t025137001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t025137001.1	biological_process	GO:0044743	protein transmembrane import into intracellular organelle	"The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl]	OMA
NV2t025137001.1	biological_process	GO:0065002	intracellular protein transmembrane transport	"The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete]	OMA
NV2t025137001.1	biological_process	GO:1990542	mitochondrial transmembrane transport	"The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]	OMA
NV2t025137001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t025137001.1	cellular_component	GO:0098800	inner mitochondrial membrane protein complex	"Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos]	OMA
NV2t025137001.1	molecular_function	GO:0030554	adenyl nucleotide binding	"Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732]	OMA
NV2t025137001.1	molecular_function	GO:0042803	protein homodimerization activity	"Binding to an identical protein to form a homodimer." [GOC:jl]	OMA
NV2t025137001.1	molecular_function	GO:0051082	unfolded protein binding	"Binding to an unfolded protein." [GOC:ai]	OMA
NV2t025137001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	InterPro
NV2t025137001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t025137001.1	molecular_function	GO:0060590	ATPase regulator activity	"Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]	OMA
NV2t025138001.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t025138001.1	biological_process	GO:0008089	anterograde axonal transport	"The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]	OMA
NV2t025138001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t025138001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	OMA
NV2t025138001.1	biological_process	GO:0032501	multicellular organismal process	"Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]	OMA
NV2t025138001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	OMA
NV2t025138001.1	cellular_component	GO:0005871	kinesin complex	"Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]	OMA
NV2t025138001.1	cellular_component	GO:0005874	microtubule	"Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]	OMA
NV2t025138001.1	cellular_component	GO:0030424	axon	"The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]	OMA
NV2t025138001.1	cellular_component	GO:0030425	dendrite	"A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]	OMA
NV2t025138001.1	cellular_component	GO:0031410	cytoplasmic vesicle	"A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles]	OMA
NV2t025138001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025138001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025138001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t025138001.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	OMA
NV2t025138001.1	molecular_function	GO:0008574	plus-end-directed microtubule motor activity	"A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis." [GOC:vw, PMID:32842864]	OMA
NV2t025138001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t025138002.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t025138002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025138002.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t025138003.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t025138003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025138003.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t025138004.1	biological_process	GO:0007018	microtubule-based movement	"A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194]	InterPro
NV2t025138004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025138004.1	molecular_function	GO:0008017	microtubule binding	"Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc]	InterPro
NV2t025139001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025140001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t025140001.1	molecular_function	GO:0008080	N-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]	PANTHER
NV2t025140001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t025141001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025141001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025141001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025141001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025143001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t025144001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t025144001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t025144001.1	cellular_component	GO:0005681	spliceosomal complex	"Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]	PANTHER
NV2t025144001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t025144001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t025146001.1	biological_process	GO:0006098	pentose-phosphate shunt	"The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY]	OMA
NV2t025146001.1	biological_process	GO:0046390	ribose phosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]	OMA
NV2t025146001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t025146001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t025146001.1	molecular_function	GO:0016740	transferase activity	"Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]	OMA
NV2t025146001.1	molecular_function	GO:0019842	vitamin binding	"Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]	OMA
NV2t025146001.1	molecular_function	GO:0030976	thiamine pyrophosphate binding	"Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg]	PANTHER
NV2t025146001.1	molecular_function	GO:0043168	anion binding	"Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl]	OMA
NV2t025146001.1	molecular_function	GO:0043169	cation binding	"Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl]	OMA
NV2t025146001.1	molecular_function	GO:0050997	quaternary ammonium group binding	"Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]	OMA
NV2t025146001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t025146001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t025146001.1	molecular_function	GO:1901681	sulfur compound binding	"Binding to a sulfur compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t025148001.1	biological_process	GO:0006898	receptor-mediated endocytosis	"An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363]	OMA
NV2t025148001.1	biological_process	GO:0007416	synapse assembly	"The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah]	OMA
NV2t025148001.1	biological_process	GO:0048812	neuron projection morphogenesis	"The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]	OMA
NV2t025148001.1	biological_process	GO:0120031	plasma membrane bounded cell projection assembly	"Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t025148001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t025148001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t025148001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t025150001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t025150001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t025150001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t025150002.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t025150002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t025160001.1	cellular_component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	"A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]	InterPro
NV2t025160001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025162001.1	biological_process	GO:0045216	cell-cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t025162002.1	biological_process	GO:0045216	cell-cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t025162003.1	biological_process	GO:0045216	cell-cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t025163001.1	biological_process	GO:0000027	ribosomal large subunit assembly	"The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl, PMID:30467428]	OMA
NV2t025163001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t025163001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t025163001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t025163001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t025163001.1	molecular_function	GO:0008097	5S rRNA binding	"Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]	InterPro
NV2t025163001.1	molecular_function	GO:0008097	5S rRNA binding	"Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]	OMA
NV2t025164001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025164001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025164001.1	molecular_function	GO:0042277	peptide binding	"Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl]	PANTHER
NV2t025166001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025166001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t025168001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t025168001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t025168001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025168001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t025168001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025168001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025168001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t025169001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t025169001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025169001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025169001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025170001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t025171001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	OMA
NV2t025171001.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t025171001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t025171001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t025171001.1	molecular_function	GO:0005102	signaling receptor binding	"Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t025171001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025171002.1	biological_process	GO:0048856	anatomical structure development	"The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021]	PANTHER
NV2t025171002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025180001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t025180001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t025180001.1	biological_process	GO:0022618	protein-RNA complex assembly	"The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]	OMA
NV2t025180001.1	biological_process	GO:0042255	ribosome assembly	"The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma, PMID:30467428]	OMA
NV2t025180001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t025180001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	InterPro
NV2t025180001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	OMA
NV2t025180001.1	cellular_component	GO:0022627	cytosolic small ribosomal subunit	"The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t025180001.1	molecular_function	GO:0003729	mRNA binding	"Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234]	OMA
NV2t025180001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t025180001.1	molecular_function	GO:0019843	rRNA binding	"Binding to a ribosomal RNA." [GOC:jl]	OMA
NV2t025181001.1	biological_process	GO:0001505	obsolete regulation of neurotransmitter levels	"OBSOLETE. Any process that modulates levels of neurotransmitter." [GOC:jl]	OMA
NV2t025181001.1	biological_process	GO:0001817	regulation of cytokine production	"Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]	OMA
NV2t025181001.1	biological_process	GO:0001934	positive regulation of protein phosphorylation	"Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]	OMA
NV2t025181001.1	biological_process	GO:0002090	regulation of receptor internalization	"Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]	OMA
NV2t025181001.1	biological_process	GO:0007009	plasma membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t025181001.1	biological_process	GO:0010628	positive regulation of gene expression	"Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t025181001.1	biological_process	GO:0022617	extracellular matrix disassembly	"A process that results in the breakdown of the extracellular matrix." [GOC:jid]	OMA
NV2t025181001.1	biological_process	GO:0032092	positive regulation of protein binding	"Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]	OMA
NV2t025181001.1	biological_process	GO:0032226	positive regulation of synaptic transmission, dopaminergic	"Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]	OMA
NV2t025181001.1	biological_process	GO:0033227	dsRNA transport	"The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t025181001.1	biological_process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	"Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]	OMA
NV2t025181001.1	biological_process	GO:0034976	response to endoplasmic reticulum stress	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah]	OMA
NV2t025181001.1	biological_process	GO:0035556	intracellular signal transduction	"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]	OMA
NV2t025181001.1	biological_process	GO:0043330	response to exogenous dsRNA	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators]	OMA
NV2t025181001.1	biological_process	GO:0045807	positive regulation of endocytosis	"Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]	OMA
NV2t025181001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t025181001.1	biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	"Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]	OMA
NV2t025181001.1	biological_process	GO:0051094	positive regulation of developmental process	"Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]	OMA
NV2t025181001.1	biological_process	GO:0051240	positive regulation of multicellular organismal process	"Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]	OMA
NV2t025181001.1	biological_process	GO:0051588	regulation of neurotransmitter transport	"Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]	OMA
NV2t025181001.1	biological_process	GO:0062208	positive regulation of pattern recognition receptor signaling pathway	"Any process that decreases the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168]	OMA
NV2t025181001.1	biological_process	GO:0071407	cellular response to organic cyclic compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah]	OMA
NV2t025181001.1	biological_process	GO:0071709	membrane assembly	"The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah]	OMA
NV2t025181001.1	biological_process	GO:0072659	protein localization to plasma membrane	"A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah]	OMA
NV2t025181001.1	biological_process	GO:1901699	cellular response to nitrogen compound	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie]	OMA
NV2t025181001.1	biological_process	GO:1901739	regulation of myoblast fusion	"Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645]	OMA
NV2t025181001.1	biological_process	GO:1901861	regulation of muscle tissue development	"Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719]	OMA
NV2t025181001.1	biological_process	GO:1901890	positive regulation of cell junction assembly	"Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t025181001.1	biological_process	GO:2000047	regulation of cell-cell adhesion mediated by cadherin	"Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]	OMA
NV2t025181001.1	biological_process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	"Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]	PANTHER
NV2t025181001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t025181001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t025181001.1	cellular_component	GO:0005912	adherens junction	"A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264]	OMA
NV2t025181001.1	cellular_component	GO:0016323	basolateral plasma membrane	"The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]	OMA
NV2t025181001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t025181001.1	cellular_component	GO:0030864	cortical actin cytoskeleton	"The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]	OMA
NV2t025181001.1	cellular_component	GO:0031254	cell trailing edge	"The area of a motile cell opposite to the direction of movement." [GOC:pg]	OMA
NV2t025181001.1	cellular_component	GO:0044291	cell-cell contact zone	"Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018]	OMA
NV2t025181001.1	cellular_component	GO:0045121	membrane raft	"Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]	OMA
NV2t025181001.1	cellular_component	GO:0098691	dopaminergic synapse	"A synapse that uses dopamine as a neurotransmitter." [GOC:dos]	OMA
NV2t025181001.1	cellular_component	GO:0098797	plasma membrane protein complex	"Any protein complex that is part of the plasma membrane." [GOC:dos]	OMA
NV2t025181001.1	molecular_function	GO:0002020	protease binding	"Binding to a protease or a peptidase." [GOC:hjd]	OMA
NV2t025181002.1	biological_process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	"Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]	PANTHER
NV2t025181003.1	biological_process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	"Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]	PANTHER
NV2t025181004.1	biological_process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	"Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]	PANTHER
NV2t025181005.1	biological_process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	"Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]	PANTHER
NV2t025182001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	InterPro
NV2t025184001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025184001.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t025184001.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t025184001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t025184001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t025184002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025184002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025184002.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	InterPro
NV2t025184002.1	biological_process	GO:0030198	extracellular matrix organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]	OMA
NV2t025184002.1	cellular_component	GO:0031012	extracellular matrix	"A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]	PANTHER
NV2t025184002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t025184002.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t025184002.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t025185001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025186001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025188001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025190001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	OMA
NV2t025190001.1	biological_process	GO:0006261	DNA-templated DNA replication	"A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t025190001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t025191001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	InterPro
NV2t025191001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	OMA
NV2t025191001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	PANTHER
NV2t025191001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t025191001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025191001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025191001.1	molecular_function	GO:0005262	calcium channel activity	"Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]	OMA
NV2t025193001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025193001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025194001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025194001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025195001.1	biological_process	GO:0007154	cell communication	"Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]	OMA
NV2t025195001.1	biological_process	GO:0010975	regulation of neuron projection development	"Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]	OMA
NV2t025195001.1	biological_process	GO:0023052	signaling	"The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]	OMA
NV2t025195001.1	biological_process	GO:0046928	regulation of neurotransmitter secretion	"Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai]	OMA
NV2t025195001.1	biological_process	GO:0050896	response to stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]	OMA
NV2t025195001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025195001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025195001.1	cellular_component	GO:0036477	somatodendritic compartment	"The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL]	OMA
NV2t025195001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t025195001.1	molecular_function	GO:0005245	voltage-gated calcium channel activity	"Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]	OMA
NV2t025195001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025195001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025195001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t025195001.1	molecular_function	GO:0008048	calcium sensitive guanylate cyclase activator activity	"Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah]	OMA
NV2t025195001.1	molecular_function	GO:0008048	calcium sensitive guanylate cyclase activator activity	"Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah]	PANTHER
NV2t025203001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t025203001.1	biological_process	GO:0006900	vesicle budding from membrane	"The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb]	OMA
NV2t025203001.1	biological_process	GO:0006903	vesicle targeting	"The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]	OMA
NV2t025203001.1	biological_process	GO:0006914	autophagy	"The cellular catabolic process in which cells digest cellular materials, such as organelles and other macromolecular constituents, or non-self materials such as intracellular pathogens. Autophagy serves to provide essential nutrients under conditions of cellular stress; or can remodel intracellular structures during cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:29455577, PMID:9412464]	OMA
NV2t025203001.1	biological_process	GO:0065003	protein-containing complex assembly	"The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl]	OMA
NV2t025203001.1	biological_process	GO:0070973	protein localization to endoplasmic reticulum exit site	"A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah]	PANTHER
NV2t025208001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t025208001.1	molecular_function	GO:0016791	phosphatase activity	"Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions." [GOC:curators, GOC:pg]	OMA
NV2t025209001.1	biological_process	GO:0001954	positive regulation of cell-matrix adhesion	"Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd]	OMA
NV2t025209001.1	biological_process	GO:0006405	RNA export from nucleus	"The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t025209001.1	biological_process	GO:0007160	cell-matrix adhesion	"The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]	OMA
NV2t025209001.1	biological_process	GO:0008285	negative regulation of cell population proliferation	"Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]	OMA
NV2t025209001.1	biological_process	GO:0008344	adult locomotory behavior	"Locomotory behavior in a fully developed and mature organism." [GOC:ai]	OMA
NV2t025209001.1	biological_process	GO:0016242	negative regulation of macroautophagy	"Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]	OMA
NV2t025209001.1	biological_process	GO:0017148	negative regulation of translation	"Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	OMA
NV2t025209001.1	biological_process	GO:0031669	cellular response to nutrient levels	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]	OMA
NV2t025209001.1	biological_process	GO:0032007	negative regulation of TOR signaling	"Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah]	OMA
NV2t025209001.1	biological_process	GO:0032780	negative regulation of ATP-dependent activity	"Any process that stops or reduces the rate of an ATP-dependent activity." [GOC:mah]	OMA
NV2t025209001.1	biological_process	GO:0032868	response to insulin	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732]	OMA
NV2t025209001.1	biological_process	GO:0036294	cellular response to decreased oxygen levels	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]	OMA
NV2t025209001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t025209001.1	biological_process	GO:0043666	regulation of phosphoprotein phosphatase activity	"Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]	OMA
NV2t025209001.1	biological_process	GO:0050821	protein stabilization	"Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]	OMA
NV2t025209001.1	biological_process	GO:0051492	regulation of stress fiber assembly	"Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]	OMA
NV2t025209001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	OMA
NV2t025209001.1	biological_process	GO:0051726	regulation of cell cycle	"Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]	PANTHER
NV2t025209001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t025209001.1	biological_process	GO:1901214	obsolete regulation of neuron death	"OBSOLETE. Any process that modulates the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie]	OMA
NV2t025209001.1	biological_process	GO:1901890	positive regulation of cell junction assembly	"Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie]	OMA
NV2t025209001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025209001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t025209001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t025209001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025209001.1	cellular_component	GO:0030027	lamellipodium	"A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]	OMA
NV2t025209001.1	cellular_component	GO:0033596	TSC1-TSC2 complex	"A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671]	OMA
NV2t025209001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t025209001.1	cellular_component	GO:0101031	protein folding chaperone complex	"A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797]	OMA
NV2t025209001.1	molecular_function	GO:0030544	Hsp70 protein binding	"Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732]	OMA
NV2t025209001.1	molecular_function	GO:0047485	obsolete protein N-terminus binding	"OBSOLETE. Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732]	OMA
NV2t025209001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	OMA
NV2t025209001.1	molecular_function	GO:0051879	Hsp90 protein binding	"Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]	OMA
NV2t025209001.1	molecular_function	GO:0060590	ATPase regulator activity	"Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb]	OMA
NV2t025209001.1	molecular_function	GO:0140678	molecular function inhibitor activity	"A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators]	OMA
NV2t025210001.1	biological_process	GO:0042254	ribosome biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis]	OMA
NV2t025210001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t025210001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	InterPro
NV2t025210001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t025211001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025211001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t025211001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t025211001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t025211001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t025212001.1	biological_process	GO:0000387	spliceosomal snRNP assembly	"The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]	OMA
NV2t025212001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t025212001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	InterPro
NV2t025212001.1	cellular_component	GO:0032797	SMN complex	"A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]	OMA
NV2t025213001.1	biological_process	GO:0051301	cell division	"The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]	InterPro
NV2t025214001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025214001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	PANTHER
NV2t025214001.1	molecular_function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	"Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2]	OMA
NV2t025214001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025214001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025214001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025216001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t025216001.1	biological_process	GO:0071345	cellular response to cytokine stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]	OMA
NV2t025216001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025216001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025216001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t025216001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	PANTHER
NV2t025216001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025216001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t025218001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t025218001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t025218001.1	biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	"The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]	PANTHER
NV2t025219002.1	cellular_component	GO:0071011	precatalytic spliceosome	"A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]	PANTHER
NV2t025221001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025221002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025221003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025222001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t025222001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025222001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t025223001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025224001.1	molecular_function	GO:0004842	ubiquitin-protein transferase activity	"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]	OMA
NV2t025224001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025224001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t025225001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025228001.1	biological_process	GO:0007218	neuropeptide signaling pathway	"A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process." [GOC:mah, ISBN:0815316194]	OMA
NV2t025228001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025228001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t025229001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025229001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	OMA
NV2t025229001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t025229001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t025229001.1	molecular_function	GO:0002020	protease binding	"Binding to a protease or a peptidase." [GOC:hjd]	OMA
NV2t025229001.1	molecular_function	GO:0070513	death domain binding	"Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]	InterPro
NV2t025229001.1	molecular_function	GO:0070513	death domain binding	"Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]	OMA
NV2t025230001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t025230001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025230002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025231001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t025231001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025231001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025232001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025232001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025232001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	PANTHER
NV2t025233001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t025233001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025233001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025233001.1	molecular_function	GO:0005228	intracellular sodium-activated potassium channel activity	"Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167]	OMA
NV2t025233001.1	molecular_function	GO:0015271	outward rectifier potassium channel activity	"Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]	OMA
NV2t025235001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025237001.1	biological_process	GO:0007266	Rho protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Rho subfamily relays a signal." [GOC:bf]	OMA
NV2t025237001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025237001.1	cellular_component	GO:0009986	cell surface	"The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]	OMA
NV2t025237001.1	molecular_function	GO:0005035	death receptor activity	"Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death." [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]	OMA
NV2t025237001.1	molecular_function	GO:0015026	coreceptor activity	"Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]	OMA
NV2t025237001.1	molecular_function	GO:0043121	neurotrophin binding	"Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl]	OMA
NV2t025237001.1	molecular_function	GO:0048406	nerve growth factor binding	"Binding to nerve growth factor (NGF)." [GOC:dgh]	PANTHER
NV2t025238001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025238002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025239001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t025239001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025239001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025239002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025240001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t025240001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025240001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025243001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t025243001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025243001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025244001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025244001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t025245001.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t025245001.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t025245002.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t025245002.1	biological_process	GO:0007265	Ras protein signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal." [GOC:bf]	OMA
NV2t025245002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	OMA
NV2t025245002.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t025245002.1	biological_process	GO:0046578	regulation of Ras protein signal transduction	"Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]	OMA
NV2t025245002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025245002.1	molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	"Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]	OMA
NV2t025245003.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t025245003.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t025245004.1	biological_process	GO:0007264	small GTPase-mediated signal transduction	"An intracellular signaling cassette in which a small monomeric GTPase relays a signal." [GOC:mah]	InterPro
NV2t025245004.1	biological_process	GO:0043547	positive regulation of GTPase activity	"Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah]	PANTHER
NV2t025246001.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t025246001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t025246001.1	biological_process	GO:0042274	ribosomal small subunit biogenesis	"A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]	OMA
NV2t025246001.1	biological_process	GO:0051254	positive regulation of RNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]	OMA
NV2t025246001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025246001.1	cellular_component	GO:0030688	preribosome, small subunit precursor	"A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]	PANTHER
NV2t025246001.1	cellular_component	GO:0034708	methyltransferase complex	"A protein complex that possesses methyltransferase activity." [GOC:mah]	OMA
NV2t025246001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t025246001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	InterPro
NV2t025246001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t025246001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025246001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025247002.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	InterPro
NV2t025247002.1	biological_process	GO:0006364	rRNA processing	"Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]	OMA
NV2t025247002.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	InterPro
NV2t025247002.1	biological_process	GO:0031053	primary miRNA processing	"A process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354, PMID:25799998]	OMA
NV2t025247002.1	biological_process	GO:0031054	pre-miRNA processing	"A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]	InterPro
NV2t025247002.1	biological_process	GO:0031054	pre-miRNA processing	"A process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]	OMA
NV2t025247002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025247002.1	cellular_component	GO:0070877	microprocessor complex	"A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994]	PANTHER
NV2t025247002.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t025247002.1	molecular_function	GO:0004525	ribonuclease III activity	"Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]	OMA
NV2t025249001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025249001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025249001.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t025249002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025249002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025249002.1	molecular_function	GO:0008234	cysteine-type peptidase activity	"Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t025250001.1	molecular_function	GO:0055105	ubiquitin-protein transferase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl]	PANTHER
NV2t025250002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t025250002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025250003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025250003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025250003.1	molecular_function	GO:0055105	ubiquitin-protein transferase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl]	PANTHER
NV2t025250004.1	molecular_function	GO:0055105	ubiquitin-protein transferase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl]	PANTHER
NV2t025250005.1	molecular_function	GO:0055105	ubiquitin-protein transferase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl]	PANTHER
NV2t025251001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t025251001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025251001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025252001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t025252001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025252001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025253001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t025253001.1	biological_process	GO:0002253	activation of immune response	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t025253001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025253001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025253001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	PANTHER
NV2t025253001.1	biological_process	GO:0006959	humoral immune response	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]	OMA
NV2t025253001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t025253001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t025255001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025259001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025259001.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t025259002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025259002.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t025259003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025259003.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t025259004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025259004.1	molecular_function	GO:0017056	structural constituent of nuclear pore	"The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992]	PANTHER
NV2t025260001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t025260001.1	biological_process	GO:0101030	tRNA-guanine transglycosylation	"The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine." [GOC:PomBase, GOC:vw, PMID:24911101]	InterPro
NV2t025260001.1	biological_process	GO:0101030	tRNA-guanine transglycosylation	"The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine." [GOC:PomBase, GOC:vw, PMID:24911101]	PANTHER
NV2t025260001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t025260001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t025260001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t025261001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025261001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025261002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025261002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025261003.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025262001.1	biological_process	GO:0019628	urate catabolic process	"The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732]	PANTHER
NV2t025263001.1	biological_process	GO:0032874	positive regulation of stress-activated MAPK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]	PANTHER
NV2t025263001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025263002.1	biological_process	GO:0032874	positive regulation of stress-activated MAPK cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]	PANTHER
NV2t025263002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025264001.1	molecular_function	GO:0045505	dynein intermediate chain binding	"Binding to an intermediate chain of the dynein complex." [GOC:bf]	PANTHER
NV2t025266001.1	biological_process	GO:0060700	regulation of ribonuclease activity	"Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]	PANTHER
NV2t025266001.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t025266002.1	biological_process	GO:0060700	regulation of ribonuclease activity	"Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]	PANTHER
NV2t025266002.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t025266003.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t025266003.1	biological_process	GO:0060700	regulation of ribonuclease activity	"Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]	PANTHER
NV2t025266003.1	molecular_function	GO:0003725	double-stranded RNA binding	"Binding to double-stranded RNA." [GOC:jl]	OMA
NV2t025266003.1	molecular_function	GO:0016779	nucleotidyltransferase activity	"Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]	InterPro
NV2t025266003.1	molecular_function	GO:0070566	adenylyltransferase activity	"Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]	OMA
NV2t025269001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t025269001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	InterPro
NV2t025270002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025270002.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025270002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025270003.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025270003.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025270003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025270003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025273001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t025273001.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t025273001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025273002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	InterPro
NV2t025273002.1	biological_process	GO:0007155	cell adhesion	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]	PANTHER
NV2t025273002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025275001.1	cellular_component	GO:1990298	bub1-bub3 complex	"Protein complex that associates with the kinetochores." [PMID:22521786]	PANTHER
NV2t025275001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025276001.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t025276001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t025276001.1	biological_process	GO:0070584	obsolete mitochondrion morphogenesis	"OBSOLETE. The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah]	OMA
NV2t025276001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025276001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025276001.1	molecular_function	GO:0016530	metallochaperone activity	"Binding to and delivering metal ions to a target protein." [PMID:11739376]	OMA
NV2t025276001.1	molecular_function	GO:0051536	iron-sulfur cluster binding	"Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]	OMA
NV2t025276001.1	molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	"Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	PANTHER
NV2t025276001.1	molecular_function	GO:0140657	ATP-dependent activity	"A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]	OMA
NV2t025276001.1	molecular_function	GO:0140663	ATP-dependent FeS chaperone activity	"Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis." [PMID:16843540]	InterPro
NV2t025277001.1	cellular_component	GO:0000786	nucleosome	"A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]	OMA
NV2t025277001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025277001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025277001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	InterPro
NV2t025277001.1	molecular_function	GO:0030527	structural constituent of chromatin	"The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]	OMA
NV2t025277001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t025277001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	OMA
NV2t025278001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025278001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025278001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025278001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025280001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025281001.1	biological_process	GO:0042138	meiotic DNA double-strand break formation	"The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]	InterPro
NV2t025281001.1	biological_process	GO:0048477	oogenesis	"The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr]	PANTHER
NV2t025282001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025282001.1	molecular_function	GO:0046920	alpha-(1->3)-fucosyltransferase activity	"Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai]	PANTHER
NV2t025283001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025283001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025286001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t025286001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t025286001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t025286001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t025286001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025286001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025286001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025286001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t025287001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	OMA
NV2t025287001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	OMA
NV2t025287001.1	biological_process	GO:0009755	hormone-mediated signaling pathway	"The series of molecular signals mediated by the detection of a hormone." [GOC:sm]	PANTHER
NV2t025287001.1	biological_process	GO:0045762	positive regulation of adenylate cyclase activity	"Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]	OMA
NV2t025287001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025287001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025287001.1	molecular_function	GO:0008528	G protein-coupled peptide receptor activity	"Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb]	OMA
NV2t025289001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025289001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t025289001.1	biological_process	GO:0048568	embryonic organ development	"Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid]	OMA
NV2t025289001.1	biological_process	GO:0048666	neuron development	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]	OMA
NV2t025289001.1	biological_process	GO:0048666	neuron development	"The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]	PANTHER
NV2t025289001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t025289001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025289001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025289001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025289001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025290001.1	biological_process	GO:0043087	regulation of GTPase activity	"Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah]	InterPro
NV2t025290001.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t025290002.1	molecular_function	GO:0031267	small GTPase binding	"Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782]	PANTHER
NV2t025291001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t025291001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t025291001.1	biological_process	GO:0016525	negative regulation of angiogenesis	"Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]	InterPro
NV2t025291001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025291001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025291002.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	InterPro
NV2t025291002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t025291002.1	biological_process	GO:0016525	negative regulation of angiogenesis	"Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]	InterPro
NV2t025291002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025291002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025292001.1	biological_process	GO:0007186	G protein-coupled receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]	PANTHER
NV2t025292001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025292001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025293001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025293001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025293002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025293003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025296001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025296001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025299001.1	biological_process	GO:0006520	amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]	OMA
NV2t025299001.1	biological_process	GO:0007275	multicellular organism development	"The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]	OMA
NV2t025299001.1	biological_process	GO:0042221	response to chemical	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]	OMA
NV2t025299001.1	biological_process	GO:0042416	dopamine biosynthetic process	"The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]	OMA
NV2t025299001.1	biological_process	GO:0042427	serotonin biosynthetic process	"The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]	OMA
NV2t025299001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025299001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	InterPro
NV2t025299001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	PANTHER
NV2t025299001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t025299001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t025299001.1	molecular_function	GO:0036468	L-dopa decarboxylase activity	"Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine." [GOC:bf, GOC:PARL, RHEA:12272]	OMA
NV2t025301001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t025301001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t025301001.1	biological_process	GO:0007269	neurotransmitter secretion	"The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph]	OMA
NV2t025301001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t025301001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025301001.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	OMA
NV2t025301001.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t025301001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t025301002.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t025301002.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t025302001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t025302001.1	biological_process	GO:0006904	vesicle docking involved in exocytosis	"The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915]	OMA
NV2t025302001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t025302001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025302001.1	cellular_component	GO:0030141	secretory granule	"A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t025302001.1	molecular_function	GO:0019905	syntaxin binding	"Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732]	OMA
NV2t025304001.1	cellular_component	GO:0071818	BAT3 complex	"A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303]	PANTHER
NV2t025304001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025304002.1	biological_process	GO:0030433	obsolete ubiquitin-dependent ERAD pathway	"OBSOLETE. The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]	OMA
NV2t025304002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025304002.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t025304002.1	cellular_component	GO:0071818	BAT3 complex	"A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303]	PANTHER
NV2t025304002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025304002.1	molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	"Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg]	OMA
NV2t025305001.1	biological_process	GO:0006458	'de novo' protein folding	"The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]	OMA
NV2t025305001.1	biological_process	GO:0007029	endoplasmic reticulum organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t025305001.1	biological_process	GO:0034504	protein localization to nucleus	"A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd]	OMA
NV2t025305001.1	biological_process	GO:0051085	chaperone cofactor-dependent protein refolding	"The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]	InterPro
NV2t025305001.1	biological_process	GO:0061077	chaperone-mediated protein folding	"The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw]	OMA
NV2t025305001.1	biological_process	GO:0071218	cellular response to misfolded protein	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]	OMA
NV2t025305001.1	biological_process	GO:0071763	nuclear membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah]	OMA
NV2t025305001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t025305001.1	cellular_component	GO:0005788	endoplasmic reticulum lumen	"The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]	OMA
NV2t025305001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025305001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025305001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025305001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t025305001.1	molecular_function	GO:0019894	kinesin binding	"Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779]	OMA
NV2t025305001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t025306001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	OMA
NV2t025306001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t025306001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025306001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	InterPro
NV2t025306001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t025307001.1	cellular_component	GO:0071818	BAT3 complex	"A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303]	PANTHER
NV2t025308001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025308001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025308001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025308001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t025309001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t025311001.1	biological_process	GO:0061024	membrane organization	"A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]	PANTHER
NV2t025311001.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	InterPro
NV2t025312001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	InterPro
NV2t025312001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t025312001.1	biological_process	GO:0051014	actin filament severing	"The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]	OMA
NV2t025312001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025312001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t025312001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t025312001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t025312001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t025312002.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	InterPro
NV2t025312002.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t025312002.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t025317001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	InterPro
NV2t025317001.1	biological_process	GO:0030042	actin filament depolymerization	"Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]	OMA
NV2t025317001.1	biological_process	GO:0051014	actin filament severing	"The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]	OMA
NV2t025317001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025317001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t025317001.1	molecular_function	GO:0003779	actin binding	"Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]	InterPro
NV2t025317001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t025317001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t025319001.1	cellular_component	GO:0009941	chloroplast envelope	"The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]	PANTHER
NV2t025320001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	OMA
NV2t025320001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t025320001.1	cellular_component	GO:0022625	cytosolic large ribosomal subunit	"The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu]	PANTHER
NV2t025320001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t025321001.1	biological_process	GO:0008104	protein localization	"Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai]	OMA
NV2t025321001.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t025321002.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t025321003.1	cellular_component	GO:0012505	endomembrane system	"A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]	PANTHER
NV2t025323001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t025323001.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t025323001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025323001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025323001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t025323001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t025323001.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	OMA
NV2t025323001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025323001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t025323002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t025323002.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t025323002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025323002.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t025323002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025323003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t025323003.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t025323003.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025323003.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t025323003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025323004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t025323004.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t025323004.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025323004.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t025323004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025323005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t025323005.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t025323005.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025323005.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t025323005.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025323006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	PANTHER
NV2t025323006.1	molecular_function	GO:0000166	nucleotide binding	"Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]	InterPro
NV2t025323006.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025323006.1	molecular_function	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	"Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]	InterPro
NV2t025323006.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025324001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t025324001.1	biological_process	GO:0006906	vesicle fusion	"Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid]	OMA
NV2t025324001.1	biological_process	GO:0016192	vesicle-mediated transport	"A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]	InterPro
NV2t025324001.1	biological_process	GO:0042147	retrograde transport, endosome to Golgi	"The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]	OMA
NV2t025324001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	InterPro
NV2t025324001.1	biological_process	GO:0048193	Golgi vesicle transport	"The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233]	OMA
NV2t025324001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	OMA
NV2t025324001.1	biological_process	GO:0048278	vesicle docking	"The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid]	PANTHER
NV2t025324001.1	biological_process	GO:0065007	biological regulation	"Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]	OMA
NV2t025324001.1	cellular_component	GO:0005769	early endosome	"A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]	OMA
NV2t025324001.1	cellular_component	GO:0030672	synaptic vesicle membrane	"The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]	OMA
NV2t025324001.1	cellular_component	GO:0031201	SNARE complex	"A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911]	OMA
NV2t025324001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t025324001.1	molecular_function	GO:0000149	SNARE binding	"Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]	OMA
NV2t025324001.1	molecular_function	GO:0005484	SNAP receptor activity	"Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]	OMA
NV2t025325001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t025325001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	PANTHER
NV2t025325001.1	biological_process	GO:0007163	establishment or maintenance of cell polarity	"Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]	OMA
NV2t025325001.1	biological_process	GO:0060341	regulation of cellular localization	"Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]	OMA
NV2t025325001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025325001.1	cellular_component	GO:0005938	cell cortex	"The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]	OMA
NV2t025325001.1	cellular_component	GO:0016324	apical plasma membrane	"The region of the plasma membrane located at the apical end of the cell." [GOC:curators]	OMA
NV2t025325001.1	molecular_function	GO:0005080	protein kinase C binding	"Binding to protein kinase C." [GOC:jl]	OMA
NV2t025325001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025327001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025328001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	InterPro
NV2t025328001.1	molecular_function	GO:0050681	nuclear androgen receptor binding	"Binding to a nuclear androgen receptor." [GOC:ai]	PANTHER
NV2t025329001.1	molecular_function	GO:0005324	long-chain fatty acid transmembrane transporter activity	"Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons." [ISBN:0198506732]	PANTHER
NV2t025330001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025331001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025331001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025331001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025331001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t025331001.1	molecular_function	GO:0035064	methylated histone binding	"Binding to a histone in which a residue has been modified by methylation." [GOC:bf, PMID:14585615]	OMA
NV2t025331001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t025331001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA
NV2t025331002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025331002.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t025331003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025331003.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t025331005.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025332001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025332002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025332003.1	biological_process	GO:0000209	protein polyubiquitination	"Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]	OMA
NV2t025332003.1	biological_process	GO:0002831	regulation of response to biotic stimulus	"Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]	OMA
NV2t025332003.1	biological_process	GO:0019058	viral life cycle	"A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]	OMA
NV2t025332003.1	biological_process	GO:0030163	protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]	OMA
NV2t025332003.1	biological_process	GO:0031349	positive regulation of defense response	"Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah]	OMA
NV2t025332003.1	biological_process	GO:0032103	positive regulation of response to external stimulus	"Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]	OMA
NV2t025332003.1	biological_process	GO:0045806	negative regulation of endocytosis	"Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators]	OMA
NV2t025332003.1	biological_process	GO:0051865	protein autoubiquitination	"The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]	OMA
NV2t025332003.1	biological_process	GO:0070086	ubiquitin-dependent endocytosis	"Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded." [GOC:jp, GOC:mah, PMID:9409540]	OMA
NV2t025332003.1	biological_process	GO:2000786	positive regulation of autophagosome assembly	"Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF]	OMA
NV2t025332003.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025332003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025332003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025332003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t025332004.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025332005.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025332006.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025332007.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025333001.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t025334001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025334001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t025334001.1	biological_process	GO:0006970	response to osmotic stress	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]	OMA
NV2t025334001.1	biological_process	GO:0009408	response to heat	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]	OMA
NV2t025334001.1	biological_process	GO:0009411	response to UV	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]	OMA
NV2t025334001.1	biological_process	GO:0009605	response to external stimulus	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]	OMA
NV2t025334001.1	biological_process	GO:0034612	response to tumor necrosis factor	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]	OMA
NV2t025334001.1	biological_process	GO:0043406	positive regulation of MAP kinase activity	"Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]	OMA
NV2t025334001.1	biological_process	GO:0043506	regulation of JUN kinase activity	"Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl]	OMA
NV2t025334001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025334001.1	biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	"Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]	OMA
NV2t025334001.1	biological_process	GO:0080135	regulation of cellular response to stress	"Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]	OMA
NV2t025334001.1	biological_process	GO:2000573	positive regulation of DNA biosynthetic process	"Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]	OMA
NV2t025334001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t025334001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025334001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025334001.1	molecular_function	GO:0000287	magnesium ion binding	"Binding to a magnesium (Mg) ion." [GOC:ai]	OMA
NV2t025334001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025334001.1	molecular_function	GO:0008545	JUN kinase kinase activity	"Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549]	OMA
NV2t025334001.1	molecular_function	GO:0019901	protein kinase binding	"Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]	OMA
NV2t025334001.1	molecular_function	GO:0019903	protein phosphatase binding	"Binding to a protein phosphatase." [GOC:jl]	OMA
NV2t025334002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025335001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025336001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t025336001.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t025336001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025336001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025336001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025336002.1	biological_process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]	PANTHER
NV2t025336002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025337001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t025338001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t025339001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t025340001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t025344001.1	molecular_function	GO:0050211	procollagen galactosyltransferase activity	"Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN]	OMA
NV2t025344001.1	molecular_function	GO:0050211	procollagen galactosyltransferase activity	"Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN]	PANTHER
NV2t025347001.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t025347002.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t025347002.1	biological_process	GO:0002253	activation of immune response	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t025347002.1	biological_process	GO:0006959	humoral immune response	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]	OMA
NV2t025347002.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t025347002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	InterPro
NV2t025347002.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t025347002.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t025347002.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	OMA
NV2t025347002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025347003.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t025347004.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t025347005.1	molecular_function	GO:0004866	endopeptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of an endopeptidase." [GOC:jl]	InterPro
NV2t025349001.1	biological_process	GO:0051017	actin filament bundle assembly	"The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]	OMA
NV2t025349001.1	biological_process	GO:0097178	ruffle assembly	"The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42." [GOC:yaf, http:en.wikipedia.org/wiki/Membrane_ruffling, PMID:12556481]	PANTHER
NV2t025349001.1	biological_process	GO:0120031	plasma membrane bounded cell projection assembly	"Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc]	OMA
NV2t025349001.1	cellular_component	GO:0001726	ruffle	"Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]	OMA
NV2t025349001.1	cellular_component	GO:0005884	actin filament	"A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339]	OMA
NV2t025349001.1	cellular_component	GO:0031253	cell projection membrane	"The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah]	OMA
NV2t025349001.1	cellular_component	GO:0031256	leading edge membrane	"The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]	OMA
NV2t025349001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025349001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025349001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	OMA
NV2t025351001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	PANTHER
NV2t025351001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t025352001.1	biological_process	GO:0006520	amino acid metabolic process	"The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups." [ISBN:0198506732]	OMA
NV2t025352001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	InterPro
NV2t025352001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	OMA
NV2t025352001.1	molecular_function	GO:0016831	carboxy-lyase activity	"Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators]	PANTHER
NV2t025352001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t025352001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t025353001.1	biological_process	GO:0046856	phosphatidylinositol dephosphorylation	"The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732]	InterPro
NV2t025355001.1	biological_process	GO:0007051	spindle organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah]	OMA
NV2t025355001.1	biological_process	GO:0051295	establishment of meiotic spindle localization	"The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]	PANTHER
NV2t025355001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025356001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t025357001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t025357001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	OMA
NV2t025357001.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t025357001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t025357001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t025357001.1	biological_process	GO:0048519	negative regulation of biological process	"Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t025357001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t025357001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t025357001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t025357001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t025357001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t025357001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025357001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025357002.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t025357002.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t025357002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025357003.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t025357003.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t025357003.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025357004.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t025357004.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t025357004.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025357005.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t025357005.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t025357005.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025357006.1	biological_process	GO:0006406	mRNA export from nucleus	"The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]	PANTHER
NV2t025357006.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	InterPro
NV2t025357006.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025359001.1	biological_process	GO:0002252	immune effector process	"Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t025359001.1	biological_process	GO:0002253	activation of immune response	"Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149]	OMA
NV2t025359001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025359001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025359001.1	biological_process	GO:0006956	complement activation	"Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149]	InterPro
NV2t025359001.1	biological_process	GO:0006959	humoral immune response	"An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732]	OMA
NV2t025359001.1	biological_process	GO:0009617	response to bacterium	"Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]	OMA
NV2t025359001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t025359001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025359001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t025359001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t025361001.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	InterPro
NV2t025361001.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	OMA
NV2t025361001.1	biological_process	GO:0008053	mitochondrial fusion	"Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192, PMID:12052774]	PANTHER
NV2t025363001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	OMA
NV2t025363001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t025363001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t025363001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025363001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025363001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t025363001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025363001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025363001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t025369001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t025369001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t025372001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025372002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025374001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t025374001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t025376001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376002.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376003.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376004.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376004.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376005.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376005.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376006.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376006.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376007.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376007.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376008.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376008.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376009.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376009.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025376010.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025376010.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025378002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t025379001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	InterPro
NV2t025379001.1	biological_process	GO:0043248	proteasome assembly	"The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]	OMA
NV2t025379001.1	cellular_component	GO:0022624	proteasome accessory complex	"A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]	OMA
NV2t025380001.1	biological_process	GO:0034975	protein folding in endoplasmic reticulum	"A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw]	PANTHER
NV2t025380002.1	biological_process	GO:0034975	protein folding in endoplasmic reticulum	"A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw]	PANTHER
NV2t025383001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t025383001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025383001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025383001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025383001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t025383001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025385001.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	PANTHER
NV2t025385002.1	cellular_component	GO:0032580	Golgi cisterna membrane	"The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]	PANTHER
NV2t025386001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	InterPro
NV2t025386001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t025388001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t025390001.1	biological_process	GO:0010424	obsolete DNA methylation on cytosine within a CG sequence	"OBSOLETE. The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600]	PANTHER
NV2t025390001.1	biological_process	GO:0010629	negative regulation of gene expression	"Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	OMA
NV2t025390001.1	biological_process	GO:0019219	regulation of nucleobase-containing compound metabolic process	"Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]	OMA
NV2t025390001.1	biological_process	GO:0090116	obsolete C-5 methylation of cytosine	"OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]	InterPro
NV2t025390001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025390001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025390001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	InterPro
NV2t025390001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t025390001.1	molecular_function	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]	OMA
NV2t025390001.1	molecular_function	GO:0008168	methyltransferase activity	"Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732]	InterPro
NV2t025390001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025390001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025395001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025397001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025397001.1	biological_process	GO:0006956	complement activation	"Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149]	InterPro
NV2t025404001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025407001.1	biological_process	GO:0006750	glutathione biosynthetic process	"The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732]	OMA
NV2t025407001.1	biological_process	GO:0035229	positive regulation of glutamate-cysteine ligase activity	"Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate." [PMID:12954617]	PANTHER
NV2t025407001.1	molecular_function	GO:0035226	glutamate-cysteine ligase catalytic subunit binding	"Binding to the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617]	OMA
NV2t025408001.1	biological_process	GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]	OMA
NV2t025408001.1	biological_process	GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t025408001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025408001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025408001.1	molecular_function	GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	"Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate." [PMID:22622228]	OMA
NV2t025408001.1	molecular_function	GO:0017018	myosin phosphatase activity	"Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]	OMA
NV2t025408001.1	molecular_function	GO:0043175	RNA polymerase core enzyme binding	"Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme." [GOC:jl, GOC:txnOH]	OMA
NV2t025410001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025412001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025412002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025415001.1	biological_process	GO:0015871	choline transport	"The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]	PANTHER
NV2t025415001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025415001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025415001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t025416001.1	biological_process	GO:0006400	tRNA modification	"The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]	OMA
NV2t025416001.1	biological_process	GO:0101030	tRNA-guanine transglycosylation	"The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine." [GOC:PomBase, GOC:vw, PMID:24911101]	PANTHER
NV2t025416001.1	molecular_function	GO:0008479	tRNA-guanosine(34) queuine transglycosylase activity	"Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA." [RHEA:16633]	InterPro
NV2t025416001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t025416001.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t025416002.1	biological_process	GO:0101030	tRNA-guanine transglycosylation	"The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine." [GOC:PomBase, GOC:vw, PMID:24911101]	PANTHER
NV2t025416002.1	molecular_function	GO:0016763	pentosyltransferase activity	"Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t025417001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t025417002.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t025417003.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t025419001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025419002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025419002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025419002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025419002.1	molecular_function	GO:0015220	choline transmembrane transporter activity	"Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]	OMA
NV2t025419003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025419004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025419005.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025419006.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025420001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025420001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025420002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025420002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025420003.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025420003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025420004.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025420004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025421001.1	cellular_component	GO:0005654	nucleoplasm	"That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]	OMA
NV2t025421001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025421001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t025422001.1	biological_process	GO:0034587	piRNA processing	"A process leading to the generation of a functional piRNA. piRNAs (Piwi-associated RNAs) are a class of 24- to 30-nucleotide RNAs derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:23329111, PMID:24696457, PMID:34724117]	PANTHER
NV2t025424001.1	biological_process	GO:0006612	protein targeting to membrane	"The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators]	OMA
NV2t025424001.1	biological_process	GO:0018198	peptidyl-cysteine modification	"The modification of peptidyl-cysteine." [GOC:go_curators]	OMA
NV2t025424001.1	biological_process	GO:0018345	protein palmitoylation	"The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806]	OMA
NV2t025424001.1	biological_process	GO:0032228	regulation of synaptic transmission, GABAergic	"Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]	OMA
NV2t025424001.1	biological_process	GO:0035418	protein localization to synapse	"Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf]	OMA
NV2t025424001.1	biological_process	GO:0050806	positive regulation of synaptic transmission	"Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]	OMA
NV2t025424001.1	biological_process	GO:0070925	organelle assembly	"The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]	OMA
NV2t025424001.1	biological_process	GO:0097106	postsynaptic density organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273]	OMA
NV2t025424001.1	biological_process	GO:0099068	postsynapse assembly	"The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL]	OMA
NV2t025424001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t025424001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t025424001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	InterPro
NV2t025424001.1	molecular_function	GO:0016409	palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]	OMA
NV2t025424001.1	molecular_function	GO:0019706	protein-cysteine S-palmitoyltransferase activity	"Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683]	PANTHER
NV2t025424001.1	molecular_function	GO:0140096	catalytic activity, acting on a protein	"Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t025426001.1	biological_process	GO:0016125	sterol metabolic process	"The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]	OMA
NV2t025426001.1	molecular_function	GO:0004497	monooxygenase activity	"Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732]	OMA
NV2t025426001.1	molecular_function	GO:0005506	iron ion binding	"Binding to an iron (Fe) ion." [GOC:ai]	OMA
NV2t025426001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t025426001.1	molecular_function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	"Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]	OMA
NV2t025426001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t025426001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	OMA
NV2t025427001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t025427001.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t025427002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t025427002.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t025427003.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	PANTHER
NV2t025427003.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t025427004.1	molecular_function	GO:0020037	heme binding	"Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai]	InterPro
NV2t025428001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t025428001.1	biological_process	GO:0030166	proteoglycan biosynthetic process	"The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]	OMA
NV2t025428001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t025428001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	OMA
NV2t025428001.1	molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	"Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]	PANTHER
NV2t025429001.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t025429002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	InterPro
NV2t025429002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	OMA
NV2t025429002.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t025429003.1	cellular_component	GO:0016592	mediator complex	"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]	PANTHER
NV2t025430001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025430002.1	biological_process	GO:0016226	iron-sulfur cluster assembly	"The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]	OMA
NV2t025430002.1	biological_process	GO:0051604	protein maturation	"Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]	OMA
NV2t025430002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025430002.1	cellular_component	GO:0005819	spindle	"The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]	OMA
NV2t025430002.1	cellular_component	GO:0097361	CIA complex	"The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362]	InterPro
NV2t025430002.1	cellular_component	GO:0097361	CIA complex	"The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362]	PANTHER
NV2t025430002.1	cellular_component	GO:0140535	intracellular protein-containing complex	"A protein-containing complex located intracellularly." [GOC:pg]	OMA
NV2t025430002.1	molecular_function	GO:0003674	molecular_function	"A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs." [GOC:pdt]	OMA
NV2t025430002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025430003.1	cellular_component	GO:0097361	CIA complex	"The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362]	PANTHER
NV2t025430003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025430004.1	cellular_component	GO:0097361	CIA complex	"The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362]	PANTHER
NV2t025430004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025430005.1	cellular_component	GO:0097361	CIA complex	"The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362]	PANTHER
NV2t025430005.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025431001.1	biological_process	GO:0032922	circadian regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]	OMA
NV2t025431001.1	biological_process	GO:0043153	entrainment of circadian clock by photoperiod	"The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]	OMA
NV2t025431001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025431001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025431001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025431001.1	molecular_function	GO:0016830	carbon-carbon lyase activity	"Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]	OMA
NV2t025431001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	OMA
NV2t025431001.1	molecular_function	GO:0071949	FAD binding	"Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]	PANTHER
NV2t025431001.1	molecular_function	GO:0140097	catalytic activity, acting on DNA	"Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t025433001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	InterPro
NV2t025433001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	OMA
NV2t025433001.1	biological_process	GO:0061640	cytoskeleton-dependent cytokinesis	"A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph]	PANTHER
NV2t025433001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t025433001.1	cellular_component	GO:0005869	dynactin complex	"A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732]	OMA
NV2t025433001.1	cellular_component	GO:0048471	perinuclear region of cytoplasm	"Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid]	OMA
NV2t025434001.1	biological_process	GO:0009144	purine nucleoside triphosphate metabolic process	"The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t025434001.1	biological_process	GO:1901292	nucleoside phosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie]	OMA
NV2t025434001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025434001.1	molecular_function	GO:0042802	identical protein binding	"Binding to an identical protein or proteins." [GOC:jl]	OMA
NV2t025434001.1	molecular_function	GO:0047429	nucleoside triphosphate diphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]	InterPro
NV2t025434001.1	molecular_function	GO:0047429	nucleoside triphosphate diphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]	OMA
NV2t025434001.1	molecular_function	GO:0047429	nucleoside triphosphate diphosphatase activity	"Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate." [EC:3.6.1.9]	PANTHER
NV2t025436001.1	biological_process	GO:0000723	telomere maintenance	"Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]	OMA
NV2t025436001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	OMA
NV2t025436001.1	biological_process	GO:0090305	obsolete nucleic acid phosphodiester bond hydrolysis	"OBSOLETE. The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb]	PANTHER
NV2t025436001.1	cellular_component	GO:0030870	Mre11 complex	"Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]	InterPro
NV2t025436001.1	cellular_component	GO:0030870	Mre11 complex	"Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]	OMA
NV2t025436001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	OMA
NV2t025437001.1	biological_process	GO:0106034	protein maturation by [2Fe-2S] cluster transfer	"The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440]	PANTHER
NV2t025437001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t025437001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	InterPro
NV2t025437001.1	molecular_function	GO:0051537	2 iron, 2 sulfur cluster binding	"Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]	OMA
NV2t025438002.1	molecular_function	GO:0003839	gamma-glutamylcyclotransferase activity	"Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [PMID:18515354]	PANTHER
NV2t025439001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t025439001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t025439001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t025439001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t025439001.1	molecular_function	GO:0047874	dolichyldiphosphatase activity	"Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN]	PANTHER
NV2t025439002.1	molecular_function	GO:0047874	dolichyldiphosphatase activity	"Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN]	PANTHER
NV2t025440001.1	biological_process	GO:0006487	protein N-linked glycosylation	"A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]	OMA
NV2t025440001.1	biological_process	GO:0008610	lipid biosynthetic process	"The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]	OMA
NV2t025440001.1	cellular_component	GO:0005789	endoplasmic reticulum membrane	"The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]	OMA
NV2t025440001.1	molecular_function	GO:0016462	pyrophosphatase activity	"Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]	OMA
NV2t025442001.1	biological_process	GO:0035434	copper ion transmembrane transport	"The directed movement of copper cation across a membrane." [GOC:vw]	InterPro
NV2t025442002.1	biological_process	GO:0035434	copper ion transmembrane transport	"The directed movement of copper cation across a membrane." [GOC:vw]	InterPro
NV2t025444001.1	molecular_function	GO:0003950	NAD+ ADP-ribosyltransferase activity	"Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]	InterPro
NV2t025444001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025444001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	PANTHER
NV2t025446001.1	biological_process	GO:0030833	regulation of actin filament polymerization	"Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]	OMA
NV2t025446001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	InterPro
NV2t025446001.1	biological_process	GO:0034314	Arp2/3 complex-mediated actin nucleation	"The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]	OMA
NV2t025446001.1	cellular_component	GO:0015629	actin cytoskeleton	"The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194]	OMA
NV2t025446001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t025446001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t025448001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025448001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	OMA
NV2t025448001.1	molecular_function	GO:0061630	ubiquitin protein ligase activity	"Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777]	PANTHER
NV2t025449001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025450001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t025450001.1	biological_process	GO:0007030	Golgi organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t025450001.1	biological_process	GO:0032368	regulation of lipid transport	"Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]	OMA
NV2t025450001.1	biological_process	GO:0042953	lipoprotein transport	"The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]	OMA
NV2t025450001.1	biological_process	GO:0046907	intracellular transport	"The directed movement of substances within a cell." [GOC:ai]	OMA
NV2t025450001.1	biological_process	GO:0048518	positive regulation of biological process	"Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid]	OMA
NV2t025450001.1	biological_process	GO:0050794	regulation of cellular process	"Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]	OMA
NV2t025450001.1	biological_process	GO:0055088	lipid homeostasis	"Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl]	OMA
NV2t025450001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t025450001.1	cellular_component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	"A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730]	OMA
NV2t025450001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025450001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t025450001.1	molecular_function	GO:0038024	cargo receptor activity	"Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles." [PMID:15239958, PMID:27903609]	OMA
NV2t025451001.1	biological_process	GO:1904263	positive regulation of TORC1 signaling	"Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275]	PANTHER
NV2t025451001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	InterPro
NV2t025454001.1	molecular_function	GO:0004045	aminoacyl-tRNA hydrolase activity	"Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]	InterPro
NV2t025454001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t025454001.1	molecular_function	GO:0140101	catalytic activity, acting on a tRNA	"Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt]	OMA
NV2t025455001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025455001.1	molecular_function	GO:0051087	protein-folding chaperone binding	"Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443]	PANTHER
NV2t025457001.1	biological_process	GO:0051607	defense response to virus	"Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]	OMA
NV2t025457001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025458001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t025460001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t025460001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t025460001.1	molecular_function	GO:0003724	RNA helicase activity	"Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098]	OMA
NV2t025460001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025460001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025460002.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t025460002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025464001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t025466001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025467001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t025469001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t025470001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t025470001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t025470001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t025471001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t025471001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	OMA
NV2t025471001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t025472001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025472001.1	biological_process	GO:0071577	zinc ion transmembrane transport	"A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah]	PANTHER
NV2t025472001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025472001.1	molecular_function	GO:0046873	metal ion transmembrane transporter activity	"Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai]	OMA
NV2t025474001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025474001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	OMA
NV2t025474001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025474001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t025474001.1	molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	"Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]	OMA
NV2t025474001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025474002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025474002.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t025475001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025475001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025478001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025478001.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025478002.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478003.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478003.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478004.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478004.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478005.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478005.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478006.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478006.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478007.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025478007.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478007.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478008.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478008.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478009.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478009.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478010.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025478010.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478010.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025478010.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025478010.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025478011.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025478011.1	biological_process	GO:0030182	neuron differentiation	"The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]	PANTHER
NV2t025478011.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025481001.1	biological_process	GO:0010948	negative regulation of cell cycle process	"Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]	OMA
NV2t025481001.1	biological_process	GO:0043066	negative regulation of apoptotic process	"Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t025481001.1	biological_process	GO:0045931	positive regulation of mitotic cell cycle	"Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]	OMA
NV2t025481001.1	biological_process	GO:0051054	positive regulation of DNA metabolic process	"Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]	OMA
NV2t025481001.1	biological_process	GO:2000002	negative regulation of DNA damage checkpoint	"Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint." [GOC:BHF, GOC:obol]	OMA
NV2t025481001.1	biological_process	GO:2001252	positive regulation of chromosome organization	"Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol]	OMA
NV2t025481001.1	cellular_component	GO:0000781	chromosome, telomeric region	"The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh]	OMA
NV2t025481001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t025481001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	InterPro
NV2t025481001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025481001.1	cellular_component	GO:0008287	protein serine/threonine phosphatase complex	"A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]	OMA
NV2t025481001.1	cellular_component	GO:0016604	nuclear body	"Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]	OMA
NV2t025481001.1	cellular_component	GO:0072357	PTW/PP1 phosphatase complex	"A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061]	PANTHER
NV2t025481001.1	molecular_function	GO:0008157	protein phosphatase 1 binding	"Binding to a protein phosphatase 1." [GOC:jl]	OMA
NV2t025481001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025481001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t025482001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t025482001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	InterPro
NV2t025482001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t025482001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025482001.1	cellular_component	GO:0005840	ribosome	"An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]	OMA
NV2t025482001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t025483001.1	biological_process	GO:0009117	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	InterPro
NV2t025483001.1	biological_process	GO:0046085	adenosine metabolic process	"The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]	PANTHER
NV2t025483002.1	biological_process	GO:0009117	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	InterPro
NV2t025483002.1	biological_process	GO:0046085	adenosine metabolic process	"The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]	PANTHER
NV2t025484001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t025484001.1	molecular_function	GO:0030246	carbohydrate binding	"Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah]	OMA
NV2t025484001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025485001.1	biological_process	GO:0009117	nucleotide metabolic process	"The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]	InterPro
NV2t025485001.1	biological_process	GO:0046085	adenosine metabolic process	"The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]	PANTHER
NV2t025487001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	OMA
NV2t025487001.1	cellular_component	GO:0000151	ubiquitin ligase complex	"A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603]	PANTHER
NV2t025489001.1	biological_process	GO:0060271	cilium assembly	"The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2]	PANTHER
NV2t025490001.1	biological_process	GO:0006265	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	InterPro
NV2t025490001.1	biological_process	GO:0006265	DNA topological change	"The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]	OMA
NV2t025490001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025490001.1	cellular_component	GO:0044815	obsolete DNA packaging complex	"OBSOLETE. A protein complex that plays a role in the process of DNA packaging." [GOC:jl]	OMA
NV2t025490001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025490001.1	molecular_function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	InterPro
NV2t025490001.1	molecular_function	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	"Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]	OMA
NV2t025492001.1	molecular_function	GO:0004518	nuclease activity	"Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]	InterPro
NV2t025496001.1	biological_process	GO:0002221	pattern recognition receptor signaling pathway	"The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]	OMA
NV2t025496001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025496001.1	biological_process	GO:0043122	regulation of canonical NF-kappaB signal transduction	"Any process that modulates the canonical NF-kappaB signaling cascade." [GOC:jl, PMID:12773372]	OMA
NV2t025496001.1	biological_process	GO:1902533	positive regulation of intracellular signal transduction	"Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie]	OMA
NV2t025496001.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t025496001.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	OMA
NV2t025496002.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025496002.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t025496003.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025496003.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t025496004.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025496004.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t025496005.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025496005.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t025496006.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025496006.1	molecular_function	GO:0070976	TIR domain binding	"Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]	InterPro
NV2t025497001.1	biological_process	GO:0007165	signal transduction	"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]	InterPro
NV2t025498001.1	biological_process	GO:0006631	fatty acid metabolic process	"The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]	OMA
NV2t025498001.1	molecular_function	GO:0015645	fatty acid ligase activity	"Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [GOC:cjk, GOC:mah]	OMA
NV2t025498001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t025498001.1	molecular_function	GO:0031956	medium-chain fatty acid-CoA ligase activity	"Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:48340]	PANTHER
NV2t025498002.1	molecular_function	GO:0031956	medium-chain fatty acid-CoA ligase activity	"Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:48340]	PANTHER
NV2t025500001.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	InterPro
NV2t025500001.1	molecular_function	GO:0070273	phosphatidylinositol-4-phosphate binding	"Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah]	OMA
NV2t025501001.1	biological_process	GO:0006334	nucleosome assembly	"The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]	InterPro
NV2t025501001.1	molecular_function	GO:0042393	histone binding	"Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription." [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]	PANTHER
NV2t025502001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025504001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	InterPro
NV2t025504001.1	biological_process	GO:0051382	kinetochore assembly	"The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]	PANTHER
NV2t025504001.1	molecular_function	GO:0046982	protein heterodimerization activity	"Binding to a nonidentical protein to form a heterodimer." [GOC:ai]	InterPro
NV2t025505001.1	cellular_component	GO:0030130	clathrin coat of trans-Golgi network vesicle	"A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]	PANTHER
NV2t025505001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025506001.1	biological_process	GO:0051570	obsolete regulation of histone H3-K9 methylation	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]	PANTHER
NV2t025506001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025506001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t025506002.1	biological_process	GO:0051570	obsolete regulation of histone H3-K9 methylation	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]	PANTHER
NV2t025506002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025506002.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t025506003.1	biological_process	GO:0051570	obsolete regulation of histone H3-K9 methylation	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]	PANTHER
NV2t025506003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025506004.1	biological_process	GO:0051570	obsolete regulation of histone H3-K9 methylation	"OBSOLETE. Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]	PANTHER
NV2t025506004.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025506004.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t025507001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	OMA
NV2t025507001.1	biological_process	GO:0006637	acyl-CoA metabolic process	"The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732]	OMA
NV2t025507001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t025507001.1	molecular_function	GO:0015645	fatty acid ligase activity	"Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [GOC:cjk, GOC:mah]	OMA
NV2t025507001.1	molecular_function	GO:0015645	fatty acid ligase activity	"Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [GOC:cjk, GOC:mah]	PANTHER
NV2t025507001.1	molecular_function	GO:0016405	CoA-ligase activity	"Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]	OMA
NV2t025507001.1	molecular_function	GO:0016408	C-acyltransferase activity	"Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]	OMA
NV2t025508001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025508002.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025508003.1	biological_process	GO:0006575	cellular modified amino acid metabolic process	"The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t025508003.1	biological_process	GO:0034641	obsolete cellular nitrogen compound metabolic process	"OBSOLETE. The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah]	OMA
NV2t025508003.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025508003.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t025508003.1	molecular_function	GO:0016413	O-acetyltransferase activity	"Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	OMA
NV2t025508003.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025509001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025509001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t025509002.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025509003.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025510001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025510001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t025511001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025511001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025512001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025512001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	OMA
NV2t025514001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025523001.1	molecular_function	GO:0016279	protein-lysine N-methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]	OMA
NV2t025524001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025525001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025525002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025525003.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025525004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025525004.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025525004.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t025525005.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025525006.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025526001.1	cellular_component	GO:0062023	collagen-containing extracellular matrix	"An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617]	PANTHER
NV2t025527001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t025527001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025527001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t025528001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025528002.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025530001.1	biological_process	GO:0009062	fatty acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]	OMA
NV2t025530001.1	biological_process	GO:0019395	fatty acid oxidation	"The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t025530001.1	biological_process	GO:0034308	primary alcohol metabolic process	"The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah]	OMA
NV2t025530001.1	biological_process	GO:0046164	alcohol catabolic process	"The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai]	OMA
NV2t025530001.1	cellular_component	GO:0005777	peroxisome	"A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]	OMA
NV2t025530001.1	cellular_component	GO:0070013	intracellular organelle lumen	"An organelle lumen that is part of an intracellular organelle." [GOC:mah]	OMA
NV2t025530001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t025530001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025530001.1	molecular_function	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]	OMA
NV2t025530001.1	molecular_function	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]	OMA
NV2t025531001.1	molecular_function	GO:0010181	FMN binding	"Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]	OMA
NV2t025531001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	InterPro
NV2t025531001.1	molecular_function	GO:0016491	oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]	OMA
NV2t025533001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025533001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t025534001.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t025534001.1	molecular_function	GO:0016746	acyltransferase activity	"Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]	InterPro
NV2t025535002.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t025535002.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t025535003.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t025535003.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t025535004.1	biological_process	GO:0006633	fatty acid biosynthetic process	"The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732]	PANTHER
NV2t025535004.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	InterPro
NV2t025537001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	InterPro
NV2t025537001.1	biological_process	GO:0005975	carbohydrate metabolic process	"The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah, ISBN:0198506732]	OMA
NV2t025537001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	InterPro
NV2t025537001.1	molecular_function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	"Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]	OMA
NV2t025539001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	InterPro
NV2t025539001.1	molecular_function	GO:0008194	UDP-glycosyltransferase activity	"Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]	PANTHER
NV2t025539001.1	molecular_function	GO:0015020	glucuronosyltransferase activity	"Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032]	OMA
NV2t025540001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025541001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025541001.1	biological_process	GO:0007098	centrosome cycle	"The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]	OMA
NV2t025541001.1	cellular_component	GO:0000785	chromatin	"The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]	OMA
NV2t025541001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025541001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025541001.1	cellular_component	GO:0005813	centrosome	"A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]	OMA
NV2t025541001.1	cellular_component	GO:0032991	protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah]	OMA
NV2t025541001.1	molecular_function	GO:0003682	chromatin binding	"Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]	OMA
NV2t025541001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	InterPro
NV2t025541001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	OMA
NV2t025541001.1	molecular_function	GO:0003714	transcription corepressor activity	"A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]	PANTHER
NV2t025541001.1	molecular_function	GO:0048487	beta-tubulin binding	"Binding to the microtubule constituent protein beta-tubulin." [GOC:krc]	OMA
NV2t025542001.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t025542001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t025542001.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	OMA
NV2t025542002.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t025542003.1	molecular_function	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	"Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]	InterPro
NV2t025544001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t025544001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025544001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025545001.1	biological_process	GO:0006506	GPI anchor biosynthetic process	"The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]	OMA
NV2t025545001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025545001.1	biological_process	GO:0034394	protein localization to cell surface	"A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]	OMA
NV2t025545001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t025545001.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	OMA
NV2t025545001.1	molecular_function	GO:0004197	cysteine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t025545001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t025545002.1	cellular_component	GO:0042765	GPI-anchor transamidase complex	"An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]	InterPro
NV2t025545002.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	InterPro
NV2t025546001.1	biological_process	GO:0009142	nucleoside triphosphate biosynthetic process	"The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732]	OMA
NV2t025546001.1	biological_process	GO:0046034	ATP metabolic process	"The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]	OMA
NV2t025546001.1	biological_process	GO:0046705	CDP biosynthetic process	"The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai]	PANTHER
NV2t025546001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025546001.1	molecular_function	GO:0004017	adenylate kinase activity	"Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]	OMA
NV2t025546001.1	molecular_function	GO:0004550	nucleoside diphosphate kinase activity	"Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]	OMA
NV2t025546001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025546001.1	molecular_function	GO:0009041	UMP/dUMP kinase activity	"Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators]	InterPro
NV2t025546001.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t025546002.1	molecular_function	GO:0009041	UMP/dUMP kinase activity	"Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators]	InterPro
NV2t025546002.1	molecular_function	GO:0019205	nucleobase-containing compound kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]	InterPro
NV2t025557001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025557001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025557002.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025557002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025558001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t025559001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t025560001.1	molecular_function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	"Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide." [PMID:1899243]	PANTHER
NV2t025561001.1	biological_process	GO:0006412	translation	"The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]	InterPro
NV2t025561001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	OMA
NV2t025561001.1	biological_process	GO:0032543	mitochondrial translation	"The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]	PANTHER
NV2t025561001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t025561001.1	cellular_component	GO:0015935	small ribosomal subunit	"The smaller of the two subunits of a ribosome." [GOC:mah]	OMA
NV2t025561001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t025561001.1	molecular_function	GO:0003735	structural constituent of ribosome	"The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]	OMA
NV2t025562001.1	biological_process	GO:0007420	brain development	"The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]	OMA
NV2t025562001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	InterPro
NV2t025562001.1	biological_process	GO:0008299	isoprenoid biosynthetic process	"The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732]	OMA
NV2t025562001.1	biological_process	GO:1901663	quinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie]	OMA
NV2t025562001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t025562001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	PANTHER
NV2t025562001.1	molecular_function	GO:0004659	prenyltransferase activity	"Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]	OMA
NV2t025562001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t025563001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025564001.1	biological_process	GO:0045216	cell-cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	OMA
NV2t025564001.1	biological_process	GO:0045216	cell-cell junction organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	PANTHER
NV2t025565001.1	biological_process	GO:0098609	cell-cell adhesion	"The attachment of one cell to another cell via adhesion molecules." [GOC:dos]	PANTHER
NV2t025565001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025566001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025566002.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025566003.1	biological_process	GO:0035601	protein deacylation	"The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046]	OMA
NV2t025566003.1	biological_process	GO:0042159	lipoprotein catabolic process	"The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732]	OMA
NV2t025566003.1	biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	"Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]	OMA
NV2t025566003.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025566003.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t025566004.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025566005.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025566006.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025566007.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	InterPro
NV2t025567001.1	biological_process	GO:0044782	cilium organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]	PANTHER
NV2t025567001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025569001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025569001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025571001.1	biological_process	GO:0009790	embryo development	"The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]	PANTHER
NV2t025571001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t025573001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025574001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025574001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025574001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t025576001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025576001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025576001.1	molecular_function	GO:0004252	serine-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	OMA
NV2t025577001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025579001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025582001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025582001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025583001.1	biological_process	GO:0033209	tumor necrosis factor-mediated signaling pathway	"The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling]	OMA
NV2t025583001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	InterPro
NV2t025583001.1	biological_process	GO:0042981	regulation of apoptotic process	"Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]	OMA
NV2t025583001.1	biological_process	GO:0070534	protein K63-linked ubiquitination	"A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]	PANTHER
NV2t025583001.1	cellular_component	GO:0110165	cellular anatomical entity	"A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv]	OMA
NV2t025583001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025583001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025583001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025583001.1	molecular_function	GO:0032813	tumor necrosis factor receptor superfamily binding	"Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add]	OMA
NV2t025583001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025585001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025585001.1	biological_process	GO:0006626	protein targeting to mitochondrion	"The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]	OMA
NV2t025585001.1	biological_process	GO:0006627	protein processing involved in protein targeting to mitochondrion	"The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]	PANTHER
NV2t025585001.1	biological_process	GO:0034982	mitochondrial protein processing	"The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators]	OMA
NV2t025585001.1	cellular_component	GO:0005759	mitochondrial matrix	"The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]	OMA
NV2t025585001.1	cellular_component	GO:0098798	mitochondrial protein-containing complex	"A protein complex that is part of a mitochondrion." [GOC:dos]	OMA
NV2t025585001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t025585001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t025585001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t025585001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025585001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t025585002.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025585002.1	biological_process	GO:0006627	protein processing involved in protein targeting to mitochondrion	"The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]	PANTHER
NV2t025585002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025586001.1	biological_process	GO:0006658	phosphatidylserine metabolic process	"The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t025586001.1	biological_process	GO:0042219	cellular modified amino acid catabolic process	"The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]	OMA
NV2t025586001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t025586001.1	biological_process	GO:0046464	acylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]	OMA
NV2t025586001.1	biological_process	GO:0052651	monoacylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [PMID:25290914]	PANTHER
NV2t025586001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025586001.1	molecular_function	GO:0004620	phospholipase activity	"Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732]	OMA
NV2t025586001.1	molecular_function	GO:0008474	palmitoyl-(protein) hydrolase activity	"Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]	OMA
NV2t025586001.1	molecular_function	GO:0052689	carboxylic ester hydrolase activity	"Catalysis of the hydrolysis of a carboxylic ester bond." [GOC:curators]	OMA
NV2t025586003.1	biological_process	GO:0052651	monoacylglycerol catabolic process	"The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [PMID:25290914]	PANTHER
NV2t025587001.1	biological_process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	"Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators]	OMA
NV2t025587001.1	biological_process	GO:0045892	negative regulation of DNA-templated transcription	"Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025587001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025587001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025587001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025587001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025587001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025587001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025587001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t025587002.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025587002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025587002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025588001.1	biological_process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	"The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363]	OMA
NV2t025588001.1	biological_process	GO:0090158	endoplasmic reticulum membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	OMA
NV2t025588001.1	biological_process	GO:0090158	endoplasmic reticulum membrane organization	"A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]	PANTHER
NV2t025589001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025591001.1	biological_process	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling]	PANTHER
NV2t025592001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025592001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025593001.1	biological_process	GO:0006281	DNA repair	"The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]	InterPro
NV2t025593001.1	biological_process	GO:0019985	translesion synthesis	"The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901]	PANTHER
NV2t025595001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025596001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025596002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025596003.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025601001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025602001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025605001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	InterPro
NV2t025605001.1	biological_process	GO:0006457	protein folding	"The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]	OMA
NV2t025605001.1	biological_process	GO:0018208	peptidyl-proline modification	"The modification of peptidyl-proline." [GOC:go_curators]	OMA
NV2t025605001.1	cellular_component	GO:0071013	catalytic step 2 spliceosome	"A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]	PANTHER
NV2t025605001.1	cellular_component	GO:0140513	nuclear protein-containing complex	"A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg]	OMA
NV2t025605001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t025605001.1	cellular_component	GO:1990904	ribonucleoprotein complex	"A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles]	OMA
NV2t025605001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	InterPro
NV2t025605001.1	molecular_function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	"Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]	OMA
NV2t025607001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	OMA
NV2t025607001.1	molecular_function	GO:0003924	GTPase activity	"Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate." [PMID:26832457, PMID:27218782]	PANTHER
NV2t025607001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t025607001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	OMA
NV2t025611001.1	cellular_component	GO:0016459	myosin complex	"A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin]	OMA
NV2t025612001.1	biological_process	GO:0006478	peptidyl-tyrosine sulfation	"The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172]	OMA
NV2t025612001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	OMA
NV2t025612001.1	molecular_function	GO:0008476	protein-tyrosine sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]	InterPro
NV2t025612001.1	molecular_function	GO:0008476	protein-tyrosine sulfotransferase activity	"Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]	OMA
NV2t025614001.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	InterPro
NV2t025614001.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t025614002.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	InterPro
NV2t025614002.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	OMA
NV2t025614002.1	biological_process	GO:0006367	transcription initiation at RNA polymerase II promoter	"A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II." [GOC:mah, GOC:txnOH]	OMA
NV2t025614002.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	OMA
NV2t025614002.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t025614002.1	cellular_component	GO:0000439	transcription factor TFIIH core complex	"The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015]	OMA
NV2t025614002.1	cellular_component	GO:0005675	transcription factor TFIIH holo complex	"A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]	OMA
NV2t025614002.1	molecular_function	GO:0001671	ATPase activator activity	"Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp]	OMA
NV2t025614002.1	molecular_function	GO:0003690	double-stranded DNA binding	"Binding to double-stranded DNA." [GOC:elh, GOC:vw]	OMA
NV2t025614002.1	molecular_function	GO:0016251	RNA polymerase II general transcription initiation factor activity	"A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]	OMA
NV2t025614003.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	InterPro
NV2t025614003.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t025614004.1	biological_process	GO:0006289	nucleotide-excision repair	"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]	InterPro
NV2t025614004.1	biological_process	GO:0070816	obsolete phosphorylation of RNA polymerase II C-terminal domain	"OBSOLETE. The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]	PANTHER
NV2t025615001.1	cellular_component	GO:0043231	intracellular membrane-bounded organelle	"Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]	OMA
NV2t025615001.1	molecular_function	GO:0005319	lipid transporter activity	"Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai]	OMA
NV2t025615001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025615001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025615001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t025615001.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	OMA
NV2t025615002.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025615002.1	molecular_function	GO:0140359	ABC-type transporter activity	"Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899]	InterPro
NV2t025616001.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t025616001.1	biological_process	GO:0006438	valyl-tRNA aminoacylation	"The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t025616001.1	biological_process	GO:0006438	valyl-tRNA aminoacylation	"The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t025616002.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	InterPro
NV2t025616002.1	biological_process	GO:0006418	tRNA aminoacylation for protein translation	"The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]	OMA
NV2t025616002.1	biological_process	GO:0006438	valyl-tRNA aminoacylation	"The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	InterPro
NV2t025616002.1	biological_process	GO:0006438	valyl-tRNA aminoacylation	"The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510]	PANTHER
NV2t025616002.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025616002.1	molecular_function	GO:0002161	aminoacyl-tRNA editing activity	"The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]	OMA
NV2t025616002.1	molecular_function	GO:0004812	aminoacyl-tRNA ligase activity	"Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]	OMA
NV2t025616002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025617001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	InterPro
NV2t025617001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t025617001.1	molecular_function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]	OMA
NV2t025618001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t025618001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025618001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025618001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t025620001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	OMA
NV2t025620001.1	cellular_component	GO:0000139	Golgi membrane	"The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]	OMA
NV2t025620001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025620001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025620001.1	molecular_function	GO:0016829	lyase activity	"Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684]	OMA
NV2t025620001.1	molecular_function	GO:0016860	intramolecular oxidoreductase activity	"Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators]	OMA
NV2t025620001.1	molecular_function	GO:0050220	prostaglandin-E synthase activity	"Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12893]	InterPro
NV2t025620001.1	molecular_function	GO:0050220	prostaglandin-E synthase activity	"Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12893]	PANTHER
NV2t025620001.1	molecular_function	GO:0097159	organic cyclic compound binding	"Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672]	OMA
NV2t025620001.1	molecular_function	GO:1901363	heterocyclic compound binding	"Binding to heterocyclic compound." [GOC:TermGenie]	OMA
NV2t025621001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t025621001.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	InterPro
NV2t025621001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t025621002.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t025621002.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t025621002.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	InterPro
NV2t025621002.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t025621002.1	biological_process	GO:0048731	system development	"The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]	OMA
NV2t025621002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t025621002.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t025621002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025621002.1	molecular_function	GO:0004622	lysophospholipase activity	"Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine." [EC:3.1.1.5]	OMA
NV2t025621003.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t025621003.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	InterPro
NV2t025621003.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t025621004.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t025621004.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	InterPro
NV2t025621004.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t025621005.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	InterPro
NV2t025621005.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	InterPro
NV2t025621005.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	PANTHER
NV2t025623001.1	molecular_function	GO:0016846	carbon-sulfur lyase activity	"Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-]	InterPro
NV2t025626001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t025626001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t025627001.1	biological_process	GO:0048015	phosphatidylinositol-mediated signaling	"The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732]	OMA
NV2t025627001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025627001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025627001.1	molecular_function	GO:0004430	1-phosphatidylinositol 4-kinase activity	"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H+." [EC:2.7.1.67, RHEA:19877]	OMA
NV2t025627001.1	molecular_function	GO:0016301	kinase activity	"Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]	InterPro
NV2t025627001.1	molecular_function	GO:0052742	phosphatidylinositol kinase activity	"Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai]	PANTHER
NV2t025628001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025628002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025630001.1	biological_process	GO:0006511	ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators]	InterPro
NV2t025630001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	InterPro
NV2t025630001.1	biological_process	GO:0016579	protein deubiquitination	"The removal of one or more ubiquitin groups from a protein." [GOC:ai]	PANTHER
NV2t025631001.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	InterPro
NV2t025631001.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	OMA
NV2t025631001.1	biological_process	GO:0018344	protein geranylgeranylation	"The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl]	PANTHER
NV2t025631001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t025631001.1	molecular_function	GO:0004663	Rab geranylgeranyltransferase activity	"Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375]	OMA
NV2t025632001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	PANTHER
NV2t025632001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025632001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t025633001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	PANTHER
NV2t025634001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025637001.1	biological_process	GO:0006470	protein dephosphorylation	"The process of removing one or more phosphoric residues from a protein." [GOC:hb]	OMA
NV2t025637001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	OMA
NV2t025637001.1	molecular_function	GO:0004721	phosphoprotein phosphatase activity	"Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684]	OMA
NV2t025637001.1	molecular_function	GO:0016825	hydrolase activity, acting on acid phosphorus-nitrogen bonds	"Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl]	OMA
NV2t025637001.1	molecular_function	GO:0101006	protein histidine phosphatase activity	"Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate." [GOC:mec, RHEA:47964]	PANTHER
NV2t025638001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t025638001.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	PANTHER
NV2t025638002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	InterPro
NV2t025638002.1	molecular_function	GO:0005525	GTP binding	"Binding to GTP, guanosine triphosphate." [GOC:ai]	PANTHER
NV2t025639001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025640001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025640001.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t025640002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025640002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t025640002.1	biological_process	GO:0018105	peptidyl-serine phosphorylation	"The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]	PANTHER
NV2t025640002.1	molecular_function	GO:0004672	protein kinase activity	"Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640]	OMA
NV2t025640002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025640002.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025641001.1	biological_process	GO:0006396	RNA processing	"Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]	PANTHER
NV2t025643001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025643001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025643001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025643001.1	biological_process	GO:0045893	positive regulation of DNA-templated transcription	"Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025643001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025643001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t025645001.1	biological_process	GO:0006352	DNA-templated transcription initiation	"The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place." [GOC:jid, GOC:txnOH, PMID:18280161]	OMA
NV2t025645001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025645001.1	biological_process	GO:0006390	mitochondrial transcription	"The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl, PMID:23632312]	OMA
NV2t025645001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025645001.1	molecular_function	GO:0003712	transcription coregulator activity	"A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]	OMA
NV2t025645001.1	molecular_function	GO:0008170	N-methyltransferase activity	"Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]	OMA
NV2t025645001.1	molecular_function	GO:0008649	rRNA methyltransferase activity	"Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]	InterPro
NV2t025645001.1	molecular_function	GO:0016433	rRNA (adenine) methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators]	OMA
NV2t025645001.1	molecular_function	GO:0034246	mitochondrial transcription factor activity	"Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175]	PANTHER
NV2t025646001.1	biological_process	GO:0000045	autophagosome assembly	"The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464]	OMA
NV2t025646001.1	biological_process	GO:0000422	autophagy of mitochondrion	"The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344]	OMA
NV2t025646001.1	biological_process	GO:0006497	protein lipidation	"The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl]	OMA
NV2t025646001.1	biological_process	GO:0009267	cellular response to starvation	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]	OMA
NV2t025646001.1	biological_process	GO:0018410	C-terminal protein amino acid modification	"The alteration of the C-terminal amino acid residue in a protein." [GOC:mah]	OMA
NV2t025646001.1	biological_process	GO:0044804	nucleophagy	"A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549]	PANTHER
NV2t025646001.1	cellular_component	GO:0000407	phagophore assembly site	"Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]	OMA
NV2t025646001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025646001.1	cellular_component	GO:1990234	transferase complex	"A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]	OMA
NV2t025647001.1	biological_process	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	"The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]	InterPro
NV2t025647001.1	biological_process	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	"The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]	OMA
NV2t025647001.1	molecular_function	GO:0034038	deoxyhypusine synthase activity	"Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [GOC:pde, RHEA:33299]	PANTHER
NV2t025647002.1	biological_process	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	"The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]	InterPro
NV2t025647002.1	molecular_function	GO:0034038	deoxyhypusine synthase activity	"Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [GOC:pde, RHEA:33299]	PANTHER
NV2t025647003.1	biological_process	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine	"The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]	InterPro
NV2t025647003.1	molecular_function	GO:0034038	deoxyhypusine synthase activity	"Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [GOC:pde, RHEA:33299]	PANTHER
NV2t025648001.1	biological_process	GO:0006744	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	InterPro
NV2t025648002.1	biological_process	GO:0006744	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	InterPro
NV2t025648003.1	biological_process	GO:0006744	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	InterPro
NV2t025648004.1	biological_process	GO:0006744	ubiquinone biosynthetic process	"The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]	InterPro
NV2t025649001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t025649001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t025649001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025649001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t025649001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t025650001.1	biological_process	GO:0000398	mRNA splicing, via spliceosome	"The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]	OMA
NV2t025650001.1	biological_process	GO:0006397	mRNA processing	"Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]	InterPro
NV2t025650001.1	cellular_component	GO:0000932	P-body	"A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603]	OMA
NV2t025650001.1	cellular_component	GO:0097525	spliceosomal snRNP complex	"A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897]	OMA
NV2t025650001.1	cellular_component	GO:1902494	catalytic complex	"A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207]	OMA
NV2t025650001.1	cellular_component	GO:1990726	Lsm1-7-Pat1 complex	"A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]	PANTHER
NV2t025650001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025650001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t025652001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025652001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025653001.1	biological_process	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	InterPro
NV2t025653001.1	biological_process	GO:0007249	canonical NF-kappaB signal transduction	"An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." [GOC:bf, PMID:12773372, PMID:34659217]	OMA
NV2t025653001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025654001.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	PANTHER
NV2t025658001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025658001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025659001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t025659001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025659002.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t025659002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025659003.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t025659003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025659004.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t025659004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025659004.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025660001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025660002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025661001.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025661002.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t025661002.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025661003.1	biological_process	GO:0007219	Notch signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to the receptor Notch on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling]	PANTHER
NV2t025661003.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025662001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025662001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	PANTHER
NV2t025662001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	InterPro
NV2t025662001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t025664001.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t025664001.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t025664001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025664002.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t025664002.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t025664002.1	cellular_component	GO:0005886	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	OMA
NV2t025664002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025664002.1	cellular_component	GO:0043005	neuron projection	"A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]	OMA
NV2t025664002.1	cellular_component	GO:0045202	synapse	"The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]	OMA
NV2t025664002.1	molecular_function	GO:0004888	transmembrane signaling receptor activity	"Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]	OMA
NV2t025664002.1	molecular_function	GO:0005231	excitatory extracellular ligand-gated monoatomic ion channel activity	"Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070]	OMA
NV2t025664002.1	molecular_function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	"Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227]	OMA
NV2t025664003.1	biological_process	GO:0034220	monoatomic ion transmembrane transport	"A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom." [GOC:mah]	InterPro
NV2t025664003.1	biological_process	GO:0050877	nervous system process	"A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]	PANTHER
NV2t025664003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025665001.1	biological_process	GO:2000300	regulation of synaptic vesicle exocytosis	"Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]	PANTHER
NV2t025665002.1	biological_process	GO:2000300	regulation of synaptic vesicle exocytosis	"Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]	PANTHER
NV2t025666001.1	biological_process	GO:0006635	fatty acid beta-oxidation	"A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY]	OMA
NV2t025666001.1	biological_process	GO:0051791	medium-chain fatty acid metabolic process	"The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [Wikipedia:Fatty_acid_metabolisms]	OMA
NV2t025666001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025666001.1	molecular_function	GO:0003995	acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]." [RHEA:44704]	InterPro
NV2t025666001.1	molecular_function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	"Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	InterPro
NV2t025666001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	InterPro
NV2t025666001.1	molecular_function	GO:0050660	flavin adenine dinucleotide binding	"Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732]	OMA
NV2t025666001.1	molecular_function	GO:0070991	medium-chain fatty acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:14477]	OMA
NV2t025666001.1	molecular_function	GO:0070991	medium-chain fatty acyl-CoA dehydrogenase activity	"Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons." [RHEA:14477]	PANTHER
NV2t025668001.1	molecular_function	GO:0016787	hydrolase activity	"Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc." [ISBN:0198506732]	OMA
NV2t025668001.1	molecular_function	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	"Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]	InterPro
NV2t025669001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025669002.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025670003.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025670006.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025674001.1	cellular_component	GO:0072534	perineuronal net	"A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain." [GOC:sl, PMID:18364019]	PANTHER
NV2t025674001.1	molecular_function	GO:0005112	Notch binding	"Binding to a Notch (N) protein, a surface receptor." [GOC:ceb]	OMA
NV2t025674001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025674001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025675001.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t025675002.1	molecular_function	GO:0038023	signaling receptor activity	"Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]	PANTHER
NV2t025682001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	PANTHER
NV2t025683001.1	molecular_function	GO:0008233	peptidase activity	"Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]	PANTHER
NV2t025683001.1	molecular_function	GO:0070006	metalloaminopeptidase activity	"Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]	InterPro
NV2t025685001.1	biological_process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	"Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]	PANTHER
NV2t025685001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025686001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025686001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025688001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025689001.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025689002.1	molecular_function	GO:0070492	oligosaccharide binding	"Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]	PANTHER
NV2t025692001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	PANTHER
NV2t025698001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025700001.1	biological_process	GO:0010498	proteasomal protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]	OMA
NV2t025700001.1	biological_process	GO:0051603	proteolysis involved in protein catabolic process	"The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb]	InterPro
NV2t025700001.1	cellular_component	GO:0005839	proteasome core complex	"A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]	OMA
NV2t025700001.1	molecular_function	GO:0004298	threonine-type endopeptidase activity	"Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t025701001.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025701002.1	biological_process	GO:0019538	protein metabolic process	"The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma]	OMA
NV2t025701002.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t025701002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025701002.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	OMA
NV2t025701003.1	molecular_function	GO:0046872	metal ion binding	"Binding to a metal ion." [GOC:ai]	InterPro
NV2t025702001.1	molecular_function	GO:0016212	kynurenine-oxoglutarate transaminase activity	"Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7]	PANTHER
NV2t025702001.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t025702002.1	biological_process	GO:0009058	biosynthetic process	"The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]	OMA
NV2t025702002.1	biological_process	GO:0070189	kynurenine metabolic process	"The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph]	OMA
NV2t025702002.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025702002.1	molecular_function	GO:0008483	transaminase activity	"Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732]	OMA
NV2t025702002.1	molecular_function	GO:0016212	kynurenine-oxoglutarate transaminase activity	"Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7]	PANTHER
NV2t025702002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t025702002.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	OMA
NV2t025702003.1	molecular_function	GO:0016212	kynurenine-oxoglutarate transaminase activity	"Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7]	PANTHER
NV2t025702003.1	molecular_function	GO:0030170	pyridoxal phosphate binding	"Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]	InterPro
NV2t025704001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025704001.1	biological_process	GO:1902600	proton transmembrane transport	"The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie]	InterPro
NV2t025707001.1	molecular_function	GO:0051015	actin filament binding	"Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]	PANTHER
NV2t025709001.1	biological_process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	"The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]	PANTHER
NV2t025709001.1	cellular_component	GO:0005783	endoplasmic reticulum	"The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]	OMA
NV2t025709001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025709001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	OMA
NV2t025709001.1	molecular_function	GO:0031418	L-ascorbic acid binding	"Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah]	InterPro
NV2t025709001.1	molecular_function	GO:0031543	peptidyl-proline dioxygenase activity	"Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]	OMA
NV2t025712001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	InterPro
NV2t025712001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	InterPro
NV2t025712001.1	molecular_function	GO:0043138	3'-5' DNA helicase activity	"Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [EC:5.6.2.4, GOC:jl]	PANTHER
NV2t025713001.1	biological_process	GO:0007268	chemical synaptic transmission	"The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435]	OMA
NV2t025713001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025713001.1	molecular_function	GO:0004993	G protein-coupled serotonin receptor activity	"Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai]	OMA
NV2t025713001.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t025713002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025713002.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t025713003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025713003.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t025713004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025713004.1	molecular_function	GO:0030594	neurotransmitter receptor activity	"Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]	PANTHER
NV2t025714001.1	biological_process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	"A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194]	OMA
NV2t025714001.1	cellular_component	GO:0005887	plasma membrane	"The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]	PANTHER
NV2t025714001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025714001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025715001.1	biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	"The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]	PANTHER
NV2t025715001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025717001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	InterPro
NV2t025717001.1	biological_process	GO:0036211	protein modification process	"The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]	OMA
NV2t025717001.1	molecular_function	GO:0070740	tubulin-glutamic acid ligase activity	"Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]	PANTHER
NV2t025719001.1	biological_process	GO:0007166	cell surface receptor signaling pathway	"The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling]	OMA
NV2t025719001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025719001.1	molecular_function	GO:0004930	G protein-coupled receptor activity	"Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]	OMA
NV2t025721001.1	biological_process	GO:0046839	phospholipid dephosphorylation	"The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732]	OMA
NV2t025721001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025721001.1	molecular_function	GO:0042392	sphingosine-1-phosphate phosphatase activity	"Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:8663293]	PANTHER
NV2t025721001.1	molecular_function	GO:0042577	lipid phosphatase activity	"Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]	OMA
NV2t025722001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025722001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	InterPro
NV2t025723002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025723002.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025723003.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025726001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025726001.1	biological_process	GO:0016571	obsolete histone methylation	"OBSOLETE. The modification of histones by addition of methyl groups." [GOC:ai]	OMA
NV2t025726001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025726001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	InterPro
NV2t025726001.1	molecular_function	GO:0042054	histone methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue." [GOC:curators]	OMA
NV2t025732001.1	biological_process	GO:0008045	motor neuron axon guidance	"The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437]	OMA
NV2t025732001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t025732001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t025732001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t025732001.1	biological_process	GO:0016358	dendrite development	"The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]	OMA
NV2t025732001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t025734001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t025735001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	InterPro
NV2t025735001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t025735001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	PANTHER
NV2t025735001.1	cellular_component	GO:0005743	mitochondrial inner membrane	"The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]	OMA
NV2t025737001.1	biological_process	GO:0009887	animal organ morphogenesis	"Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544]	OMA
NV2t025737001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	OMA
NV2t025737001.1	biological_process	GO:0009888	tissue development	"The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]	PANTHER
NV2t025737001.1	biological_process	GO:0016043	cellular component organization	"A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]	OMA
NV2t025737001.1	biological_process	GO:0016477	cell migration	"The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]	OMA
NV2t025737001.1	biological_process	GO:0034446	substrate adhesion-dependent cell spreading	"The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732]	OMA
NV2t025737001.1	cellular_component	GO:0005604	basement membrane	"A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934]	OMA
NV2t025737001.1	molecular_function	GO:0005201	extracellular matrix structural constituent	"The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]	OMA
NV2t025738001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025738002.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025738003.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025738004.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025738005.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025738006.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025739001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t025739001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t025739001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t025739001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025739001.1	molecular_function	GO:0005096	GTPase activator activity	"Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]	OMA
NV2t025739001.1	molecular_function	GO:0051020	GTPase binding	"Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]	OMA
NV2t025740001.1	biological_process	GO:0010468	regulation of gene expression	"Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018]	PANTHER
NV2t025740001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025740001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025740001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t025742001.1	biological_process	GO:0006417	regulation of translation	"Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete]	PANTHER
NV2t025742001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025742001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025742001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t025744001.1	biological_process	GO:0006886	intracellular protein transport	"The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]	OMA
NV2t025744001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	InterPro
NV2t025744001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	OMA
NV2t025744001.1	cellular_component	GO:0017119	Golgi transport complex	"A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665]	PANTHER
NV2t025745001.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t025745001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025745002.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t025745002.1	cellular_component	GO:0000178	exosome (RNase complex)	"A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035]	OMA
NV2t025745002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025745002.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t025745003.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t025745003.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025745004.1	biological_process	GO:0071051	poly(A)-dependent snoRNA 3'-end processing	"Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092]	PANTHER
NV2t025745004.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	InterPro
NV2t025746001.1	biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	"Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025746001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	PANTHER
NV2t025746001.1	biological_process	GO:0031062	obsolete positive regulation of histone methylation	"OBSOLETE. Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]	OMA
NV2t025746001.1	biological_process	GO:0031175	neuron projection development	"The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]	OMA
NV2t025746001.1	biological_process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	"The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]	OMA
NV2t025746001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	OMA
NV2t025746001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025746001.1	molecular_function	GO:1990226	histone methyltransferase binding	"Binding to a histone methyltransferase enzyme." [GOC:ame, GOC:BHF, PMID:19486527]	OMA
NV2t025747001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t025747001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	OMA
NV2t025747001.1	cellular_component	GO:0140672	ATAC complex	"A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation." [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424]	PANTHER
NV2t025748001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025748001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	OMA
NV2t025748001.1	cellular_component	GO:0071598	neuronal ribonucleoprotein granule	"A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989]	PANTHER
NV2t025748001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025748001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t025748001.1	molecular_function	GO:0004674	protein serine/threonine kinase activity	"Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]	OMA
NV2t025748001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025748002.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025748002.1	cellular_component	GO:0071598	neuronal ribonucleoprotein granule	"A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989]	PANTHER
NV2t025748002.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025751001.1	cellular_component	GO:0005794	Golgi apparatus	"A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732]	PANTHER
NV2t025753001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025753001.1	molecular_function	GO:0022857	transmembrane transporter activity	"Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t025753002.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025753003.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025753004.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025760001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t025767001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025767001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025767001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025770001.1	biological_process	GO:0061343	cell adhesion involved in heart morphogenesis	"The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783]	PANTHER
NV2t025770001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t025770001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t025771002.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025771002.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025776001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t025835001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025835001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025835001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025857001.1	biological_process	GO:0008535	respiratory chain complex IV assembly	"The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]	OMA
NV2t025857001.1	biological_process	GO:0042775	mitochondrial ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]	OMA
NV2t025857001.1	cellular_component	GO:0005739	mitochondrion	"A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]	OMA
NV2t025857001.1	cellular_component	GO:0045277	respiratory chain complex IV	"A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]	OMA
NV2t025864001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025864001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t025864001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t025867001.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t025868001.1	molecular_function	GO:0071074	eukaryotic initiation factor eIF2 binding	"Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]	PANTHER
NV2t025869001.1	cellular_component	GO:0005634	nucleus	"A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]	PANTHER
NV2t025869001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025877001.1	biological_process	GO:0006611	protein export from nucleus	"The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]	OMA
NV2t025877001.1	biological_process	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	InterPro
NV2t025877001.1	cellular_component	GO:0005643	nuclear pore	"A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]	OMA
NV2t025877001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025877001.1	molecular_function	GO:0005049	nuclear export signal receptor activity	"Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]	OMA
NV2t025879001.1	biological_process	GO:0051169	nuclear transport	"The directed movement of substances into, out of, or within the nucleus." [GOC:ai]	InterPro
NV2t025880001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025880001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025880001.1	molecular_function	GO:0004180	carboxypeptidase activity	"Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]	OMA
NV2t025880001.1	molecular_function	GO:0070008	serine-type exopeptidase activity	"Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]	OMA
NV2t025882001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	InterPro
NV2t025884001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t025884001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025884001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025884001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t025898001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025899001.1	biological_process	GO:0006310	DNA recombination	"Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732]	OMA
NV2t025899001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025899001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025899001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025903001.1	molecular_function	GO:0003824	catalytic activity	"Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732]	OMA
NV2t025931001.1	biological_process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	"The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363]	OMA
NV2t025931001.1	biological_process	GO:0032981	mitochondrial respiratory chain complex I assembly	"The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]	OMA
NV2t025931001.1	biological_process	GO:0042773	ATP synthesis coupled electron transport	"The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]	InterPro
NV2t025931001.1	cellular_component	GO:0005747	mitochondrial respiratory chain complex I	"A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]	OMA
NV2t025931001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	OMA
NV2t025931001.1	molecular_function	GO:0009055	electron transfer activity	"A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways." [Wikipedia:Electron_transfer]	OMA
NV2t025931001.1	molecular_function	GO:0015453	oxidoreduction-driven active transmembrane transporter activity	"Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]	OMA
NV2t025931001.1	molecular_function	GO:0016651	oxidoreductase activity, acting on NAD(P)H	"Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]	OMA
NV2t025934001.1	biological_process	GO:0006259	DNA metabolic process	"Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]	OMA
NV2t025934001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025934001.1	biological_process	GO:0015074	DNA integration	"The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]	InterPro
NV2t025934001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025934001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t025934001.1	molecular_function	GO:0004190	aspartic-type endopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]	OMA
NV2t025935001.1	biological_process	GO:0006446	regulation of translational initiation	"Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]	OMA
NV2t025935001.1	molecular_function	GO:0003723	RNA binding	"Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah]	OMA
NV2t025935001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025935001.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	OMA
NV2t025935001.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	PANTHER
NV2t025935002.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025935002.1	molecular_function	GO:0008494	translation activator activity	"Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]	PANTHER
NV2t025937001.1	cellular_component	GO:0043186	P granule	"A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]	PANTHER
NV2t025937001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	InterPro
NV2t025937001.1	molecular_function	GO:0003676	nucleic acid binding	"Binding to a nucleic acid." [GOC:jl]	OMA
NV2t025937001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025939001.1	molecular_function	GO:0035091	phosphatidylinositol binding	"Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417]	InterPro
NV2t025940001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025940001.1	molecular_function	GO:0046974	histone H3K9 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein." [GOC:ai]	InterPro
NV2t025940001.1	molecular_function	GO:0046974	histone H3K9 methyltransferase activity	"Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein." [GOC:ai]	PANTHER
NV2t025942001.1	biological_process	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	"Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]	OMA
NV2t025942001.1	biological_process	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025942001.1	biological_process	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	OMA
NV2t025942001.1	molecular_function	GO:0008047	enzyme activator activity	"Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb]	OMA
NV2t025942002.1	biological_process	GO:0043085	positive regulation of catalytic activity	"Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t025943001.1	cellular_component	GO:0005829	cytosol	"The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl]	PANTHER
NV2t025946001.1	molecular_function	GO:0005509	calcium ion binding	"Binding to a calcium ion (Ca2+)." [GOC:ai]	InterPro
NV2t025959001.1	biological_process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	"Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]	PANTHER
NV2t025960001.1	biological_process	GO:0006629	lipid metabolic process	"The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]	PANTHER
NV2t025960001.1	biological_process	GO:0006658	phosphatidylserine metabolic process	"The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t025960001.1	biological_process	GO:0006672	ceramide metabolic process	"The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]	OMA
NV2t025960001.1	biological_process	GO:0046337	phosphatidylethanolamine metabolic process	"The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732]	OMA
NV2t025960001.1	biological_process	GO:0046339	diacylglycerol metabolic process	"The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11481335]	OMA
NV2t025960001.1	biological_process	GO:0046434	organophosphate catabolic process	"The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]	OMA
NV2t025960001.1	biological_process	GO:0046463	acylglycerol biosynthetic process	"The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]	OMA
NV2t025960001.1	biological_process	GO:0046470	phosphatidylcholine metabolic process	"The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t025960001.1	biological_process	GO:0046471	phosphatidylglycerol metabolic process	"The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732]	OMA
NV2t025960001.1	biological_process	GO:0046503	glycerolipid catabolic process	"The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]	OMA
NV2t025960001.1	biological_process	GO:1901565	organonitrogen compound catabolic process	"The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie]	OMA
NV2t025960001.1	cellular_component	GO:0005615	extracellular space	"That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]	OMA
NV2t025960001.1	cellular_component	GO:0005764	lysosome	"A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]	OMA
NV2t025960001.1	molecular_function	GO:0004623	phospholipase A2 activity	"Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801]	OMA
NV2t025960001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025960001.1	molecular_function	GO:0008374	O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]	InterPro
NV2t025960001.1	molecular_function	GO:0016411	acylglycerol O-acyltransferase activity	"Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]	OMA
NV2t025961001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	InterPro
NV2t025961001.1	biological_process	GO:0006508	proteolysis	"The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]	OMA
NV2t025961001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025961001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	OMA
NV2t025961001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	OMA
NV2t025961001.1	molecular_function	GO:0004222	metalloendopeptidase activity	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]	PANTHER
NV2t025961001.1	molecular_function	GO:0008237	metallopeptidase activity	"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]	InterPro
NV2t025961001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	InterPro
NV2t025961001.1	molecular_function	GO:0008270	zinc ion binding	"Binding to a zinc ion (Zn)." [GOC:ai]	OMA
NV2t025963001.1	biological_process	GO:0090630	activation of GTPase activity	"Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]	PANTHER
NV2t025975001.1	biological_process	GO:0051276	chromosome organization	"A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]	InterPro
NV2t025975001.1	molecular_function	GO:0061775	cohesin loader activity	"Facilitating a conformational change to load a cohesin complex around sister chromatids." [GOC:vw, PMID:26687354]	PANTHER
NV2t025976001.1	molecular_function	GO:0016887	ATP hydrolysis activity	"Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065]	InterPro
NV2t025976001.1	molecular_function	GO:0061775	cohesin loader activity	"Facilitating a conformational change to load a cohesin complex around sister chromatids." [GOC:vw, PMID:26687354]	PANTHER
NV2t025978001.1	cellular_component	GO:0005576	extracellular region	"The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]	OMA
NV2t025978001.1	molecular_function	GO:0030414	peptidase inhibitor activity	"Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]	OMA
NV2t025980001.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	PANTHER
NV2t025980002.1	biological_process	GO:0019915	lipid storage	"The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]	PANTHER
NV2t025984001.1	biological_process	GO:0007399	nervous system development	"The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]	OMA
NV2t025984001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025984001.1	cellular_component	GO:0005882	intermediate filament	"A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732]	OMA
NV2t025984001.1	molecular_function	GO:0005198	structural molecule activity	"The action of a molecule that contributes to the structural integrity of a complex." [GOC:mah, GOC:vw]	OMA
NV2t025985001.1	cellular_component	GO:0005635	nuclear envelope	"The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]	OMA
NV2t025985001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	OMA
NV2t025985001.1	cellular_component	GO:0005737	cytoplasm	"The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]	PANTHER
NV2t025986001.1	biological_process	GO:0071482	cellular response to light stimulus	"Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]	PANTHER
NV2t025986001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025988001.1	cellular_component	GO:0016020	membrane	"A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it." [GOC:dos, GOC:mah, ISBN:0815316194]	InterPro
NV2t025991001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t025991001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t025991001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t025991001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	OMA
NV2t025992001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t025993001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t025993001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	OMA
NV2t025993001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025993001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t025993001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t025993001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	OMA
NV2t025993001.1	molecular_function	GO:0005249	voltage-gated potassium channel activity	"Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]	OMA
NV2t025993001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025996001.1	biological_process	GO:0051260	protein homooligomerization	"The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]	InterPro
NV2t025996001.1	biological_process	GO:0055085	transmembrane transport	"The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid]	InterPro
NV2t025996001.1	biological_process	GO:0071805	potassium ion transmembrane transport	"A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah]	PANTHER
NV2t025996001.1	cellular_component	GO:0008076	voltage-gated potassium channel complex	"A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]	InterPro
NV2t025996001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025997001.1	biological_process	GO:0006468	protein phosphorylation	"The process of introducing a phosphate group on to a protein." [GOC:hb]	InterPro
NV2t025997001.1	cellular_component	GO:0043235	receptor complex	"Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]	PANTHER
NV2t025997001.1	molecular_function	GO:0004713	protein tyrosine kinase activity	"Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596]	OMA
NV2t025997001.1	molecular_function	GO:0005524	ATP binding	"Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]	OMA
NV2t025998001.1	biological_process	GO:0007548	sex differentiation	"The establishment of the sex of an organism by physical differentiation." [GOC:ai]	PANTHER
NV2t025998001.1	molecular_function	GO:0005515	protein binding	"Binding to a protein." [GOC:go_curators]	InterPro
NV2t025998001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t025999001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t025999001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t025999001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t025999001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025999001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t025999001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t030001001.1	biological_process	GO:0006355	regulation of DNA-templated transcription	"Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH]	InterPro
NV2t030001001.1	biological_process	GO:0048704	embryonic skeletal system morphogenesis	"The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113]	PANTHER
NV2t030001001.1	molecular_function	GO:0003677	DNA binding	"Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]	InterPro
NV2t030002001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t030002001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t030002001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t030002001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t030002001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t030002001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t030003001.1	biological_process	GO:0009653	anatomical structure morphogenesis	"The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]	OMA
NV2t030003001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	OMA
NV2t030003001.1	biological_process	GO:0030154	cell differentiation	"The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]	PANTHER
NV2t030003001.1	molecular_function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	"Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t030003001.1	molecular_function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	"A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018]	OMA
NV2t030003001.1	molecular_function	GO:0043565	sequence-specific DNA binding	"Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]	InterPro
NV2t030004001.1	biological_process	GO:0006357	regulation of transcription by RNA polymerase II	"Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH]	OMA
NV2t030004001.1	biological_process	GO:0032502	developmental process	"A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]	PANTHER
NV2t030004001.1	molecular_function	GO:0003700	DNA-binding transcription factor activity	"A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018]	OMA
NV2t030004001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	InterPro
NV2t030004001.1	molecular_function	GO:0046983	protein dimerization activity	"The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732]	OMA